Motif 1018 (n=249)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A087X0R7 | SENP3-EIF4A1 | T174 | ochoa | SENP3-EIF4A1 readthrough (NMD candidate) | None |
| A0A0C4DFX4 | None | T2197 | ochoa | Snf2 related CREBBP activator protein | None |
| A0A0C4DFX4 | None | T2547 | ochoa | Snf2 related CREBBP activator protein | None |
| A0A0C4DFX4 | None | T2707 | ochoa | Snf2 related CREBBP activator protein | None |
| A1L020 | MEX3A | T431 | ochoa | RNA-binding protein MEX3A (RING finger and KH domain-containing protein 4) | RNA binding protein, may be involved in post-transcriptional regulatory mechanisms. |
| A6NEL2 | SOWAHB | T267 | ochoa | Ankyrin repeat domain-containing protein SOWAHB (Ankyrin repeat domain-containing protein 56) (Protein sosondowah homolog B) | None |
| A8CG34 | POM121C | T973 | ochoa | Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| O00192 | ARVCF | T228 | ochoa | Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome) | Contributes to the regulation of alternative splicing of pre-mRNAs. {ECO:0000269|PubMed:24644279}. |
| O00267 | SUPT5H | T655 | ochoa | Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) | Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (PubMed:10075709, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed:10075709, PubMed:10199401, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed:16214896). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed:16214896). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (PubMed:16214896). Following phosphorylation by CDK9, DSIF can also positively regulate transcriptional elongation (PubMed:16427012). Required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat (PubMed:10393184, PubMed:10454543, PubMed:11809800, PubMed:9514752). DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences (PubMed:11112772, PubMed:14701750). {ECO:0000269|PubMed:10075709, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10421630, ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11553615, ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:12653964, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:14701750, ECO:0000269|PubMed:15136722, ECO:0000269|PubMed:15380072, ECO:0000269|PubMed:16214896, ECO:0000269|PubMed:16427012, ECO:0000269|PubMed:9450929, ECO:0000269|PubMed:9514752, ECO:0000269|PubMed:9857195}. |
| O00267 | SUPT5H | T658 | ochoa | Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) | Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (PubMed:10075709, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed:10075709, PubMed:10199401, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed:16214896). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed:16214896). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (PubMed:16214896). Following phosphorylation by CDK9, DSIF can also positively regulate transcriptional elongation (PubMed:16427012). Required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat (PubMed:10393184, PubMed:10454543, PubMed:11809800, PubMed:9514752). DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences (PubMed:11112772, PubMed:14701750). {ECO:0000269|PubMed:10075709, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10421630, ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11553615, ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:12653964, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:14701750, ECO:0000269|PubMed:15136722, ECO:0000269|PubMed:15380072, ECO:0000269|PubMed:16214896, ECO:0000269|PubMed:16427012, ECO:0000269|PubMed:9450929, ECO:0000269|PubMed:9514752, ECO:0000269|PubMed:9857195}. |
| O00512 | BCL9 | T1031 | ochoa | B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog) | Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11955446}. |
| O14497 | ARID1A | T294 | ochoa | AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (B120) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A) (Osa homolog 1) (hOSA1) (SWI-like protein) (SWI/SNF complex protein p270) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (hELD) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:A2BH40, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| O14686 | KMT2D | T1843 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14974 | PPP1R12A | T396 | ochoa | Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) | Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:20354225}. |
| O15013 | ARHGEF10 | T98 | ochoa | Rho guanine nucleotide exchange factor 10 | May play a role in developmental myelination of peripheral nerves. {ECO:0000269|PubMed:14508709}. |
| O15033 | AREL1 | T783 | psp | Apoptosis-resistant E3 ubiquitin protein ligase 1 (EC 2.3.2.26) (Apoptosis-resistant HECT-type E3 ubiquitin transferase 1) | E3 ubiquitin-protein ligase that catalyzes 'Lys-11'- or 'Lys-33'-linked polyubiquitin chains, with some preference for 'Lys-33' linkages (PubMed:25752577). E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:23479728, PubMed:31578312). Ubiquitinates SEPTIN4, DIABLO/SMAC and HTRA2 in vitro (PubMed:23479728). Modulates pulmonary inflammation by targeting SOCS2 for ubiquitination and subsequent degradation by the proteasome (PubMed:31578312). {ECO:0000269|PubMed:23479728, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:31578312}. |
| O15156 | ZBTB7B | T168 | ochoa | Zinc finger and BTB domain-containing protein 7B (Krueppel-related zinc finger protein cKrox) (hcKrox) (T-helper-inducing POZ/Krueppel-like factor) (Zinc finger and BTB domain-containing protein 15) (Zinc finger protein 67 homolog) (Zfp-67) (Zinc finger protein 857B) (Zinc finger protein Th-POK) | Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Cross-antagonism between ZBTB7B and CBF complexes are determinative to CD4 versus CD8 cell fate decision. Suppresses RUNX3 expression and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signaling. induces, as a transcriptional activator, SOCS genes expression which represses RUNX3 expression and promotes the CD4+ lineage fate. During CD4 lineage commitment, associates with multiple sites at the CD8 locus, acting as a negative regulator of the CD8 promoter and enhancers by epigenetic silencing through the recruitment of class II histone deacetylases, such as HDAC4 and HDAC5, to these loci. Regulates the development of IL17-producing CD1d-restricted naural killer (NK) T cells. Also functions as an important metabolic regulator in the lactating mammary glands. Critical feed-forward regulator of insulin signaling in mammary gland lactation, directly regulates expression of insulin receptor substrate-1 (IRS-1) and insulin-induced Akt-mTOR-SREBP signaling (By similarity). Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (PubMed:9370309). Potent driver of brown fat development, thermogenesis and cold-induced beige fat formation. Recruits the brown fat lncRNA 1 (Blnc1):HNRNPU ribonucleoprotein complex to activate thermogenic gene expression in brown and beige adipocytes (By similarity). {ECO:0000250|UniProtKB:Q64321, ECO:0000269|PubMed:9370309}. |
| O43150 | ASAP2 | T762 | ochoa | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 (Development and differentiation-enhancing factor 2) (Paxillin-associated protein with ARF GAP activity 3) (PAG3) (Pyk2 C-terminus-associated protein) (PAP) | Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration. {ECO:0000269|PubMed:10022920, ECO:0000269|PubMed:10749932, ECO:0000269|PubMed:11304556}. |
| O43474 | KLF4 | T315 | ochoa | Krueppel-like factor 4 (Epithelial zinc finger protein EZF) (Gut-enriched krueppel-like factor) | Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription. {ECO:0000269|PubMed:17308127, ECO:0000269|PubMed:20071344}. |
| O60336 | MAPKBP1 | T1357 | ochoa | Mitogen-activated protein kinase-binding protein 1 (JNK-binding protein 1) (JNKBP-1) | Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (PubMed:22700971). Involved in JNK signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6NS57, ECO:0000269|PubMed:22700971}. |
| O60341 | KDM1A | T88 | ochoa | Lysine-specific histone demethylase 1A (EC 1.14.99.66) (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2) ([histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A) | Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context (PubMed:15620353, PubMed:15811342, PubMed:16079794, PubMed:16079795, PubMed:16140033, PubMed:16223729, PubMed:27292636). Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed (PubMed:15620353, PubMed:15811342, PubMed:16079794, PubMed:21300290). Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me (PubMed:15620353, PubMed:20389281, PubMed:21300290, PubMed:23721412). May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity (PubMed:16079794, PubMed:16140033, PubMed:16885027, PubMed:21300290, PubMed:23721412). Also acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in AR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A (PubMed:16079795). Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1 (PubMed:29691401). Demethylates methylated 'Lys-42' and methylated 'Lys-117' of SOX2 (PubMed:29358331). Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (PubMed:16079794, PubMed:16140033). Facilitates epithelial-to-mesenchymal transition by acting as an effector of SNAI1-mediated transcription repression of epithelial markers E-cadherin/CDH1, CDN7 and KRT8 (PubMed:20562920, PubMed:27292636). Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7 (PubMed:20389281). Required for the repression of GIPR expression (PubMed:34655521, PubMed:34906447). {ECO:0000269|PubMed:12032298, ECO:0000269|PubMed:15620353, ECO:0000269|PubMed:15811342, ECO:0000269|PubMed:16079794, ECO:0000269|PubMed:16079795, ECO:0000269|PubMed:16140033, ECO:0000269|PubMed:16223729, ECO:0000269|PubMed:16885027, ECO:0000269|PubMed:16956976, ECO:0000269|PubMed:17805299, ECO:0000269|PubMed:20228790, ECO:0000269|PubMed:20389281, ECO:0000269|PubMed:20562920, ECO:0000269|PubMed:21300290, ECO:0000269|PubMed:23721412, ECO:0000269|PubMed:27292636, ECO:0000269|PubMed:29358331, ECO:0000269|PubMed:29691401, ECO:0000269|PubMed:34655521, ECO:0000269|PubMed:34906447}. |
| O60716 | CTNND1 | T201 | ochoa | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}. |
| O60927 | PPP1R11 | T102 | ochoa | E3 ubiquitin-protein ligase PPP1R11 (EC 2.3.2.27) (Hemochromatosis candidate gene V protein) (HCG V) (Protein phosphatase 1 regulatory subunit 11) (Protein phosphatase inhibitor 3) | Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2 (PubMed:27805901). Inhibitor of protein phosphatase 1 (PubMed:9843442). {ECO:0000269|PubMed:27805901, ECO:0000269|PubMed:9843442}. |
| O75112 | LDB3 | T513 | ochoa | LIM domain-binding protein 3 (Protein cypher) (Z-band alternatively spliced PDZ-motif protein) | May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton. {ECO:0000305}. |
| O75369 | FLNB | T1400 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75385 | ULK1 | T660 | ochoa | Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) | Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:37306101}. |
| O75385 | ULK1 | T755 | ochoa | Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) | Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:37306101}. |
| O75410 | TACC1 | T275 | ochoa | Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1) | Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269|PubMed:20078863}. |
| O95104 | SCAF4 | T236 | ochoa | SR-related and CTD-associated factor 4 (CTD-binding SR-like protein RA4) (Splicing factor, arginine/serine-rich 15) | Anti-terminator protein required to prevent early mRNA termination during transcription (PubMed:31104839). Together with SCAF8, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins (PubMed:31104839). Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation (PubMed:31104839). Independently of SCAF8, also acts as a suppressor of transcriptional readthrough (PubMed:31104839). {ECO:0000269|PubMed:31104839}. |
| O95295 | SNAPIN | T117 | psp | SNARE-associated protein Snapin (Biogenesis of lysosome-related organelles complex 1 subunit 7) (BLOC-1 subunit 7) (Synaptosomal-associated protein 25-binding protein) (SNAP-associated protein) | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells (PubMed:17182842, PubMed:18167355). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167). {ECO:0000269|PubMed:17182842, ECO:0000269|PubMed:18167355, ECO:0000269|PubMed:25898167}. |
| O95359 | TACC2 | T2238 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95613 | PCNT | T2154 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| O95817 | BAG3 | T217 | ochoa | BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) | Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8 (PubMed:27884606, PubMed:30559338). Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release (PubMed:27884606, PubMed:30559338). Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD) (PubMed:27474739, PubMed:9873016). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920). {ECO:0000269|PubMed:10597216, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:26159920, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27884606, ECO:0000269|PubMed:30559338, ECO:0000269|PubMed:9873016}. |
| O95865 | DDAH2 | T211 | psp | Putative hydrolase DDAH2 (EC 3.-.-.-) (DDAHII) (Inactive N(G),N(G)-dimethylarginine dimethylaminohydrolase 2) (DDAH-2) (Inactive dimethylarginine dimethylaminohydrolase 2) (Protein G6a) (S-phase protein) | Putative hydrolase with unknown substrate (Probable). Does not hydrolyze N(G),N(G)-dimethyl-L-arginine (ADMA) which acts as an inhibitor of NOS (PubMed:21493890, PubMed:37296100). In endothelial cells, induces expression of vascular endothelial growth factor (VEGF) via phosphorylation of the transcription factor SP1 by PKA in a process that is independent of NO and NO synthase (By similarity). Similarly, enhances pancreatic insulin secretion through SP1-mediated transcriptional up-regulation of secretagogin/SCGN, an insulin vesicle docking protein (By similarity). Upon viral infection, relocates to mitochondria where it promotes mitochondrial fission through activation of DNM1L leading to the inhibition of innate response activation mediated by MAVS (PubMed:33850055). {ECO:0000250|UniProtKB:Q99LD8, ECO:0000269|PubMed:21493890, ECO:0000269|PubMed:33850055, ECO:0000269|PubMed:37296100, ECO:0000305|PubMed:10493931, ECO:0000305|PubMed:21493890, ECO:0000305|PubMed:37296100}. |
| O96013 | PAK4 | T207 | ochoa | Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4) | Serine/threonine-protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell adhesion turnover, cell migration, growth, proliferation or cell survival (PubMed:26598620). Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN. Promotes kinase-independent stabilization of RHOU, thereby contributing to focal adhesion disassembly during cell migration (PubMed:26598620). {ECO:0000269|PubMed:11278822, ECO:0000269|PubMed:11313478, ECO:0000269|PubMed:14560027, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:20507994, ECO:0000269|PubMed:20631255, ECO:0000269|PubMed:20805321, ECO:0000269|PubMed:26598620, ECO:0000269|PubMed:26607847}. |
| P02452 | COL1A1 | T172 | ochoa | Collagen alpha-1(I) chain (Alpha-1 type I collagen) | Type I collagen is a member of group I collagen (fibrillar forming collagen). |
| P04049 | RAF1 | T49 | ochoa | RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) | Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}. |
| P04792 | HSPB1 | T180 | ochoa | Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Heat shock protein family B member 1) (Stress-responsive protein 27) (SRP27) | Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (PubMed:10383393, PubMed:20178975). Plays a role in stress resistance and actin organization (PubMed:19166925). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (PubMed:23728742). {ECO:0000269|PubMed:10383393, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:20178975, ECO:0000269|PubMed:23728742}. |
| P04818 | TYMS | T170 | psp | Thymidylate synthase (TS) (TSase) (EC 2.1.1.45) | Catalyzes the reductive methylation of 2'-deoxyuridine 5'-monophosphate (dUMP) to thymidine 5'-monophosphate (dTMP), using the cosubstrate, 5,10- methylenetetrahydrofolate (CH2H4folate) as a 1-carbon donor and reductant and contributes to the de novo mitochondrial thymidylate biosynthesis pathway. {ECO:0000269|PubMed:11278511, ECO:0000269|PubMed:21876188}. |
| P07203 | GPX1 | T145 | ochoa | Glutathione peroxidase 1 (GPx-1) (GSHPx-1) (EC 1.11.1.9) (Cellular glutathione peroxidase) (Phospholipid-hydroperoxide glutathione peroxidase GPX1) (EC 1.11.1.12) | Catalyzes the reduction of hydroperoxides in a glutathione-dependent manner thus regulating cellular redox homeostasis (PubMed:11115402, PubMed:36608588). Can reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide, as well as several fatty acid-derived hydroperoxides (PubMed:11115402, PubMed:36608588). In platelets catalyzes the reduction of 12-hydroperoxyeicosatetraenoic acid, the primary product of the arachidonate 12-lipoxygenase pathway (PubMed:11115402). {ECO:0000269|PubMed:11115402, ECO:0000269|PubMed:36608588}. |
| P08047 | SP1 | T723 | psp | Transcription factor Sp1 | Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Also binds the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component BMAL1 (PubMed:10391891, PubMed:11371615, PubMed:11904305, PubMed:14593115, PubMed:16377629, PubMed:16478997, PubMed:16943418, PubMed:17049555, PubMed:18171990, PubMed:18199680, PubMed:18239466, PubMed:18513490, PubMed:18619531, PubMed:19193796, PubMed:20091743, PubMed:21046154, PubMed:21798247). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity). {ECO:0000250|UniProtKB:O89090, ECO:0000250|UniProtKB:Q01714, ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11371615, ECO:0000269|PubMed:11904305, ECO:0000269|PubMed:14593115, ECO:0000269|PubMed:16377629, ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:16943418, ECO:0000269|PubMed:17049555, ECO:0000269|PubMed:18171990, ECO:0000269|PubMed:18199680, ECO:0000269|PubMed:18239466, ECO:0000269|PubMed:18513490, ECO:0000269|PubMed:18619531, ECO:0000269|PubMed:19193796, ECO:0000269|PubMed:20091743, ECO:0000269|PubMed:21046154, ECO:0000269|PubMed:21798247}. |
| P08588 | ADRB1 | T404 | psp | Beta-1 adrenergic receptor (Beta-1 adrenoreceptor) (Beta-1 adrenoceptor) | Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling. Involved in the regulation of sleep/wake behaviors (PubMed:31473062). {ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:31473062}. |
| P08865 | RPSA | T241 | ochoa | Small ribosomal subunit protein uS2 (37 kDa laminin receptor precursor) (37LRP) (37/67 kDa laminin receptor) (LRP/LR) (40S ribosomal protein SA) (67 kDa laminin receptor) (67LR) (Colon carcinoma laminin-binding protein) (Laminin receptor 1) (LamR) (Laminin-binding protein precursor p40) (LBP/p40) (Multidrug resistance-associated protein MGr1-Ag) (NEM/1CHD4) | Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. {ECO:0000255|HAMAP-Rule:MF_03016, ECO:0000269|PubMed:16263087, ECO:0000269|PubMed:6300843}.; FUNCTION: (Microbial infection) Acts as a receptor for the Adeno-associated viruses 2,3,8 and 9. {ECO:0000269|PubMed:16973587}.; FUNCTION: (Microbial infection) Acts as a receptor for the Dengue virus. {ECO:0000269|PubMed:15507651}.; FUNCTION: (Microbial infection) Acts as a receptor for the Sindbis virus. {ECO:0000269|PubMed:1385835}.; FUNCTION: (Microbial infection) Acts as a receptor for the Venezuelan equine encephalitis virus. {ECO:0000269|PubMed:1385835}.; FUNCTION: (Microbial infection) Acts as a receptor for the pathogenic prion protein. {ECO:0000269|PubMed:11689427, ECO:0000269|PubMed:9396609}.; FUNCTION: (Microbial infection) Acts as a receptor for bacteria. {ECO:0000269|PubMed:15516338}. |
| P10070 | GLI2 | T945 | ochoa | Zinc finger protein GLI2 (GLI family zinc finger protein 2) (Tax helper protein) | Functions as a transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992, PubMed:26565916). Functions as a transcriptional activator (PubMed:19878745, PubMed:24311597, PubMed:9557682). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856). {ECO:0000250|UniProtKB:Q0VGT2, ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:9557682, ECO:0000305|PubMed:20685856}.; FUNCTION: [Isoform 1]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 2]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 3]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 4]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 1]: Acts as a transcriptional activator in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 3]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 4]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 5]: Acts as a transcriptional repressor. {ECO:0000269|PubMed:15994174}. |
| P10415 | BCL2 | T74 | ochoa|psp | Apoptosis regulator Bcl-2 | Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells (PubMed:1508712, PubMed:8183370). Regulates cell death by controlling the mitochondrial membrane permeability (PubMed:11368354). Appears to function in a feedback loop system with caspases (PubMed:11368354). Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (PubMed:11368354). Also acts as an inhibitor of autophagy: interacts with BECN1 and AMBRA1 during non-starvation conditions and inhibits their autophagy function (PubMed:18570871, PubMed:20889974, PubMed:21358617). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785). {ECO:0000269|PubMed:1508712, ECO:0000269|PubMed:17418785, ECO:0000269|PubMed:18570871, ECO:0000269|PubMed:20889974, ECO:0000269|PubMed:21358617, ECO:0000269|PubMed:8183370, ECO:0000303|PubMed:11368354}. |
| P11474 | ESRRA | T31 | ochoa | Steroid hormone receptor ERR1 (Estrogen receptor-like 1) (Estrogen-related receptor alpha) (ERR-alpha) (Nuclear receptor subfamily 3 group B member 1) | Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle. {ECO:0000269|PubMed:12522104, ECO:0000269|PubMed:16150865, ECO:0000269|PubMed:17676930, ECO:0000269|PubMed:18063693, ECO:0000269|PubMed:23836911, ECO:0000269|PubMed:9271417}. |
| P18206 | VCL | T603 | ochoa | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
| P18887 | XRCC1 | T437 | ochoa | DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) | Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, PubMed:28002403). Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:28002403, PubMed:34102106, PubMed:34811483). Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483). {ECO:0000269|PubMed:11163244, ECO:0000269|PubMed:14500814, ECO:0000269|PubMed:28002403, ECO:0000269|PubMed:34102106, ECO:0000269|PubMed:34811483}. |
| P22681 | CBL | T615 | ochoa | E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL) | E3 ubiquitin-protein ligase that acts as a negative regulator of many signaling pathways by mediating ubiquitination of cell surface receptors (PubMed:10514377, PubMed:11896602, PubMed:14661060, PubMed:14739300, PubMed:15190072, PubMed:17509076, PubMed:18374639, PubMed:19689429, PubMed:21596750, PubMed:28381567). Accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome (PubMed:10514377, PubMed:14661060, PubMed:14739300, PubMed:17094949, PubMed:17509076, PubMed:17974561). Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, CSF1R, EPHA8 and KDR and mediates their ubiquitination to terminate signaling (PubMed:15190072, PubMed:18374639, PubMed:21596750). Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation (PubMed:11896602). Ubiquitinates EGFR and SPRY2 (PubMed:17094949, PubMed:17974561). Ubiquitinates NECTIN1 following association between NECTIN1 and herpes simplex virus 1/HHV-1 envelope glycoprotein D, leading to NECTIN1 removal from cell surface (PubMed:28381567). Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis (PubMed:15190072, PubMed:18374639). Essential for osteoclastic bone resorption (PubMed:14739300). The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14739300). May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:P22682, ECO:0000269|PubMed:10514377, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:14739300, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:17094949, ECO:0000269|PubMed:17509076, ECO:0000269|PubMed:17974561, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19689429, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:28381567}. |
| P22736 | NR4A1 | T55 | psp | Nuclear receptor subfamily 4immunitygroup A member 1 (Early response protein NAK1) (Nuclear hormone receptor NUR/77) (Nur77) (Orphan nuclear receptor HMR) (Orphan nuclear receptor TR3) (ST-59) (Testicular receptor 3) | Orphan nuclear receptor. Binds the NGFI-B response element (NBRE) 5'-AAAGGTCA-3' (PubMed:18690216, PubMed:8121493, PubMed:9315652). Binds 9-cis-retinoic acid outside of its ligand-binding (NR LBD) domain (PubMed:18690216). Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (PubMed:22983157). Regulates the inflammatory response in macrophages by regulating metabolic adaptations during inflammation, including repressing the transcription of genes involved in the citric acid cycle (TCA) (By similarity). Inhibits NF-kappa-B signaling by binding to low-affinity NF-kappa-B binding sites, such as at the IL2 promoter (PubMed:15466594). May act concomitantly with NR4A2 in regulating the expression of delayed-early genes during liver regeneration (By similarity). Plays a role in the vascular response to injury (By similarity). {ECO:0000250|UniProtKB:P12813, ECO:0000250|UniProtKB:P22829, ECO:0000269|PubMed:15466594, ECO:0000269|PubMed:18690216, ECO:0000269|PubMed:22983157, ECO:0000269|PubMed:8121493, ECO:0000269|PubMed:9315652}.; FUNCTION: In the cytosol, upon its detection of both bacterial lipopolysaccharide (LPS) and NBRE-containing mitochondrial DNA released by GSDMD pores during pyroptosis, it promotes non-canonical NLRP3 inflammasome activation by stimulating association of NLRP3 and NEK7. {ECO:0000250|UniProtKB:P12813}. |
| P23246 | SFPQ | T440 | ochoa | Splicing factor, proline- and glutamine-rich (100 kDa DNA-pairing protein) (hPOMp100) (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor) | DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. SFPQ may be involved in homologous DNA pairing; in vitro, promotes the invasion of ssDNA between a duplex DNA and produces a D-loop formation. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1; in vitro, stimulates dissociation of TOP1 from DNA after cleavage and enhances its jumping between separate DNA helices. The SFPQ-NONO heteromer binds DNA (PubMed:25765647). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends; in vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. SFPQ is involved in transcriptional regulation. Functions as a transcriptional activator (PubMed:25765647). Transcriptional repression is mediated by an interaction of SFPQ with SIN3A and subsequent recruitment of histone deacetylases (HDACs). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. SFPQ isoform Long binds to the DNA binding domains (DBD) of nuclear hormone receptors, like RXRA and probably THRA, and acts as a transcriptional corepressor in absence of hormone ligands. Binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF1-stimulated transcriptional activity. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation (By similarity). Required for the assembly of nuclear speckles (PubMed:25765647). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000250|UniProtKB:Q8VIJ6, ECO:0000269|PubMed:10847580, ECO:0000269|PubMed:10858305, ECO:0000269|PubMed:10931916, ECO:0000269|PubMed:11259580, ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:11897684, ECO:0000269|PubMed:15590677, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:25765647, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:8045264, ECO:0000269|PubMed:8449401}. |
| P23396 | RPS3 | T220 | ochoa | Small ribosomal subunit protein uS3 (40S ribosomal protein S3) (EC 4.2.99.18) | Component of the small ribosomal subunit (PubMed:23636399, PubMed:8706699). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571). Enhances the uracil excision activity of UNG1 (PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (PubMed:17049931). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (PubMed:18045535). Represses its own translation by binding to its cognate mRNA (PubMed:20217897). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (PubMed:23131551). Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (PubMed:22510408). {ECO:0000269|PubMed:14706345, ECO:0000269|PubMed:14988002, ECO:0000269|PubMed:15518571, ECO:0000269|PubMed:15707971, ECO:0000269|PubMed:17049931, ECO:0000269|PubMed:18045535, ECO:0000269|PubMed:18610840, ECO:0000269|PubMed:18973764, ECO:0000269|PubMed:19656744, ECO:0000269|PubMed:20217897, ECO:0000269|PubMed:20605787, ECO:0000269|PubMed:22510408, ECO:0000269|PubMed:23131551, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:23911537, ECO:0000269|PubMed:7775413, ECO:0000269|PubMed:8706699}. |
| P23588 | EIF4B | T450 | ochoa | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
| P27815 | PDE4A | T826 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) (cAMP-specific phosphodiesterase 4A) | Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:11566027, ECO:0000269|PubMed:2160582}.; FUNCTION: [Isoform 1]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 2]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 3]: Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP. {ECO:0000269|PubMed:7888306}.; FUNCTION: [Isoform 4]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:9677330}.; FUNCTION: [Isoform 6]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310, ECO:0000269|PubMed:17727341}.; FUNCTION: [Isoform 7]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:18095939}. |
| P27816 | MAP4 | T686 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P27987 | ITPKB | T354 | ochoa | Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase B) (IP3 3-kinase B) (IP3K B) (InsP 3-kinase B) | Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269|PubMed:11846419, ECO:0000269|PubMed:12747803, ECO:0000269|PubMed:1654894}. |
| P30622 | CLIP1 | T286 | ochoa | CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) | Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}. |
| P35269 | GTF2F1 | T427 | ochoa | General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74) | TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. {ECO:0000269|PubMed:10428810}. |
| P46821 | MAP1B | T1066 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P48552 | NRIP1 | T548 | ochoa | Nuclear receptor-interacting protein 1 (Nuclear factor RIP140) (Receptor-interacting protein 140) | Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function (By similarity). Plays a role in renal development (PubMed:28381549). {ECO:0000250|UniProtKB:Q8CBD1, ECO:0000269|PubMed:10364267, ECO:0000269|PubMed:11509661, ECO:0000269|PubMed:11518808, ECO:0000269|PubMed:12554755, ECO:0000269|PubMed:15060175, ECO:0000269|PubMed:21628546, ECO:0000269|PubMed:28381549, ECO:0000269|PubMed:7641693}. |
| P48634 | PRRC2A | T894 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P48634 | PRRC2A | T1131 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P49006 | MARCKSL1 | T174 | ochoa | MARCKS-related protein (MARCKS-like protein 1) (Macrophage myristoylated alanine-rich C kinase substrate) (Mac-MARCKS) (MacMARCKS) | Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation (PubMed:22751924). When unphosphorylated, induces cell migration (By similarity). When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration (By similarity). May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity). {ECO:0000250|UniProtKB:P28667, ECO:0000269|PubMed:22751924}. |
| P49593 | PPM1F | T25 | ochoa | Protein phosphatase 1F (EC 3.1.3.16) (Ca(2+)/calmodulin-dependent protein kinase phosphatase) (CaM-kinase phosphatase) (CaMKPase) (Partner of PIX 2) (Protein fem-2 homolog) (hFem-2) | Dephosphorylates and concomitantly deactivates CaM-kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis. |
| P49757 | NUMB | T561 | ochoa | Protein numb homolog (h-Numb) (Protein S171) | Regulates clathrin-mediated receptor endocytosis (PubMed:18657069). Plays a role in the process of neurogenesis (By similarity). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity). May also mediate local repair of brain ventricular wall damage (By similarity). {ECO:0000250|UniProtKB:Q9QZS3, ECO:0000269|PubMed:18657069}. |
| P52333 | JAK3 | T21 | ochoa | Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK) | Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A and STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion. {ECO:0000269|PubMed:11909529, ECO:0000269|PubMed:20440074, ECO:0000269|PubMed:7662955, ECO:0000269|PubMed:8022485}. |
| P52948 | NUP98 | T915 | ochoa | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}. |
| P53990 | IST1 | T218 | ochoa | IST1 homolog (hIST1) (Charged multivesicular body protein 8) (CHMP8) (Putative MAPK-activating protein PM28) | ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation (PubMed:19129479, PubMed:26040712, PubMed:28242692). Is required for efficient abscission during cytokinesis (PubMed:19129479). Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129479, PubMed:19129480). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712). Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2 (PubMed:28242692). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed:23897888). {ECO:0000269|PubMed:19129479, ECO:0000269|PubMed:19129480, ECO:0000269|PubMed:23897888, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:28242692}. |
| P57740 | NUP107 | T45 | ochoa | Nuclear pore complex protein Nup107 (107 kDa nucleoporin) (Nucleoporin Nup107) | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:12552102, PubMed:15229283, PubMed:30179222). Required for the assembly of peripheral proteins into the NPC (PubMed:12552102, PubMed:15229283). May anchor NUP62 to the NPC (PubMed:15229283). Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:12552102, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:30179222}. |
| P67809 | YBX1 | T25 | ochoa | Y-box-binding protein 1 (YB-1) (CCAAT-binding transcription factor I subunit A) (CBF-A) (DNA-binding protein B) (DBPB) (Enhancer factor I subunit A) (EFI-A) (Nuclease-sensitive element-binding protein 1) (Y-box transcription factor) | DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation (PubMed:10817758, PubMed:11698476, PubMed:14718551, PubMed:18809583, PubMed:31358969, PubMed:8188694). Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (PubMed:19561594, PubMed:31358969). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay (PubMed:10817758, PubMed:11698476, PubMed:31358969). Component of the CRD-mediated complex that promotes MYC mRNA stability (PubMed:19029303). Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs (PubMed:27559612, PubMed:29073095). Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (PubMed:28341602, PubMed:29073095). Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (PubMed:29712925). Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (PubMed:12604611). Binds to TSC22D1 transcripts, thereby inhibiting their translation and negatively regulating TGF-beta-mediated transcription of COL1A2 (By similarity). Also able to bind DNA: regulates transcription of the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7' (PubMed:18809583). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes (PubMed:18809583, PubMed:8188694). Promotes separation of DNA strands that contain mismatches or are modified by cisplatin (PubMed:14718551). Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair (PubMed:14718551). The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (PubMed:19483673). {ECO:0000250|UniProtKB:P62960, ECO:0000250|UniProtKB:Q28618, ECO:0000269|PubMed:10817758, ECO:0000269|PubMed:11698476, ECO:0000269|PubMed:12604611, ECO:0000269|PubMed:14718551, ECO:0000269|PubMed:18809583, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19483673, ECO:0000269|PubMed:19561594, ECO:0000269|PubMed:27559612, ECO:0000269|PubMed:28341602, ECO:0000269|PubMed:29073095, ECO:0000269|PubMed:29712925, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:8188694}. |
| P78559 | MAP1A | T1834 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P85037 | FOXK1 | T715 | ochoa | Forkhead box protein K1 (Myocyte nuclear factor) (MNF) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:17670796). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (By similarity). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (By similarity). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (By similarity). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (By similarity). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Represses myogenic differentiation by inhibiting MEFC activity (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK1-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:P42128, ECO:0000269|PubMed:17670796, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:25852164, ECO:0000269|PubMed:30664650}. |
| Q01082 | SPTBN1 | T2328 | ochoa | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q01844 | EWSR1 | T78 | ochoa | RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein) | Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Might normally function as a transcriptional repressor (PubMed:10767297). EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. {ECO:0000269|PubMed:10767297, ECO:0000269|PubMed:21256132}. |
| Q02078 | MEF2A | T215 | ochoa | Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1) | Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter. {ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:16371476, ECO:0000269|PubMed:16484498, ECO:0000269|PubMed:16563226, ECO:0000269|PubMed:21468593, ECO:0000269|PubMed:9858528}. |
| Q08211 | DHX9 | T98 | ochoa | ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (DExH-box helicase 9) (Leukophysin) (LKP) (Nuclear DNA helicase II) (NDH II) (RNA helicase A) | Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing (PubMed:11416126, PubMed:12711669, PubMed:15355351, PubMed:16680162, PubMed:17531811, PubMed:20669935, PubMed:21561811, PubMed:24049074, PubMed:24990949, PubMed:25062910, PubMed:28221134, PubMed:9111062, PubMed:37467750). Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs) (PubMed:1537828). Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA and RNA, DNA:RNA hybrids, DNA and RNA forks composed of either partially complementary DNA duplexes or DNA:RNA hybrids, respectively, and also DNA and RNA displacement loops (D- and R-loops), triplex-helical DNA (H-DNA) structure and DNA and RNA-based G-quadruplexes (PubMed:20669935, PubMed:21561811, PubMed:24049074). Binds dsDNA, single-stranded DNA (ssDNA), dsRNA, ssRNA and poly(A)-containing RNA (PubMed:10198287, PubMed:9111062). Also binds to circular dsDNA or dsRNA of either linear and/or circular forms and stimulates the relaxation of supercoiled DNAs catalyzed by topoisomerase TOP2A (PubMed:12711669). Plays a role in DNA replication at origins of replication and cell cycle progression (PubMed:24990949). Plays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors, such as BRCA1, CREBBP, RELA and SMN1 (PubMed:11038348, PubMed:11149922, PubMed:11416126, PubMed:15355351, PubMed:28221134, PubMed:9323138, PubMed:9662397). Binds to the CDKN2A promoter (PubMed:11038348). Plays several roles in post-transcriptional regulation of gene expression (PubMed:28221134, PubMed:28355180). In cooperation with NUP98, promotes pre-mRNA alternative splicing activities of a subset of genes (PubMed:11402034, PubMed:16680162, PubMed:28221134, PubMed:28355180). As component of a large PER complex, is involved in the negative regulation of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms (By similarity). Also acts as a nuclear resolvase that is able to bind and neutralize harmful massive secondary double-stranded RNA structures formed by inverted-repeat Alu retrotransposon elements that are inserted and transcribed as parts of genes during the process of gene transposition (PubMed:28355180). Involved in the positive regulation of nuclear export of constitutive transport element (CTE)-containing unspliced mRNA (PubMed:10924507, PubMed:11402034, PubMed:9162007). Component of the coding region determinant (CRD)-mediated complex that promotes cytoplasmic MYC mRNA stability (PubMed:19029303). Plays a role in mRNA translation (PubMed:28355180). Positively regulates translation of selected mRNAs through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Involved with LARP6 in the translation stimulation of type I collagen mRNAs for CO1A1 and CO1A2 through binding of a specific stem-loop structure in their 5'-UTRs (PubMed:22190748). Stimulates LIN28A-dependent mRNA translation probably by facilitating ribonucleoprotein remodeling during the process of translation (PubMed:21247876). Plays also a role as a small interfering (siRNA)-loading factor involved in the RNA-induced silencing complex (RISC) loading complex (RLC) assembly, and hence functions in the RISC-mediated gene silencing process (PubMed:17531811). Binds preferentially to short double-stranded RNA, such as those produced during rotavirus intestinal infection (PubMed:28636595). This interaction may mediate NLRP9 inflammasome activation and trigger inflammatory response, including IL18 release and pyroptosis (PubMed:28636595). Finally, mediates the attachment of heterogeneous nuclear ribonucleoproteins (hnRNPs) to actin filaments in the nucleus (PubMed:11687588). {ECO:0000250|UniProtKB:O70133, ECO:0000269|PubMed:10198287, ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:11038348, ECO:0000269|PubMed:11149922, ECO:0000269|PubMed:11402034, ECO:0000269|PubMed:11416126, ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:12711669, ECO:0000269|PubMed:15355351, ECO:0000269|PubMed:1537828, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:17531811, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:20669935, ECO:0000269|PubMed:21247876, ECO:0000269|PubMed:21561811, ECO:0000269|PubMed:22190748, ECO:0000269|PubMed:24049074, ECO:0000269|PubMed:24990949, ECO:0000269|PubMed:25062910, ECO:0000269|PubMed:28221134, ECO:0000269|PubMed:28355180, ECO:0000269|PubMed:28636595, ECO:0000269|PubMed:37467750, ECO:0000269|PubMed:9111062, ECO:0000269|PubMed:9162007, ECO:0000269|PubMed:9323138, ECO:0000269|PubMed:9662397}.; FUNCTION: (Microbial infection) Plays a role in HIV-1 replication and virion infectivity (PubMed:11096080, PubMed:19229320, PubMed:25149208, PubMed:27107641). Enhances HIV-1 transcription by facilitating the binding of RNA polymerase II holoenzyme to the proviral DNA (PubMed:11096080, PubMed:25149208). Binds (via DRBM domain 2) to the HIV-1 TAR RNA and stimulates HIV-1 transcription of transactivation response element (TAR)-containing mRNAs (PubMed:11096080, PubMed:9892698). Involved also in HIV-1 mRNA splicing and transport (PubMed:25149208). Positively regulates HIV-1 gag mRNA translation, through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Binds (via DRBM domains) to a HIV-1 double-stranded RNA region of the primer binding site (PBS)-segment of the 5'-UTR, and hence stimulates DHX9 incorporation into virions and virion infectivity (PubMed:27107641). Also plays a role as a cytosolic viral MyD88-dependent DNA and RNA sensors in plasmacytoid dendritic cells (pDCs), and hence induce antiviral innate immune responses (PubMed:20696886, PubMed:21957149). Binds (via the OB-fold region) to viral single-stranded DNA unmethylated C-phosphate-G (CpG) oligonucleotide (PubMed:20696886). {ECO:0000269|PubMed:11096080, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:20696886, ECO:0000269|PubMed:21957149, ECO:0000269|PubMed:25149208, ECO:0000269|PubMed:27107641, ECO:0000269|PubMed:9892698}. |
| Q08257 | CRYZ | T52 | ochoa | Quinone oxidoreductase (EC 1.6.5.5) (NADPH:quinone reductase) (Zeta-crystallin) | Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding. {ECO:0000269|PubMed:17497241, ECO:0000269|PubMed:20103721}. |
| Q12774 | ARHGEF5 | T971 | ochoa | Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) | Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}. |
| Q12888 | TP53BP1 | T1344 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12929 | EPS8 | T603 | ochoa | Epidermal growth factor receptor kinase substrate 8 | Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes. {ECO:0000269|PubMed:15558031, ECO:0000269|PubMed:17115031}. |
| Q13191 | CBLB | T885 | ochoa | E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B) | E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:Q3TTA7, ECO:0000269|PubMed:10022120, ECO:0000269|PubMed:10086340, ECO:0000269|PubMed:11087752, ECO:0000269|PubMed:11526404, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:20525694}. |
| Q13263 | TRIM28 | T620 | ochoa | Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}. |
| Q13428 | TCOF1 | T368 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13469 | NFATC2 | Y72 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}. |
| Q13487 | SNAPC2 | T292 | ochoa | snRNA-activating protein complex subunit 2 (SNAPc subunit 2) (Proximal sequence element-binding transcription factor subunit delta) (PSE-binding factor subunit delta) (PTF subunit delta) (Small nuclear RNA-activating complex polypeptide 2) (snRNA-activating protein complex 45 kDa subunit) (SNAPc 45 kDa subunit) | Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. |
| Q13492 | PICALM | T370 | ochoa | Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein) | Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly (PubMed:10436022, PubMed:16262731, PubMed:27574975). Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature (PubMed:25898166). In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8 (PubMed:21808019, PubMed:22118466, PubMed:23741335). In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors (PubMed:25241929). Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF) (PubMed:24067654, PubMed:25241929). {ECO:0000269|PubMed:10436022, ECO:0000269|PubMed:16262731, ECO:0000269|PubMed:21808019, ECO:0000269|PubMed:22118466, ECO:0000269|PubMed:23741335, ECO:0000269|PubMed:24067654, ECO:0000269|PubMed:25241929, ECO:0000269|PubMed:25898166, ECO:0000269|PubMed:27574975}. |
| Q13541 | EIF4EBP1 | T36 | ochoa | Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I) | Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. {ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:22684010, ECO:0000269|PubMed:7935836}. |
| Q13542 | EIF4EBP2 | T36 | ochoa | Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2) | Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (PubMed:30765518). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:25533957, PubMed:30765518). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity). {ECO:0000250|UniProtKB:P70445, ECO:0000269|PubMed:25533957, ECO:0000269|PubMed:30765518}. |
| Q13613 | MTMR1 | T36 | ochoa | Phosphatidylinositol-3-phosphate phosphatase MTMR1 (EC 3.1.3.-) (Myotubularin-related protein 1) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate, generating phosphatidylinositol (PubMed:11733541, PubMed:27018598). Could also dephosphorylate phosphatidylinositol 3,5-bisphosphate to produce phosphatidylinositol 5-phosphate (PubMed:27018598). {ECO:0000269|PubMed:11733541, ECO:0000269|PubMed:27018598}. |
| Q13625 | TP53BP2 | T355 | ochoa | Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2) | Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12694406, ECO:0000269|PubMed:19377511}. |
| Q14195 | DPYSL3 | T509 | psp | Dihydropyrimidinase-related protein 3 (DRP-3) (Collapsin response mediator protein 4) (CRMP-4) (Unc-33-like phosphoprotein 1) (ULIP-1) | Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity). {ECO:0000250}. |
| Q14676 | MDC1 | T659 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q15572 | TAF1C | T833 | ochoa | TATA box-binding protein-associated factor RNA polymerase I subunit C (RNA polymerase I-specific TBP-associated factor 110 kDa) (TAFI110) (TATA box-binding protein-associated factor 1C) (TBP-associated factor 1C) (Transcription initiation factor SL1/TIF-IB subunit C) | Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3. {ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:11283244, ECO:0000269|PubMed:15970593}. |
| Q15942 | ZYX | T250 | ochoa | Zyxin (Zyxin-2) | Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}. |
| Q16555 | DPYSL2 | T509 | ochoa|psp | Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (N2A3) (Unc-33-like phosphoprotein 2) (ULIP-2) | Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. {ECO:0000269|PubMed:11477421, ECO:0000269|PubMed:15466863, ECO:0000269|PubMed:20801876}. |
| Q27J81 | INF2 | T1179 | ochoa | Inverted formin-2 (HBEBP2-binding protein C) | Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}. |
| Q2M2I8 | AAK1 | T605 | ochoa | AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1) | Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis (PubMed:11877457, PubMed:11877461, PubMed:12952931, PubMed:14617351, PubMed:17494869, PubMed:25653444). Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1 (PubMed:17494869). Preferentially, may phosphorylate substrates on threonine residues (PubMed:11877457, PubMed:18657069). Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes (PubMed:12952931). Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes (PubMed:18657069). Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (PubMed:21464124). {ECO:0000269|PubMed:11877457, ECO:0000269|PubMed:11877461, ECO:0000269|PubMed:12952931, ECO:0000269|PubMed:14617351, ECO:0000269|PubMed:17494869, ECO:0000269|PubMed:18657069, ECO:0000269|PubMed:21464124, ECO:0000269|PubMed:25653444}.; FUNCTION: (Microbial infection) By regulating clathrin-mediated endocytosis, AAK1 plays a role in the entry of hepatitis C virus as well as for the lifecycle of other viruses such as Ebola and Dengue. {ECO:0000269|PubMed:25653444, ECO:0000305|PubMed:31136173}. |
| Q2M3G4 | SHROOM1 | T81 | ochoa | Protein Shroom1 (Apical protein 2) | May be involved in the assembly of microtubule arrays during cell elongation. {ECO:0000250}. |
| Q3KR37 | GRAMD1B | T286 | ochoa | Protein Aster-B (GRAM domain-containing protein 1B) | Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). {ECO:0000250|UniProtKB:Q80TI0}. |
| Q3YEC7 | RABL6 | T599 | ochoa | Rab-like protein 6 (GTP-binding protein Parf) (Partner of ARF) (Rab-like protein 1) (RBEL1) | May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A. {ECO:0000269|PubMed:16582619}. |
| Q5PRF9 | SAMD4B | T406 | ochoa|psp | Protein Smaug homolog 2 (Smaug 2) (hSmaug2) (Sterile alpha motif domain-containing protein 4B) (SAM domain-containing protein 4B) | Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A. {ECO:0000269|PubMed:20510020}. |
| Q5SV97 | PERM1 | T447 | ochoa | PGC-1 and ERR-induced regulator in muscle protein 1 (PPARGC1 and ESRR-induced regulator in muscle 1) (Peroxisome proliferator-activated receptor gamma coactivator 1 and estrogen-related receptor-induced regulator in muscle 1) | Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contractile function, muscle mitochondrial biogenesis and oxidative capacity. Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A. Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression of PDK4. {ECO:0000250|UniProtKB:Q149B8}. |
| Q5T0Z8 | C6orf132 | T297 | ochoa | Uncharacterized protein C6orf132 | None |
| Q5T5P2 | KIAA1217 | T345 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
| Q63ZY3 | KANK2 | T362 | ochoa | KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein) | Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q8BX02, ECO:0000269|PubMed:17476305, ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:22371500, ECO:0000269|PubMed:24671081, ECO:0000269|PubMed:25961457}. |
| Q641Q2 | WASHC2A | T1092 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q684P5 | RAP1GAP2 | T38 | ochoa | Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) | GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:15632203}. |
| Q68EM7 | ARHGAP17 | T793 | ochoa | Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) | Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}. |
| Q69YN4 | VIRMA | T62 | ochoa | Protein virilizer homolog | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:24981863, PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites (PubMed:29507755). Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon correlating with alternative polyadenylation (APA) (PubMed:29507755). {ECO:0000269|PubMed:24981863, ECO:0000269|PubMed:29507755}. |
| Q6IA86 | ELP2 | T128 | ochoa | Elongator complex protein 2 (ELP2) (SHINC-2) (STAT3-interacting protein 1) (StIP1) | Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29332244). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). {ECO:0000303|PubMed:29332244}. |
| Q6IQ23 | PLEKHA7 | T454 | ochoa | Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) | Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:30463011}. |
| Q6IQ23 | PLEKHA7 | T472 | ochoa | Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) | Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:30463011}. |
| Q6P1L5 | FAM117B | T123 | ochoa | Protein FAM117B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein) | None |
| Q6P3S6 | FBXO42 | T539 | ochoa | F-box only protein 42 (Just one F-box and Kelch domain-containing protein) | Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation. {ECO:0000269|PubMed:19509332}. |
| Q6P597 | KLC3 | T469 | ochoa | Kinesin light chain 3 (KLC2-like) (kinesin light chain 2) | Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Plays a role during spermiogenesis in the development of the sperm tail midpiece and in the normal function of spermatozoa (By similarity). May play a role in the formation of the mitochondrial sheath formation in the developing spermatid midpiece (By similarity). {ECO:0000250|UniProtKB:Q91W40}. |
| Q6PJG6 | BRAT1 | T751 | ochoa | Integrator complex assembly factor BRAT1 (BRCA1-associated ATM activator 1) (BRCA1-associated protein required for ATM activation protein 1) | Component of a multiprotein complex required for the assembly of the RNA endonuclease module of the integrator complex (PubMed:39032489, PubMed:39032490). Associates with INTS9 and INTS11 in the cytoplasm and blocks the active site of INTS11 to inhibit the endonuclease activity of INTS11 before formation of the full integrator complex (PubMed:39032489, PubMed:39032490). Following dissociation of WDR73 of the complex, BRAT1 facilitates the nuclear import of the INTS9-INTS11 heterodimer (PubMed:39032489). In the nucleus, INTS4 is integrated to the INTS9-INTS11 heterodimer and BRAT1 is released from the mature RNA endonuclease module by inositol hexakisphosphate (InsP6) (PubMed:39032489). BRAT1 is also involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress (PubMed:16452482, PubMed:22977523). Plays a role in regulating mitochondrial function and cell proliferation (PubMed:25070371). Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors (PubMed:25657994). {ECO:0000269|PubMed:16452482, ECO:0000269|PubMed:22977523, ECO:0000269|PubMed:25070371, ECO:0000269|PubMed:25657994, ECO:0000269|PubMed:39032489, ECO:0000269|PubMed:39032490}. |
| Q6SPF0 | SAMD1 | T416 | ochoa | Sterile alpha motif domain-containing protein 1 (SAM domain-containing protein 1) (Atherin) | Unmethylated CpG islands (CGIs)-binding protein which localizes to H3K4me3-decorated CGIs, where it acts as a transcriptional repressor (PubMed:33980486). Tethers L3MBTL3 to chromatin and interacts with the KDM1A histone demethylase complex to modulate H3K4me2 and H3K4me3 levels at CGIs (PubMed:33980486). Plays a role in atherogenesis by binding with LDL on cell surface and promoting LDL oxidation which leads to the formation of foam cell (PubMed:16159594, PubMed:34006929). {ECO:0000269|PubMed:16159594, ECO:0000269|PubMed:33980486, ECO:0000269|PubMed:34006929}. |
| Q6UWD8 | C16orf54 | T116 | ochoa | Transmembrane protein C16orf54 | None |
| Q6W2J9 | BCOR | T590 | ochoa | BCL-6 corepressor (BCoR) | Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:10898795, ECO:0000269|PubMed:15004558, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:19578371, ECO:0000269|PubMed:23911289}. |
| Q6ZRS2 | SRCAP | T2374 | ochoa | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
| Q6ZRS2 | SRCAP | T2724 | ochoa | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
| Q6ZRS2 | SRCAP | T2884 | ochoa | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
| Q765P7 | MTSS2 | T516 | ochoa | Protein MTSS 2 (Actin-bundling with BAIAP2 homology protein 1) (ABBA-1) (MTSS1-like protein) | Involved in plasma membrane dynamics. Potentiated PDGF-mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation (PubMed:14752106). May function in actin bundling (PubMed:14752106). {ECO:0000269|PubMed:14752106}. |
| Q7L311 | ARMCX2 | T225 | ochoa | Armadillo repeat-containing X-linked protein 2 (ARM protein lost in epithelial cancers on chromosome X 2) (Protein ALEX2) | May regulate the dynamics and distribution of mitochondria in neural cells. {ECO:0000250|UniProtKB:Q6A058}. |
| Q7Z2K8 | GPRIN1 | T873 | ochoa | G protein-regulated inducer of neurite outgrowth 1 (GRIN1) | May be involved in neurite outgrowth. {ECO:0000250}. |
| Q7Z2K8 | GPRIN1 | T973 | ochoa | G protein-regulated inducer of neurite outgrowth 1 (GRIN1) | May be involved in neurite outgrowth. {ECO:0000250}. |
| Q7Z3B3 | KANSL1 | T955 | ochoa | KAT8 regulatory NSL complex subunit 1 (MLL1/MLL complex subunit KANSL1) (MSL1 homolog 1) (hMSL1v1) (NSL complex protein NSL1) (Non-specific lethal 1 homolog) | Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:22547026, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria (PubMed:27768893). In addition to its role in transcription, KANSL1 also plays an essential role in spindle assembly during mitosis (PubMed:26243146). Associates with microtubule ends and contributes to microtubule stability (PubMed:26243146). {ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:26243146, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:33657400}. |
| Q7Z422 | SZRD1 | T67 | ochoa | SUZ RNA-binding domain-containing (SUZ domain-containing protein 1) (Putative MAPK-activating protein PM18/PM20/PM22) | None |
| Q86TJ2 | TADA2B | T133 | ochoa | Transcriptional adapter 2-beta (ADA2-like protein beta) (ADA2-beta) | Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2. {ECO:0000269|PubMed:12972612}. |
| Q86TJ2 | TADA2B | T136 | ochoa | Transcriptional adapter 2-beta (ADA2-like protein beta) (ADA2-beta) | Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2. {ECO:0000269|PubMed:12972612}. |
| Q86UU0 | BCL9L | T918 | ochoa | B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein) (BCL9-like protein) (Protein BCL9-2) | Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). {ECO:0000250}. |
| Q86WR7 | PROSER2 | T288 | ochoa | Proline and serine-rich protein 2 | None |
| Q86YW5 | TREML1 | T243 | ochoa | Trem-like transcript 1 protein (TLT-1) (Triggering receptor expressed on myeloid cells-like protein 1) | Cell surface receptor that may play a role in the innate and adaptive immune response. {ECO:0000269|PubMed:15128762}. |
| Q8IVH2 | FOXP4 | T276 | ochoa | Forkhead box protein P4 (Fork head-related protein-like A) | Transcriptional repressor that represses lung-specific expression. {ECO:0000250}. |
| Q8IVT2 | MISP | T223 | ochoa | Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) | Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}. |
| Q8IX07 | ZFPM1 | T139 | ochoa | Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1) | Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}. |
| Q8IXQ3 | C9orf40 | T94 | ochoa | Uncharacterized protein C9orf40 | None |
| Q8IXQ4 | GPALPP1 | T19 | ochoa | GPALPP motifs-containing protein 1 (Lipopolysaccharide-specific response protein 7) | None |
| Q8IZ69 | TRMT2A | T595 | ochoa | tRNA (uracil-5-)-methyltransferase homolog A (EC 2.1.1.35) (mRNA (uracil-5-)-methyltransferase TRMT2A) (EC 2.1.1.-) | S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine in tRNAs and some mRNAs (PubMed:31361898, PubMed:33799331, PubMed:34556860). Mainly catalyzes the methylation of uridine at position 54 (m5U54) in cytosolic tRNAs (PubMed:31361898, PubMed:33799331). Also able to mediate the formation of 5-methyl-uridine in some mRNAs (PubMed:34123281). {ECO:0000269|PubMed:31361898, ECO:0000269|PubMed:33799331, ECO:0000269|PubMed:34123281, ECO:0000269|PubMed:34556860}. |
| Q8IZL8 | PELP1 | T749 | ochoa | Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of non-genomic activity of estrogen receptor) (Transcription factor HMX3) | Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors (PubMed:14963108). Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. Regulates pre-60S association of the critical remodeling factor MDN1 (PubMed:21326211). May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. {ECO:0000269|PubMed:11481323, ECO:0000269|PubMed:12682072, ECO:0000269|PubMed:14963108, ECO:0000269|PubMed:15374949, ECO:0000269|PubMed:15456770, ECO:0000269|PubMed:15579769, ECO:0000269|PubMed:15994929, ECO:0000269|PubMed:16140940, ECO:0000269|PubMed:16352611, ECO:0000269|PubMed:16574651, ECO:0000269|PubMed:21326211, ECO:0000269|PubMed:22872859}. |
| Q8N0Y2 | ZNF444 | T228 | ochoa | Zinc finger protein 444 (Endothelial zinc finger protein 2) (EZF-2) (Zinc finger and SCAN domain-containing protein 17) | Transcriptional regulator. Binds to the 5'-flanking critical region of the SCARF1 promoter. |
| Q8N163 | CCAR2 | T454 | ochoa|psp | Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC) | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (PubMed:22446626). Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (PubMed:18235501, PubMed:18235502, PubMed:23352644). Inhibits SUV39H1 methyltransferase activity (PubMed:19218236). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress (PubMed:23398316). Regulates the circadian expression of the core clock components NR1D1 and BMAL1 (PubMed:23398316). Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978). {ECO:0000269|PubMed:18235501, ECO:0000269|PubMed:18235502, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19218236, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:22446626, ECO:0000269|PubMed:23352644, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25661920, ECO:0000269|PubMed:25732823}. |
| Q8N163 | CCAR2 | T461 | ochoa | Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC) | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (PubMed:22446626). Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (PubMed:18235501, PubMed:18235502, PubMed:23352644). Inhibits SUV39H1 methyltransferase activity (PubMed:19218236). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress (PubMed:23398316). Regulates the circadian expression of the core clock components NR1D1 and BMAL1 (PubMed:23398316). Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978). {ECO:0000269|PubMed:18235501, ECO:0000269|PubMed:18235502, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19218236, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:22446626, ECO:0000269|PubMed:23352644, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25661920, ECO:0000269|PubMed:25732823}. |
| Q8N163 | CCAR2 | T493 | ochoa | Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC) | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (PubMed:22446626). Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (PubMed:18235501, PubMed:18235502, PubMed:23352644). Inhibits SUV39H1 methyltransferase activity (PubMed:19218236). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress (PubMed:23398316). Regulates the circadian expression of the core clock components NR1D1 and BMAL1 (PubMed:23398316). Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978). {ECO:0000269|PubMed:18235501, ECO:0000269|PubMed:18235502, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19218236, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:22446626, ECO:0000269|PubMed:23352644, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25661920, ECO:0000269|PubMed:25732823}. |
| Q8N3J3 | HROB | T369 | ochoa | Homologous recombination OB-fold protein | DNA-binding protein involved in homologous recombination that acts by recruiting the MCM8-MCM9 helicase complex to sites of DNA damage to promote DNA repair synthesis. {ECO:0000269|PubMed:31467087}. |
| Q8N3V7 | SYNPO | T869 | ochoa | Synaptopodin | Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}. |
| Q8N4N8 | KIF2B | T125 | psp | Kinesin-like protein KIF2B | Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity (PubMed:17538014). Plays a role in chromosome congression (PubMed:23891108). {ECO:0000269|PubMed:17538014, ECO:0000269|PubMed:23891108}. |
| Q8N5S9 | CAMKK1 | T93 | ochoa | Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha) | Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. {ECO:0000269|PubMed:12935886}. |
| Q8N884 | CGAS | T130 | ochoa | Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (h-cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) | Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:21478870, PubMed:23258413, PubMed:23707061, PubMed:23707065, PubMed:23722159, PubMed:24077100, PubMed:24116191, PubMed:24462292, PubMed:25131990, PubMed:26300263, PubMed:29976794, PubMed:30799039, PubMed:31142647, PubMed:32814054, PubMed:33273464, PubMed:33542149, PubMed:37217469, PubMed:37802025). Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p] (PubMed:28214358, PubMed:28363908). Acts as a key DNA sensor: directly binds double-stranded DNA (dsDNA), inducing the formation of liquid-like droplets in which CGAS is activated, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates STING1, thereby triggering type-I interferon production (PubMed:28314590, PubMed:28363908, PubMed:29976794, PubMed:32817552, PubMed:33230297, PubMed:33606975, PubMed:35322803, PubMed:35438208, PubMed:35460603, PubMed:35503863). Preferentially recognizes and binds curved long dsDNAs of a minimal length of 40 bp (PubMed:30007416). Acts as a key foreign DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses (PubMed:28363908). Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm (PubMed:28363908, PubMed:35613581). Also acts as an innate immune sensor of infection by retroviruses, such as HIV-2, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:23929945, PubMed:24269171, PubMed:30270045, PubMed:32852081). In contrast, HIV-1 is poorly sensed by CGAS, due to its capsid that cloaks viral DNA from CGAS detection (PubMed:24269171, PubMed:30270045, PubMed:32852081). Detection of retroviral reverse-transcribed DNA in the cytosol may be indirect and be mediated via interaction with PQBP1, which directly binds reverse-transcribed retroviral DNA (PubMed:26046437). Also detects the presence of DNA from bacteria, such as M.tuberculosis (PubMed:26048138). 2',3'-cGAMP can be transferred from producing cells to neighboring cells through gap junctions, leading to promote STING1 activation and convey immune response to connecting cells (PubMed:24077100). 2',3'-cGAMP can also be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but STING1-dependent manner (PubMed:26229115). Also senses the presence of neutrophil extracellular traps (NETs) that are translocated to the cytosol following phagocytosis, leading to synthesis of 2',3'-cGAMP (PubMed:33688080). In addition to foreign DNA, can also be activated by endogenous nuclear or mitochondrial DNA (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297). When self-DNA leaks into the cytosol during cellular stress (such as mitochondrial stress, SARS-CoV-2 infection causing severe COVID-19 disease, DNA damage, mitotic arrest or senescence), or is present in form of cytosolic micronuclei, CGAS is activated leading to a state of sterile inflammation (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297, PubMed:35045565). Acts as a regulator of cellular senescence by binding to cytosolic chromatin fragments that are present in senescent cells, leading to trigger type-I interferon production via STING1 and promote cellular senescence (By similarity). Also involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability (PubMed:28738408, PubMed:28759889). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, CGAS binds self-DNA exposed to the cytosol, leading to 2',3'-cGAMP synthesis and subsequent activation of STING1 and type-I interferon production (PubMed:28738408, PubMed:28759889). Activated in response to prolonged mitotic arrest, promoting mitotic cell death (PubMed:31299200). In a healthy cell, CGAS is however kept inactive even in cellular events that directly expose it to self-DNA, such as mitosis, when cGAS associates with chromatin directly after nuclear envelope breakdown or remains in the form of postmitotic persistent nuclear cGAS pools bound to chromatin (PubMed:31299200, PubMed:33542149). Nuclear CGAS is inactivated by chromatin via direct interaction with nucleosomes, which block CGAS from DNA binding and thus prevent CGAS-induced autoimmunity (PubMed:31299200, PubMed:32911482, PubMed:32912999, PubMed:33051594, PubMed:33542149). Also acts as a suppressor of DNA repair in response to DNA damage: inhibits homologous recombination repair by interacting with PARP1, the CGAS-PARP1 interaction leading to impede the formation of the PARP1-TIMELESS complex (PubMed:30356214, PubMed:31544964). In addition to DNA, also sense translation stress: in response to translation stress, translocates to the cytosol and associates with collided ribosomes, promoting its activation and triggering type-I interferon production (PubMed:34111399). In contrast to other mammals, human CGAS displays species-specific mechanisms of DNA recognition and produces less 2',3'-cGAMP, allowing a more fine-tuned response to pathogens (PubMed:30007416). {ECO:0000250|UniProtKB:Q8C6L5, ECO:0000269|PubMed:21478870, ECO:0000269|PubMed:23258413, ECO:0000269|PubMed:23707061, ECO:0000269|PubMed:23707065, ECO:0000269|PubMed:23722159, ECO:0000269|PubMed:23929945, ECO:0000269|PubMed:24077100, ECO:0000269|PubMed:24116191, ECO:0000269|PubMed:24269171, ECO:0000269|PubMed:24462292, ECO:0000269|PubMed:25131990, ECO:0000269|PubMed:26046437, ECO:0000269|PubMed:26048138, ECO:0000269|PubMed:26229115, ECO:0000269|PubMed:26300263, ECO:0000269|PubMed:28214358, ECO:0000269|PubMed:28314590, ECO:0000269|PubMed:28363908, ECO:0000269|PubMed:28738408, ECO:0000269|PubMed:28759889, ECO:0000269|PubMed:29976794, ECO:0000269|PubMed:30007416, ECO:0000269|PubMed:30270045, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:30799039, ECO:0000269|PubMed:31142647, ECO:0000269|PubMed:31299200, ECO:0000269|PubMed:31544964, ECO:0000269|PubMed:32814054, ECO:0000269|PubMed:32817552, ECO:0000269|PubMed:32852081, ECO:0000269|PubMed:32911482, ECO:0000269|PubMed:32912999, ECO:0000269|PubMed:33031745, ECO:0000269|PubMed:33051594, ECO:0000269|PubMed:33230297, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33542149, ECO:0000269|PubMed:33606975, ECO:0000269|PubMed:33688080, ECO:0000269|PubMed:34111399, ECO:0000269|PubMed:35045565, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:35438208, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:35503863, ECO:0000269|PubMed:35613581, ECO:0000269|PubMed:37217469, ECO:0000269|PubMed:37802025}. |
| Q8N8Z6 | DCBLD1 | T614 | ochoa|psp | Discoidin, CUB and LCCL domain-containing protein 1 | None |
| Q8NE01 | CNNM3 | T682 | ochoa | Metal transporter CNNM3 (Ancient conserved domain-containing protein 3) (Cyclin-M3) | Probable metal transporter. {ECO:0000250}. |
| Q8TDY4 | ASAP3 | T735 | ochoa | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 (Development and differentiation-enhancing factor-like 1) (Protein up-regulated in liver cancer 1) | Promotes cell proliferation. {ECO:0000269|PubMed:14654939}. |
| Q8TER5 | ARHGEF40 | T249 | ochoa | Rho guanine nucleotide exchange factor 40 (Protein SOLO) | May act as a guanine nucleotide exchange factor (GEF). {ECO:0000250}. |
| Q8TF44 | C2CD4C | T73 | ochoa | C2 calcium-dependent domain-containing protein 4C (Nuclear-localized factor 3) (Protein FAM148C) | None |
| Q8WUF5 | PPP1R13L | T341 | ochoa | RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein) | Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900, ECO:0000269|PubMed:28069640}. |
| Q8WV28 | BLNK | T152 | psp | B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65) | Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis. {ECO:0000269|PubMed:10583958, ECO:0000269|PubMed:15270728, ECO:0000269|PubMed:16912232, ECO:0000269|PubMed:9697839}. |
| Q8WV99 | ZFAND2B | T160 | ochoa | AN1-type zinc finger protein 2B (Arsenite-inducible RNA-associated protein-like protein) (AIRAP-like protein) | Plays a role in protein homeostasis by regulating both the translocation and the ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic reticulum. It is involved in the regulation of signal-mediated translocation of proteins into the endoplasmic reticulum. It also plays a role in the ubiquitin-mediated proteasomal degradation of proteins for which signal-mediated translocation to the endoplasmic reticulum has failed. May therefore function in the endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:Q91X58, ECO:0000269|PubMed:26692333}. |
| Q8WXD9 | CASKIN1 | T783 | ochoa | Caskin-1 (CASK-interacting protein 1) | May link the scaffolding protein CASK to downstream intracellular effectors. {ECO:0000250}. |
| Q8WXG6 | MADD | T867 | ochoa | MAP kinase-activating death domain protein (Differentially expressed in normal and neoplastic cells) (Insulinoma glucagonoma clone 20) (Rab3 GDP/GTP exchange factor) (RabGEF) (Rab3 GDP/GTP exchange protein) (Rab3GEP) | Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion (By similarity). Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction (By similarity). Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses (By similarity). Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals (By similarity). Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2 (PubMed:32761064). May link TNFRSF1A with MAP kinase activation (PubMed:9115275). May be involved in the regulation of TNFA-induced apoptosis (PubMed:11577081, PubMed:32761064). {ECO:0000250|UniProtKB:O08873, ECO:0000250|UniProtKB:Q80U28, ECO:0000269|PubMed:11577081, ECO:0000269|PubMed:18559336, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:32761064, ECO:0000269|PubMed:9115275}. |
| Q92560 | BAP1 | T310 | ochoa | Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1) (Cerebral protein 6) | Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1 (PubMed:12485996, PubMed:18757409, PubMed:20436459, PubMed:25451922, PubMed:35051358). Catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1) (PubMed:20436459, PubMed:25451922, PubMed:30664650, PubMed:35051358). Does not deubiquitinate monoubiquitinated histone H2B (PubMed:20436459, PubMed:30664650). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:20805357, PubMed:30664650, PubMed:36180891). Antagonizes PRC1 mediated H2AK119ub1 monoubiquitination (PubMed:30664650). As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3 (PubMed:36180891). Recruited to specific gene-regulatory regions by YY1 (PubMed:20805357). Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains (PubMed:19188440, PubMed:19815555). Deubiquitination of HCFC1 does not lead to increase stability of HCFC1 (PubMed:19188440, PubMed:19815555). Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination (PubMed:19117993). It however does not mediate deubiquitination of BRCA1 and BARD1 (PubMed:19117993). Able to mediate autodeubiquitination via intramolecular interactions to counteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Negatively regulates epithelial-mesenchymal transition (EMT) of trophoblast stem cells during placental development by regulating genes involved in epithelial cell integrity, cell adhesion and cytoskeletal organization (PubMed:34170818). {ECO:0000269|PubMed:12485996, ECO:0000269|PubMed:18757409, ECO:0000269|PubMed:19117993, ECO:0000269|PubMed:19188440, ECO:0000269|PubMed:19815555, ECO:0000269|PubMed:20436459, ECO:0000269|PubMed:20805357, ECO:0000269|PubMed:24703950, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:34170818, ECO:0000269|PubMed:35051358, ECO:0000269|PubMed:36180891}. |
| Q92619 | ARHGAP45 | T86 | ochoa | Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)] | Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. {ECO:0000269|PubMed:24086303}.; FUNCTION: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. {ECO:0000269|PubMed:12601144, ECO:0000269|PubMed:8260714, ECO:0000269|PubMed:8532022, ECO:0000269|PubMed:9798702}. |
| Q92630 | DYRK2 | T106 | psp | Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1) | Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at 'Ser-457', promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro). {ECO:0000269|PubMed:11311121, ECO:0000269|PubMed:12588975, ECO:0000269|PubMed:14593110, ECO:0000269|PubMed:15910284, ECO:0000269|PubMed:16511445, ECO:0000269|PubMed:16611631, ECO:0000269|PubMed:17349958, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:18599021, ECO:0000269|PubMed:19287380, ECO:0000269|PubMed:22307329, ECO:0000269|PubMed:22878263, ECO:0000269|PubMed:23362280, ECO:0000269|PubMed:9748265}. |
| Q92841 | DDX17 | T55 | ochoa | Probable ATP-dependent RNA helicase DDX17 (EC 3.6.4.13) (DEAD box protein 17) (DEAD box protein p72) (DEAD box protein p82) (RNA-dependent helicase p72) | As an RNA helicase, unwinds RNA and alters RNA structures through ATP binding and hydrolysis. Involved in multiple cellular processes, including pre-mRNA splicing, alternative splicing, ribosomal RNA processing and miRNA processing, as well as transcription regulation. Regulates the alternative splicing of exons exhibiting specific features (PubMed:12138182, PubMed:22266867, PubMed:23022728, PubMed:24910439). For instance, promotes the inclusion of AC-rich alternative exons in CD44 transcripts (PubMed:12138182). This function requires the RNA helicase activity (PubMed:12138182, PubMed:22266867, PubMed:23022728, PubMed:24910439). Affects NFAT5 and histone macro-H2A.1/MACROH2A1 alternative splicing in a CDK9-dependent manner (PubMed:22266867, PubMed:26209609). In NFAT5, promotes the introduction of alternative exon 4, which contains 2 stop codons and may target NFAT5 exon 4-containing transcripts to nonsense-mediated mRNA decay, leading to the down-regulation of NFAT5 protein (PubMed:22266867). Affects splicing of mediators of steroid hormone signaling pathway, including kinases that phosphorylates ESR1, such as CDK2, MAPK1 and GSK3B, and transcriptional regulators, such as CREBBP, MED1, NCOR1 and NCOR2. By affecting GSK3B splicing, participates in ESR1 and AR stabilization (PubMed:24275493). In myoblasts and epithelial cells, cooperates with HNRNPH1 to control the splicing of specific subsets of exons (PubMed:24910439). In addition to binding mature mRNAs, also interacts with certain pri-microRNAs, including MIR663/miR-663a, MIR99B/miR-99b, and MIR6087/miR-6087 (PubMed:25126784). Binds pri-microRNAs on the 3' segment flanking the stem loop via the 5'-[ACG]CAUC[ACU]-3' consensus sequence (PubMed:24581491). Required for the production of subsets of microRNAs, including MIR21 and MIR125B1 (PubMed:24581491, PubMed:27478153). May be involved not only in microRNA primary transcript processing, but also stabilization (By similarity). Participates in MYC down-regulation at high cell density through the production of MYC-targeting microRNAs (PubMed:24581491). Along with DDX5, may be involved in the processing of the 32S intermediate into the mature 28S ribosomal RNA (PubMed:17485482). Promoter-specific transcription regulator, functioning as a coactivator or corepressor depending on the context of the promoter and the transcriptional complex in which it exists (PubMed:15298701). Enhances NFAT5 transcriptional activity (PubMed:22266867). Synergizes with TP53 in the activation of the MDM2 promoter; this activity requires acetylation on lysine residues (PubMed:17226766, PubMed:19995069, PubMed:20663877). May also coactivate MDM2 transcription through a TP53-independent pathway (PubMed:17226766). Coactivates MMP7 transcription (PubMed:17226766). Along with CTNNB1, coactivates MYC, JUN, FOSL1 and cyclin D1/CCND1 transcription (PubMed:17699760). Alone or in combination with DDX5 and/or SRA1 non-coding RNA, plays a critical role in promoting the assembly of proteins required for the formation of the transcription initiation complex and chromatin remodeling leading to coactivation of MYOD1-dependent transcription. This helicase-independent activity is required for skeletal muscle cells to properly differentiate into myotubes (PubMed:17011493, PubMed:24910439). During epithelial-to-mesenchymal transition, coregulates SMAD-dependent transcriptional activity, directly controlling key effectors of differentiation, including miRNAs which in turn directly repress its expression (PubMed:24910439). Plays a role in estrogen and testosterone signaling pathway at several levels. Mediates the use of alternative promoters in estrogen-responsive genes and regulates transcription and splicing of a large number of steroid hormone target genes (PubMed:19995069, PubMed:20406972, PubMed:20663877, PubMed:24275493). Contrary to splicing regulation activity, transcriptional coregulation of the estrogen receptor ESR1 is helicase-independent (PubMed:19718048, PubMed:24275493). Plays a role in innate immunity. Specifically restricts bunyavirus infection, including Rift Valley fever virus (RVFV) or La Crosse virus (LACV), but not vesicular stomatitis virus (VSV), in an interferon- and DROSHA-independent manner (PubMed:25126784). Binds to RVFV RNA, likely via structured viral RNA elements (PubMed:25126784). Promotes mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1, in an ATPase-dependent manner (PubMed:18334637). {ECO:0000250|UniProtKB:Q501J6, ECO:0000269|PubMed:12138182, ECO:0000269|PubMed:15298701, ECO:0000269|PubMed:17011493, ECO:0000269|PubMed:17226766, ECO:0000269|PubMed:17485482, ECO:0000269|PubMed:17699760, ECO:0000269|PubMed:18334637, ECO:0000269|PubMed:19718048, ECO:0000269|PubMed:19995069, ECO:0000269|PubMed:20406972, ECO:0000269|PubMed:20663877, ECO:0000269|PubMed:22266867, ECO:0000269|PubMed:23022728, ECO:0000269|PubMed:24275493, ECO:0000269|PubMed:24581491, ECO:0000269|PubMed:24910439, ECO:0000269|PubMed:25126784, ECO:0000269|PubMed:26209609, ECO:0000269|PubMed:27478153, ECO:0000305}. |
| Q92859 | NEO1 | T1226 | ochoa | Neogenin (Immunoglobulin superfamily DCC subclass member 2) | Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response. {ECO:0000269|PubMed:21149453}. |
| Q92917 | GPKOW | T26 | ochoa | G-patch domain and KOW motifs-containing protein (G-patch domain-containing protein 5) (Protein MOS2 homolog) (Protein T54) | RNA-binding protein involved in pre-mRNA splicing. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:25296192, ECO:0000305|PubMed:33509932}. |
| Q92997 | DVL3 | T346 | psp | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}. |
| Q93052 | LPP | T316 | ochoa | Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma) | May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. {ECO:0000269|PubMed:10637295}. |
| Q96D71 | REPS1 | T539 | ochoa | RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) | May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}. |
| Q96HC4 | PDLIM5 | T80 | ochoa | PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein) | May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation. {ECO:0000250|UniProtKB:Q62920}. |
| Q96JZ2 | HSH2D | T266 | ochoa | Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X) | May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity). Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter. {ECO:0000250, ECO:0000269|PubMed:11700021, ECO:0000269|PubMed:12960172, ECO:0000269|PubMed:15284240}. |
| Q96PC5 | MIA2 | T1191 | ochoa | Melanoma inhibitory activity protein 2 (MIA protein 2) (CTAGE family member 5 ER export factor) (Cutaneous T-cell lymphoma-associated antigen 5) (Meningioma-expressed antigen 6/11) | Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum (PubMed:21525241, PubMed:25202031, PubMed:27138255, PubMed:27170179). Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed:27138255). Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity). Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites (PubMed:21525241, PubMed:25202031, PubMed:27170179). {ECO:0000250|UniProtKB:Q91ZV0, ECO:0000269|PubMed:21525241, ECO:0000269|PubMed:25202031, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:27170179}. |
| Q96QC0 | PPP1R10 | T268 | ochoa | Serine/threonine-protein phosphatase 1 regulatory subunit 10 (MHC class I region proline-rich protein CAT53) (PP1-binding protein of 114 kDa) (Phosphatase 1 nuclear targeting subunit) (p99) | Substrate-recognition component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation (PubMed:39603239, PubMed:39603240). Promoter-proximal pausing by RNA polymerase II is a transcription halt following transcription initiation but prior to elongation, which acts as a checkpoint to control that transcripts are favorably configured for transcriptional elongation (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex mediates the release of RNA polymerase II from promoter-proximal region of genes by catalyzing dephosphorylation of proteins involved in transcription, such as AFF4, CDK9, MEPCE, INTS12, NCBP1, POLR2M/GDOWN1 and SUPT6H (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex also regulates RNA polymerase II transcription termination by mediating dephosphorylation of SUPT5H in termination zones downstream of poly(A) sites, thereby promoting deceleration of RNA polymerase II transcription (PubMed:31677974). PNUTS-PP1 complex is also involved in the response to replication stress by mediating dephosphorylation of POLR2A at 'Ser-5' of the CTD, promoting RNA polymerase II degradation (PubMed:33264625). The PNUTS-PP1 complex also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (By similarity). PNUTS-PP1 complex mediates dephosphorylation of MYC, promoting MYC stability by preventing MYC ubiquitination by the SCF(FBXW7) complex (PubMed:30158517). In addition to acts as a substrate-recognition component, PPP1R10/PNUTS also acts as a nuclear targeting subunit for the PNUTS-PP1 complex (PubMed:9450550). In some context, PPP1R10/PNUTS also acts as an inhibitor of protein phosphatase 1 (PP1) activity by preventing access to substrates, such as RB (PubMed:18360108). {ECO:0000250|UniProtKB:Q80W00, ECO:0000269|PubMed:18360108, ECO:0000269|PubMed:30158517, ECO:0000269|PubMed:31677974, ECO:0000269|PubMed:33264625, ECO:0000269|PubMed:39603239, ECO:0000269|PubMed:39603240, ECO:0000269|PubMed:9450550}. |
| Q96RT6 | CTAGE1 | T552 | ochoa | cTAGE family member 2 (Protein cTAGE-2) (Cancer/testis antigen 21.2) (CT21.2) | None |
| Q99459 | CDC5L | T429 | ochoa | Cell division cycle 5-like protein (Cdc5-like protein) (Pombe cdc5-related protein) | DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:11991638, PubMed:20176811, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30705154, PubMed:30728453). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR) (PubMed:20176811). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:10570151, ECO:0000269|PubMed:11082045, ECO:0000269|PubMed:11101529, ECO:0000269|PubMed:11544257, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:18583928, ECO:0000269|PubMed:20176811, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:9038199, ECO:0000269|PubMed:9468527, ECO:0000269|PubMed:9632794, ECO:0000305|PubMed:33509932}. |
| Q99569 | PKP4 | T265 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q99700 | ATXN2 | T717 | ochoa | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}. |
| Q99952 | PTPN18 | T409 | ochoa | Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase) | Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues. |
| Q9BQG0 | MYBBP1A | T946 | ochoa | Myb-binding protein 1A | May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309). {ECO:0000250|UniProtKB:Q7TPV4, ECO:0000269|PubMed:29065309}. |
| Q9BTK6 | PAGR1 | T25 | ochoa | PAXIP1-associated glutamate-rich protein 1 (Glutamate-rich coactivator interacting with SRC1) (GAS) (PAXIP1-associated protein 1) (PTIP-associated protein 1) | Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex (PubMed:19124460). However, its function in DNA damage has been questioned (By similarity). During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex (By similarity). Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition (PubMed:19039327). Acts as a transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent (PubMed:23161582). {ECO:0000250|UniProtKB:Q99L02, ECO:0000269|PubMed:19039327, ECO:0000269|PubMed:19124460, ECO:0000269|PubMed:23161582, ECO:0000305}. |
| Q9BVV6 | KIAA0586 | T1105 | ochoa | Protein TALPID3 | Required for ciliogenesis and sonic hedgehog/SHH signaling. Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. May play a role in early ciliogenesis in the disappearance of centriolar satellites that preceeds ciliary vesicle formation (PubMed:24421332). Involved in regulation of cell intracellular organization. Involved in regulation of cell polarity (By similarity). Required for asymmetrical localization of CEP120 to daughter centrioles (By similarity). {ECO:0000250|UniProtKB:E9PV87, ECO:0000250|UniProtKB:Q1G7G9, ECO:0000269|PubMed:24421332}. |
| Q9BW04 | SARG | T78 | ochoa | Specifically androgen-regulated gene protein | Putative androgen-specific receptor. {ECO:0000269|PubMed:15525603}. |
| Q9BXK1 | KLF16 | T225 | ochoa | Krueppel-like factor 16 (Basic transcription element-binding protein 4) (BTE-binding protein 4) (Novel Sp1-like zinc finger transcription factor 2) (Transcription factor BTEB4) (Transcription factor NSLP2) | Transcription factor that binds GC and GT boxes and displaces Sp1 and Sp3 from these sequences. Modulates dopaminergic transmission in the brain (By similarity). {ECO:0000250}. |
| Q9BY89 | KIAA1671 | T192 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9BY89 | KIAA1671 | T634 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9BZ72 | PITPNM2 | T807 | ochoa | Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (PITPnm 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3) | Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions. {ECO:0000269|PubMed:10022914}. |
| Q9C0C2 | TNKS1BP1 | T1430 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0D5 | TANC1 | T284 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
| Q9C0D5 | TANC1 | T347 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
| Q9H019 | MTFR1L | T44 | ochoa | Mitochondrial fission regulator 1-like | Mitochondrial protein required for adaptation of miochondrial dynamics to metabolic changes. Regulates mitochondrial morphology at steady state and mediates AMPK-dependent stress-induced mitochondrial fragmentation via the control of OPA1 levels. {ECO:0000269|PubMed:36367943}. |
| Q9H0E3 | SAP130 | T304 | ochoa | Histone deacetylase complex subunit SAP130 (130 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p130) | Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. {ECO:0000269|PubMed:12724404}. |
| Q9H4L4 | SENP3 | T244 | ochoa | Sentrin-specific protease 3 (EC 3.4.22.-) (SUMO-1-specific protease 3) (Sentrin/SUMO-specific protease SENP3) | Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates (PubMed:16608850, PubMed:32832608, PubMed:36050397). Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability (PubMed:15743823). Deconjugates SUMO2 and SUMO3 from CDCA8 (PubMed:18946085). Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300 (PubMed:19680224). Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1 (PubMed:19015314). Plays a role in the regulation of sumoylation status of ZNF148 (PubMed:18259216). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Deconjugates SUMO2 from KAT5 (PubMed:32832608). Catalyzes desumoylation of MRE11 (PubMed:36050397). {ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:18259216, ECO:0000269|PubMed:18946085, ECO:0000269|PubMed:19015314, ECO:0000269|PubMed:19680224, ECO:0000269|PubMed:22872859, ECO:0000269|PubMed:32832608, ECO:0000269|PubMed:36050397}. |
| Q9H4M7 | PLEKHA4 | T263 | ochoa | Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1) | Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides. {ECO:0000269|PubMed:11001876}. |
| Q9H792 | PEAK1 | T1106 | ochoa | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}. |
| Q9H7Z6 | KAT8 | T34 | ochoa | Histone acetyltransferase KAT8 (EC 2.3.1.48) (Lysine acetyltransferase 8) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1) (MYST-1) (Males-absent on the first protein homolog) (hMOF) (Protein acetyltransferase KAT8) (EC 2.3.1.-) (Protein propionyltransferase KAT8) (EC 2.3.1.-) | Histone acetyltransferase that catalyzes histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) or 'Lys-16' (H4K16ac), depending on the context (PubMed:12397079, PubMed:16227571, PubMed:16543150, PubMed:20018852, PubMed:21217699, PubMed:22020126, PubMed:22547026, PubMed:31794431, PubMed:33837287). Catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:12397079, PubMed:16227571, PubMed:16543150, PubMed:21217699, PubMed:22020126, PubMed:22547026, PubMed:33657400, PubMed:33837287). H4K16ac constitutes the only acetylation mark intergenerationally transmitted and regulates key biological processes, such as oogenesis, embryonic stem cell pluripotency, hematopoiesis or glucose metabolism (By similarity). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). As part of the NSL histone acetyltransferase complex, catalyzes histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:22547026, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria: KAT8 associates with mitochondrial DNA and controls expression of respiratory genes in an acetyltransferase-dependent mechanism (PubMed:27768893). Also functions as an acetyltransferase for non-histone targets, such as ALKBH5, COX17, IRF3, KDM1A/LSD1, LMNA, PAX7 or TP53/p53 (PubMed:17189187, PubMed:19854137, PubMed:37369679). Acts as an inhibitor of antiviral immunity by acetylating IRF3, preventing IRF3 recruitment to promoters (By similarity). Acts as a regulator of asymmetric division in muscle stem cells by mediating acetylation of PAX7 (By similarity). As part of the NSL complex, acetylates TP53/p53 at 'Lys-120' (PubMed:17189187, PubMed:19854137). Acts as a regulator of epithelial-to-mesenchymal transition as part of the NSL complex by mediating acetylation of KDM1A/LSD1 (PubMed:27292636). The NSL complex is required for nuclear architecture maintenance by mediating acetylation of LMNA (By similarity). Promotes mitochondrial integrity by catalyzing acetylation of COX17 (By similarity). In addition to protein acetyltransferase activity, able to mediate protein propionylation (PubMed:29321206). {ECO:0000250|UniProtKB:Q9D1P2, ECO:0000269|PubMed:12397079, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:17189187, ECO:0000269|PubMed:19854137, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:21217699, ECO:0000269|PubMed:22020126, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:27292636, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:29321206, ECO:0000269|PubMed:31794431, ECO:0000269|PubMed:33657400, ECO:0000269|PubMed:33837287, ECO:0000269|PubMed:37369679}. |
| Q9H8N7 | ZNF395 | T257 | ochoa | Zinc finger protein 395 (HD-regulating factor 2) (HDRF-2) (Huntington disease gene regulatory region-binding protein 2) (HD gene regulatory region-binding protein 2) (HDBP-2) (Papillomavirus regulatory factor 1) (PRF-1) (Papillomavirus-binding factor) | Plays a role in papillomavirus genes transcription. |
| Q9H987 | SYNPO2L | T705 | ochoa | Synaptopodin 2-like protein | Actin-associated protein that may play a role in modulating actin-based shape. {ECO:0000250}. |
| Q9HAP2 | MLXIP | T632 | ochoa | MLX-interacting protein (Class E basic helix-loop-helix protein 36) (bHLHe36) (Transcriptional activator MondoA) | Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. {ECO:0000250|UniProtKB:Q2VPU4, ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}. |
| Q9HAU0 | PLEKHA5 | T460 | ochoa | Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2) | None |
| Q9HBR0 | SLC38A10 | T639 | ochoa | Solute carrier family 38 member 10 (Amino acid transporter SLC38A10) | Facilitates bidirectional transport of amino acids. May act as a glutamate sensor that regulates glutamate-glutamine cycle and mTOR signaling in the brain. The transport mechanism remains to be elucidated. {ECO:0000250|UniProtKB:Q5I012}. |
| Q9NPF5 | DMAP1 | T424 | ochoa | DNA methyltransferase 1-associated protein 1 (DNMAP1) (DNMT1-associated protein 1) | Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity. {ECO:0000269|PubMed:14665632, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:14978102, ECO:0000269|PubMed:15367675}. |
| Q9NPG3 | UBN1 | T981 | ochoa | Ubinuclein-1 (HIRA-binding protein) (Protein VT4) (Ubiquitously expressed nuclear protein) | Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:19029251}. |
| Q9NQ75 | CASS4 | T157 | ochoa | Cas scaffolding protein family member 4 (HEF-like protein) (HEF1-EFS-p130Cas-like protein) (HEPL) | Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading. {ECO:0000269|PubMed:18256281}. |
| Q9NQ75 | CASS4 | T233 | ochoa | Cas scaffolding protein family member 4 (HEF-like protein) (HEF1-EFS-p130Cas-like protein) (HEPL) | Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading. {ECO:0000269|PubMed:18256281}. |
| Q9NQC3 | RTN4 | T188 | ochoa | Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) | Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). {ECO:0000269|PubMed:24262037, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26906412, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:27786289, ECO:0000305}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:10667797, ECO:0000269|PubMed:11201742, ECO:0000269|PubMed:19699797}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:11126360, ECO:0000269|PubMed:16965550, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:16965550}. |
| Q9NQS7 | INCENP | T135 | ochoa | Inner centromere protein | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}. |
| Q9NQV6 | PRDM10 | T823 | ochoa | PR domain zinc finger protein 10 (PR domain-containing protein 10) (Tristanin) | Transcriptional activator, essential for early embryonic development and survival of embryonic stem cells (ESCs) (By similarity). Supports cell growth and survival during early development by transcriptionally activating the expression of the translation initiation factor EIF3B, to sustain global translation (By similarity). Activates the transcription of FLNC (PubMed:36440963). {ECO:0000250|UniProtKB:Q3UTQ7, ECO:0000269|PubMed:36440963}. |
| Q9NX94 | WBP1L | T169 | ochoa | WW domain binding protein 1-like (Outcome predictor in acute leukemia 1) | None |
| Q9NZC9 | SMARCAL1 | T120 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.4.-) (HepA-related protein) (hHARP) (Sucrose nonfermenting protein 2-like 1) | ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks. {ECO:0000269|PubMed:18805831, ECO:0000269|PubMed:18974355, ECO:0000269|PubMed:19793861, ECO:0000269|PubMed:19793862}. |
| Q9P1Y6 | PHRF1 | T923 | ochoa | PHD and RING finger domain-containing protein 1 | None |
| Q9P212 | PLCE1 | T486 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (EC 3.1.4.11) (Pancreas-enriched phospholipase C) (Phosphoinositide phospholipase C-epsilon-1) (Phospholipase C-epsilon-1) (PLC-epsilon-1) | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downstream of AVIL to allow ARP2/3 complex assembly (PubMed:29058690). {ECO:0000269|PubMed:11022047, ECO:0000269|PubMed:11395506, ECO:0000269|PubMed:11715024, ECO:0000269|PubMed:11877431, ECO:0000269|PubMed:12721365, ECO:0000269|PubMed:16537651, ECO:0000269|PubMed:17086182, ECO:0000269|PubMed:29058690}. |
| Q9P219 | CCDC88C | T1910 | ochoa | Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2) | Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426). {ECO:0000269|PubMed:26126266, ECO:0000269|PubMed:30948426}. |
| Q9P227 | ARHGAP23 | T538 | ochoa | Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q9P2F8 | SIPA1L2 | T1521 | ochoa | Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) | None |
| Q9UBW5 | BIN2 | T366 | ochoa | Bridging integrator 2 (Breast cancer-associated protein 1) | Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}. |
| Q9UGP4 | LIMD1 | T69 | ochoa | LIM domain-containing protein 1 | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}. |
| Q9UKD1 | GMEB2 | T377 | ochoa | Glucocorticoid modulatory element-binding protein 2 (GMEB-2) (DNA-binding protein p79PIF) (Parvovirus initiation factor p79) (PIF p79) | Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Also binds to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses. |
| Q9UKS6 | PACSIN3 | T306 | ochoa | Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) | Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11082044}. |
| Q9ULM0 | PLEKHH1 | T311 | ochoa | Pleckstrin homology domain-containing family H member 1 (PH domain-containing family H member 1) | None |
| Q9ULV0 | MYO5B | T602 | ochoa | Unconventional myosin-Vb | May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis. Required for proper localization of bile salt export pump ABCB11 at the apical/canalicular plasma membrane of hepatocytes (PubMed:34816459). {ECO:0000269|PubMed:21206382, ECO:0000269|PubMed:21282656, ECO:0000269|PubMed:34816459}. |
| Q9UMN6 | KMT2B | T2068 | ochoa | Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q9UMY4 | SNX12 | T20 | ochoa | Sorting nexin-12 | May be involved in several stages of intracellular trafficking. {ECO:0000250}. |
| Q9UPN4 | CEP131 | T137 | ochoa | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) | Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}. |
| Q9UPQ9 | TNRC6B | T1449 | ochoa | Trinucleotide repeat-containing gene 6B protein | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (PubMed:21981923). {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:32354837}. |
| Q9UPR0 | PLCL2 | T91 | ochoa | Inactive phospholipase C-like protein 2 (PLC-L(2)) (PLC-L2) (Phospholipase C-L2) (Phospholipase C-epsilon-2) (PLC-epsilon-2) | May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum. {ECO:0000250}. |
| Q9UQB8 | BAIAP2 | T253 | ochoa | BAR/IMD domain-containing adapter protein 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2) (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) | Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. {ECO:0000269|PubMed:11130076, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:14752106, ECO:0000269|PubMed:17115031, ECO:0000269|PubMed:19366662}. |
| Q9UQQ2 | SH2B3 | T159 | ochoa | SH2B adapter protein 3 (Lymphocyte adapter protein) (Lymphocyte-specific adapter protein Lnk) (Signal transduction protein Lnk) | Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase. {ECO:0000250}. |
| Q9Y2K6 | USP20 | T352 | ochoa | Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (VHL-interacting deubiquitinating enzyme 2) (hVDU2) | Deubiquitinating enzyme that plays a role in many cellular processes including autophagy, cellular antiviral response or membrane protein biogenesis (PubMed:27801882, PubMed:29487085). Attenuates TLR4-mediated NF-kappa-B signaling by cooperating with beta-arrestin-2/ARRB2 and inhibiting TRAF6 autoubiquitination (PubMed:26839314). Promotes cellular antiviral responses by deconjugating 'Lys-33' and 'Lys-48'-linked ubiquitination of STING1 leading to its stabilization (PubMed:27801882). Plays an essential role in autophagy induction by regulating the ULK1 stability through deubiquitination of ULK1 (PubMed:29487085). Acts as a positive regulator for NF-kappa-B activation by TNF-alpha through deubiquitinating 'Lys-48'-linked polyubiquitination of SQSTM1, leading to its increased stability (PubMed:32354117). Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2) (PubMed:19424180). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2 (PubMed:19424180). This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity (PubMed:15776016). Deubiquitinates MCL1, a pivotal member of the anti-apoptotic Bcl-2 protein family to regulate its stability (PubMed:35063767). Within the endoplasmic reticulum, participates with USP33 in the rescue of post-translationally targeted membrane proteins that are inappropriately ubiquitinated by the cytosolic protein quality control in the cytosol (PubMed:33792613). {ECO:0000269|PubMed:12056827, ECO:0000269|PubMed:12865408, ECO:0000269|PubMed:15776016, ECO:0000269|PubMed:19424180, ECO:0000269|PubMed:26839314, ECO:0000269|PubMed:27801882, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:32354117, ECO:0000269|PubMed:33792613, ECO:0000269|PubMed:35063767}. |
| Q9Y446 | PKP3 | T159 | ochoa | Plakophilin-3 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250|UniProtKB:Q9QY23, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:34058472}. |
| Q9Y666 | SLC12A7 | T25 | ochoa | Solute carrier family 12 member 7 (Electroneutral potassium-chloride cotransporter 4) (K-Cl cotransporter 4) | Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:10913127). May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity). {ECO:0000250, ECO:0000269|PubMed:10913127}. |
| Q9Y6M4 | CSNK1G3 | T399 | ochoa | Casein kinase I isoform gamma-3 (CKI-gamma 3) (EC 2.7.11.1) | Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). {ECO:0000250}. |
| Q9Y6M5 | SLC30A1 | T449 | ochoa | Proton-coupled zinc antiporter SLC30A1 (Solute carrier family 30 member 1) (Zinc transporter 1) | Zinc ion:proton antiporter that could function at the plasma membrane mediating zinc efflux from cells against its electrochemical gradient protecting them from intracellular zinc accumulation and toxicity (PubMed:31471319). Alternatively, could prevent the transport to the plasma membrane of CACNB2, the L-type calcium channels regulatory subunit, through a yet to be defined mechanism. By modulating the expression of these channels at the plasma membrane, could prevent calcium and zinc influx into cells. By the same mechanism, could also prevent L-type calcium channels-mediated heavy metal influx into cells (By similarity). In some cells, could also function as a zinc ion:proton antiporter mediating zinc entry into the lumen of cytoplasmic vesicles. In macrophages, can increase zinc ions concentration into the lumen of cytoplasmic vesicles containing engulfed bacteria and could help inactivate them (PubMed:32441444). Forms a complex with TMC6/EVER1 and TMC8/EVER2 at the ER membrane of keratynocytes which facilitates zinc uptake into the ER (PubMed:18158319). Down-regulates the activity of transcription factors induced by zinc and cytokines (PubMed:18158319). {ECO:0000250|UniProtKB:Q62720, ECO:0000269|PubMed:18158319, ECO:0000269|PubMed:31471319, ECO:0000269|PubMed:32441444}. |
| Q9Y6Q9 | NCOA3 | T1114 | psp | Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. |
| P38646 | HSPA9 | T94 | Sugiyama | Stress-70 protein, mitochondrial (EC 3.6.4.10) (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Heat shock protein family A member 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74) | Mitochondrial chaperone that plays a key role in mitochondrial protein import, folding, and assembly. Plays an essential role in the protein quality control system, the correct folding of proteins, the re-folding of misfolded proteins, and the targeting of proteins for subsequent degradation. These processes are achieved through cycles of ATP binding, ATP hydrolysis, and ADP release, mediated by co-chaperones (PubMed:18632665, PubMed:25615450, PubMed:28848044, PubMed:30933555, PubMed:31177526). In mitochondria, it associates with the TIM (translocase of the inner membrane) protein complex to assist in the import and folding of mitochondrial proteins (By similarity). Plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis, interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:26702583). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823, PubMed:26702583). Regulates mitochondrial calcium-dependent apoptosis by coupling two calcium channels, ITPR1 and VDAC1, at the mitochondria-associated endoplasmic reticulum (ER) membrane to facilitate calcium transport from the ER lumen to the mitochondria intermembrane space, providing calcium for the downstream calcium channel MCU, which releases it into the mitochondrial matrix (By similarity). Although primarily located in the mitochondria, it is also found in other cellular compartments. In the cytosol, it associates with proteins involved in signaling, apoptosis, or senescence. It may play a role in cell cycle regulation via its interaction with and promotion of degradation of TP53 (PubMed:24625977, PubMed:26634371). May play a role in the control of cell proliferation and cellular aging (By similarity). Protects against reactive oxygen species (ROS) (By similarity). Extracellular HSPA9 plays a cytoprotective role by preventing cell lysis following immune attack by the membrane attack complex by disrupting formation of the complex (PubMed:16091382). {ECO:0000250|UniProtKB:P0CS90, ECO:0000250|UniProtKB:P38647, ECO:0000269|PubMed:16091382, ECO:0000269|PubMed:18632665, ECO:0000269|PubMed:21123823, ECO:0000269|PubMed:24625977, ECO:0000269|PubMed:25615450, ECO:0000269|PubMed:26634371, ECO:0000269|PubMed:26702583, ECO:0000269|PubMed:28848044, ECO:0000269|PubMed:30933555, ECO:0000269|PubMed:31177526}. |
| P49720 | PSMB3 | T105 | Sugiyama | Proteasome subunit beta type-3 (Proteasome chain 13) (Proteasome component C10-II) (Proteasome subunit beta-3) (beta-3) (Proteasome theta chain) | Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| Q02790 | FKBP4 | T106 | Sugiyama | Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed] | Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Also acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. {ECO:0000269|PubMed:1279700, ECO:0000269|PubMed:1376003, ECO:0000269|PubMed:19945390, ECO:0000269|PubMed:21730050, ECO:0000269|PubMed:2378870}. |
| Q14195 | DPYSL3 | T508 | EPSD | Dihydropyrimidinase-related protein 3 (DRP-3) (Collapsin response mediator protein 4) (CRMP-4) (Unc-33-like phosphoprotein 1) (ULIP-1) | Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity). {ECO:0000250}. |
| Q8WUF5 | PPP1R13L | T570 | Sugiyama | RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein) | Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900, ECO:0000269|PubMed:28069640}. |
| Q92530 | PSMF1 | T162 | Sugiyama | Proteasome inhibitor PI31 subunit (hPI31) | Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28. {ECO:0000269|PubMed:10764772}. |
| P30530 | AXL | T856 | Sugiyama | Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene) | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. {ECO:0000269|PubMed:10403904, ECO:0000269|PubMed:11484958, ECO:0000269|PubMed:12364394, ECO:0000269|PubMed:12490074, ECO:0000269|PubMed:15507525, ECO:0000269|PubMed:15733062, ECO:0000269|PubMed:1656220, ECO:0000269|PubMed:18840707}.; FUNCTION: (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:17005688, ECO:0000269|PubMed:21501828, ECO:0000269|PubMed:22156524, ECO:0000269|PubMed:25277499}.; FUNCTION: (Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:22673088}.; FUNCTION: (Microbial infection) Promotes Zika virus entry in glial cells, Sertoli cells and astrocytes (PubMed:28076778, PubMed:29379210, PubMed:31311882). Additionally, Zika virus potentiates AXL kinase activity to antagonize type I interferon signaling and thereby promotes infection (PubMed:28076778). Interferon signaling inhibition occurs via an SOCS1-dependent mechanism (PubMed:29379210). {ECO:0000269|PubMed:28076778, ECO:0000269|PubMed:29379210, ECO:0000269|PubMed:31311882}. |
| Q96PE2 | ARHGEF17 | T1007 | EPSD|PSP | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
| Q07020 | RPL18 | T122 | Sugiyama | Large ribosomal subunit protein eL18 (60S ribosomal protein L18) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
| P33240 | CSTF2 | T333 | Sugiyama | Cleavage stimulation factor subunit 2 (CF-1 64 kDa subunit) (Cleavage stimulation factor 64 kDa subunit) (CSTF 64 kDa subunit) (CstF-64) | One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs. {ECO:0000269|PubMed:32816001, ECO:0000269|PubMed:9199325}. |
| P33240 | CSTF2 | T338 | Sugiyama | Cleavage stimulation factor subunit 2 (CF-1 64 kDa subunit) (Cleavage stimulation factor 64 kDa subunit) (CSTF 64 kDa subunit) (CstF-64) | One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs. {ECO:0000269|PubMed:32816001, ECO:0000269|PubMed:9199325}. |
| Q9H0L4 | CSTF2T | T341 | Sugiyama | Cleavage stimulation factor subunit 2 tau variant (CF-1 64 kDa subunit tau variant) (Cleavage stimulation factor 64 kDa subunit tau variant) (CSTF 64 kDa subunit tau variant) (TauCstF-64) | May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs (By similarity). {ECO:0000250}. |
| Q9H0L4 | CSTF2T | T346 | Sugiyama | Cleavage stimulation factor subunit 2 tau variant (CF-1 64 kDa subunit tau variant) (Cleavage stimulation factor 64 kDa subunit tau variant) (CSTF 64 kDa subunit tau variant) (TauCstF-64) | May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs (By similarity). {ECO:0000250}. |
| Q96T76 | MMS19 | T45 | Sugiyama | MMS19 nucleotide excision repair protein homolog (hMMS19) (MET18 homolog) (MMS19-like protein) | Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity (PubMed:29848660). In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER), homologous recombination-mediated double-strand break DNA repair, DNA replication and RNA polymerase II (POL II) transcription (PubMed:22678361, PubMed:22678362, PubMed:23585563, PubMed:29225034). As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur (Fe-S) cluster assembly into ERCC2/XPD (PubMed:20797633). Together with CIAO2, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis (PubMed:29848660). Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery (PubMed:11279242). {ECO:0000269|PubMed:11279242, ECO:0000269|PubMed:20797633, ECO:0000269|PubMed:22678361, ECO:0000269|PubMed:22678362, ECO:0000269|PubMed:23585563, ECO:0000269|PubMed:29225034, ECO:0000269|PubMed:29848660}. |
| P42224 | STAT1 | T643 | Sugiyama | Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84) | Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors (PubMed:12764129, PubMed:12855578, PubMed:15322115, PubMed:23940278, PubMed:34508746, PubMed:35568036, PubMed:9724754). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus (PubMed:28753426, PubMed:35568036). ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state (PubMed:28753426, PubMed:35568036). In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated (PubMed:26479788). It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state (PubMed:8156998). Becomes activated in response to KITLG/SCF and KIT signaling (PubMed:15526160). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:19088846). Following bacterial lipopolysaccharide (LPS)-induced TLR4 endocytosis, phosphorylated at Thr-749 by IKBKB which promotes binding of STAT1 to the 5'-TTTGAGGC-3' sequence in the ARID5A promoter, resulting in transcriptional activation of ARID5A and subsequent ARID5A-mediated stabilization of IL6 (PubMed:32209697). Phosphorylation at Thr-749 also promotes binding of STAT1 to the 5'-TTTGAGTC-3' sequence in the IL12B promoter and activation of IL12B transcription (PubMed:32209697). Involved in food tolerance in small intestine: associates with the Gasdermin-D, p13 cleavage product (13 kDa GSDMD) and promotes transcription of CIITA, inducing type 1 regulatory T (Tr1) cells in upper small intestine (By similarity). {ECO:0000250|UniProtKB:P42225, ECO:0000269|PubMed:12764129, ECO:0000269|PubMed:12855578, ECO:0000269|PubMed:15322115, ECO:0000269|PubMed:19088846, ECO:0000269|PubMed:23940278, ECO:0000269|PubMed:26479788, ECO:0000269|PubMed:28753426, ECO:0000269|PubMed:32209697, ECO:0000269|PubMed:34508746, ECO:0000269|PubMed:35568036, ECO:0000269|PubMed:8156998, ECO:0000269|PubMed:9724754, ECO:0000303|PubMed:15526160}. |
| Q32MK0 | MYLK3 | T359 | Sugiyama | Myosin light chain kinase 3 (EC 2.7.11.18) (Cardiac-MyBP-C-associated Ca/CaM kinase) (Cardiac-MLCK) | Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity). {ECO:0000250}. |
| Q32MK0 | MYLK3 | T361 | Sugiyama | Myosin light chain kinase 3 (EC 2.7.11.18) (Cardiac-MyBP-C-associated Ca/CaM kinase) (Cardiac-MLCK) | Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity). {ECO:0000250}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.000003 | 5.580 |
| R-HSA-3371556 | Cellular response to heat stress | 0.000002 | 5.632 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.000029 | 4.544 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.000033 | 4.479 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.000033 | 4.479 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.000044 | 4.353 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.000044 | 4.353 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.000051 | 4.293 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.000051 | 4.293 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.000058 | 4.234 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.000067 | 4.177 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.000066 | 4.181 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.000086 | 4.067 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.000097 | 4.014 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.000109 | 3.963 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.000122 | 3.913 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.000122 | 3.913 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.000122 | 3.913 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.000109 | 3.963 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.000138 | 3.860 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.000137 | 3.863 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.000151 | 3.822 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.000232 | 3.634 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.000257 | 3.591 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.000366 | 3.436 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.000525 | 3.280 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.000619 | 3.209 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.000676 | 3.170 |
| R-HSA-191859 | snRNP Assembly | 0.000790 | 3.103 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.000790 | 3.103 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.000876 | 3.057 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.000941 | 3.027 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.001248 | 2.904 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.001192 | 2.924 |
| R-HSA-168255 | Influenza Infection | 0.001438 | 2.842 |
| R-HSA-162582 | Signal Transduction | 0.001741 | 2.759 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.001931 | 2.714 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.001942 | 2.712 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.002053 | 2.688 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.002327 | 2.633 |
| R-HSA-1059683 | Interleukin-6 signaling | 0.002665 | 2.574 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.002665 | 2.574 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 0.002986 | 2.525 |
| R-HSA-211000 | Gene Silencing by RNA | 0.003222 | 2.492 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.003437 | 2.464 |
| R-HSA-74160 | Gene expression (Transcription) | 0.003615 | 2.442 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.004462 | 2.350 |
| R-HSA-8953854 | Metabolism of RNA | 0.005420 | 2.266 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.005650 | 2.248 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.005732 | 2.242 |
| R-HSA-73887 | Death Receptor Signaling | 0.006781 | 2.169 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.007075 | 2.150 |
| R-HSA-162587 | HIV Life Cycle | 0.007482 | 2.126 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.008110 | 2.091 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.008588 | 2.066 |
| R-HSA-3214847 | HATs acetylate histones | 0.008841 | 2.053 |
| R-HSA-8939211 | ESR-mediated signaling | 0.008757 | 2.058 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.009363 | 2.029 |
| R-HSA-70171 | Glycolysis | 0.009215 | 2.036 |
| R-HSA-4839726 | Chromatin organization | 0.011752 | 1.930 |
| R-HSA-68886 | M Phase | 0.013284 | 1.877 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.012533 | 1.902 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.012533 | 1.902 |
| R-HSA-6783589 | Interleukin-6 family signaling | 0.012599 | 1.900 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.012737 | 1.895 |
| R-HSA-913531 | Interferon Signaling | 0.013532 | 1.869 |
| R-HSA-8985947 | Interleukin-9 signaling | 0.013578 | 1.867 |
| R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 0.013578 | 1.867 |
| R-HSA-9839394 | TGFBR3 expression | 0.013742 | 1.862 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.014942 | 1.826 |
| R-HSA-525793 | Myogenesis | 0.014942 | 1.826 |
| R-HSA-2262752 | Cellular responses to stress | 0.015360 | 1.814 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.015993 | 1.796 |
| R-HSA-9020958 | Interleukin-21 signaling | 0.015993 | 1.796 |
| R-HSA-2025928 | Calcineurin activates NFAT | 0.015993 | 1.796 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.017972 | 1.745 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.017972 | 1.745 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.018890 | 1.724 |
| R-HSA-162906 | HIV Infection | 0.018400 | 1.735 |
| R-HSA-70326 | Glucose metabolism | 0.019250 | 1.716 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.019744 | 1.705 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.019827 | 1.703 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.021888 | 1.660 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.022607 | 1.646 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.022858 | 1.641 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.021888 | 1.660 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.020548 | 1.687 |
| R-HSA-68875 | Mitotic Prophase | 0.021219 | 1.673 |
| R-HSA-9679506 | SARS-CoV Infections | 0.023009 | 1.638 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.024965 | 1.603 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.026752 | 1.573 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.027382 | 1.563 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 0.033824 | 1.471 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.033371 | 1.477 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.033824 | 1.471 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.033824 | 1.471 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.030482 | 1.516 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.031969 | 1.495 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.032294 | 1.491 |
| R-HSA-72306 | tRNA processing | 0.032852 | 1.483 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.034115 | 1.467 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.035549 | 1.449 |
| R-HSA-68882 | Mitotic Anaphase | 0.036548 | 1.437 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.036952 | 1.432 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.037312 | 1.428 |
| R-HSA-3371568 | Attenuation phase | 0.039891 | 1.399 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.040911 | 1.388 |
| R-HSA-418990 | Adherens junctions interactions | 0.038088 | 1.419 |
| R-HSA-1500931 | Cell-Cell communication | 0.044180 | 1.355 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.041455 | 1.382 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.044233 | 1.354 |
| R-HSA-1640170 | Cell Cycle | 0.044599 | 1.351 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.044645 | 1.350 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.044683 | 1.350 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.045372 | 1.343 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.046422 | 1.333 |
| R-HSA-9845622 | Defective VWF binding to collagen type I | 0.046578 | 1.332 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.056553 | 1.248 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.056553 | 1.248 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.055895 | 1.253 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.058117 | 1.236 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.058117 | 1.236 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.058530 | 1.233 |
| R-HSA-392517 | Rap1 signalling | 0.056553 | 1.248 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.053117 | 1.275 |
| R-HSA-68877 | Mitotic Prometaphase | 0.054533 | 1.263 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.055895 | 1.253 |
| R-HSA-446728 | Cell junction organization | 0.050622 | 1.296 |
| R-HSA-9609690 | HCMV Early Events | 0.057892 | 1.237 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.054915 | 1.260 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.049621 | 1.304 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.055895 | 1.253 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.059647 | 1.224 |
| R-HSA-9845621 | Defective VWF cleavage by ADAMTS13 variant | 0.061618 | 1.210 |
| R-HSA-9845619 | Enhanced cleavage of VWF variant by ADAMTS13 | 0.061618 | 1.210 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.062429 | 1.205 |
| R-HSA-9610379 | HCMV Late Events | 0.062517 | 1.204 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.065997 | 1.180 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.066380 | 1.178 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.076423 | 1.117 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.076423 | 1.117 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.078484 | 1.105 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.078484 | 1.105 |
| R-HSA-429947 | Deadenylation of mRNA | 0.083146 | 1.080 |
| R-HSA-72649 | Translation initiation complex formation | 0.077327 | 1.112 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.069425 | 1.158 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.068915 | 1.162 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.083146 | 1.080 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.073909 | 1.131 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.072431 | 1.140 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.073909 | 1.131 |
| R-HSA-8854691 | Interleukin-20 family signaling | 0.078484 | 1.105 |
| R-HSA-421270 | Cell-cell junction organization | 0.069958 | 1.155 |
| R-HSA-844455 | The NLRP1 inflammasome | 0.076423 | 1.117 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 0.073909 | 1.131 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.069425 | 1.158 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.073909 | 1.131 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.078340 | 1.106 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.066661 | 1.176 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.069425 | 1.158 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.078484 | 1.105 |
| R-HSA-5619102 | SLC transporter disorders | 0.076940 | 1.114 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.083172 | 1.080 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.083172 | 1.080 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.083172 | 1.080 |
| R-HSA-75893 | TNF signaling | 0.083172 | 1.080 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.105337 | 0.977 |
| R-HSA-9846298 | Defective binding of VWF variant to GPIb:IX:V | 0.105337 | 0.977 |
| R-HSA-9845620 | Enhanced binding of GP1BA variant to VWF multimer:collagen | 0.105337 | 0.977 |
| R-HSA-9706377 | FLT3 signaling by CBL mutants | 0.105337 | 0.977 |
| R-HSA-9823587 | Defects of platelet adhesion to exposed collagen | 0.119454 | 0.923 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.119454 | 0.923 |
| R-HSA-9017802 | Noncanonical activation of NOTCH3 | 0.119454 | 0.923 |
| R-HSA-9842640 | Signaling by LTK in cancer | 0.133349 | 0.875 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 0.147026 | 0.833 |
| R-HSA-9632974 | NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis | 0.147026 | 0.833 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.147026 | 0.833 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.160488 | 0.795 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 0.160488 | 0.795 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.160488 | 0.795 |
| R-HSA-201688 | WNT mediated activation of DVL | 0.173738 | 0.760 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 0.199616 | 0.700 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.224687 | 0.648 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.097609 | 1.011 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.097609 | 1.011 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.102578 | 0.989 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.102578 | 0.989 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.102578 | 0.989 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.102578 | 0.989 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.236928 | 0.625 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 0.260835 | 0.584 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 0.283995 | 0.547 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.172232 | 0.764 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.183554 | 0.736 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.183554 | 0.736 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 0.328170 | 0.484 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.328170 | 0.484 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.212276 | 0.673 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.125917 | 0.900 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.247241 | 0.607 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.253096 | 0.597 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.253096 | 0.597 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.213669 | 0.670 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.217784 | 0.662 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.234398 | 0.630 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.238587 | 0.622 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.126366 | 0.898 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.311580 | 0.506 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.311580 | 0.506 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.323194 | 0.491 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.328983 | 0.483 |
| R-HSA-72172 | mRNA Splicing | 0.149191 | 0.826 |
| R-HSA-192823 | Viral mRNA Translation | 0.272503 | 0.565 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.293962 | 0.532 |
| R-HSA-167172 | Transcription of the HIV genome | 0.340520 | 0.468 |
| R-HSA-167169 | HIV Transcription Elongation | 0.172232 | 0.764 |
| R-HSA-72086 | mRNA Capping | 0.107615 | 0.968 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.234233 | 0.630 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.172232 | 0.764 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.212276 | 0.673 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.212276 | 0.673 |
| R-HSA-2243919 | Crosslinking of collagen fibrils | 0.317388 | 0.498 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.183554 | 0.736 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.315527 | 0.501 |
| R-HSA-8983432 | Interleukin-15 signaling | 0.224687 | 0.648 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.186780 | 0.729 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.199616 | 0.700 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.166616 | 0.778 |
| R-HSA-156902 | Peptide chain elongation | 0.201433 | 0.696 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.315527 | 0.501 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.172232 | 0.764 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.212276 | 0.673 |
| R-HSA-5635851 | GLI proteins bind promoters of Hh responsive genes to promote transcription | 0.119454 | 0.923 |
| R-HSA-75892 | Platelet Adhesion to exposed collagen | 0.236928 | 0.625 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 0.236928 | 0.625 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.149978 | 0.824 |
| R-HSA-9020558 | Interleukin-2 signaling | 0.199616 | 0.700 |
| R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 0.105337 | 0.977 |
| R-HSA-426496 | Post-transcriptional silencing by small RNAs | 0.105337 | 0.977 |
| R-HSA-8849473 | PTK6 Expression | 0.147026 | 0.833 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 0.248976 | 0.604 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 0.272507 | 0.565 |
| R-HSA-9664420 | Killing mechanisms | 0.272507 | 0.565 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.155487 | 0.808 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.092284 | 1.035 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.183554 | 0.736 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.125917 | 0.900 |
| R-HSA-72187 | mRNA 3'-end processing | 0.247241 | 0.607 |
| R-HSA-5689603 | UCH proteinases | 0.150708 | 0.822 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.281069 | 0.551 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.281069 | 0.551 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.260835 | 0.584 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.248976 | 0.604 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.260835 | 0.584 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.115911 | 0.936 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.238587 | 0.622 |
| R-HSA-4641258 | Degradation of DVL | 0.155487 | 0.808 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.177879 | 0.750 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.253096 | 0.597 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 0.173738 | 0.760 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.118445 | 0.926 |
| R-HSA-390696 | Adrenoceptors | 0.160488 | 0.795 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 0.160488 | 0.795 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 0.173738 | 0.760 |
| R-HSA-877312 | Regulation of IFNG signaling | 0.224687 | 0.648 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.139086 | 0.857 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.086164 | 1.065 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 0.317388 | 0.498 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.241391 | 0.617 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.299925 | 0.523 |
| R-HSA-6807070 | PTEN Regulation | 0.237623 | 0.624 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.306433 | 0.514 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.102423 | 0.990 |
| R-HSA-8984722 | Interleukin-35 Signalling | 0.224687 | 0.648 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.132447 | 0.878 |
| R-HSA-9907900 | Proteasome assembly | 0.200726 | 0.697 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.221914 | 0.654 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.337124 | 0.472 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.184526 | 0.734 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.328170 | 0.484 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.181439 | 0.741 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.147026 | 0.833 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.128379 | 0.892 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.288239 | 0.540 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.234233 | 0.630 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 0.173738 | 0.760 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 0.119454 | 0.923 |
| R-HSA-1433617 | Regulation of signaling by NODAL | 0.173738 | 0.760 |
| R-HSA-1483226 | Synthesis of PI | 0.199616 | 0.700 |
| R-HSA-2142712 | Synthesis of 12-eicosatetraenoic acid derivatives | 0.260835 | 0.584 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.139086 | 0.857 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 0.306433 | 0.514 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.212276 | 0.673 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.246591 | 0.608 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.223889 | 0.650 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 0.160488 | 0.795 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.260835 | 0.584 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.154453 | 0.811 |
| R-HSA-9766229 | Degradation of CDH1 | 0.229713 | 0.639 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.323194 | 0.491 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.289655 | 0.538 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 0.186780 | 0.729 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.248976 | 0.604 |
| R-HSA-983189 | Kinesins | 0.294085 | 0.532 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.263967 | 0.578 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.098578 | 1.006 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.260835 | 0.584 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.087652 | 1.057 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.144510 | 0.840 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.231748 | 0.635 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 0.105337 | 0.977 |
| R-HSA-426117 | Cation-coupled Chloride cotransporters | 0.147026 | 0.833 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 0.160488 | 0.795 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.173738 | 0.760 |
| R-HSA-9020956 | Interleukin-27 signaling | 0.186780 | 0.729 |
| R-HSA-2214320 | Anchoring fibril formation | 0.212251 | 0.673 |
| R-HSA-428540 | Activation of RAC1 | 0.212251 | 0.673 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.236928 | 0.625 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.260835 | 0.584 |
| R-HSA-1566977 | Fibronectin matrix formation | 0.283995 | 0.547 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.155487 | 0.808 |
| R-HSA-2142770 | Synthesis of 15-eicosatetraenoic acid derivatives | 0.295303 | 0.530 |
| R-HSA-2142688 | Synthesis of 5-eicosatetraenoic acids | 0.317388 | 0.498 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.282387 | 0.549 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.276783 | 0.558 |
| R-HSA-449147 | Signaling by Interleukins | 0.151571 | 0.819 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 0.186780 | 0.729 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.149978 | 0.824 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.307365 | 0.512 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.144510 | 0.840 |
| R-HSA-9671793 | Diseases of hemostasis | 0.317388 | 0.498 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 0.173738 | 0.760 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.119454 | 0.923 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 0.260835 | 0.584 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.128893 | 0.890 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.112598 | 0.948 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.294085 | 0.532 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.234897 | 0.629 |
| R-HSA-195721 | Signaling by WNT | 0.137149 | 0.863 |
| R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 0.272507 | 0.565 |
| R-HSA-9945266 | Differentiation of T cells | 0.272507 | 0.565 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.295303 | 0.530 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.128379 | 0.892 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.283995 | 0.547 |
| R-HSA-1181150 | Signaling by NODAL | 0.328170 | 0.484 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.258953 | 0.587 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.198106 | 0.703 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.298139 | 0.526 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.264813 | 0.577 |
| R-HSA-9609646 | HCMV Infection | 0.141580 | 0.849 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.112717 | 0.948 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.197392 | 0.705 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.105619 | 0.976 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 0.236928 | 0.625 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.286130 | 0.543 |
| R-HSA-8849468 | PTK6 Regulates Proteins Involved in RNA Processing | 0.105337 | 0.977 |
| R-HSA-435368 | Zinc efflux and compartmentalization by the SLC30 family | 0.105337 | 0.977 |
| R-HSA-9635465 | Suppression of apoptosis | 0.199616 | 0.700 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.260835 | 0.584 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 0.260835 | 0.584 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 0.260835 | 0.584 |
| R-HSA-3371511 | HSF1 activation | 0.149978 | 0.824 |
| R-HSA-198753 | ERK/MAPK targets | 0.338783 | 0.470 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.340520 | 0.468 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.128893 | 0.890 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.236172 | 0.627 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.177879 | 0.750 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.338783 | 0.470 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.338783 | 0.470 |
| R-HSA-422085 | Synthesis, secretion, and deacylation of Ghrelin | 0.338783 | 0.470 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.270673 | 0.568 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.328983 | 0.483 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.279100 | 0.554 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.317388 | 0.498 |
| R-HSA-212436 | Generic Transcription Pathway | 0.125284 | 0.902 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.213669 | 0.670 |
| R-HSA-9824446 | Viral Infection Pathways | 0.211005 | 0.676 |
| R-HSA-165159 | MTOR signalling | 0.189255 | 0.723 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.097609 | 1.011 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.105040 | 0.979 |
| R-HSA-8848021 | Signaling by PTK6 | 0.105040 | 0.979 |
| R-HSA-9607240 | FLT3 Signaling | 0.177879 | 0.750 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.306433 | 0.514 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.101788 | 0.992 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.095085 | 1.022 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.242789 | 0.615 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.151449 | 0.820 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.279100 | 0.554 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.102578 | 0.989 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.212246 | 0.673 |
| R-HSA-194138 | Signaling by VEGF | 0.185045 | 0.733 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.092712 | 1.033 |
| R-HSA-435354 | Zinc transporters | 0.248976 | 0.604 |
| R-HSA-373753 | Nephrin family interactions | 0.328170 | 0.484 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.263967 | 0.578 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.247691 | 0.606 |
| R-HSA-373755 | Semaphorin interactions | 0.311580 | 0.506 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.112717 | 0.948 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.306433 | 0.514 |
| R-HSA-437239 | Recycling pathway of L1 | 0.218076 | 0.661 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.279470 | 0.554 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.282612 | 0.549 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.169476 | 0.771 |
| R-HSA-109581 | Apoptosis | 0.321613 | 0.493 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.295303 | 0.530 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.295303 | 0.530 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.289660 | 0.538 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.149978 | 0.824 |
| R-HSA-1483255 | PI Metabolism | 0.268231 | 0.571 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.323194 | 0.491 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.135976 | 0.867 |
| R-HSA-373760 | L1CAM interactions | 0.341441 | 0.467 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.349229 | 0.457 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.349229 | 0.457 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 0.349229 | 0.457 |
| R-HSA-5693538 | Homology Directed Repair | 0.350069 | 0.456 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.357398 | 0.447 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.357706 | 0.446 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.357706 | 0.446 |
| R-HSA-6803529 | FGFR2 alternative splicing | 0.359510 | 0.444 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.359510 | 0.444 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 0.359510 | 0.444 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.359510 | 0.444 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.359510 | 0.444 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.360981 | 0.443 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.363400 | 0.440 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.363400 | 0.440 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.369074 | 0.433 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 0.369630 | 0.432 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.369630 | 0.432 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.369630 | 0.432 |
| R-HSA-3000170 | Syndecan interactions | 0.369630 | 0.432 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.369630 | 0.432 |
| R-HSA-72312 | rRNA processing | 0.372382 | 0.429 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.374729 | 0.426 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.374729 | 0.426 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.374729 | 0.426 |
| R-HSA-199991 | Membrane Trafficking | 0.376367 | 0.424 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.379590 | 0.421 |
| R-HSA-9865881 | Complex III assembly | 0.379590 | 0.421 |
| R-HSA-380287 | Centrosome maturation | 0.380363 | 0.420 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.384424 | 0.415 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.384424 | 0.415 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.384424 | 0.415 |
| R-HSA-69206 | G1/S Transition | 0.384424 | 0.415 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.385975 | 0.413 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.389393 | 0.410 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.389393 | 0.410 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.389393 | 0.410 |
| R-HSA-3214842 | HDMs demethylate histones | 0.389393 | 0.410 |
| R-HSA-2559583 | Cellular Senescence | 0.389601 | 0.409 |
| R-HSA-69481 | G2/M Checkpoints | 0.392955 | 0.406 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.397133 | 0.401 |
| R-HSA-4086400 | PCP/CE pathway | 0.397133 | 0.401 |
| R-HSA-157118 | Signaling by NOTCH | 0.397413 | 0.401 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.399043 | 0.399 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.399043 | 0.399 |
| R-HSA-8874081 | MET activates PTK2 signaling | 0.399043 | 0.399 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.399043 | 0.399 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.399043 | 0.399 |
| R-HSA-9659379 | Sensory processing of sound | 0.402677 | 0.395 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.408197 | 0.389 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.408197 | 0.389 |
| R-HSA-6806834 | Signaling by MET | 0.408197 | 0.389 |
| R-HSA-9833482 | PKR-mediated signaling | 0.408197 | 0.389 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.408540 | 0.389 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.408540 | 0.389 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.408540 | 0.389 |
| R-HSA-8949613 | Cristae formation | 0.408540 | 0.389 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.408540 | 0.389 |
| R-HSA-69275 | G2/M Transition | 0.410959 | 0.386 |
| R-HSA-422475 | Axon guidance | 0.412319 | 0.385 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.413692 | 0.383 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.417888 | 0.379 |
| R-HSA-622312 | Inflammasomes | 0.417888 | 0.379 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.418046 | 0.379 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.427088 | 0.369 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.427088 | 0.369 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.427088 | 0.369 |
| R-HSA-180024 | DARPP-32 events | 0.427088 | 0.369 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.427088 | 0.369 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.435414 | 0.361 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.436144 | 0.360 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.436144 | 0.360 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.436144 | 0.360 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.436144 | 0.360 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.439254 | 0.357 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.440777 | 0.356 |
| R-HSA-5688426 | Deubiquitination | 0.444027 | 0.353 |
| R-HSA-182971 | EGFR downregulation | 0.445057 | 0.352 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.445057 | 0.352 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.445057 | 0.352 |
| R-HSA-186763 | Downstream signal transduction | 0.445057 | 0.352 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.453830 | 0.343 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.453830 | 0.343 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.456696 | 0.340 |
| R-HSA-9663891 | Selective autophagy | 0.456696 | 0.340 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.460102 | 0.337 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.462465 | 0.335 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.462465 | 0.335 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.462465 | 0.335 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.462465 | 0.335 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.467164 | 0.331 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.470963 | 0.327 |
| R-HSA-5673000 | RAF activation | 0.479328 | 0.319 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.479328 | 0.319 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.479328 | 0.319 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.479328 | 0.319 |
| R-HSA-5205647 | Mitophagy | 0.479328 | 0.319 |
| R-HSA-5357801 | Programmed Cell Death | 0.480748 | 0.318 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.483715 | 0.315 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.484159 | 0.315 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.487561 | 0.312 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.487561 | 0.312 |
| R-HSA-169911 | Regulation of Apoptosis | 0.487561 | 0.312 |
| R-HSA-9675108 | Nervous system development | 0.490811 | 0.309 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.495665 | 0.305 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.495665 | 0.305 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.495665 | 0.305 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.495665 | 0.305 |
| R-HSA-111933 | Calmodulin induced events | 0.495665 | 0.305 |
| R-HSA-111997 | CaM pathway | 0.495665 | 0.305 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 0.495665 | 0.305 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.502836 | 0.299 |
| R-HSA-4641257 | Degradation of AXIN | 0.503640 | 0.298 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.503640 | 0.298 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 0.503640 | 0.298 |
| R-HSA-8948216 | Collagen chain trimerization | 0.503640 | 0.298 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.507784 | 0.294 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.507806 | 0.294 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.507806 | 0.294 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.507925 | 0.294 |
| R-HSA-8875878 | MET promotes cell motility | 0.511490 | 0.291 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.511490 | 0.291 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.511490 | 0.291 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.515633 | 0.288 |
| R-HSA-190236 | Signaling by FGFR | 0.517648 | 0.286 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.519217 | 0.285 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.519217 | 0.285 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.519217 | 0.285 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.519217 | 0.285 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.519217 | 0.285 |
| R-HSA-201556 | Signaling by ALK | 0.519217 | 0.285 |
| R-HSA-69541 | Stabilization of p53 | 0.519217 | 0.285 |
| R-HSA-1989781 | PPARA activates gene expression | 0.519594 | 0.284 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.522520 | 0.282 |
| R-HSA-9646399 | Aggrephagy | 0.526821 | 0.278 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.526821 | 0.278 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.526821 | 0.278 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.526821 | 0.278 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.527290 | 0.278 |
| R-HSA-9711097 | Cellular response to starvation | 0.531113 | 0.275 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.534306 | 0.272 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.534306 | 0.272 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.534306 | 0.272 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.534306 | 0.272 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.534306 | 0.272 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.534306 | 0.272 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.534306 | 0.272 |
| R-HSA-877300 | Interferon gamma signaling | 0.534918 | 0.272 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.536937 | 0.270 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.536937 | 0.270 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.536937 | 0.270 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.538706 | 0.269 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.541673 | 0.266 |
| R-HSA-167161 | HIV Transcription Initiation | 0.541673 | 0.266 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.541673 | 0.266 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.541673 | 0.266 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.541673 | 0.266 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.541673 | 0.266 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 0.541673 | 0.266 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.541673 | 0.266 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.545578 | 0.263 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.546382 | 0.263 |
| R-HSA-111885 | Opioid Signalling | 0.546382 | 0.263 |
| R-HSA-5663205 | Infectious disease | 0.547369 | 0.262 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.548924 | 0.260 |
| R-HSA-111996 | Ca-dependent events | 0.548924 | 0.260 |
| R-HSA-168256 | Immune System | 0.552190 | 0.258 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.553680 | 0.257 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.556061 | 0.255 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.556061 | 0.255 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.556061 | 0.255 |
| R-HSA-8854214 | TBC/RABGAPs | 0.556061 | 0.255 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.556061 | 0.255 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 0.556061 | 0.255 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.559841 | 0.252 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.562613 | 0.250 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.563085 | 0.249 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.563085 | 0.249 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.563085 | 0.249 |
| R-HSA-373752 | Netrin-1 signaling | 0.563085 | 0.249 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.564866 | 0.248 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.564866 | 0.248 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.565422 | 0.248 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.569998 | 0.244 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.569998 | 0.244 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.569998 | 0.244 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.569998 | 0.244 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.569998 | 0.244 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.569998 | 0.244 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.569998 | 0.244 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.569998 | 0.244 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.569998 | 0.244 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.569998 | 0.244 |
| R-HSA-9824272 | Somitogenesis | 0.569998 | 0.244 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.569998 | 0.244 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.576802 | 0.239 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.583500 | 0.234 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.589825 | 0.229 |
| R-HSA-425410 | Metal ion SLC transporters | 0.590091 | 0.229 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.595899 | 0.225 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.595899 | 0.225 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.596579 | 0.224 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.596579 | 0.224 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.596826 | 0.224 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.602964 | 0.220 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.602964 | 0.220 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.608684 | 0.216 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.609249 | 0.215 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.609249 | 0.215 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.615434 | 0.211 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.615434 | 0.211 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.615434 | 0.211 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.615434 | 0.211 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.615434 | 0.211 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.615434 | 0.211 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.617036 | 0.210 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.621522 | 0.207 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.621522 | 0.207 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.621522 | 0.207 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.621522 | 0.207 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.627515 | 0.202 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.633412 | 0.198 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.633412 | 0.198 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.639217 | 0.194 |
| R-HSA-177929 | Signaling by EGFR | 0.639217 | 0.194 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.639217 | 0.194 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.639217 | 0.194 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.639217 | 0.194 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.640514 | 0.193 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.641271 | 0.193 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.641271 | 0.193 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.644930 | 0.190 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.645191 | 0.190 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.656087 | 0.183 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.661533 | 0.179 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.661533 | 0.179 |
| R-HSA-351202 | Metabolism of polyamines | 0.661533 | 0.179 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.661533 | 0.179 |
| R-HSA-1442490 | Collagen degradation | 0.666894 | 0.176 |
| R-HSA-112043 | PLC beta mediated events | 0.666894 | 0.176 |
| R-HSA-445717 | Aquaporin-mediated transport | 0.666894 | 0.176 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.666894 | 0.176 |
| R-HSA-450294 | MAP kinase activation | 0.666894 | 0.176 |
| R-HSA-1268020 | Mitochondrial protein import | 0.672171 | 0.173 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.672171 | 0.173 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.672171 | 0.173 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.672171 | 0.173 |
| R-HSA-9707616 | Heme signaling | 0.672171 | 0.173 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.672171 | 0.173 |
| R-HSA-186797 | Signaling by PDGF | 0.672171 | 0.173 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.677364 | 0.169 |
| R-HSA-6799198 | Complex I biogenesis | 0.677364 | 0.169 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.677364 | 0.169 |
| R-HSA-9843745 | Adipogenesis | 0.678963 | 0.168 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.682475 | 0.166 |
| R-HSA-9909396 | Circadian clock | 0.682549 | 0.166 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.682549 | 0.166 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.686473 | 0.163 |
| R-HSA-112040 | G-protein mediated events | 0.697329 | 0.157 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.702125 | 0.154 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 0.702125 | 0.154 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.706846 | 0.151 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.711491 | 0.148 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.711491 | 0.148 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.711491 | 0.148 |
| R-HSA-448424 | Interleukin-17 signaling | 0.711491 | 0.148 |
| R-HSA-3000178 | ECM proteoglycans | 0.716064 | 0.145 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.716064 | 0.145 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.716064 | 0.145 |
| R-HSA-1632852 | Macroautophagy | 0.716639 | 0.145 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.720564 | 0.142 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 0.720564 | 0.142 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.720564 | 0.142 |
| R-HSA-72766 | Translation | 0.722247 | 0.141 |
| R-HSA-1280218 | Adaptive Immune System | 0.724390 | 0.140 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.724993 | 0.140 |
| R-HSA-4086398 | Ca2+ pathway | 0.724993 | 0.140 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.729353 | 0.137 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.733643 | 0.135 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.733643 | 0.135 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.733643 | 0.135 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.737866 | 0.132 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.737866 | 0.132 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.738637 | 0.132 |
| R-HSA-1483257 | Phospholipid metabolism | 0.738835 | 0.131 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.746112 | 0.127 |
| R-HSA-5619084 | ABC transporter disorders | 0.746112 | 0.127 |
| R-HSA-216083 | Integrin cell surface interactions | 0.746112 | 0.127 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.750138 | 0.125 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.754100 | 0.123 |
| R-HSA-9612973 | Autophagy | 0.764770 | 0.116 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.765615 | 0.116 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.769333 | 0.114 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.769333 | 0.114 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.769954 | 0.114 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.772992 | 0.112 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.776593 | 0.110 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.780137 | 0.108 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.783625 | 0.106 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.790437 | 0.102 |
| R-HSA-73884 | Base Excision Repair | 0.793762 | 0.100 |
| R-HSA-202424 | Downstream TCR signaling | 0.793762 | 0.100 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.797035 | 0.099 |
| R-HSA-418555 | G alpha (s) signalling events | 0.805664 | 0.094 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.806547 | 0.093 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.806547 | 0.093 |
| R-HSA-1474290 | Collagen formation | 0.809617 | 0.092 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.809617 | 0.092 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.818541 | 0.087 |
| R-HSA-1266738 | Developmental Biology | 0.818554 | 0.087 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.821422 | 0.085 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.824258 | 0.084 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.824258 | 0.084 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.824258 | 0.084 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.829795 | 0.081 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.832498 | 0.080 |
| R-HSA-9833110 | RSV-host interactions | 0.842889 | 0.074 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.845385 | 0.073 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.845385 | 0.073 |
| R-HSA-5617833 | Cilium Assembly | 0.845945 | 0.073 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.847562 | 0.072 |
| R-HSA-69239 | Synthesis of DNA | 0.850259 | 0.070 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.852638 | 0.069 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.852638 | 0.069 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.852638 | 0.069 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.852638 | 0.069 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.854980 | 0.068 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.854980 | 0.068 |
| R-HSA-73894 | DNA Repair | 0.855586 | 0.068 |
| R-HSA-202403 | TCR signaling | 0.857284 | 0.067 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.857284 | 0.067 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.857284 | 0.067 |
| R-HSA-6803157 | Antimicrobial peptides | 0.859552 | 0.066 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.860066 | 0.065 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.863966 | 0.064 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.863981 | 0.063 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.863981 | 0.063 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.867330 | 0.062 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.870365 | 0.060 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.870365 | 0.060 |
| R-HSA-6805567 | Keratinization | 0.875412 | 0.058 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.876450 | 0.057 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.878415 | 0.056 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.880348 | 0.055 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.880348 | 0.055 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.884124 | 0.053 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.884512 | 0.053 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.885967 | 0.053 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.885967 | 0.053 |
| R-HSA-114608 | Platelet degranulation | 0.896427 | 0.047 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.898075 | 0.047 |
| R-HSA-597592 | Post-translational protein modification | 0.901326 | 0.045 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.905932 | 0.043 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.907067 | 0.042 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.907429 | 0.042 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.914567 | 0.039 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.918584 | 0.037 |
| R-HSA-9664407 | Parasite infection | 0.918584 | 0.037 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.918584 | 0.037 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.919880 | 0.036 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.924865 | 0.034 |
| R-HSA-69242 | S Phase | 0.929540 | 0.032 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.929540 | 0.032 |
| R-HSA-166520 | Signaling by NTRKs | 0.929540 | 0.032 |
| R-HSA-9758941 | Gastrulation | 0.930663 | 0.031 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.931768 | 0.031 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.933925 | 0.030 |
| R-HSA-2142753 | Arachidonate metabolism | 0.933925 | 0.030 |
| R-HSA-9609507 | Protein localization | 0.934978 | 0.029 |
| R-HSA-69306 | DNA Replication | 0.934978 | 0.029 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.940390 | 0.027 |
| R-HSA-109582 | Hemostasis | 0.944484 | 0.025 |
| R-HSA-6798695 | Neutrophil degranulation | 0.947095 | 0.024 |
| R-HSA-168249 | Innate Immune System | 0.948059 | 0.023 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.953091 | 0.021 |
| R-HSA-9658195 | Leishmania infection | 0.953091 | 0.021 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.954351 | 0.020 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.956295 | 0.019 |
| R-HSA-611105 | Respiratory electron transport | 0.957197 | 0.019 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.959819 | 0.018 |
| R-HSA-983712 | Ion channel transport | 0.964144 | 0.016 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.965281 | 0.015 |
| R-HSA-1643685 | Disease | 0.965877 | 0.015 |
| R-HSA-388396 | GPCR downstream signalling | 0.971055 | 0.013 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.971385 | 0.013 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.973459 | 0.012 |
| R-HSA-397014 | Muscle contraction | 0.975647 | 0.011 |
| R-HSA-392499 | Metabolism of proteins | 0.977793 | 0.010 |
| R-HSA-8951664 | Neddylation | 0.978938 | 0.009 |
| R-HSA-15869 | Metabolism of nucleotides | 0.983469 | 0.007 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.983734 | 0.007 |
| R-HSA-112316 | Neuronal System | 0.984703 | 0.007 |
| R-HSA-372790 | Signaling by GPCR | 0.987288 | 0.006 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.990684 | 0.004 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.991739 | 0.004 |
| R-HSA-418594 | G alpha (i) signalling events | 0.991918 | 0.004 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.993475 | 0.003 |
| R-HSA-8957322 | Metabolism of steroids | 0.996026 | 0.002 |
| R-HSA-1474244 | Extracellular matrix organization | 0.996453 | 0.002 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.996986 | 0.001 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.998749 | 0.001 |
| R-HSA-8978868 | Fatty acid metabolism | 0.998988 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 0.999686 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 0.999949 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999974 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
GCK |
0.847 | 0.159 | 1 | 0.815 |
TNIK |
0.847 | 0.144 | 3 | 0.847 |
GAK |
0.846 | -0.020 | 1 | 0.795 |
MINK |
0.845 | 0.132 | 1 | 0.784 |
KHS1 |
0.845 | 0.178 | 1 | 0.786 |
KHS2 |
0.845 | 0.184 | 1 | 0.807 |
TAK1 |
0.842 | -0.009 | 1 | 0.797 |
LKB1 |
0.839 | 0.155 | -3 | 0.828 |
VRK2 |
0.839 | -0.097 | 1 | 0.792 |
PKR |
0.839 | -0.002 | 1 | 0.766 |
HGK |
0.838 | 0.100 | 3 | 0.844 |
HPK1 |
0.838 | 0.137 | 1 | 0.810 |
NEK1 |
0.836 | 0.021 | 1 | 0.739 |
MST2 |
0.835 | 0.011 | 1 | 0.800 |
VRK1 |
0.834 | -0.123 | 2 | 0.581 |
TAO3 |
0.834 | 0.074 | 1 | 0.766 |
OSR1 |
0.834 | 0.015 | 2 | 0.602 |
EEF2K |
0.834 | -0.009 | 3 | 0.815 |
ASK1 |
0.833 | -0.084 | 1 | 0.718 |
LRRK2 |
0.833 | -0.093 | 2 | 0.621 |
MAP3K15 |
0.832 | -0.013 | 1 | 0.727 |
MYO3B |
0.832 | 0.043 | 2 | 0.634 |
MST1 |
0.831 | -0.011 | 1 | 0.782 |
BMPR2 |
0.831 | 0.019 | -2 | 0.931 |
MEK1 |
0.831 | -0.087 | 2 | 0.621 |
NEK5 |
0.831 | -0.012 | 1 | 0.761 |
MST3 |
0.830 | 0.044 | 2 | 0.633 |
ALK4 |
0.830 | 0.070 | -2 | 0.883 |
BMPR1B |
0.830 | 0.184 | 1 | 0.827 |
PDK1 |
0.830 | -0.034 | 1 | 0.746 |
MEKK2 |
0.829 | -0.075 | 2 | 0.572 |
BRAF |
0.829 | -0.076 | -4 | 0.805 |
MPSK1 |
0.829 | 0.097 | 1 | 0.701 |
CAMKK2 |
0.829 | 0.015 | -2 | 0.810 |
TTK |
0.829 | -0.021 | -2 | 0.882 |
TAO2 |
0.829 | -0.042 | 2 | 0.626 |
MOS |
0.829 | 0.148 | 1 | 0.830 |
MYO3A |
0.828 | 0.005 | 1 | 0.741 |
DAPK2 |
0.828 | 0.029 | -3 | 0.849 |
CAMKK1 |
0.827 | -0.031 | -2 | 0.820 |
PBK |
0.827 | 0.053 | 1 | 0.713 |
NIK |
0.825 | -0.054 | -3 | 0.852 |
MEKK6 |
0.825 | -0.065 | 1 | 0.753 |
NEK4 |
0.825 | 0.009 | 1 | 0.750 |
MEK5 |
0.825 | -0.178 | 2 | 0.601 |
BIKE |
0.825 | -0.002 | 1 | 0.675 |
TGFBR1 |
0.824 | 0.099 | -2 | 0.855 |
ALK2 |
0.823 | 0.051 | -2 | 0.862 |
YSK1 |
0.822 | -0.039 | 2 | 0.603 |
PRPK |
0.822 | -0.028 | -1 | 0.895 |
PRP4 |
0.822 | 0.078 | -3 | 0.809 |
YSK4 |
0.822 | -0.015 | 1 | 0.766 |
DLK |
0.821 | -0.098 | 1 | 0.799 |
ACVR2B |
0.821 | 0.116 | -2 | 0.865 |
JNK2 |
0.820 | 0.044 | 1 | 0.578 |
CAMLCK |
0.820 | -0.016 | -2 | 0.875 |
LATS1 |
0.820 | 0.056 | -3 | 0.852 |
STLK3 |
0.820 | -0.129 | 1 | 0.712 |
NEK11 |
0.820 | -0.078 | 1 | 0.775 |
MEKK1 |
0.820 | -0.102 | 1 | 0.749 |
MEK2 |
0.820 | -0.134 | 2 | 0.601 |
PASK |
0.818 | -0.006 | -3 | 0.854 |
NLK |
0.818 | 0.020 | 1 | 0.772 |
NEK8 |
0.818 | -0.134 | 2 | 0.585 |
AAK1 |
0.817 | 0.041 | 1 | 0.576 |
GRK7 |
0.817 | 0.120 | 1 | 0.772 |
CHAK2 |
0.817 | 0.204 | -1 | 0.854 |
ANKRD3 |
0.816 | -0.131 | 1 | 0.802 |
LOK |
0.816 | 0.015 | -2 | 0.800 |
ATR |
0.816 | 0.005 | 1 | 0.764 |
JNK3 |
0.816 | 0.014 | 1 | 0.606 |
MLK2 |
0.816 | -0.016 | 2 | 0.610 |
ACVR2A |
0.816 | 0.072 | -2 | 0.849 |
CDKL1 |
0.816 | 0.036 | -3 | 0.799 |
ICK |
0.815 | 0.051 | -3 | 0.838 |
ALPHAK3 |
0.815 | -0.092 | -1 | 0.798 |
ZAK |
0.815 | -0.112 | 1 | 0.743 |
CAMK1B |
0.814 | -0.037 | -3 | 0.838 |
P38B |
0.813 | 0.040 | 1 | 0.602 |
P38A |
0.813 | 0.022 | 1 | 0.655 |
BMPR1A |
0.813 | 0.114 | 1 | 0.800 |
TLK2 |
0.813 | 0.048 | 1 | 0.737 |
SKMLCK |
0.812 | 0.053 | -2 | 0.885 |
RAF1 |
0.811 | 0.051 | 1 | 0.831 |
DAPK3 |
0.811 | -0.003 | -3 | 0.785 |
MEKK3 |
0.810 | -0.167 | 1 | 0.772 |
BUB1 |
0.810 | 0.152 | -5 | 0.759 |
PERK |
0.809 | -0.074 | -2 | 0.895 |
COT |
0.809 | 0.094 | 2 | 0.620 |
ERK5 |
0.809 | 0.052 | 1 | 0.774 |
CLK3 |
0.809 | 0.178 | 1 | 0.767 |
CDC7 |
0.809 | 0.206 | 1 | 0.831 |
ROCK2 |
0.809 | 0.026 | -3 | 0.773 |
MAK |
0.808 | 0.116 | -2 | 0.765 |
TAO1 |
0.808 | -0.038 | 1 | 0.690 |
NEK9 |
0.807 | -0.056 | 2 | 0.612 |
PLK1 |
0.806 | -0.026 | -2 | 0.878 |
SLK |
0.805 | -0.002 | -2 | 0.754 |
DMPK1 |
0.805 | -0.007 | -3 | 0.739 |
HIPK1 |
0.805 | 0.071 | 1 | 0.643 |
PIM3 |
0.804 | 0.096 | -3 | 0.833 |
GRK5 |
0.803 | -0.052 | -3 | 0.836 |
NEK2 |
0.803 | -0.014 | 2 | 0.610 |
GRK6 |
0.802 | -0.037 | 1 | 0.835 |
MLK1 |
0.802 | -0.107 | 2 | 0.577 |
P38G |
0.802 | 0.019 | 1 | 0.510 |
CDK5 |
0.802 | 0.044 | 1 | 0.633 |
P38D |
0.801 | 0.047 | 1 | 0.503 |
DSTYK |
0.801 | 0.009 | 2 | 0.641 |
SMMLCK |
0.801 | -0.081 | -3 | 0.797 |
HRI |
0.800 | -0.135 | -2 | 0.907 |
HIPK4 |
0.800 | 0.193 | 1 | 0.701 |
CAMK2G |
0.799 | -0.104 | 2 | 0.584 |
MLK3 |
0.799 | -0.033 | 2 | 0.529 |
MASTL |
0.798 | -0.189 | -2 | 0.869 |
PDHK4 |
0.798 | -0.152 | 1 | 0.819 |
NEK3 |
0.798 | -0.072 | 1 | 0.692 |
PDHK1 |
0.798 | -0.058 | 1 | 0.811 |
DAPK1 |
0.798 | -0.016 | -3 | 0.769 |
MST4 |
0.798 | 0.063 | 2 | 0.677 |
PIM1 |
0.798 | 0.053 | -3 | 0.775 |
ERK7 |
0.797 | -0.017 | 2 | 0.390 |
MTOR |
0.797 | 0.058 | 1 | 0.760 |
CDK1 |
0.797 | 0.043 | 1 | 0.597 |
CDKL5 |
0.797 | 0.055 | -3 | 0.796 |
NEK6 |
0.797 | 0.095 | -2 | 0.926 |
TLK1 |
0.797 | -0.076 | -2 | 0.887 |
PKCD |
0.796 | 0.005 | 2 | 0.562 |
MLK4 |
0.796 | -0.085 | 2 | 0.499 |
DNAPK |
0.796 | 0.029 | 1 | 0.685 |
MOK |
0.796 | 0.066 | 1 | 0.659 |
GRK1 |
0.796 | 0.109 | -2 | 0.832 |
AMPKA1 |
0.796 | 0.029 | -3 | 0.834 |
HASPIN |
0.794 | -0.020 | -1 | 0.725 |
TGFBR2 |
0.794 | 0.042 | -2 | 0.853 |
ERK1 |
0.794 | 0.015 | 1 | 0.585 |
DYRK2 |
0.794 | 0.034 | 1 | 0.631 |
PKN3 |
0.794 | -0.048 | -3 | 0.810 |
TSSK2 |
0.794 | -0.063 | -5 | 0.813 |
DCAMKL1 |
0.794 | -0.027 | -3 | 0.771 |
CHAK1 |
0.793 | -0.005 | 2 | 0.619 |
JNK1 |
0.793 | -0.012 | 1 | 0.575 |
WNK4 |
0.792 | -0.150 | -2 | 0.909 |
IRAK4 |
0.792 | -0.134 | 1 | 0.708 |
TBK1 |
0.792 | 0.038 | 1 | 0.747 |
GRK2 |
0.792 | -0.009 | -2 | 0.770 |
PIM2 |
0.791 | 0.033 | -3 | 0.734 |
NEK7 |
0.791 | -0.044 | -3 | 0.830 |
WNK1 |
0.791 | -0.075 | -2 | 0.907 |
HIPK3 |
0.791 | 0.035 | 1 | 0.639 |
SRPK1 |
0.791 | 0.129 | -3 | 0.759 |
RIPK1 |
0.791 | -0.188 | 1 | 0.741 |
PINK1 |
0.790 | -0.089 | 1 | 0.736 |
NUAK2 |
0.790 | -0.015 | -3 | 0.820 |
ERK2 |
0.789 | -0.057 | 1 | 0.621 |
ULK2 |
0.789 | -0.090 | 2 | 0.558 |
DRAK1 |
0.789 | -0.076 | 1 | 0.795 |
MARK4 |
0.789 | -0.004 | 4 | 0.812 |
ROCK1 |
0.789 | -0.017 | -3 | 0.731 |
SRPK3 |
0.789 | 0.090 | -3 | 0.722 |
PKN2 |
0.789 | -0.039 | -3 | 0.813 |
GSK3B |
0.788 | 0.021 | 4 | 0.475 |
CAMK2D |
0.788 | -0.022 | -3 | 0.825 |
CRIK |
0.788 | 0.025 | -3 | 0.706 |
IKKE |
0.788 | 0.063 | 1 | 0.752 |
P70S6KB |
0.788 | -0.007 | -3 | 0.776 |
SMG1 |
0.788 | -0.008 | 1 | 0.710 |
GSK3A |
0.788 | 0.044 | 4 | 0.482 |
CHK1 |
0.787 | -0.056 | -3 | 0.796 |
TSSK1 |
0.787 | -0.017 | -3 | 0.857 |
IKKB |
0.787 | 0.067 | -2 | 0.827 |
HIPK2 |
0.787 | 0.098 | 1 | 0.544 |
PLK3 |
0.786 | -0.106 | 2 | 0.538 |
HUNK |
0.785 | -0.149 | 2 | 0.563 |
RIPK3 |
0.785 | -0.141 | 3 | 0.651 |
AMPKA2 |
0.785 | 0.037 | -3 | 0.803 |
PKCA |
0.785 | 0.010 | 2 | 0.522 |
IKKA |
0.785 | 0.105 | -2 | 0.823 |
CDK13 |
0.785 | 0.028 | 1 | 0.593 |
SGK3 |
0.785 | 0.009 | -3 | 0.752 |
MRCKB |
0.785 | 0.004 | -3 | 0.715 |
DYRK1A |
0.785 | 0.017 | 1 | 0.662 |
CDK6 |
0.784 | 0.002 | 1 | 0.571 |
PRKD1 |
0.784 | 0.159 | -3 | 0.834 |
AKT2 |
0.784 | 0.041 | -3 | 0.683 |
DCAMKL2 |
0.783 | -0.083 | -3 | 0.786 |
MRCKA |
0.783 | -0.011 | -3 | 0.732 |
CLK4 |
0.783 | 0.042 | -3 | 0.755 |
CDK3 |
0.783 | 0.031 | 1 | 0.533 |
CDK14 |
0.782 | -0.007 | 1 | 0.601 |
CDK18 |
0.782 | 0.050 | 1 | 0.555 |
CDK12 |
0.781 | 0.024 | 1 | 0.569 |
PKCZ |
0.781 | -0.043 | 2 | 0.563 |
CDK4 |
0.781 | -0.004 | 1 | 0.557 |
RSK2 |
0.781 | 0.040 | -3 | 0.771 |
IRE1 |
0.781 | -0.094 | 1 | 0.704 |
ATM |
0.780 | -0.052 | 1 | 0.707 |
CAMK2B |
0.780 | -0.019 | 2 | 0.568 |
TTBK2 |
0.780 | -0.141 | 2 | 0.502 |
PAK1 |
0.779 | -0.021 | -2 | 0.796 |
PKCB |
0.779 | -0.020 | 2 | 0.520 |
P90RSK |
0.778 | 0.013 | -3 | 0.777 |
CDK7 |
0.778 | 0.039 | 1 | 0.618 |
CDK17 |
0.778 | 0.008 | 1 | 0.514 |
DYRK1B |
0.777 | 0.010 | 1 | 0.592 |
CDK8 |
0.777 | 0.007 | 1 | 0.602 |
MAPKAPK3 |
0.777 | 0.027 | -3 | 0.769 |
PLK2 |
0.777 | -0.062 | -3 | 0.737 |
CDK2 |
0.777 | -0.059 | 1 | 0.682 |
CLK2 |
0.776 | 0.125 | -3 | 0.743 |
PLK4 |
0.776 | -0.067 | 2 | 0.420 |
GRK4 |
0.776 | -0.098 | -2 | 0.880 |
SGK1 |
0.775 | 0.028 | -3 | 0.611 |
CDK16 |
0.775 | 0.009 | 1 | 0.528 |
IRE2 |
0.775 | -0.119 | 2 | 0.509 |
PAK2 |
0.775 | -0.081 | -2 | 0.786 |
CAMK2A |
0.775 | -0.010 | 2 | 0.580 |
PDHK3_TYR |
0.775 | 0.212 | 4 | 0.876 |
PKCH |
0.774 | -0.083 | 2 | 0.493 |
MYLK4 |
0.774 | -0.046 | -2 | 0.781 |
MELK |
0.774 | -0.072 | -3 | 0.786 |
QSK |
0.773 | 0.031 | 4 | 0.786 |
WNK3 |
0.773 | -0.258 | 1 | 0.763 |
AURB |
0.773 | 0.029 | -2 | 0.645 |
CDK9 |
0.773 | -0.015 | 1 | 0.600 |
DYRK3 |
0.773 | 0.003 | 1 | 0.638 |
NDR1 |
0.773 | -0.035 | -3 | 0.820 |
CLK1 |
0.773 | 0.053 | -3 | 0.729 |
DYRK4 |
0.773 | 0.010 | 1 | 0.565 |
AURC |
0.773 | 0.105 | -2 | 0.642 |
PAK3 |
0.772 | -0.051 | -2 | 0.797 |
PKCG |
0.772 | -0.038 | 2 | 0.515 |
AKT1 |
0.772 | 0.021 | -3 | 0.700 |
CHK2 |
0.771 | -0.012 | -3 | 0.628 |
PRKD2 |
0.771 | 0.115 | -3 | 0.769 |
STK33 |
0.771 | -0.139 | 2 | 0.435 |
PRKD3 |
0.771 | 0.018 | -3 | 0.734 |
NIM1 |
0.770 | -0.075 | 3 | 0.712 |
CDK10 |
0.770 | 0.021 | 1 | 0.583 |
RSK4 |
0.770 | 0.033 | -3 | 0.744 |
IRAK1 |
0.770 | -0.273 | -1 | 0.785 |
ULK1 |
0.769 | -0.157 | -3 | 0.787 |
MARK2 |
0.769 | -0.045 | 4 | 0.710 |
RSK3 |
0.769 | 0.020 | -3 | 0.758 |
AURA |
0.769 | 0.023 | -2 | 0.619 |
SSTK |
0.769 | -0.070 | 4 | 0.772 |
GCN2 |
0.768 | -0.131 | 2 | 0.574 |
SRPK2 |
0.768 | 0.104 | -3 | 0.678 |
PKCE |
0.767 | -0.029 | 2 | 0.509 |
MAPKAPK2 |
0.767 | 0.061 | -3 | 0.729 |
BCKDK |
0.767 | -0.069 | -1 | 0.826 |
PKACG |
0.767 | 0.002 | -2 | 0.738 |
QIK |
0.767 | -0.109 | -3 | 0.810 |
NDR2 |
0.767 | 0.036 | -3 | 0.836 |
CAMK4 |
0.767 | -0.142 | -3 | 0.790 |
MARK3 |
0.767 | -0.009 | 4 | 0.743 |
MSK1 |
0.766 | 0.002 | -3 | 0.742 |
GRK3 |
0.766 | -0.013 | -2 | 0.726 |
PKCI |
0.766 | -0.063 | 2 | 0.531 |
MAP2K4_TYR |
0.766 | 0.110 | -1 | 0.908 |
CDK19 |
0.766 | 0.021 | 1 | 0.566 |
PKG2 |
0.766 | 0.012 | -2 | 0.658 |
CK1D |
0.766 | 0.029 | -3 | 0.529 |
MNK2 |
0.765 | -0.004 | -2 | 0.804 |
PKACB |
0.765 | 0.065 | -2 | 0.664 |
LATS2 |
0.765 | -0.013 | -5 | 0.729 |
PDHK4_TYR |
0.764 | 0.052 | 2 | 0.659 |
PKCT |
0.764 | -0.063 | 2 | 0.507 |
CAMK1D |
0.763 | -0.060 | -3 | 0.672 |
MARK1 |
0.763 | -0.073 | 4 | 0.759 |
MAP2K6_TYR |
0.763 | 0.019 | -1 | 0.907 |
TESK1_TYR |
0.763 | 0.013 | 3 | 0.832 |
YANK3 |
0.762 | -0.063 | 2 | 0.292 |
MNK1 |
0.762 | -0.038 | -2 | 0.811 |
RIPK2 |
0.762 | -0.281 | 1 | 0.701 |
CK2A2 |
0.761 | 0.026 | 1 | 0.751 |
MSK2 |
0.761 | -0.037 | -3 | 0.747 |
BMPR2_TYR |
0.760 | 0.004 | -1 | 0.888 |
PDHK1_TYR |
0.760 | -0.001 | -1 | 0.913 |
LIMK2_TYR |
0.760 | 0.091 | -3 | 0.873 |
PHKG1 |
0.760 | -0.047 | -3 | 0.811 |
PKMYT1_TYR |
0.759 | 0.001 | 3 | 0.791 |
SBK |
0.758 | 0.002 | -3 | 0.570 |
FAM20C |
0.758 | 0.012 | 2 | 0.458 |
KIS |
0.757 | 0.108 | 1 | 0.628 |
SIK |
0.756 | -0.010 | -3 | 0.738 |
MAP2K7_TYR |
0.756 | -0.169 | 2 | 0.630 |
P70S6K |
0.756 | -0.033 | -3 | 0.691 |
CK1A2 |
0.755 | 0.002 | -3 | 0.527 |
NUAK1 |
0.755 | -0.054 | -3 | 0.762 |
TXK |
0.755 | 0.085 | 1 | 0.834 |
AKT3 |
0.754 | 0.032 | -3 | 0.634 |
CAMK1G |
0.754 | -0.120 | -3 | 0.740 |
ABL2 |
0.754 | 0.058 | -1 | 0.840 |
CK2A1 |
0.753 | 0.013 | 1 | 0.739 |
CK1E |
0.752 | 0.002 | -3 | 0.577 |
TTBK1 |
0.752 | -0.165 | 2 | 0.433 |
EPHB4 |
0.751 | -0.017 | -1 | 0.849 |
PINK1_TYR |
0.751 | -0.194 | 1 | 0.784 |
EPHA6 |
0.751 | -0.036 | -1 | 0.869 |
BRSK1 |
0.751 | -0.040 | -3 | 0.772 |
PAK6 |
0.750 | 0.011 | -2 | 0.721 |
YANK2 |
0.750 | -0.083 | 2 | 0.298 |
ROS1 |
0.750 | -0.019 | 3 | 0.708 |
RET |
0.750 | -0.068 | 1 | 0.754 |
TYK2 |
0.749 | -0.039 | 1 | 0.754 |
ABL1 |
0.749 | 0.027 | -1 | 0.834 |
PKACA |
0.749 | 0.028 | -2 | 0.601 |
BRSK2 |
0.749 | -0.083 | -3 | 0.792 |
FGR |
0.749 | -0.024 | 1 | 0.816 |
JAK2 |
0.748 | -0.024 | 1 | 0.749 |
LCK |
0.747 | 0.065 | -1 | 0.848 |
CSF1R |
0.747 | -0.053 | 3 | 0.720 |
TYRO3 |
0.747 | -0.098 | 3 | 0.739 |
MST1R |
0.747 | -0.083 | 3 | 0.744 |
CAMK1A |
0.747 | -0.058 | -3 | 0.642 |
JAK1 |
0.746 | 0.098 | 1 | 0.714 |
SNRK |
0.746 | -0.204 | 2 | 0.468 |
PKN1 |
0.745 | -0.059 | -3 | 0.711 |
LIMK1_TYR |
0.745 | -0.158 | 2 | 0.632 |
NEK10_TYR |
0.745 | 0.059 | 1 | 0.657 |
FER |
0.744 | -0.084 | 1 | 0.835 |
HCK |
0.744 | -0.020 | -1 | 0.848 |
ITK |
0.744 | -0.030 | -1 | 0.821 |
TNK2 |
0.743 | 0.007 | 3 | 0.685 |
BLK |
0.743 | 0.047 | -1 | 0.851 |
SRMS |
0.743 | -0.055 | 1 | 0.835 |
PRKX |
0.743 | 0.078 | -3 | 0.673 |
MAPKAPK5 |
0.743 | -0.090 | -3 | 0.712 |
EPHA4 |
0.742 | -0.074 | 2 | 0.552 |
YES1 |
0.742 | -0.078 | -1 | 0.864 |
JAK3 |
0.741 | -0.099 | 1 | 0.733 |
TNNI3K_TYR |
0.740 | -0.002 | 1 | 0.721 |
EPHB1 |
0.739 | -0.071 | 1 | 0.822 |
INSRR |
0.739 | -0.100 | 3 | 0.667 |
BMX |
0.738 | -0.017 | -1 | 0.747 |
MERTK |
0.738 | -0.055 | 3 | 0.690 |
EPHB3 |
0.738 | -0.079 | -1 | 0.832 |
EPHB2 |
0.738 | -0.066 | -1 | 0.828 |
KIT |
0.737 | -0.103 | 3 | 0.720 |
DDR1 |
0.736 | -0.218 | 4 | 0.783 |
PHKG2 |
0.735 | -0.101 | -3 | 0.764 |
PDGFRB |
0.734 | -0.158 | 3 | 0.738 |
TNK1 |
0.734 | -0.071 | 3 | 0.718 |
FYN |
0.734 | -0.026 | -1 | 0.823 |
MET |
0.733 | -0.086 | 3 | 0.711 |
AXL |
0.733 | -0.113 | 3 | 0.692 |
PAK5 |
0.732 | -0.029 | -2 | 0.652 |
FLT3 |
0.731 | -0.158 | 3 | 0.737 |
TEC |
0.731 | -0.083 | -1 | 0.765 |
FGFR2 |
0.731 | -0.201 | 3 | 0.713 |
ALK |
0.730 | -0.093 | 3 | 0.645 |
KDR |
0.730 | -0.150 | 3 | 0.668 |
PTK2B |
0.730 | -0.040 | -1 | 0.808 |
EPHA7 |
0.730 | -0.089 | 2 | 0.546 |
PTK6 |
0.730 | -0.109 | -1 | 0.758 |
BTK |
0.730 | -0.148 | -1 | 0.792 |
WEE1_TYR |
0.728 | -0.103 | -1 | 0.783 |
FRK |
0.728 | -0.088 | -1 | 0.860 |
PDGFRA |
0.727 | -0.179 | 3 | 0.737 |
FGFR1 |
0.727 | -0.189 | 3 | 0.685 |
LTK |
0.727 | -0.127 | 3 | 0.661 |
TEK |
0.726 | -0.205 | 3 | 0.657 |
LYN |
0.726 | -0.083 | 3 | 0.637 |
EPHA3 |
0.726 | -0.144 | 2 | 0.525 |
CK1G1 |
0.726 | -0.004 | -3 | 0.563 |
NTRK1 |
0.725 | -0.179 | -1 | 0.839 |
ERBB2 |
0.725 | -0.153 | 1 | 0.749 |
NTRK3 |
0.724 | -0.102 | -1 | 0.794 |
PTK2 |
0.724 | -0.021 | -1 | 0.777 |
EPHA1 |
0.723 | -0.130 | 3 | 0.691 |
INSR |
0.722 | -0.150 | 3 | 0.648 |
FLT1 |
0.722 | -0.170 | -1 | 0.841 |
SRC |
0.722 | -0.084 | -1 | 0.823 |
SYK |
0.722 | -0.019 | -1 | 0.781 |
EGFR |
0.722 | -0.089 | 1 | 0.664 |
PAK4 |
0.722 | -0.031 | -2 | 0.652 |
EPHA5 |
0.722 | -0.116 | 2 | 0.524 |
EPHA8 |
0.721 | -0.094 | -1 | 0.811 |
MATK |
0.721 | -0.111 | -1 | 0.768 |
FGFR3 |
0.720 | -0.202 | 3 | 0.675 |
NTRK2 |
0.719 | -0.203 | 3 | 0.662 |
CSK |
0.717 | -0.148 | 2 | 0.549 |
FGFR4 |
0.716 | -0.113 | -1 | 0.790 |
CK1G3 |
0.715 | -0.021 | -3 | 0.393 |
DDR2 |
0.715 | -0.125 | 3 | 0.650 |
FLT4 |
0.714 | -0.248 | 3 | 0.659 |
PKG1 |
0.712 | -0.048 | -2 | 0.564 |
EPHA2 |
0.712 | -0.108 | -1 | 0.776 |
MUSK |
0.710 | -0.117 | 1 | 0.654 |
ERBB4 |
0.708 | -0.080 | 1 | 0.703 |
IGF1R |
0.707 | -0.156 | 3 | 0.577 |
ZAP70 |
0.706 | -0.015 | -1 | 0.712 |
CK1A |
0.703 | 0.024 | -3 | 0.441 |
FES |
0.698 | -0.119 | -1 | 0.727 |
CK1G2 |
0.694 | -0.039 | -3 | 0.481 |