Motif 1005 (n=203)
Position-wise Probabilities
Download
| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0AVT1 | UBA6 | T938 | ochoa | Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (EC 6.2.1.45) (Monocyte protein 4) (MOP-4) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2) | Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:35970836, PubMed:35986001). Specific for ubiquitin, does not activate ubiquitin-like peptides. Also activates UBD/FAT10 conjugation via adenylation of its C-terminal glycine (PubMed:17889673, PubMed:35970836, PubMed:35986001). Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility. {ECO:0000269|PubMed:15202508, ECO:0000269|PubMed:17597759, ECO:0000269|PubMed:17889673, ECO:0000269|PubMed:35970836, ECO:0000269|PubMed:35986001}. |
| A7KAX9 | ARHGAP32 | T2060 | ochoa | Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) | GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}. |
| A8MSY1 | STIMATE-MUSTN1 | T353 | ochoa | Musculoskeletal embryonic nuclear protein 1 | None |
| A8MVX0 | ARHGEF33 | T681 | ochoa | Rho guanine nucleotide exchange factor 33 | May act as a guanine-nucleotide releasing factor. {ECO:0000250}. |
| O00151 | PDLIM1 | T141 | ochoa | PDZ and LIM domain protein 1 (C-terminal LIM domain protein 1) (Elfin) (LIM domain protein CLP-36) | Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (PubMed:10861853). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity). {ECO:0000250|UniProtKB:P52944, ECO:0000269|PubMed:10861853}. |
| O00267 | SUPT5H | T655 | ochoa | Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) | Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (PubMed:10075709, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed:10075709, PubMed:10199401, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed:16214896). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed:16214896). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (PubMed:16214896). Following phosphorylation by CDK9, DSIF can also positively regulate transcriptional elongation (PubMed:16427012). Required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat (PubMed:10393184, PubMed:10454543, PubMed:11809800, PubMed:9514752). DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences (PubMed:11112772, PubMed:14701750). {ECO:0000269|PubMed:10075709, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10421630, ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11553615, ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:12653964, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:14701750, ECO:0000269|PubMed:15136722, ECO:0000269|PubMed:15380072, ECO:0000269|PubMed:16214896, ECO:0000269|PubMed:16427012, ECO:0000269|PubMed:9450929, ECO:0000269|PubMed:9514752, ECO:0000269|PubMed:9857195}. |
| O00425 | IGF2BP3 | T528 | ochoa | Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2 mRNA-binding protein 3) (IMP-3) (IGF-II mRNA-binding protein 3) (KH domain-containing protein overexpressed in cancer) (hKOC) (VICKZ family member 3) | RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed:29476152). Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (PubMed:29476152). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. {ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:23640942, ECO:0000269|PubMed:29476152}. |
| O00512 | BCL9 | T172 | psp | B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog) | Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11955446}. |
| O14686 | KMT2D | T4688 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14744 | PRMT5 | T144 | psp | Protein arginine N-methyltransferase 5 (PRMT5) (EC 2.1.1.320) (72 kDa ICln-binding protein) (Histone-arginine N-methyltransferase PRMT5) (Jak-binding protein 1) (Shk1 kinase-binding protein 1 homolog) (SKB1 homolog) (SKB1Hs) [Cleaved into: Protein arginine N-methyltransferase 5, N-terminally processed] | Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, PubMed:12411503, PubMed:15737618, PubMed:17709427, PubMed:20159986, PubMed:20810653, PubMed:21081503, PubMed:21258366, PubMed:21917714, PubMed:22269951). Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles (PubMed:11747828, PubMed:12411503, PubMed:17709427). Methylates SUPT5H and may regulate its transcriptional elongation properties (PubMed:12718890). May methylate the N-terminal region of MBD2 (PubMed:16428440). Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. Methylates histone H2A and H4 'Arg-3' during germ cell development (By similarity). Methylates histone H3 'Arg-8', which may repress transcription (By similarity). Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (By similarity). Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation (PubMed:21258366, PubMed:21917714). Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity (PubMed:21917714). Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9 (PubMed:22269951). Methylates and regulates SRGAP2 which is involved in cell migration and differentiation (PubMed:20810653). Acts as a transcriptional corepressor in CRY1-mediated repression of the core circadian component PER1 by regulating the H4R3 dimethylation at the PER1 promoter (By similarity). Methylates GM130/GOLGA2, regulating Golgi ribbon formation (PubMed:20421892). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789). Symmetrically methylates POLR2A, a modification that allows the recruitment to POLR2A of proteins including SMN1/SMN2 and SETX. This is required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination (PubMed:26700805). Along with LYAR, binds the promoter of gamma-globin HBG1/HBG2 and represses its expression (PubMed:25092918). Symmetrically methylates NCL (PubMed:21081503). Methylates p53/TP53; methylation might possibly affect p53/TP53 target gene specificity (PubMed:19011621). Involved in spliceosome maturation and mRNA splicing in prophase I spermatocytes through the catalysis of the symmetrical arginine dimethylation of SNRPB (small nuclear ribonucleoprotein-associated protein) and the interaction with tudor domain-containing protein TDRD6 (By similarity). {ECO:0000250|UniProtKB:Q8CIG8, ECO:0000269|PubMed:10531356, ECO:0000269|PubMed:11152681, ECO:0000269|PubMed:11747828, ECO:0000269|PubMed:12411503, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17709427, ECO:0000269|PubMed:19011621, ECO:0000269|PubMed:20159986, ECO:0000269|PubMed:20421892, ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21081503, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:21917714, ECO:0000269|PubMed:22269951, ECO:0000269|PubMed:25092918, ECO:0000269|PubMed:25284789, ECO:0000269|PubMed:26700805}. |
| O15047 | SETD1A | T475 | ochoa | Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.364) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:12670868, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:29937342, PubMed:31197650, PubMed:32346159). Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis (By similarity) (PubMed:31197650). Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation (PubMed:29937342, PubMed:32346159). Does not methylate 'Lys-4' of histone H3 if the neighboring 'Lys-9' residue is already methylated (PubMed:12670868). Binds RNAs involved in RNA processing and the DNA damage response (PubMed:38003223). {ECO:0000250|UniProtKB:E9PYH6, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:25561738, ECO:0000269|PubMed:29937342, ECO:0000269|PubMed:31197650, ECO:0000269|PubMed:32346159, ECO:0000269|PubMed:38003223}. |
| O43159 | RRP8 | T220 | ochoa | Ribosomal RNA-processing protein 8 (EC 2.1.1.-) (Cerebral protein 1) (Nucleomethylin) | Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown. {ECO:0000269|PubMed:18485871}. |
| O43257 | ZNHIT1 | T103 | psp | Zinc finger HIT domain-containing protein 1 (Cyclin-G1-binding protein 1) (Zinc finger protein subfamily 4A member 1) (p18 Hamlet) | Plays a role in chromatin remodeling by promoting the incorporation of histone variant H2AZ1/H2A.Z into the genome to regulate gene expression (PubMed:20473270, PubMed:35175558). Promotes SRCAP complex-mediated deposition of histone variant H2AZ1 to lymphoid fate regulator genes, enhancing lymphoid lineage commitment (By similarity). Recruited to the promoter of the transcriptional activator MYOG at the early stages of muscle differentiation where it mediates binding of histone H2AZ1 to chromatin and induces muscle-specific gene expression (PubMed:20473270). Maintains hematopoietic stem cell (HSC) quiescence by determining the chromatin accessibility at distal enhancers of HSC quiescence genes such as PTEN, FSTL1 and KLF4, enhancing deposition of H2AZ1 to promote their sustained transcription and restricting PI3K-AKT signaling inhibition (By similarity). Plays a role in intestinal stem cell maintenance by promoting H2AZ1 deposition at the transcription start sites of genes involved in intestinal stem cell fate determination including LGR5, TGFB1 and TGFBR2, thereby contributing to gene transcription (By similarity). Promotes phosphorylation of the H2AZ1 chaperone VPS72/YL1 which enhances the interaction between HZAZ1 and VPS72 (By similarity). Regulates the entry of male germ cells into meiosis by controlling histone H2AZ1 deposition which facilitates the expression of meiotic genes such as MEIOSIN, leading to the initiation of meiosis (By similarity). Required for postnatal heart function through its role in maintenance of cardiac Ca(2+) homeostasis by modulating the expression of Ca(2+)-regulating proteins CASQ1 and ATP2A2/SERCA2A via deposition of histone H2AZ1 at their promoters (By similarity). During embryonic heart development, required for mitochondrial maturation and oxidative metabolism by functioning through H2AZ1 deposition to activate transcription of metabolic genes and is also required to maintain the stability of the respiratory complex (By similarity). In neural cells, increases deposition of the H2AZ1 histone variant and promotes neurite growth (PubMed:35175558). Plays a role in TP53/p53-mediated apoptosis induction by stimulating the transcriptional activation of several proapoptotic p53 target genes such as PMAIP1/NOXA and BBC3/PUMA (PubMed:17380123). Mediates cell cycle arrest induced in response to gamma-irradiation by enhancing recruitment of TP53/p53 to the promoter of the cell cycle inhibitor CDKN1A, leading to its transcriptional activation (PubMed:17700068). Recruited to the promoter of cyclin-dependent kinase CDK6 and inhibits its transcription, possibly by decreasing the acetylation level of histone H4, leading to cell cycle arrest at the G1 phase (By similarity). Plays a role in lens fiber cell differentiation by regulating the expression of cell cycle regulator CDKN1A/p21Cip1 (By similarity). Binds to transcriptional repressor NR1D2 and relieves it of its inhibitory effect on the transcription of apolipoprotein APOC3 without affecting its DNA-binding activity (PubMed:17892483). {ECO:0000250|UniProtKB:Q8R331, ECO:0000269|PubMed:17380123, ECO:0000269|PubMed:17700068, ECO:0000269|PubMed:17892483, ECO:0000269|PubMed:20473270, ECO:0000269|PubMed:35175558}. |
| O43312 | MTSS1 | T588 | ochoa | Protein MTSS 1 (Metastasis suppressor YGL-1) (Metastasis suppressor protein 1) (Missing in metastasis protein) | May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton. |
| O43561 | LAT | T184 | ochoa | Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38) | Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development (PubMed:23514740, PubMed:25907557). Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:10072481, ECO:0000269|PubMed:23514740, ECO:0000269|PubMed:25907557}. |
| O43639 | NCK2 | T95 | ochoa | Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta) | Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16835242}. |
| O60741 | HCN1 | T646 | psp | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) | Hyperpolarization-activated ion channel that are permeable to sodium and potassium ions (PubMed:15351778, PubMed:28086084). Displays lower selectivity for K(+) over Na(+) ions (PubMed:28086084). Contributes to the native pacemaker currents in heart (If) and in the generation of the I(h) current which controls neuron excitability (PubMed:29936235, PubMed:30351409). Participates in cerebellar mechanisms of motor learning (By similarity). May mediate responses to sour stimuli (By similarity). {ECO:0000250|UniProtKB:O88704, ECO:0000269|PubMed:15351778, ECO:0000269|PubMed:28086084, ECO:0000269|PubMed:29936235, ECO:0000269|PubMed:30351409}. |
| O60907 | TBL1X | T383 | psp | F-box-like/WD repeat-containing protein TBL1X (SMAP55) (Transducin beta-like protein 1X) (Transducin-beta-like protein 1, X-linked) | F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units (PubMed:14980219). Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (PubMed:21240272). {ECO:0000269|PubMed:14980219, ECO:0000269|PubMed:21240272}. |
| O60941 | DTNB | T551 | ochoa | Dystrobrevin beta (DTN-B) (Beta-dystrobrevin) | Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids (By similarity). May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation (PubMed:27223470). May be required for proper maturation and function of a subset of inhibitory synapses (By similarity). {ECO:0000250|UniProtKB:O70585, ECO:0000269|PubMed:27223470}. |
| O75150 | RNF40 | T574 | ochoa | E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B) | Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. {ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:19410543}.; FUNCTION: (Microbial infection) Promotes the human herpesvirus 8 (KSHV) lytic cycle by inducing the expression of lytic viral genes including the latency switch gene RTA/ORF50. {ECO:0000269|PubMed:37888983}. |
| O75369 | FLNB | T1400 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75694 | NUP155 | T737 | ochoa | Nuclear pore complex protein Nup155 (155 kDa nucleoporin) (Nucleoporin Nup155) | Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. {ECO:0000250|UniProtKB:Q99P88}. |
| O75717 | WDHD1 | T310 | ochoa | WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA-binding protein 1) (And-1) | Core replisome component that acts as a replication initiation factor. Binds directly to the CMG complex and functions as a hub to recruit additional proteins to the replication fork. {ECO:0000269|PubMed:19805216, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
| O95870 | ABHD16A | T34 | ochoa | Phosphatidylserine lipase ABHD16A (EC 3.1.-.-) (Alpha/beta hydrolase domain-containing protein 16A) (Abhydrolase domain-containing protein 16A) (HLA-B-associated transcript 5) (hBAT5) (Monoacylglycerol lipase ABHD16A) (EC 3.1.1.23) (Protein G5) | Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS) (By similarity). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By similarity). Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase (PubMed:25290914). Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z-octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ(2)-G) (PubMed:25290914). {ECO:0000250|UniProtKB:Q9Z1Q2, ECO:0000269|PubMed:25290914}. |
| P00387 | CYB5R3 | T171 | ochoa | NADH-cytochrome b5 reductase 3 (B5R) (Cytochrome b5 reductase) (EC 1.6.2.2) (Diaphorase-1) | Catalyzes the reduction of two molecules of cytochrome b5 using NADH as the electron donor. {ECO:0000269|PubMed:10807796, ECO:0000269|PubMed:1400360, ECO:0000269|PubMed:15953014, ECO:0000269|PubMed:1898726, ECO:0000269|PubMed:2019583, ECO:0000269|PubMed:8119939, ECO:0000269|PubMed:9639531}. |
| P00519 | ABL1 | T1008 | ochoa | Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) | Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 also acts as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:22810897, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}. |
| P02671 | FGA | T412 | ochoa | Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain] | Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}. |
| P04626 | ERBB2 | T1172 | psp | Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340) | Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:15380516, ECO:0000269|PubMed:21555369}. |
| P05091 | ALDH2 | T202 | psp | Aldehyde dehydrogenase, mitochondrial (EC 1.2.1.3) (ALDH class 2) (ALDH-E2) (ALDHI) | Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage. {ECO:0000269|PubMed:33355142}. |
| P07203 | GPX1 | T151 | ochoa | Glutathione peroxidase 1 (GPx-1) (GSHPx-1) (EC 1.11.1.9) (Cellular glutathione peroxidase) (Phospholipid-hydroperoxide glutathione peroxidase GPX1) (EC 1.11.1.12) | Catalyzes the reduction of hydroperoxides in a glutathione-dependent manner thus regulating cellular redox homeostasis (PubMed:11115402, PubMed:36608588). Can reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide, as well as several fatty acid-derived hydroperoxides (PubMed:11115402, PubMed:36608588). In platelets catalyzes the reduction of 12-hydroperoxyeicosatetraenoic acid, the primary product of the arachidonate 12-lipoxygenase pathway (PubMed:11115402). {ECO:0000269|PubMed:11115402, ECO:0000269|PubMed:36608588}. |
| P07237 | P4HB | T187 | ochoa | Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55) | This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations and following phosphorylation by FAM20C, functions as a chaperone that inhibits aggregation of misfolded proteins (PubMed:32149426). At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts as a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307). {ECO:0000269|PubMed:10636893, ECO:0000269|PubMed:12485997, ECO:0000269|PubMed:21670307, ECO:0000269|PubMed:32149426}. |
| P08172 | CHRM2 | T423 | psp | Muscarinic acetylcholine receptor M2 | The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. {ECO:0000269|PubMed:24256733, ECO:0000269|PubMed:3443095}. |
| P09884 | POLA1 | T1268 | ochoa | DNA polymerase alpha catalytic subunit (EC 2.7.7.7) (DNA polymerase alpha catalytic subunit p180) | Catalytic subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, a regulatory subunit POLA2 and two primase subunits PRIM1 and PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. The reason this transfer occurs is because the polymerase alpha has limited processivity and lacks intrinsic 3' exonuclease activity for proofreading error, and therefore is not well suited for replicating long complexes. In the cytosol, responsible for a substantial proportion of the physiological concentration of cytosolic RNA:DNA hybrids, which are necessary to prevent spontaneous activation of type I interferon responses (PubMed:27019227). {ECO:0000269|PubMed:26975377, ECO:0000269|PubMed:27019227, ECO:0000269|PubMed:31006512, ECO:0000269|PubMed:9518481}. |
| P0C7T5 | ATXN1L | T333 | ochoa | Ataxin-1-like (Brother of ataxin-1) (Brother of ATXN1) | Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (PubMed:21475249). Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development (By similarity). {ECO:0000250|UniProtKB:P0C7T6, ECO:0000269|PubMed:21475249}. |
| P10746 | UROS | T242 | ochoa | Uroporphyrinogen-III synthase (UROIIIS) (UROS) (EC 4.2.1.75) (Hydroxymethylbilane hydrolyase [cyclizing]) (Uroporphyrinogen-III cosynthase) | Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins (PubMed:11689424, PubMed:18004775). Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme) (PubMed:11689424, PubMed:18004775). {ECO:0000269|PubMed:11689424, ECO:0000269|PubMed:18004775}. |
| P14618 | PKM | T121 | ochoa | Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) | Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:1854723, ECO:0000269|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250|UniProtKB:P52480, ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263}. |
| P16150 | SPN | T316 | ochoa | Leukosialin (GPL115) (Galactoglycoprotein) (GALGP) (Leukocyte sialoglycoprotein) (Sialophorin) (CD antigen CD43) [Cleaved into: CD43 cytoplasmic tail (CD43-ct) (CD43ct)] | Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN) (By similarity). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells (PubMed:18036228). Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR (PubMed:24328034). Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E-selectin. Acts as a T-cell counter-receptor for SIGLEC1 (By similarity). {ECO:0000250|UniProtKB:P15702, ECO:0000269|PubMed:18036228, ECO:0000269|PubMed:24328034}.; FUNCTION: [CD43 cytoplasmic tail]: Protects cells from apoptotic signals, promoting cell survival. {ECO:0000250|UniProtKB:P15702}. |
| P19338 | NCL | T325 | ochoa | Nucleolin (Protein C23) | Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269|PubMed:10393184}. |
| P19878 | NCF2 | T233 | ochoa|psp | Neutrophil cytosol factor 2 (NCF-2) (67 kDa neutrophil oxidase factor) (NADPH oxidase activator 2) (Neutrophil NADPH oxidase factor 2) (p67-phox) | Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:12207919, PubMed:38355798). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (PubMed:38355798). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (PubMed:38355798). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (By similarity). {ECO:0000250|UniProtKB:P14598, ECO:0000269|PubMed:12207919, ECO:0000269|PubMed:38355798}. |
| P20138 | CD33 | T302 | ochoa | Myeloid cell surface antigen CD33 (Sialic acid-binding Ig-like lectin 3) (Siglec-3) (gp67) (CD antigen CD33) | Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (PubMed:10611343, PubMed:11320212, PubMed:15597323). Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans (PubMed:7718872). Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK (PubMed:10887109, PubMed:28325905). These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:10206955, PubMed:10556798, PubMed:10887109). In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules (PubMed:10206955, PubMed:10887109). One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K (PubMed:15597323). {ECO:0000269|PubMed:10206955, ECO:0000269|PubMed:10556798, ECO:0000269|PubMed:10611343, ECO:0000269|PubMed:10887109, ECO:0000269|PubMed:11320212, ECO:0000269|PubMed:15597323, ECO:0000269|PubMed:28325905, ECO:0000269|PubMed:7718872}. |
| P20810 | CAST | T410 | ochoa | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| P22670 | RFX1 | T164 | ochoa | MHC class II regulatory factor RFX1 (Enhancer factor C) (EF-C) (Regulatory factor X 1) (RFX) (Transcription factor RFX1) | Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes. Also binds to an inverted repeat (ENH1) required for hepatitis B virus genes expression and to the most upstream element (alpha) of the RPL30 promoter. |
| P22736 | NR4A1 | T55 | psp | Nuclear receptor subfamily 4immunitygroup A member 1 (Early response protein NAK1) (Nuclear hormone receptor NUR/77) (Nur77) (Orphan nuclear receptor HMR) (Orphan nuclear receptor TR3) (ST-59) (Testicular receptor 3) | Orphan nuclear receptor. Binds the NGFI-B response element (NBRE) 5'-AAAGGTCA-3' (PubMed:18690216, PubMed:8121493, PubMed:9315652). Binds 9-cis-retinoic acid outside of its ligand-binding (NR LBD) domain (PubMed:18690216). Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (PubMed:22983157). Regulates the inflammatory response in macrophages by regulating metabolic adaptations during inflammation, including repressing the transcription of genes involved in the citric acid cycle (TCA) (By similarity). Inhibits NF-kappa-B signaling by binding to low-affinity NF-kappa-B binding sites, such as at the IL2 promoter (PubMed:15466594). May act concomitantly with NR4A2 in regulating the expression of delayed-early genes during liver regeneration (By similarity). Plays a role in the vascular response to injury (By similarity). {ECO:0000250|UniProtKB:P12813, ECO:0000250|UniProtKB:P22829, ECO:0000269|PubMed:15466594, ECO:0000269|PubMed:18690216, ECO:0000269|PubMed:22983157, ECO:0000269|PubMed:8121493, ECO:0000269|PubMed:9315652}.; FUNCTION: In the cytosol, upon its detection of both bacterial lipopolysaccharide (LPS) and NBRE-containing mitochondrial DNA released by GSDMD pores during pyroptosis, it promotes non-canonical NLRP3 inflammasome activation by stimulating association of NLRP3 and NEK7. {ECO:0000250|UniProtKB:P12813}. |
| P25942 | CD40 | T254 | psp | Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (Bp50) (CD40L receptor) (CDw40) (CD antigen CD40) | Receptor for TNFSF5/CD40LG (PubMed:31331973). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). {ECO:0000250|UniProtKB:P27512, ECO:0000269|PubMed:31331973}. |
| P27816 | MAP4 | T159 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P27816 | MAP4 | T582 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P29375 | KDM5A | T209 | ochoa | Lysine-specific demethylase 5A (EC 1.14.11.67) (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2) ([histone H3]-trimethyl-L-lysine(4) demethylase 5A) | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif (PubMed:18270511). May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (PubMed:19430464). May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity). Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells (PubMed:27427228). {ECO:0000250|UniProtKB:Q3UXZ9, ECO:0000269|PubMed:11358960, ECO:0000269|PubMed:15949438, ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17320163, ECO:0000269|PubMed:18270511, ECO:0000269|PubMed:19430464, ECO:0000269|PubMed:27427228}. |
| P30086 | PEBP1 | T42 | ochoa|psp | Phosphatidylethanolamine-binding protein 1 (PEBP-1) (HCNPpp) (Neuropolypeptide h3) (Prostatic-binding protein) (Raf kinase inhibitor protein) (RKIP) [Cleaved into: Hippocampal cholinergic neurostimulating peptide (HCNP)] | Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. {ECO:0000250, ECO:0000269|PubMed:18294816}.; FUNCTION: HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity). {ECO:0000250}. |
| P31939 | ATIC | T109 | ochoa | Bifunctional purine biosynthesis protein ATIC (AICAR transformylase/inosine monophosphate cyclohydrolase) (ATIC) [Cleaved into: Bifunctional purine biosynthesis protein ATIC, N-terminally processed] [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (IMP synthase) (Inosinicase)] | Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:11948179, PubMed:14756554). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:10985775, PubMed:11948179, PubMed:9378707). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction (PubMed:10985775). Also catalyzes the cyclization of FAICAR to inosine monophosphate (IMP) (PubMed:11948179, PubMed:14756554). Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias (PubMed:10985775). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). {ECO:0000269|PubMed:10985775, ECO:0000269|PubMed:11948179, ECO:0000269|PubMed:14756554, ECO:0000269|PubMed:25687571, ECO:0000269|PubMed:9378707}. |
| P35236 | PTPN7 | T66 | ochoa|psp | Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48) (Hematopoietic protein-tyrosine phosphatase) (HEPTP) (Protein-tyrosine phosphatase LC-PTP) | Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction. {ECO:0000269|PubMed:10206983, ECO:0000269|PubMed:10559944, ECO:0000269|PubMed:10702794, ECO:0000269|PubMed:1510684, ECO:0000269|PubMed:1530918, ECO:0000269|PubMed:9624114}. |
| P35236 | PTPN7 | T71 | ochoa | Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48) (Hematopoietic protein-tyrosine phosphatase) (HEPTP) (Protein-tyrosine phosphatase LC-PTP) | Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction. {ECO:0000269|PubMed:10206983, ECO:0000269|PubMed:10559944, ECO:0000269|PubMed:10702794, ECO:0000269|PubMed:1510684, ECO:0000269|PubMed:1530918, ECO:0000269|PubMed:9624114}. |
| P40200 | CD96 | T508 | ochoa | T-cell surface protein tactile (Cell surface antigen CD96) (T cell-activated increased late expression protein) (CD antigen CD96) | May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation. |
| P46937 | YAP1 | T145 | ochoa | Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) | Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signaling pathway, crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The Hippo signaling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Phosphorylation of YAP1 by LATS1/2 prevents its nuclear translocation, thereby regulating the expression of its target genes (PubMed:18158288, PubMed:26598551, PubMed:34404733). The transcriptional regulation of gene expression requires TEAD transcription factors and modulates cell growth, anchorage-independent growth, and induction of epithelial-mesenchymal transition (EMT) (PubMed:18579750). Plays a key role in tissue tension and 3D tissue shape by regulating the cortical actomyosin network, acting via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). It also suppresses ciliogenesis by acting as a transcriptional corepressor of TEAD4 target genes AURKA and PLK1 (PubMed:25849865). In conjunction with WWTR1, regulates TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). Synergizes with WBP2 to enhance PGR activity (PubMed:16772533). {ECO:0000250|UniProtKB:P46938, ECO:0000269|PubMed:16772533, ECO:0000269|PubMed:17974916, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:18280240, ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:21364637, ECO:0000269|PubMed:25778702, ECO:0000269|PubMed:25849865, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:30447097, ECO:0000269|PubMed:34404733}.; FUNCTION: [Isoform 2]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}.; FUNCTION: [Isoform 3]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}. |
| P49006 | MARCKSL1 | T85 | ochoa | MARCKS-related protein (MARCKS-like protein 1) (Macrophage myristoylated alanine-rich C kinase substrate) (Mac-MARCKS) (MacMARCKS) | Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation (PubMed:22751924). When unphosphorylated, induces cell migration (By similarity). When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration (By similarity). May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity). {ECO:0000250|UniProtKB:P28667, ECO:0000269|PubMed:22751924}. |
| P49757 | NUMB | T631 | ochoa | Protein numb homolog (h-Numb) (Protein S171) | Regulates clathrin-mediated receptor endocytosis (PubMed:18657069). Plays a role in the process of neurogenesis (By similarity). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity). May also mediate local repair of brain ventricular wall damage (By similarity). {ECO:0000250|UniProtKB:Q9QZS3, ECO:0000269|PubMed:18657069}. |
| P49790 | NUP153 | T638 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P50990 | CCT8 | T293 | psp | T-complex protein 1 subunit theta (TCP-1-theta) (EC 3.6.1.-) (CCT-theta) (Chaperonin containing T-complex polypeptide 1 subunit 8) (Renal carcinoma antigen NY-REN-15) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P54296 | MYOM2 | T901 | ochoa | Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P55011 | SLC12A2 | T75 | ochoa | Solute carrier family 12 member 2 (Basolateral Na-K-Cl symporter) (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2) (BSC2) (Na-K-2Cl cotransporter 1) (hNKCC1) | Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:33597714, PubMed:35585053, PubMed:36239040, PubMed:36306358, PubMed:7629105). Plays a vital role in the regulation of ionic balance and cell volume (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:7629105). {ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:32294086, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0000269|PubMed:7629105}. |
| P55017 | SLC12A3 | T46 | psp | Solute carrier family 12 member 3 (Na-Cl cotransporter) (NCC) (Na-Cl symporter) (Thiazide-sensitive sodium-chloride cotransporter) | Electroneutral sodium and chloride ion cotransporter, which acts as a key mediator of sodium and chloride reabsorption in kidney distal convoluted tubules (PubMed:18270262, PubMed:21613606, PubMed:22009145, PubMed:36351028, PubMed:36792826). Also acts as a receptor for the pro-inflammatory cytokine IL18, thereby contributing to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2 (By similarity). May act either independently of IL18R1, or in a complex with IL18R1 (By similarity). {ECO:0000250|UniProtKB:P59158, ECO:0000269|PubMed:18270262, ECO:0000269|PubMed:21613606, ECO:0000269|PubMed:22009145, ECO:0000269|PubMed:36351028, ECO:0000269|PubMed:36792826}. |
| P57678 | GEMIN4 | T84 | ochoa | Gem-associated protein 4 (Gemin-4) (Component of gems 4) (p97) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. {ECO:0000269|PubMed:18984161}. |
| P60709 | ACTB | T106 | ochoa | Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P63261 | ACTG1 | T106 | ochoa | Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}. |
| P78527 | PRKDC | T2620 | ochoa|psp | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
| P78559 | MAP1A | T1084 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| Q00587 | CDC42EP1 | T372 | ochoa | Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55) | Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts. {ECO:0000269|PubMed:10430899}. |
| Q01581 | HMGCS1 | T476 | ochoa | Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase) | Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis. {ECO:0000269|PubMed:7913309}. |
| Q01826 | SATB1 | T466 | ochoa | DNA-binding protein SATB1 (Special AT-rich sequence-binding protein 1) | Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis. Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone, possibly by positively regulating the expression of NEUROD1 (By similarity). {ECO:0000250|UniProtKB:Q60611, ECO:0000269|PubMed:10595394, ECO:0000269|PubMed:11463840, ECO:0000269|PubMed:12374985, ECO:0000269|PubMed:12692553, ECO:0000269|PubMed:1505028, ECO:0000269|PubMed:15618465, ECO:0000269|PubMed:15713622, ECO:0000269|PubMed:16377216, ECO:0000269|PubMed:16630892, ECO:0000269|PubMed:17173041, ECO:0000269|PubMed:17376900, ECO:0000269|PubMed:18337816, ECO:0000269|PubMed:19103759, ECO:0000269|PubMed:19247486, ECO:0000269|PubMed:19332023, ECO:0000269|PubMed:19430959, ECO:0000269|PubMed:33513338, ECO:0000269|PubMed:9111059, ECO:0000269|PubMed:9548713}. |
| Q01844 | EWSR1 | T78 | ochoa | RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein) | Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Might normally function as a transcriptional repressor (PubMed:10767297). EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. {ECO:0000269|PubMed:10767297, ECO:0000269|PubMed:21256132}. |
| Q02952 | AKAP12 | T723 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q02952 | AKAP12 | T1724 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q03001 | DST | T7440 | ochoa | Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) | Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). {ECO:0000250|UniProtKB:Q91ZU6}.; FUNCTION: [Isoform 3]: Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.; FUNCTION: [Isoform 6]: Required for bundling actin filaments around the nucleus. {ECO:0000250, ECO:0000269|PubMed:10428034, ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692}.; FUNCTION: [Isoform 7]: Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. |
| Q03431 | PTH1R | T547 | psp | Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor) | G-protein-coupled receptor for parathyroid hormone (PTH) and for parathyroid hormone-related peptide (PTHLH) (PubMed:10913300, PubMed:18375760, PubMed:19674967, PubMed:27160269, PubMed:30975883, PubMed:35932760, PubMed:8397094). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP) (PubMed:30975883, PubMed:35932760). PTH1R is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (PubMed:20172855, PubMed:30975883, PubMed:35932760). PTHLH dissociates from PTH1R more rapidly than PTH; as consequence, the cAMP response induced by PTHLH decays faster than the response induced by PTH (PubMed:35932760). {ECO:0000269|PubMed:10913300, ECO:0000269|PubMed:18375760, ECO:0000269|PubMed:19674967, ECO:0000269|PubMed:20172855, ECO:0000269|PubMed:27160269, ECO:0000269|PubMed:30975883, ECO:0000269|PubMed:35932760, ECO:0000269|PubMed:8397094}. |
| Q03468 | ERCC6 | T303 | ochoa | DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB) | Essential factor involved in transcription-coupled nucleotide excision repair (TC-NER), a process during which RNA polymerase II-blocking lesions are rapidly removed from the transcribed strand of active genes (PubMed:16246722, PubMed:20541997, PubMed:22483866, PubMed:26620705, PubMed:32355176, PubMed:34526721, PubMed:38316879, PubMed:38600235, PubMed:38600236). Plays a central role in the initiation of the TC-NER process: specifically recognizes and binds RNA polymerase II stalled at a lesion, and mediates recruitment of ERCC8/CSA, initiating DNA damage excision by TFIIH recruitment (PubMed:32355176, PubMed:34526721, PubMed:38600235, PubMed:38600236). Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA (PubMed:15548521). Acts as a chromatin remodeler at DSBs; DNA-dependent ATPase-dependent activity is essential for this function (PubMed:16246722, PubMed:9565609). Plays an important role in regulating the choice of the DNA double-strand breaks (DSBs) repair pathway and G2/M checkpoint activation; DNA-dependent ATPase activity is essential for this function (PubMed:25820262). Regulates the DNA repair pathway choice by inhibiting non-homologous end joining (NHEJ), thereby promoting the homologous recombination (HR)-mediated repair of DSBs during the S/G2 phases of the cell cycle (PubMed:25820262). Mediates the activation of the ATM- and CHEK2-dependent DNA damage responses thus preventing premature entry of cells into mitosis following the induction of DNA DSBs (PubMed:25820262). Remodels chromatin by evicting histones from chromatin flanking DSBs, limiting RIF1 accumulation at DSBs thereby promoting BRCA1-mediated HR (PubMed:29203878). Required for stable recruitment of ELOA and CUL5 to DNA damage sites (PubMed:28292928). Also involved in UV-induced translocation of ERCC8 to the nuclear matrix (PubMed:26620705). Essential for neuronal differentiation and neuritogenesis; regulates transcription and chromatin remodeling activities required during neurogenesis (PubMed:24874740). {ECO:0000269|PubMed:15548521, ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:20541997, ECO:0000269|PubMed:22483866, ECO:0000269|PubMed:24874740, ECO:0000269|PubMed:25820262, ECO:0000269|PubMed:26620705, ECO:0000269|PubMed:28292928, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:32355176, ECO:0000269|PubMed:34526721, ECO:0000269|PubMed:38316879, ECO:0000269|PubMed:38600235, ECO:0000269|PubMed:38600236, ECO:0000269|PubMed:9565609}. |
| Q08211 | DHX9 | T92 | ochoa | ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (DExH-box helicase 9) (Leukophysin) (LKP) (Nuclear DNA helicase II) (NDH II) (RNA helicase A) | Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing (PubMed:11416126, PubMed:12711669, PubMed:15355351, PubMed:16680162, PubMed:17531811, PubMed:20669935, PubMed:21561811, PubMed:24049074, PubMed:24990949, PubMed:25062910, PubMed:28221134, PubMed:9111062, PubMed:37467750). Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs) (PubMed:1537828). Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA and RNA, DNA:RNA hybrids, DNA and RNA forks composed of either partially complementary DNA duplexes or DNA:RNA hybrids, respectively, and also DNA and RNA displacement loops (D- and R-loops), triplex-helical DNA (H-DNA) structure and DNA and RNA-based G-quadruplexes (PubMed:20669935, PubMed:21561811, PubMed:24049074). Binds dsDNA, single-stranded DNA (ssDNA), dsRNA, ssRNA and poly(A)-containing RNA (PubMed:10198287, PubMed:9111062). Also binds to circular dsDNA or dsRNA of either linear and/or circular forms and stimulates the relaxation of supercoiled DNAs catalyzed by topoisomerase TOP2A (PubMed:12711669). Plays a role in DNA replication at origins of replication and cell cycle progression (PubMed:24990949). Plays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors, such as BRCA1, CREBBP, RELA and SMN1 (PubMed:11038348, PubMed:11149922, PubMed:11416126, PubMed:15355351, PubMed:28221134, PubMed:9323138, PubMed:9662397). Binds to the CDKN2A promoter (PubMed:11038348). Plays several roles in post-transcriptional regulation of gene expression (PubMed:28221134, PubMed:28355180). In cooperation with NUP98, promotes pre-mRNA alternative splicing activities of a subset of genes (PubMed:11402034, PubMed:16680162, PubMed:28221134, PubMed:28355180). As component of a large PER complex, is involved in the negative regulation of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms (By similarity). Also acts as a nuclear resolvase that is able to bind and neutralize harmful massive secondary double-stranded RNA structures formed by inverted-repeat Alu retrotransposon elements that are inserted and transcribed as parts of genes during the process of gene transposition (PubMed:28355180). Involved in the positive regulation of nuclear export of constitutive transport element (CTE)-containing unspliced mRNA (PubMed:10924507, PubMed:11402034, PubMed:9162007). Component of the coding region determinant (CRD)-mediated complex that promotes cytoplasmic MYC mRNA stability (PubMed:19029303). Plays a role in mRNA translation (PubMed:28355180). Positively regulates translation of selected mRNAs through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Involved with LARP6 in the translation stimulation of type I collagen mRNAs for CO1A1 and CO1A2 through binding of a specific stem-loop structure in their 5'-UTRs (PubMed:22190748). Stimulates LIN28A-dependent mRNA translation probably by facilitating ribonucleoprotein remodeling during the process of translation (PubMed:21247876). Plays also a role as a small interfering (siRNA)-loading factor involved in the RNA-induced silencing complex (RISC) loading complex (RLC) assembly, and hence functions in the RISC-mediated gene silencing process (PubMed:17531811). Binds preferentially to short double-stranded RNA, such as those produced during rotavirus intestinal infection (PubMed:28636595). This interaction may mediate NLRP9 inflammasome activation and trigger inflammatory response, including IL18 release and pyroptosis (PubMed:28636595). Finally, mediates the attachment of heterogeneous nuclear ribonucleoproteins (hnRNPs) to actin filaments in the nucleus (PubMed:11687588). {ECO:0000250|UniProtKB:O70133, ECO:0000269|PubMed:10198287, ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:11038348, ECO:0000269|PubMed:11149922, ECO:0000269|PubMed:11402034, ECO:0000269|PubMed:11416126, ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:12711669, ECO:0000269|PubMed:15355351, ECO:0000269|PubMed:1537828, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:17531811, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:20669935, ECO:0000269|PubMed:21247876, ECO:0000269|PubMed:21561811, ECO:0000269|PubMed:22190748, ECO:0000269|PubMed:24049074, ECO:0000269|PubMed:24990949, ECO:0000269|PubMed:25062910, ECO:0000269|PubMed:28221134, ECO:0000269|PubMed:28355180, ECO:0000269|PubMed:28636595, ECO:0000269|PubMed:37467750, ECO:0000269|PubMed:9111062, ECO:0000269|PubMed:9162007, ECO:0000269|PubMed:9323138, ECO:0000269|PubMed:9662397}.; FUNCTION: (Microbial infection) Plays a role in HIV-1 replication and virion infectivity (PubMed:11096080, PubMed:19229320, PubMed:25149208, PubMed:27107641). Enhances HIV-1 transcription by facilitating the binding of RNA polymerase II holoenzyme to the proviral DNA (PubMed:11096080, PubMed:25149208). Binds (via DRBM domain 2) to the HIV-1 TAR RNA and stimulates HIV-1 transcription of transactivation response element (TAR)-containing mRNAs (PubMed:11096080, PubMed:9892698). Involved also in HIV-1 mRNA splicing and transport (PubMed:25149208). Positively regulates HIV-1 gag mRNA translation, through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Binds (via DRBM domains) to a HIV-1 double-stranded RNA region of the primer binding site (PBS)-segment of the 5'-UTR, and hence stimulates DHX9 incorporation into virions and virion infectivity (PubMed:27107641). Also plays a role as a cytosolic viral MyD88-dependent DNA and RNA sensors in plasmacytoid dendritic cells (pDCs), and hence induce antiviral innate immune responses (PubMed:20696886, PubMed:21957149). Binds (via the OB-fold region) to viral single-stranded DNA unmethylated C-phosphate-G (CpG) oligonucleotide (PubMed:20696886). {ECO:0000269|PubMed:11096080, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:20696886, ECO:0000269|PubMed:21957149, ECO:0000269|PubMed:25149208, ECO:0000269|PubMed:27107641, ECO:0000269|PubMed:9892698}. |
| Q0VG06 | FAAP100 | T672 | ochoa | Fanconi anemia core complex-associated protein 100 (Fanconi anemia-associated protein of 100 kDa) | Plays a role in Fanconi anemia-associated DNA damage response network. Regulates FANCD2 monoubiquitination and the stability of the FA core complex. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. {ECO:0000269|PubMed:17396147}. |
| Q12815 | TROAP | T341 | ochoa | Tastin (Trophinin-assisting protein) (Trophinin-associated protein) | Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. |
| Q13613 | MTMR1 | T46 | ochoa | Phosphatidylinositol-3-phosphate phosphatase MTMR1 (EC 3.1.3.-) (Myotubularin-related protein 1) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate, generating phosphatidylinositol (PubMed:11733541, PubMed:27018598). Could also dephosphorylate phosphatidylinositol 3,5-bisphosphate to produce phosphatidylinositol 5-phosphate (PubMed:27018598). {ECO:0000269|PubMed:11733541, ECO:0000269|PubMed:27018598}. |
| Q14126 | DSG2 | T650 | ochoa | Desmoglein-2 (Cadherin family member 5) (HDGC) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:38395410). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes (PubMed:29910125). Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells (PubMed:27338829). Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 (PubMed:27338829). Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier (PubMed:38395410). {ECO:0000250|UniProtKB:O55111, ECO:0000269|PubMed:27338829, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:38395410}. |
| Q14157 | UBAP2L | T294 | ochoa | Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}. |
| Q14157 | UBAP2L | T863 | ochoa | Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}. |
| Q14164 | IKBKE | T501 | psp | Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i) | Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' also seems to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1. {ECO:0000269|PubMed:17568778, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:19153231, ECO:0000269|PubMed:20188669, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:22532683, ECO:0000269|PubMed:23453969, ECO:0000269|PubMed:23478265}. |
| Q14517 | FAT1 | T4286 | ochoa | Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form] | [Protocadherin Fat 1]: Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. {ECO:0000250}. |
| Q14676 | MDC1 | T1133 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | T1379 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | T1420 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | T1461 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | T1625 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | T1666 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14814 | MEF2D | T259 | ochoa | Myocyte-specific enhancer factor 2D | Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). {ECO:0000250, ECO:0000269|PubMed:10849446, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:15834131}. |
| Q15021 | NCAPD2 | T586 | ochoa | Condensin complex subunit 1 (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (hCAP-D2) (Non-SMC condensin I complex subunit D2) (XCAP-D2 homolog) | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}. |
| Q15714 | TSC22D1 | T1052 | ochoa | TSC22 domain family protein 1 (Cerebral protein 2) (HUCEP-2) (Regulatory protein TSC-22) (TGFB-stimulated clone 22 homolog) (Transforming growth factor beta-1-induced transcript 4 protein) | Transcriptional repressor (PubMed:10488076). Acts on the C-type natriuretic peptide (CNP) promoter (PubMed:9022669). Acts to promote CASP3-mediated apoptosis (PubMed:18325344). Positively regulates TGF-beta signaling by interacting with SMAD7 which inhibits binding of SMAD7 to TGFBR1, preventing recruitment of SMURF ubiquitin ligases to TGFBR1 and inhibiting SMURF-mediated ubiquitination and degradation of TGFBR1 (PubMed:21791611). Contributes to enhancement of TGF-beta signaling by binding to and modulating the transcription activator activity of SMAD4 (PubMed:15881652). Promotes TGF-beta-induced transcription of COL1A2; via its interaction with TFE3 at E-boxes in the gene proximal promoter (By similarity). Plays a role in the repression of hematopoietic precursor cell growth (By similarity). Promotes IL2 deprivation-induced apoptosis in T-lymphocytes, via repression of TSC22D3/GILZ transcription and activation of the caspase cascade (PubMed:26752201). {ECO:0000250|UniProtKB:P62500, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:15881652, ECO:0000269|PubMed:18325344, ECO:0000269|PubMed:21791611, ECO:0000269|PubMed:26752201, ECO:0000269|PubMed:9022669}.; FUNCTION: [Isoform 1]: May act to negatively regulate TGFB3 signaling and thereby inhibit cell death in mammary gland cells. {ECO:0000250|UniProtKB:P62500}.; FUNCTION: [Isoform 2]: Positively regulates cell death in response to TGFB3 during mammary gland involution. {ECO:0000250|UniProtKB:P62500}. |
| Q15717 | ELAVL1 | T118 | psp | ELAV-like protein 1 (Hu-antigen R) (HuR) | RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462, PubMed:31358969). Involved in embryonic stem cell (ESC) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESC differentiation (By similarity). Has also been shown to be capable of binding to m6A-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398, PubMed:17632515, PubMed:18285462, PubMed:23519412, PubMed:8626503). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR (PubMed:29180010). {ECO:0000250|UniProtKB:P70372, ECO:0000269|PubMed:14517288, ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:17632515, ECO:0000269|PubMed:18285462, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:23519412, ECO:0000269|PubMed:29180010, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:32245947, ECO:0000269|PubMed:8626503}. |
| Q15811 | ITSN1 | T839 | psp | Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17) | Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery (PubMed:11584276, PubMed:29887380). Acts as a guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (PubMed:11584276). Plays a role in the assembly and maturation of clathrin-coated vesicles (By similarity). Recruits FCHSD2 to clathrin-coated pits (PubMed:29887380). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2 (PubMed:22648170). Promotes ubiquitination and subsequent degradation of EGFR, and thereby contributes to the down-regulation of EGFR-dependent signaling pathways. In chromaffin cells, required for normal exocytosis of catecholamines. Required for rapid replenishment of release-ready synaptic vesicles at presynaptic active zones (By similarity). Inhibits ARHGAP31 activity toward RAC1 (PubMed:11744688). {ECO:0000250|UniProtKB:Q9WVE9, ECO:0000250|UniProtKB:Q9Z0R4, ECO:0000269|PubMed:11584276, ECO:0000269|PubMed:11744688, ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:29887380}.; FUNCTION: [Isoform 1]: Plays a role in synaptic vesicle endocytosis in brain neurons. {ECO:0000250|UniProtKB:Q9Z0R4}. |
| Q16513 | PKN2 | T116 | ochoa | Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2) | PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747). {ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11777936, ECO:0000269|PubMed:11781095, ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:15364941, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:27104747, ECO:0000269|PubMed:9121475}.; FUNCTION: (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. {ECO:0000269|PubMed:15364941}. |
| Q2M2I8 | AAK1 | T362 | ochoa | AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1) | Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis (PubMed:11877457, PubMed:11877461, PubMed:12952931, PubMed:14617351, PubMed:17494869, PubMed:25653444). Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1 (PubMed:17494869). Preferentially, may phosphorylate substrates on threonine residues (PubMed:11877457, PubMed:18657069). Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes (PubMed:12952931). Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes (PubMed:18657069). Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (PubMed:21464124). {ECO:0000269|PubMed:11877457, ECO:0000269|PubMed:11877461, ECO:0000269|PubMed:12952931, ECO:0000269|PubMed:14617351, ECO:0000269|PubMed:17494869, ECO:0000269|PubMed:18657069, ECO:0000269|PubMed:21464124, ECO:0000269|PubMed:25653444}.; FUNCTION: (Microbial infection) By regulating clathrin-mediated endocytosis, AAK1 plays a role in the entry of hepatitis C virus as well as for the lifecycle of other viruses such as Ebola and Dengue. {ECO:0000269|PubMed:25653444, ECO:0000305|PubMed:31136173}. |
| Q2VPK5 | CTU2 | T426 | ochoa | Cytoplasmic tRNA 2-thiolation protein 2 (Cytosolic thiouridylase subunit 2) | Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. {ECO:0000255|HAMAP-Rule:MF_03054, ECO:0000269|PubMed:19017811}. |
| Q3YEC7 | RABL6 | T496 | ochoa | Rab-like protein 6 (GTP-binding protein Parf) (Partner of ARF) (Rab-like protein 1) (RBEL1) | May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A. {ECO:0000269|PubMed:16582619}. |
| Q4VCS5 | AMOT | T709 | ochoa | Angiomotin | Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Repressor of YAP1 and WWTR1/TAZ transcription of target genes, potentially via regulation of Hippo signaling-mediated phosphorylation of YAP1 which results in its recruitment to tight junctions (PubMed:21205866). {ECO:0000269|PubMed:11257124, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:21205866}. |
| Q5JPB2 | ZNF831 | T921 | ochoa | Zinc finger protein 831 | None |
| Q5T5Y3 | CAMSAP1 | T466 | ochoa | Calmodulin-regulated spectrin-associated protein 1 | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24117850, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). {ECO:0000269|PubMed:19508979, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24117850, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919}. |
| Q5TEJ8 | THEMIS2 | T593 | ochoa | Protein THEMIS2 (Induced by contact to basement membrane 1 protein) (Protein ICB-1) (Thymocyte-expressed molecule involved in selection protein 2) | May constitute a control point in macrophage inflammatory response, promoting LPS-induced TLR4-mediated TNF production (PubMed:20644716). Determines the threshold for activation of B cells by low-affinity and low-avidity ligands via PLCG2 activation and its downstream pathways (By similarity). {ECO:0000250|UniProtKB:Q91YX0, ECO:0000269|PubMed:20644716}. |
| Q6MZP7 | LIN54 | T237 | ochoa | Protein lin-54 homolog (CXC domain-containing protein 1) | Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context (PubMed:17531812, PubMed:17671431). In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes (PubMed:17531812, PubMed:17671431). In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation (PubMed:17531812, PubMed:17671431). In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner (PubMed:19725879). Specifically recognizes the consensus motif 5'-TTYRAA-3' in target DNA (PubMed:27465258). {ECO:0000269|PubMed:17531812, ECO:0000269|PubMed:17671431, ECO:0000269|PubMed:19725879, ECO:0000269|PubMed:27465258}. |
| Q6P1L5 | FAM117B | T111 | ochoa | Protein FAM117B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein) | None |
| Q6P1N0 | CC2D1A | T470 | ochoa | Coiled-coil and C2 domain-containing protein 1A (Akt kinase-interacting protein 1) (Five prime repressor element under dual repression-binding protein 1) (FRE under dual repression-binding protein 1) (Freud-1) (Putative NF-kappa-B-activating protein 023N) | Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis. {ECO:0000250, ECO:0000269|PubMed:20171170}. |
| Q6P4R8 | NFRKB | T863 | ochoa | Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B) (INO80 complex subunit G) | Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. {ECO:0000269|PubMed:18922472}.; FUNCTION: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex. {ECO:0000269|PubMed:18922472}. |
| Q6PJ61 | FBXO46 | T195 | ochoa | F-box only protein 46 (F-box only protein 34-like) | Substrate-recognition component of the SCF(FBXO46) protein ligase complex, which mediates the ubiquitination and degradation of target proteins (PubMed:30171069). In absence of stress, the SCF(FBXO46) complex catalyzes ubiquitination and degradation of MTOR-phosphorylated FBXO31 (PubMed:30171069). {ECO:0000269|PubMed:30171069}. |
| Q6PKG0 | LARP1 | T138 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q6ZTU2 | EP400P1 | T203 | ochoa | Putative EP400-like protein (EP400 pseudogene 1) | None |
| Q76N89 | HECW1 | T558 | ochoa | E3 ubiquitin-protein ligase HECW1 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECW1) (NEDD4-like E3 ubiquitin-protein ligase 1) (hNEDL1) | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS. {ECO:0000269|PubMed:14684739}. |
| Q7L2J0 | MEPCE | T287 | ochoa | 7SK snRNA methylphosphate capping enzyme (MePCE) (EC 2.1.1.-) (Bicoid-interacting protein 3 homolog) (Bin3 homolog) | S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723, PubMed:38100593). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723). Also required for stability of U6 snRNAs (PubMed:38100593). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:19906723, ECO:0000269|PubMed:28254838, ECO:0000269|PubMed:30559425, ECO:0000269|PubMed:38100593}. |
| Q7Z2Z1 | TICRR | T1265 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q7Z406 | MYH14 | T1953 | ochoa | Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. {ECO:0000250}. |
| Q86TC9 | MYPN | T412 | ochoa | Myopalladin (145 kDa sarcomeric protein) | Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines. {ECO:0000269|PubMed:11309420}. |
| Q86UP2 | KTN1 | T149 | ochoa | Kinectin (CG-1 antigen) (Kinesin receptor) | Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin. |
| Q86XJ1 | GAS2L3 | T623 | ochoa | GAS2-like protein 3 (Growth arrest-specific protein 2-like 3) | Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network. {ECO:0000269|PubMed:21561867}. |
| Q86YV5 | PRAG1 | T834 | ochoa | Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223) | Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). {ECO:0000250|UniProtKB:D3ZMK9, ECO:0000250|UniProtKB:Q571I4}. |
| Q8IVN3 | MUSTN1 | T63 | ochoa | Musculoskeletal embryonic nuclear protein 1 | Required for chondrocyte development and proliferation. Plays a role in myoblast differentiation and fusion. Modulates skeletal muscle extracellular matrix composition. Plays a role in skeletal muscle function. Plays a role in glucose homeostasis. {ECO:0000250|UniProtKB:Q99JI1}. |
| Q8IVT2 | MISP | T219 | ochoa | Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) | Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}. |
| Q8IVW6 | ARID3B | T64 | ochoa | AT-rich interactive domain-containing protein 3B (ARID domain-containing protein 3B) (Bright and dead ringer protein) (Bright-like protein) | Transcription factor which may be involved in neuroblastoma growth and malignant transformation. Favors nuclear targeting of ARID3A. {ECO:0000269|PubMed:16951138, ECO:0000269|PubMed:17400556}. |
| Q8N1G0 | ZNF687 | T379 | ochoa | Zinc finger protein 687 | May be involved in transcriptional regulation. |
| Q8N3E9 | PLCD3 | T37 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-3) (Phospholipase C-delta-3) (PLC-delta-3) | Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow (PubMed:10336610). Regulates neurite outgrowth through the inhibition of RhoA/Rho kinase signaling (By similarity). {ECO:0000250|UniProtKB:Q8K2J0, ECO:0000269|PubMed:10336610}. |
| Q8N6C5 | IGSF1 | T1291 | ochoa | Immunoglobulin superfamily member 1 (IgSF1) (Immunoglobulin-like domain-containing protein 1) (Inhibin-binding protein) (InhBP) (Pituitary gland-specific factor 2) (p120) | Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B (By similarity). Necessary to mediate a specific antagonistic effect of inhibin B on activin-stimulated transcription. {ECO:0000250, ECO:0000269|PubMed:11266516}. |
| Q8NC56 | LEMD2 | T24 | ochoa | LEM domain-containing protein 2 (hLEM2) | Nuclear lamina-associated inner nuclear membrane protein that is involved in nuclear structure organization, maintenance of nuclear envelope (NE) integrity and NE reformation after mitosis (PubMed:16339967, PubMed:17097643, PubMed:28242692, PubMed:32494070). Plays a role as transmembrane adapter for the endosomal sorting complexes required for transport (ESCRT), and is thereby involved in ESCRT-mediated NE reformation (PubMed:28242692, PubMed:32494070). Promotes ESCRT-mediated NE closure by recruiting CHMP7 and downstream ESCRT-III proteins IST1/CHMP8 and CHMP2A to the reforming NE during anaphase (PubMed:28242692). During nuclear reassembly, condenses into a liquid-like coating around microtubule spindles and coassembles with CHMP7 to form a macromolecular O-ring seal at the confluence between membranes, chromatin, and the spindle to facilitate early nuclear sealing (PubMed:32494070). Plays a role in the organization of heterochromatin associated with the NE and in the maintenance of NE organization under mechanical stress (By similarity). Required for embryonic development and involved in regulation of several signaling pathways such as MAPK and AKT (By similarity). Required for myoblast differentiation involving regulation of ERK signaling (By similarity). Essential for cardiac homeostasis and proper heart function (By similarity). {ECO:0000250|UniProtKB:Q6DVA0, ECO:0000269|PubMed:16339967, ECO:0000269|PubMed:17097643, ECO:0000269|PubMed:28242692, ECO:0000269|PubMed:32494070}. |
| Q8NFA2 | NOXO1 | T333 | ochoa | NADPH oxidase organizer 1 (NADPH oxidase regulatory protein) (Nox organizer 1) (Nox-organizing protein 1) (SH3 and PX domain-containing protein 5) | Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity. {ECO:0000269|PubMed:12657628, ECO:0000269|PubMed:14617635, ECO:0000269|PubMed:15326186, ECO:0000269|PubMed:15824103, ECO:0000269|PubMed:15949904, ECO:0000269|PubMed:16329988, ECO:0000269|PubMed:17126813, ECO:0000269|PubMed:19755710}. |
| Q8TBN0 | RAB3IL1 | T26 | ochoa | Guanine nucleotide exchange factor for Rab-3A (Rab-3A-interacting-like protein 1) (Rab3A-interacting-like protein 1) (Rabin3-like 1) | Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May also activate RAB8A and RAB8B. {ECO:0000269|PubMed:20937701}. |
| Q8TD19 | NEK9 | T333 | ochoa|psp | Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8) | Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation (PubMed:12101123, PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2 (PubMed:11864968). Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues (PubMed:11864968). Important for G1/S transition and S phase progression (PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (PubMed:12840024, PubMed:14660563, PubMed:19941817, PubMed:26522158). {ECO:0000269|PubMed:11864968, ECO:0000269|PubMed:12101123, ECO:0000269|PubMed:12840024, ECO:0000269|PubMed:14660563, ECO:0000269|PubMed:19941817, ECO:0000269|PubMed:26522158}. |
| Q8TEQ6 | GEMIN5 | T807 | ochoa | Gem-associated protein 5 (Gemin5) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:16857593, PubMed:18984161, PubMed:20513430, PubMed:33963192). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate (PubMed:18984161). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, GEMIN5 recognizes and delivers the small nuclear RNAs (snRNAs) to the SMN complex (PubMed:11714716, PubMed:16314521, PubMed:16857593, PubMed:19377484, PubMed:19750007, PubMed:20513430, PubMed:27834343, PubMed:27881600, PubMed:27881601). Binds to the 7-methylguanosine cap of RNA molecules (PubMed:19750007, PubMed:27834343, PubMed:27881600, PubMed:27881601, Ref.27). Binds to the 3'-UTR of SMN1 mRNA and regulates its translation; does not affect mRNA stability (PubMed:25911097). May play a role in the regulation of protein synthesis via its interaction with ribosomes (PubMed:27507887). {ECO:0000269|PubMed:11714716, ECO:0000269|PubMed:16314521, ECO:0000269|PubMed:16857593, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19377484, ECO:0000269|PubMed:19750007, ECO:0000269|PubMed:20513430, ECO:0000269|PubMed:25911097, ECO:0000269|PubMed:27507887, ECO:0000269|PubMed:27834343, ECO:0000269|PubMed:27881600, ECO:0000269|PubMed:27881601, ECO:0000269|PubMed:33963192, ECO:0000269|Ref.27}. |
| Q92574 | TSC1 | T300 | ochoa | Hamartin (Tuberous sclerosis 1 protein) | Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12906785, PubMed:15340059, PubMed:24529379, PubMed:28215400). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12906785, PubMed:15340059, PubMed:24529379). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12271141, PubMed:24529379, PubMed:28215400, PubMed:33215753). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Within the TSC-TBC complex, TSC1 stabilizes TSC2 and prevents TSC2 self-aggregation (PubMed:10585443, PubMed:28215400). Acts as a tumor suppressor (PubMed:9242607). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155). {ECO:0000250|UniProtKB:Q9Z136, ECO:0000269|PubMed:10585443, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:16464865, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:29127155, ECO:0000269|PubMed:33215753, ECO:0000269|PubMed:9242607}. |
| Q92613 | JADE3 | T625 | ochoa | Protein Jade-3 (Jade family PHD finger protein 3) (PHD finger protein 16) | Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. {ECO:0000269|PubMed:16387653}. |
| Q92851 | CASP10 | T270 | ochoa | Caspase-10 (CASP-10) (EC 3.4.22.63) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) (ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12] | Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP8 and CASP9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. {ECO:0000269|PubMed:11717445, ECO:0000269|PubMed:16916640}.; FUNCTION: Isoform 7 can enhance NF-kappaB activity but promotes only slight apoptosis. {ECO:0000269|PubMed:17822854}.; FUNCTION: Isoform C is proteolytically inactive. {ECO:0000269|PubMed:11717445}. |
| Q92870 | APBB2 | T312 | ochoa | Amyloid beta precursor protein binding family B member 2 (Amyloid-beta (A4) precursor protein-binding family B member 2) (Protein Fe65-like 1) | Plays a role in the maintenance of lens transparency, and may also play a role in muscle cell strength (By similarity). Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning (By similarity). Activates transcription of APP (PubMed:14527950). {ECO:0000250|UniProtKB:Q9DBR4, ECO:0000269|PubMed:14527950}. |
| Q93073 | SECISBP2L | T437 | ochoa | Selenocysteine insertion sequence-binding protein 2-like (SECIS-binding protein 2-like) | Binds SECIS (Sec insertion sequence) elements present on selenocysteine (Sec) protein mRNAs, but does not promote Sec incorporation into selenoproteins in vitro. |
| Q96AY4 | TTC28 | T42 | ochoa | Tetratricopeptide repeat protein 28 (TPR repeat protein 28) (TPR repeat-containing big gene cloned at Keio) | During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody. {ECO:0000269|PubMed:23036704}. |
| Q96HC4 | PDLIM5 | T355 | ochoa | PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein) | May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation. {ECO:0000250|UniProtKB:Q62920}. |
| Q96JK2 | DCAF5 | T489 | ochoa | DDB1- and CUL4-associated factor 5 (Breakpoint cluster region protein 2) (BCRP2) (WD repeat-containing protein 22) | Is a substrate receptor for the CUL4-DDB1 E3 ubiquitin-protein ligase complex (CRL4) (PubMed:29691401, PubMed:30442713). The complex CRL4-DCAF5 is involved in the ubiquitination of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1 (PubMed:29691401, PubMed:30442713). {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:29691401, ECO:0000269|PubMed:30442713}. |
| Q96KQ7 | EHMT2 | T171 | ochoa | Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Lysine N-methyltransferase 1C) (Protein G9a) | Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself. {ECO:0000250|UniProtKB:Q9Z148, ECO:0000269|PubMed:11316813, ECO:0000269|PubMed:18438403, ECO:0000269|PubMed:20084102, ECO:0000269|PubMed:20118233, ECO:0000269|PubMed:22387026, ECO:0000269|PubMed:8457211}. |
| Q96KQ7 | EHMT2 | T172 | ochoa | Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Lysine N-methyltransferase 1C) (Protein G9a) | Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself. {ECO:0000250|UniProtKB:Q9Z148, ECO:0000269|PubMed:11316813, ECO:0000269|PubMed:18438403, ECO:0000269|PubMed:20084102, ECO:0000269|PubMed:20118233, ECO:0000269|PubMed:22387026, ECO:0000269|PubMed:8457211}. |
| Q96L91 | EP400 | T214 | ochoa | E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein) | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}. |
| Q96PK6 | RBM14 | T579 | ochoa | RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein) | Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CPAP complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CPAP (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also involved in the regulation of pre-mRNA alternative splicing (PubMed:37548402). {ECO:0000269|PubMed:11443112, ECO:0000269|PubMed:25385835, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:37548402}. |
| Q99459 | CDC5L | T429 | ochoa | Cell division cycle 5-like protein (Cdc5-like protein) (Pombe cdc5-related protein) | DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:11991638, PubMed:20176811, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30705154, PubMed:30728453). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR) (PubMed:20176811). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:10570151, ECO:0000269|PubMed:11082045, ECO:0000269|PubMed:11101529, ECO:0000269|PubMed:11544257, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:18583928, ECO:0000269|PubMed:20176811, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:9038199, ECO:0000269|PubMed:9468527, ECO:0000269|PubMed:9632794, ECO:0000305|PubMed:33509932}. |
| Q99569 | PKP4 | T308 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q99959 | PKP2 | T248 | ochoa | Plakophilin-2 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:25208567). Regulates focal adhesion turnover resulting in changes in focal adhesion size, cell adhesion and cell spreading, potentially via transcriptional modulation of beta-integrins (PubMed:23884246). Required to maintain gingival epithelial barrier function (PubMed:34368962). Important component of the desmosome that is also required for localization of desmosome component proteins such as DSC2, DSG2 and JUP to the desmosome cell-cell junction (PubMed:22781308, PubMed:25208567). Required for the formation of desmosome cell junctions in cardiomyocytes, thereby required for the correct formation of the heart, specifically trabeculation and formation of the atria walls (By similarity). Loss of desmosome cell junctions leads to mis-localization of DSP and DSG2 resulting in disruption of cell-cell adhesion and disordered intermediate filaments (By similarity). Modulates profibrotic gene expression in cardiomyocytes via regulation of DSP expression and subsequent activation of downstream TGFB1 and MAPK14/p38 MAPK signaling (By similarity). Required for cardiac sodium current propagation and electrical synchrony in cardiac myocytes, via ANK3 stabilization and modulation of SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). Required for mitochondrial function, nuclear envelope integrity and positive regulation of SIRT3 transcription via maintaining DES localization at its nuclear envelope and cell tip anchoring points, and thereby preserving regulation of the transcriptional program (PubMed:35959657). Maintenance of nuclear envelope integrity protects against DNA damage and transcriptional dysregulation of genes, especially those involved in the electron transport chain, thereby preserving mitochondrial function and protecting against superoxide radical anion generation (PubMed:35959657). Binds single-stranded DNA (ssDNA) (PubMed:20613778). May regulate the localization of GJA1 to gap junctions in intercalated disks of the heart (PubMed:18662195). Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). Acts as a host restriction factor for IAV viral propagation, potentially via disrupting the interaction of IAV polymerase complex proteins (PubMed:28169297). {ECO:0000250|UniProtKB:F1M7L9, ECO:0000250|UniProtKB:Q9CQ73, ECO:0000269|PubMed:18662195, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:22781308, ECO:0000269|PubMed:23884246, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:28169297, ECO:0000269|PubMed:34368962, ECO:0000269|PubMed:35959657}. |
| Q9BQ15 | NABP2 | T117 | psp | SOSS complex subunit B1 (Nucleic acid-binding protein 2) (Oligonucleotide/oligosaccharide-binding fold-containing protein 2B) (Sensor of single-strand DNA complex subunit B1) (Sensor of ssDNA subunit B1) (SOSS-B1) (Single-stranded DNA-binding protein 1) (hSSB1) | Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint (PubMed:25249620). In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. {ECO:0000269|PubMed:18449195, ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501, ECO:0000269|PubMed:25249620}. |
| Q9BQ95 | ECSIT | T254 | ochoa | Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (Protein SITPEC) | Adapter protein that plays a role in different signaling pathways including TLRs and IL-1 pathways or innate antiviral induction signaling. Plays a role in the activation of NF-kappa-B by forming a signal complex with TRAF6 and TAK1/MAP3K7 to activate TAK1/MAP3K7 leading to activation of IKKs (PubMed:25355951, PubMed:31281713). Once ubiquitinated, interacts with the dissociated RELA and NFKB1 proteins and translocates to the nucleus where it induces NF-kappa-B-dependent gene expression (PubMed:25355951). Plays a role in innate antiviral immune response by bridging the pattern recognition receptors RIGI and MDA5/IFIT1 to the MAVS complex at the mitochondrion (PubMed:25228397). Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity). {ECO:0000250, ECO:0000269|PubMed:25228397, ECO:0000269|PubMed:25355951, ECO:0000269|PubMed:31281713}.; FUNCTION: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I. {ECO:0000269|PubMed:32320651}. |
| Q9BTC8 | MTA3 | T455 | ochoa | Metastasis-associated protein MTA3 | Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:12705869, PubMed:16428440, PubMed:28977666). Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels (PubMed:12705869). Contributes to transcriptional repression by BCL6 (PubMed:15454082). {ECO:0000269|PubMed:12705869, ECO:0000269|PubMed:15454082, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| Q9BUL5 | PHF23 | T155 | ochoa | PHD finger protein 23 (PDH-containing protein JUNE-1) | Acts as a negative regulator of autophagy, through promoting ubiquitination and degradation of LRSAM1, an E3 ubiquitin ligase that promotes autophagy in response to starvation or infecting bacteria. {ECO:0000269|PubMed:25484098}. |
| Q9BX66 | SORBS1 | T862 | ochoa | Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}. |
| Q9BXB5 | OSBPL10 | T217 | ochoa | Oxysterol-binding protein-related protein 10 (ORP-10) (OSBP-related protein 10) | Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (Probable) (PubMed:23934110). Plays a role in negative regulation of lipid biosynthesis (PubMed:19554302). Negatively regulates APOB secretion from hepatocytes (PubMed:19554302, PubMed:22906437). Binds cholesterol and acidic phospholipids (PubMed:22906437). Also binds 25-hydroxycholesterol (PubMed:17428193). Binds phosphatidylserine (PubMed:23934110). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:19554302, ECO:0000269|PubMed:22906437, ECO:0000269|PubMed:23934110, ECO:0000305}. |
| Q9BY77 | POLDIP3 | T138 | ochoa | Polymerase delta-interacting protein 3 (46 kDa DNA polymerase delta interaction protein) (p46) (S6K1 Aly/REF-like target) (SKAR) | Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by association with the TREX complex. {ECO:0000269|PubMed:18423201, ECO:0000269|PubMed:22928037}. |
| Q9C0B5 | ZDHHC5 | T524 | ochoa | Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401, ECO:0000269|PubMed:38092000, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}. |
| Q9C0C7 | AMBRA1 | T1210 | ochoa | Activating molecule in BECN1-regulated autophagy protein 1 (DDB1- and CUL4-associated factor 3) | Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex involved in cell cycle control and autophagy (PubMed:20921139, PubMed:23524951, PubMed:24587252, PubMed:32333458, PubMed:33854232, PubMed:33854235, PubMed:33854239). The DCX(AMBRA1) complex specifically mediates the polyubiquitination of target proteins such as BECN1, CCND1, CCND2, CCND3, ELOC and ULK1 (PubMed:23524951, PubMed:33854232, PubMed:33854235, PubMed:33854239). Acts as an upstream master regulator of the transition from G1 to S cell phase: AMBRA1 specifically recognizes and binds phosphorylated cyclin-D (CCND1, CCND2 and CCND3), leading to cyclin-D ubiquitination by the DCX(AMBRA1) complex and subsequent degradation (PubMed:33854232, PubMed:33854235, PubMed:33854239). By controlling the transition from G1 to S phase and cyclin-D degradation, AMBRA1 acts as a tumor suppressor that promotes genomic integrity during DNA replication and counteracts developmental abnormalities and tumor growth (PubMed:33854232, PubMed:33854235, PubMed:33854239). AMBRA1 also regulates the cell cycle by promoting MYC dephosphorylation and degradation independently of the DCX(AMBRA1) complex: acts via interaction with the catalytic subunit of protein phosphatase 2A (PPP2CA), which enhances interaction between PPP2CA and MYC, leading to MYC dephosphorylation and degradation (PubMed:25438055, PubMed:25803737). Acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (ELOC) component of CRL5 complexes (PubMed:25499913, PubMed:30166453). Acts as a key regulator of autophagy by modulating the BECN1-PIK3C3 complex: controls protein turnover during neuronal development, and regulates normal cell survival and proliferation (PubMed:21358617). In normal conditions, AMBRA1 is tethered to the cytoskeleton via interaction with dyneins DYNLL1 and DYNLL2 (PubMed:20921139). Upon autophagy induction, AMBRA1 is released from the cytoskeletal docking site to induce autophagosome nucleation by mediating ubiquitination of proteins involved in autophagy (PubMed:20921139). The DCX(AMBRA1) complex mediates 'Lys-63'-linked ubiquitination of BECN1, increasing the association between BECN1 and PIK3C3 to promote PIK3C3 activity (By similarity). In collaboration with TRAF6, AMBRA1 mediates 'Lys-63'-linked ubiquitination of ULK1 following autophagy induction, promoting ULK1 stability and kinase activity (PubMed:23524951). Also activates ULK1 via interaction with TRIM32: TRIM32 stimulates ULK1 through unanchored 'Lys-63'-linked polyubiquitin chains (PubMed:31123703). Also acts as an activator of mitophagy via interaction with PRKN and LC3 proteins (MAP1LC3A, MAP1LC3B or MAP1LC3C); possibly by bringing damaged mitochondria onto autophagosomes (PubMed:21753002, PubMed:25215947). Also activates mitophagy by acting as a cofactor for HUWE1; acts by promoting HUWE1-mediated ubiquitination of MFN2 (PubMed:30217973). AMBRA1 is also involved in regulatory T-cells (Treg) differentiation by promoting FOXO3 dephosphorylation independently of the DCX(AMBRA1) complex: acts via interaction with PPP2CA, which enhances interaction between PPP2CA and FOXO3, leading to FOXO3 dephosphorylation and stabilization (PubMed:30513302). May act as a regulator of intracellular trafficking, regulating the localization of active PTK2/FAK and SRC (By similarity). Also involved in transcription regulation by acting as a scaffold for protein complexes at chromatin (By similarity). {ECO:0000250|UniProtKB:A2AH22, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21358617, ECO:0000269|PubMed:21753002, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:24587252, ECO:0000269|PubMed:25215947, ECO:0000269|PubMed:25438055, ECO:0000269|PubMed:25499913, ECO:0000269|PubMed:25803737, ECO:0000269|PubMed:30166453, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:30513302, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:32333458, ECO:0000269|PubMed:33854232, ECO:0000269|PubMed:33854235, ECO:0000269|PubMed:33854239}. |
| Q9GZY8 | MFF | T121 | ochoa | Mitochondrial fission factor | Plays a role in mitochondrial and peroxisomal fission (PubMed:18353969, PubMed:23530241, PubMed:24196833). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (PubMed:23530241). May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity). {ECO:0000250|UniProtKB:Q4KM98, ECO:0000269|PubMed:18353969, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:24196833}. |
| Q9H2P0 | ADNP | T440 | ochoa | Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein) | May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z103}. |
| Q9H3F6 | KCTD10 | T27 | ochoa | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 (hBACURD3) (BTB/POZ domain-containing protein KCTD10) (Potassium channel tetramerization domain-containing protein 10) | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity). {ECO:0000250|UniProtKB:Q8WZ19}. |
| Q9H7N4 | SCAF1 | T673 | ochoa | Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) | May function in pre-mRNA splicing. {ECO:0000250}. |
| Q9HAU0 | PLEKHA5 | T862 | ochoa | Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2) | None |
| Q9HBM6 | TAF9B | T159 | ochoa | Transcription initiation factor TFIID subunit 9B (Neuronal cell death-related protein 7) (DN-7) (Transcription initiation factor TFIID subunit 9-like) (Transcription-associated factor TAFII31L) | Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription. {ECO:0000269|PubMed:15899866}. |
| Q9NP74 | PALMD | T276 | ochoa | Palmdelphin (Paralemmin-like protein) | None |
| Q9NR12 | PDLIM7 | T105 | ochoa | PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma) | May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). {ECO:0000250, ECO:0000269|PubMed:11874232, ECO:0000269|PubMed:7929196}. |
| Q9NS82 | SLC7A10 | T26 | ochoa | Asc-type amino acid transporter 1 (Asc-1) (Solute carrier family 7 member 10) | Associates with SLC3A2/4F2hc to form a functional heterodimeric complex that translocates small neutral L- and D-amino acids across the plasma membrane. Preferentially mediates exchange transport, but can also operate via facilitated diffusion (By similarity) (PubMed:10863037). Acts as a major transporter for glycine, L- and D-serine in the central nervous system. At the spinal cord and brainstem regulates glycine metabolism and glycinergic inhibitory neurotransmission by providing for glycine de novo synthesis from L-serine and glycine recycling from astrocytes to glycinergic motor neurons (By similarity). At Schaffer collateral-CA1 synapses mediates D-serine and glycine release that modulates post-synaptic activation of NMDA receptors and excitatory glutamatergic transmission (By similarity). May regulate D-serine release from mesenchymal progenitors located in developing subcutaneous adipose tissue, favoring white adipocyte over thermogenic beige adipocyte lineage commitment (By similarity). {ECO:0000250|UniProtKB:P63115, ECO:0000250|UniProtKB:P63116, ECO:0000269|PubMed:10863037}. |
| Q9NUA8 | ZBTB40 | T221 | ochoa | Zinc finger and BTB domain-containing protein 40 | May be involved in transcriptional regulation. |
| Q9NW07 | ZNF358 | T550 | ochoa | Zinc finger protein 358 | May be involved in transcriptional regulation. |
| Q9NZI8 | IGF2BP1 | T528 | ochoa | Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2 mRNA-binding protein 1) (IMP-1) (IMP1) (Coding region determinant-binding protein) (CRD-BP) (IGF-II mRNA-binding protein 1) (VICKZ family member 1) (Zipcode-binding protein 1) (ZBP-1) | RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed:29476152, PubMed:32245947). Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons (By similarity). Regulates localized beta-actin/ACTB mRNA translation, a crucial process for cell polarity, cell migration and neurite outgrowth. Co-transcriptionally associates with the ACTB mRNA in the nucleus. This binding involves a conserved 54-nucleotide element in the ACTB mRNA 3'-UTR, known as the 'zipcode'. The RNP thus formed is exported to the cytoplasm, binds to a motor protein and is transported along the cytoskeleton to the cell periphery. During transport, prevents ACTB mRNA from being translated into protein. When the RNP complex reaches its destination near the plasma membrane, IGF2BP1 is phosphorylated. This releases the mRNA, allowing ribosomal 40S and 60S subunits to assemble and initiate ACTB protein synthesis. Monomeric ACTB then assembles into the subcortical actin cytoskeleton (By similarity). During neuronal development, key regulator of neurite outgrowth, growth cone guidance and neuronal cell migration, presumably through the spatiotemporal fine tuning of protein synthesis, such as that of ACTB (By similarity). May regulate mRNA transport to activated synapses (By similarity). Binds to and stabilizes ABCB1/MDR-1 mRNA (By similarity). During interstinal wound repair, interacts with and stabilizes PTGS2 transcript. PTGS2 mRNA stabilization may be crucial for colonic mucosal wound healing (By similarity). Binds to the 3'-UTR of IGF2 mRNA by a mechanism of cooperative and sequential dimerization and regulates IGF2 mRNA subcellular localization and translation. Binds to MYC mRNA, in the coding region instability determinant (CRD) of the open reading frame (ORF), hence preventing MYC cleavage by endonucleases and possibly microRNA targeting to MYC-CRD (PubMed:29476152). Binding to MYC mRNA is enhanced by m6A-modification of the CRD (PubMed:29476152). Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to the oncofetal H19 transcript and to the neuron-specific TAU mRNA and regulates their localizations. Binds to and stabilizes BTRC/FBW1A mRNA. Binds to the adenine-rich autoregulatory sequence (ARS) located in PABPC1 mRNA and represses its translation. PABPC1 mRNA-binding is stimulated by PABPC1 protein. Prevents BTRC/FBW1A mRNA degradation by disrupting microRNA-dependent interaction with AGO2. Promotes the directed movement of tumor-derived cells by fine-tuning intracellular signaling networks. Binds to MAPK4 3'-UTR and inhibits its translation. Interacts with PTEN transcript open reading frame (ORF) and prevents mRNA decay. This combined action on MAPK4 (down-regulation) and PTEN (up-regulation) antagonizes HSPB1 phosphorylation, consequently it prevents G-actin sequestration by phosphorylated HSPB1, allowing F-actin polymerization. Hence enhances the velocity of cell migration and stimulates directed cell migration by PTEN-modulated polarization. Interacts with Hepatitis C virus (HCV) 5'-UTR and 3'-UTR and specifically enhances translation at the HCV IRES, but not 5'-cap-dependent translation, possibly by recruiting eIF3. Interacts with HIV-1 GAG protein and blocks the formation of infectious HIV-1 particles. Reduces HIV-1 assembly by inhibiting viral RNA packaging, as well as assembly and processing of GAG protein on cellular membranes. During cellular stress, such as oxidative stress or heat shock, stabilizes target mRNAs that are recruited to stress granules, including CD44, IGF2, MAPK4, MYC, PTEN, RAPGEF2 and RPS6KA5 transcripts. {ECO:0000250, ECO:0000269|PubMed:10875929, ECO:0000269|PubMed:16356927, ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:16778892, ECO:0000269|PubMed:17101699, ECO:0000269|PubMed:17255263, ECO:0000269|PubMed:17893325, ECO:0000269|PubMed:18385235, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19541769, ECO:0000269|PubMed:19647520, ECO:0000269|PubMed:20080952, ECO:0000269|PubMed:22279049, ECO:0000269|PubMed:29476152, ECO:0000269|PubMed:32245947, ECO:0000269|PubMed:8132663, ECO:0000269|PubMed:9891060}. |
| Q9P219 | CCDC88C | T1533 | ochoa | Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2) | Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426). {ECO:0000269|PubMed:26126266, ECO:0000269|PubMed:30948426}. |
| Q9UBF8 | PI4KB | T263 | ochoa | Phosphatidylinositol 4-kinase beta (PI4K-beta) (PI4Kbeta) (PtdIns 4-kinase beta) (EC 2.7.1.67) (NPIK) (PI4K92) (PI4KIII) | Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity) (PubMed:10559940, PubMed:11277933, PubMed:12749687, PubMed:9405935). May play an important role in the inner ear development. {ECO:0000250|UniProtKB:O08561, ECO:0000269|PubMed:10559940, ECO:0000269|PubMed:11277933, ECO:0000269|PubMed:12749687, ECO:0000269|PubMed:33358777, ECO:0000269|PubMed:9405935}.; FUNCTION: (Microbial infection) Plays an essential role in Aichi virus RNA replication (PubMed:22124328, PubMed:22258260, PubMed:27989622). Recruited by ACBD3 at the viral replication sites (PubMed:22124328, PubMed:27989622). {ECO:0000269|PubMed:22124328, ECO:0000269|PubMed:22258260, ECO:0000269|PubMed:27989622}.; FUNCTION: (Microbial infection) Required for cellular spike-mediated entry of human coronavirus SARS-CoV. {ECO:0000269|PubMed:22253445}. |
| Q9UJZ1 | STOML2 | T327 | ochoa | Stomatin-like protein 2, mitochondrial (SLP-2) (EPB72-like protein 2) (Paraprotein target 7) (Paratarg-7) | Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation. {ECO:0000269|PubMed:17121834, ECO:0000269|PubMed:18641330, ECO:0000269|PubMed:19597348, ECO:0000269|PubMed:19944461, ECO:0000269|PubMed:21746876, ECO:0000269|PubMed:22623988}. |
| Q9UMS6 | SYNPO2 | T845 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9UPP1 | PHF8 | T966 | ochoa | Histone lysine demethylase PHF8 (EC 1.14.11.27) (EC 1.14.11.65) (PHD finger protein 8) ([histone H3]-dimethyl-L-lysine(36) demethylase PHF8) ([histone H3]-dimethyl-L-lysine(9) demethylase PHF8) | Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3. Positively modulates transcription of histone demethylase KDM5C, acting synergistically with transcription factor ARX; synergy may be related to enrichment of histone H3K4me3 in regulatory elements. {ECO:0000269|PubMed:19843542, ECO:0000269|PubMed:20023638, ECO:0000269|PubMed:20101266, ECO:0000269|PubMed:20208542, ECO:0000269|PubMed:20346720, ECO:0000269|PubMed:20421419, ECO:0000269|PubMed:20531378, ECO:0000269|PubMed:20548336, ECO:0000269|PubMed:20622853, ECO:0000269|PubMed:20622854, ECO:0000269|PubMed:31691806}. |
| Q9Y3E7 | CHMP3 | T185 | ochoa | Charged multivesicular body protein 3 (Chromatin-modifying protein 3) (Neuroendocrine differentiation factor) (Vacuolar protein sorting-associated protein 24) (hVps24) | Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor. Isoform 2 prevents stress-mediated cell death and accumulation of reactive oxygen species when expressed in yeast cells. {ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:15707591, ECO:0000269|PubMed:16740483, ECO:0000269|PubMed:17331679, ECO:0000269|PubMed:18076377}. |
| Q9Y426 | C2CD2 | T471 | ochoa | C2 domain-containing protein 2 (Transmembrane protein 24-like) | None |
| Q9Y6I3 | EPN1 | T460 | ochoa | Epsin-1 (EH domain-binding mitotic phosphoprotein) (EPS-15-interacting protein 1) | Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis (PubMed:10393179, PubMed:10557078). {ECO:0000250|UniProtKB:O88339, ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:10557078}. |
| Q9Y6I3 | EPN1 | T467 | ochoa | Epsin-1 (EH domain-binding mitotic phosphoprotein) (EPS-15-interacting protein 1) | Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis (PubMed:10393179, PubMed:10557078). {ECO:0000250|UniProtKB:O88339, ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:10557078}. |
| Q9Y6M1 | IGF2BP2 | T550 | ochoa | Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2 mRNA-binding protein 2) (IMP-2) (Hepatocellular carcinoma autoantigen p62) (IGF-II mRNA-binding protein 2) (VICKZ family member 2) | RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed:29476152). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs (PubMed:9891060). Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (PubMed:29476152). {ECO:0000250, ECO:0000269|PubMed:23640942, ECO:0000269|PubMed:29476152, ECO:0000269|PubMed:9891060}. |
| Q9Y6N7 | ROBO1 | T1076 | ochoa | Roundabout homolog 1 (Deleted in U twenty twenty) (H-Robo-1) | Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed:10102268, PubMed:24560577). Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). May be required for lung development (By similarity). {ECO:0000250|UniProtKB:O89026, ECO:0000269|PubMed:10102268, ECO:0000269|PubMed:24560577, ECO:0000269|PubMed:26529257, ECO:0000305}. |
| P07858 | CTSB | T95 | Sugiyama | Cathepsin B (EC 3.4.22.1) (APP secretase) (APPS) (Cathepsin B1) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain] | Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (PubMed:12220505). Cleaves matrix extracellular phosphoglycoprotein MEPE (PubMed:12220505). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (PubMed:3972105). {ECO:0000250|UniProtKB:P10605, ECO:0000269|PubMed:12220505, ECO:0000269|PubMed:3972105}. |
| Q96G46 | DUS3L | T176 | Sugiyama | tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like (EC 1.3.1.89) (mRNA-dihydrouridine synthase DUS3L) (EC 1.3.1.-) (tRNA-dihydrouridine synthase 3-like) | Catalyzes the synthesis of dihydrouridine, a modified base, in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs) (PubMed:34556860). Mainly modifies the uridine in position 47 (U47) in the D-loop of most cytoplasmic tRNAs (PubMed:34556860). Also able to mediate the formation of dihydrouridine in some mRNAs, thereby regulating their translation (PubMed:34556860). {ECO:0000269|PubMed:34556860}. |
| Q9NVU7 | SDAD1 | T552 | Sugiyama | Protein SDA1 homolog (Nucleolar protein 130) (SDA1 domain-containing protein 1) (hSDA) | Required for 60S pre-ribosomal subunits export to the cytoplasm. {ECO:0000250}. |
| P04632 | CAPNS1 | T85 | Sugiyama | Calpain small subunit 1 (CSS1) (Calcium-activated neutral proteinase small subunit) (CANP small subunit) (Calcium-dependent protease small subunit) (CDPS) (Calcium-dependent protease small subunit 1) (Calpain regulatory subunit) | Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Essential for embryonic development (By similarity). {ECO:0000250|UniProtKB:O88456}. |
| P49368 | CCT3 | T430 | Sugiyama | T-complex protein 1 subunit gamma (TCP-1-gamma) (EC 3.6.1.-) (CCT-gamma) (Chaperonin containing T-complex polypeptide 1 subunit 3) (hTRiC5) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P26639 | TARS1 | T629 | Sugiyama | Threonine--tRNA ligase 1, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase 1) | Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) (PubMed:25824639, PubMed:31374204). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage (By similarity). {ECO:0000250|UniProtKB:Q9D0R2, ECO:0000269|PubMed:25824639, ECO:0000269|PubMed:31374204}. |
| P07602 | PSAP | T26 | Sugiyama | Prosaposin (Proactivator polypeptide) [Cleaved into: Saposin-A (Protein A); Saposin-B-Val; Saposin-B (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sphingolipid activator protein 1) (SAP-1) (Sulfatide/GM1 activator); Saposin-C (A1 activator) (Co-beta-glucosidase) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin-D (Component C) (Protein C)] | Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate.; FUNCTION: Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases.; FUNCTION: Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12).; FUNCTION: [Prosaposin]: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. {ECO:0000250|UniProtKB:Q61207, ECO:0000269|PubMed:10383054}.; FUNCTION: Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases. |
| Q562R1 | ACTBL2 | T107 | Sugiyama | Beta-actin-like protein 2 (Kappa-actin) | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. {ECO:0000250}. |
| P31948 | STIP1 | T260 | Sugiyama | Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521) | Acts as a co-chaperone for HSP90AA1 (PubMed:27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity). {ECO:0000250|UniProtKB:O35814, ECO:0000303|PubMed:27353360}. |
| P21333 | FLNA | Y470 | Sugiyama | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| Q99798 | ACO2 | T646 | Sugiyama | Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) | Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. {ECO:0000250|UniProtKB:P16276}. |
| Q13873 | BMPR2 | T805 | Sugiyama | Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade (PubMed:12045205). Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. Promotes signaling also by binding to activin A/INHBA (PubMed:24018044). {ECO:0000250|UniProtKB:O35607, ECO:0000269|PubMed:12045205, ECO:0000269|PubMed:24018044}. |
| P10809 | HSPD1 | T61 | Sugiyama | 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) | Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000305|PubMed:25918392}. |
| P53778 | MAPK12 | T49 | Sugiyama | Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration. {ECO:0000269|PubMed:10848581, ECO:0000269|PubMed:14592936, ECO:0000269|PubMed:17724032, ECO:0000269|PubMed:20605917, ECO:0000269|PubMed:21172807, ECO:0000269|PubMed:8633070, ECO:0000269|PubMed:9430721}. |
| Q99798 | ACO2 | T511 | Sugiyama | Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) | Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. {ECO:0000250|UniProtKB:P16276}. |
| P55809 | OXCT1 | T159 | Sugiyama | Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (SCOT) (EC 2.8.3.5) (3-oxoacid CoA-transferase 1) (Somatic-type succinyl-CoA:3-oxoacid CoA-transferase) (SCOT-s) (Succinyl-CoA:3-oxoacid CoA transferase) | Key enzyme for ketone body catabolism. Catalyzes the first, rate-limiting step of ketone body utilization in extrahepatic tissues, by transferring coenzyme A (CoA) from a donor thiolester species (succinyl-CoA) to an acceptor carboxylate (acetoacetate), and produces acetoacetyl-CoA. Acetoacetyl-CoA is further metabolized by acetoacetyl-CoA thiolase into two acetyl-CoA molecules which enter the citric acid cycle for energy production (PubMed:10964512). Forms a dimeric enzyme where both of the subunits are able to form enzyme-CoA thiolester intermediates, but only one subunit is competent to transfer the CoA moiety to the acceptor carboxylate (3-oxo acid) and produce a new acyl-CoA. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity). {ECO:0000250|UniProtKB:Q29551, ECO:0000269|PubMed:10964512}. |
| P62318 | SNRPD3 | T22 | Sugiyama | Small nuclear ribonucleoprotein Sm D3 (Sm-D3) (snRNP core protein D3) | Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:25555158, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:28781166). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (By similarity). {ECO:0000250|UniProtKB:P62320, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:25555158, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932}. |
| P15941 | MUC1 | T224 | iPTMNet | Mucin-1 (MUC-1) (Breast carcinoma-associated antigen DF3) (Cancer antigen 15-3) (CA 15-3) (Carcinoma-associated mucin) (Episialin) (H23AG) (Krebs von den Lungen-6) (KL-6) (PEMT) (Peanut-reactive urinary mucin) (PUM) (Polymorphic epithelial mucin) (PEM) (Tumor-associated epithelial membrane antigen) (EMA) (Tumor-associated mucin) (CD antigen CD227) [Cleaved into: Mucin-1 subunit alpha (MUC1-NT) (MUC1-alpha); Mucin-1 subunit beta (MUC1-beta) (MUC1-CT)] | The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.; FUNCTION: The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity. |
| P14314 | PRKCSH | T78 | Sugiyama | Glucosidase 2 subunit beta (80K-H protein) (Glucosidase II subunit beta) (Protein kinase C substrate 60.1 kDa protein heavy chain) (PKCSH) | Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). {ECO:0000250|UniProtKB:O08795, ECO:0000269|PubMed:10929008}. |
| Q8N8S7 | ENAH | T74 | Sugiyama | Protein enabled homolog | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity). {ECO:0000250, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:18158903}. |
| P61163 | ACTR1A | T111 | Sugiyama | Alpha-centractin (Centractin) (ARP1) (Actin-RPV) (Centrosome-associated actin homolog) | Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules. {ECO:0000250|UniProtKB:F2Z5G5}. |
| P05388 | RPLP0 | T122 | Sugiyama | Large ribosomal subunit protein uL10 (60S acidic ribosomal protein P0) (60S ribosomal protein L10E) | Ribosomal protein P0 is the functional equivalent of E.coli protein L10. |
| Q8NHW5 | RPLP0P6 | T122 | Sugiyama | Putative ribosomal protein uL10-like (60S acidic ribosomal protein P0-like) (Large ribosomal subunit protein uL10-like) | Ribosomal protein P0 is the functional equivalent of E.coli protein L10. {ECO:0000250}. |
| P50991 | CCT4 | T199 | Sugiyama | T-complex protein 1 subunit delta (TCP-1-delta) (EC 3.6.1.-) (CCT-delta) (Chaperonin containing T-complex polypeptide 1 subunit 4) (Stimulator of TAR RNA-binding) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| Q9NQS7 | INCENP | T494 | EPSD|PSP | Inner centromere protein | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}. |
| Q9Y2V2 | CARHSP1 | T48 | Sugiyama | Calcium-regulated heat-stable protein 1 (Calcium-regulated heat-stable protein of 24 kDa) (CRHSP-24) | Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro). {ECO:0000269|PubMed:21078874, ECO:0000269|PubMed:21177848}. |
| Q9UK32 | RPS6KA6 | T718 | Sugiyama | Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) | Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. {ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15632195}. |
| O94979 | SEC31A | Y804 | Sugiyama | Protein transport protein Sec31A (ABP125) (ABP130) (SEC31-like protein 1) (SEC31-related protein A) (Web1-like protein) | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (PubMed:10788476). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). {ECO:0000250|UniProtKB:Q9Z2Q1, ECO:0000269|PubMed:10788476}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 0.000040 | 4.394 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 0.000040 | 4.394 |
| R-HSA-191859 | snRNP Assembly | 0.000432 | 3.365 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.000432 | 3.365 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.000366 | 3.436 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.000317 | 3.499 |
| R-HSA-4839726 | Chromatin organization | 0.000525 | 3.280 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.000837 | 3.077 |
| R-HSA-525793 | Myogenesis | 0.001201 | 2.921 |
| R-HSA-8985801 | Regulation of cortical dendrite branching | 0.001538 | 2.813 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.002031 | 2.692 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.002627 | 2.580 |
| R-HSA-68875 | Mitotic Prophase | 0.003255 | 2.487 |
| R-HSA-1500931 | Cell-Cell communication | 0.003339 | 2.476 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.003763 | 2.424 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.004581 | 2.339 |
| R-HSA-5688890 | Defective CSF2RA causes SMDP4 | 0.005928 | 2.227 |
| R-HSA-5688849 | Defective CSF2RB causes SMDP5 | 0.005928 | 2.227 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.005878 | 2.231 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.005671 | 2.246 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.005481 | 2.261 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.005878 | 2.231 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.007715 | 2.113 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.007657 | 2.116 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.007657 | 2.116 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.007657 | 2.116 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.007657 | 2.116 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 0.007434 | 2.129 |
| R-HSA-5683826 | Surfactant metabolism | 0.006729 | 2.172 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.006330 | 2.199 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.005626 | 2.250 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.006729 | 2.172 |
| R-HSA-437239 | Recycling pathway of L1 | 0.008151 | 2.089 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.009093 | 2.041 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.009234 | 2.035 |
| R-HSA-426117 | Cation-coupled Chloride cotransporters | 0.009093 | 2.041 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.009651 | 2.015 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.009234 | 2.035 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.009234 | 2.035 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.010045 | 1.998 |
| R-HSA-196025 | Formation of annular gap junctions | 0.010901 | 1.963 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.011918 | 1.924 |
| R-HSA-190873 | Gap junction degradation | 0.012854 | 1.891 |
| R-HSA-5687868 | Defective SFTPA2 causes IPF | 0.014060 | 1.852 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.014269 | 1.846 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.016125 | 1.792 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.015724 | 1.803 |
| R-HSA-77108 | Utilization of Ketone Bodies | 0.017177 | 1.765 |
| R-HSA-428540 | Activation of RAC1 | 0.019537 | 1.709 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.019760 | 1.704 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.020826 | 1.681 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.021063 | 1.676 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 0.021063 | 1.676 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.022413 | 1.649 |
| R-HSA-5687613 | Diseases associated with surfactant metabolism | 0.022026 | 1.657 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.023809 | 1.623 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.023809 | 1.623 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.027863 | 1.555 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.028175 | 1.550 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.027451 | 1.561 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.025496 | 1.594 |
| R-HSA-68886 | M Phase | 0.029833 | 1.525 |
| R-HSA-9675108 | Nervous system development | 0.025833 | 1.588 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.027370 | 1.563 |
| R-HSA-446728 | Cell junction organization | 0.027352 | 1.563 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.025251 | 1.598 |
| R-HSA-1474244 | Extracellular matrix organization | 0.029188 | 1.535 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.029853 | 1.525 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.032448 | 1.489 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.033150 | 1.480 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.033150 | 1.480 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.031479 | 1.502 |
| R-HSA-1640170 | Cell Cycle | 0.031360 | 1.504 |
| R-HSA-422475 | Axon guidance | 0.031970 | 1.495 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 0.033177 | 1.479 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.034896 | 1.457 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.036245 | 1.441 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.038436 | 1.415 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.034896 | 1.457 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.037701 | 1.424 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.036245 | 1.441 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.036981 | 1.432 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.034742 | 1.459 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.038855 | 1.411 |
| R-HSA-2028269 | Signaling by Hippo | 0.039417 | 1.404 |
| R-HSA-162587 | HIV Life Cycle | 0.039656 | 1.402 |
| R-HSA-5619087 | Defective SLC12A3 causes Gitelman syndrome (GS) | 0.041591 | 1.381 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.055068 | 1.259 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.055068 | 1.259 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.055068 | 1.259 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.055068 | 1.259 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.055068 | 1.259 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.055068 | 1.259 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.055068 | 1.259 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.055068 | 1.259 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.055068 | 1.259 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.055068 | 1.259 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.055068 | 1.259 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.048709 | 1.312 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.049529 | 1.305 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.044290 | 1.354 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.042183 | 1.375 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.042691 | 1.370 |
| R-HSA-210991 | Basigin interactions | 0.053087 | 1.275 |
| R-HSA-194138 | Signaling by VEGF | 0.050284 | 1.299 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.050234 | 1.299 |
| R-HSA-418990 | Adherens junctions interactions | 0.054348 | 1.265 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.042599 | 1.371 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.045526 | 1.342 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.056673 | 1.247 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.068357 | 1.165 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.068357 | 1.165 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 0.060462 | 1.219 |
| R-HSA-391251 | Protein folding | 0.058250 | 1.235 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 0.068357 | 1.165 |
| R-HSA-8953854 | Metabolism of RNA | 0.062365 | 1.205 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.065876 | 1.181 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.068278 | 1.166 |
| R-HSA-75157 | FasL/ CD95L signaling | 0.068357 | 1.165 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.061636 | 1.210 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.058912 | 1.230 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.063514 | 1.197 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.057113 | 1.243 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.057113 | 1.243 |
| R-HSA-74182 | Ketone body metabolism | 0.064273 | 1.192 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.064670 | 1.189 |
| R-HSA-1296061 | HCN channels | 0.081459 | 1.089 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 0.081459 | 1.089 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 0.081459 | 1.089 |
| R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 0.107116 | 0.970 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.107116 | 0.970 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 0.119676 | 0.922 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 0.119676 | 0.922 |
| R-HSA-111367 | SLBP independent Processing of Histone Pre-mRNAs | 0.132060 | 0.879 |
| R-HSA-444257 | RSK activation | 0.144270 | 0.841 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.156310 | 0.806 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 0.156310 | 0.806 |
| R-HSA-68952 | DNA replication initiation | 0.168180 | 0.774 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.191425 | 0.718 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.202804 | 0.693 |
| R-HSA-69109 | Leading Strand Synthesis | 0.202804 | 0.693 |
| R-HSA-69091 | Polymerase switching | 0.202804 | 0.693 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.092997 | 1.032 |
| R-HSA-69166 | Removal of the Flap Intermediate | 0.225085 | 0.648 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 0.225085 | 0.648 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.097359 | 1.012 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.097359 | 1.012 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.235992 | 0.627 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.106252 | 0.974 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.106252 | 0.974 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.106252 | 0.974 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.110778 | 0.956 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.246746 | 0.608 |
| R-HSA-5083625 | Defective GALNT3 causes HFTC | 0.246746 | 0.608 |
| R-HSA-5083636 | Defective GALNT12 causes CRCS1 | 0.246746 | 0.608 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.115353 | 0.938 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 0.257350 | 0.589 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.267805 | 0.572 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.267805 | 0.572 |
| R-HSA-5083632 | Defective C1GALT1C1 causes TNPS | 0.267805 | 0.572 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.138898 | 0.857 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.278113 | 0.556 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.143726 | 0.842 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.143726 | 0.842 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.288277 | 0.540 |
| R-HSA-167161 | HIV Transcription Initiation | 0.153485 | 0.814 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.153485 | 0.814 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.298298 | 0.525 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.298298 | 0.525 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 0.308179 | 0.511 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.108749 | 0.964 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 0.317921 | 0.498 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.070548 | 1.152 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.188526 | 0.725 |
| R-HSA-977068 | Termination of O-glycan biosynthesis | 0.336998 | 0.472 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.136547 | 0.865 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.250530 | 0.601 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.297471 | 0.527 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.251154 | 0.600 |
| R-HSA-69186 | Lagging Strand Synthesis | 0.308179 | 0.511 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.318494 | 0.497 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.318494 | 0.497 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 0.235992 | 0.627 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.318494 | 0.497 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.173361 | 0.761 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.152936 | 0.815 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.179885 | 0.745 |
| R-HSA-167172 | Transcription of the HIV genome | 0.094380 | 1.025 |
| R-HSA-9796292 | Formation of axial mesoderm | 0.214023 | 0.670 |
| R-HSA-174430 | Telomere C-strand synthesis initiation | 0.235992 | 0.627 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.255747 | 0.592 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.163368 | 0.787 |
| R-HSA-77588 | SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | 0.144270 | 0.841 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.153485 | 0.814 |
| R-HSA-202433 | Generation of second messenger molecules | 0.143726 | 0.842 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.111720 | 0.952 |
| R-HSA-3928664 | Ephrin signaling | 0.278113 | 0.556 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.245317 | 0.610 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.224517 | 0.649 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.228049 | 0.642 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.225085 | 0.648 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.097620 | 1.010 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 0.081459 | 1.089 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.144270 | 0.841 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 0.168180 | 0.774 |
| R-HSA-380612 | Metabolism of serotonin | 0.168180 | 0.774 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.080277 | 1.095 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.214023 | 0.670 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.214023 | 0.670 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.088694 | 1.052 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.129355 | 0.888 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.173361 | 0.761 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.327527 | 0.485 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.287056 | 0.542 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.257350 | 0.589 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.109547 | 0.960 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.231033 | 0.636 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.130171 | 0.885 |
| R-HSA-390648 | Muscarinic acetylcholine receptors | 0.094378 | 1.025 |
| R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO | 0.156310 | 0.806 |
| R-HSA-8963888 | Chylomicron assembly | 0.179885 | 0.745 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.110778 | 0.956 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.278113 | 0.556 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.133863 | 0.873 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.292266 | 0.534 |
| R-HSA-1268020 | Mitochondrial protein import | 0.260967 | 0.583 |
| R-HSA-8964041 | LDL remodeling | 0.132060 | 0.879 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.144270 | 0.841 |
| R-HSA-1236973 | Cross-presentation of particulate exogenous antigens (phagosomes) | 0.168180 | 0.774 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.191425 | 0.718 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.191425 | 0.718 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 0.191425 | 0.718 |
| R-HSA-2142712 | Synthesis of 12-eicosatetraenoic acid derivatives | 0.235992 | 0.627 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.257350 | 0.589 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.308179 | 0.511 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.255747 | 0.592 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.292266 | 0.534 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.214167 | 0.669 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.072130 | 1.142 |
| R-HSA-3214842 | HDMs demethylate histones | 0.072130 | 1.142 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.084454 | 1.073 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.115353 | 0.938 |
| R-HSA-162906 | HIV Infection | 0.140481 | 0.852 |
| R-HSA-114608 | Platelet degranulation | 0.326192 | 0.487 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.082062 | 1.086 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.156310 | 0.806 |
| R-HSA-9683686 | Maturation of spike protein | 0.168180 | 0.774 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 0.202804 | 0.693 |
| R-HSA-380615 | Serotonin clearance from the synaptic cleft | 0.202804 | 0.693 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 0.202804 | 0.693 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.235992 | 0.627 |
| R-HSA-2142770 | Synthesis of 15-eicosatetraenoic acid derivatives | 0.267805 | 0.572 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.138898 | 0.857 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.143726 | 0.842 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.143726 | 0.842 |
| R-HSA-9694548 | Maturation of spike protein | 0.148589 | 0.828 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.148589 | 0.828 |
| R-HSA-2142688 | Synthesis of 5-eicosatetraenoic acids | 0.288277 | 0.540 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 0.288277 | 0.540 |
| R-HSA-8852135 | Protein ubiquitination | 0.114721 | 0.940 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.209009 | 0.680 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.216263 | 0.665 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.128915 | 0.890 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.306953 | 0.513 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.128915 | 0.890 |
| R-HSA-9664420 | Killing mechanisms | 0.246746 | 0.608 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 0.246746 | 0.608 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.110778 | 0.956 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.088710 | 1.052 |
| R-HSA-8866423 | VLDL assembly | 0.119676 | 0.922 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.202804 | 0.693 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.202804 | 0.693 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.202804 | 0.693 |
| R-HSA-8949664 | Processing of SMDT1 | 0.214023 | 0.670 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.225085 | 0.648 |
| R-HSA-171007 | p38MAPK events | 0.235992 | 0.627 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.235992 | 0.627 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.235992 | 0.627 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.110778 | 0.956 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.119976 | 0.921 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.134107 | 0.873 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.138898 | 0.857 |
| R-HSA-190828 | Gap junction trafficking | 0.168351 | 0.774 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.178394 | 0.749 |
| R-HSA-3214847 | HATs acetylate histones | 0.072405 | 1.140 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.336998 | 0.472 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.336998 | 0.472 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.074707 | 1.127 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.313048 | 0.504 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.130171 | 0.885 |
| R-HSA-73894 | DNA Repair | 0.294115 | 0.531 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.204437 | 0.689 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.082443 | 1.084 |
| R-HSA-5617833 | Cilium Assembly | 0.343565 | 0.464 |
| R-HSA-75158 | TRAIL signaling | 0.107116 | 0.970 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 0.156310 | 0.806 |
| R-HSA-5676594 | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | 0.214023 | 0.670 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.225085 | 0.648 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.138898 | 0.857 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.278113 | 0.556 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.193622 | 0.713 |
| R-HSA-373753 | Nephrin family interactions | 0.298298 | 0.525 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.079937 | 1.097 |
| R-HSA-74160 | Gene expression (Transcription) | 0.190321 | 0.721 |
| R-HSA-2892245 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | 0.132060 | 0.879 |
| R-HSA-1679131 | Trafficking and processing of endosomal TLR | 0.202804 | 0.693 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.080277 | 1.095 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.134107 | 0.873 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.317921 | 0.498 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.229706 | 0.639 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.260967 | 0.583 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.292266 | 0.534 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.257294 | 0.590 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.100029 | 1.000 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.209368 | 0.679 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.079305 | 1.101 |
| R-HSA-140875 | Common Pathway of Fibrin Clot Formation | 0.298298 | 0.525 |
| R-HSA-1266738 | Developmental Biology | 0.227561 | 0.643 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.318224 | 0.497 |
| R-HSA-70171 | Glycolysis | 0.074288 | 1.129 |
| R-HSA-373760 | L1CAM interactions | 0.114550 | 0.941 |
| R-HSA-168249 | Innate Immune System | 0.205809 | 0.687 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.246746 | 0.608 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.114721 | 0.940 |
| R-HSA-71384 | Ethanol oxidation | 0.327527 | 0.485 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.229706 | 0.639 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.114721 | 0.940 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.308179 | 0.511 |
| R-HSA-69206 | G1/S Transition | 0.318494 | 0.497 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.160646 | 0.794 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.156310 | 0.806 |
| R-HSA-196836 | Vitamin C (ascorbate) metabolism | 0.308179 | 0.511 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.183450 | 0.736 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.306953 | 0.513 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.192918 | 0.715 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.144270 | 0.841 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.168180 | 0.774 |
| R-HSA-167044 | Signalling to RAS | 0.308179 | 0.511 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 0.317921 | 0.498 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.291594 | 0.535 |
| R-HSA-373755 | Semaphorin interactions | 0.266187 | 0.575 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.080868 | 1.092 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.278113 | 0.556 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.260967 | 0.583 |
| R-HSA-5689603 | UCH proteinases | 0.333697 | 0.477 |
| R-HSA-162582 | Signal Transduction | 0.109186 | 0.962 |
| R-HSA-9020933 | Interleukin-23 signaling | 0.144270 | 0.841 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.283935 | 0.547 |
| R-HSA-421270 | Cell-cell junction organization | 0.092638 | 1.033 |
| R-HSA-9707616 | Heme signaling | 0.260967 | 0.583 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.127024 | 0.896 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.245317 | 0.610 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.333697 | 0.477 |
| R-HSA-70326 | Glucose metabolism | 0.116893 | 0.932 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.092997 | 1.032 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.107650 | 0.968 |
| R-HSA-2262752 | Cellular responses to stress | 0.220837 | 0.656 |
| R-HSA-8983711 | OAS antiviral response | 0.202804 | 0.693 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.338832 | 0.470 |
| R-HSA-1474290 | Collagen formation | 0.183861 | 0.736 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.318224 | 0.497 |
| R-HSA-1483255 | PI Metabolism | 0.216263 | 0.665 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.336998 | 0.472 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.117753 | 0.929 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.101778 | 0.992 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.288277 | 0.540 |
| R-HSA-73887 | Death Receptor Signaling | 0.228049 | 0.642 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.246190 | 0.609 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.159718 | 0.797 |
| R-HSA-75153 | Apoptotic execution phase | 0.178394 | 0.749 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.156286 | 0.806 |
| R-HSA-9679506 | SARS-CoV Infections | 0.196348 | 0.707 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.102903 | 0.988 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.278113 | 0.556 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.328550 | 0.483 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.327527 | 0.485 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.276626 | 0.558 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.343956 | 0.463 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.346336 | 0.461 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.346336 | 0.461 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 0.346336 | 0.461 |
| R-HSA-9659379 | Sensory processing of sound | 0.349067 | 0.457 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.349327 | 0.457 |
| R-HSA-199991 | Membrane Trafficking | 0.349835 | 0.456 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.353115 | 0.452 |
| R-HSA-68877 | Mitotic Prometaphase | 0.353143 | 0.452 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.354165 | 0.451 |
| R-HSA-9833482 | PKR-mediated signaling | 0.354165 | 0.451 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.355543 | 0.449 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.355543 | 0.449 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.355543 | 0.449 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.355543 | 0.449 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.359248 | 0.445 |
| R-HSA-168256 | Immune System | 0.359980 | 0.444 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.364621 | 0.438 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.364621 | 0.438 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.364621 | 0.438 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.369371 | 0.433 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.373572 | 0.428 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.373572 | 0.428 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.373572 | 0.428 |
| R-HSA-201451 | Signaling by BMP | 0.373572 | 0.428 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 0.373572 | 0.428 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.373572 | 0.428 |
| R-HSA-264876 | Insulin processing | 0.373572 | 0.428 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.374409 | 0.427 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.374409 | 0.427 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.382397 | 0.417 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.382397 | 0.417 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.382397 | 0.417 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.382397 | 0.417 |
| R-HSA-5620971 | Pyroptosis | 0.382397 | 0.417 |
| R-HSA-9664407 | Parasite infection | 0.383722 | 0.416 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.383722 | 0.416 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.383722 | 0.416 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.386481 | 0.413 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.386858 | 0.412 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.387527 | 0.412 |
| R-HSA-1632852 | Macroautophagy | 0.387527 | 0.412 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.389424 | 0.410 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.389424 | 0.410 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.391099 | 0.408 |
| R-HSA-72086 | mRNA Capping | 0.391099 | 0.408 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.391099 | 0.408 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.391099 | 0.408 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.391099 | 0.408 |
| R-HSA-70268 | Pyruvate metabolism | 0.394393 | 0.404 |
| R-HSA-6805567 | Keratinization | 0.397770 | 0.400 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.399678 | 0.398 |
| R-HSA-2424491 | DAP12 signaling | 0.399678 | 0.398 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.399678 | 0.398 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.399678 | 0.398 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.399678 | 0.398 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.399678 | 0.398 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.399678 | 0.398 |
| R-HSA-112311 | Neurotransmitter clearance | 0.399678 | 0.398 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 0.408137 | 0.389 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.408137 | 0.389 |
| R-HSA-182971 | EGFR downregulation | 0.408137 | 0.389 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.408137 | 0.389 |
| R-HSA-186763 | Downstream signal transduction | 0.408137 | 0.389 |
| R-HSA-69190 | DNA strand elongation | 0.416477 | 0.380 |
| R-HSA-1538133 | G0 and Early G1 | 0.416477 | 0.380 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.418957 | 0.378 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.423810 | 0.373 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.424701 | 0.372 |
| R-HSA-354192 | Integrin signaling | 0.424701 | 0.372 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.424701 | 0.372 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.424701 | 0.372 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.424701 | 0.372 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.424701 | 0.372 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.424701 | 0.372 |
| R-HSA-68882 | Mitotic Anaphase | 0.429362 | 0.367 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.432500 | 0.364 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.432683 | 0.364 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.432809 | 0.364 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.436395 | 0.360 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.438241 | 0.358 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.440803 | 0.356 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.440803 | 0.356 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 0.440803 | 0.356 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.440803 | 0.356 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.440803 | 0.356 |
| R-HSA-1989781 | PPARA activates gene expression | 0.443792 | 0.353 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.443792 | 0.353 |
| R-HSA-9612973 | Autophagy | 0.447477 | 0.349 |
| R-HSA-187687 | Signalling to ERKs | 0.448685 | 0.348 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.451152 | 0.346 |
| R-HSA-9610379 | HCMV Late Events | 0.451152 | 0.346 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 0.456456 | 0.341 |
| R-HSA-8853659 | RET signaling | 0.456456 | 0.341 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.456456 | 0.341 |
| R-HSA-9824446 | Viral Infection Pathways | 0.460162 | 0.337 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.460515 | 0.337 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.461850 | 0.335 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 0.464118 | 0.333 |
| R-HSA-4641258 | Degradation of DVL | 0.464118 | 0.333 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.464118 | 0.333 |
| R-HSA-212436 | Generic Transcription Pathway | 0.467788 | 0.330 |
| R-HSA-195721 | Signaling by WNT | 0.469323 | 0.329 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.471673 | 0.326 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.475735 | 0.323 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.479122 | 0.320 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.479122 | 0.320 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.486466 | 0.313 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.486466 | 0.313 |
| R-HSA-167169 | HIV Transcription Elongation | 0.486466 | 0.313 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.486466 | 0.313 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.486466 | 0.313 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.486466 | 0.313 |
| R-HSA-5260271 | Diseases of Immune System | 0.486466 | 0.313 |
| R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 0.486466 | 0.313 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.486466 | 0.313 |
| R-HSA-5619102 | SLC transporter disorders | 0.487321 | 0.312 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.493707 | 0.307 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 0.493707 | 0.307 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 0.493707 | 0.307 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.493707 | 0.307 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.500846 | 0.300 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.500846 | 0.300 |
| R-HSA-9683701 | Translation of Structural Proteins | 0.500846 | 0.300 |
| R-HSA-189451 | Heme biosynthesis | 0.500846 | 0.300 |
| R-HSA-72306 | tRNA processing | 0.501468 | 0.300 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.502845 | 0.299 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.502845 | 0.299 |
| R-HSA-211000 | Gene Silencing by RNA | 0.502845 | 0.299 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.507276 | 0.295 |
| R-HSA-165159 | MTOR signalling | 0.507886 | 0.294 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.507886 | 0.294 |
| R-HSA-913531 | Interferon Signaling | 0.509928 | 0.292 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.511680 | 0.291 |
| R-HSA-9710421 | Defective pyroptosis | 0.514826 | 0.288 |
| R-HSA-8854214 | TBC/RABGAPs | 0.514826 | 0.288 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.515414 | 0.288 |
| R-HSA-202403 | TCR signaling | 0.516059 | 0.287 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.518869 | 0.285 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.521669 | 0.283 |
| R-HSA-2172127 | DAP12 interactions | 0.521669 | 0.283 |
| R-HSA-69236 | G1 Phase | 0.521669 | 0.283 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.521669 | 0.283 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.521669 | 0.283 |
| R-HSA-373752 | Netrin-1 signaling | 0.521669 | 0.283 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.528415 | 0.277 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.528415 | 0.277 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.528415 | 0.277 |
| R-HSA-168255 | Influenza Infection | 0.532553 | 0.274 |
| R-HSA-9609646 | HCMV Infection | 0.532604 | 0.274 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.533313 | 0.273 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.535067 | 0.272 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.535067 | 0.272 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.535067 | 0.272 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.535067 | 0.272 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.541782 | 0.266 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.543873 | 0.265 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.548092 | 0.261 |
| R-HSA-8963899 | Plasma lipoprotein remodeling | 0.548092 | 0.261 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.554285 | 0.256 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.554468 | 0.256 |
| R-HSA-9766229 | Degradation of CDH1 | 0.554468 | 0.256 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.554468 | 0.256 |
| R-HSA-69275 | G2/M Transition | 0.555967 | 0.255 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.558399 | 0.253 |
| R-HSA-5693538 | Homology Directed Repair | 0.558399 | 0.253 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.562486 | 0.250 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.562486 | 0.250 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.562528 | 0.250 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.566952 | 0.246 |
| R-HSA-9864848 | Complex IV assembly | 0.566952 | 0.246 |
| R-HSA-3371556 | Cellular response to heat stress | 0.570579 | 0.244 |
| R-HSA-72187 | mRNA 3'-end processing | 0.573063 | 0.242 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.573063 | 0.242 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.573063 | 0.242 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.573063 | 0.242 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.573063 | 0.242 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.579087 | 0.237 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.579087 | 0.237 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.580985 | 0.236 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.581856 | 0.235 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.582515 | 0.235 |
| R-HSA-9609690 | HCMV Early Events | 0.588178 | 0.230 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.590884 | 0.228 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.596659 | 0.224 |
| R-HSA-177929 | Signaling by EGFR | 0.596659 | 0.224 |
| R-HSA-75893 | TNF signaling | 0.596659 | 0.224 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.599660 | 0.222 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.601864 | 0.221 |
| R-HSA-5621480 | Dectin-2 family | 0.602352 | 0.220 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.607965 | 0.216 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.607965 | 0.216 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.607965 | 0.216 |
| R-HSA-180786 | Extension of Telomeres | 0.613500 | 0.212 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 0.613500 | 0.212 |
| R-HSA-72172 | mRNA Splicing | 0.615865 | 0.211 |
| R-HSA-9843745 | Adipogenesis | 0.616853 | 0.210 |
| R-HSA-9658195 | Leishmania infection | 0.618107 | 0.209 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.618107 | 0.209 |
| R-HSA-5357801 | Programmed Cell Death | 0.618863 | 0.208 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.618956 | 0.208 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.618956 | 0.208 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.618956 | 0.208 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.618956 | 0.208 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.618956 | 0.208 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.618956 | 0.208 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.618956 | 0.208 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.618956 | 0.208 |
| R-HSA-379724 | tRNA Aminoacylation | 0.618956 | 0.208 |
| R-HSA-9909396 | Circadian clock | 0.620533 | 0.207 |
| R-HSA-1442490 | Collagen degradation | 0.624336 | 0.205 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.629640 | 0.201 |
| R-HSA-186797 | Signaling by PDGF | 0.629640 | 0.201 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.629725 | 0.201 |
| R-HSA-392499 | Metabolism of proteins | 0.630608 | 0.200 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.634870 | 0.197 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.634870 | 0.197 |
| R-HSA-6799198 | Complex I biogenesis | 0.634870 | 0.197 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.634870 | 0.197 |
| R-HSA-8848021 | Signaling by PTK6 | 0.634870 | 0.197 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.640026 | 0.194 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.645529 | 0.190 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.648992 | 0.188 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.650122 | 0.187 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.650122 | 0.187 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.650122 | 0.187 |
| R-HSA-1483257 | Phospholipid metabolism | 0.653384 | 0.185 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 0.655063 | 0.184 |
| R-HSA-913709 | O-linked glycosylation of mucins | 0.659936 | 0.180 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 0.659936 | 0.180 |
| R-HSA-5218859 | Regulated Necrosis | 0.659936 | 0.180 |
| R-HSA-9840310 | Glycosphingolipid catabolism | 0.669475 | 0.174 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.669475 | 0.174 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.669475 | 0.174 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.669475 | 0.174 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.669475 | 0.174 |
| R-HSA-6798695 | Neutrophil degranulation | 0.672307 | 0.172 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.674145 | 0.171 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.674145 | 0.171 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.674145 | 0.171 |
| R-HSA-189445 | Metabolism of porphyrins | 0.674145 | 0.171 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.678749 | 0.168 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.678749 | 0.168 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.678749 | 0.168 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.678964 | 0.168 |
| R-HSA-69242 | S Phase | 0.682163 | 0.166 |
| R-HSA-166520 | Signaling by NTRKs | 0.682163 | 0.166 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.683288 | 0.165 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.686027 | 0.164 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.687763 | 0.163 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.687763 | 0.163 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 0.687763 | 0.163 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.691138 | 0.160 |
| R-HSA-380287 | Centrosome maturation | 0.692175 | 0.160 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.692175 | 0.160 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.692175 | 0.160 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.694699 | 0.158 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.694699 | 0.158 |
| R-HSA-9609507 | Protein localization | 0.697769 | 0.156 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.700814 | 0.154 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.705043 | 0.152 |
| R-HSA-216083 | Integrin cell surface interactions | 0.705043 | 0.152 |
| R-HSA-191273 | Cholesterol biosynthesis | 0.705043 | 0.152 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.717375 | 0.144 |
| R-HSA-977225 | Amyloid fiber formation | 0.717375 | 0.144 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.721370 | 0.142 |
| R-HSA-109581 | Apoptosis | 0.724263 | 0.140 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.725309 | 0.139 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.729193 | 0.137 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.730349 | 0.136 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.733022 | 0.135 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.733022 | 0.135 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.736798 | 0.133 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.736798 | 0.133 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.736798 | 0.133 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.744189 | 0.128 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.747807 | 0.126 |
| R-HSA-156902 | Peptide chain elongation | 0.747807 | 0.126 |
| R-HSA-5688426 | Deubiquitination | 0.748417 | 0.126 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.748776 | 0.126 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.751374 | 0.124 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.754891 | 0.122 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 0.754891 | 0.122 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.758358 | 0.120 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.758358 | 0.120 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.761573 | 0.118 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.761777 | 0.118 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.765147 | 0.116 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.765147 | 0.116 |
| R-HSA-611105 | Respiratory electron transport | 0.768978 | 0.114 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.771746 | 0.113 |
| R-HSA-2559583 | Cellular Senescence | 0.773803 | 0.111 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.774976 | 0.111 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.778160 | 0.109 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.778160 | 0.109 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.778160 | 0.109 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.781300 | 0.107 |
| R-HSA-1296071 | Potassium Channels | 0.781300 | 0.107 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.781300 | 0.107 |
| R-HSA-157579 | Telomere Maintenance | 0.784395 | 0.105 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.784395 | 0.105 |
| R-HSA-5663205 | Infectious disease | 0.786316 | 0.104 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.787447 | 0.104 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.787447 | 0.104 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.787447 | 0.104 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.792237 | 0.101 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.793421 | 0.100 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.793421 | 0.100 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.796346 | 0.099 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.799229 | 0.097 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.800949 | 0.096 |
| R-HSA-1643685 | Disease | 0.801334 | 0.096 |
| R-HSA-192823 | Viral mRNA Translation | 0.802072 | 0.096 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.804874 | 0.094 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.807637 | 0.093 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.807637 | 0.093 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.810361 | 0.091 |
| R-HSA-449147 | Signaling by Interleukins | 0.811814 | 0.091 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.813047 | 0.090 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.815694 | 0.088 |
| R-HSA-69239 | Synthesis of DNA | 0.815694 | 0.088 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.818305 | 0.087 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.818305 | 0.087 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.818305 | 0.087 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.820878 | 0.086 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.820878 | 0.086 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.821332 | 0.085 |
| R-HSA-597592 | Post-translational protein modification | 0.822667 | 0.085 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.823416 | 0.084 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.823416 | 0.084 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.824662 | 0.084 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.825547 | 0.083 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.828383 | 0.082 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.828383 | 0.082 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.828383 | 0.082 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.830815 | 0.080 |
| R-HSA-1280218 | Adaptive Immune System | 0.831286 | 0.080 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.837905 | 0.077 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.840202 | 0.076 |
| R-HSA-397014 | Muscle contraction | 0.841582 | 0.075 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.842467 | 0.074 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.842467 | 0.074 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.844700 | 0.073 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.853320 | 0.069 |
| R-HSA-73886 | Chromosome Maintenance | 0.853320 | 0.069 |
| R-HSA-1660662 | Glycosphingolipid metabolism | 0.857450 | 0.067 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.857450 | 0.067 |
| R-HSA-8957322 | Metabolism of steroids | 0.866826 | 0.062 |
| R-HSA-69481 | G2/M Checkpoints | 0.867275 | 0.062 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.872843 | 0.059 |
| R-HSA-72312 | rRNA processing | 0.873159 | 0.059 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.878179 | 0.056 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.880097 | 0.055 |
| R-HSA-157118 | Signaling by NOTCH | 0.884091 | 0.054 |
| R-HSA-109582 | Hemostasis | 0.886894 | 0.052 |
| R-HSA-5173105 | O-linked glycosylation | 0.888190 | 0.051 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.888190 | 0.051 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.888283 | 0.051 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.889777 | 0.051 |
| R-HSA-6807070 | PTEN Regulation | 0.891342 | 0.050 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.905583 | 0.043 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.906962 | 0.042 |
| R-HSA-9758941 | Gastrulation | 0.907160 | 0.042 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.908479 | 0.042 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.908479 | 0.042 |
| R-HSA-2142753 | Arachidonate metabolism | 0.911061 | 0.040 |
| R-HSA-69306 | DNA Replication | 0.912324 | 0.040 |
| R-HSA-112316 | Neuronal System | 0.917424 | 0.037 |
| R-HSA-9711097 | Cellular response to starvation | 0.918380 | 0.037 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.920683 | 0.036 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.925083 | 0.034 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.925099 | 0.034 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.925099 | 0.034 |
| R-HSA-418555 | G alpha (s) signalling events | 0.933208 | 0.030 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.933208 | 0.030 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.934159 | 0.030 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.935095 | 0.029 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.936687 | 0.028 |
| R-HSA-3781865 | Diseases of glycosylation | 0.944564 | 0.025 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.946131 | 0.024 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.951316 | 0.022 |
| R-HSA-5668914 | Diseases of metabolism | 0.953837 | 0.021 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.955934 | 0.020 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.955934 | 0.020 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.955998 | 0.020 |
| R-HSA-428157 | Sphingolipid metabolism | 0.956562 | 0.019 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.957791 | 0.019 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.957791 | 0.019 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.963438 | 0.016 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.963960 | 0.016 |
| R-HSA-8951664 | Neddylation | 0.967874 | 0.014 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.971773 | 0.012 |
| R-HSA-15869 | Metabolism of nucleotides | 0.974107 | 0.011 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.980585 | 0.009 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.981732 | 0.008 |
| R-HSA-418594 | G alpha (i) signalling events | 0.984460 | 0.007 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.986655 | 0.006 |
| R-HSA-72766 | Translation | 0.988205 | 0.005 |
| R-HSA-388396 | GPCR downstream signalling | 0.988815 | 0.005 |
| R-HSA-500792 | GPCR ligand binding | 0.992485 | 0.003 |
| R-HSA-372790 | Signaling by GPCR | 0.995264 | 0.002 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.995865 | 0.002 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.995925 | 0.002 |
| R-HSA-556833 | Metabolism of lipids | 0.996320 | 0.002 |
| R-HSA-211859 | Biological oxidations | 0.996452 | 0.002 |
| R-HSA-8978868 | Fatty acid metabolism | 0.997849 | 0.001 |
| R-HSA-382551 | Transport of small molecules | 0.998771 | 0.001 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999902 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
GAK |
0.853 | 0.037 | 1 | 0.893 |
VRK2 |
0.844 | 0.019 | 1 | 0.917 |
MPSK1 |
0.842 | 0.194 | 1 | 0.859 |
PKR |
0.838 | -0.006 | 1 | 0.876 |
LKB1 |
0.838 | 0.062 | -3 | 0.813 |
VRK1 |
0.838 | -0.055 | 2 | 0.876 |
TAK1 |
0.837 | -0.083 | 1 | 0.829 |
LRRK2 |
0.836 | -0.048 | 2 | 0.875 |
JNK2 |
0.835 | 0.182 | 1 | 0.750 |
GCK |
0.835 | 0.019 | 1 | 0.797 |
PBK |
0.833 | 0.085 | 1 | 0.825 |
PDK1 |
0.832 | -0.010 | 1 | 0.817 |
PASK |
0.832 | 0.113 | -3 | 0.898 |
P38B |
0.832 | 0.202 | 1 | 0.754 |
ICK |
0.832 | 0.199 | -3 | 0.881 |
MOS |
0.831 | 0.153 | 1 | 0.888 |
MAP3K15 |
0.831 | 0.013 | 1 | 0.780 |
TNIK |
0.831 | -0.017 | 3 | 0.768 |
P38A |
0.830 | 0.176 | 1 | 0.823 |
DAPK2 |
0.830 | 0.033 | -3 | 0.892 |
JNK3 |
0.830 | 0.157 | 1 | 0.782 |
MAK |
0.830 | 0.273 | -2 | 0.856 |
ASK1 |
0.830 | -0.068 | 1 | 0.766 |
MINK |
0.829 | -0.075 | 1 | 0.798 |
BRAF |
0.829 | -0.071 | -4 | 0.531 |
KHS1 |
0.829 | 0.005 | 1 | 0.784 |
CDKL1 |
0.829 | 0.149 | -3 | 0.860 |
BMPR2 |
0.829 | -0.070 | -2 | 0.879 |
LATS1 |
0.828 | 0.126 | -3 | 0.869 |
NIK |
0.828 | -0.032 | -3 | 0.895 |
NEK1 |
0.828 | -0.069 | 1 | 0.831 |
MEK1 |
0.827 | -0.139 | 2 | 0.874 |
BIKE |
0.826 | 0.033 | 1 | 0.793 |
CAMLCK |
0.826 | 0.020 | -2 | 0.838 |
CAMKK2 |
0.826 | -0.059 | -2 | 0.757 |
MEKK2 |
0.825 | -0.083 | 2 | 0.833 |
MEK5 |
0.825 | -0.163 | 2 | 0.855 |
NLK |
0.825 | 0.106 | 1 | 0.919 |
KHS2 |
0.825 | -0.009 | 1 | 0.794 |
NEK5 |
0.824 | -0.053 | 1 | 0.856 |
MST3 |
0.824 | -0.019 | 2 | 0.865 |
MEKK6 |
0.824 | -0.075 | 1 | 0.811 |
ALK4 |
0.824 | -0.021 | -2 | 0.817 |
HGK |
0.824 | -0.066 | 3 | 0.767 |
PRPK |
0.824 | -0.005 | -1 | 0.854 |
HPK1 |
0.824 | -0.043 | 1 | 0.777 |
TTK |
0.823 | -0.070 | -2 | 0.799 |
TAO3 |
0.823 | -0.009 | 1 | 0.809 |
HIPK1 |
0.823 | 0.196 | 1 | 0.853 |
DLK |
0.823 | -0.049 | 1 | 0.839 |
MST2 |
0.822 | -0.109 | 1 | 0.806 |
TAO2 |
0.822 | -0.105 | 2 | 0.876 |
ATR |
0.822 | 0.024 | 1 | 0.852 |
DMPK1 |
0.822 | 0.048 | -3 | 0.822 |
EEF2K |
0.821 | -0.086 | 3 | 0.724 |
ALPHAK3 |
0.821 | -0.061 | -1 | 0.763 |
PRP4 |
0.821 | 0.065 | -3 | 0.725 |
OSR1 |
0.821 | -0.060 | 2 | 0.829 |
CAMKK1 |
0.821 | -0.108 | -2 | 0.762 |
ROCK2 |
0.820 | 0.069 | -3 | 0.837 |
HIPK4 |
0.820 | 0.325 | 1 | 0.900 |
CAMK1B |
0.820 | 0.004 | -3 | 0.895 |
SKMLCK |
0.819 | 0.121 | -2 | 0.854 |
MLK2 |
0.819 | 0.081 | 2 | 0.851 |
MST1 |
0.818 | -0.153 | 1 | 0.792 |
NEK11 |
0.818 | -0.098 | 1 | 0.796 |
MYO3B |
0.818 | -0.069 | 2 | 0.844 |
P38D |
0.817 | 0.177 | 1 | 0.709 |
DYRK2 |
0.817 | 0.203 | 1 | 0.834 |
ANKRD3 |
0.817 | -0.134 | 1 | 0.874 |
AAK1 |
0.817 | 0.067 | 1 | 0.699 |
MOK |
0.817 | 0.187 | 1 | 0.853 |
GRK7 |
0.816 | 0.174 | 1 | 0.768 |
NEK4 |
0.816 | -0.120 | 1 | 0.813 |
BUB1 |
0.815 | 0.140 | -5 | 0.803 |
MEKK1 |
0.815 | -0.135 | 1 | 0.838 |
ERK5 |
0.814 | 0.108 | 1 | 0.862 |
NEK8 |
0.814 | -0.135 | 2 | 0.842 |
DAPK3 |
0.814 | 0.008 | -3 | 0.850 |
YSK1 |
0.814 | -0.100 | 2 | 0.831 |
MYO3A |
0.813 | -0.113 | 1 | 0.805 |
YSK4 |
0.813 | -0.076 | 1 | 0.774 |
P38G |
0.813 | 0.151 | 1 | 0.683 |
CLK3 |
0.813 | 0.237 | 1 | 0.902 |
CDKL5 |
0.812 | 0.166 | -3 | 0.851 |
ALK2 |
0.812 | -0.041 | -2 | 0.793 |
TGFBR1 |
0.812 | 0.002 | -2 | 0.785 |
MEK2 |
0.812 | -0.191 | 2 | 0.841 |
SMMLCK |
0.811 | -0.036 | -3 | 0.863 |
STLK3 |
0.811 | -0.150 | 1 | 0.760 |
HIPK3 |
0.811 | 0.163 | 1 | 0.847 |
ERK1 |
0.811 | 0.169 | 1 | 0.752 |
MEKK3 |
0.811 | -0.146 | 1 | 0.812 |
LOK |
0.810 | -0.037 | -2 | 0.759 |
BMPR1B |
0.810 | 0.029 | 1 | 0.765 |
JNK1 |
0.810 | 0.130 | 1 | 0.736 |
ZAK |
0.809 | -0.108 | 1 | 0.793 |
CHAK2 |
0.809 | 0.070 | -1 | 0.855 |
HIPK2 |
0.809 | 0.253 | 1 | 0.763 |
ERK2 |
0.807 | 0.104 | 1 | 0.795 |
GRK5 |
0.807 | -0.014 | -3 | 0.882 |
DYRK1A |
0.807 | 0.169 | 1 | 0.859 |
PIM3 |
0.807 | 0.142 | -3 | 0.882 |
MASTL |
0.807 | -0.092 | -2 | 0.829 |
PERK |
0.806 | -0.097 | -2 | 0.822 |
CDK1 |
0.806 | 0.161 | 1 | 0.757 |
RAF1 |
0.806 | -0.113 | 1 | 0.841 |
HASPIN |
0.805 | 0.040 | -1 | 0.749 |
COT |
0.805 | 0.089 | 2 | 0.920 |
CDK5 |
0.805 | 0.154 | 1 | 0.821 |
ACVR2B |
0.804 | -0.038 | -2 | 0.778 |
TLK2 |
0.804 | -0.032 | 1 | 0.813 |
PIM1 |
0.804 | 0.092 | -3 | 0.848 |
SLK |
0.803 | -0.001 | -2 | 0.714 |
CDK14 |
0.803 | 0.139 | 1 | 0.784 |
PDHK4 |
0.802 | -0.156 | 1 | 0.873 |
CAMK2G |
0.802 | -0.053 | 2 | 0.848 |
ACVR2A |
0.802 | -0.057 | -2 | 0.765 |
WNK4 |
0.802 | -0.082 | -2 | 0.892 |
CDC7 |
0.802 | 0.066 | 1 | 0.831 |
WNK1 |
0.801 | -0.012 | -2 | 0.892 |
RIPK1 |
0.801 | -0.069 | 1 | 0.841 |
MLK1 |
0.801 | -0.069 | 2 | 0.837 |
GRK1 |
0.801 | 0.212 | -2 | 0.820 |
DAPK1 |
0.801 | -0.011 | -3 | 0.843 |
GRK6 |
0.801 | -0.040 | 1 | 0.829 |
IRAK4 |
0.800 | -0.039 | 1 | 0.839 |
ROCK1 |
0.800 | 0.017 | -3 | 0.808 |
CDK18 |
0.799 | 0.184 | 1 | 0.745 |
NEK9 |
0.798 | -0.106 | 2 | 0.866 |
PKN3 |
0.798 | 0.008 | -3 | 0.860 |
CDK7 |
0.797 | 0.170 | 1 | 0.805 |
AMPKA1 |
0.797 | 0.028 | -3 | 0.884 |
MLK3 |
0.797 | 0.044 | 2 | 0.767 |
DYRK1B |
0.797 | 0.140 | 1 | 0.789 |
DYRK4 |
0.797 | 0.183 | 1 | 0.766 |
SRPK1 |
0.797 | 0.155 | -3 | 0.821 |
RIPK3 |
0.796 | -0.054 | 3 | 0.668 |
DCAMKL1 |
0.796 | 0.022 | -3 | 0.830 |
PIM2 |
0.796 | 0.048 | -3 | 0.810 |
PDHK1 |
0.796 | -0.134 | 1 | 0.860 |
CRIK |
0.796 | 0.042 | -3 | 0.780 |
HRI |
0.795 | -0.189 | -2 | 0.834 |
MRCKA |
0.795 | 0.025 | -3 | 0.808 |
PKCD |
0.795 | 0.031 | 2 | 0.815 |
DYRK3 |
0.795 | 0.126 | 1 | 0.856 |
GSK3A |
0.795 | 0.076 | 4 | 0.457 |
MTOR |
0.795 | 0.001 | 1 | 0.830 |
CDK17 |
0.795 | 0.155 | 1 | 0.689 |
MRCKB |
0.795 | 0.029 | -3 | 0.801 |
PLK1 |
0.795 | -0.111 | -2 | 0.782 |
CLK4 |
0.794 | 0.096 | -3 | 0.825 |
GSK3B |
0.794 | 0.027 | 4 | 0.452 |
TAO1 |
0.794 | -0.113 | 1 | 0.740 |
TLK1 |
0.794 | -0.142 | -2 | 0.807 |
TSSK2 |
0.794 | -0.079 | -5 | 0.862 |
ERK7 |
0.794 | 0.045 | 2 | 0.561 |
CAMK2D |
0.793 | 0.032 | -3 | 0.867 |
BMPR1A |
0.793 | -0.024 | 1 | 0.746 |
SMG1 |
0.793 | -0.013 | 1 | 0.805 |
NEK2 |
0.793 | -0.098 | 2 | 0.839 |
P70S6KB |
0.792 | 0.021 | -3 | 0.845 |
PINK1 |
0.792 | -0.120 | 1 | 0.907 |
CDK4 |
0.791 | 0.106 | 1 | 0.748 |
CDK8 |
0.791 | 0.146 | 1 | 0.801 |
NUAK2 |
0.791 | 0.006 | -3 | 0.881 |
CDK6 |
0.791 | 0.096 | 1 | 0.770 |
SGK3 |
0.791 | 0.053 | -3 | 0.825 |
CDK3 |
0.791 | 0.142 | 1 | 0.708 |
DNAPK |
0.791 | -0.009 | 1 | 0.712 |
CDK16 |
0.790 | 0.142 | 1 | 0.711 |
PKN2 |
0.790 | -0.021 | -3 | 0.874 |
SRPK3 |
0.790 | 0.075 | -3 | 0.801 |
MLK4 |
0.790 | -0.045 | 2 | 0.748 |
DSTYK |
0.789 | -0.096 | 2 | 0.925 |
CHK1 |
0.788 | -0.070 | -3 | 0.837 |
TSSK1 |
0.788 | -0.018 | -3 | 0.893 |
AKT2 |
0.787 | 0.063 | -3 | 0.767 |
PKCZ |
0.787 | 0.039 | 2 | 0.811 |
NEK3 |
0.787 | -0.168 | 1 | 0.792 |
MARK4 |
0.787 | -0.016 | 4 | 0.813 |
MST4 |
0.787 | -0.033 | 2 | 0.868 |
RSK2 |
0.787 | 0.076 | -3 | 0.831 |
CDK10 |
0.787 | 0.135 | 1 | 0.772 |
AMPKA2 |
0.787 | 0.044 | -3 | 0.860 |
TGFBR2 |
0.787 | -0.038 | -2 | 0.769 |
CDK13 |
0.786 | 0.105 | 1 | 0.782 |
PAK1 |
0.786 | 0.029 | -2 | 0.784 |
GRK2 |
0.786 | -0.061 | -2 | 0.717 |
DCAMKL2 |
0.786 | -0.024 | -3 | 0.843 |
PKCA |
0.786 | 0.052 | 2 | 0.752 |
TBK1 |
0.785 | -0.044 | 1 | 0.740 |
CHAK1 |
0.785 | -0.097 | 2 | 0.815 |
DRAK1 |
0.785 | -0.074 | 1 | 0.735 |
P90RSK |
0.785 | 0.065 | -3 | 0.823 |
CDK2 |
0.784 | 0.030 | 1 | 0.822 |
CAMK2A |
0.784 | 0.088 | 2 | 0.836 |
MYLK4 |
0.784 | -0.014 | -2 | 0.746 |
CDK12 |
0.783 | 0.102 | 1 | 0.756 |
SGK1 |
0.783 | 0.069 | -3 | 0.700 |
PAK2 |
0.782 | -0.042 | -2 | 0.768 |
WNK3 |
0.782 | -0.156 | 1 | 0.840 |
HUNK |
0.782 | -0.149 | 2 | 0.857 |
CAMK2B |
0.782 | 0.037 | 2 | 0.825 |
ULK2 |
0.782 | -0.098 | 2 | 0.819 |
CLK1 |
0.781 | 0.096 | -3 | 0.804 |
IRE1 |
0.781 | -0.058 | 1 | 0.832 |
CDK9 |
0.781 | 0.092 | 1 | 0.788 |
NDR1 |
0.781 | 0.030 | -3 | 0.869 |
MAPKAPK3 |
0.781 | 0.021 | -3 | 0.820 |
CDK19 |
0.780 | 0.154 | 1 | 0.767 |
ATM |
0.780 | -0.050 | 1 | 0.780 |
NEK6 |
0.780 | -0.018 | -2 | 0.838 |
TTBK2 |
0.780 | -0.105 | 2 | 0.753 |
NEK7 |
0.780 | -0.152 | -3 | 0.830 |
NDR2 |
0.780 | 0.171 | -3 | 0.877 |
IKKB |
0.780 | -0.021 | -2 | 0.755 |
PLK3 |
0.780 | -0.104 | 2 | 0.817 |
MELK |
0.779 | -0.004 | -3 | 0.841 |
PRKD1 |
0.779 | 0.064 | -3 | 0.856 |
PAK3 |
0.779 | -0.006 | -2 | 0.776 |
IKKE |
0.778 | -0.067 | 1 | 0.731 |
PKCB |
0.778 | 0.024 | 2 | 0.762 |
PKCH |
0.778 | -0.023 | 2 | 0.745 |
IKKA |
0.777 | 0.065 | -2 | 0.750 |
RSK4 |
0.777 | 0.101 | -3 | 0.805 |
PDHK3_TYR |
0.777 | 0.150 | 4 | 0.868 |
CHK2 |
0.776 | 0.008 | -3 | 0.715 |
CK1D |
0.776 | 0.037 | -3 | 0.585 |
AURB |
0.776 | 0.010 | -2 | 0.622 |
PKACG |
0.776 | 0.032 | -2 | 0.717 |
IRAK1 |
0.776 | -0.222 | -1 | 0.755 |
GRK4 |
0.776 | -0.081 | -2 | 0.833 |
LATS2 |
0.776 | 0.077 | -5 | 0.796 |
AURC |
0.775 | 0.100 | -2 | 0.626 |
AKT1 |
0.775 | 0.037 | -3 | 0.778 |
CAMK4 |
0.775 | -0.087 | -3 | 0.858 |
SRPK2 |
0.775 | 0.150 | -3 | 0.755 |
PRKD3 |
0.775 | 0.016 | -3 | 0.806 |
IRE2 |
0.774 | -0.092 | 2 | 0.767 |
CAMK1D |
0.774 | -0.003 | -3 | 0.756 |
PKCG |
0.774 | 0.003 | 2 | 0.765 |
MSK1 |
0.774 | 0.049 | -3 | 0.813 |
PKG2 |
0.774 | 0.039 | -2 | 0.646 |
CLK2 |
0.773 | 0.144 | -3 | 0.811 |
PKCE |
0.773 | 0.008 | 2 | 0.746 |
SBK |
0.773 | 0.045 | -3 | 0.658 |
KIS |
0.772 | 0.188 | 1 | 0.822 |
RSK3 |
0.771 | 0.048 | -3 | 0.821 |
SSTK |
0.771 | -0.053 | 4 | 0.791 |
MNK2 |
0.771 | 0.052 | -2 | 0.767 |
MNK1 |
0.771 | 0.026 | -2 | 0.777 |
QIK |
0.771 | -0.095 | -3 | 0.867 |
STK33 |
0.771 | -0.097 | 2 | 0.660 |
PLK2 |
0.771 | -0.050 | -3 | 0.762 |
QSK |
0.770 | 0.006 | 4 | 0.789 |
PKACB |
0.770 | 0.074 | -2 | 0.638 |
NIM1 |
0.770 | -0.067 | 3 | 0.694 |
PRKD2 |
0.770 | 0.058 | -3 | 0.819 |
PDHK4_TYR |
0.769 | 0.064 | 2 | 0.916 |
MAP2K4_TYR |
0.769 | 0.040 | -1 | 0.865 |
MSK2 |
0.768 | 0.020 | -3 | 0.814 |
TESK1_TYR |
0.768 | 0.047 | 3 | 0.824 |
PKCI |
0.768 | -0.045 | 2 | 0.768 |
MARK2 |
0.768 | -0.055 | 4 | 0.717 |
MAPKAPK2 |
0.767 | 0.063 | -3 | 0.791 |
PKMYT1_TYR |
0.767 | 0.049 | 3 | 0.800 |
CAMK1G |
0.767 | -0.039 | -3 | 0.816 |
CK1A2 |
0.767 | 0.019 | -3 | 0.590 |
PLK4 |
0.767 | -0.066 | 2 | 0.661 |
MAP2K6_TYR |
0.767 | 0.025 | -1 | 0.865 |
RIPK2 |
0.765 | -0.233 | 1 | 0.746 |
PKCT |
0.765 | -0.020 | 2 | 0.755 |
LIMK2_TYR |
0.765 | 0.083 | -3 | 0.885 |
MARK3 |
0.764 | -0.018 | 4 | 0.747 |
PDHK1_TYR |
0.764 | -0.016 | -1 | 0.887 |
BMPR2_TYR |
0.764 | -0.010 | -1 | 0.861 |
CK1E |
0.764 | 0.037 | -3 | 0.631 |
ULK1 |
0.763 | -0.123 | -3 | 0.781 |
GCN2 |
0.763 | -0.147 | 2 | 0.831 |
BCKDK |
0.763 | -0.114 | -1 | 0.758 |
MAP2K7_TYR |
0.763 | -0.075 | 2 | 0.892 |
AURA |
0.762 | -0.017 | -2 | 0.589 |
MARK1 |
0.762 | -0.076 | 4 | 0.766 |
PHKG1 |
0.761 | -0.005 | -3 | 0.861 |
GRK3 |
0.760 | -0.050 | -2 | 0.672 |
P70S6K |
0.760 | -0.006 | -3 | 0.774 |
NUAK1 |
0.760 | -0.010 | -3 | 0.831 |
YANK3 |
0.759 | -0.016 | 2 | 0.446 |
AKT3 |
0.759 | 0.063 | -3 | 0.714 |
SIK |
0.759 | -0.001 | -3 | 0.815 |
CAMK1A |
0.758 | -0.004 | -3 | 0.733 |
PAK6 |
0.757 | 0.040 | -2 | 0.691 |
PINK1_TYR |
0.756 | -0.181 | 1 | 0.866 |
PKACA |
0.755 | 0.040 | -2 | 0.583 |
TTBK1 |
0.754 | -0.123 | 2 | 0.669 |
CK2A2 |
0.754 | 0.026 | 1 | 0.688 |
EPHB4 |
0.754 | 0.029 | -1 | 0.824 |
EPHA6 |
0.754 | 0.013 | -1 | 0.852 |
RET |
0.753 | -0.048 | 1 | 0.830 |
LIMK1_TYR |
0.752 | -0.089 | 2 | 0.881 |
ABL2 |
0.752 | 0.040 | -1 | 0.801 |
TNK2 |
0.752 | 0.040 | 3 | 0.697 |
FGR |
0.752 | -0.007 | 1 | 0.866 |
MAPKAPK5 |
0.751 | -0.051 | -3 | 0.773 |
BRSK2 |
0.751 | -0.008 | -3 | 0.847 |
PRKX |
0.750 | 0.088 | -3 | 0.756 |
TXK |
0.750 | 0.052 | 1 | 0.825 |
MST1R |
0.749 | -0.068 | 3 | 0.737 |
PKN1 |
0.749 | -0.023 | -3 | 0.786 |
ABL1 |
0.749 | 0.021 | -1 | 0.796 |
JAK2 |
0.749 | -0.070 | 1 | 0.825 |
CSF1R |
0.748 | -0.029 | 3 | 0.715 |
YANK2 |
0.747 | -0.041 | 2 | 0.460 |
YES1 |
0.747 | -0.023 | -1 | 0.869 |
CK2A1 |
0.746 | 0.015 | 1 | 0.663 |
SNRK |
0.746 | -0.155 | 2 | 0.705 |
TYRO3 |
0.746 | -0.072 | 3 | 0.715 |
BRSK1 |
0.746 | -0.003 | -3 | 0.837 |
TYK2 |
0.746 | -0.144 | 1 | 0.825 |
DDR1 |
0.746 | -0.106 | 4 | 0.810 |
LCK |
0.746 | 0.026 | -1 | 0.847 |
FAM20C |
0.745 | 0.024 | 2 | 0.645 |
ROS1 |
0.745 | -0.080 | 3 | 0.681 |
EPHA4 |
0.745 | -0.023 | 2 | 0.819 |
SRMS |
0.745 | -0.025 | 1 | 0.834 |
HCK |
0.744 | -0.029 | -1 | 0.842 |
BLK |
0.743 | 0.026 | -1 | 0.859 |
FER |
0.743 | -0.105 | 1 | 0.866 |
FYN |
0.742 | 0.038 | -1 | 0.840 |
ITK |
0.741 | -0.026 | -1 | 0.798 |
JAK3 |
0.741 | -0.098 | 1 | 0.801 |
EPHB1 |
0.741 | -0.047 | 1 | 0.824 |
TNK1 |
0.740 | 0.009 | 3 | 0.702 |
TNNI3K_TYR |
0.740 | -0.020 | 1 | 0.859 |
PAK5 |
0.740 | -0.008 | -2 | 0.628 |
EPHB2 |
0.739 | -0.039 | -1 | 0.806 |
EPHB3 |
0.739 | -0.058 | -1 | 0.805 |
MET |
0.739 | -0.050 | 3 | 0.720 |
KIT |
0.738 | -0.091 | 3 | 0.721 |
KDR |
0.737 | -0.072 | 3 | 0.677 |
FGFR2 |
0.736 | -0.107 | 3 | 0.735 |
JAK1 |
0.736 | -0.033 | 1 | 0.757 |
NEK10_TYR |
0.736 | -0.064 | 1 | 0.701 |
PHKG2 |
0.735 | -0.084 | -3 | 0.836 |
BMX |
0.735 | -0.028 | -1 | 0.728 |
INSRR |
0.734 | -0.144 | 3 | 0.668 |
MERTK |
0.732 | -0.066 | 3 | 0.715 |
TEK |
0.732 | -0.120 | 3 | 0.656 |
AXL |
0.732 | -0.110 | 3 | 0.708 |
EPHA7 |
0.732 | -0.033 | 2 | 0.821 |
FGFR1 |
0.732 | -0.111 | 3 | 0.698 |
PDGFRB |
0.732 | -0.148 | 3 | 0.718 |
PTK2B |
0.731 | -0.016 | -1 | 0.789 |
DDR2 |
0.731 | 0.010 | 3 | 0.670 |
FLT3 |
0.731 | -0.158 | 3 | 0.703 |
PAK4 |
0.731 | 0.000 | -2 | 0.629 |
LYN |
0.731 | -0.061 | 3 | 0.643 |
CK1G1 |
0.731 | -0.002 | -3 | 0.615 |
SRC |
0.731 | -0.023 | -1 | 0.837 |
EPHA3 |
0.730 | -0.086 | 2 | 0.791 |
PTK6 |
0.730 | -0.119 | -1 | 0.713 |
FLT1 |
0.730 | -0.108 | -1 | 0.805 |
BTK |
0.729 | -0.135 | -1 | 0.762 |
WEE1_TYR |
0.729 | -0.101 | -1 | 0.736 |
TEC |
0.728 | -0.093 | -1 | 0.751 |
ALK |
0.727 | -0.101 | 3 | 0.646 |
FRK |
0.727 | -0.077 | -1 | 0.849 |
PDGFRA |
0.727 | -0.171 | 3 | 0.714 |
LTK |
0.726 | -0.110 | 3 | 0.683 |
CK1G3 |
0.726 | -0.017 | -3 | 0.455 |
ERBB2 |
0.726 | -0.142 | 1 | 0.768 |
PKG1 |
0.725 | -0.016 | -2 | 0.560 |
FGFR3 |
0.725 | -0.119 | 3 | 0.702 |
EPHA1 |
0.725 | -0.089 | 3 | 0.688 |
PTK2 |
0.724 | -0.015 | -1 | 0.782 |
NTRK1 |
0.724 | -0.174 | -1 | 0.786 |
SYK |
0.723 | -0.015 | -1 | 0.765 |
MATK |
0.722 | -0.104 | -1 | 0.729 |
EPHA5 |
0.721 | -0.073 | 2 | 0.804 |
CSK |
0.721 | -0.099 | 2 | 0.819 |
EPHA8 |
0.721 | -0.078 | -1 | 0.798 |
NTRK3 |
0.720 | -0.121 | -1 | 0.736 |
EGFR |
0.720 | -0.076 | 1 | 0.679 |
FLT4 |
0.719 | -0.180 | 3 | 0.687 |
INSR |
0.718 | -0.151 | 3 | 0.645 |
NTRK2 |
0.717 | -0.190 | 3 | 0.676 |
FGFR4 |
0.717 | -0.096 | -1 | 0.752 |
EPHA2 |
0.712 | -0.075 | -1 | 0.751 |
ERBB4 |
0.710 | -0.055 | 1 | 0.684 |
ZAP70 |
0.708 | 0.011 | -1 | 0.685 |
CK1A |
0.706 | -0.001 | -3 | 0.499 |
CK1G2 |
0.704 | -0.017 | -3 | 0.541 |
MUSK |
0.701 | -0.135 | 1 | 0.663 |
IGF1R |
0.700 | -0.169 | 3 | 0.593 |
FES |
0.696 | -0.124 | -1 | 0.705 |