Motif 1004 (n=247)

Position-wise Probabilities
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uniprot genes site source protein function
K7EN88 hCG_2039718 T162 ochoa HCG2039718, isoform CRA_g None
O00159 MYO1C T739 ochoa Unconventional myosin-Ic (Myosin I beta) (MMI-beta) (MMIb) Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes. {ECO:0000269|PubMed:24636949}.; FUNCTION: [Isoform 3]: Involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation. {ECO:0000250|UniProtKB:Q9WTI7}.
O00257 CBX4 T437 psp E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2) E3 SUMO-protein ligase that catalyzes sumoylation of target proteins by promoting the transfer of SUMO from the E2 enzyme to the substrate (PubMed:12679040, PubMed:22825850). Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131 (PubMed:22825850). {ECO:0000269|PubMed:12679040, ECO:0000269|PubMed:22825850}.; FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:12167701, PubMed:19636380, PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167701, PubMed:19636380, PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). {ECO:0000250|UniProtKB:O55187, ECO:0000269|PubMed:12167701, ECO:0000269|PubMed:19636380, ECO:0000269|PubMed:21282530}.
O00750 PIK3C2B T90 ochoa Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PI3K-C2-beta) (PtdIns-3-kinase C2 subunit beta) (EC 2.7.1.137) (EC 2.7.1.154) (C2-PI3K) (Phosphoinositide 3-kinase-C2-beta) Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns (PubMed:10805725, PubMed:11533253, PubMed:9830063). Does not phosphorylate PtdIns(4,5)P2 (PubMed:9830063). May be involved in EGF and PDGF signaling cascades (PubMed:10805725). {ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11533253, ECO:0000269|PubMed:9830063}.
O14492 SH2B2 T337 ochoa SH2B adapter protein 2 (Adapter protein with pleckstrin homology and Src homology 2 domains) (SH2 and PH domain-containing adapter protein APS) Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3. {ECO:0000269|PubMed:10374881, ECO:0000269|PubMed:12400014, ECO:0000269|PubMed:15378031, ECO:0000269|PubMed:9989826}.
O14668 PRRG1 T161 ochoa Transmembrane gamma-carboxyglutamic acid protein 1 (Proline-rich gamma-carboxyglutamic acid protein 1) (Proline-rich Gla protein 1) None
O14686 KMT2D T2314 ochoa Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}.
O14745 NHERF1 T293 ochoa|psp Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1) Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa. {ECO:0000250, ECO:0000269|PubMed:10499588, ECO:0000269|PubMed:18784102, ECO:0000269|PubMed:9096337, ECO:0000269|PubMed:9430655}.
O15014 ZNF609 T619 ochoa Zinc finger protein 609 Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}.
O15085 ARHGEF11 T550 ochoa Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}.
O15151 MDM4 T347 ochoa Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4) Along with MDM2, contributes to TP53 regulation (PubMed:32300648). Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. {ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:32300648}.
O15231 ZNF185 T545 ochoa Zinc finger protein 185 (LIM domain protein ZNF185) (P1-A) May be involved in the regulation of cellular proliferation and/or differentiation.
O15409 FOXP2 T336 ochoa Forkhead box protein P2 (CAG repeat protein 44) (Trinucleotide repeat-containing gene 10 protein) Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language.
O43167 ZBTB24 T138 ochoa Zinc finger and BTB domain-containing protein 24 (Zinc finger protein 450) May be involved in BMP2-induced transcription. {ECO:0000250}.
O43464 HTRA2 T215 ochoa Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI) [Isoform 1]: Serine protease that shows proteolytic activity against a non-specific substrate beta-casein (PubMed:10873535). Promotes apoptosis by either relieving the inhibition of BIRC proteins on caspases, leading to an increase in caspase activity; or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism (PubMed:15200957). Cleaves BIRC6 and relieves its inhibition on CASP3, CASP7 and CASP9, but it is also prone to inhibition by BIRC6 (PubMed:36758104, PubMed:36758105). Cleaves THAP5 and promotes its degradation during apoptosis (PubMed:19502560). {ECO:0000269|PubMed:10873535, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:19502560, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758105}.; FUNCTION: [Isoform 2]: Seems to be proteolytically inactive. {ECO:0000269|PubMed:10995577}.
O60271 SPAG9 T1246 ochoa C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}.
O60292 SIPA1L3 T175 ochoa Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}.
O60353 FZD6 T661 ochoa Frizzled-6 (Fz-6) (hFz6) Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity). {ECO:0000250|UniProtKB:Q61089}.
O60583 CCNT2 T479 ochoa Cyclin-T2 (CycT2) Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II) (PubMed:15563843, PubMed:9499409). The activity of this complex is regulated by binding with 7SK snRNA (PubMed:11713533). Plays a role during muscle differentiation; P-TEFB complex interacts with MYOD1; this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes; this event correlates with hyperphosphorylation of the CTD domain of RNA pol II (By similarity). In addition, enhances MYOD1-dependent transcription through interaction with PKN1 (PubMed:16331689). Involved in early embryo development (By similarity). {ECO:0000250|UniProtKB:Q7TQK0, ECO:0000269|PubMed:11713533, ECO:0000269|PubMed:15563843, ECO:0000269|PubMed:16331689, ECO:0000269|PubMed:9499409}.; FUNCTION: (Microbial infection) Promotes transcriptional activation of early and late herpes simplex virus 1/HHV-1 promoters. {ECO:0000269|PubMed:21509660}.
O60716 CTNND1 T235 ochoa Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}.
O75044 SRGAP2 T429 ochoa SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34) Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex (PubMed:20810653, PubMed:27373832, PubMed:28333212). Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832). SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses (By similarity). Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation (PubMed:27373832). Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions (By similarity). In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia (PubMed:20810653, PubMed:21148482). {ECO:0000250|UniProtKB:Q91Z67, ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21148482, ECO:0000269|PubMed:22559944, ECO:0000269|PubMed:27373832, ECO:0000269|PubMed:28333212}.
O75376 NCOR1 T1386 ochoa Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}.
O94887 FARP2 T430 ochoa FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3) Functions as a guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). {ECO:0000250}.
O94906 PRPF6 T266 ochoa Pre-mRNA-processing factor 6 (Androgen receptor N-terminal domain-transactivating protein 1) (ANT-1) (PRP6 homolog) (U5 snRNP-associated 102 kDa protein) (U5-102 kDa protein) Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome (PubMed:20118938, PubMed:21549338, PubMed:28781166). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. {ECO:0000269|PubMed:12039962, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:21549338, ECO:0000269|PubMed:28781166}.
O95425 SVIL T552 ochoa Supervillin (Archvillin) (p205/p250) [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}.
O95436 SLC34A2 T58 ochoa Sodium-dependent phosphate transport protein 2B (Sodium-phosphate transport protein 2B) (Na(+)-dependent phosphate cotransporter 2B) (NaPi3b) (Sodium/phosphate cotransporter 2B) (Na(+)/Pi cotransporter 2B) (NaPi-2b) (Solute carrier family 34 member 2) Involved in actively transporting phosphate into cells via Na(+) cotransport. {ECO:0000269|PubMed:10329428}.
O95747 OXSR1 T430 ochoa Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress-responsive 1 protein) Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:16669787, PubMed:18270262, PubMed:21321328, PubMed:34289367). Specifically recognizes and binds proteins with a RFXV motif (PubMed:16669787, PubMed:17721439, PubMed:21321328). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:17721439). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (PubMed:16669787, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:16669787, PubMed:19665974, PubMed:21321328). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (PubMed:18270262). Also acts as a regulator of angiogenesis in endothelial cells downstream of WNK1 (PubMed:23386621, PubMed:25362046). Acts as an activator of inward rectifier potassium channels KCNJ2/Kir2.1 and KCNJ4/Kir2.3 downstream of WNK1: recognizes and binds the RXFXV/I variant motif on KCNJ2/Kir2.1 and KCNJ4/Kir2.3 and regulates their localization to the cell membrane without mediating their phosphorylation (PubMed:29581290). Phosphorylates RELL1, RELL2 and RELT (PubMed:16389068, PubMed:28688764). Phosphorylates PAK1 (PubMed:14707132). Phosphorylates PLSCR1 in the presence of RELT (PubMed:22052202). {ECO:0000269|PubMed:14707132, ECO:0000269|PubMed:16389068, ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:17721439, ECO:0000269|PubMed:18270262, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22052202, ECO:0000269|PubMed:23386621, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:28688764, ECO:0000269|PubMed:29581290, ECO:0000269|PubMed:34289367}.
P02671 FGA T279 ochoa Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain] Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}.
P04049 RAF1 T362 ochoa RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}.
P04406 GAPDH T246 ochoa|psp Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-) Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:11724794, PubMed:3170585). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:11724794, PubMed:3170585). Modulates the organization and assembly of the cytoskeleton (By similarity). Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (PubMed:23332158, PubMed:27387501). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis (By similarity). Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). {ECO:0000250|UniProtKB:P04797, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23332158, ECO:0000269|PubMed:27387501, ECO:0000269|PubMed:3170585}.
P05783 KRT18 T404 ochoa Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18) Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269|PubMed:15529338, ECO:0000269|PubMed:16424149, ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:7523419, ECO:0000269|PubMed:8522591, ECO:0000269|PubMed:9298992, ECO:0000269|PubMed:9524113}.
P06733 ENO1 T376 ochoa Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:1369209, PubMed:29775581). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:10802057, PubMed:12666133, PubMed:2005901, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209). {ECO:0000269|PubMed:10802057, ECO:0000269|PubMed:12666133, ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:2005901, ECO:0000269|PubMed:29775581}.; FUNCTION: [Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. {ECO:0000269|PubMed:10082554}.
P09104 ENO2 T376 ochoa Gamma-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 2) (Neural enolase) (Neuron-specific enolase) (NSE) Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity). {ECO:0000250}.
P0DJJ0 SRGAP2C T429 ochoa SLIT-ROBO Rho GTPase-activating protein 2C (SLIT-ROBO Rho GTPase activating protein 2 pseudogene 1) Human-specific protein that acts as a key modifier of cortical connectivity in the human brain (PubMed:22559944, PubMed:27373832, PubMed:34707291). Acts by inhibiting the functions of ancestral paralog SRGAP2/SRGAP2A, a postsynaptic protein that regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832). SRGAP2C is unstable but is able to heterodimerize with SRGAP2/SRGAP2A, thereby reducing SRGAP2/SRGAP2A levels through proteasome-dependent degradation (PubMed:27373832, PubMed:28333212, PubMed:31822692). Inhibition of SRGAP2/SRGAP2A by SRGAP2C leads to an increase in synaptic density and protracted synaptic maturation of both excitatory and inhibitory synapses (PubMed:27373832, PubMed:34707291). Modifies cortical circuit connectivity by increasing the number of local and long-range cortical inputs received by layer 2/3 pyramidal neurons (PubMed:34707291). Also able to increase the probability of sensory-evoked responses by layer 2/3 pyramidal neurons (PubMed:34707291). {ECO:0000269|PubMed:22559944, ECO:0000269|PubMed:27373832, ECO:0000269|PubMed:28333212, ECO:0000269|PubMed:31822692, ECO:0000269|PubMed:34707291}.
P0DMP2 SRGAP2B T428 ochoa SLIT-ROBO Rho GTPase-activating protein 2B (SLIT-ROBO Rho GTPase activating protein 2 pseudogene 2) May regulate cell migration and differentiation through interaction with and inhibition of SRGAP2 (PubMed:31822692). In contrast to SRGAP2C, it is not able to induce long-lasting changes in synaptic density throughout adulthood (PubMed:31822692). {ECO:0000269|PubMed:31822692, ECO:0000305|PubMed:22559944, ECO:0000305|PubMed:31822692}.
P0DPH7 TUBA3C T382 ochoa Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P0DPH8 TUBA3D T382 ochoa Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P10451 SPP1 T66 ochoa|psp Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}.
P10451 SPP1 T237 ochoa|psp Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}.
P13010 XRCC5 T697 ochoa X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488}.
P13929 ENO3 T19 ochoa Beta-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 3) (Muscle-specific enolase) (MSE) (Skeletal muscle enolase) Glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. Appears to have a function in striated muscle development and regeneration. {ECO:0000250|UniProtKB:P15429}.
P13929 ENO3 T376 ochoa Beta-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 3) (Muscle-specific enolase) (MSE) (Skeletal muscle enolase) Glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. Appears to have a function in striated muscle development and regeneration. {ECO:0000250|UniProtKB:P15429}.
P14618 PKM T60 ochoa Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:1854723, ECO:0000269|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250|UniProtKB:P52480, ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263}.
P15056 BRAF T470 ochoa|psp Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:36402789, ECO:0000305}.
P18031 PTPN1 T368 ochoa Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139, ECO:0000269|PubMed:22169477}.
P19447 ERCC3 T236 ochoa General transcription and DNA repair factor IIH helicase/translocase subunit XPB (TFIIH subunit XPB) (EC 5.6.2.4) (Basic transcription factor 2 89 kDa subunit) (BTF2 p89) (DNA 3'-5' helicase/translocase XPB) (DNA excision repair protein ERCC-3) (DNA repair protein complementing XP-B cells) (TFIIH basal transcription factor complex 89 kDa subunit) (TFIIH 89 kDa subunit) (TFIIH p89) (Xeroderma pigmentosum group B-complementing protein) ATP-dependent 3'-5' DNA helicase/translocase (PubMed:17466626, PubMed:27193682, PubMed:33902107, PubMed:8465201, PubMed:8663148). Binds dsDNA rather than ssDNA, unzipping it in a translocase rather than classical helicase activity (PubMed:27193682, PubMed:33902107). Component of the general transcription and DNA repair factor IIH (TFIIH) core complex (PubMed:10024882, PubMed:17466626, PubMed:8157004, PubMed:8465201). When complexed to CDK-activating kinase (CAK), involved in RNA transcription by RNA polymerase II. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening; it may wrap around the damaged DNA wedging it open, causing localized melting that allows XPD/ERCC2 helicase to anchor (PubMed:10024882, PubMed:17466626). In transcription, TFIIH has an essential role in transcription initiation (PubMed:30894545, PubMed:8157004). When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape (PubMed:8157004). The ATP-dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape (PubMed:10024882). In transcription pre-initiation complexes induces and propagates a DNA twist to open DNA (PubMed:27193682, PubMed:33902107). Also involved in transcription-coupled nucleotide excision repair (NER) of damaged DNA (PubMed:17466626, PubMed:2111438, PubMed:8157004). In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The structure of the TFIIH transcription complex differs from the NER-TFIIH complex; large movements by XPD/ERCC2 and XPB/ERCC3 are stabilized by XPA (PubMed:31253769, PubMed:33902107). XPA retains XPB/ERCC3 at the 5' end of a DNA bubble (mimicking DNA damage) (PubMed:31253769). {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:17466626, ECO:0000269|PubMed:30894545, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:33902107, ECO:0000269|PubMed:7724549, ECO:0000269|PubMed:8157004, ECO:0000269|PubMed:8663148, ECO:0000305|PubMed:8465201}.
P20336 RAB3A T193 ochoa Ras-related protein Rab-3A (EC 3.6.5.2) The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:2501306). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:2501306). RAB3A plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (PubMed:2501306). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By similarity). Stimulates insulin secretion through interaction with RIMS2 or RPH3AL effectors in pancreatic beta cells (By similarity). Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR) via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9 (PubMed:27325790). Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1 (PubMed:22248876, PubMed:30599141). Also plays a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT (By similarity). {ECO:0000250|UniProtKB:P63011, ECO:0000250|UniProtKB:P63012, ECO:0000269|PubMed:22248876, ECO:0000269|PubMed:2501306, ECO:0000269|PubMed:27325790, ECO:0000269|PubMed:30599141}.
P23142 FBLN1 T150 ochoa Fibulin-1 (FIBL-1) Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP. {ECO:0000269|PubMed:11792823, ECO:0000269|PubMed:9393974, ECO:0000269|PubMed:9466671}.
P23588 EIF4B T195 ochoa Eukaryotic translation initiation factor 4B (eIF-4B) Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
P25101 EDNRA T396 psp Endothelin-1 receptor (Endothelin receptor type A) (ET-A) (ETA-R) (hET-AR) Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.
P28290 ITPRID2 T275 ochoa Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) None
P28715 ERCC5 T387 ochoa DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein) Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:32522879, ECO:0000269|PubMed:32821917, ECO:0000269|PubMed:7651464, ECO:0000269|PubMed:8078765, ECO:0000269|PubMed:8090225, ECO:0000269|PubMed:8206890, ECO:0000269|PubMed:9927729}.
P29966 MARCKS T150 ochoa|psp Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (80K-L protein) (PKCSL) Membrane-associated protein that plays a role in the structural modulation of the actin cytoskeleton, chemotaxis, motility, cell adhesion, phagocytosis, and exocytosis through lipid sequestering and/or protein docking to membranes (PubMed:23704996, PubMed:36009319). Thus, exerts an influence on a plethora of physiological processes, such as embryonic development, tissue regeneration, neuronal plasticity, and inflammation. Sequesters phosphatidylinositol 4,5-bisphosphate (PIP2) at lipid rafts in the plasma membrane of quiescent cells, an action reversed by protein kinase C, ultimately inhibiting exocytosis (PubMed:23704996). During inflammation, promotes the migration and adhesion of inflammatory cells and the secretion of cytokines such as tumor necrosis factor (TNF), particularly in macrophages (PubMed:37949888). Plays an essential role in bacteria-induced intracellular reactive oxygen species (ROS) formation in the monocytic cell type. Participates in the regulation of neurite initiation and outgrowth by interacting with components of cellular machinery including CDC42 that regulates cell shape and process extension through modulation of the cytoskeleton (By similarity). Plays also a role in axon development by mediating docking and fusion of RAB10-positive vesicles with the plasma membrane (By similarity). {ECO:0000250|UniProtKB:P26645, ECO:0000250|UniProtKB:P30009, ECO:0000269|PubMed:23704996, ECO:0000269|PubMed:36009319, ECO:0000269|PubMed:37949888}.
P30622 CLIP1 T351 ochoa CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}.
P30622 CLIP1 T1308 ochoa CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}.
P31751 AKT2 T133 ochoa RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-2) (Protein kinase B beta) (PKB beta) (RAC protein kinase beta) (RAC-PK-beta) Serine/threonine kinase closely related to AKT1 and AKT3. All 3 enzymes, AKT1, AKT2 and AKT3, are collectively known as AKT kinase. AKT regulates many processes including metabolism, proliferation, cell survival, growth and angiogenesis, through the phosphorylation of a range of downstream substrates. Over 100 substrates have been reported so far, although for most of them, the precise AKT kinase catalyzing the reaction was not specified. AKT regulates glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT also regulates the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven. AKT also regulates cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and FOXO4 are phosphorylated on equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1. AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis. Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis. Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity. The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor 1 (IGF1). AKT mediates the antiapoptotic effects of IGF1. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. May be involved in the regulation of the placental development (PubMed:21432781, PubMed:21620960). In response to lysophosphatidic acid stimulation, inhibits the ciliogenesis cascade. In this context, phosphorylates WDR44, hence stabilizing its interaction with Rab11 and preventing the formation of the ciliogenic Rab11-FIP3-RAB3IP complex. Also phosphorylates RAB3IP/Rabin8, thus may affect RAB3IP guanine nucleotide exchange factor (GEF) activity toward Rab8, which is important for cilia growth (PubMed:31204173). Phosphorylates PKP1, facilitating its interaction with YWHAG and translocation to the nucleus, ultimately resulting in a reduction in keratinocyte intercellular adhesion (By similarity). Phosphorylation of PKP1 increases PKP1 protein stability, translocation to the cytoplasm away from desmosome plaques and PKP1-driven cap-dependent translation (PubMed:23444369). {ECO:0000250|UniProtKB:Q60823, ECO:0000269|PubMed:23444369, ECO:0000269|PubMed:31204173, ECO:0000303|PubMed:21432781, ECO:0000303|PubMed:21620960}.; FUNCTION: Several AKT2-specific substrates have been identified, including ANKRD2, C2CD5, CLK2 and PITX2. May play a role in myoblast differentiation. In this context, may act through PITX2 phosphorylation. Unphosphorylated PITX2 associates with an ELAVL1/HuR-containing complex, which stabilizes CCND1 cyclin mRNA, ensuring cell proliferation. Phosphorylation by AKT2 impairs this association, leading to CCND1 mRNA destabilization and progression towards differentiation (By similarity). Also involved in the negative regulation of myogenesis in response to stress conditions. In this context, acts by phosphorylating ANKRD2 (By similarity). May also be a key regulator of glucose uptake. Regulates insulin-stimulated glucose transport by the increase of glucose transporter GLUT4 translocation from intracellular stores to the plasma membrane. In this context, acts by phosphorylating C2CD5/CDP138 on 'Ser-197' in insulin-stimulated adipocytes (By similarity). Through the phosphorylation of CLK2 on 'Thr-343', involved in insulin-regulated suppression of hepatic gluconeogenesis (By similarity). {ECO:0000250|UniProtKB:Q60823}.
P34972 CNR2 T340 ochoa|psp Cannabinoid receptor 2 (CB-2) (CB2) (hCB2) (CX5) Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. {ECO:0000269|PubMed:10051546, ECO:0000269|PubMed:12663043, ECO:0000269|PubMed:12711605, ECO:0000269|PubMed:18692962}.
P38398 BRCA1 T1194 ochoa Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}.
P41091 EIF2S3 T21 ochoa Eukaryotic translation initiation factor 2 subunit 3 (EC 3.6.5.3) (Eukaryotic translation initiation factor 2 subunit gamma X) (eIF2-gamma X) (eIF2gX) Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:31836389). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC) (By similarity). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex (By similarity). In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). {ECO:0000250|UniProtKB:P05198, ECO:0000269|PubMed:31836389}.
P42566 EPS15 T609 ochoa Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}.
P42704 LRPPRC T1030 ochoa Leucine-rich PPR motif-containing protein, mitochondrial (130 kDa leucine-rich protein) (LRP 130) (GP130) May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. Positively modulates nuclear export of mRNAs containing the EIF4E sensitivity element (4ESE) by binding simultaneously to both EIF4E and the 4ESE and acting as a platform for assembly for the RNA export complex (PubMed:19262567, PubMed:28325843). Also binds to exportin XPO1/CRM1 to engage the nuclear pore and traffic the bound mRNAs to the cytoplasm (PubMed:28325843). May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity). Required for maintaining mitochondrial potential (PubMed:23822101). Suppresses the initiation of basal levels of autophagy and mitophagy by sustaining BCL2 levels (PubMed:23822101). {ECO:0000250, ECO:0000269|PubMed:11585913, ECO:0000269|PubMed:12832482, ECO:0000269|PubMed:15081402, ECO:0000269|PubMed:15139850, ECO:0000269|PubMed:15272088, ECO:0000269|PubMed:17050673, ECO:0000269|PubMed:19262567, ECO:0000269|PubMed:23822101, ECO:0000269|PubMed:28325843}.
P46100 ATRX T752 ochoa Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}.
P46821 MAP1B T1525 ochoa Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}.
P48730 CSNK1D T387 ochoa Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26) Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. Phosphorylates NEDD9/HEF1 (By similarity). EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate. {ECO:0000250|UniProtKB:Q9DC28, ECO:0000269|PubMed:10606744, ECO:0000269|PubMed:12270943, ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:16027726, ECO:0000269|PubMed:17562708, ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:19043076, ECO:0000269|PubMed:20041275, ECO:0000269|PubMed:20048001, ECO:0000269|PubMed:20407760, ECO:0000269|PubMed:20637175, ECO:0000269|PubMed:20696890, ECO:0000269|PubMed:20699359, ECO:0000269|PubMed:21084295, ECO:0000269|PubMed:21422228, ECO:0000269|PubMed:23636092}.
P49189 ALDH9A1 T236 ochoa 4-trimethylaminobutyraldehyde dehydrogenase (TMABA-DH) (TMABALDH) (EC 1.2.1.47) (Aldehyde dehydrogenase E3 isozyme) (Aldehyde dehydrogenase family 9 member A1) (EC 1.2.1.3) (Formaldehyde dehydrogenase) (EC 1.2.1.46) (Gamma-aminobutyraldehyde dehydrogenase) (EC 1.2.1.19) (R-aminobutyraldehyde dehydrogenase) [Cleaved into: 4-trimethylaminobutyraldehyde dehydrogenase, N-terminally processed] Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. Catalyzes the oxidation of aldehydes arising from biogenic amines and polyamines. {ECO:0000269|PubMed:10702312, ECO:0000269|PubMed:1799975, ECO:0000269|PubMed:30914451, ECO:0000269|PubMed:8645224}.
P49321 NASP T349 ochoa Nuclear autoantigenic sperm protein (NASP) Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.
P49790 NUP153 T222 ochoa Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}.
P49792 RANBP2 T1650 ochoa E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P49796 RGS3 T921 ochoa Regulator of G-protein signaling 3 (RGP3) (RGS3) Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases. {ECO:0000269|PubMed:10749886, ECO:0000269|PubMed:11294858, ECO:0000269|PubMed:8602223, ECO:0000269|PubMed:9858594}.
P52597 HNRNPF T35 ochoa Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed] Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. {ECO:0000269|PubMed:20526337}.
P54198 HIRA T554 ochoa Protein HIRA (TUP1-like enhancer of split protein 1) Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:0000269|PubMed:12370293, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527}.
P55198 MLLT6 T225 ochoa Protein AF-17 (ALL1-fused gene from chromosome 17 protein) None
P57060 RWDD2B T176 ochoa RWD domain-containing protein 2B None
P62879 GNB2 T31 ochoa Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (G protein subunit beta-2) (Transducin beta chain 2) Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
P68363 TUBA1B T382 ochoa Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}.
P68366 TUBA4A T382 ochoa Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P78337 PITX1 T53 ochoa Pituitary homeobox 1 (Hindlimb-expressed homeobox protein backfoot) (Homeobox protein PITX1) (Paired-like homeodomain transcription factor 1) Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb. {ECO:0000250|UniProtKB:P56673}.
P78527 PRKDC T4102 psp DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}.
P78559 MAP1A T1208 ochoa Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.
P81274 GPSM2 T486 ochoa G-protein-signaling modulator 2 (Mosaic protein LGN) Plays an important role in mitotic spindle pole organization via its interaction with NUMA1 (PubMed:11781568, PubMed:15632202, PubMed:21816348). Required for cortical dynein-dynactin complex recruitment during metaphase (PubMed:22327364). Plays a role in metaphase spindle orientation (PubMed:22327364). Also plays an important role in asymmetric cell divisions (PubMed:21816348). Has guanine nucleotide dissociation inhibitor (GDI) activity towards G(i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity (By similarity). {ECO:0000250|UniProtKB:Q8VDU0, ECO:0000269|PubMed:11781568, ECO:0000269|PubMed:15632202, ECO:0000269|PubMed:21816348, ECO:0000269|PubMed:22327364}.
P85299 PRR5 T287 ochoa Proline-rich protein 5 (Protein observed with Rictor-1) (Protor-1) Associated subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals (PubMed:17461779, PubMed:17599906, PubMed:29424687). mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive (PubMed:17461779, PubMed:17599906, PubMed:29424687). mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:17461779, PubMed:17599906, PubMed:29424687). PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling (PubMed:17599906). May act as a tumor suppressor in breast cancer (PubMed:15718101). {ECO:0000269|PubMed:15718101, ECO:0000269|PubMed:17461779, ECO:0000269|PubMed:17599906, ECO:0000269|PubMed:29424687}.
P98082 DAB2 T329 ochoa Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2) Adapter protein that functions as a clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor. {ECO:0000269|PubMed:11387212, ECO:0000269|PubMed:12805222, ECO:0000269|PubMed:16267015, ECO:0000269|PubMed:16984970, ECO:0000269|PubMed:19306879, ECO:0000269|PubMed:21995445, ECO:0000269|PubMed:22323290, ECO:0000269|PubMed:22491013}.
Q01826 SATB1 T188 psp DNA-binding protein SATB1 (Special AT-rich sequence-binding protein 1) Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis. Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone, possibly by positively regulating the expression of NEUROD1 (By similarity). {ECO:0000250|UniProtKB:Q60611, ECO:0000269|PubMed:10595394, ECO:0000269|PubMed:11463840, ECO:0000269|PubMed:12374985, ECO:0000269|PubMed:12692553, ECO:0000269|PubMed:1505028, ECO:0000269|PubMed:15618465, ECO:0000269|PubMed:15713622, ECO:0000269|PubMed:16377216, ECO:0000269|PubMed:16630892, ECO:0000269|PubMed:17173041, ECO:0000269|PubMed:17376900, ECO:0000269|PubMed:18337816, ECO:0000269|PubMed:19103759, ECO:0000269|PubMed:19247486, ECO:0000269|PubMed:19332023, ECO:0000269|PubMed:19430959, ECO:0000269|PubMed:33513338, ECO:0000269|PubMed:9111059, ECO:0000269|PubMed:9548713}.
Q01974 ROR2 T871 ochoa Tyrosine-protein kinase transmembrane receptor ROR2 (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development (By similarity). Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation (PubMed:17717073). In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443). {ECO:0000250|UniProtKB:Q9Z138, ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:25029443}.
Q03164 KMT2A T486 ochoa Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}.
Q12888 TP53BP1 T205 ochoa TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}.
Q12959 DLG1 T578 ochoa Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg) Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). May also play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (PubMed:23676497). {ECO:0000250|UniProtKB:A0A8C0TYJ0, ECO:0000250|UniProtKB:Q811D0, ECO:0000269|PubMed:10656683, ECO:0000269|PubMed:12445884, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15263016, ECO:0000269|PubMed:19213956, ECO:0000269|PubMed:20605917, ECO:0000269|PubMed:23676497}.
Q13286 CLN3 T19 ochoa Battenin (Batten disease protein) (Protein CLN3) Mediates microtubule-dependent, anterograde transport connecting the Golgi network, endosomes, autophagosomes, lysosomes and plasma membrane, and participates in several cellular processes such as regulation of lysosomal pH, lysosome protein degradation, receptor-mediated endocytosis, autophagy, transport of proteins and lipids from the TGN, apoptosis and synaptic transmission (PubMed:10924275, PubMed:15471887, PubMed:18317235, PubMed:18817525, PubMed:20850431, PubMed:22261744). Facilitates the proteins transport from trans-Golgi network (TGN)-to other membrane compartments such as transport of microdomain-associated proteins to the plasma membrane, IGF2R transport to the lysosome where it regulates the CTSD release leading to regulation of CTSD maturation and thereby APP intracellular processing (PubMed:10924275, PubMed:18817525). Moreover regulates CTSD activity in response to osmotic stress (PubMed:23840424, PubMed:28390177). Also binds galactosylceramide and transports it from the trans Golgi to the rafts, which may have immediate and downstream effects on cell survival by modulating ceramide synthesis (PubMed:18317235). At the plasma membrane, regulates actin-dependent events including filopodia formation, cell migration, and pinocytosis through ARF1-CDC42 pathway and also the cytoskeleton organization through interaction with MYH10 and fodrin leading to the regulation of the plasma membrane association of Na+, K+ ATPase complex (PubMed:20850431). Regulates synaptic transmission in the amygdala, hippocampus, and cerebellum through regulation of synaptic vesicles density and their proximity to active zones leading to modulation of short-term plasticity and age-dependent anxious behavior, learning and memory (By similarity). Regulates autophagic vacuoles (AVs) maturation by modulating the trafficking between endocytic and autophagolysosomal/lysosomal compartments, which involves vesicle fusion leading to regulation of degradation process (By similarity). Also participates in cellular homeostasis of compounds such as, water, ions, amino acids, proteins and lipids in several tissue namely in brain and kidney through regulation of their transport and synthesis (PubMed:17482562). {ECO:0000250|UniProtKB:Q61124, ECO:0000269|PubMed:10924275, ECO:0000269|PubMed:15471887, ECO:0000269|PubMed:17482562, ECO:0000269|PubMed:18317235, ECO:0000269|PubMed:18817525, ECO:0000269|PubMed:20850431, ECO:0000269|PubMed:22261744, ECO:0000269|PubMed:23840424, ECO:0000269|PubMed:28390177}.
Q13315 ATM T372 psp Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated) Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15064416, PubMed:15448695, PubMed:15456891, PubMed:15790808, PubMed:15916964, PubMed:17923702, PubMed:21757780, PubMed:24534091, PubMed:35076389, PubMed:9733514). Recognizes the substrate consensus sequence [ST]-Q (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15448695, PubMed:15456891, PubMed:15916964, PubMed:17923702, PubMed:24534091, PubMed:9733514). Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism (By similarity). Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FBXW7, FANCD2, NFKBIA, BRCA1, CREBBP/CBP, RBBP8/CTIP, FBXO46, MRE11, nibrin (NBN), RAD50, RAD17, PELI1, TERF1, UFL1, RAD9, UBQLN4 and DCLRE1C (PubMed:10550055, PubMed:10766245, PubMed:10802669, PubMed:10839545, PubMed:10910365, PubMed:10973490, PubMed:11375976, PubMed:12086603, PubMed:15456891, PubMed:19965871, PubMed:21757780, PubMed:24534091, PubMed:26240375, PubMed:26774286, PubMed:30171069, PubMed:30612738, PubMed:30886146, PubMed:30952868, PubMed:38128537, PubMed:9733515, PubMed:9843217). May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation (PubMed:19965871). Phosphorylates ATF2 which stimulates its function in DNA damage response (PubMed:15916964). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878). Phosphorylates TTC5/STRAP at 'Ser-203' in the cytoplasm in response to DNA damage, which promotes TTC5/STRAP nuclear localization (PubMed:15448695). Also involved in pexophagy by mediating phosphorylation of PEX5: translocated to peroxisomes in response to reactive oxygen species (ROS), and catalyzes phosphorylation of PEX5, promoting PEX5 ubiquitination and induction of pexophagy (PubMed:26344566). {ECO:0000250|UniProtKB:Q62388, ECO:0000269|PubMed:10550055, ECO:0000269|PubMed:10766245, ECO:0000269|PubMed:10802669, ECO:0000269|PubMed:10839545, ECO:0000269|PubMed:10910365, ECO:0000269|PubMed:10973490, ECO:0000269|PubMed:11375976, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12556884, ECO:0000269|PubMed:14871926, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15456891, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:16858402, ECO:0000269|PubMed:17923702, ECO:0000269|PubMed:19431188, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:21757780, ECO:0000269|PubMed:24534091, ECO:0000269|PubMed:26240375, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:30171069, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:30886146, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:35076389, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9733514, ECO:0000269|PubMed:9733515, ECO:0000269|PubMed:9843217}.
Q13495 MAMLD1 T681 ochoa Mastermind-like domain-containing protein 1 (F18) (Protein CG1) Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ. {ECO:0000269|PubMed:18162467}.
Q13554 CAMK2B T400 ochoa Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle (PubMed:16690701). In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). Phosphorylates reticulophagy regulator RETREG1 at 'Ser-151' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity (PubMed:31930741). {ECO:0000250|UniProtKB:P08413, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:29100089, ECO:0000269|PubMed:31930741}.
Q13873 BMPR2 T823 ochoa Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade (PubMed:12045205). Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. Promotes signaling also by binding to activin A/INHBA (PubMed:24018044). {ECO:0000250|UniProtKB:O35607, ECO:0000269|PubMed:12045205, ECO:0000269|PubMed:24018044}.
Q14451 GRB7 T371 ochoa Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein) Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity). {ECO:0000250, ECO:0000269|PubMed:10893408, ECO:0000269|PubMed:12021278, ECO:0000269|PubMed:12223469, ECO:0000269|PubMed:20622016}.
Q14571 ITPR2 T1017 ochoa Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 (IP3 receptor isoform 2) (IP3R 2) (InsP3R2) (Inositol 1,4,5-trisphosphate receptor type 2) (Type 2 inositol 1,4,5-trisphosphate receptor) (Type 2 InsP3 receptor) Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm. Exists in two states; a long-lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state into a 'drive' mode represented by periods of bursting activity (By similarity). {ECO:0000250|UniProtKB:Q9Z329}.
Q15042 RAB3GAP1 T542 ochoa Rab3 GTPase-activating protein catalytic subunit (RAB3 GTPase-activating protein 130 kDa subunit) (Rab3-GAP p130) (Rab3-GAP) Catalytic subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and guanine nucleotide exchange factor (GEF) activity towards RAB18 (PubMed:10859313, PubMed:24891604, PubMed:9030515). As part of the Rab3GAP complex, acts as a GAP for Rab3 proteins by converting active RAB3-GTP to the inactive form RAB3-GDP (PubMed:10859313). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones (PubMed:15696165). The Rab3GAP complex, acts as a GEF for RAB18 by promoting the conversion of inactive RAB18-GDP to the active form RAB18-GTP (PubMed:24891604). Recruits and stabilizes RAB18 at the cis-Golgi membrane in fibroblasts where RAB18 is most likely activated (PubMed:26063829). Also involved in RAB18 recruitment at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure (PubMed:24891604). Required for normal eye and brain development (PubMed:15696165, PubMed:23420520). May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (PubMed:9030515, PubMed:9852129). {ECO:0000269|PubMed:10859313, ECO:0000269|PubMed:15696165, ECO:0000269|PubMed:23420520, ECO:0000269|PubMed:24891604, ECO:0000269|PubMed:26063829, ECO:0000269|PubMed:9030515, ECO:0000269|PubMed:9852129}.
Q15149 PLEC T4411 ochoa Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}.
Q15424 SAFB T26 ochoa Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}.
Q15424 SAFB T200 ochoa Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}.
Q15424 SAFB T417 ochoa Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}.
Q15434 RBMS2 T40 ochoa RNA-binding motif, single-stranded-interacting protein 2 (Suppressor of CDC2 with RNA-binding motif 3) None
Q15788 NCOA1 T703 ochoa Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1) Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. {ECO:0000269|PubMed:10449719, ECO:0000269|PubMed:12954634, ECO:0000269|PubMed:7481822, ECO:0000269|PubMed:9223281, ECO:0000269|PubMed:9223431, ECO:0000269|PubMed:9296499, ECO:0000269|PubMed:9427757}.
Q16666 IFI16 T117 ochoa Gamma-interferon-inducible protein 16 (Ifi-16) (Interferon-inducible myeloid differentiation transcriptional activator) Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. {ECO:0000269|PubMed:11146555, ECO:0000269|PubMed:12894224, ECO:0000269|PubMed:14654789, ECO:0000269|PubMed:20890285, ECO:0000269|PubMed:21573174, ECO:0000269|PubMed:21575908, ECO:0000269|PubMed:22046441, ECO:0000269|PubMed:22291595, ECO:0000269|PubMed:23027953, ECO:0000269|PubMed:24198334, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:9642285}.; FUNCTION: [Isoform IFI16-beta]: Isoform that specifically inhibits the AIM2 inflammasome (PubMed:30104205). Binds double-stranded DNA (dsDNA) in the cytoplasm, impeding its detection by AIM2 (PubMed:30104205). Also prevents the interaction between AIM2 and PYCARD/ASC via its interaction with AIM2, thereby inhibiting assembly of the AIM2 inflammasome (PubMed:30104205). This isoform also weakly induce production of type I interferon-beta (IFNB1) via its interaction with STING1 (PubMed:30104205). {ECO:0000269|PubMed:30104205}.
Q2VIR3 EIF2S3B T21 ochoa Eukaryotic translation initiation factor 2 subunit 3B (EC 3.6.5.3) (Eukaryotic translation initiation factor 2 subunit gamma A) (eIF-2-gamma A) (eIF-2gA) Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). {ECO:0000250|UniProtKB:P05198}.
Q3KQU3 MAP7D1 T816 ochoa MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}.
Q4KWH8 PLCH1 T1499 ochoa 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-eta-1) (Phospholipase C-eta-1) (PLC-eta-1) (Phospholipase C-like protein 3) (PLC-L3) The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes. {ECO:0000269|PubMed:15702972}.
Q4LE39 ARID4B T1034 ochoa AT-rich interactive domain-containing protein 4B (ARID domain-containing protein 4B) (180 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p180) (Breast cancer-associated antigen BRCAA1) (Histone deacetylase complex subunit SAP180) (Retinoblastoma-binding protein 1-like 1) Acts as a transcriptional repressor (PubMed:12724404). May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:A2CG63, ECO:0000269|PubMed:12724404}.
Q5JR12 PPM1J T71 ochoa Protein phosphatase 1J (EC 3.1.3.16) (Protein phosphatase 2C isoform zeta) (PP2C-zeta) None
Q5JTV8 TOR1AIP1 T233 ochoa Torsin-1A-interacting protein 1 (Lamin-associated protein 1B) (LAP1B) Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina. {ECO:0000269|PubMed:23569223}.
Q5QJE6 DNTTIP2 T479 ochoa Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}.
Q5T5C0 STXBP5 T762 ochoa Syntaxin-binding protein 5 (Lethal(2) giant larvae protein homolog 3) (Tomosyn-1) Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding (By similarity). {ECO:0000250}.
Q5UIP0 RIF1 T1712 ochoa Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}.
Q5VWN6 TASOR2 T612 ochoa Protein TASOR 2 None
Q6GYQ0 RALGAPA1 T778 ochoa Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12) (GRIPE) (GTPase-activating Rap/Ran-GAP domain-like 1) (Tuberin-like protein 1) (p240) Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}.
Q6NUK4 REEP3 T157 ochoa Receptor expression-enhancing protein 3 Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes. {ECO:0000269|PubMed:23911198}.
Q6P2E9 EDC4 T588 ochoa Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}.
Q6WKZ4 RAB11FIP1 T1198 ochoa Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}.
Q6XZF7 DNMBP T1384 ochoa Dynamin-binding protein (Scaffold protein Tuba) Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:17015620, PubMed:19767742). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). {ECO:0000250|UniProtKB:E2RP94, ECO:0000250|UniProtKB:Q6TXD4, ECO:0000269|PubMed:17015620, ECO:0000269|PubMed:19767742, ECO:0000269|PubMed:20479467}.
Q70E73 RAPH1 T1017 ochoa Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion.
Q71U36 TUBA1A T382 ochoa Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q76FK4 NOL8 T381 ochoa Nucleolar protein 8 (Nucleolar protein Nop132) Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. {ECO:0000269|PubMed:14660641, ECO:0000269|PubMed:15132771, ECO:0000269|PubMed:16963496}.
Q7KZ85 SUPT6H T1530 ochoa Transcription elongation factor SPT6 (hSPT6) (Histone chaperone suppressor of Ty6) (Tat-cotransactivator 2 protein) (Tat-CT2 protein) Histone H3-H4 chaperone that plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A. {ECO:0000269|PubMed:15060154, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:22316138, ECO:0000269|PubMed:23503590, ECO:0000269|PubMed:9514752}.
Q7RTP6 MICAL3 T867 ochoa [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}.
Q7Z2W4 ZC3HAV1 T497 ochoa Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}.
Q7Z417 NUFIP2 T219 ochoa FMR1-interacting protein NUFIP2 (82 kDa FMRP-interacting protein) (82-FIP) (Cell proliferation-inducing gene 1 protein) (FMRP-interacting protein 2) (Nuclear FMR1-interacting protein 2) Binds RNA. {ECO:0000269|PubMed:12837692}.
Q7Z591 AKNA T539 ochoa Microtubule organization protein AKNA (AT-hook-containing transcription factor) Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}.
Q7Z6B0 CCDC91 T74 ochoa Coiled-coil domain-containing protein 91 (GGA-binding partner) (p56 accessory protein) Involved in the regulation of membrane traffic through the trans-Golgi network (TGN). Functions in close cooperation with the GGAs in the sorting of hydrolases to lysosomes. {ECO:0000269|PubMed:17596511}.
Q7Z6B7 SRGAP1 T945 ochoa SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. {ECO:0000269|PubMed:11672528}.
Q7Z6B7 SRGAP1 T1034 ochoa SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. {ECO:0000269|PubMed:11672528}.
Q7Z6E9 RBBP6 T701 ochoa E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}.
Q7Z6Z7 HUWE1 T2537 ochoa E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}.
Q86TJ2 TADA2B T149 ochoa Transcriptional adapter 2-beta (ADA2-like protein beta) (ADA2-beta) Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2. {ECO:0000269|PubMed:12972612}.
Q86VQ1 GLCCI1 T110 ochoa Glucocorticoid-induced transcript 1 protein None
Q86XJ1 GAS2L3 T575 ochoa GAS2-like protein 3 (Growth arrest-specific protein 2-like 3) Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network. {ECO:0000269|PubMed:21561867}.
Q8IUD2 ERC1 T1000 ochoa ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2) Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. {ECO:0000269|PubMed:15218148}.
Q8IVF2 AHNAK2 Y285 ochoa Protein AHNAK2 None
Q8N122 RPTOR T889 ochoa Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR)-scaffold protein) Component of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:32561715, PubMed:37541260). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating several substrates, such as ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:37541260). In the same time, it inhibits catabolic pathways by phosphorylating the autophagy initiation components ULK1 and ATG13, as well as transcription factor TFEB, a master regulators of lysosomal biogenesis and autophagy (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:32561715, PubMed:37541260). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:37541260). Within the mTORC1 complex, RPTOR acts both as a molecular adapter, which (1) mediates recruitment of mTORC1 to lysosomal membranes via interaction with small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD), and a (2) substrate-specific adapter, which promotes substrate specificity by binding to TOS motif-containing proteins and direct them towards the active site of the MTOR kinase domain for phosphorylation (PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:37541260). mTORC1 complex regulates many cellular processes, such as odontoblast and osteoclast differentiation or neuronal transmission (By similarity). mTORC1 complex in excitatory neuronal transmission is required for the prosocial behavior induced by the psychoactive substance lysergic acid diethylamide (LSD) (By similarity). {ECO:0000250|UniProtKB:Q8K4Q0, ECO:0000269|PubMed:12150925, ECO:0000269|PubMed:12150926, ECO:0000269|PubMed:12747827, ECO:0000269|PubMed:24403073, ECO:0000269|PubMed:26588989, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:37541260}.
Q8N1F7 NUP93 T85 ochoa Nuclear pore complex protein Nup93 (93 kDa nucleoporin) (Nucleoporin Nup93) Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (PubMed:26878725). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:15703211, ECO:0000269|PubMed:26878725, ECO:0000269|PubMed:9348540}.
Q8N488 RYBP T186 ochoa RING1 and YY1-binding protein (Apoptin-associating protein 1) (APAP-1) (Death effector domain-associated factor) (DED-associated factor) (YY1 and E4TF1-associated factor 1) Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (By similarity). Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes (PubMed:19098711). May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis (PubMed:14765135, PubMed:27060496). May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1 (PubMed:11953439). May bind to DNA (By similarity). May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3 (PubMed:27748911). {ECO:0000250|UniProtKB:Q8CCI5, ECO:0000269|PubMed:11953439, ECO:0000269|PubMed:14765135, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:27060496, ECO:0000269|PubMed:27748911}.
Q8N699 MYCT1 T143 ochoa Myc target protein 1 (Myc target in myeloid cells protein 1) May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does not seem to significantly affect growth cell capacity. Overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation (By similarity). {ECO:0000250}.
Q8N6S5 ARL6IP6 T32 ochoa ADP-ribosylation factor-like protein 6-interacting protein 6 (ARL-6-interacting protein 6) (Aip-6) (Phosphonoformate immuno-associated protein 1) None
Q8ND24 RNF214 T56 ochoa RING finger protein 214 None
Q8ND30 PPFIBP2 T481 ochoa Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2) May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. {ECO:0000269|PubMed:9624153}.
Q8NFC6 BOD1L1 T2848 ochoa Biorientation of chromosomes in cell division protein 1-like 1 Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}.
Q8NHV4 NEDD1 T401 ochoa|psp Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}.
Q8TDJ6 DMXL2 T1405 ochoa DmX-like protein 2 (Rabconnectin-3) May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles (PubMed:11809763). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity). {ECO:0000250|UniProtKB:Q8BPN8, ECO:0000269|PubMed:11809763}.
Q8WUM9 SLC20A1 T422 ochoa Sodium-dependent phosphate transporter 1 (Gibbon ape leukemia virus receptor 1) (GLVR-1) (Leukemia virus receptor 1 homolog) (Phosphate transporter 1) (PiT-1) (Solute carrier family 20 member 1) Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:11009570, PubMed:16790504, PubMed:17494632, PubMed:19726692, PubMed:7929240, PubMed:8041748). May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification (PubMed:11009570). Essential for cell proliferation but this function is independent of its phosphate transporter activity (PubMed:19726692). {ECO:0000269|PubMed:11009570, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:19726692, ECO:0000269|PubMed:7929240, ECO:0000269|PubMed:8041748}.; FUNCTION: (Microbial infection) May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV). {ECO:0000269|PubMed:12097582, ECO:0000269|PubMed:1309898, ECO:0000269|PubMed:2078500, ECO:0000269|PubMed:7966619}.
Q8WVD3 RNF138 T142 ochoa E3 ubiquitin-protein ligase RNF138 (EC 2.3.2.27) (Nemo-like kinase-associated RING finger protein) (NLK-associated RING finger protein) (hNARF) (RING finger protein 138) (RING-type E3 ubiquitin transferase RNF138) E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination (PubMed:26502055, PubMed:26502057). Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination (PubMed:26502055, PubMed:26502057). Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination (PubMed:26502055). According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP (PubMed:26502057). Together with NLK, involved in the ubiquitination and degradation of TCF/LEF (PubMed:16714285). Also exhibits auto-ubiquitination activity in combination with UBE2K (PubMed:16714285). May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway (PubMed:16714285). {ECO:0000269|PubMed:16714285, ECO:0000269|PubMed:26502055, ECO:0000269|PubMed:26502057}.
Q8WXH0 SYNE2 T4161 ochoa Nesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2) Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (PubMed:34818527). Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis. Facilitates the relaxation of mechanical stress imposed by compressive actin fibers at the rupture site through its nteraction with SYN2 (PubMed:34818527). {ECO:0000250|UniProtKB:Q6ZWQ0, ECO:0000269|PubMed:12118075, ECO:0000269|PubMed:18396275, ECO:0000269|PubMed:19596800, ECO:0000269|PubMed:20724637, ECO:0000269|PubMed:22945352, ECO:0000269|PubMed:34818527}.
Q8WXI7 MUC16 T12484 ochoa Mucin-16 (MUC-16) (Ovarian cancer-related tumor marker CA125) (CA-125) (Ovarian carcinoma antigen CA125) Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. {ECO:0000250}.
Q8WZ73 RFFL T245 ochoa E3 ubiquitin-protein ligase rififylin (EC 2.3.2.27) (Caspase regulator CARP2) (Caspases-8 and -10-associated RING finger protein 2) (CARP-2) (FYVE-RING finger protein Sakura) (Fring) (RING finger and FYVE-like domain-containing protein 1) (RING finger protein 189) (RING finger protein 34-like) (RING-type E3 ubiquitin transferase rififylin) E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling. {ECO:0000269|PubMed:15069192, ECO:0000269|PubMed:17121812, ECO:0000269|PubMed:18382127, ECO:0000269|PubMed:18450452, ECO:0000269|PubMed:22609986}.
Q92545 TMEM131 T1427 ochoa Transmembrane protein 131 (Protein RW1) Collagen binding transmembrane protein involved in collagen secretion by recruiting the ER-to-Golgi transport complex TRAPPIII (PubMed:32095531). May play a role in the immune response to viral infection. {ECO:0000250, ECO:0000269|PubMed:32095531}.
Q92698 RAD54L T41 ochoa DNA repair and recombination protein RAD54-like (EC 3.6.4.12) (RAD54 homolog) (hHR54) (hRAD54) Plays an essential role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks (PubMed:11459989, PubMed:12205100, PubMed:24798879, PubMed:27264870, PubMed:32457312, PubMed:9774452). Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism. Also plays an essential role in RAD51-mediated synaptic complex formation which consists of three strands encased in a protein filament formed once homology is recognized. Once DNA strand exchange occured, dissociates RAD51 from nucleoprotein filaments formed on dsDNA (By similarity). {ECO:0000250|UniProtKB:P32863, ECO:0000269|PubMed:11459989, ECO:0000269|PubMed:12205100, ECO:0000269|PubMed:24798879, ECO:0000269|PubMed:27264870, ECO:0000269|PubMed:32457312, ECO:0000269|PubMed:9774452}.
Q92870 APBB2 T232 ochoa Amyloid beta precursor protein binding family B member 2 (Amyloid-beta (A4) precursor protein-binding family B member 2) (Protein Fe65-like 1) Plays a role in the maintenance of lens transparency, and may also play a role in muscle cell strength (By similarity). Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning (By similarity). Activates transcription of APP (PubMed:14527950). {ECO:0000250|UniProtKB:Q9DBR4, ECO:0000269|PubMed:14527950}.
Q96D71 REPS1 T433 ochoa RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}.
Q96II8 LRCH3 T329 ochoa DISP complex protein LRCH3 (Leucine-rich repeat and calponin homology domain-containing protein 3) As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. {ECO:0000269|PubMed:29467281}.
Q96K49 TMEM87B T499 ochoa Transmembrane protein 87B May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN). {ECO:0000269|PubMed:26157166}.
Q96K76 USP47 T902 ochoa Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level. {ECO:0000269|PubMed:19966869, ECO:0000269|PubMed:21362556}.
Q96K76 USP47 T970 ochoa Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level. {ECO:0000269|PubMed:19966869, ECO:0000269|PubMed:21362556}.
Q96KG9 SCYL1 T748 ochoa N-terminal kinase-like protein (Coated vesicle-associated kinase of 90 kDa) (SCY1-like protein 1) (Telomerase regulation-associated protein) (Telomerase transcriptional element-interacting factor) (Teratoma-associated tyrosine kinase) Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum (PubMed:18556652). Involved in the maintenance of the Golgi apparatus morphology (PubMed:26581903). {ECO:0000269|PubMed:18556652, ECO:0000269|PubMed:26581903}.; FUNCTION: [Isoform 6]: Acts as a transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region. {ECO:0000269|PubMed:15963946}.
Q96PU5 NEDD4L T451 ochoa E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2) E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair (PubMed:20064473, PubMed:31959741, PubMed:33608556). Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation (PubMed:15496141). Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels (PubMed:28820317, PubMed:31959741). Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3 (PubMed:33608556). Ubiquitinates TTYH2 and TTYH3 and regulates protein levels of TTYH2 (PubMed:18577513). {ECO:0000250|UniProtKB:Q8CFI0, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15217910, ECO:0000269|PubMed:15489223, ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:15576372, ECO:0000269|PubMed:18577513, ECO:0000269|PubMed:19144635, ECO:0000269|PubMed:23999003, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:26363003, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27694961, ECO:0000269|PubMed:33608556}.
Q96QT6 PHF12 T136 ochoa PHD finger protein 12 (PHD factor 1) (Pf1) Transcriptional repressor acting as key scaffolding subunit of SIN3 complexes which contributes to complex assembly by contacting each core subunit domain, stabilizes the complex and constitutes the substrate receptor by recruiting the H3 histone tail (PubMed:37137925). SIN3 complexes are composed of a SIN3 scaffold subunit, one catalytic core (HDAC1 or HDAC2) and 2 chromatin targeting modules (PubMed:11390640, PubMed:37137925). SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:37137925). SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (PubMed:21041482). May also repress transcription in a SIN3A-independent manner through recruitment of functional TLE5 complexes to DNA (PubMed:11390640). May also play a role in ribosomal biogenesis (By similarity). {ECO:0000250|UniProtKB:Q5SPL2, ECO:0000269|PubMed:11390640, ECO:0000269|PubMed:21041482, ECO:0000269|PubMed:37137925}.
Q96S38 RPS6KC1 T647 ochoa Ribosomal protein S6 kinase delta-1 (S6K-delta-1) (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein) May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell (PubMed:12077123). Plays a role in the recruitment of PRDX3 to early endosomes (PubMed:15750338). {ECO:0000269|PubMed:12077123, ECO:0000269|PubMed:15750338}.
Q96SU4 OSBPL9 T322 ochoa Oxysterol-binding protein-related protein 9 (ORP-9) (OSBP-related protein 9) Interacts with OSBPL11 to function as lipid transfer proteins (PubMed:39106189). Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex (PubMed:39106189). {ECO:0000269|PubMed:39106189}.
Q96SU4 OSBPL9 T347 ochoa Oxysterol-binding protein-related protein 9 (ORP-9) (OSBP-related protein 9) Interacts with OSBPL11 to function as lipid transfer proteins (PubMed:39106189). Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex (PubMed:39106189). {ECO:0000269|PubMed:39106189}.
Q99460 PSMD1 T299 ochoa 26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1) (26S proteasome subunit p112) Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}.
Q99700 ATXN2 T672 ochoa Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}.
Q9BQQ3 GORASP1 T246 ochoa Golgi reassembly-stacking protein 1 (Golgi peripheral membrane protein p65) (Golgi phosphoprotein 5) (GOLPH5) (Golgi reassembly-stacking protein of 65 kDa) (GRASP65) Key structural protein of the Golgi apparatus (PubMed:33301566). The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (PubMed:33301566). Acting in concert with GORASP2/GRASP55, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (PubMed:33301566). However, other studies suggest that GORASP1 plays an important role in assembly and membrane stacking of the cisternae, and in the reassembly of Golgi stacks after breakdown during mitosis (By similarity). Caspase-mediated cleavage of GORASP1 is required for fragmentation of the Golgi during apoptosis (By similarity). Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (PubMed:16489344). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936). {ECO:0000250|UniProtKB:O35254, ECO:0000269|PubMed:16489344, ECO:0000269|PubMed:21884936, ECO:0000269|PubMed:33301566}.
Q9BRG2 SH2D3A T128 ochoa SH2 domain-containing protein 3A (Novel SH2-containing protein 1) May play a role in JNK activation.
Q9BXS6 NUSAP1 T67 ochoa Nucleolar and spindle-associated protein 1 (NuSAP) Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them. {ECO:0000250, ECO:0000269|PubMed:12963707}.
Q9BY89 KIAA1671 T1579 ochoa Uncharacterized protein KIAA1671 None
Q9BZQ8 NIBAN1 T584 ochoa Protein Niban 1 (Cell growth-inhibiting gene 39 protein) (Protein FAM129A) Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response (By similarity). {ECO:0000250}.
Q9C0C9 UBE2O T404 ochoa (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O) E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). {ECO:0000269|PubMed:23381138, ECO:0000269|PubMed:23452853, ECO:0000269|PubMed:23455153, ECO:0000269|PubMed:24703950}.
Q9C0H5 ARHGAP39 T256 ochoa Rho GTPase-activating protein 39 None
Q9C0H5 ARHGAP39 T692 ochoa Rho GTPase-activating protein 39 None
Q9H063 MAF1 T210 ochoa Repressor of RNA polymerase III transcription MAF1 homolog Plays a role in the repression of RNA polymerase III-mediated transcription in response to changing nutritional, environmental and cellular stress conditions to balance the production of highly abundant tRNAs, 5S rRNA, and other small non-coding RNAs with cell growth and maintenance (PubMed:18377933, PubMed:20233713, PubMed:20516213, PubMed:20543138). Also plays a key role in cell fate determination by promoting mesorderm induction and adipocyte differentiation (By similarity). Mechanistically, associates with the RNA polymerase III clamp and thereby impairs its recruitment to the complex made of the promoter DNA, TBP and the initiation factor TFIIIB (PubMed:17505538, PubMed:20887893). When nutrients are available and mTOR kinase is active, MAF1 is hyperphosphorylated and RNA polymerase III is engaged in transcription. Stress-induced MAF1 dephosphorylation results in nuclear localization, increased targeting of gene-bound RNA polymerase III and a decrease in the transcriptional readout (PubMed:26941251). Additionally, may also regulate RNA polymerase I and RNA polymerase II-dependent transcription through its ability to regulate expression of the central initiation factor TBP (PubMed:17499043). {ECO:0000250|UniProtKB:Q9D0U6, ECO:0000269|PubMed:17499043, ECO:0000269|PubMed:17505538, ECO:0000269|PubMed:18377933, ECO:0000269|PubMed:20233713, ECO:0000269|PubMed:20516213, ECO:0000269|PubMed:20543138, ECO:0000269|PubMed:20887893, ECO:0000269|PubMed:26941251}.
Q9H3Q1 CDC42EP4 T23 ochoa Cdc42 effector protein 4 (Binder of Rho GTPases 4) Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts.
Q9H814 PHAX T21 ochoa Phosphorylated adapter RNA export protein (RNA U small nuclear RNA export adapter protein) A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus (PubMed:39011894). Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Also plays a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Also binds to telomerase RNA. {ECO:0000250, ECO:0000269|PubMed:15574332, ECO:0000269|PubMed:15574333}.
Q9HAJ7 SAP30L T104 ochoa Histone deacetylase complex subunit SAP30L (HCV non-structural protein 4A-transactivated protein 2) (Sin3 corepressor complex subunit SAP30L) (Sin3-associated protein p30-like) [Isoform 1]: Functions as a transcription repressor, probably via its interaction with histone deacetylase complexes (PubMed:16820529, PubMed:18070604). Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus (PubMed:16820529). Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA (PubMed:19015240). Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import (PubMed:19015240, PubMed:26609676). {ECO:0000269|PubMed:16820529, ECO:0000269|PubMed:18070604, ECO:0000269|PubMed:19015240, ECO:0000269|PubMed:26609676}.; FUNCTION: [Isoform 2]: Functions as a transcription repressor; isoform 2 has lower transcription repressor activity than isoform 1 and isoform 3. {ECO:0000269|PubMed:18070604}.; FUNCTION: [Isoform 3]: Functions as a transcription repressor; its activity is marginally lower than that of isoform 1. {ECO:0000269|PubMed:18070604}.
Q9HC44 GPBP1L1 T301 ochoa Vasculin-like protein 1 (GC-rich promoter-binding protein 1-like 1) Possible transcription factor. {ECO:0000305}.
Q9HCK8 CHD8 T2051 ochoa Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:28533432, ECO:0000269|PubMed:36537238}.
Q9NPQ8 RIC8A T441 ochoa Chaperone Ric-8A (Synembryn-A) Chaperone that specifically binds and folds nascent G alpha proteins prior to G protein heterotrimer formation, promoting their stability and activity: folds GNAI1, GNAO1, GNA13 and GNAQ (By similarity). Does not fold G(s) G-alpha proteins GNAS nor GNAL (By similarity). Also acts as a guanine nucleotide exchange factor (GEF) for G alpha proteins by stimulating exchange of bound GDP for free GTP (By similarity). Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein (GNAI1), possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation (PubMed:16629901). {ECO:0000250|UniProtKB:Q80ZG1, ECO:0000269|PubMed:16629901}.
Q9NQ88 TIGAR T164 ochoa Fructose-2,6-bisphosphatase TIGAR (EC 3.1.3.46) (TP53-induced glycolysis and apoptosis regulator) (TP53-induced glycolysis regulatory phosphatase) Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate (PubMed:19015259). Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production (PubMed:16839880, PubMed:22887998). Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death (PubMed:16839880, PubMed:19713938, PubMed:22887998, PubMed:23726973, PubMed:23817040). Plays a role in promoting protection against cell death during hypoxia by decreasing mitochondria ROS levels in a HK2-dependent manner through a mechanism that is independent of its fructose-bisphosphatase activity (PubMed:23185017). In response to cardiac damage stress, mediates p53-induced inhibition of myocyte mitophagy through ROS levels reduction and the subsequent inactivation of BNIP3. Reduced mitophagy results in an enhanced apoptotic myocyte cell death, and exacerbates cardiac damage (By similarity). Plays a role in adult intestinal regeneration; contributes to the growth, proliferation and survival of intestinal crypts following tissue ablation (PubMed:23726973). Plays a neuroprotective role against ischemic brain damage by enhancing PPP flux and preserving mitochondria functions (By similarity). Protects glioma cells from hypoxia- and ROS-induced cell death by inhibiting glycolysis and activating mitochondrial energy metabolism and oxygen consumption in a TKTL1-dependent and p53/TP53-independent manner (PubMed:22887998). Plays a role in cancer cell survival by promoting DNA repair through activating PPP flux in a CDK5-ATM-dependent signaling pathway during hypoxia and/or genome stress-induced DNA damage responses (PubMed:25928429). Involved in intestinal tumor progression (PubMed:23726973). {ECO:0000250|UniProtKB:Q8BZA9, ECO:0000269|PubMed:16839880, ECO:0000269|PubMed:19015259, ECO:0000269|PubMed:19713938, ECO:0000269|PubMed:22887998, ECO:0000269|PubMed:23185017, ECO:0000269|PubMed:23726973, ECO:0000269|PubMed:23817040, ECO:0000269|PubMed:25928429}.
Q9NQG6 MIEF1 T97 ochoa Mitochondrial dynamics protein MIEF1 (Mitochondrial dynamics protein of 51 kDa) (Mitochondrial elongation factor 1) (Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like) (SMCR7-like protein) Mitochondrial outer membrane protein which regulates mitochondrial fission/fusion dynamics (PubMed:21701560, PubMed:23921378, PubMed:33632269). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L. {ECO:0000269|PubMed:21508961, ECO:0000269|PubMed:21701560, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:23921378, ECO:0000269|PubMed:24515348, ECO:0000269|PubMed:29083303, ECO:0000269|PubMed:33632269}.
Q9NR12 PDLIM7 T34 ochoa PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma) May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). {ECO:0000250, ECO:0000269|PubMed:11874232, ECO:0000269|PubMed:7929196}.
Q9NR48 ASH1L T1692 ochoa Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H) Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). {ECO:0000250|UniProtKB:Q99MY8, ECO:0000269|PubMed:21239497}.
Q9NRH2 SNRK T365 ochoa SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1-related kinase) May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis. {ECO:0000250|UniProtKB:Q63553, ECO:0000269|PubMed:12234663, ECO:0000269|PubMed:15733851}.
Q9NSY1 BMP2K T829 ochoa BMP-2-inducible protein kinase (BIKe) (EC 2.7.11.1) May be involved in osteoblast differentiation. {ECO:0000250|UniProtKB:Q91Z96}.
Q9NWB6 ARGLU1 T61 ochoa Arginine and glutamate-rich protein 1 Dual function regulator of gene expression; regulator of transcription and modulator of alternative splicing (PubMed:30698747). General coactivator of nuclear receptor-induced gene expression, including genes activated by the glucocorticoid receptor NR3C1 (PubMed:30698747). Binds to a subset of pre-mRNAs and to components of the spliceosome machinery to directly modulate basal alternative splicing; involved in simple and complex cassette exon splicing events (PubMed:30698747). Binds its own pre-mRNA and regulates its alternative splicing and degradation; one of the alternatively spliced products is a stable intronic sequence RNA (sisRNA) that binds the protein to regulate its ability to affect splicing (PubMed:27899669, PubMed:36533631). Binding of the sisRNA stimulates phase separation and localization to nuclear speckles, which may contribute to activation of nuclear receptor-induced gene expression (PubMed:36533631). May also indirectly modulate alternative splicing (PubMed:30698747). Regulates transcription of genes involved in heart development, neuronal cell function, protein localization and chromatin localization (By similarity). Regulates splicing of genes involved in neurogenesis and chromatin organization (By similarity). Essential for central nervous system development (By similarity). Required for the estrogen-dependent expression of ESR1 target genes (PubMed:21454576). Can act in cooperation with MED1 (PubMed:21454576). {ECO:0000250|UniProtKB:Q3UL36, ECO:0000269|PubMed:21454576, ECO:0000269|PubMed:27899669, ECO:0000269|PubMed:30698747, ECO:0000269|PubMed:36533631}.
Q9NWQ4 GPATCH2L T91 ochoa G patch domain-containing protein 2-like None
Q9NXR1 NDE1 T228 ochoa|psp Nuclear distribution protein nudE homolog 1 (NudE) Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a postmitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex. Acts as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network (PubMed:34793709). {ECO:0000269|PubMed:17600710, ECO:0000269|PubMed:21529752, ECO:0000269|PubMed:34793709}.
Q9NY65 TUBA8 T382 ochoa Tubulin alpha-8 chain (EC 3.6.5.-) (Alpha-tubulin 8) (Tubulin alpha chain-like 2) [Cleaved into: Dephenylalaninated tubulin alpha-8 chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q9NZ63 C9orf78 T106 ochoa Splicing factor C9orf78 (Hepatocellular carcinoma-associated antigen 59) Plays a role in pre-mRNA splicing by promoting usage of the upstream 3'-splice site at alternative NAGNAG splice sites; these are sites featuring alternative acceptor motifs separated by only a few nucleotides (PubMed:35241646). May also modulate exon inclusion events (PubMed:35241646). Plays a role in spliceosomal remodeling by displacing WBP4 from SNRNP200 and may act to inhibit SNRNP200 helicase activity (PubMed:35241646). Binds U5 snRNA (PubMed:35241646). Required for proper chromosome segregation (PubMed:35167828). Not required for splicing of shelterin components (PubMed:35167828). {ECO:0000269|PubMed:35167828, ECO:0000269|PubMed:35241646}.
Q9NZN8 CNOT2 T104 ochoa CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2) Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity. {ECO:0000269|PubMed:14707134, ECO:0000269|PubMed:16712523, ECO:0000269|PubMed:21299754, ECO:0000269|PubMed:22367759}.
Q9P2F8 SIPA1L2 T165 ochoa Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) None
Q9UBF8 PI4KB T280 ochoa Phosphatidylinositol 4-kinase beta (PI4K-beta) (PI4Kbeta) (PtdIns 4-kinase beta) (EC 2.7.1.67) (NPIK) (PI4K92) (PI4KIII) Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity) (PubMed:10559940, PubMed:11277933, PubMed:12749687, PubMed:9405935). May play an important role in the inner ear development. {ECO:0000250|UniProtKB:O08561, ECO:0000269|PubMed:10559940, ECO:0000269|PubMed:11277933, ECO:0000269|PubMed:12749687, ECO:0000269|PubMed:33358777, ECO:0000269|PubMed:9405935}.; FUNCTION: (Microbial infection) Plays an essential role in Aichi virus RNA replication (PubMed:22124328, PubMed:22258260, PubMed:27989622). Recruited by ACBD3 at the viral replication sites (PubMed:22124328, PubMed:27989622). {ECO:0000269|PubMed:22124328, ECO:0000269|PubMed:22258260, ECO:0000269|PubMed:27989622}.; FUNCTION: (Microbial infection) Required for cellular spike-mediated entry of human coronavirus SARS-CoV. {ECO:0000269|PubMed:22253445}.
Q9UBG0 MRC2 T1460 ochoa C-type mannose receptor 2 (C-type lectin domain family 13 member E) (Endocytic receptor 180) (Macrophage mannose receptor 2) (Urokinase-type plasminogen activator receptor-associated protein) (UPAR-associated protein) (Urokinase receptor-associated protein) (CD antigen CD280) May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs). {ECO:0000269|PubMed:10683150, ECO:0000269|PubMed:12972549}.
Q9UDT6 CLIP2 T355 ochoa CAP-Gly domain-containing linker protein 2 (Cytoplasmic linker protein 115) (CLIP-115) (Cytoplasmic linker protein 2) (Williams-Beuren syndrome chromosomal region 3 protein) (Williams-Beuren syndrome chromosomal region 4 protein) Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity). {ECO:0000250}.
Q9UJY4 GGA2 T287 ochoa ADP-ribosylation factor-binding protein GGA2 (Gamma-adaptin-related protein 2) (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear) Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:10747088). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15615712). {ECO:0000269|PubMed:10747088, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:27901063}.
Q9UK59 DBR1 T482 ochoa Lariat debranching enzyme (EC 3.1.4.-) Cleaves the 2'-5' phosphodiester linkage at the branch point of excised lariat intron RNA and converts them into linear molecules that can be subsequently degraded, thereby facilitating ribonucleotide turnover (PubMed:10982890, PubMed:16232320, PubMed:2435736). Linked to its role in pre-mRNA processing mechanism, may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis and have an antiviral cell-intrinsic defense function in the brainstem (PubMed:16232320, PubMed:29474921). {ECO:0000269|PubMed:10982890, ECO:0000269|PubMed:16232320, ECO:0000269|PubMed:2435736, ECO:0000269|PubMed:29474921}.
Q9UKY1 ZHX1 T546 ochoa Zinc fingers and homeoboxes protein 1 Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins. {ECO:0000269|PubMed:12237128}.
Q9ULH0 KIDINS220 T890 ochoa Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}.
Q9ULJ3 ZBTB21 T416 ochoa Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) Acts as a transcription repressor. {ECO:0000269|PubMed:15629158}.
Q9ULT8 HECTD1 T1723 ochoa E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:33711283). Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion (By similarity). Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure (By similarity). Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal (PubMed:33711283). {ECO:0000250|UniProtKB:Q69ZR2, ECO:0000269|PubMed:33711283}.
Q9UMD9 COL17A1 T387 ochoa Collagen alpha-1(XVII) chain (180 kDa bullous pemphigoid antigen 2) (Bullous pemphigoid antigen 2) [Cleaved into: 120 kDa linear IgA disease antigen (120 kDa linear IgA dermatosis antigen) (Linear IgA disease antigen 1) (LAD-1); 97 kDa linear IgA disease antigen (97 kDa linear IgA bullous dermatosis antigen) (97 kDa LAD antigen) (97-LAD) (Linear IgA bullous disease antigen of 97 kDa) (LABD97)] May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.; FUNCTION: The 120 kDa linear IgA disease antigen is an anchoring filament component involved in dermal-epidermal cohesion. Is the target of linear IgA bullous dermatosis autoantibodies.
Q9UMN6 KMT2B T1895 ochoa Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}.
Q9UPU9 SAMD4A T583 ochoa Protein Smaug homolog 1 (Smaug 1) (hSmaug1) (Sterile alpha motif domain-containing protein 4A) (SAM domain-containing protein 4A) Acts as a translational repressor of SRE-containing messengers. {ECO:0000269|PubMed:16221671}.
Q9UQ35 SRRM2 T1106 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9UQ35 SRRM2 T1147 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9UQC2 GAB2 T408 ochoa GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100) Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. {ECO:0000269|PubMed:15750601, ECO:0000269|PubMed:19172738}.
Q9UQM7 CAMK2A T336 ochoa Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17) Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation (PubMed:14722083). Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023). In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (PubMed:35568036). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity). {ECO:0000250|UniProtKB:P11275, ECO:0000250|UniProtKB:P11798, ECO:0000269|PubMed:11972023, ECO:0000269|PubMed:23805378, ECO:0000269|PubMed:28130356, ECO:0000269|PubMed:29100089}.
Q9Y286 SIGLEC7 T411 ochoa Sialic acid-binding Ig-like lectin 7 (Siglec-7) (Adhesion inhibitory receptor molecule 1) (AIRM-1) (CDw328) (D-siglec) (QA79 membrane protein) (p75) (CD antigen CD328) Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro). {ECO:0000269|PubMed:10611343}.
Q9Y2I7 PIKFYVE T28 ochoa 1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) (Serine-protein kinase PIKFYVE) (EC 2.7.11.1) Dual specificity kinase implicated in myriad essential cellular processes such as maintenance of endomembrane homeostasis, and endocytic-vacuolar pathway, lysosomal trafficking, nuclear transport, stress- or hormone-induced signaling and cell cycle progression (PubMed:23086417). The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Sole enzyme to catalyze the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form (PtdIns(3,5)P2) (PubMed:17556371). Also catalyzes the phosphorylation of phosphatidylinositol on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:22621786). Has serine-protein kinase activity and is able to autophosphorylate and transphosphorylate. Autophosphorylation inhibits its own phosphatidylinositol 3-phosphate 5-kinase activity, stimulates FIG4 lipid phosphatase activity and down-regulates lipid product formation (PubMed:33098764). Involved in key endosome operations such as fission and fusion in the course of endosomal cargo transport (PubMed:22621786). Required for the maturation of early into late endosomes, phagosomes and lysosomes (PubMed:30612035). Regulates vacuole maturation and nutrient recovery following engulfment of macromolecules, initiates the redistribution of accumulated lysosomal contents back into the endosome network (PubMed:27623384). Critical regulator of the morphology, degradative activity, and protein turnover of the endolysosomal system in macrophages and platelets (By similarity). In neutrophils, critical to perform chemotaxis, generate ROS, and undertake phagosome fusion with lysosomes (PubMed:28779020). Plays a key role in the processing and presentation of antigens by major histocompatibility complex class II (MHC class II) mediated by CTSS (PubMed:30612035). Regulates melanosome biogenesis by controlling the delivery of proteins from the endosomal compartment to the melanosome (PubMed:29584722). Essential for systemic glucose homeostasis, mediates insulin-induced signals for endosome/actin remodeling in the course of GLUT4 translocation/glucose uptake activation (By similarity). Supports microtubule-based endosome-to-trans-Golgi network cargo transport, through association with SPAG9 and RABEPK (By similarity). Mediates EGFR trafficking to the nucleus (PubMed:17909029). {ECO:0000250|UniProtKB:Q9Z1T6, ECO:0000269|PubMed:17556371, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:22621786, ECO:0000269|PubMed:27623384, ECO:0000269|PubMed:28779020, ECO:0000269|PubMed:29584722, ECO:0000269|PubMed:30612035, ECO:0000269|PubMed:33098764, ECO:0000303|PubMed:23086417}.; FUNCTION: (Microbial infection) Required for cell entry of coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus EMC (HCoV-EMC) by endocytosis. {ECO:0000269|PubMed:32221306}.
Q9Y2S7 POLDIP2 T295 ochoa Polymerase delta-interacting protein 2 (38 kDa DNA polymerase delta interaction protein) (p38) Involved in DNA damage tolerance by regulating translesion synthesis (TLS) of templates carrying DNA damage lesions such as 8oxoG and abasic sites (PubMed:24191025). May act by stimulating activity of DNA polymerases involved in TLS, such as PRIMPOL and polymerase delta (POLD1) (PubMed:24191025, PubMed:26984527). {ECO:0000269|PubMed:24191025, ECO:0000269|PubMed:26984527}.
Q9Y2X7 GIT1 T364 ochoa ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1) GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (By similarity). Through PAK1 activation, positively regulates microtubule nucleation during interphase (PubMed:27012601). Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (PubMed:23108400). May promote cell motility both by regulating focal complex dynamics and by local activation of RAC1 (PubMed:10938112, PubMed:11896197). May act as scaffold for MAPK1/3 signal transduction in focal adhesions. Recruits MAPK1/3/ERK1/2 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (PubMed:15923189). Plays a role in brain development and function. Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning (By similarity). Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed:12695502, PubMed:15800193). In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane. These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed:12695502). May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 (By similarity). In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane (By similarity). In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization (PubMed:25284783). May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input (By similarity). Required for successful bone regeneration during fracture healing (By similarity). The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis (By similarity). May play a role in angiogenesis during fracture healing (By similarity). In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and 'Lys-63'-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors (PubMed:31502302). Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis (PubMed:19273721). {ECO:0000250|UniProtKB:Q68FF6, ECO:0000250|UniProtKB:Q9Z272, ECO:0000269|PubMed:10938112, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12695502, ECO:0000269|PubMed:15800193, ECO:0000269|PubMed:15923189, ECO:0000269|PubMed:19273721, ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:25284783, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:31502302}.
Q9Y2Z0 SUGT1 T284 ochoa Protein SGT1 homolog (Protein 40-6-3) (Sgt1) (Suppressor of G2 allele of SKP1 homolog) May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.
Q9Y3P9 RABGAP1 T47 ochoa Rab GTPase-activating protein 1 (GAP and centrosome-associated protein) (Rab6 GTPase-activating protein GAPCenA) May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition. {ECO:0000269|PubMed:10202141, ECO:0000269|PubMed:16395330}.
Q9Y4A5 TRRAP T1633 ochoa Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog) Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. May play a role in the formation and maintenance of the auditory system (By similarity). {ECO:0000250|UniProtKB:A0A0R4ITC5, ECO:0000269|PubMed:11418595, ECO:0000269|PubMed:12138177, ECO:0000269|PubMed:12660246, ECO:0000269|PubMed:12743606, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:17967892, ECO:0000269|PubMed:24463511, ECO:0000269|PubMed:9708738}.
Q9Y4B5 MTCL1 T1749 ochoa Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}.
Q9Y4B5 MTCL1 T1757 ochoa Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}.
Q9Y520 PRRC2C T2191 ochoa Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}.
Q9Y6D5 ARFGEF2 T281 ochoa Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2) Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. {ECO:0000269|PubMed:12051703, ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15385626, ECO:0000269|PubMed:16477018, ECO:0000269|PubMed:17276987, ECO:0000269|PubMed:18625701, ECO:0000269|PubMed:20360857}.
R4GMW8 BIVM-ERCC5 T841 ochoa DNA excision repair protein ERCC-5 None
P14625 HSP90B1 T519 Sugiyama Endoplasmin (EC 3.6.4.-) (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog) ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport (PubMed:23572575, PubMed:39509507). Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway (PubMed:23572575, PubMed:39509507). When associated with CNPY3, required for proper folding of Toll-like receptors (PubMed:11584270). Promotes folding and trafficking of TLR4 to the cell surface (PubMed:11584270). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:11584270, ECO:0000269|PubMed:23572575, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:39509507}.
P38646 HSPA9 T94 Sugiyama Stress-70 protein, mitochondrial (EC 3.6.4.10) (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Heat shock protein family A member 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74) Mitochondrial chaperone that plays a key role in mitochondrial protein import, folding, and assembly. Plays an essential role in the protein quality control system, the correct folding of proteins, the re-folding of misfolded proteins, and the targeting of proteins for subsequent degradation. These processes are achieved through cycles of ATP binding, ATP hydrolysis, and ADP release, mediated by co-chaperones (PubMed:18632665, PubMed:25615450, PubMed:28848044, PubMed:30933555, PubMed:31177526). In mitochondria, it associates with the TIM (translocase of the inner membrane) protein complex to assist in the import and folding of mitochondrial proteins (By similarity). Plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis, interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:26702583). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823, PubMed:26702583). Regulates mitochondrial calcium-dependent apoptosis by coupling two calcium channels, ITPR1 and VDAC1, at the mitochondria-associated endoplasmic reticulum (ER) membrane to facilitate calcium transport from the ER lumen to the mitochondria intermembrane space, providing calcium for the downstream calcium channel MCU, which releases it into the mitochondrial matrix (By similarity). Although primarily located in the mitochondria, it is also found in other cellular compartments. In the cytosol, it associates with proteins involved in signaling, apoptosis, or senescence. It may play a role in cell cycle regulation via its interaction with and promotion of degradation of TP53 (PubMed:24625977, PubMed:26634371). May play a role in the control of cell proliferation and cellular aging (By similarity). Protects against reactive oxygen species (ROS) (By similarity). Extracellular HSPA9 plays a cytoprotective role by preventing cell lysis following immune attack by the membrane attack complex by disrupting formation of the complex (PubMed:16091382). {ECO:0000250|UniProtKB:P0CS90, ECO:0000250|UniProtKB:P38647, ECO:0000269|PubMed:16091382, ECO:0000269|PubMed:18632665, ECO:0000269|PubMed:21123823, ECO:0000269|PubMed:24625977, ECO:0000269|PubMed:25615450, ECO:0000269|PubMed:26634371, ECO:0000269|PubMed:26702583, ECO:0000269|PubMed:28848044, ECO:0000269|PubMed:30933555, ECO:0000269|PubMed:31177526}.
P62917 RPL8 T143 Sugiyama Large ribosomal subunit protein uL2 (60S ribosomal protein L8) Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}.
Q6UXH1 CRELD2 T300 Sugiyama Protein disulfide isomerase CRELD2 (EC 5.3.4.1) (Cysteine-rich with EGF-like domain protein 2) Protein disulfide isomerase (By similarity). Might play a role in the unfolded protein response (By similarity). May regulate transport of alpha4-beta2 neuronal acetylcholine receptor (PubMed:16238698). {ECO:0000250|UniProtKB:Q9CYA0, ECO:0000269|PubMed:16238698}.
Q15293 RCN1 T163 Sugiyama Reticulocalbin-1 May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment.
P04406 GAPDH T103 Sugiyama Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-) Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:11724794, PubMed:3170585). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:11724794, PubMed:3170585). Modulates the organization and assembly of the cytoskeleton (By similarity). Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (PubMed:23332158, PubMed:27387501). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis (By similarity). Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). {ECO:0000250|UniProtKB:P04797, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23332158, ECO:0000269|PubMed:27387501, ECO:0000269|PubMed:3170585}.
P13639 EEF2 T735 Sugiyama Elongation factor 2 (EF-2) (EC 3.6.5.-) Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:26593721). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721). {ECO:0000269|PubMed:26593721}.
P04040 CAT T125 Sugiyama Catalase (EC 1.11.1.6) Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide (PubMed:7882369). Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells (PubMed:7882369). {ECO:0000269|PubMed:7882369}.
P78406 RAE1 T77 Sugiyama mRNA export factor RAE1 (Rae1 protein homolog) (mRNA-associated protein mrnp 41) Acts as a mRNA export factor involved in nucleocytoplasmic transport (PubMed:20498086, PubMed:33849972). Plays a role in mitotic bipolar spindle formation (PubMed:17172455). May function in attaching cytoplasmic mRNPs to the cytoskeleton both directly or indirectly (PubMed:17172455). {ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:20498086, ECO:0000269|PubMed:33849972}.
P54750 PDE1A Y490 Sugiyama Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Cam-PDE 1A) (EC 3.1.4.17) (61 kDa Cam-PDE) (hCam-1) Calcium/calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cGMP and cAMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP. {ECO:0000269|PubMed:8557689}.
P20042 EIF2S2 T163 Sugiyama Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF2-beta) Component of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:31836389). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (By similarity). {ECO:0000250|UniProtKB:P05198, ECO:0000269|PubMed:31836389}.
Q9BQ70 TCF25 T86 Sugiyama Ribosome quality control complex subunit TCF25 (Nuclear localized protein 1) (Transcription factor 25) (TCF-25) Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:30244831). In the RQC complex, required to promote formation of 'Lys-48'-linked polyubiquitin chains during ubiquitination of incompletely synthesized proteins by LTN1 (PubMed:30244831). May negatively regulate the calcineurin-NFAT signaling cascade by suppressing the activity of transcription factor NFATC4 (By similarity). May play a role in cell death control (By similarity). {ECO:0000250|UniProtKB:A0A8I6ASZ5, ECO:0000250|UniProtKB:Q8R3L2, ECO:0000269|PubMed:30244831}.
Q8WWM7 ATXN2L T278 Sugiyama Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}.
P62873 GNB1 T34 Sugiyama Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1) Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems (PubMed:29925951, PubMed:33762731, PubMed:34239069, PubMed:35610220, PubMed:35714614, PubMed:35835867, PubMed:36087581, PubMed:36989299, PubMed:37327704, PubMed:37935376, PubMed:37935377, PubMed:37963465, PubMed:37991948, PubMed:38168118, PubMed:38552625). The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (PubMed:29925951, PubMed:33762731, PubMed:34239069, PubMed:35610220, PubMed:35714614, PubMed:35835867, PubMed:36087581, PubMed:36989299, PubMed:37327704, PubMed:37935376, PubMed:37935377, PubMed:37963465, PubMed:38168118, PubMed:38552625). {ECO:0000269|PubMed:29925951, ECO:0000269|PubMed:33762731, ECO:0000269|PubMed:34239069, ECO:0000269|PubMed:35610220, ECO:0000269|PubMed:35714614, ECO:0000269|PubMed:35835867, ECO:0000269|PubMed:36087581, ECO:0000269|PubMed:36989299, ECO:0000269|PubMed:37327704, ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377, ECO:0000269|PubMed:37963465, ECO:0000269|PubMed:37991948, ECO:0000269|PubMed:38168118, ECO:0000269|PubMed:38552625}.
Q96JX3 SERAC1 T455 Sugiyama Protein SERAC1 (Serine active site-containing protein 1) Facilitates the transport of serine from the cytosol to the mitochondria by interacting with and stabilizing Sideroflexin-1 (SFXN1), a mitochondrial serine transporter, playing a fundamental role in the one-carbon cycle responsible for the synthesis of nucleotides needed for mitochondrial DNA replication (PubMed:35235340). Plays an important role in the phosphatidylglycerol (PG) remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking (PubMed:22683713). Specifically involved in the exchange of the sn-1 acyl chain from PG 16:0/18:1(9Z) (also known as 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)) to PG 18:0/18:1(9Z) (also known as 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)), a step needed in the bis(monoacylglycerol)phosphate biosynthetic pathway (PubMed:22683713). May have acyltransferase activity although the mechanism for PG remodeling has not been determined (PubMed:22683713). {ECO:0000269|PubMed:22683713, ECO:0000269|PubMed:35235340}.
Q13554 CAMK2B T240 Sugiyama Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle (PubMed:16690701). In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). Phosphorylates reticulophagy regulator RETREG1 at 'Ser-151' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity (PubMed:31930741). {ECO:0000250|UniProtKB:P08413, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:29100089, ECO:0000269|PubMed:31930741}.
Q13555 CAMK2G T240 Sugiyama Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17) Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (PubMed:16690701). In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q923T9, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:30184290}.
Q13557 CAMK2D T240 Sugiyama Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17) Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program (PubMed:17179159). Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis (PubMed:16690701). May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6PHZ2, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:17179159}.
Q9UQM7 CAMK2A T239 Sugiyama Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17) Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation (PubMed:14722083). Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023). In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (PubMed:35568036). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity). {ECO:0000250|UniProtKB:P11275, ECO:0000250|UniProtKB:P11798, ECO:0000269|PubMed:11972023, ECO:0000269|PubMed:23805378, ECO:0000269|PubMed:28130356, ECO:0000269|PubMed:29100089}.
Q14164 IKBKE T156 Sugiyama Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i) Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' also seems to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1. {ECO:0000269|PubMed:17568778, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:19153231, ECO:0000269|PubMed:20188669, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:22532683, ECO:0000269|PubMed:23453969, ECO:0000269|PubMed:23478265}.
P98082 DAB2 T638 Sugiyama Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2) Adapter protein that functions as a clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor. {ECO:0000269|PubMed:11387212, ECO:0000269|PubMed:12805222, ECO:0000269|PubMed:16267015, ECO:0000269|PubMed:16984970, ECO:0000269|PubMed:19306879, ECO:0000269|PubMed:21995445, ECO:0000269|PubMed:22323290, ECO:0000269|PubMed:22491013}.
Q14155 ARHGEF7 T164 SIGNOR Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85) Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. {ECO:0000250, ECO:0000269|PubMed:18184567, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750}.
P22234 PAICS T40 Sugiyama Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) [Includes: Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC); Phosphoribosylaminoimidazole succinocarboxamide synthetase (EC 6.3.2.6) (SAICAR synthetase)] Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway. {ECO:0000269|PubMed:17224163, ECO:0000269|PubMed:2183217, ECO:0000269|PubMed:31600779}.
Q9NWZ3 IRAK4 T119 Sugiyama Interleukin-1 receptor-associated kinase 4 (IRAK-4) (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-64) Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways (PubMed:17878374). Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections. {ECO:0000269|PubMed:11960013, ECO:0000269|PubMed:12538665, ECO:0000269|PubMed:15084582, ECO:0000269|PubMed:17217339, ECO:0000269|PubMed:17337443, ECO:0000269|PubMed:17878374, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:20400509, ECO:0000269|PubMed:24316379}.
Q9UHD2 TBK1 T156 Sugiyama Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1) Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents (PubMed:10581243, PubMed:11839743, PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:15485837, PubMed:18583960, PubMed:21138416, PubMed:23453971, PubMed:23453972, PubMed:23746807, PubMed:25636800, PubMed:26611359, PubMed:32404352, PubMed:34363755, PubMed:32298923). Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X (PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:18583960, PubMed:25636800). This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB (PubMed:12702806, PubMed:15367631, PubMed:25636800, PubMed:32972995). In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli (PubMed:23453971, PubMed:23453972, PubMed:23746807). Plays a key role in IRF3 activation: acts by first phosphorylating innate adapter proteins MAVS, STING1 and TICAM1 on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 (PubMed:25636800, PubMed:30842653, PubMed:37926288). Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce expression of interferons (PubMed:25636800). Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes (PubMed:21931631). Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus (PubMed:10783893, PubMed:15489227). Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy (PubMed:21617041). Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation (PubMed:27103069). Phosphorylates ATG8 proteins MAP1LC3C and GABARAPL2, thereby preventing their delipidation and premature removal from nascent autophagosomes (PubMed:31709703). Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, which leads to a negative impact on insulin sensitivity (By similarity). Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C (PubMed:21270402). Phosphorylates Borna disease virus (BDV) P protein (PubMed:16155125). Plays an essential role in the TLR3- and IFN-dependent control of herpes virus HSV-1 and HSV-2 infections in the central nervous system (PubMed:22851595). Acts both as a positive and negative regulator of the mTORC1 complex, depending on the context: activates mTORC1 in response to growth factors by catalyzing phosphorylation of MTOR, while it limits the mTORC1 complex by promoting phosphorylation of RPTOR (PubMed:29150432, PubMed:31530866). Acts as a positive regulator of the mTORC2 complex by mediating phosphorylation of MTOR, leading to increased phosphorylation and activation of AKT1 (By similarity). Phosphorylates and activates AKT1 (PubMed:21464307). Involved in the regulation of TNF-induced RIPK1-mediated cell death, probably acting via CYLD phosphorylation that in turn controls RIPK1 ubiquitination status (PubMed:34363755). Also participates in the differentiation of T follicular regulatory cells together with the receptor ICOS (PubMed:27135603). {ECO:0000250|UniProtKB:Q9WUN2, ECO:0000269|PubMed:10581243, ECO:0000269|PubMed:10783893, ECO:0000269|PubMed:11839743, ECO:0000269|PubMed:12692549, ECO:0000269|PubMed:12702806, ECO:0000269|PubMed:14703513, ECO:0000269|PubMed:15367631, ECO:0000269|PubMed:15485837, ECO:0000269|PubMed:15489227, ECO:0000269|PubMed:16155125, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21270402, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:21617041, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:22851595, ECO:0000269|PubMed:23453971, ECO:0000269|PubMed:23453972, ECO:0000269|PubMed:23746807, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:26611359, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27135603, ECO:0000269|PubMed:29150432, ECO:0000269|PubMed:30842653, ECO:0000269|PubMed:31530866, ECO:0000269|PubMed:31709703, ECO:0000269|PubMed:32298923, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:34363755, ECO:0000269|PubMed:37926288}.
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reactome_id name p -log10_p
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 4.044753e-11 10.393
R-HSA-438064 Post NMDA receptor activation events 7.732577e-10 9.112
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 5.972877e-09 8.224
R-HSA-8953897 Cellular responses to stimuli 2.337829e-07 6.631
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 1.339198e-06 5.873
R-HSA-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 1.789566e-06 5.747
R-HSA-190872 Transport of connexons to the plasma membrane 2.305842e-06 5.637
R-HSA-389977 Post-chaperonin tubulin folding pathway 3.703468e-06 5.431
R-HSA-2262752 Cellular responses to stress 4.062867e-06 5.391
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation 5.723513e-06 5.242
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor 5.723513e-06 5.242
R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 5.723513e-06 5.242
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC 1.035108e-05 4.985
R-HSA-9620244 Long-term potentiation 1.243627e-05 4.905
R-HSA-3371556 Cellular response to heat stress 1.372926e-05 4.862
R-HSA-70171 Glycolysis 1.454005e-05 4.837
R-HSA-9656223 Signaling by RAF1 mutants 1.642891e-05 4.784
R-HSA-9841251 Mitochondrial unfolded protein response (UPRmt) 1.762513e-05 4.754
R-HSA-9619483 Activation of AMPK downstream of NMDARs 2.080600e-05 4.682
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 3.033029e-05 4.518
R-HSA-9649948 Signaling downstream of RAS mutants 3.033029e-05 4.518
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 3.033029e-05 4.518
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 2.702348e-05 4.568
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 3.108302e-05 4.507
R-HSA-6802949 Signaling by RAS mutants 3.033029e-05 4.518
R-HSA-390466 Chaperonin-mediated protein folding 2.870491e-05 4.542
R-HSA-190828 Gap junction trafficking 2.392141e-05 4.621
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 2.551248e-05 4.593
R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin 3.402822e-05 4.468
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 3.321494e-05 4.479
R-HSA-391251 Protein folding 4.563542e-05 4.341
R-HSA-157858 Gap junction trafficking and regulation 4.253908e-05 4.371
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 4.436666e-05 4.353
R-HSA-112315 Transmission across Chemical Synapses 4.419685e-05 4.355
R-HSA-9668328 Sealing of the nuclear envelope (NE) by ESCRT-III 4.436666e-05 4.353
R-HSA-428543 Inactivation of CDC42 and RAC1 4.640470e-05 4.333
R-HSA-5673000 RAF activation 5.833431e-05 4.234
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 5.571359e-05 4.254
R-HSA-111932 CaMK IV-mediated phosphorylation of CREB 6.312566e-05 4.200
R-HSA-190861 Gap junction assembly 5.833431e-05 4.234
R-HSA-70326 Glucose metabolism 5.787991e-05 4.237
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 7.909819e-05 4.102
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 8.407652e-05 4.075
R-HSA-9833482 PKR-mediated signaling 9.835522e-05 4.007
R-HSA-913531 Interferon Signaling 1.011094e-04 3.995
R-HSA-9646399 Aggrephagy 1.223205e-04 3.913
R-HSA-422475 Axon guidance 1.247061e-04 3.904
R-HSA-6802957 Oncogenic MAPK signaling 1.430337e-04 3.845
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 1.506007e-04 3.822
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 1.638187e-04 3.786
R-HSA-9663891 Selective autophagy 1.897914e-04 3.722
R-HSA-1489509 DAG and IP3 signaling 2.324410e-04 3.634
R-HSA-3270619 IRF3-mediated induction of type I IFN 2.673475e-04 3.573
R-HSA-437239 Recycling pathway of L1 2.827663e-04 3.549
R-HSA-9675108 Nervous system development 2.985348e-04 3.525
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 3.109417e-04 3.507
R-HSA-399719 Trafficking of AMPA receptors 3.499322e-04 3.456
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 3.626638e-04 3.440
R-HSA-9022692 Regulation of MECP2 expression and activity 4.437733e-04 3.353
R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity 4.437733e-04 3.353
R-HSA-111885 Opioid Signalling 5.811047e-04 3.236
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 5.878709e-04 3.231
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 6.185776e-04 3.209
R-HSA-6804757 Regulation of TP53 Degradation 6.869587e-04 3.163
R-HSA-1834941 STING mediated induction of host immune responses 6.397430e-04 3.194
R-HSA-68877 Mitotic Prometaphase 6.795415e-04 3.168
R-HSA-111933 Calmodulin induced events 6.869587e-04 3.163
R-HSA-111997 CaM pathway 6.869587e-04 3.163
R-HSA-9609690 HCMV Early Events 7.610797e-04 3.119
R-HSA-2467813 Separation of Sister Chromatids 7.706604e-04 3.113
R-HSA-68886 M Phase 8.399966e-04 3.076
R-HSA-112043 PLC beta mediated events 9.176557e-04 3.037
R-HSA-983189 Kinesins 8.517631e-04 3.070
R-HSA-6806003 Regulation of TP53 Expression and Degradation 9.262151e-04 3.033
R-HSA-112316 Neuronal System 9.550108e-04 3.020
R-HSA-162582 Signal Transduction 1.076432e-03 2.968
R-HSA-1632852 Macroautophagy 1.093308e-03 2.961
R-HSA-373760 L1CAM interactions 1.266517e-03 2.897
R-HSA-8986944 Transcriptional Regulation by MECP2 1.226415e-03 2.911
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 1.282096e-03 2.892
R-HSA-111996 Ca-dependent events 1.335307e-03 2.874
R-HSA-112040 G-protein mediated events 1.399286e-03 2.854
R-HSA-68882 Mitotic Anaphase 1.589975e-03 2.799
R-HSA-2555396 Mitotic Metaphase and Anaphase 1.642982e-03 2.784
R-HSA-1640170 Cell Cycle 1.537390e-03 2.813
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 1.495381e-03 2.825
R-HSA-6807878 COPI-mediated anterograde transport 1.794756e-03 2.746
R-HSA-5620920 Cargo trafficking to the periciliary membrane 1.813998e-03 2.741
R-HSA-69275 G2/M Transition 1.850651e-03 2.733
R-HSA-453274 Mitotic G2-G2/M phases 1.984497e-03 2.702
R-HSA-5620924 Intraflagellar transport 2.179953e-03 2.662
R-HSA-9006925 Intracellular signaling by second messengers 2.219424e-03 2.654
R-HSA-9612973 Autophagy 2.097310e-03 2.678
R-HSA-74160 Gene expression (Transcription) 2.147175e-03 2.668
R-HSA-3700989 Transcriptional Regulation by TP53 2.233317e-03 2.651
R-HSA-451326 Activation of kainate receptors upon glutamate binding 2.277624e-03 2.643
R-HSA-5576892 Phase 0 - rapid depolarisation 2.277624e-03 2.643
R-HSA-3371571 HSF1-dependent transactivation 2.723854e-03 2.565
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 2.793132e-03 2.554
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 3.078578e-03 2.512
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 3.078578e-03 2.512
R-HSA-1855170 IPs transport between nucleus and cytosol 3.707951e-03 2.431
R-HSA-159227 Transport of the SLBP independent Mature mRNA 3.707951e-03 2.431
R-HSA-5578775 Ion homeostasis 3.839094e-03 2.416
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 4.053088e-03 2.392
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 4.053088e-03 2.392
R-HSA-9609646 HCMV Infection 4.387122e-03 2.358
R-HSA-180746 Nuclear import of Rev protein 4.419314e-03 2.355
R-HSA-191859 snRNP Assembly 4.646997e-03 2.333
R-HSA-194441 Metabolism of non-coding RNA 4.646997e-03 2.333
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 4.807208e-03 2.318
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 5.903107e-03 2.229
R-HSA-380259 Loss of Nlp from mitotic centrosomes 5.903107e-03 2.229
R-HSA-180910 Vpr-mediated nuclear import of PICs 5.650251e-03 2.248
R-HSA-447038 NrCAM interactions 5.732012e-03 2.242
R-HSA-199977 ER to Golgi Anterograde Transport 5.339199e-03 2.273
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 5.875539e-03 2.231
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 6.106497e-03 2.214
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 6.586602e-03 2.181
R-HSA-168276 NS1 Mediated Effects on Host Pathways 6.586602e-03 2.181
R-HSA-5617833 Cilium Assembly 6.807895e-03 2.167
R-HSA-8854518 AURKA Activation by TPX2 6.989788e-03 2.156
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 7.091082e-03 2.149
R-HSA-177243 Interactions of Rev with host cellular proteins 7.091082e-03 2.149
R-HSA-176033 Interactions of Vpr with host cellular proteins 7.091082e-03 2.149
R-HSA-5674499 Negative feedback regulation of MAPK pathway 7.409142e-03 2.130
R-HSA-427652 Sodium-coupled phosphate cotransporters 7.409142e-03 2.130
R-HSA-162587 HIV Life Cycle 7.482390e-03 2.126
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 7.620438e-03 2.118
R-HSA-3214841 PKMTs methylate histone lysines 7.620438e-03 2.118
R-HSA-1852241 Organelle biogenesis and maintenance 8.943028e-03 2.049
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 7.785609e-03 2.109
R-HSA-3247509 Chromatin modifying enzymes 8.109628e-03 2.091
R-HSA-5610787 Hedgehog 'off' state 9.214820e-03 2.036
R-HSA-1280215 Cytokine Signaling in Immune system 9.235984e-03 2.035
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 9.995632e-03 2.000
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 1.005424e-02 1.998
R-HSA-4086398 Ca2+ pathway 1.005424e-02 1.998
R-HSA-8856688 Golgi-to-ER retrograde transport 1.012440e-02 1.995
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 1.065695e-02 1.972
R-HSA-380287 Centrosome maturation 1.107565e-02 1.956
R-HSA-72731 Recycling of eIF2:GDP 1.133860e-02 1.945
R-HSA-9726840 SHOC2 M1731 mutant abolishes MRAS complex function 1.133860e-02 1.945
R-HSA-8949275 RUNX3 Regulates Immune Response and Cell Migration 1.133860e-02 1.945
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 1.134531e-02 1.945
R-HSA-446107 Type I hemidesmosome assembly 1.357812e-02 1.867
R-HSA-9828211 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 1.357812e-02 1.867
R-HSA-9660537 Signaling by MRAS-complex mutants 1.357812e-02 1.867
R-HSA-9726842 Gain-of-function MRAS complexes activate RAF signaling 1.357812e-02 1.867
R-HSA-429947 Deadenylation of mRNA 1.259874e-02 1.900
R-HSA-392451 G beta:gamma signalling through PI3Kgamma 1.151221e-02 1.939
R-HSA-3858494 Beta-catenin independent WNT signaling 1.196505e-02 1.922
R-HSA-195721 Signaling by WNT 1.379982e-02 1.860
R-HSA-442729 CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde 1.357812e-02 1.867
R-HSA-9825895 Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... 1.357812e-02 1.867
R-HSA-69278 Cell Cycle, Mitotic 1.355042e-02 1.868
R-HSA-70263 Gluconeogenesis 1.280638e-02 1.893
R-HSA-4839726 Chromatin organization 1.175157e-02 1.930
R-HSA-162599 Late Phase of HIV Life Cycle 1.493248e-02 1.826
R-HSA-170984 ARMS-mediated activation 1.599254e-02 1.796
R-HSA-9619229 Activation of RAC1 downstream of NMDARs 1.599254e-02 1.796
R-HSA-9840373 Cellular response to mitochondrial stress 1.599254e-02 1.796
R-HSA-9855142 Cellular responses to mechanical stimuli 1.625119e-02 1.789
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 1.654934e-02 1.781
R-HSA-212436 Generic Transcription Pathway 1.709645e-02 1.767
R-HSA-162906 HIV Infection 1.839968e-02 1.735
R-HSA-451308 Activation of Ca-permeable Kainate Receptor 1.857582e-02 1.731
R-HSA-2980766 Nuclear Envelope Breakdown 2.084142e-02 1.681
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 2.118234e-02 1.674
R-HSA-451306 Ionotropic activity of kainate receptors 2.132210e-02 1.671
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 2.187430e-02 1.660
R-HSA-212165 Epigenetic regulation of gene expression 2.260660e-02 1.646
R-HSA-73857 RNA Polymerase II Transcription 2.276069e-02 1.643
R-HSA-429914 Deadenylation-dependent mRNA decay 2.296539e-02 1.639
R-HSA-2132295 MHC class II antigen presentation 2.332081e-02 1.632
R-HSA-9824878 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 2.422562e-02 1.616
R-HSA-9623433 NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 2.422562e-02 1.616
R-HSA-9013973 TICAM1-dependent activation of IRF3/IRF7 2.422562e-02 1.616
R-HSA-381183 ATF6 (ATF6-alpha) activates chaperone genes 2.422562e-02 1.616
R-HSA-397795 G-protein beta:gamma signalling 2.496497e-02 1.603
R-HSA-9673013 Diseases of Telomere Maintenance 3.129707e-02 1.504
R-HSA-9670621 Defective Inhibition of DNA Recombination at Telomere 3.129707e-02 1.504
R-HSA-9006821 Alternative Lengthening of Telomeres (ALT) 3.129707e-02 1.504
R-HSA-9670613 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations 3.129707e-02 1.504
R-HSA-9699150 Defective DNA double strand break response due to BARD1 loss of function 3.129707e-02 1.504
R-HSA-9663199 Defective DNA double strand break response due to BRCA1 loss of function 3.129707e-02 1.504
R-HSA-9670615 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations 3.129707e-02 1.504
R-HSA-5673001 RAF/MAP kinase cascade 2.743551e-02 1.562
R-HSA-168325 Viral Messenger RNA Synthesis 2.521647e-02 1.598
R-HSA-5684996 MAPK1/MAPK3 signaling 3.124969e-02 1.505
R-HSA-6784531 tRNA processing in the nucleus 2.639013e-02 1.579
R-HSA-948021 Transport to the Golgi and subsequent modification 2.632285e-02 1.580
R-HSA-381033 ATF6 (ATF6-alpha) activates chaperones 3.048213e-02 1.516
R-HSA-936837 Ion transport by P-type ATPases 2.883445e-02 1.540
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... 3.010538e-02 1.521
R-HSA-8853659 RET signaling 3.196900e-02 1.495
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 3.386406e-02 1.470
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 3.386406e-02 1.470
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 3.695167e-02 1.432
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 3.696657e-02 1.432
R-HSA-8964315 G beta:gamma signalling through BTK 3.730214e-02 1.428
R-HSA-69541 Stabilization of p53 3.782525e-02 1.422
R-HSA-8953750 Transcriptional Regulation by E2F6 3.782525e-02 1.422
R-HSA-9860931 Response of endothelial cells to shear stress 3.790145e-02 1.421
R-HSA-5358351 Signaling by Hedgehog 3.887969e-02 1.410
R-HSA-5578749 Transcriptional regulation by small RNAs 3.992082e-02 1.399
R-HSA-199991 Membrane Trafficking 4.018552e-02 1.396
R-HSA-169893 Prolonged ERK activation events 4.091054e-02 1.388
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 4.145495e-02 1.382
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 4.201230e-02 1.377
R-HSA-5218920 VEGFR2 mediated vascular permeability 4.201230e-02 1.377
R-HSA-5619045 Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) 4.657777e-02 1.332
R-HSA-5687583 Defective SLC34A2 causes PALM 4.657777e-02 1.332
R-HSA-418217 G beta:gamma signalling through PLC beta 5.247025e-02 1.280
R-HSA-9709603 Impaired BRCA2 binding to PALB2 5.655264e-02 1.248
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 4.407037e-02 1.356
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 5.674483e-02 1.246
R-HSA-8964616 G beta:gamma signalling through CDC42 4.464455e-02 1.350
R-HSA-5674135 MAP2K and MAPK activation 4.418957e-02 1.355
R-HSA-72737 Cap-dependent Translation Initiation 5.811682e-02 1.236
R-HSA-72613 Eukaryotic Translation Initiation 5.811682e-02 1.236
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 4.464455e-02 1.350
R-HSA-5693532 DNA Double-Strand Break Repair 5.723621e-02 1.242
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 4.407037e-02 1.356
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 5.414158e-02 1.266
R-HSA-3928664 Ephrin signaling 5.247025e-02 1.280
R-HSA-936964 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 4.464455e-02 1.350
R-HSA-392851 Prostacyclin signalling through prostacyclin receptor 5.655264e-02 1.248
R-HSA-9636667 Manipulation of host energy metabolism 4.657777e-02 1.332
R-HSA-500657 Presynaptic function of Kainate receptors 5.247025e-02 1.280
R-HSA-918233 TRAF3-dependent IRF activation pathway 4.464455e-02 1.350
R-HSA-165159 MTOR signalling 4.642208e-02 1.333
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 4.642208e-02 1.333
R-HSA-9675151 Disorders of Developmental Biology 4.464455e-02 1.350
R-HSA-416482 G alpha (12/13) signalling events 4.962078e-02 1.304
R-HSA-1433557 Signaling by SCF-KIT 4.870937e-02 1.312
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 4.414497e-02 1.355
R-HSA-6804760 Regulation of TP53 Activity through Methylation 5.247025e-02 1.280
R-HSA-1483249 Inositol phosphate metabolism 4.941456e-02 1.306
R-HSA-8849932 Synaptic adhesion-like molecules 5.247025e-02 1.280
R-HSA-1280218 Adaptive Immune System 5.568787e-02 1.254
R-HSA-1169408 ISG15 antiviral mechanism 4.462232e-02 1.350
R-HSA-9020591 Interleukin-12 signaling 4.625553e-02 1.335
R-HSA-9007101 Rab regulation of trafficking 5.964729e-02 1.224
R-HSA-597592 Post-translational protein modification 5.964952e-02 1.224
R-HSA-168273 Influenza Viral RNA Transcription and Replication 5.984188e-02 1.223
R-HSA-983169 Class I MHC mediated antigen processing & presentation 6.019276e-02 1.220
R-HSA-9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function 6.074205e-02 1.217
R-HSA-9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 6.074205e-02 1.217
R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 6.074205e-02 1.217
R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 6.074205e-02 1.217
R-HSA-6807004 Negative regulation of MET activity 6.074205e-02 1.217
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 6.256655e-02 1.204
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 6.355400e-02 1.197
R-HSA-69563 p53-Dependent G1 DNA Damage Response 6.355400e-02 1.197
R-HSA-9766229 Degradation of CDH1 6.355400e-02 1.197
R-HSA-392499 Metabolism of proteins 6.380616e-02 1.195
R-HSA-68875 Mitotic Prophase 6.437567e-02 1.191
R-HSA-202040 G-protein activation 6.503412e-02 1.187
R-HSA-392170 ADP signalling through P2Y purinoceptor 12 6.503412e-02 1.187
R-HSA-5357786 TNFR1-induced proapoptotic signaling 6.503412e-02 1.187
R-HSA-877300 Interferon gamma signaling 6.526253e-02 1.185
R-HSA-376176 Signaling by ROBO receptors 6.621954e-02 1.179
R-HSA-5633007 Regulation of TP53 Activity 6.666131e-02 1.176
R-HSA-447115 Interleukin-12 family signaling 6.840248e-02 1.165
R-HSA-168256 Immune System 6.919689e-02 1.160
R-HSA-5603041 IRAK4 deficiency (TLR2/4) 6.942460e-02 1.158
R-HSA-8876384 Listeria monocytogenes entry into host cells 6.942460e-02 1.158
R-HSA-5683057 MAPK family signaling cascades 7.069726e-02 1.151
R-HSA-162909 Host Interactions of HIV factors 7.099855e-02 1.149
R-HSA-112382 Formation of RNA Pol II elongation complex 7.167040e-02 1.145
R-HSA-350054 Notch-HLH transcription pathway 7.390935e-02 1.131
R-HSA-166208 mTORC1-mediated signalling 7.390935e-02 1.131
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 7.390935e-02 1.131
R-HSA-75955 RNA Polymerase II Transcription Elongation 7.447440e-02 1.128
R-HSA-9944997 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome 7.642257e-02 1.117
R-HSA-9944971 Loss of Function of KMT2D in Kabuki Syndrome 7.642257e-02 1.117
R-HSA-5603037 IRAK4 deficiency (TLR5) 7.642257e-02 1.117
R-HSA-165181 Inhibition of TSC complex formation by PKB 9.099413e-02 1.041
R-HSA-1306955 GRB7 events in ERBB2 signaling 9.099413e-02 1.041
R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 8.788931e-02 1.056
R-HSA-1296041 Activation of G protein gated Potassium channels 8.788931e-02 1.056
R-HSA-1296059 G protein gated Potassium channels 8.788931e-02 1.056
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 8.788931e-02 1.056
R-HSA-9709570 Impaired BRCA2 binding to RAD51 1.076155e-01 0.968
R-HSA-72649 Translation initiation complex formation 7.732653e-02 1.112
R-HSA-72702 Ribosomal scanning and start codon recognition 8.317231e-02 1.080
R-HSA-8957275 Post-translational protein phosphorylation 9.750281e-02 1.011
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 9.228372e-02 1.035
R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 9.033770e-02 1.044
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 1.069348e-01 0.971
R-HSA-428930 Thromboxane signalling through TP receptor 8.314559e-02 1.080
R-HSA-1606341 IRF3 mediated activation of type 1 IFN 1.053367e-01 0.977
R-HSA-165158 Activation of AKT2 1.053367e-01 0.977
R-HSA-8849472 PTK6 Down-Regulation 1.053367e-01 0.977
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion 9.271175e-02 1.033
R-HSA-3214815 HDACs deacetylate histones 8.022608e-02 1.096
R-HSA-9764561 Regulation of CDH1 Function 8.616449e-02 1.065
R-HSA-389357 CD28 dependent PI3K/Akt signaling 9.760927e-02 1.011
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 1.127173e-01 0.948
R-HSA-9909396 Circadian clock 8.912443e-02 1.050
R-HSA-3249367 STAT6-mediated induction of chemokines 7.642257e-02 1.117
R-HSA-427589 Type II Na+/Pi cotransporters 7.642257e-02 1.117
R-HSA-211163 AKT-mediated inactivation of FOXO1A 9.099413e-02 1.041
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 8.920188e-02 1.050
R-HSA-418592 ADP signalling through P2Y purinoceptor 1 8.314559e-02 1.080
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs) 1.127173e-01 0.948
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 1.125977e-01 0.948
R-HSA-1660514 Synthesis of PIPs at the Golgi membrane 9.271175e-02 1.033
R-HSA-8943724 Regulation of PTEN gene transcription 9.540923e-02 1.020
R-HSA-69615 G1/S DNA Damage Checkpoints 1.050401e-01 0.979
R-HSA-422356 Regulation of insulin secretion 9.750281e-02 1.011
R-HSA-418594 G alpha (i) signalling events 8.240923e-02 1.084
R-HSA-69620 Cell Cycle Checkpoints 7.834025e-02 1.106
R-HSA-9648895 Response of EIF2AK1 (HRI) to heme deficiency 7.848432e-02 1.105
R-HSA-8953854 Metabolism of RNA 9.097170e-02 1.041
R-HSA-201681 TCF dependent signaling in response to WNT 1.054052e-01 0.977
R-HSA-5576891 Cardiac conduction 8.721252e-02 1.059
R-HSA-8878159 Transcriptional regulation by RUNX3 9.508546e-02 1.022
R-HSA-9705683 SARS-CoV-2-host interactions 1.031621e-01 0.986
R-HSA-420092 Glucagon-type ligand receptors 1.076155e-01 0.968
R-HSA-6807070 PTEN Regulation 1.051918e-01 0.978
R-HSA-168255 Influenza Infection 9.826921e-02 1.008
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 8.317231e-02 1.080
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 7.848432e-02 1.105
R-HSA-9824446 Viral Infection Pathways 1.042372e-01 0.982
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 8.342086e-02 1.079
R-HSA-9022699 MECP2 regulates neuronal receptors and channels 9.271175e-02 1.033
R-HSA-381119 Unfolded Protein Response (UPR) 1.051918e-01 0.978
R-HSA-5653656 Vesicle-mediated transport 1.137843e-01 0.944
R-HSA-983712 Ion channel transport 1.165996e-01 0.933
R-HSA-182971 EGFR downregulation 1.178806e-01 0.929
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling 1.178806e-01 0.929
R-HSA-5693606 DNA Double Strand Break Response 1.184449e-01 0.926
R-HSA-9833576 CDH11 homotypic and heterotypic interactions 1.194538e-01 0.923
R-HSA-111957 Cam-PDE 1 activation 1.194538e-01 0.923
R-HSA-9022537 Loss of MECP2 binding ability to the NCoR/SMRT complex 1.194538e-01 0.923
R-HSA-5340588 Signaling by RNF43 mutants 1.194538e-01 0.923
R-HSA-109703 PKB-mediated events 1.194538e-01 0.923
R-HSA-165160 PDE3B signalling 1.194538e-01 0.923
R-HSA-187706 Signalling to p38 via RIT and RIN 1.194538e-01 0.923
R-HSA-9764302 Regulation of CDH19 Expression and Function 1.194538e-01 0.923
R-HSA-1266738 Developmental Biology 1.194689e-01 0.923
R-HSA-418346 Platelet homeostasis 1.205113e-01 0.919
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 1.218914e-01 0.914
R-HSA-1643685 Disease 1.227707e-01 0.911
R-HSA-1296065 Inwardly rectifying K+ channels 1.231022e-01 0.910
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 1.231022e-01 0.910
R-HSA-111465 Apoptotic cleavage of cellular proteins 1.231022e-01 0.910
R-HSA-211000 Gene Silencing by RNA 1.232014e-01 0.909
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 1.283789e-01 0.892
R-HSA-354192 Integrin signaling 1.283789e-01 0.892
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 1.283789e-01 0.892
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 1.283789e-01 0.892
R-HSA-9842640 Signaling by LTK in cancer 1.333490e-01 0.875
R-HSA-9645135 STAT5 Activation 1.333490e-01 0.875
R-HSA-9732724 IFNG signaling activates MAPKs 1.470258e-01 0.833
R-HSA-196025 Formation of annular gap junctions 1.604876e-01 0.795
R-HSA-190873 Gap junction degradation 1.737377e-01 0.760
R-HSA-198693 AKT phosphorylates targets in the nucleus 1.737377e-01 0.760
R-HSA-164843 2-LTR circle formation 1.867795e-01 0.729
R-HSA-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 1.867795e-01 0.729
R-HSA-5358493 Synthesis of diphthamide-EEF2 2.122512e-01 0.673
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 2.122512e-01 0.673
R-HSA-198323 AKT phosphorylates targets in the cytosol 2.246874e-01 0.648
R-HSA-2197563 NOTCH2 intracellular domain regulates transcription 2.246874e-01 0.648
R-HSA-9820865 Z-decay: degradation of maternal mRNAs by zygotically expressed factors 2.246874e-01 0.648
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 2.369281e-01 0.625
R-HSA-5696400 Dual Incision in GG-NER 1.390858e-01 0.857
R-HSA-9927426 Developmental Lineage of Mammary Gland Alveolar Cells 1.390858e-01 0.857
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 1.722323e-01 0.764
R-HSA-9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells 1.892547e-01 0.723
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 2.122761e-01 0.673
R-HSA-141424 Amplification of signal from the kinetochores 1.893714e-01 0.723
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 1.893714e-01 0.723
R-HSA-156902 Peptide chain elongation 2.014326e-01 0.696
R-HSA-9948299 Ribosome-associated quality control 2.342328e-01 0.630
R-HSA-5693607 Processing of DNA double-strand break ends 1.697167e-01 0.770
R-HSA-9664873 Pexophagy 1.867795e-01 0.729
R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization 2.369281e-01 0.625
R-HSA-9762292 Regulation of CDH11 function 1.867795e-01 0.729
R-HSA-8876493 InlA-mediated entry of Listeria monocytogenes into host cells 1.996163e-01 0.700
R-HSA-5696395 Formation of Incision Complex in GG-NER 1.722323e-01 0.764
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 1.390858e-01 0.857
R-HSA-9931530 Phosphorylation and nuclear translocation of the CRY:PER:kinase complex 2.246874e-01 0.648
R-HSA-8941856 RUNX3 regulates NOTCH signaling 2.246874e-01 0.648
R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes) 1.666165e-01 0.778
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 1.666165e-01 0.778
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 2.297134e-01 0.639
R-HSA-109704 PI3K Cascade 2.355483e-01 0.628
R-HSA-1221632 Meiotic synapsis 2.530956e-01 0.597
R-HSA-674695 RNA Polymerase II Pre-transcription Events 1.433079e-01 0.844
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 1.390858e-01 0.857
R-HSA-392518 Signal amplification 1.390858e-01 0.857
R-HSA-5693537 Resolution of D-Loop Structures 1.337077e-01 0.874
R-HSA-427413 NoRC negatively regulates rRNA expression 1.324466e-01 0.878
R-HSA-69618 Mitotic Spindle Checkpoint 2.597113e-01 0.586
R-HSA-76009 Platelet Aggregation (Plug Formation) 2.064924e-01 0.685
R-HSA-156842 Eukaryotic Translation Elongation 2.219143e-01 0.654
R-HSA-177135 Conjugation of benzoate with glycine 1.996163e-01 0.700
R-HSA-177128 Conjugation of salicylate with glycine 2.246874e-01 0.648
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 1.390858e-01 0.857
R-HSA-1500620 Meiosis 1.853937e-01 0.732
R-HSA-170968 Frs2-mediated activation 2.369281e-01 0.625
R-HSA-187687 Signalling to ERKs 1.445102e-01 0.840
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 1.390858e-01 0.857
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 1.610338e-01 0.793
R-HSA-9634597 GPER1 signaling 2.238886e-01 0.650
R-HSA-912446 Meiotic recombination 2.413914e-01 0.617
R-HSA-933541 TRAF6 mediated IRF7 activation 1.554869e-01 0.808
R-HSA-1433559 Regulation of KIT signaling 2.489762e-01 0.604
R-HSA-991365 Activation of GABAB receptors 1.892547e-01 0.723
R-HSA-5675221 Negative regulation of MAPK pathway 1.835537e-01 0.736
R-HSA-5693548 Sensing of DNA Double Strand Breaks 2.122512e-01 0.673
R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation 2.489762e-01 0.604
R-HSA-977444 GABA B receptor activation 1.892547e-01 0.723
R-HSA-4086400 PCP/CE pathway 1.582274e-01 0.801
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 1.658601e-01 0.780
R-HSA-6794362 Protein-protein interactions at synapses 1.853937e-01 0.732
R-HSA-76002 Platelet activation, signaling and aggregation 1.901936e-01 0.721
R-HSA-73894 DNA Repair 2.600962e-01 0.585
R-HSA-9711097 Cellular response to starvation 1.509790e-01 0.821
R-HSA-1257604 PIP3 activates AKT signaling 1.321138e-01 0.879
R-HSA-1679131 Trafficking and processing of endosomal TLR 2.246874e-01 0.648
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 1.445102e-01 0.840
R-HSA-5602358 Diseases associated with the TLR signaling cascade 1.722323e-01 0.764
R-HSA-5260271 Diseases of Immune System 1.722323e-01 0.764
R-HSA-168898 Toll-like Receptor Cascades 2.436528e-01 0.613
R-HSA-389356 Co-stimulation by CD28 2.238886e-01 0.650
R-HSA-877312 Regulation of IFNG signaling 2.246874e-01 0.648
R-HSA-418457 cGMP effects 2.489762e-01 0.604
R-HSA-9660821 ADORA2B mediated anti-inflammatory cytokines production 2.064924e-01 0.685
R-HSA-69473 G2/M DNA damage checkpoint 1.433079e-01 0.844
R-HSA-9816359 Maternal to zygotic transition (MZT) 1.756472e-01 0.755
R-HSA-430116 GP1b-IX-V activation signalling 1.737377e-01 0.760
R-HSA-162592 Integration of provirus 2.122512e-01 0.673
R-HSA-9607240 FLT3 Signaling 1.778788e-01 0.750
R-HSA-9675135 Diseases of DNA repair 2.122761e-01 0.673
R-HSA-5336415 Uptake and function of diphtheria toxin 1.470258e-01 0.833
R-HSA-9614399 Regulation of localization of FOXO transcription factors 1.996163e-01 0.700
R-HSA-9005891 Loss of function of MECP2 in Rett syndrome 2.246874e-01 0.648
R-HSA-9005895 Pervasive developmental disorders 2.246874e-01 0.648
R-HSA-9697154 Disorders of Nervous System Development 2.246874e-01 0.648
R-HSA-9755779 SARS-CoV-2 targets host intracellular signalling and regulatory pathways 2.608348e-01 0.584
R-HSA-111447 Activation of BAD and translocation to mitochondria 2.608348e-01 0.584
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins 2.064924e-01 0.685
R-HSA-3214847 HATs acetylate histones 2.554650e-01 0.593
R-HSA-1295596 Spry regulation of FGF signaling 2.608348e-01 0.584
R-HSA-381042 PERK regulates gene expression 1.445102e-01 0.840
R-HSA-163685 Integration of energy metabolism 2.274897e-01 0.643
R-HSA-446728 Cell junction organization 1.988950e-01 0.701
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 2.584331e-01 0.588
R-HSA-163359 Glucagon signaling in metabolic regulation 1.337077e-01 0.874
R-HSA-69481 G2/M Checkpoints 1.914003e-01 0.718
R-HSA-8948751 Regulation of PTEN stability and activity 2.530956e-01 0.597
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 1.933710e-01 0.714
R-HSA-5628897 TP53 Regulates Metabolic Genes 1.485193e-01 0.828
R-HSA-74752 Signaling by Insulin receptor 2.219143e-01 0.654
R-HSA-8941332 RUNX2 regulates genes involved in cell migration 1.996163e-01 0.700
R-HSA-5687613 Diseases associated with surfactant metabolism 2.246874e-01 0.648
R-HSA-8854214 TBC/RABGAPs 1.949796e-01 0.710
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 1.893714e-01 0.723
R-HSA-8878171 Transcriptional regulation by RUNX1 1.998044e-01 0.699
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 1.445102e-01 0.840
R-HSA-9764265 Regulation of CDH1 Expression and Function 1.926324e-01 0.715
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 1.926324e-01 0.715
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 1.658601e-01 0.780
R-HSA-1358803 Downregulation of ERBB2:ERBB3 signaling 2.246874e-01 0.648
R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell 2.608348e-01 0.584
R-HSA-5689880 Ub-specific processing proteases 1.926324e-01 0.715
R-HSA-8983432 Interleukin-15 signaling 2.246874e-01 0.648
R-HSA-8876725 Protein methylation 2.608348e-01 0.584
R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 1.737377e-01 0.760
R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors 2.369281e-01 0.625
R-HSA-170834 Signaling by TGF-beta Receptor Complex 2.470033e-01 0.607
R-HSA-9958790 SLC-mediated transport of inorganic anions 1.610338e-01 0.793
R-HSA-373080 Class B/2 (Secretin family receptors) 2.095722e-01 0.679
R-HSA-5663205 Infectious disease 1.425987e-01 0.846
R-HSA-4420097 VEGFA-VEGFR2 Pathway 1.514490e-01 0.820
R-HSA-382556 ABC-family proteins mediated transport 2.597113e-01 0.586
R-HSA-9764790 Positive Regulation of CDH1 Gene Transcription 1.867795e-01 0.729
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 1.456119e-01 0.837
R-HSA-194138 Signaling by VEGF 1.850452e-01 0.733
R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 1.835537e-01 0.736
R-HSA-5357905 Regulation of TNFR1 signaling 2.122761e-01 0.673
R-HSA-9614085 FOXO-mediated transcription 2.554650e-01 0.593
R-HSA-75153 Apoptotic execution phase 2.122761e-01 0.673
R-HSA-5619115 Disorders of transmembrane transporters 2.531354e-01 0.597
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 2.472410e-01 0.607
R-HSA-5619102 SLC transporter disorders 1.739214e-01 0.760
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 2.288262e-01 0.640
R-HSA-9009391 Extra-nuclear estrogen signaling 2.639669e-01 0.578
R-HSA-418597 G alpha (z) signalling events 2.648129e-01 0.577
R-HSA-1483255 PI Metabolism 2.682311e-01 0.571
R-HSA-177929 Signaling by EGFR 2.706727e-01 0.568
R-HSA-193648 NRAGE signals death through JNK 2.706727e-01 0.568
R-HSA-75893 TNF signaling 2.706727e-01 0.568
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 2.720982e-01 0.565
R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins 2.725069e-01 0.565
R-HSA-5083625 Defective GALNT3 causes HFTC 2.725069e-01 0.565
R-HSA-5083636 Defective GALNT12 causes CRCS1 2.725069e-01 0.565
R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 2.725069e-01 0.565
R-HSA-2485179 Activation of the phototransduction cascade 2.725069e-01 0.565
R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic... 2.725069e-01 0.565
R-HSA-388844 Receptor-type tyrosine-protein phosphatases 2.725069e-01 0.565
R-HSA-71262 Carnitine synthesis 2.725069e-01 0.565
R-HSA-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases 2.725069e-01 0.565
R-HSA-5688426 Deubiquitination 2.744314e-01 0.562
R-HSA-112399 IRS-mediated signalling 2.765312e-01 0.558
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 2.765312e-01 0.558
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 2.767830e-01 0.558
R-HSA-6782135 Dual incision in TC-NER 2.823871e-01 0.549
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 2.823871e-01 0.549
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 2.823871e-01 0.549
R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 2.839954e-01 0.547
R-HSA-3134975 Regulation of innate immune responses to cytosolic DNA 2.839954e-01 0.547
R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease 2.839954e-01 0.547
R-HSA-9702518 STAT5 activation downstream of FLT3 ITD mutants 2.839954e-01 0.547
R-HSA-399997 Acetylcholine regulates insulin secretion 2.839954e-01 0.547
R-HSA-388396 GPCR downstream signalling 2.850873e-01 0.545
R-HSA-1500931 Cell-Cell communication 2.881935e-01 0.540
R-HSA-186712 Regulation of beta-cell development 2.882389e-01 0.540
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures 2.882389e-01 0.540
R-HSA-72766 Translation 2.895737e-01 0.538
R-HSA-73887 Death Receptor Signaling 2.931865e-01 0.533
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 2.940855e-01 0.532
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 2.940855e-01 0.532
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 2.940855e-01 0.532
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 2.940855e-01 0.532
R-HSA-2644603 Signaling by NOTCH1 in Cancer 2.940855e-01 0.532
R-HSA-977443 GABA receptor activation 2.940855e-01 0.532
R-HSA-1227986 Signaling by ERBB2 2.940855e-01 0.532
R-HSA-372708 p130Cas linkage to MAPK signaling for integrins 2.953032e-01 0.530
R-HSA-5083632 Defective C1GALT1C1 causes TNPS 2.953032e-01 0.530
R-HSA-4641263 Regulation of FZD by ubiquitination 2.953032e-01 0.530
R-HSA-1660517 Synthesis of PIPs at the late endosome membrane 2.953032e-01 0.530
R-HSA-139853 Elevation of cytosolic Ca2+ levels 2.953032e-01 0.530
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 2.982693e-01 0.525
R-HSA-1236975 Antigen processing-Cross presentation 2.982693e-01 0.525
R-HSA-2428928 IRS-related events triggered by IGF1R 2.999254e-01 0.523
R-HSA-445717 Aquaporin-mediated transport 2.999254e-01 0.523
R-HSA-9793380 Formation of paraxial mesoderm 2.999254e-01 0.523
R-HSA-109582 Hemostasis 3.012250e-01 0.521
R-HSA-9610379 HCMV Late Events 3.038129e-01 0.517
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 3.057574e-01 0.515
R-HSA-9707616 Heme signaling 3.057574e-01 0.515
R-HSA-186797 Signaling by PDGF 3.057574e-01 0.515
R-HSA-181429 Serotonin Neurotransmitter Release Cycle 3.064331e-01 0.514
R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs 3.064331e-01 0.514
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants 3.064331e-01 0.514
R-HSA-210993 Tie2 Signaling 3.064331e-01 0.514
R-HSA-9711123 Cellular response to chemical stress 3.098762e-01 0.509
R-HSA-397014 Muscle contraction 3.100730e-01 0.509
R-HSA-373755 Semaphorin interactions 3.115803e-01 0.506
R-HSA-9006936 Signaling by TGFB family members 3.144816e-01 0.502
R-HSA-159424 Conjugation of carboxylic acids 3.173878e-01 0.498
R-HSA-156587 Amino Acid conjugation 3.173878e-01 0.498
R-HSA-844456 The NLRP3 inflammasome 3.173878e-01 0.498
R-HSA-392517 Rap1 signalling 3.173878e-01 0.498
R-HSA-9856532 Mechanical load activates signaling by PIEZO1 and integrins in osteocytes 3.173878e-01 0.498
R-HSA-2428924 IGF1R signaling cascade 3.173931e-01 0.498
R-HSA-74751 Insulin receptor signalling cascade 3.173931e-01 0.498
R-HSA-109581 Apoptosis 3.216130e-01 0.493
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 3.231945e-01 0.491
R-HSA-372790 Signaling by GPCR 3.235591e-01 0.490
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 3.241659e-01 0.489
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse 3.281702e-01 0.484
R-HSA-389513 Co-inhibition by CTLA4 3.281702e-01 0.484
R-HSA-140875 Common Pathway of Fibrin Clot Formation 3.281702e-01 0.484
R-HSA-9629569 Protein hydroxylation 3.281702e-01 0.484
R-HSA-418990 Adherens junctions interactions 3.286609e-01 0.483
R-HSA-5685942 HDR through Homologous Recombination (HRR) 3.347588e-01 0.475
R-HSA-5602498 MyD88 deficiency (TLR2/4) 3.387830e-01 0.470
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription 3.387830e-01 0.470
R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle 3.387830e-01 0.470
R-HSA-162594 Early Phase of HIV Life Cycle 3.387830e-01 0.470
R-HSA-167172 Transcription of the HIV genome 3.405198e-01 0.468
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 3.405198e-01 0.468
R-HSA-1592230 Mitochondrial biogenesis 3.457566e-01 0.461
R-HSA-5693538 Homology Directed Repair 3.500694e-01 0.456
R-HSA-2219528 PI3K/AKT Signaling in Cancer 3.500694e-01 0.456
R-HSA-204005 COPII-mediated vesicle transport 3.519943e-01 0.453
R-HSA-69202 Cyclin E associated events during G1/S transition 3.519943e-01 0.453
R-HSA-9764560 Regulation of CDH1 Gene Transcription 3.519943e-01 0.453
R-HSA-72306 tRNA processing 3.538152e-01 0.451
R-HSA-5621481 C-type lectin receptors (CLRs) 3.573980e-01 0.447
R-HSA-6803529 FGFR2 alternative splicing 3.595101e-01 0.444
R-HSA-212676 Dopamine Neurotransmitter Release Cycle 3.595101e-01 0.444
R-HSA-912694 Regulation of IFNA/IFNB signaling 3.595101e-01 0.444
R-HSA-2173788 Downregulation of TGF-beta receptor signaling 3.595101e-01 0.444
R-HSA-9924644 Developmental Lineages of the Mammary Gland 3.633996e-01 0.440
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 3.633996e-01 0.440
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 3.690741e-01 0.433
R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE 3.696296e-01 0.432
R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 3.696296e-01 0.432
R-HSA-977068 Termination of O-glycan biosynthesis 3.696296e-01 0.432
R-HSA-912526 Interleukin receptor SHC signaling 3.696296e-01 0.432
R-HSA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling 3.696296e-01 0.432
R-HSA-9937008 Mitochondrial mRNA modification 3.696296e-01 0.432
R-HSA-982772 Growth hormone receptor signaling 3.696296e-01 0.432
R-HSA-9694516 SARS-CoV-2 Infection 3.719650e-01 0.429
R-HSA-9013694 Signaling by NOTCH4 3.747287e-01 0.426
R-HSA-9821993 Replacement of protamines by nucleosomes in the male pronucleus 3.795899e-01 0.421
R-HSA-9703648 Signaling by FLT3 ITD and TKD mutants 3.795899e-01 0.421
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle 3.795899e-01 0.421
R-HSA-5621575 CD209 (DC-SIGN) signaling 3.795899e-01 0.421
R-HSA-9836573 Mitochondrial RNA degradation 3.795899e-01 0.421
R-HSA-9865881 Complex III assembly 3.795899e-01 0.421
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 3.803626e-01 0.420
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 3.844243e-01 0.415
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 3.844243e-01 0.415
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 3.844243e-01 0.415
R-HSA-1980143 Signaling by NOTCH1 3.859752e-01 0.413
R-HSA-5218921 VEGFR2 mediated cell proliferation 3.893934e-01 0.410
R-HSA-1660516 Synthesis of PIPs at the early endosome membrane 3.893934e-01 0.410
R-HSA-400685 Sema4D in semaphorin signaling 3.893934e-01 0.410
R-HSA-2559583 Cellular Senescence 3.896009e-01 0.409
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 3.915656e-01 0.407
R-HSA-216083 Integrin cell surface interactions 3.971332e-01 0.401
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 3.990426e-01 0.399
R-HSA-210500 Glutamate Neurotransmitter Release Cycle 3.990426e-01 0.399
R-HSA-525793 Myogenesis 3.990426e-01 0.399
R-HSA-9703465 Signaling by FLT3 fusion proteins 3.990426e-01 0.399
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 3.990426e-01 0.399
R-HSA-5689901 Metalloprotease DUBs 3.990426e-01 0.399
R-HSA-9845614 Sphingolipid catabolism 3.990426e-01 0.399
R-HSA-9659379 Sensory processing of sound 4.026773e-01 0.395
R-HSA-199418 Negative regulation of the PI3K/AKT network 4.056941e-01 0.392
R-HSA-446203 Asparagine N-linked glycosylation 4.077224e-01 0.390
R-HSA-5654738 Signaling by FGFR2 4.081972e-01 0.389
R-HSA-6806834 Signaling by MET 4.081972e-01 0.389
R-HSA-73863 RNA Polymerase I Transcription Termination 4.085399e-01 0.389
R-HSA-8949613 Cristae formation 4.085399e-01 0.389
R-HSA-201451 Signaling by BMP 4.085399e-01 0.389
R-HSA-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol 4.085399e-01 0.389
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 4.085399e-01 0.389
R-HSA-1474165 Reproduction 4.099235e-01 0.387
R-HSA-977225 Amyloid fiber formation 4.136924e-01 0.383
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 4.136924e-01 0.383
R-HSA-167287 HIV elongation arrest and recovery 4.178877e-01 0.379
R-HSA-167290 Pausing and recovery of HIV elongation 4.178877e-01 0.379
R-HSA-113418 Formation of the Early Elongation Complex 4.178877e-01 0.379
R-HSA-5205685 PINK1-PRKN Mediated Mitophagy 4.178877e-01 0.379
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex 4.178877e-01 0.379
R-HSA-77387 Insulin receptor recycling 4.178877e-01 0.379
R-HSA-622312 Inflammasomes 4.178877e-01 0.379
R-HSA-5654732 Negative regulation of FGFR3 signaling 4.178877e-01 0.379
R-HSA-9707564 Cytoprotection by HMOX1 4.246061e-01 0.372
R-HSA-72086 mRNA Capping 4.270883e-01 0.369
R-HSA-9759475 Regulation of CDH11 Expression and Function 4.270883e-01 0.369
R-HSA-5654733 Negative regulation of FGFR4 signaling 4.270883e-01 0.369
R-HSA-392154 Nitric oxide stimulates guanylate cyclase 4.270883e-01 0.369
R-HSA-418360 Platelet calcium homeostasis 4.270883e-01 0.369
R-HSA-9674555 Signaling by CSF3 (G-CSF) 4.270883e-01 0.369
R-HSA-210745 Regulation of gene expression in beta cells 4.270883e-01 0.369
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 4.300236e-01 0.367
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 4.300236e-01 0.367
R-HSA-421270 Cell-cell junction organization 4.316621e-01 0.365
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription 4.361440e-01 0.360
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 4.361440e-01 0.360
R-HSA-888590 GABA synthesis, release, reuptake and degradation 4.361440e-01 0.360
R-HSA-8863795 Downregulation of ERBB2 signaling 4.361440e-01 0.360
R-HSA-9008059 Interleukin-37 signaling 4.361440e-01 0.360
R-HSA-114452 Activation of BH3-only proteins 4.361440e-01 0.360
R-HSA-72163 mRNA Splicing - Major Pathway 4.391858e-01 0.357
R-HSA-162588 Budding and maturation of HIV virion 4.450572e-01 0.352
R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation 4.450572e-01 0.352
R-HSA-2129379 Molecules associated with elastic fibres 4.450572e-01 0.352
R-HSA-186763 Downstream signal transduction 4.450572e-01 0.352
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 4.461120e-01 0.351
R-HSA-163841 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 4.461120e-01 0.351
R-HSA-70268 Pyruvate metabolism 4.514186e-01 0.345
R-HSA-9675126 Diseases of mitotic cell cycle 4.538300e-01 0.343
R-HSA-350562 Regulation of ornithine decarboxylase (ODC) 4.538300e-01 0.343
R-HSA-4791275 Signaling by WNT in cancer 4.538300e-01 0.343
R-HSA-1236974 ER-Phagosome pathway 4.619448e-01 0.335
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 4.624646e-01 0.335
R-HSA-1839124 FGFR1 mutant receptor activation 4.624646e-01 0.335
R-HSA-6804758 Regulation of TP53 Activity through Acetylation 4.624646e-01 0.335
R-HSA-5654726 Negative regulation of FGFR1 signaling 4.624646e-01 0.335
R-HSA-159418 Recycling of bile acids and salts 4.624646e-01 0.335
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol 4.624646e-01 0.335
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis 4.709633e-01 0.327
R-HSA-114508 Effects of PIP2 hydrolysis 4.709633e-01 0.327
R-HSA-180534 Vpu mediated degradation of CD4 4.709633e-01 0.327
R-HSA-416476 G alpha (q) signalling events 4.715960e-01 0.326
R-HSA-8856828 Clathrin-mediated endocytosis 4.720741e-01 0.326
R-HSA-9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 4.723524e-01 0.326
R-HSA-72172 mRNA Splicing 4.773271e-01 0.321
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 4.775108e-01 0.321
R-HSA-1980145 Signaling by NOTCH2 4.793281e-01 0.319
R-HSA-5205647 Mitophagy 4.793281e-01 0.319
R-HSA-9680350 Signaling by CSF1 (M-CSF) in myeloid cells 4.793281e-01 0.319
R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D 4.793281e-01 0.319
R-HSA-5654727 Negative regulation of FGFR2 signaling 4.793281e-01 0.319
R-HSA-5686938 Regulation of TLR by endogenous ligand 4.793281e-01 0.319
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 4.793281e-01 0.319
R-HSA-5357801 Programmed Cell Death 4.807475e-01 0.318
R-HSA-2682334 EPH-Ephrin signaling 4.826385e-01 0.316
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 4.875612e-01 0.312
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 4.875612e-01 0.312
R-HSA-169911 Regulation of Apoptosis 4.875612e-01 0.312
R-HSA-2559585 Oncogene Induced Senescence 4.875612e-01 0.312
R-HSA-9837999 Mitochondrial protein degradation 4.928005e-01 0.307
R-HSA-1474290 Collagen formation 4.928005e-01 0.307
R-HSA-9682385 FLT3 signaling in disease 4.956646e-01 0.305
R-HSA-180585 Vif-mediated degradation of APOBEC3G 4.956646e-01 0.305
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 4.956646e-01 0.305
R-HSA-9845576 Glycosphingolipid transport 4.956646e-01 0.305
R-HSA-140877 Formation of Fibrin Clot (Clotting Cascade) 4.956646e-01 0.305
R-HSA-9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... 4.978342e-01 0.303
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 4.978342e-01 0.303
R-HSA-9679191 Potential therapeutics for SARS 5.000655e-01 0.301
R-HSA-9856651 MITF-M-dependent gene expression 5.000655e-01 0.301
R-HSA-72764 Eukaryotic Translation Termination 5.028361e-01 0.299
R-HSA-72689 Formation of a pool of free 40S subunits 5.028361e-01 0.299
R-HSA-4641258 Degradation of DVL 5.036403e-01 0.298
R-HSA-4641257 Degradation of AXIN 5.036403e-01 0.298
R-HSA-9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 5.036403e-01 0.298
R-HSA-549127 SLC-mediated transport of organic cations 5.036403e-01 0.298
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 5.036403e-01 0.298
R-HSA-8948216 Collagen chain trimerization 5.036403e-01 0.298
R-HSA-9755511 KEAP1-NFE2L2 pathway 5.040034e-01 0.298
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 5.078058e-01 0.294
R-HSA-1296071 Potassium Channels 5.078058e-01 0.294
R-HSA-5607764 CLEC7A (Dectin-1) signaling 5.078058e-01 0.294
R-HSA-446652 Interleukin-1 family signaling 5.079255e-01 0.294
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 5.079255e-01 0.294
R-HSA-1566948 Elastic fibre formation 5.114904e-01 0.291
R-HSA-190236 Signaling by FGFR 5.176480e-01 0.286
R-HSA-9725554 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin 5.192168e-01 0.285
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 5.192168e-01 0.285
R-HSA-9929356 GSK3B-mediated proteasomal degradation of PD-L1(CD274) 5.192168e-01 0.285
R-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 5.192168e-01 0.285
R-HSA-9658195 Leishmania infection 5.223955e-01 0.282
R-HSA-9824443 Parasitic Infection Pathways 5.223955e-01 0.282
R-HSA-192105 Synthesis of bile acids and bile salts 5.225200e-01 0.282
R-HSA-193704 p75 NTR receptor-mediated signalling 5.225200e-01 0.282
R-HSA-9670095 Inhibition of DNA recombination at telomere 5.268215e-01 0.278
R-HSA-9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 5.268215e-01 0.278
R-HSA-9843743 Transcriptional regulation of brown and beige adipocyte differentiation 5.268215e-01 0.278
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 5.268215e-01 0.278
R-HSA-167169 HIV Transcription Elongation 5.268215e-01 0.278
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 5.268215e-01 0.278
R-HSA-1251985 Nuclear signaling by ERBB4 5.268215e-01 0.278
R-HSA-9604323 Negative regulation of NOTCH4 signaling 5.268215e-01 0.278
R-HSA-8941858 Regulation of RUNX3 expression and activity 5.268215e-01 0.278
R-HSA-451927 Interleukin-2 family signaling 5.268215e-01 0.278
R-HSA-2408557 Selenocysteine synthesis 5.321649e-01 0.274
R-HSA-9020702 Interleukin-1 signaling 5.321649e-01 0.274
R-HSA-5362768 Hh mutants are degraded by ERAD 5.343063e-01 0.272
R-HSA-9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274) 5.343063e-01 0.272
R-HSA-73817 Purine ribonucleoside monophosphate biosynthesis 5.343063e-01 0.272
R-HSA-5676590 NIK-->noncanonical NF-kB signaling 5.343063e-01 0.272
R-HSA-2559580 Oxidative Stress Induced Senescence 5.369374e-01 0.270
R-HSA-167162 RNA Polymerase II HIV Promoter Escape 5.416732e-01 0.266
R-HSA-167161 HIV Transcription Initiation 5.416732e-01 0.266
R-HSA-75953 RNA Polymerase II Transcription Initiation 5.416732e-01 0.266
R-HSA-9932298 Degradation of CRY and PER proteins 5.416732e-01 0.266
R-HSA-5610780 Degradation of GLI1 by the proteasome 5.416732e-01 0.266
R-HSA-3000480 Scavenging by Class A Receptors 5.416732e-01 0.266
R-HSA-5610783 Degradation of GLI2 by the proteasome 5.416732e-01 0.266
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome 5.416732e-01 0.266
R-HSA-5655302 Signaling by FGFR1 in disease 5.416732e-01 0.266
R-HSA-192823 Viral mRNA Translation 5.416765e-01 0.266
R-HSA-73762 RNA Polymerase I Transcription Initiation 5.489241e-01 0.260
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 5.489241e-01 0.260
R-HSA-400508 Incretin synthesis, secretion, and inactivation 5.489241e-01 0.260
R-HSA-5619507 Activation of HOX genes during differentiation 5.510539e-01 0.259
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 5.510539e-01 0.259
R-HSA-5696398 Nucleotide Excision Repair 5.556918e-01 0.255
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 5.556918e-01 0.255
R-HSA-73776 RNA Polymerase II Promoter Escape 5.560606e-01 0.255
R-HSA-5387390 Hh mutants abrogate ligand secretion 5.560606e-01 0.255
R-HSA-2173789 TGF-beta receptor signaling activates SMADs 5.560606e-01 0.255
R-HSA-5654743 Signaling by FGFR4 5.560606e-01 0.255
R-HSA-9637690 Response of Mtb to phagocytosis 5.560606e-01 0.255
R-HSA-9692914 SARS-CoV-1-host interactions 5.602959e-01 0.252
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 5.630847e-01 0.249
R-HSA-9907900 Proteasome assembly 5.630847e-01 0.249
R-HSA-5683826 Surfactant metabolism 5.630847e-01 0.249
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 5.648659e-01 0.248
R-HSA-9679506 SARS-CoV Infections 5.675850e-01 0.246
R-HSA-2672351 Stimuli-sensing channels 5.694019e-01 0.245
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 5.699981e-01 0.244
R-HSA-4608870 Asymmetric localization of PCP proteins 5.699981e-01 0.244
R-HSA-5678895 Defective CFTR causes cystic fibrosis 5.699981e-01 0.244
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 5.699981e-01 0.244
R-HSA-69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A 5.699981e-01 0.244
R-HSA-69613 p53-Independent G1/S DNA Damage Checkpoint 5.699981e-01 0.244
R-HSA-9824272 Somitogenesis 5.699981e-01 0.244
R-HSA-5654741 Signaling by FGFR3 5.699981e-01 0.244
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 5.699981e-01 0.244
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex 5.768025e-01 0.239
R-HSA-72165 mRNA Splicing - Minor Pathway 5.768025e-01 0.239
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 5.768025e-01 0.239
R-HSA-9664424 Cell recruitment (pro-inflammatory response) 5.768025e-01 0.239
R-HSA-9660826 Purinergic signaling in leishmaniasis infection 5.768025e-01 0.239
R-HSA-9861718 Regulation of pyruvate metabolism 5.768025e-01 0.239
R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade 5.768025e-01 0.239
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 5.783712e-01 0.238
R-HSA-166166 MyD88-independent TLR4 cascade 5.783712e-01 0.238
R-HSA-194068 Bile acid and bile salt metabolism 5.783712e-01 0.238
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 5.791797e-01 0.237
R-HSA-418555 G alpha (s) signalling events 5.827474e-01 0.235
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 5.834996e-01 0.234
R-HSA-8939211 ESR-mediated signaling 5.847608e-01 0.233
R-HSA-927802 Nonsense-Mediated Decay (NMD) 5.872036e-01 0.231
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 5.872036e-01 0.231
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 5.898253e-01 0.229
R-HSA-9664433 Leishmania parasite growth and survival 5.898253e-01 0.229
R-HSA-5658442 Regulation of RAS by GAPs 6.029642e-01 0.220
R-HSA-2514856 The phototransduction cascade 6.092489e-01 0.215
R-HSA-1169091 Activation of NF-kappaB in B cells 6.092489e-01 0.215
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 6.092489e-01 0.215
R-HSA-5358346 Hedgehog ligand biogenesis 6.092489e-01 0.215
R-HSA-73772 RNA Polymerase I Promoter Escape 6.154344e-01 0.211
R-HSA-6794361 Neurexins and neuroligins 6.154344e-01 0.211
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 6.154344e-01 0.211
R-HSA-68949 Orc1 removal from chromatin 6.154344e-01 0.211
R-HSA-9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 6.154344e-01 0.211
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 6.154344e-01 0.211
R-HSA-5339562 Uptake and actions of bacterial toxins 6.154344e-01 0.211
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 6.215225e-01 0.207
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 6.215225e-01 0.207
R-HSA-9639288 Amino acids regulate mTORC1 6.215225e-01 0.207
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 6.215225e-01 0.207
R-HSA-8956320 Nucleotide biosynthesis 6.215225e-01 0.207
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 6.252506e-01 0.204
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 6.252506e-01 0.204
R-HSA-8878166 Transcriptional regulation by RUNX2 6.252506e-01 0.204
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 6.275145e-01 0.202
R-HSA-382551 Transport of small molecules 6.317370e-01 0.199
R-HSA-9012852 Signaling by NOTCH3 6.334121e-01 0.198
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 6.334121e-01 0.198
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 6.373169e-01 0.196
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 6.373169e-01 0.196
R-HSA-6798695 Neutrophil degranulation 6.384899e-01 0.195
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 6.392166e-01 0.194
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 6.392166e-01 0.194
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 6.392166e-01 0.194
R-HSA-5654736 Signaling by FGFR1 6.392166e-01 0.194
R-HSA-3299685 Detoxification of Reactive Oxygen Species 6.392166e-01 0.194
R-HSA-109606 Intrinsic Pathway for Apoptosis 6.392166e-01 0.194
R-HSA-8868773 rRNA processing in the nucleus and cytosol 6.404090e-01 0.194
R-HSA-388841 Regulation of T cell activation by CD28 family 6.405137e-01 0.193
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 6.412710e-01 0.193
R-HSA-5621480 Dectin-2 family 6.449295e-01 0.190
R-HSA-69206 G1/S Transition 6.529301e-01 0.185
R-HSA-9033241 Peroxisomal protein import 6.560865e-01 0.183
R-HSA-1474244 Extracellular matrix organization 6.574782e-01 0.182
R-HSA-114608 Platelet degranulation 6.605346e-01 0.180
R-HSA-8873719 RAB geranylgeranylation 6.615334e-01 0.179
R-HSA-351202 Metabolism of polyamines 6.615334e-01 0.179
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 6.615334e-01 0.179
R-HSA-168249 Innate Immune System 6.615555e-01 0.179
R-HSA-187037 Signaling by NTRK1 (TRKA) 6.642866e-01 0.178
R-HSA-211976 Endogenous sterols 6.668943e-01 0.176
R-HSA-8939902 Regulation of RUNX2 expression and activity 6.668943e-01 0.176
R-HSA-1442490 Collagen degradation 6.668943e-01 0.176
R-HSA-1268020 Mitochondrial protein import 6.721706e-01 0.173
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 6.721706e-01 0.173
R-HSA-9616222 Transcriptional regulation of granulopoiesis 6.721706e-01 0.173
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 6.721706e-01 0.173
R-HSA-6799198 Complex I biogenesis 6.773637e-01 0.169
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 6.773637e-01 0.169
R-HSA-8848021 Signaling by PTK6 6.773637e-01 0.169
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 6.773637e-01 0.169
R-HSA-9843745 Adipogenesis 6.789626e-01 0.168
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 6.824748e-01 0.166
R-HSA-1474228 Degradation of the extracellular matrix 6.825492e-01 0.166
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 6.861031e-01 0.164
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 6.864728e-01 0.163
R-HSA-1234174 Cellular response to hypoxia 6.875052e-01 0.163
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 6.924563e-01 0.160
R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 6.973293e-01 0.157
R-HSA-449147 Signaling by Interleukins 7.016888e-01 0.154
R-HSA-913709 O-linked glycosylation of mucins 7.021253e-01 0.154
R-HSA-1650814 Collagen biosynthesis and modifying enzymes 7.021253e-01 0.154
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 7.114914e-01 0.148
R-HSA-195253 Degradation of beta-catenin by the destruction complex 7.114914e-01 0.148
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 7.160638e-01 0.145
R-HSA-3906995 Diseases associated with O-glycosylation of proteins 7.160638e-01 0.145
R-HSA-453276 Regulation of mitotic cell cycle 7.160638e-01 0.145
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 7.160638e-01 0.145
R-HSA-5632684 Hedgehog 'on' state 7.160638e-01 0.145
R-HSA-9730414 MITF-M-regulated melanocyte development 7.173658e-01 0.144
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 7.205641e-01 0.142
R-HSA-69052 Switching of origins to a post-replicative state 7.249933e-01 0.140
R-HSA-9749641 Aspirin ADME 7.249933e-01 0.140
R-HSA-1236394 Signaling by ERBB4 7.293526e-01 0.137
R-HSA-1226099 Signaling by FGFR in disease 7.293526e-01 0.137
R-HSA-9006931 Signaling by Nuclear Receptors 7.299189e-01 0.137
R-HSA-8852135 Protein ubiquitination 7.336431e-01 0.135
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes 7.336431e-01 0.135
R-HSA-453279 Mitotic G1 phase and G1/S transition 7.355856e-01 0.133
R-HSA-73854 RNA Polymerase I Promoter Clearance 7.378658e-01 0.132
R-HSA-5689603 UCH proteinases 7.378658e-01 0.132
R-HSA-69242 S Phase 7.416579e-01 0.130
R-HSA-166520 Signaling by NTRKs 7.416579e-01 0.130
R-HSA-9758941 Gastrulation 7.446492e-01 0.128
R-HSA-383280 Nuclear Receptor transcription pathway 7.461121e-01 0.127
R-HSA-73864 RNA Polymerase I Transcription 7.461121e-01 0.127
R-HSA-5619084 ABC transporter disorders 7.461121e-01 0.127
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 7.501379e-01 0.125
R-HSA-9609507 Protein localization 7.563202e-01 0.121
R-HSA-1989781 PPARA activates gene expression 7.619818e-01 0.118
R-HSA-72312 rRNA processing 7.651132e-01 0.116
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 7.656150e-01 0.116
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 7.675294e-01 0.115
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 7.702610e-01 0.113
R-HSA-5687128 MAPK6/MAPK4 signaling 7.729916e-01 0.112
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 7.765927e-01 0.110
R-HSA-381038 XBP1(S) activates chaperone genes 7.801369e-01 0.108
R-HSA-157118 Signaling by NOTCH 7.831709e-01 0.106
R-HSA-2408522 Selenoamino acid metabolism 7.860715e-01 0.105
R-HSA-112310 Neurotransmitter release cycle 7.937624e-01 0.100
R-HSA-202424 Downstream TCR signaling 7.937624e-01 0.100
R-HSA-1912408 Pre-NOTCH Transcription and Translation 7.970352e-01 0.099
R-HSA-381070 IRE1alpha activates chaperones 8.002563e-01 0.097
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... 8.065465e-01 0.093
R-HSA-68867 Assembly of the pre-replicative complex 8.065465e-01 0.093
R-HSA-9909648 Regulation of PD-L1(CD274) expression 8.079979e-01 0.093
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 8.096172e-01 0.092
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 8.125913e-01 0.090
R-HSA-9678108 SARS-CoV-1 Infection 8.148512e-01 0.089
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization 8.185411e-01 0.087
R-HSA-157579 Telomere Maintenance 8.214222e-01 0.085
R-HSA-975871 MyD88 cascade initiated on plasma membrane 8.242576e-01 0.084
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 8.242576e-01 0.084
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 8.242576e-01 0.084
R-HSA-9734767 Developmental Cell Lineages 8.287992e-01 0.082
R-HSA-9937383 Mitochondrial ribosome-associated quality control 8.377762e-01 0.077
R-HSA-9833110 RSV-host interactions 8.428890e-01 0.074
R-HSA-69239 Synthesis of DNA 8.502587e-01 0.070
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 8.502587e-01 0.070
R-HSA-9700206 Signaling by ALK in cancer 8.502587e-01 0.070
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 8.526379e-01 0.069
R-HSA-975155 MyD88 dependent cascade initiated on endosome 8.549795e-01 0.068
R-HSA-69002 DNA Replication Pre-Initiation 8.549795e-01 0.068
R-HSA-202403 TCR signaling 8.572840e-01 0.067
R-HSA-389948 Co-inhibition by PD-1 8.639656e-01 0.064
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 8.639810e-01 0.063
R-HSA-1912422 Pre-NOTCH Expression and Processing 8.639810e-01 0.063
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 8.703648e-01 0.060
R-HSA-2871809 FCERI mediated Ca+2 mobilization 8.724257e-01 0.059
R-HSA-2029485 Role of phospholipids in phagocytosis 8.724257e-01 0.059
R-HSA-909733 Interferon alpha/beta signaling 8.724257e-01 0.059
R-HSA-2980736 Peptide hormone metabolism 8.764502e-01 0.057
R-HSA-1483257 Phospholipid metabolism 8.784774e-01 0.056
R-HSA-73886 Chromosome Maintenance 8.841236e-01 0.053
R-HSA-9635486 Infection with Mycobacterium tuberculosis 8.841236e-01 0.053
R-HSA-9759194 Nuclear events mediated by NFE2L2 8.841236e-01 0.053
R-HSA-9717207 Sensory perception of sweet, bitter, and umami (glutamate) taste 8.877803e-01 0.052
R-HSA-6809371 Formation of the cornified envelope 8.895654e-01 0.051
R-HSA-9824439 Bacterial Infection Pathways 8.935276e-01 0.049
R-HSA-9664323 FCGR3A-mediated IL10 synthesis 8.947526e-01 0.048
R-HSA-8951664 Neddylation 8.970174e-01 0.047
R-HSA-9717189 Sensory perception of taste 9.044101e-01 0.044
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 9.070668e-01 0.042
R-HSA-9018519 Estrogen-dependent gene expression 9.131846e-01 0.039
R-HSA-5173105 O-linked glycosylation 9.145669e-01 0.039
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 9.145669e-01 0.039
R-HSA-5368287 Mitochondrial translation 9.159273e-01 0.038
R-HSA-9664407 Parasite infection 9.185837e-01 0.037
R-HSA-9664422 FCGR3A-mediated phagocytosis 9.185837e-01 0.037
R-HSA-9664417 Leishmania phagocytosis 9.185837e-01 0.037
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 9.198803e-01 0.036
R-HSA-2871837 FCERI mediated NF-kB activation 9.248646e-01 0.034
R-HSA-1428517 Aerobic respiration and respiratory electron transport 9.275474e-01 0.033
R-HSA-2187338 Visual phototransduction 9.283989e-01 0.032
R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors 9.317676e-01 0.031
R-HSA-69306 DNA Replication 9.349785e-01 0.029
R-HSA-211897 Cytochrome P450 - arranged by substrate type 9.480821e-01 0.023
R-HSA-611105 Respiratory electron transport 9.571973e-01 0.019
R-HSA-3781865 Diseases of glycosylation 9.611380e-01 0.017
R-HSA-375276 Peptide ligand-binding receptors 9.623696e-01 0.017
R-HSA-425407 SLC-mediated transmembrane transport 9.630761e-01 0.016
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 9.658358e-01 0.015
R-HSA-500792 GPCR ligand binding 9.669071e-01 0.015
R-HSA-428157 Sphingolipid metabolism 9.704478e-01 0.013
R-HSA-6805567 Keratinization 9.731723e-01 0.012
R-HSA-8957322 Metabolism of steroids 9.738205e-01 0.012
R-HSA-9748784 Drug ADME 9.778935e-01 0.010
R-HSA-15869 Metabolism of nucleotides 9.834687e-01 0.007
R-HSA-202733 Cell surface interactions at the vascular wall 9.837336e-01 0.007
R-HSA-156580 Phase II - Conjugation of compounds 9.842508e-01 0.007
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 9.902793e-01 0.004
R-HSA-211945 Phase I - Functionalization of compounds 9.916198e-01 0.004
R-HSA-71291 Metabolism of amino acids and derivatives 9.917388e-01 0.004
R-HSA-5668914 Diseases of metabolism 9.939259e-01 0.003
R-HSA-211859 Biological oxidations 9.984968e-01 0.001
R-HSA-556833 Metabolism of lipids 9.999934e-01 0.000
R-HSA-381753 Olfactory Signaling Pathway 9.999995e-01 0.000
R-HSA-1430728 Metabolism 9.999997e-01 0.000
R-HSA-9709957 Sensory Perception 9.999998e-01 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
GAKGAK 0.784 0.099 1 0.877
ALPHAK3ALPHAK3 0.781 0.137 -1 0.788
TTKTTK 0.779 0.129 -2 0.890
CK1DCK1D 0.776 0.444 -3 0.776
BMPR1BBMPR1B 0.775 0.207 1 0.841
TAK1TAK1 0.774 0.050 1 0.848
MEKK3MEKK3 0.771 0.262 1 0.827
ALK2ALK2 0.770 0.127 -2 0.867
OSR1OSR1 0.770 0.069 2 0.799
ALK4ALK4 0.770 0.100 -2 0.861
MEKK2MEKK2 0.769 0.129 2 0.819
ACVR2BACVR2B 0.768 0.165 -2 0.868
VRK2VRK2 0.767 -0.088 1 0.897
EEF2KEEF2K 0.767 0.046 3 0.819
GRK7GRK7 0.767 0.201 1 0.785
ACVR2AACVR2A 0.767 0.175 -2 0.857
BMPR2BMPR2 0.766 0.071 -2 0.875
MOSMOS 0.766 0.157 1 0.923
BMPR1ABMPR1A 0.765 0.176 1 0.827
MST2MST2 0.765 0.002 1 0.827
CK1A2CK1A2 0.764 0.421 -3 0.771
GCKGCK 0.764 0.014 1 0.812
MEK1MEK1 0.763 0.021 2 0.849
VRK1VRK1 0.763 -0.083 2 0.872
MINKMINK 0.762 -0.009 1 0.813
PKRPKR 0.761 -0.045 1 0.863
TGFBR1TGFBR1 0.761 0.078 -2 0.852
TNIKTNIK 0.759 -0.032 3 0.857
BRAFBRAF 0.758 -0.058 -4 0.757
MEK5MEK5 0.758 -0.020 2 0.837
CK1ECK1E 0.757 0.430 -3 0.781
DLKDLK 0.757 0.078 1 0.860
STLK3STLK3 0.757 -0.033 1 0.778
ASK1ASK1 0.756 -0.087 1 0.788
GRK6GRK6 0.756 0.223 1 0.866
PASKPASK 0.756 0.017 -3 0.475
PDK1PDK1 0.756 -0.035 1 0.819
NEK5NEK5 0.755 -0.052 1 0.851
MST1MST1 0.755 -0.074 1 0.809
PRP4PRP4 0.755 0.007 -3 0.468
TAO3TAO3 0.755 0.013 1 0.818
ANKRD3ANKRD3 0.754 0.008 1 0.881
PRPKPRPK 0.754 -0.022 -1 0.824
LRRK2LRRK2 0.754 -0.139 2 0.853
MST3MST3 0.753 0.049 2 0.817
NEK8NEK8 0.753 -0.005 2 0.831
LATS1LATS1 0.753 -0.027 -3 0.424
GRK5GRK5 0.753 0.194 -3 0.598
MAP3K15MAP3K15 0.752 -0.061 1 0.799
YSK4YSK4 0.752 0.004 1 0.802
NEK11NEK11 0.752 -0.018 1 0.810
HPK1HPK1 0.751 -0.007 1 0.793
CAMKK1CAMKK1 0.751 -0.093 -2 0.707
KHS2KHS2 0.751 -0.003 1 0.800
MEKK1MEKK1 0.751 -0.061 1 0.841
PLK1PLK1 0.751 0.083 -2 0.857
NEK1NEK1 0.750 -0.153 1 0.827
HGKHGK 0.750 -0.068 3 0.846
NIKNIK 0.750 -0.121 -3 0.469
ZAKZAK 0.750 0.013 1 0.819
GRK1GRK1 0.750 0.257 -2 0.821
CK1G3CK1G3 0.750 0.426 -3 0.742
TAO2TAO2 0.749 -0.098 2 0.852
KHS1KHS1 0.748 -0.058 1 0.794
DAPK2DAPK2 0.748 -0.100 -3 0.447
TLK1TLK1 0.748 0.056 -2 0.892
GRK2GRK2 0.748 0.129 -2 0.748
LKB1LKB1 0.747 -0.118 -3 0.440
ATRATR 0.747 0.012 1 0.839
CAMKK2CAMKK2 0.747 -0.118 -2 0.692
MYO3AMYO3A 0.747 -0.057 1 0.795
COTCOT 0.746 0.159 2 0.871
BIKEBIKE 0.746 -0.037 1 0.755
MPSK1MPSK1 0.746 -0.018 1 0.816
MLK1MLK1 0.746 0.115 2 0.813
CAMLCKCAMLCK 0.745 -0.100 -2 0.761
TLK2TLK2 0.744 0.046 1 0.811
JNK3JNK3 0.744 0.030 1 0.656
PERKPERK 0.743 -0.026 -2 0.875
MYO3BMYO3B 0.742 -0.094 2 0.825
NLKNLK 0.742 -0.020 1 0.841
MEKK6MEKK6 0.741 -0.136 1 0.831
MEK2MEK2 0.741 -0.168 2 0.835
GRK3GRK3 0.741 0.188 -2 0.727
CDKL1CDKL1 0.740 -0.061 -3 0.417
GRK4GRK4 0.740 0.222 -2 0.876
CAMK1BCAMK1B 0.740 -0.099 -3 0.450
NEK4NEK4 0.740 -0.140 1 0.810
PBKPBK 0.740 -0.055 1 0.807
JNK2JNK2 0.738 0.016 1 0.616
DAPK3DAPK3 0.738 -0.062 -3 0.406
DSTYKDSTYK 0.737 0.057 2 0.862
YSK1YSK1 0.737 -0.110 2 0.805
CAMK2GCAMK2G 0.736 0.001 2 0.806
HRIHRI 0.736 -0.095 -2 0.864
MLK2MLK2 0.736 -0.084 2 0.819
P38BP38B 0.735 0.024 1 0.639
SKMLCKSKMLCK 0.735 -0.024 -2 0.782
RAF1RAF1 0.735 -0.048 1 0.866
P38AP38A 0.735 -0.001 1 0.713
CHAK2CHAK2 0.734 0.021 -1 0.748
MLK4MLK4 0.734 0.067 2 0.726
CK1G2CK1G2 0.734 0.365 -3 0.761
ERK5ERK5 0.733 0.003 1 0.833
ICKICK 0.733 -0.063 -3 0.432
PLK2PLK2 0.732 0.038 -3 0.512
SMMLCKSMMLCK 0.732 -0.113 -3 0.410
DMPK1DMPK1 0.731 -0.086 -3 0.372
ROCK2ROCK2 0.731 -0.077 -3 0.387
CDC7CDC7 0.730 0.065 1 0.898
PLK3PLK3 0.730 0.000 2 0.775
CLK3CLK3 0.730 0.070 1 0.844
NEK9NEK9 0.730 -0.104 2 0.841
AAK1AAK1 0.730 -0.029 1 0.649
DAPK1DAPK1 0.730 -0.040 -3 0.412
MASTLMASTL 0.730 -0.117 -2 0.785
P38DP38D 0.729 0.050 1 0.562
PDHK4PDHK4 0.729 -0.126 1 0.876
TGFBR2TGFBR2 0.727 0.016 -2 0.867
MLK3MLK3 0.727 0.014 2 0.739
CDK1CDK1 0.726 0.062 1 0.627
ATMATM 0.725 0.012 1 0.773
P38GP38G 0.725 0.028 1 0.540
LOKLOK 0.725 -0.128 -2 0.686
PIM3PIM3 0.725 -0.038 -3 0.446
JNK1JNK1 0.724 0.021 1 0.603
SLKSLK 0.724 -0.062 -2 0.660
RIPK3RIPK3 0.723 -0.023 3 0.694
PDHK1PDHK1 0.723 -0.152 1 0.867
NEK7NEK7 0.723 -0.029 -3 0.476
PIM1PIM1 0.722 -0.043 -3 0.418
IKKBIKKB 0.722 0.137 -2 0.712
RIPK1RIPK1 0.721 -0.110 1 0.835
KISKIS 0.721 0.214 1 0.701
MTORMTOR 0.721 -0.013 1 0.803
PINK1PINK1 0.720 -0.075 1 0.842
SMG1SMG1 0.720 -0.012 1 0.784
TTBK2TTBK2 0.719 0.016 2 0.710
ERK2ERK2 0.719 -0.006 1 0.671
CK1ACK1A 0.719 0.404 -3 0.760
PKN3PKN3 0.719 -0.100 -3 0.421
HIPK1HIPK1 0.719 -0.015 1 0.725
NEK6NEK6 0.719 -0.010 -2 0.879
HASPINHASPIN 0.719 -0.038 -1 0.575
CK1G1CK1G1 0.719 0.374 -3 0.770
TAO1TAO1 0.719 -0.127 1 0.750
TBK1TBK1 0.718 -0.016 1 0.762
WNK4WNK4 0.718 -0.141 -2 0.778
CK2A2CK2A2 0.718 0.129 1 0.780
CDKL5CDKL5 0.717 -0.049 -3 0.398
ERK1ERK1 0.717 0.022 1 0.627
TSSK2TSSK2 0.717 -0.119 -5 0.363
SRPK3SRPK3 0.716 -0.015 -3 0.395
IRAK4IRAK4 0.715 -0.118 1 0.826
AMPKA1AMPKA1 0.715 -0.103 -3 0.429
DYRK2DYRK2 0.714 -0.011 1 0.706
WNK1WNK1 0.714 -0.113 -2 0.782
IKKAIKKA 0.714 0.051 -2 0.724
GSK3AGSK3A 0.714 0.008 4 0.423
IKKEIKKE 0.714 -0.020 1 0.759
NUAK2NUAK2 0.714 -0.088 -3 0.434
NEK2NEK2 0.714 -0.167 2 0.818
CDK5CDK5 0.713 -0.003 1 0.695
ROCK1ROCK1 0.713 -0.094 -3 0.359
GSK3BGSK3B 0.713 -0.013 4 0.412
HUNKHUNK 0.712 -0.111 2 0.814
PIM2PIM2 0.712 -0.089 -3 0.353
ULK2ULK2 0.712 -0.125 2 0.816
MRCKAMRCKA 0.712 -0.095 -3 0.355
MAKMAK 0.712 -0.020 -2 0.652
DNAPKDNAPK 0.712 -0.050 1 0.694
DCAMKL1DCAMKL1 0.712 -0.120 -3 0.373
BUB1BUB1 0.711 -0.089 -5 0.338
CK2A1CK2A1 0.711 0.133 1 0.757
PKN2PKN2 0.711 -0.093 -3 0.436
DRAK1DRAK1 0.710 -0.074 1 0.777
P70S6KBP70S6KB 0.710 -0.103 -3 0.386
NEK3NEK3 0.710 -0.200 1 0.796
MST4MST4 0.710 -0.056 2 0.825
PKCDPKCD 0.709 -0.096 2 0.798
CHAK1CHAK1 0.709 -0.100 2 0.782
CAMK2BCAMK2B 0.709 -0.019 2 0.761
PDHK1_TYRPDHK1_TYR 0.708 0.225 -1 0.879
CDK2CDK2 0.707 0.001 1 0.710
CHK1CHK1 0.707 -0.201 -3 0.366
CAMK2DCAMK2D 0.707 -0.112 -3 0.401
MYLK4MYLK4 0.707 -0.071 -2 0.673
CLK4CLK4 0.707 -0.042 -3 0.396
MAP2K6_TYRMAP2K6_TYR 0.707 0.228 -1 0.850
ERK7ERK7 0.707 -0.022 2 0.521
WNK3WNK3 0.707 -0.165 1 0.840
CRIKCRIK 0.706 -0.105 -3 0.321
DYRK1ADYRK1A 0.705 -0.051 1 0.744
IRE1IRE1 0.705 -0.060 1 0.814
IRE2IRE2 0.705 -0.087 2 0.806
SGK3SGK3 0.705 -0.093 -3 0.365
MRCKBMRCKB 0.705 -0.100 -3 0.347
SRPK1SRPK1 0.704 -0.029 -3 0.387
HIPK4HIPK4 0.704 -0.037 1 0.801
HIPK3HIPK3 0.704 -0.053 1 0.724
BMPR2_TYRBMPR2_TYR 0.704 0.111 -1 0.867
IRAK1IRAK1 0.704 -0.169 -1 0.661
MARK4MARK4 0.704 -0.122 4 0.774
MAP2K4_TYRMAP2K4_TYR 0.703 0.137 -1 0.848
YANK2YANK2 0.703 0.101 2 0.404
RIPK2RIPK2 0.703 -0.146 1 0.771
DCAMKL2DCAMKL2 0.703 -0.138 -3 0.375
ULK1ULK1 0.703 -0.099 -3 0.457
GCN2GCN2 0.702 -0.063 2 0.808
CDK3CDK3 0.702 0.035 1 0.565
SGK1SGK1 0.702 -0.072 -3 0.283
PDHK4_TYRPDHK4_TYR 0.702 0.170 2 0.873
TSSK1TSSK1 0.702 -0.133 -3 0.429
CAMK4CAMK4 0.702 -0.126 -3 0.416
YANK3YANK3 0.702 0.074 2 0.387
PDHK3_TYRPDHK3_TYR 0.701 0.025 4 0.872
MOKMOK 0.701 -0.055 1 0.746
AKT2AKT2 0.701 -0.072 -3 0.328
PLK4PLK4 0.701 -0.040 2 0.683
CDK14CDK14 0.700 -0.029 1 0.645
AMPKA2AMPKA2 0.700 -0.119 -3 0.396
PAK2PAK2 0.700 -0.092 -2 0.657
SYKSYK 0.699 0.214 -1 0.847
CAMK2ACAMK2A 0.699 -0.059 2 0.772
RSK2RSK2 0.699 -0.075 -3 0.366
CHK2CHK2 0.699 -0.110 -3 0.282
CDK8CDK8 0.698 -0.019 1 0.676
P90RSKP90RSK 0.697 -0.099 -3 0.373
PKCAPKCA 0.697 -0.089 2 0.736
DYRK1BDYRK1B 0.696 -0.043 1 0.653
DYRK3DYRK3 0.696 -0.047 1 0.730
HIPK2HIPK2 0.696 0.006 1 0.614
FGRFGR 0.696 0.106 1 0.883
CDK6CDK6 0.695 -0.033 1 0.627
PKCZPKCZ 0.695 -0.098 2 0.790
BCKDKBCKDK 0.695 -0.081 -1 0.728
TXKTXK 0.695 0.099 1 0.884
AURAAURA 0.695 -0.028 -2 0.538
NDR1NDR1 0.695 -0.120 -3 0.418
MAPKAPK3MAPKAPK3 0.695 -0.139 -3 0.342
PKCHPKCH 0.695 -0.109 2 0.743
LATS2LATS2 0.694 -0.087 -5 0.340
PKCBPKCB 0.694 -0.073 2 0.741
FAM20CFAM20C 0.694 0.069 2 0.599
CDK13CDK13 0.694 -0.026 1 0.648
CAMK1DCAMK1D 0.694 -0.126 -3 0.300
CDK17CDK17 0.693 -0.015 1 0.543
PAK1PAK1 0.693 -0.106 -2 0.670
STK33STK33 0.693 -0.082 2 0.622
TTBK1TTBK1 0.692 -0.037 2 0.631
EPHB4EPHB4 0.691 0.028 -1 0.864
NDR2NDR2 0.691 -0.073 -3 0.434
MAP2K7_TYRMAP2K7_TYR 0.691 -0.050 2 0.864
CLK1CLK1 0.691 -0.065 -3 0.353
MSK1MSK1 0.691 -0.074 -3 0.367
DYRK4DYRK4 0.691 -0.016 1 0.628
MELKMELK 0.691 -0.161 -3 0.366
AKT1AKT1 0.691 -0.079 -3 0.327
RSK4RSK4 0.691 -0.069 -3 0.360
EPHA6EPHA6 0.691 -0.005 -1 0.882
CDK18CDK18 0.691 -0.015 1 0.602
FLT1FLT1 0.690 0.156 -1 0.875
FERFER 0.690 0.050 1 0.904
ABL2ABL2 0.690 0.064 -1 0.819
LCKLCK 0.690 0.077 -1 0.845
QIKQIK 0.690 -0.149 -3 0.417
TESK1_TYRTESK1_TYR 0.690 -0.106 3 0.871
FYNFYN 0.690 0.110 -1 0.829
BLKBLK 0.689 0.098 -1 0.852
PKACGPKACG 0.689 -0.075 -2 0.644
SSTKSSTK 0.689 -0.103 4 0.743
NIM1NIM1 0.688 -0.127 3 0.750
PKMYT1_TYRPKMYT1_TYR 0.688 -0.118 3 0.832
PKCGPKCG 0.688 -0.090 2 0.738
CLK2CLK2 0.688 -0.003 -3 0.381
AURBAURB 0.688 -0.073 -2 0.550
HCKHCK 0.688 0.047 -1 0.836
MARK2MARK2 0.688 -0.116 4 0.672
SRPK2SRPK2 0.687 -0.040 -3 0.337
CDK12CDK12 0.687 -0.035 1 0.619
YES1YES1 0.687 0.034 -1 0.828
MAPKAPK2MAPKAPK2 0.687 -0.078 -3 0.330
CDK4CDK4 0.687 -0.054 1 0.604
MSK2MSK2 0.687 -0.094 -3 0.379
PINK1_TYRPINK1_TYR 0.686 -0.068 1 0.867
PKCEPKCE 0.686 -0.069 2 0.726
PAK3PAK3 0.686 -0.139 -2 0.662
CDK16CDK16 0.686 -0.028 1 0.563
INSRRINSRR 0.686 0.048 3 0.697
PRKD3PRKD3 0.685 -0.133 -3 0.338
ABL1ABL1 0.685 0.043 -1 0.804
CAMK1GCAMK1G 0.685 -0.127 -3 0.367
PRKD1PRKD1 0.685 -0.132 -3 0.378
KITKIT 0.685 0.068 3 0.755
QSKQSK 0.685 -0.112 4 0.749
ZAP70ZAP70 0.684 0.199 -1 0.747
EPHB2EPHB2 0.684 0.028 -1 0.860
METMET 0.684 0.086 3 0.747
SRMSSRMS 0.684 0.021 1 0.886
EPHA4EPHA4 0.683 0.003 2 0.761
CDK7CDK7 0.683 -0.059 1 0.680
RSK3RSK3 0.683 -0.120 -3 0.361
RETRET 0.683 -0.068 1 0.831
SBKSBK 0.683 -0.106 -3 0.233
CDK19CDK19 0.683 -0.017 1 0.633
PTK2PTK2 0.683 0.110 -1 0.829
CSF1RCSF1R 0.682 -0.008 3 0.750
PKG2PKG2 0.682 -0.086 -2 0.561
EPHB1EPHB1 0.682 0.005 1 0.881
JAK3JAK3 0.682 -0.009 1 0.820
MARK1MARK1 0.681 -0.138 4 0.721
PKACBPKACB 0.681 -0.060 -2 0.570
JAK2JAK2 0.680 -0.063 1 0.832
EPHB3EPHB3 0.680 -0.008 -1 0.851
P70S6KP70S6K 0.679 -0.124 -3 0.319
CAMK1ACAMK1A 0.679 -0.127 -3 0.291
BMXBMX 0.679 0.028 -1 0.760
CDK10CDK10 0.679 -0.035 1 0.629
PHKG1PHKG1 0.679 -0.114 -3 0.413
TYRO3TYRO3 0.679 -0.072 3 0.764
ITKITK 0.679 -0.022 -1 0.795
TYK2TYK2 0.678 -0.101 1 0.832
ROS1ROS1 0.678 -0.073 3 0.725
PKCIPKCI 0.678 -0.119 2 0.756
MARK3MARK3 0.678 -0.117 4 0.696
KDRKDR 0.678 0.028 3 0.707
NUAK1NUAK1 0.678 -0.139 -3 0.367
EGFREGFR 0.677 0.049 1 0.699
SRCSRC 0.677 0.064 -1 0.819
PKCTPKCT 0.677 -0.130 2 0.751
AURCAURC 0.677 -0.056 -2 0.550
MST1RMST1R 0.677 -0.102 3 0.773
CDK9CDK9 0.677 -0.073 1 0.655
MNK1MNK1 0.677 -0.116 -2 0.692
ERBB2ERBB2 0.676 0.029 1 0.786
LYNLYN 0.676 0.030 3 0.671
PRKD2PRKD2 0.676 -0.116 -3 0.334
FLT3FLT3 0.675 -0.022 3 0.755
LIMK2_TYRLIMK2_TYR 0.674 -0.181 -3 0.444
MNK2MNK2 0.674 -0.126 -2 0.678
FGFR2FGFR2 0.673 -0.050 3 0.751
FGFR3FGFR3 0.673 0.023 3 0.722
MERTKMERTK 0.673 -0.017 3 0.730
AKT3AKT3 0.673 -0.077 -3 0.289
SIKSIK 0.672 -0.131 -3 0.365
TECTEC 0.672 -0.015 -1 0.741
FGFR4FGFR4 0.672 0.056 -1 0.815
LIMK1_TYRLIMK1_TYR 0.672 -0.226 2 0.866
MAPKAPK5MAPKAPK5 0.671 -0.142 -3 0.331
MATKMATK 0.671 0.013 -1 0.758
FRKFRK 0.671 -0.002 -1 0.863
BTKBTK 0.671 -0.066 -1 0.752
EPHA5EPHA5 0.670 0.010 2 0.756
NTRK1NTRK1 0.670 -0.041 -1 0.824
EPHA3EPHA3 0.670 -0.036 2 0.745
EPHA7EPHA7 0.670 -0.031 2 0.775
SNRKSNRK 0.670 -0.178 2 0.735
ERBB4ERBB4 0.669 0.082 1 0.712
PTK6PTK6 0.669 -0.061 -1 0.719
DDR1DDR1 0.668 -0.168 4 0.777
PKACAPKACA 0.668 -0.079 -2 0.513
TNK2TNK2 0.668 -0.087 3 0.722
EPHA8EPHA8 0.668 -0.004 -1 0.851
BRSK1BRSK1 0.667 -0.123 -3 0.376
PDGFRBPDGFRB 0.667 -0.104 3 0.763
NTRK3NTRK3 0.667 -0.028 -1 0.792
WEE1_TYRWEE1_TYR 0.665 -0.029 -1 0.721
PRKXPRKX 0.665 -0.037 -3 0.328
JAK1JAK1 0.664 -0.085 1 0.772
TEKTEK 0.664 -0.119 3 0.690
FGFR1FGFR1 0.664 -0.103 3 0.721
BRSK2BRSK2 0.664 -0.154 -3 0.381
INSRINSR 0.664 -0.053 3 0.679
ALKALK 0.663 -0.071 3 0.666
FLT4FLT4 0.663 -0.044 3 0.702
EPHA2EPHA2 0.663 0.016 -1 0.841
PTK2BPTK2B 0.663 -0.027 -1 0.755
NTRK2NTRK2 0.662 -0.084 3 0.703
PKN1PKN1 0.662 -0.132 -3 0.323
LTKLTK 0.661 -0.079 3 0.694
IGF1RIGF1R 0.659 0.006 3 0.617
AXLAXL 0.659 -0.121 3 0.732
TNNI3K_TYRTNNI3K_TYR 0.658 -0.109 1 0.855
PDGFRAPDGFRA 0.658 -0.157 3 0.759
CSKCSK 0.658 -0.039 2 0.777
NEK10_TYRNEK10_TYR 0.655 -0.146 1 0.714
EPHA1EPHA1 0.654 -0.124 3 0.715
PAK6PAK6 0.653 -0.106 -2 0.569
PHKG2PHKG2 0.652 -0.151 -3 0.381
TNK1TNK1 0.651 -0.176 3 0.742
FESFES 0.648 -0.014 -1 0.727
DDR2DDR2 0.645 -0.115 3 0.687
MUSKMUSK 0.643 -0.091 1 0.686
PAK5PAK5 0.642 -0.116 -2 0.526
PKG1PKG1 0.634 -0.112 -2 0.469
PAK4PAK4 0.630 -0.109 -2 0.538