Motif 1002 (n=147)

Position-wise Probabilities
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uniprot genes site source protein function
O14523 C2CD2L T670 ochoa Phospholipid transfer protein C2CD2L (C2 domain-containing protein 2-like) (C2CD2-like) (Transmembrane protein 24) Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (PubMed:28209843). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (PubMed:28209843). Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers (PubMed:28209843). In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane (PubMed:28209843). Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules (PubMed:28209843). {ECO:0000269|PubMed:28209843}.
O14976 GAK T329 ochoa Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26) Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (PubMed:10625686). May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly (PubMed:18489706). {ECO:0000269|PubMed:10625686, ECO:0000269|PubMed:18489706}.
O15173 PGRMC2 T93 ochoa Membrane-associated progesterone receptor component 2 (Progesterone membrane-binding protein) (Steroid receptor protein DG6) Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus (By similarity). Plays a role in adipocyte function and systemic glucose homeostasis (PubMed:28111073). In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1 (By similarity). {ECO:0000250|UniProtKB:Q80UU9, ECO:0000269|PubMed:28111073, ECO:0000305|PubMed:28396637}.
O15409 FOXP2 T458 ochoa Forkhead box protein P2 (CAG repeat protein 44) (Trinucleotide repeat-containing gene 10 protein) Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language.
O43310 CTIF T302 ochoa CBP80/20-dependent translation initiation factor Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD). {ECO:0000269|PubMed:19648179}.
O75037 KIF21B T1244 ochoa Kinesin-like protein KIF21B Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation. Plays a role in lerning and memory. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptor to cell surface. {ECO:0000250|UniProtKB:Q9QXL1}.
O75132 ZBED4 T627 ochoa Zinc finger BED domain-containing protein 4 Transcriptional regulator that binds to poly-guanine tracts in gene promoters and activates transcription (By similarity). Able to bind single- and double-stranded DNA and RNA (By similarity). {ECO:0000250|UniProtKB:Q80WQ9}.
O75363 BCAS1 T66 ochoa Breast carcinoma-amplified sequence 1 (Amplified and overexpressed in breast cancer) (Novel amplified in breast cancer 1) Required for myelination. {ECO:0000250|UniProtKB:Q80YN3}.
O75369 FLNB T935 ochoa Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O75369 FLNB T1031 ochoa Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O75581 LRP6 T1493 ochoa|psp Low-density lipoprotein receptor-related protein 6 (LRP-6) Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes (PubMed:11357136, PubMed:11448771, PubMed:15778503, PubMed:16341017, PubMed:16513652, PubMed:17326769, PubMed:17400545, PubMed:19107203, PubMed:19293931, PubMed:19801552, PubMed:28341812). Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation (PubMed:11357136, PubMed:11448771, PubMed:15778503, PubMed:16341017, PubMed:16513652, PubMed:17326769, PubMed:17400545, PubMed:19107203, PubMed:19293931, PubMed:19801552, PubMed:28341812). The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalosomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin (PubMed:16513652). Required for posterior patterning of the epiblast during gastrulation (By similarity). {ECO:0000250|UniProtKB:O88572, ECO:0000269|PubMed:11357136, ECO:0000269|PubMed:11448771, ECO:0000269|PubMed:15778503, ECO:0000269|PubMed:16341017, ECO:0000269|PubMed:16513652, ECO:0000269|PubMed:17326769, ECO:0000269|PubMed:17400545, ECO:0000269|PubMed:19107203, ECO:0000269|PubMed:19293931, ECO:0000269|PubMed:19801552, ECO:0000269|PubMed:28341812}.
O76061 STC2 T254 ochoa Stanniocalcin-2 (STC-2) (Stanniocalcin-related protein) (STC-related protein) (STCRP) Has an anti-hypocalcemic action on calcium and phosphate homeostasis.
P05187 ALPP T117 ochoa Alkaline phosphatase, placental type (EC 3.1.3.1) (Alkaline phosphatase Regan isozyme) (Placental alkaline phosphatase 1) (PLAP-1) Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000269|PubMed:1939159, ECO:0000269|PubMed:25775211}.
P0DPH7 TUBA3C T51 ochoa Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P0DPH7 TUBA3C T94 ochoa Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P0DPH8 TUBA3D T51 ochoa Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P0DPH8 TUBA3D T94 ochoa Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P10244 MYBL2 T396 ochoa Myb-related protein B (B-Myb) (Myb-like protein 2) Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene. {ECO:0000269|PubMed:10770937}.
P10589 NR2F1 T66 ochoa COUP transcription factor 1 (COUP-TF1) (COUP transcription factor I) (COUP-TF I) (Nuclear receptor subfamily 2 group F member 1) (V-erbA-related protein 3) (EAR-3) Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG. {ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:11682620}.
P10696 ALPG T114 ochoa Alkaline phosphatase, germ cell type (EC 3.1.3.1) (ALP-1) (Alkaline phosphatase Nagao isozyme) (Alkaline phosphatase, placental-like) (Germ cell alkaline phosphatase) (GCAP) (Placental alkaline phosphatase-like) (PLAP-like) Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000269|PubMed:1939159}.
P15260 IFNGR1 T330 ochoa Interferon gamma receptor 1 (IFN-gamma receptor 1) (IFN-gamma-R1) (CDw119) (Interferon gamma receptor alpha-chain) (IFN-gamma-R-alpha) (CD antigen CD119) Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (PubMed:20015550). Associates with transmembrane accessory factor IFNGR2 to form a functional receptor (PubMed:10986460, PubMed:2971451, PubMed:7615558, PubMed:7617032, PubMed:7673114). Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to dimerization, translocation to the nucleus, and stimulation of target gene transcription (PubMed:28883123). STAT3 can also be activated in a similar manner although activation seems weaker. IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1 (By similarity). {ECO:0000250|UniProtKB:P15261, ECO:0000269|PubMed:10986460, ECO:0000269|PubMed:20015550, ECO:0000269|PubMed:28883123, ECO:0000269|PubMed:2971451, ECO:0000269|PubMed:7615558, ECO:0000269|PubMed:7617032, ECO:0000269|PubMed:7673114}.
P17096 HMGA1 T39 ochoa High mobility group protein HMG-I/HMG-Y (HMG-I(Y)) (High mobility group AT-hook protein 1) (High mobility group protein A1) (High mobility group protein R) HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.
P19438 TNFRSF1A T353 ochoa Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)] Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
P21291 CSRP1 T101 ochoa Cysteine and glycine-rich protein 1 (Cysteine-rich protein 1) (CRP) (CRP1) (Epididymis luminal protein 141) (HEL-141) Could play a role in neuronal development.
P21796 VDAC1 T107 ochoa|psp Non-selective voltage-gated ion channel VDAC1 (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM) (Voltage-dependent anion-selective channel protein 1) (VDAC-1) (hVDAC1) Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:30061676, PubMed:8420959). The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:8420959). It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (PubMed:10661876, PubMed:18755977, PubMed:8420959). The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:18755977, PubMed:8420959). Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (PubMed:18755977, PubMed:31015432). In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756). May mediate ATP export from cells (PubMed:30061676). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (By similarity). Mediates cytochrome c efflux (PubMed:20230784). {ECO:0000250|UniProtKB:Q60932, ECO:0000269|PubMed:10661876, ECO:0000269|PubMed:11845315, ECO:0000269|PubMed:15033708, ECO:0000269|PubMed:18755977, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:25296756, ECO:0000269|PubMed:30061676, ECO:0000269|PubMed:31015432, ECO:0000269|PubMed:32047033, ECO:0000269|PubMed:8420959}.; FUNCTION: Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids. {ECO:0000269|PubMed:38065946}.
P29474 NOS3 T60 ochoa Nitric oxide synthase 3 (EC 1.14.13.39) (Constitutive NOS) (cNOS) (EC-NOS) (NOS type III) (NOSIII) (Nitric oxide synthase, endothelial) (Endothelial NOS) (eNOS) Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway (PubMed:1378832). NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. {ECO:0000269|PubMed:1378832}.; FUNCTION: [Isoform eNOS13C]: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.
P31943 HNRNPH1 T107 ochoa Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed] This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:16946708}.
P32519 ELF1 T190 ochoa ETS-related transcription factor Elf-1 (E74-like factor 1) Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer. {ECO:0000269|PubMed:8756667}.
P33241 LSP1 T196 ochoa Lymphocyte-specific protein 1 (47 kDa actin-binding protein) (52 kDa phosphoprotein) (pp52) (Lymphocyte-specific antigen WP34) May play a role in mediating neutrophil activation and chemotaxis. {ECO:0000250}.
P35568 IRS1 T351 ochoa Insulin receptor substrate 1 (IRS-1) Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}.
P35869 AHR T697 psp Aryl hydrocarbon receptor (Ah receptor) (AhR) (Class E basic helix-loop-helix protein 76) (bHLHe76) Ligand-activated transcription factor that enables cells to adapt to changing conditions by sensing compounds from the environment, diet, microbiome and cellular metabolism, and which plays important roles in development, immunity and cancer (PubMed:23275542, PubMed:30373764, PubMed:32818467, PubMed:7961644). Upon ligand binding, translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE) (PubMed:23275542, PubMed:30373764, PubMed:7961644). Regulates a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (PubMed:12213388). Xenobiotics can act as ligands: upon xenobiotic-binding, activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) (PubMed:7961644, PubMed:33193710). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons (PubMed:34521881, PubMed:7961644). Next to xenobiotics, natural ligands derived from plants, microbiota, and endogenous metabolism are potent AHR agonists (PubMed:18076143). Tryptophan (Trp) derivatives constitute an important class of endogenous AHR ligands (PubMed:32818467, PubMed:32866000). Acts as a negative regulator of anti-tumor immunity: indoles and kynurenic acid generated by Trp catabolism act as ligand and activate AHR, thereby promoting AHR-driven cancer cell motility and suppressing adaptive immunity (PubMed:32818467). Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1 (PubMed:28602820). Inhibits PER1 by repressing the CLOCK-BMAL1 heterodimer mediated transcriptional activation of PER1 (PubMed:28602820). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820). {ECO:0000269|PubMed:23275542, ECO:0000269|PubMed:28602820, ECO:0000269|PubMed:30373764, ECO:0000269|PubMed:32818467, ECO:0000269|PubMed:32866000, ECO:0000269|PubMed:33193710, ECO:0000269|PubMed:34521881, ECO:0000269|PubMed:7961644, ECO:0000303|PubMed:12213388, ECO:0000303|PubMed:18076143}.
P42858 HTT T2654 ochoa Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment] [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function.; FUNCTION: [Huntingtin, myristoylated N-terminal fragment]: Promotes the formation of autophagic vesicles. {ECO:0000269|PubMed:24459296}.
P45880 VDAC2 T118 ochoa Non-selective voltage-gated ion channel VDAC2 (VDAC-2) (hVDAC2) (Outer mitochondrial membrane protein porin 2) Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:8420959). The channel adopts an open conformation at zero mV and a closed conformation at both positive and negative potentials (PubMed:8420959). There are two populations of channels; the main that functions in a lower open-state conductance with lower ion selectivity, that switch, in a voltage-dependent manner, from the open to a low-conducting 'closed' state and the other that has a normal ion selectivity in the typical high conductance, 'open' state (PubMed:8420959). Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (PubMed:31015432). Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway (PubMed:31015432). {ECO:0000269|PubMed:31015432, ECO:0000269|PubMed:8420959}.; FUNCTION: Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids. {ECO:0000269|PubMed:38065946}.
P49757 NUMB T250 ochoa Protein numb homolog (h-Numb) (Protein S171) Regulates clathrin-mediated receptor endocytosis (PubMed:18657069). Plays a role in the process of neurogenesis (By similarity). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity). May also mediate local repair of brain ventricular wall damage (By similarity). {ECO:0000250|UniProtKB:Q9QZS3, ECO:0000269|PubMed:18657069}.
P49815 TSC2 T667 ochoa Tuberin (Tuberous sclerosis 2 protein) Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250|UniProtKB:P49816, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12820960, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:33436626, ECO:0000269|PubMed:35772404}.
P55196 AFDN T249 ochoa Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}.
P55795 HNRNPH2 T107 ochoa Heterogeneous nuclear ribonucleoprotein H2 (hnRNP H2) (FTP-3) (Heterogeneous nuclear ribonucleoprotein H') (hnRNP H') [Cleaved into: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed] This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG).
P58012 FOXL2 T329 psp Forkhead box protein L2 Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. {ECO:0000250, ECO:0000269|PubMed:16153597, ECO:0000269|PubMed:19010791, ECO:0000269|PubMed:19429596, ECO:0000269|PubMed:19744555}.
P68363 TUBA1B T51 ochoa Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}.
P68363 TUBA1B T94 ochoa Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}.
P68366 TUBA4A T94 ochoa Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q01082 SPTBN1 T2335 ochoa Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}.
Q01094 E2F1 T344 ochoa Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1) Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication (PubMed:10675335, PubMed:12717439, PubMed:17050006, PubMed:17704056, PubMed:18625225, PubMed:28992046). The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase (PubMed:10675335, PubMed:12717439, PubMed:17704056). E2F1 binds preferentially RB1 in a cell-cycle dependent manner (PubMed:10675335, PubMed:12717439, PubMed:17704056). It can mediate both cell proliferation and TP53/p53-dependent apoptosis (PubMed:8170954). Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812). Directly activates transcription of PEG10 (PubMed:17050006, PubMed:18625225, PubMed:28992046). Positively regulates transcription of RRP1B (PubMed:20040599). {ECO:0000269|PubMed:10675335, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:17050006, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:18625225, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20176812, ECO:0000269|PubMed:28992046, ECO:0000269|PubMed:8170954}.
Q01130 SRSF2 T29 ochoa Serine/arginine-rich splicing factor 2 (Protein PR264) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2) Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment. {ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21157427}.
Q02880 TOP2B T1403 ochoa DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme) Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. {ECO:0000269|PubMed:10684600, ECO:0000269|PubMed:31409799, ECO:0000269|PubMed:32128574}.
Q02952 AKAP12 T289 ochoa A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).
Q02952 AKAP12 T1730 ochoa A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).
Q04637 EIF4G1 T211 ochoa Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}.
Q08AD1 CAMSAP2 T614 ochoa Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}.
Q12830 BPTF T2101 ochoa Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013). {ECO:0000269|PubMed:10575013, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:16728976, ECO:0000269|PubMed:16728978, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:28801535}.
Q13045 FLII T409 ochoa Protein flightless-1 homolog Is a regulator of actin polymerization, required for proper myofibril organization and regulation of the length of sarcomeric thin filaments (By similarity). It also plays a role in the assembly of cardiomyocyte cell adhesion complexes (By similarity). Regulates cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation (By similarity). May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1 (PubMed:14966289). Involved in estrogen hormone signaling. {ECO:0000250|UniProtKB:Q9JJ28, ECO:0000269|PubMed:14966289}.
Q13112 CHAF1B T432 ochoa Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-I p60) (M-phase phosphoprotein 7) Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. {ECO:0000269|PubMed:9813080}.
Q13428 TCOF1 T1260 ochoa Treacle protein (Treacher Collins syndrome protein) Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}.
Q14135 VGLL4 T203 ochoa Transcription cofactor vestigial-like protein 4 (Vgl-4) May act as a specific coactivator for the mammalian TEFs. {ECO:0000250}.
Q14511 NEDD9 T185 ochoa Enhancer of filamentation 1 (hEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (Cas scaffolding protein family member 2) (CASS2) (Neural precursor cell expressed developmentally down-regulated protein 9) (NEDD-9) (Renal carcinoma antigen NY-REN-12) (p105) [Cleaved into: Enhancer of filamentation 1 p55] Scaffolding protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion (PubMed:24574519). As a focal adhesion protein, plays a role in embryonic fibroblast migration (By similarity). May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRKL and SHPTP2 to the tyrosine phosphorylated form (PubMed:9020138). Promotes adhesion and migration of lymphocytes; as a result required for the correct migration of lymphocytes to the spleen and other secondary lymphoid organs (PubMed:17174122). Plays a role in the organization of T-cell F-actin cortical cytoskeleton and the centralization of T-cell receptor microclusters at the immunological synapse (By similarity). Negatively regulates cilia outgrowth in polarized cysts (By similarity). Modulates cilia disassembly via activation of AURKA-mediated phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723). Positively regulates RANKL-induced osteoclastogenesis (By similarity). Required for the maintenance of hippocampal dendritic spines in the dentate gyrus and CA1 regions, thereby involved in spatial learning and memory (By similarity). {ECO:0000250|UniProtKB:A0A8I3PDQ1, ECO:0000250|UniProtKB:O35177, ECO:0000269|PubMed:17174122, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:24574519, ECO:0000269|PubMed:9020138}.
Q14653 IRF3 T253 psp Interferon regulatory factor 3 (IRF-3) Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:22394562, PubMed:24049179, PubMed:25636800, PubMed:27302953, PubMed:31340999, PubMed:36603579, PubMed:8524823). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:11846977, PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:32972995, PubMed:36603579, PubMed:8524823). Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction (PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:36603579). Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases (PubMed:22394562, PubMed:25636800, PubMed:27302953, PubMed:36603579). This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes (PubMed:16154084, PubMed:27302953, PubMed:33440148, PubMed:36603579). Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages (PubMed:16846591). In response to Sendai virus infection, is recruited by TOMM70:HSP90AA1 to mitochondrion and forms an apoptosis complex TOMM70:HSP90AA1:IRF3:BAX inducing apoptosis (PubMed:25609812). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:16154084, ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:24049179, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:31340999, ECO:0000269|PubMed:31413131, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:33440148, ECO:0000269|PubMed:36603579, ECO:0000269|PubMed:8524823, ECO:0000303|PubMed:11846977, ECO:0000303|PubMed:16846591, ECO:0000303|PubMed:16979567, ECO:0000303|PubMed:20049431}.
Q14847 LASP1 T166 ochoa LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50) Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). {ECO:0000250}.
Q15691 MAPRE1 T154 ochoa|psp Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) (EB1) Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:23001180, PubMed:28726242, PubMed:28814570, PubMed:34608293). Recruits other +TIP proteins to microtubules by binding to a conserved Ser-X-Leu-Pro (SXLP) motif in their polypeptide chains (PubMed:19632184, PubMed:36592928). Promotes cytoplasmic microtubule nucleation and elongation (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:28726242, PubMed:28814570). Involved in mitotic spindle positioning by stabilizing microtubules and promoting dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation (PubMed:12388762, PubMed:34608293). Assists chromosome alignment in metaphase by recruiting the SKA complex to the spindle and stabilizing its interactions with microtubule bundles (K-fibers) (PubMed:27225956, PubMed:36592928). Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). Acts as a regulator of autophagosome transport via interaction with CAMSAP2 (PubMed:28726242). Functions downstream of Rho GTPases and DIAPH1 in stable microtubule formation (By similarity). May play a role in cell migration (By similarity). {ECO:0000250|UniProtKB:Q61166, ECO:0000269|PubMed:12388762, ECO:0000269|PubMed:16109370, ECO:0000269|PubMed:19632184, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23001180, ECO:0000269|PubMed:27225956, ECO:0000269|PubMed:28726242, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:34608293, ECO:0000269|PubMed:36592928}.
Q15776 ZKSCAN8 T166 ochoa Zinc finger protein with KRAB and SCAN domains 8 (LD5-1) (Zinc finger protein 192) May be involved in transcriptional regulation.
Q16799 RTN1 T338 ochoa Reticulon-1 (Neuroendocrine-specific protein) Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity. {ECO:0000269|PubMed:15286784}.
Q2KHM9 KIAA0753 T193 ochoa Protein moonraker (MNR) (OFD1- and FOPNL-interacting protein) Involved in centriole duplication (PubMed:24613305, PubMed:26297806). Positively regulates CEP63 centrosomal localization (PubMed:24613305, PubMed:26297806). Required for WDR62 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:24613305, PubMed:26297806). May play a role in cilium assembly. {ECO:0000269|PubMed:24613305, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:28220259}.
Q3KR16 PLEKHG6 T540 ochoa Pleckstrin homology domain-containing family G member 6 (PH domain-containing family G member 6) (Myosin-interacting guanine nucleotide exchange factor) (MyoGEF) Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis. {ECO:0000269|PubMed:16721066, ECO:0000269|PubMed:17881735}.
Q4VCS5 AMOT T717 ochoa Angiomotin Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Repressor of YAP1 and WWTR1/TAZ transcription of target genes, potentially via regulation of Hippo signaling-mediated phosphorylation of YAP1 which results in its recruitment to tight junctions (PubMed:21205866). {ECO:0000269|PubMed:11257124, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:21205866}.
Q53H80 AKIRIN2 T128 ochoa Akirin-2 Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is involved in embryonic development, immunity, myogenesis and brain development (PubMed:34711951). Plays a key role in nuclear protein degradation by promoting import of proteasomes into the nucleus: directly binds to fully assembled 20S proteasomes at one end and to nuclear import receptor IPO9 at the other end, bridging them together and mediating the import of pre-assembled proteasome complexes through the nuclear pore (PubMed:34711951). Involved in innate immunity by regulating the production of interleukin-6 (IL6) downstream of Toll-like receptor (TLR): acts by bridging the NF-kappa-B inhibitor NFKBIZ and the SWI/SNF complex, leading to promote induction of IL6 (By similarity). Also involved in adaptive immunity by promoting B-cell activation (By similarity). Involved in brain development: required for the survival and proliferation of cerebral cortical progenitor cells (By similarity). Involved in myogenesis: required for skeletal muscle formation and skeletal development, possibly by regulating expression of muscle differentiation factors (By similarity). Also plays a role in facilitating interdigital tissue regression during limb development (By similarity). {ECO:0000250|UniProtKB:B1AXD8, ECO:0000269|PubMed:34711951}.
Q5H9R7 PPP6R3 T669 ochoa Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) (Sporulation-induced transcript 4-associated protein SAPL) Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance. {ECO:0000269|PubMed:11401438, ECO:0000269|PubMed:16769727}.
Q5JSP0 FGD3 T139 ochoa FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5) Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}.
Q5SRE5 NUP188 T1712 ochoa Nucleoporin NUP188 (hNup188) Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope (Probable). Required for proper protein transport into the nucleus (PubMed:32275884). {ECO:0000269|PubMed:32275884, ECO:0000305|PubMed:32275884}.
Q5UIP0 RIF1 T986 ochoa Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}.
Q5VZL5 ZMYM4 T220 ochoa Zinc finger MYM-type protein 4 (Zinc finger protein 262) Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}.
Q641Q2 WASHC2A T707 ochoa WASH complex subunit 2A Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}.
Q68CZ2 TNS3 T1296 ochoa Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}.
Q6IAA8 LAMTOR1 T30 ochoa Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1) (Lipid raft adaptor protein p18) (Protein associated with DRMs and endosomes) (p27Kip1-releasing factor from RhoA) (p27RF-Rho) Key component of the Ragulator complex, a multiprotein complex involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:20381137, PubMed:22980980, PubMed:29158492). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (PubMed:22980980, PubMed:28935770, PubMed:29158492, PubMed:30181260, PubMed:31001086, PubMed:32686708, PubMed:36476874). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (PubMed:20381137, PubMed:22980980, PubMed:29158492). LAMTOR1 is directly responsible for anchoring the Ragulator complex to the lysosomal membrane (PubMed:31001086, PubMed:32686708). LAMTOR1 wraps around the other subunits of the Ragulator complex to hold them in place and interacts with the Rag GTPases, thereby playing a key role in the recruitment of the mTORC1 complex to lysosomes (PubMed:28935770, PubMed:29107538, PubMed:29123114, PubMed:29285400). Also involved in the control of embryonic stem cells differentiation via non-canonical RagC/RRAGC and RagD/RRAGD activation: together with FLCN, it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity). Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes (PubMed:20381137, PubMed:22980980). May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes (PubMed:20544018). May also play a role in RHOA activation (PubMed:19654316). {ECO:0000250|UniProtKB:Q9CQ22, ECO:0000269|PubMed:19654316, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:20544018, ECO:0000269|PubMed:22980980, ECO:0000269|PubMed:28935770, ECO:0000269|PubMed:29107538, ECO:0000269|PubMed:29123114, ECO:0000269|PubMed:29158492, ECO:0000269|PubMed:29285400, ECO:0000269|PubMed:30181260, ECO:0000269|PubMed:31001086, ECO:0000269|PubMed:32686708, ECO:0000269|PubMed:36476874}.
Q6JBY9 RCSD1 T287 ochoa CapZ-interacting protein (Protein kinase substrate CapZIP) (RCSD domain-containing protein 1) Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly. {ECO:0000269|PubMed:15850461}.
Q6NYC8 PPP1R18 T493 ochoa Phostensin (Protein phosphatase 1 F-actin cytoskeleton-targeting subunit) (Protein phosphatase 1 regulatory subunit 18) [Isoform 1]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:24434620}.; FUNCTION: [Isoform 4]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:17374523}.
Q6P4F7 ARHGAP11A T562 ochoa Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A) GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000269|PubMed:27957544}.
Q6P4R8 NFRKB T899 ochoa Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B) (INO80 complex subunit G) Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. {ECO:0000269|PubMed:18922472}.; FUNCTION: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex. {ECO:0000269|PubMed:18922472}.
Q6P5Z2 PKN3 T869 ochoa Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN-beta) (Protein-kinase C-related kinase 3) Contributes to invasiveness in malignant prostate cancer. {ECO:0000269|PubMed:15282551}.
Q6PEY2 TUBA3E T51 ochoa Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q6PJG6 BRAT1 T745 ochoa Integrator complex assembly factor BRAT1 (BRCA1-associated ATM activator 1) (BRCA1-associated protein required for ATM activation protein 1) Component of a multiprotein complex required for the assembly of the RNA endonuclease module of the integrator complex (PubMed:39032489, PubMed:39032490). Associates with INTS9 and INTS11 in the cytoplasm and blocks the active site of INTS11 to inhibit the endonuclease activity of INTS11 before formation of the full integrator complex (PubMed:39032489, PubMed:39032490). Following dissociation of WDR73 of the complex, BRAT1 facilitates the nuclear import of the INTS9-INTS11 heterodimer (PubMed:39032489). In the nucleus, INTS4 is integrated to the INTS9-INTS11 heterodimer and BRAT1 is released from the mature RNA endonuclease module by inositol hexakisphosphate (InsP6) (PubMed:39032489). BRAT1 is also involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress (PubMed:16452482, PubMed:22977523). Plays a role in regulating mitochondrial function and cell proliferation (PubMed:25070371). Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors (PubMed:25657994). {ECO:0000269|PubMed:16452482, ECO:0000269|PubMed:22977523, ECO:0000269|PubMed:25070371, ECO:0000269|PubMed:25657994, ECO:0000269|PubMed:39032489, ECO:0000269|PubMed:39032490}.
Q6ZRV2 FAM83H T414 ochoa Protein FAM83H May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}.
Q71F23 CENPU T110 ochoa Centromere protein U (CENP-U) (Centromere protein of 50 kDa) (CENP-50) (Interphase centromere complex protein 24) (KSHV latent nuclear antigen-interacting protein 1) (MLF1-interacting protein) (Polo-box-interacting protein 1) Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. {ECO:0000269|PubMed:12941884, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:17081991}.
Q71U36 TUBA1A T51 ochoa Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q71U36 TUBA1A T94 ochoa Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q7KZF4 SND1 T429 ochoa|psp Staphylococcal nuclease domain-containing protein 1 (EC 3.1.31.1) (100 kDa coactivator) (EBNA2 coactivator p100) (Tudor domain-containing protein 11) (p100 co-activator) Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (PubMed:18453631, PubMed:28546213). As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (PubMed:28546213). Functions as a bridging factor between STAT6 and the basal transcription factor (PubMed:12234934). Plays a role in PIM1 regulation of MYB activity (PubMed:9809063). Functions as a transcriptional coactivator for STAT5 (By similarity). {ECO:0000250|UniProtKB:Q78PY7, ECO:0000269|PubMed:12234934, ECO:0000269|PubMed:18453631, ECO:0000269|PubMed:28546213, ECO:0000269|PubMed:9809063}.; FUNCTION: (Microbial infection) Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2). {ECO:0000269|PubMed:7651391}.; FUNCTION: (Microbial infection) Promotes SARS-CoV-2 RNA synthesis by binding to negative-sense RNA and the viral protein nsp9. {ECO:0000269|PubMed:37794589}.
Q7L2J0 MEPCE T243 ochoa 7SK snRNA methylphosphate capping enzyme (MePCE) (EC 2.1.1.-) (Bicoid-interacting protein 3 homolog) (Bin3 homolog) S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723, PubMed:38100593). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723). Also required for stability of U6 snRNAs (PubMed:38100593). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:19906723, ECO:0000269|PubMed:28254838, ECO:0000269|PubMed:30559425, ECO:0000269|PubMed:38100593}.
Q7Z2K8 GPRIN1 T392 ochoa G protein-regulated inducer of neurite outgrowth 1 (GRIN1) May be involved in neurite outgrowth. {ECO:0000250}.
Q7Z2Z1 TICRR T1677 ochoa Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}.
Q7Z591 AKNA T938 ochoa Microtubule organization protein AKNA (AT-hook-containing transcription factor) Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}.
Q7Z5L9 IRF2BP2 T412 ochoa Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2) Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed:12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed:21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed:20702774). Plays a role in immature B-cell differentiation (PubMed:27016798). {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:20702774, ECO:0000269|PubMed:21576369, ECO:0000269|PubMed:27016798}.
Q7Z6Z7 HUWE1 T2746 ochoa E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}.
Q86UP2 KTN1 T1316 ochoa Kinectin (CG-1 antigen) (Kinesin receptor) Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin.
Q86XP3 DDX42 T757 ochoa ATP-dependent RNA helicase DDX42 (EC 3.6.4.13) (DEAD box protein 42) (RNA helicase-like protein) (RHELP) (RNA helicase-related protein) (RNAHP) (SF3b DEAD box protein) (Splicing factor 3B-associated 125 kDa protein) (SF3b125) ATP-dependent RNA helicase that binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures (PubMed:16397294). Unwinding is promoted in the presence of single-strand binding proteins (PubMed:16397294). Also mediates RNA duplex formation thereby displacing the single-strand RNA binding protein (PubMed:16397294). ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands (PubMed:16397294). Required for assembly of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs: DDX42 associates transiently with the SF3B subcomplex of the 17S U2 SnRNP complex and is released after fulfilling its role in the assembly of 17S U2 SnRNP (PubMed:12234937, PubMed:36797247). Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2 (PubMed:19377511). Relocalizes TP53BP2 to the cytoplasm (PubMed:19377511). {ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:16397294, ECO:0000269|PubMed:19377511, ECO:0000269|PubMed:36797247}.
Q8IVH2 FOXP4 T276 ochoa Forkhead box protein P4 (Fork head-related protein-like A) Transcriptional repressor that represses lung-specific expression. {ECO:0000250}.
Q8IWB9 TEX2 T269 ochoa Testis-expressed protein 2 (Transmembrane protein 96) During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation. {ECO:0000269|PubMed:28011845}.
Q8IXJ9 ASXL1 T469 ochoa Polycomb group protein ASXL1 (Additional sex combs-like protein 1) Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG) (PubMed:16606617). Acts as a coactivator of RARA and RXRA through association with NCOA1 (PubMed:16606617). Acts as a corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity (By similarity). Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:20436459, PubMed:30664650, PubMed:36180891). Acts as a sensor of N(6)-methyladenine methylation on DNA (6mA): recognizes and binds 6mA DNA, leading to its ubiquitination and degradation by TRIP12, thereby inactivating the PR-DUB complex and regulating Polycomb silencing (PubMed:30982744). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:30664650, PubMed:36180891). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity) (PubMed:30664650). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes (By similarity). ASXL1 and ASXL2 are important for BAP1 protein stability (PubMed:30664650). Together with BAP1, negatively regulates epithelial-mesenchymal transition (EMT) of trophoblast stem cells during placental development by regulating genes involved in epithelial cell integrity, cell adhesion and cytoskeletal organization (PubMed:34170818). {ECO:0000250|UniProtKB:P59598, ECO:0000269|PubMed:16606617, ECO:0000269|PubMed:20436459, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:30982744, ECO:0000269|PubMed:34170818, ECO:0000269|PubMed:36180891}.
Q8N302 AGGF1 T341 ochoa Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (hVG5Q) (G patch domain-containing protein 7) (Vasculogenesis gene on 5q protein) Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. {ECO:0000269|PubMed:14961121}.
Q8N5F7 NKAP T298 ochoa NF-kappa-B-activating protein Acts as a transcriptional repressor (PubMed:14550261, PubMed:19409814, PubMed:31587868). Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development (PubMed:19409814). Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter. {ECO:0000269|PubMed:14550261, ECO:0000269|PubMed:19409814, ECO:0000269|PubMed:31587868}.
Q8N8Z6 DCBLD1 T692 ochoa Discoidin, CUB and LCCL domain-containing protein 1 None
Q8TD55 PLEKHO2 T442 ochoa Pleckstrin homology domain-containing family O member 2 (PH domain-containing family O member 2) (Pleckstrin homology domain-containing family Q member 1) (PH domain-containing family Q member 1) None
Q8TDY4 ASAP3 T732 ochoa Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 (Development and differentiation-enhancing factor-like 1) (Protein up-regulated in liver cancer 1) Promotes cell proliferation. {ECO:0000269|PubMed:14654939}.
Q8TEW8 PARD3B T341 ochoa Partitioning defective 3 homolog B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein) (PAR3-beta) (Partitioning defective 3-like protein) (PAR3-L protein) Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions.
Q8WUY3 PRUNE2 T1792 ochoa Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}.
Q8WXI9 GATAD2B T489 ochoa Transcriptional repressor p66-beta (GATA zinc finger domain-containing protein 2B) (p66/p68) Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2A (PubMed:16415179). Targets MBD3 to discrete loci in the nucleus (PubMed:11756549). May play a role in synapse development (PubMed:23644463). {ECO:0000269|PubMed:11756549, ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:23644463, ECO:0000269|PubMed:28977666}.
Q92797 SYMPK T1246 ochoa Symplekin Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity. {ECO:0000269|PubMed:16230528, ECO:0000269|PubMed:20861839}.
Q92844 TANK T260 ochoa TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF) Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. {ECO:0000269|PubMed:12133833, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:25861989}.
Q92934 BAD T137 psp Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death) Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. {ECO:0000250}.
Q93009 USP7 T966 ochoa Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12) (Deubiquitinating enzyme 7) (Herpesvirus-associated ubiquitin-specific protease) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7) Hydrolase that deubiquitinates target proteins such as ARMC5, FOXO4, DEPTOR, KAT5, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5 and DAXX (PubMed:11923872, PubMed:15053880, PubMed:16964248, PubMed:18716620, PubMed:25283148, PubMed:25865756, PubMed:26678539, PubMed:28655758, PubMed:33544460, PubMed:35216969). Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation (PubMed:15053880, PubMed:16845383, PubMed:18566590, PubMed:20153724). Deubiquitinates p53/TP53, preventing degradation of p53/TP53, and enhances p53/TP53-dependent transcription regulation, cell growth repression and apoptosis (PubMed:25283148). Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis (PubMed:11923872, PubMed:26786098). Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity (PubMed:16964248). In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML (PubMed:18716620). Deubiquitinates KMT2E/MLL5 preventing KMT2E/MLL5 proteasomal-mediated degradation (PubMed:26678539). Involved in cell proliferation during early embryonic development. Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6 (PubMed:22466611, PubMed:22466612). Involved in maintenance of DNA methylation via its interaction with UHRF1 and DNMT1: acts by mediating deubiquitination of UHRF1 and DNMT1, preventing their degradation and promoting DNA methylation by DNMT1 (PubMed:21745816, PubMed:22411829). Deubiquitinates alkylation repair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex (PubMed:20601937). Able to mediate deubiquitination of histone H2B; it is however unsure whether this activity takes place in vivo (PubMed:20601937). Exhibits a preference towards 'Lys-48'-linked ubiquitin chains (PubMed:22689415). Increases regulatory T-cells (Treg) suppressive capacity by deubiquitinating and stabilizing the transcription factor FOXP3 which is crucial for Treg cell function (PubMed:23973222). Plays a role in the maintenance of the circadian clock periodicity via deubiquitination and stabilization of the CRY1 and CRY2 proteins (PubMed:27123980). Deubiquitinates REST, thereby stabilizing REST and promoting the maintenance of neural progenitor cells (PubMed:21258371). Deubiquitinates SIRT7, inhibiting SIRT7 histone deacetylase activity and regulating gluconeogenesis (PubMed:28655758). Involved in the regulation of WASH-dependent actin polymerization at the surface of endosomes and the regulation of endosomal protein recycling (PubMed:26365382). It maintains optimal WASH complex activity and precise F-actin levels via deubiquitination of TRIM27 and WASHC1 (PubMed:26365382). Mediates the deubiquitination of phosphorylated DEPTOR, promoting its stability and leading to decreased mTORC1 signaling (PubMed:35216969). {ECO:0000269|PubMed:11923872, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:16845383, ECO:0000269|PubMed:16964248, ECO:0000269|PubMed:18566590, ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:20153724, ECO:0000269|PubMed:20601937, ECO:0000269|PubMed:21258371, ECO:0000269|PubMed:21745816, ECO:0000269|PubMed:22411829, ECO:0000269|PubMed:22466611, ECO:0000269|PubMed:22466612, ECO:0000269|PubMed:22689415, ECO:0000269|PubMed:23973222, ECO:0000269|PubMed:25283148, ECO:0000269|PubMed:25865756, ECO:0000269|PubMed:25944111, ECO:0000269|PubMed:26365382, ECO:0000269|PubMed:26678539, ECO:0000269|PubMed:26786098, ECO:0000269|PubMed:27123980, ECO:0000269|PubMed:28655758, ECO:0000269|PubMed:33544460, ECO:0000269|PubMed:35216969}.; FUNCTION: (Microbial infection) Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection. {ECO:0000269|PubMed:14506283, ECO:0000269|PubMed:16160161, ECO:0000269|PubMed:18590780}.; FUNCTION: (Microbial infection) Upon infection with Epstein-Barr virus, the interaction with viral EBNA1 increases the association of USP7 with PML proteins, which is required for the polyubiquitylation and degradation of PML. {ECO:0000269|PubMed:20719947, ECO:0000269|PubMed:24216761}.
Q96C57 CUSTOS T182 ochoa Protein CUSTOS Plays a role in the regulation of Wnt signaling pathway during early development. {ECO:0000250|UniProtKB:A9C3N6}.
Q96II8 LRCH3 Y595 ochoa DISP complex protein LRCH3 (Leucine-rich repeat and calponin homology domain-containing protein 3) As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. {ECO:0000269|PubMed:29467281}.
Q96M96 FGD4 T144 ochoa FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament-binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6) Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity). {ECO:0000250, ECO:0000269|PubMed:15133042}.
Q96NU1 SAMD11 T643 ochoa Sterile alpha motif domain-containing protein 11 (SAM domain-containing protein 11) Component of a Polycomb group (PcG) multiprotein PRC1-like complex, essential for establishing rod photoreceptor cell identity and function by silencing nonrod gene expression in developing rod photoreceptor cells. {ECO:0000250|UniProtKB:Q1RNF8}.
Q96PE2 ARHGEF17 T530 ochoa Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}.
Q9BQE3 TUBA1C T51 ochoa Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q9BQE3 TUBA1C T94 ochoa Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q9BW04 SARG T465 ochoa Specifically androgen-regulated gene protein Putative androgen-specific receptor. {ECO:0000269|PubMed:15525603}.
Q9BXK5 BCL2L13 T374 ochoa Bcl-2-like protein 13 (Bcl2-L-13) (Bcl-rambo) (Protein Mil1) May promote the activation of caspase-3 and apoptosis.
Q9BXS5 AP1M1 T152 ochoa AP-1 complex subunit mu-1 (AP-mu chain family member mu1A) (Adaptor protein complex AP-1 subunit mu-1) (Adaptor-related protein complex 1 subunit mu-1) (Clathrin assembly protein complex 1 mu-1 medium chain 1) (Clathrin coat assembly protein AP47) (Clathrin coat-associated protein AP47) (Golgi adaptor HA1/AP1 adaptin mu-1 subunit) (Mu-adaptin 1) (Mu1A-adaptin) Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
Q9C0C2 TNKS1BP1 T501 ochoa 182 kDa tankyrase-1-binding protein None
Q9C0D5 TANC1 T347 ochoa Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) May be a scaffold component in the postsynaptic density. {ECO:0000250}.
Q9H3D4 TP63 T625 ochoa Tumor protein 63 (p63) (Chronic ulcerative stomatitis protein) (CUSP) (Keratinocyte transcription factor KET) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) (p40) (p51) Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter. {ECO:0000269|PubMed:11641404, ECO:0000269|PubMed:12374749, ECO:0000269|PubMed:12446779, ECO:0000269|PubMed:12446784, ECO:0000269|PubMed:20123734, ECO:0000269|PubMed:22197488, ECO:0000269|PubMed:9774969}.
Q9H792 PEAK1 T822 ochoa Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}.
Q9H8K7 PAAT T427 ochoa ATPase PAAT (EC 3.6.1.-) (Protein associated with ABC transporters) (PAAT) ATPase that regulates mitochondrial ABC transporters ABCB7, ABCB8/MITOSUR and ABCB10 (PubMed:25063848). Regulates mitochondrial ferric concentration and heme biosynthesis and plays a role in the maintenance of mitochondrial homeostasis and cell survival (PubMed:25063848). {ECO:0000269|PubMed:25063848}.
Q9HCE1 MOV10 T972 ochoa Helicase MOV-10 (EC 3.6.4.13) (Armitage homolog) (Moloney leukemia virus 10 protein) 5' to 3' RNA helicase that is involved in a number of cellular roles ranging from mRNA metabolism and translation, modulation of viral infectivity, inhibition of retrotransposition, or regulation of synaptic transmission (PubMed:23093941). Plays an important role in innate antiviral immunity by promoting type I interferon production (PubMed:27016603, PubMed:27974568, PubMed:35157734). Mechanistically, specifically uses IKKepsilon/IKBKE as the mediator kinase for IRF3 activation (PubMed:27016603, PubMed:35157734). Blocks HIV-1 virus replication at a post-entry step (PubMed:20215113). Counteracts HIV-1 Vif-mediated degradation of APOBEC3G through its helicase activity by interfering with the ubiquitin-proteasome pathway (PubMed:29258557). Also inhibits hepatitis B virus/HBV replication by interacting with HBV RNA and thereby inhibiting the early step of viral reverse transcription (PubMed:31722967). Contributes to UPF1 mRNA target degradation by translocation along 3' UTRs (PubMed:24726324). Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:16289642, PubMed:17507929, PubMed:22791714). In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 (PubMed:25464849). Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1 (PubMed:23093941, PubMed:30122351). Facilitates LINE-1 uridylation by TUT4 and TUT7 (PubMed:30122351). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (By similarity). May function as a messenger ribonucleoprotein (mRNP) clearance factor (PubMed:24726324). {ECO:0000250|UniProtKB:P23249, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:20215113, ECO:0000269|PubMed:22791714, ECO:0000269|PubMed:23093941, ECO:0000269|PubMed:24726324, ECO:0000269|PubMed:25464849, ECO:0000269|PubMed:27016603, ECO:0000269|PubMed:27974568, ECO:0000269|PubMed:29258557, ECO:0000269|PubMed:30122351, ECO:0000269|PubMed:31722967, ECO:0000269|PubMed:35157734}.; FUNCTION: (Microbial infection) Required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription. {ECO:0000269|PubMed:18552826}.
Q9NP66 HMG20A T108 ochoa High mobility group protein 20A (HMG box-containing protein 20A) (HMG domain-containing protein 1) (HMG domain-containing protein HMGX1) Plays a role in neuronal differentiation as chromatin-associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4 (By similarity). {ECO:0000250}.
Q9NTJ3 SMC4 T44 ochoa Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (hCAP-C) (XCAP-C homolog) Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}.
Q9NY65 TUBA8 T94 ochoa Tubulin alpha-8 chain (EC 3.6.5.-) (Alpha-tubulin 8) (Tubulin alpha chain-like 2) [Cleaved into: Dephenylalaninated tubulin alpha-8 chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q9NYD6 HOXC10 T244 ochoa Homeobox protein Hox-C10 (Homeobox protein Hox-3I) Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Q9P206 NHSL3 T932 ochoa NHS-like protein 3 Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}.
Q9UBP9 GULP1 T214 ochoa PTB domain-containing engulfment adapter protein 1 (Cell death protein 6 homolog) (PTB domain adapter protein CED-6) (Protein GULP) May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6. {ECO:0000269|PubMed:10574763, ECO:0000269|PubMed:10574771, ECO:0000269|PubMed:16497666, ECO:0000269|PubMed:17398097}.
Q9UK61 TASOR T982 ochoa Protein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein) Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity). {ECO:0000250|UniProtKB:Q69ZR9, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}.
Q9UKA4 AKAP11 T1583 ochoa A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11) Binds to type II regulatory subunits of protein kinase A and anchors/targets them.
Q9UKS6 PACSIN3 T347 ochoa Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11082044}.
Q9UKS7 IKZF2 T372 ochoa Zinc finger protein Helios (Ikaros family zinc finger protein 2) Transcriptional regulator required for outer hair cells (OHC) maturation and, consequently, for hearing. {ECO:0000250|UniProtKB:P81183}.
Q9ULR3 PPM1H T224 ochoa Protein phosphatase 1H (EC 3.1.3.16) Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation. {ECO:0000269|PubMed:22586611}.
Q9UN81 L1RE1 T30 ochoa LINE-1 retrotransposable element ORF1 protein (L1ORF1p) (LINE retrotransposable element 1) (LINE1 retrotransposable element 1) Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded. {ECO:0000269|PubMed:11158327, ECO:0000269|PubMed:21937507, ECO:0000269|PubMed:28806172, ECO:0000269|PubMed:30122351, ECO:0000269|PubMed:8945518}.
Q9UPN4 CEP131 T117 ochoa Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}.
Q9UQP3 TNN T941 ochoa Tenascin-N (TN-N) (Tenascin-W) (TN-W) Extracellular matrix protein that seems to be a ligand for ITGA8:ITGB1, ITGAV:ITGB1 and ITGA4:ITGB1 (By similarity) (PubMed:17909022). Involved in neurite outgrowth and cell migration in hippocampal explants (By similarity). During endochondral bone formation, inhibits proliferation and differentiation of proteoblasts mediated by canonical WNT signaling (By similarity). In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). Expressed in most mammary tumors, may facilitate tumorigenesis by supporting the migratory behavior of breast cancer cells (PubMed:17909022). {ECO:0000250|UniProtKB:Q80YX1, ECO:0000250|UniProtKB:Q80Z71, ECO:0000269|PubMed:17909022, ECO:0000269|PubMed:19884327}.
Q9Y2X9 ZNF281 T654 ochoa Zinc finger protein 281 (GC-box-binding zinc finger protein 1) (Transcription factor ZBP-99) (Zinc finger DNA-binding protein 99) Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes. {ECO:0000250, ECO:0000269|PubMed:10448078, ECO:0000269|PubMed:12771217}.
Q9Y4A5 TRRAP T1631 ochoa Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog) Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. May play a role in the formation and maintenance of the auditory system (By similarity). {ECO:0000250|UniProtKB:A0A0R4ITC5, ECO:0000269|PubMed:11418595, ECO:0000269|PubMed:12138177, ECO:0000269|PubMed:12660246, ECO:0000269|PubMed:12743606, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:17967892, ECO:0000269|PubMed:24463511, ECO:0000269|PubMed:9708738}.
Q9Y613 FHOD1 T489 ochoa FH1/FH2 domain-containing protein 1 (Formin homolog overexpressed in spleen 1) (FHOS) (Formin homology 2 domain-containing protein 1) Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing. {ECO:0000269|PubMed:14576350, ECO:0000269|PubMed:15878344, ECO:0000269|PubMed:18694941}.
Q9Y6A5 TACC3 T437 ochoa Transforming acidic coiled-coil-containing protein 3 (ERIC-1) Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). {ECO:0000250|UniProtKB:Q9JJ11, ECO:0000269|PubMed:14767476, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}.
P08865 RPSA T82 Sugiyama Small ribosomal subunit protein uS2 (37 kDa laminin receptor precursor) (37LRP) (37/67 kDa laminin receptor) (LRP/LR) (40S ribosomal protein SA) (67 kDa laminin receptor) (67LR) (Colon carcinoma laminin-binding protein) (Laminin receptor 1) (LamR) (Laminin-binding protein precursor p40) (LBP/p40) (Multidrug resistance-associated protein MGr1-Ag) (NEM/1CHD4) Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. {ECO:0000255|HAMAP-Rule:MF_03016, ECO:0000269|PubMed:16263087, ECO:0000269|PubMed:6300843}.; FUNCTION: (Microbial infection) Acts as a receptor for the Adeno-associated viruses 2,3,8 and 9. {ECO:0000269|PubMed:16973587}.; FUNCTION: (Microbial infection) Acts as a receptor for the Dengue virus. {ECO:0000269|PubMed:15507651}.; FUNCTION: (Microbial infection) Acts as a receptor for the Sindbis virus. {ECO:0000269|PubMed:1385835}.; FUNCTION: (Microbial infection) Acts as a receptor for the Venezuelan equine encephalitis virus. {ECO:0000269|PubMed:1385835}.; FUNCTION: (Microbial infection) Acts as a receptor for the pathogenic prion protein. {ECO:0000269|PubMed:11689427, ECO:0000269|PubMed:9396609}.; FUNCTION: (Microbial infection) Acts as a receptor for bacteria. {ECO:0000269|PubMed:15516338}.
P30101 PDIA3 T120 Sugiyama Protein disulfide-isomerase A3 (EC 5.3.4.1) (58 kDa glucose-regulated protein) (58 kDa microsomal protein) (p58) (Disulfide isomerase ER-60) (Endoplasmic reticulum resident protein 57) (ER protein 57) (ERp57) (Endoplasmic reticulum resident protein 60) (ER protein 60) (ERp60) Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone (PubMed:11825568, PubMed:16193070, PubMed:27897272, PubMed:36104323, PubMed:7487104). Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity (PubMed:35948544, PubMed:36104323). {ECO:0000269|PubMed:11825568, ECO:0000269|PubMed:16193070, ECO:0000269|PubMed:27897272, ECO:0000269|PubMed:35948544, ECO:0000269|PubMed:36104323, ECO:0000269|PubMed:7487104}.
P62829 RPL23 T118 Sugiyama Large ribosomal subunit protein uL14 (60S ribosomal protein L17) (60S ribosomal protein L23) Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}.
P51813 BMX T190 Sugiyama Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Also plays a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells. {ECO:0000269|PubMed:10688651, ECO:0000269|PubMed:11331870, ECO:0000269|PubMed:12370298, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:15788485, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:9520419}.
P12956 XRCC6 T541 Sugiyama X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6) Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Negatively regulates apoptosis by interacting with BAX and sequestering it from the mitochondria (PubMed:15023334). Might have deubiquitination activity, acting on BAX (PubMed:18362350). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:15023334, ECO:0000269|PubMed:18362350, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:20493174, ECO:0000269|PubMed:2466842, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488, ECO:0000269|PubMed:9742108}.
P14598 NCF1 T133 SIGNOR|EPSD|PSP Neutrophil cytosol factor 1 (NCF-1) (47 kDa autosomal chronic granulomatous disease protein) (47 kDa neutrophil oxidase factor) (NCF-47K) (Neutrophil NADPH oxidase factor 1) (Nox organizer 2) (Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A) (p47-phox) Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:2547247, PubMed:2550933, PubMed:38355798). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (PubMed:38355798). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (PubMed:38355798). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (PubMed:12732142, PubMed:19801500). {ECO:0000269|PubMed:12732142, ECO:0000269|PubMed:19801500, ECO:0000269|PubMed:2547247, ECO:0000269|PubMed:2550933, ECO:0000269|PubMed:38355798}.
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reactome_id name p -log10_p
R-HSA-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 8.560064e-11 10.068
R-HSA-190872 Transport of connexons to the plasma membrane 1.211442e-10 9.917
R-HSA-389977 Post-chaperonin tubulin folding pathway 2.321500e-10 9.634
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC 9.575117e-10 9.019
R-HSA-9619483 Activation of AMPK downstream of NMDARs 2.520863e-09 8.598
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 4.836059e-09 8.316
R-HSA-437239 Recycling pathway of L1 5.671535e-09 8.246
R-HSA-9668328 Sealing of the nuclear envelope (NE) by ESCRT-III 7.247179e-09 8.140
R-HSA-190861 Gap junction assembly 1.063403e-08 7.973
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 2.226260e-08 7.652
R-HSA-453274 Mitotic G2-G2/M phases 2.472968e-08 7.607
R-HSA-9646399 Aggrephagy 3.016755e-08 7.520
R-HSA-983189 Kinesins 3.433827e-08 7.464
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 4.383441e-08 7.358
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 4.140990e-08 7.383
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 5.933962e-08 7.227
R-HSA-9663891 Selective autophagy 5.933962e-08 7.227
R-HSA-190828 Gap junction trafficking 6.497275e-08 7.187
R-HSA-1632852 Macroautophagy 7.485960e-08 7.126
R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin 9.926059e-08 7.003
R-HSA-157858 Gap junction trafficking and regulation 1.299140e-07 6.886
R-HSA-9612973 Autophagy 2.081523e-07 6.682
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 2.752525e-07 6.560
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 2.957422e-07 6.529
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 4.425730e-07 6.354
R-HSA-373760 L1CAM interactions 8.409449e-07 6.075
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 1.176128e-06 5.930
R-HSA-69275 G2/M Transition 1.146482e-06 5.941
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 1.108240e-06 5.955
R-HSA-6807878 COPI-mediated anterograde transport 1.465818e-06 5.834
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 1.465818e-06 5.834
R-HSA-5620920 Cargo trafficking to the periciliary membrane 1.473425e-06 5.832
R-HSA-68877 Mitotic Prometaphase 1.617083e-06 5.791
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 1.770042e-06 5.752
R-HSA-9833482 PKR-mediated signaling 3.241487e-06 5.489
R-HSA-390466 Chaperonin-mediated protein folding 6.084755e-06 5.216
R-HSA-438064 Post NMDA receptor activation events 6.084755e-06 5.216
R-HSA-69278 Cell Cycle, Mitotic 6.324396e-06 5.199
R-HSA-199977 ER to Golgi Anterograde Transport 6.803131e-06 5.167
R-HSA-391251 Protein folding 9.403234e-06 5.027
R-HSA-2132295 MHC class II antigen presentation 1.055284e-05 4.977
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 1.195563e-05 4.922
R-HSA-913531 Interferon Signaling 1.329407e-05 4.876
R-HSA-2467813 Separation of Sister Chromatids 1.572975e-05 4.803
R-HSA-8856688 Golgi-to-ER retrograde transport 1.929328e-05 4.715
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 1.947740e-05 4.710
R-HSA-5620924 Intraflagellar transport 2.290293e-05 4.640
R-HSA-68882 Mitotic Anaphase 2.654390e-05 4.576
R-HSA-2555396 Mitotic Metaphase and Anaphase 2.757503e-05 4.559
R-HSA-1640170 Cell Cycle 3.795417e-05 4.421
R-HSA-5617833 Cilium Assembly 5.003744e-05 4.301
R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... 5.231879e-05 4.281
R-HSA-9609690 HCMV Early Events 6.315580e-05 4.200
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 7.344070e-05 4.134
R-HSA-948021 Transport to the Golgi and subsequent modification 7.909569e-05 4.102
R-HSA-5610787 Hedgehog 'off' state 1.323778e-04 3.878
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 1.502913e-04 3.823
R-HSA-68886 M Phase 2.035367e-04 3.691
R-HSA-9609646 HCMV Infection 3.890899e-04 3.410
R-HSA-1538133 G0 and Early G1 5.942394e-04 3.226
R-HSA-5358351 Signaling by Hedgehog 9.571410e-04 3.019
R-HSA-199991 Membrane Trafficking 1.030693e-03 2.987
R-HSA-1169408 ISG15 antiviral mechanism 1.499808e-03 2.824
R-HSA-422475 Axon guidance 1.561950e-03 2.806
R-HSA-5660489 MTF1 activates gene expression 1.677317e-03 2.775
R-HSA-68911 G2 Phase 2.268297e-03 2.644
R-HSA-1852241 Organelle biogenesis and maintenance 2.177217e-03 2.662
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 2.305909e-03 2.637
R-HSA-8949215 Mitochondrial calcium ion transport 2.549678e-03 2.594
R-HSA-9675108 Nervous system development 2.775217e-03 2.557
R-HSA-8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... 3.701503e-03 2.432
R-HSA-193648 NRAGE signals death through JNK 3.925199e-03 2.406
R-HSA-139915 Activation of PUMA and translocation to mitochondria 4.540367e-03 2.343
R-HSA-446203 Asparagine N-linked glycosylation 4.782578e-03 2.320
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 5.639285e-03 2.249
R-HSA-380259 Loss of Nlp from mitotic centrosomes 5.639285e-03 2.249
R-HSA-114452 Activation of BH3-only proteins 5.666357e-03 2.247
R-HSA-8953897 Cellular responses to stimuli 5.595336e-03 2.252
R-HSA-8854518 AURKA Activation by TPX2 6.505746e-03 2.187
R-HSA-112315 Transmission across Chemical Synapses 7.395236e-03 2.131
R-HSA-164843 2-LTR circle formation 7.526350e-03 2.123
R-HSA-5653656 Vesicle-mediated transport 8.247798e-03 2.084
R-HSA-2559585 Oncogene Induced Senescence 8.620760e-03 2.064
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 8.859985e-03 2.053
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 8.859985e-03 2.053
R-HSA-380287 Centrosome maturation 9.622292e-03 2.017
R-HSA-9013973 TICAM1-dependent activation of IRF3/IRF7 9.892265e-03 2.005
R-HSA-162592 Integration of provirus 9.892265e-03 2.005
R-HSA-9661069 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 1.254398e-02 1.902
R-HSA-9659787 Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 1.254398e-02 1.902
R-HSA-198323 AKT phosphorylates targets in the cytosol 1.118315e-02 1.951
R-HSA-162582 Signal Transduction 1.285293e-02 1.891
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 1.357690e-02 1.867
R-HSA-165159 MTOR signalling 1.374020e-02 1.862
R-HSA-2262752 Cellular responses to stress 1.465022e-02 1.834
R-HSA-3270619 IRF3-mediated induction of type I IFN 1.546957e-02 1.811
R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 1.703142e-02 1.769
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 1.727626e-02 1.763
R-HSA-8986944 Transcriptional Regulation by MECP2 1.785109e-02 1.748
R-HSA-936964 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 1.865742e-02 1.729
R-HSA-5660526 Response to metal ions 1.865742e-02 1.729
R-HSA-5688426 Deubiquitination 2.009650e-02 1.697
R-HSA-9827857 Specification of primordial germ cells 2.034618e-02 1.692
R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex 2.577533e-02 1.589
R-HSA-453279 Mitotic G1 phase and G1/S transition 2.407424e-02 1.618
R-HSA-162594 Early Phase of HIV Life Cycle 2.770157e-02 1.557
R-HSA-73887 Death Receptor Signaling 2.872615e-02 1.542
R-HSA-1834941 STING mediated induction of host immune responses 2.390648e-02 1.621
R-HSA-109606 Intrinsic Pathway for Apoptosis 2.609794e-02 1.583
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 2.714846e-02 1.566
R-HSA-193704 p75 NTR receptor-mediated signalling 2.425800e-02 1.615
R-HSA-1280215 Cytokine Signaling in Immune system 2.347999e-02 1.629
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 2.979864e-02 1.526
R-HSA-166208 mTORC1-mediated signalling 3.172103e-02 1.499
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 3.189648e-02 1.496
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 3.381173e-02 1.471
R-HSA-9824446 Viral Infection Pathways 3.514478e-02 1.454
R-HSA-429947 Deadenylation of mRNA 3.595476e-02 1.444
R-HSA-1257604 PIP3 activates AKT signaling 3.778559e-02 1.423
R-HSA-5628897 TP53 Regulates Metabolic Genes 3.891599e-02 1.410
R-HSA-9022699 MECP2 regulates neuronal receptors and channels 4.039294e-02 1.394
R-HSA-597592 Post-translational protein modification 4.171210e-02 1.380
R-HSA-5689880 Ub-specific processing proteases 4.272152e-02 1.369
R-HSA-5205685 PINK1-PRKN Mediated Mitophagy 4.502607e-02 1.347
R-HSA-5626978 TNFR1-mediated ceramide production 5.753327e-02 1.240
R-HSA-165181 Inhibition of TSC complex formation by PKB 5.753327e-02 1.240
R-HSA-9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells 4.741285e-02 1.324
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 6.049509e-02 1.218
R-HSA-72163 mRNA Splicing - Major Pathway 6.118121e-02 1.213
R-HSA-8875513 MET interacts with TNS proteins 4.817811e-02 1.317
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 4.984494e-02 1.302
R-HSA-111448 Activation of NOXA and translocation to mitochondria 5.753327e-02 1.240
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 4.984494e-02 1.302
R-HSA-9022692 Regulation of MECP2 expression and activity 5.740202e-02 1.241
R-HSA-9675126 Diseases of mitotic cell cycle 5.484060e-02 1.261
R-HSA-9759475 Regulation of CDH11 Expression and Function 4.741285e-02 1.324
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 5.740202e-02 1.241
R-HSA-3700989 Transcriptional Regulation by TP53 5.293793e-02 1.276
R-HSA-416482 G alpha (12/13) signalling events 5.427286e-02 1.265
R-HSA-112316 Neuronal System 5.460920e-02 1.263
R-HSA-5205647 Mitophagy 6.264672e-02 1.203
R-HSA-74713 IRS activation 6.679705e-02 1.175
R-HSA-203754 NOSIP mediated eNOS trafficking 6.679705e-02 1.175
R-HSA-1606341 IRF3 mediated activation of type 1 IFN 6.679705e-02 1.175
R-HSA-8939247 RUNX1 regulates transcription of genes involved in interleukin signaling 6.679705e-02 1.175
R-HSA-8939245 RUNX1 regulates transcription of genes involved in BCR signaling 6.679705e-02 1.175
R-HSA-3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 6.679705e-02 1.175
R-HSA-9006925 Intracellular signaling by second messengers 6.893453e-02 1.162
R-HSA-6807070 PTEN Regulation 6.987715e-02 1.156
R-HSA-180910 Vpr-mediated nuclear import of PICs 7.080310e-02 1.150
R-HSA-933541 TRAF6 mediated IRF7 activation 7.080310e-02 1.150
R-HSA-72172 mRNA Splicing 7.240453e-02 1.140
R-HSA-5340588 Signaling by RNF43 mutants 7.597035e-02 1.119
R-HSA-8937144 Aryl hydrocarbon receptor signalling 7.597035e-02 1.119
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 7.642199e-02 1.117
R-HSA-9725554 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin 7.642199e-02 1.117
R-HSA-8953750 Transcriptional Regulation by E2F6 7.642199e-02 1.117
R-HSA-1912408 Pre-NOTCH Transcription and Translation 7.742303e-02 1.111
R-HSA-177539 Autointegration results in viral DNA circles 8.505404e-02 1.070
R-HSA-203641 NOSTRIN mediated eNOS trafficking 9.404898e-02 1.027
R-HSA-9732724 IFNG signaling activates MAPKs 9.404898e-02 1.027
R-HSA-112412 SOS-mediated signalling 9.404898e-02 1.027
R-HSA-9828211 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 1.029560e-01 0.987
R-HSA-9768778 Regulation of NPAS4 mRNA translation 1.029560e-01 0.987
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 7.928294e-02 1.101
R-HSA-72165 mRNA Splicing - Minor Pathway 1.001858e-01 0.999
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 1.064135e-01 0.973
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 7.921932e-02 1.101
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 1.165921e-01 0.933
R-HSA-164940 Nef mediated downregulation of MHC class I complex cell surface expression 1.029560e-01 0.987
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 1.165921e-01 0.933
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 8.217697e-02 1.085
R-HSA-176033 Interactions of Vpr with host cellular proteins 7.928294e-02 1.101
R-HSA-9603381 Activated NTRK3 signals through PI3K 9.404898e-02 1.027
R-HSA-111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 1.029560e-01 0.987
R-HSA-175567 Integration of viral DNA into host genomic DNA 8.505404e-02 1.070
R-HSA-8948747 Regulation of PTEN localization 9.404898e-02 1.027
R-HSA-2559580 Oxidative Stress Induced Senescence 1.021397e-01 0.991
R-HSA-157118 Signaling by NOTCH 1.163553e-01 0.934
R-HSA-109581 Apoptosis 1.039990e-01 0.983
R-HSA-69236 G1 Phase 9.406590e-02 1.027
R-HSA-69231 Cyclin D associated events in G1 9.406590e-02 1.027
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 9.406590e-02 1.027
R-HSA-72187 mRNA 3'-end processing 1.191670e-01 0.924
R-HSA-198203 PI3K/AKT activation 1.205099e-01 0.919
R-HSA-74749 Signal attenuation 1.205099e-01 0.919
R-HSA-1236973 Cross-presentation of particulate exogenous antigens (phagosomes) 1.205099e-01 0.919
R-HSA-2586552 Signaling by Leptin 1.205099e-01 0.919
R-HSA-9762292 Regulation of CDH11 function 1.205099e-01 0.919
R-HSA-9764790 Positive Regulation of CDH1 Gene Transcription 1.205099e-01 0.919
R-HSA-432722 Golgi Associated Vesicle Biogenesis 1.224129e-01 0.912
R-HSA-927802 Nonsense-Mediated Decay (NMD) 1.251766e-01 0.902
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 1.251766e-01 0.902
R-HSA-72649 Translation initiation complex formation 1.256803e-01 0.901
R-HSA-1912422 Pre-NOTCH Expression and Processing 1.273578e-01 0.895
R-HSA-9759811 Regulation of CDH11 mRNA translation by microRNAs 1.291585e-01 0.889
R-HSA-72702 Ribosomal scanning and start codon recognition 1.322768e-01 0.879
R-HSA-2559583 Cellular Senescence 1.354552e-01 0.868
R-HSA-2514853 Condensation of Prometaphase Chromosomes 1.377224e-01 0.861
R-HSA-9824878 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 1.377224e-01 0.861
R-HSA-9820865 Z-decay: degradation of maternal mRNAs by zygotically expressed factors 1.462027e-01 0.835
R-HSA-8948700 Competing endogenous RNAs (ceRNAs) regulate PTEN translation 1.711496e-01 0.767
R-HSA-111447 Activation of BAD and translocation to mitochondria 1.711496e-01 0.767
R-HSA-77595 Processing of Intronless Pre-mRNAs 1.873770e-01 0.727
R-HSA-9909620 Regulation of PD-L1(CD274) translation 2.188907e-01 0.660
R-HSA-9938206 Developmental Lineage of Mammary Stem Cells 2.417263e-01 0.617
R-HSA-8943723 Regulation of PTEN mRNA translation 2.491897e-01 0.603
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 1.628421e-01 0.788
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 1.909493e-01 0.719
R-HSA-141424 Amplification of signal from the kinetochores 2.377542e-01 0.624
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 2.377542e-01 0.624
R-HSA-9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 2.595880e-01 0.586
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 1.389508e-01 0.857
R-HSA-156902 Peptide chain elongation 2.486628e-01 0.604
R-HSA-6803529 FGFR2 alternative splicing 2.417263e-01 0.617
R-HSA-877300 Interferon gamma signaling 2.550398e-01 0.593
R-HSA-72737 Cap-dependent Translation Initiation 1.384646e-01 0.859
R-HSA-72613 Eukaryotic Translation Initiation 1.384646e-01 0.859
R-HSA-9764562 Regulation of CDH1 mRNA translation by microRNAs 1.629155e-01 0.788
R-HSA-918233 TRAF3-dependent IRF activation pathway 1.873770e-01 0.727
R-HSA-9924644 Developmental Lineages of the Mammary Gland 1.873986e-01 0.727
R-HSA-9703465 Signaling by FLT3 fusion proteins 2.711449e-01 0.567
R-HSA-3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists 1.377224e-01 0.861
R-HSA-8934593 Regulation of RUNX1 Expression and Activity 2.711449e-01 0.567
R-HSA-380615 Serotonin clearance from the synaptic cleft 1.462027e-01 0.835
R-HSA-877312 Regulation of IFNG signaling 1.462027e-01 0.835
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 1.546002e-01 0.811
R-HSA-4641263 Regulation of FZD by ubiquitination 1.953719e-01 0.709
R-HSA-75067 Processing of Capped Intronless Pre-mRNA 2.565802e-01 0.591
R-HSA-9839394 TGFBR3 expression 2.638983e-01 0.579
R-HSA-73856 RNA Polymerase II Transcription Termination 1.490951e-01 0.827
R-HSA-199992 trans-Golgi Network Vesicle Budding 1.873986e-01 0.727
R-HSA-156842 Eukaryotic Translation Elongation 2.668754e-01 0.574
R-HSA-9711097 Cellular response to starvation 2.524035e-01 0.598
R-HSA-156711 Polo-like kinase mediated events 2.032887e-01 0.692
R-HSA-429914 Deadenylation-dependent mRNA decay 1.423151e-01 0.847
R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs 2.032887e-01 0.692
R-HSA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1 1.377224e-01 0.861
R-HSA-180689 APOBEC3G mediated resistance to HIV-1 infection 1.377224e-01 0.861
R-HSA-5357786 TNFR1-induced proapoptotic signaling 2.265775e-01 0.645
R-HSA-9842663 Signaling by LTK 1.462027e-01 0.835
R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands 1.629155e-01 0.788
R-HSA-168273 Influenza Viral RNA Transcription and Replication 2.445198e-01 0.612
R-HSA-5689603 UCH proteinases 2.016539e-01 0.695
R-HSA-8943724 Regulation of PTEN gene transcription 1.456968e-01 0.837
R-HSA-113510 E2F mediated regulation of DNA replication 2.111280e-01 0.675
R-HSA-8953854 Metabolism of RNA 2.266638e-01 0.645
R-HSA-3134975 Regulation of innate immune responses to cytosolic DNA 1.873770e-01 0.727
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 1.803263e-01 0.744
R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specif... 2.417263e-01 0.617
R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors 1.546002e-01 0.811
R-HSA-164938 Nef-mediates down modulation of cell surface receptors by recruiting them to cla... 1.953719e-01 0.709
R-HSA-9824594 Regulation of MITF-M-dependent genes involved in apoptosis 2.265775e-01 0.645
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 2.711449e-01 0.567
R-HSA-162909 Host Interactions of HIV factors 1.568837e-01 0.804
R-HSA-9768759 Regulation of NPAS4 gene expression 1.953719e-01 0.709
R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis 2.491897e-01 0.603
R-HSA-2219528 PI3K/AKT Signaling in Cancer 1.429974e-01 0.845
R-HSA-162906 HIV Infection 2.285149e-01 0.641
R-HSA-2028269 Signaling by Hippo 1.953719e-01 0.709
R-HSA-162587 HIV Life Cycle 2.497712e-01 0.602
R-HSA-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases 1.793031e-01 0.746
R-HSA-6802957 Oncogenic MAPK signaling 2.341234e-01 0.631
R-HSA-9034015 Signaling by NTRK3 (TRKC) 2.341891e-01 0.630
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 2.366779e-01 0.626
R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus 2.711449e-01 0.567
R-HSA-1280218 Adaptive Immune System 1.704189e-01 0.768
R-HSA-418990 Adherens junctions interactions 2.098865e-01 0.678
R-HSA-5357801 Programmed Cell Death 1.838257e-01 0.736
R-HSA-373753 Nephrin family interactions 2.188907e-01 0.660
R-HSA-5669034 TNFs bind their physiological receptors 2.565802e-01 0.591
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 2.417263e-01 0.617
R-HSA-1500931 Cell-Cell communication 2.393004e-01 0.621
R-HSA-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus 2.417263e-01 0.617
R-HSA-6783783 Interleukin-10 signaling 2.088288e-01 0.680
R-HSA-5633007 Regulation of TP53 Activity 2.576802e-01 0.589
R-HSA-9690406 Transcriptional regulation of testis differentiation 1.873770e-01 0.727
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 1.622589e-01 0.790
R-HSA-1222556 ROS and RNS production in phagocytes 1.945091e-01 0.711
R-HSA-1266695 Interleukin-7 signaling 2.638983e-01 0.579
R-HSA-982772 Growth hormone receptor signaling 2.491897e-01 0.603
R-HSA-109582 Hemostasis 2.736164e-01 0.563
R-HSA-9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... 2.778056e-01 0.556
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 2.778056e-01 0.556
R-HSA-5357956 TNFR1-induced NF-kappa-B signaling pathway 2.783206e-01 0.555
R-HSA-3928663 EPHA-mediated growth cone collapse 2.783206e-01 0.555
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 2.783206e-01 0.555
R-HSA-445095 Interaction between L1 and Ankyrins 2.783206e-01 0.555
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 2.783206e-01 0.555
R-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes 2.783206e-01 0.555
R-HSA-421270 Cell-cell junction organization 2.799747e-01 0.553
R-HSA-72689 Formation of a pool of free 40S subunits 2.814473e-01 0.551
R-HSA-72764 Eukaryotic Translation Termination 2.814473e-01 0.551
R-HSA-392499 Metabolism of proteins 2.833367e-01 0.548
R-HSA-171319 Telomere Extension By Telomerase 2.854260e-01 0.545
R-HSA-5620971 Pyroptosis 2.854260e-01 0.545
R-HSA-8957275 Post-translational protein phosphorylation 2.923629e-01 0.534
R-HSA-392154 Nitric oxide stimulates guanylate cyclase 2.924620e-01 0.534
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 2.994291e-01 0.524
R-HSA-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 2.994291e-01 0.524
R-HSA-112311 Neurotransmitter clearance 2.994291e-01 0.524
R-HSA-69618 Mitotic Spindle Checkpoint 2.996289e-01 0.523
R-HSA-1266738 Developmental Biology 3.003443e-01 0.522
R-HSA-2408557 Selenocysteine synthesis 3.032576e-01 0.518
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 3.063280e-01 0.514
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 3.063280e-01 0.514
R-HSA-9833109 Evasion by RSV of host interferon responses 3.063280e-01 0.514
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling 3.063280e-01 0.514
R-HSA-9734767 Developmental Cell Lineages 3.063864e-01 0.514
R-HSA-9842860 Regulation of endogenous retroelements 3.068831e-01 0.513
R-HSA-192823 Viral mRNA Translation 3.105050e-01 0.508
R-HSA-168255 Influenza Infection 3.110771e-01 0.507
R-HSA-4791275 Signaling by WNT in cancer 3.131594e-01 0.504
R-HSA-111465 Apoptotic cleavage of cellular proteins 3.131594e-01 0.504
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 3.141232e-01 0.503
R-HSA-1855170 IPs transport between nucleus and cytosol 3.199239e-01 0.495
R-HSA-159227 Transport of the SLBP independent Mature mRNA 3.199239e-01 0.495
R-HSA-6804758 Regulation of TP53 Activity through Acetylation 3.199239e-01 0.495
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 3.199239e-01 0.495
R-HSA-5696398 Nucleotide Excision Repair 3.213471e-01 0.493
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 3.213471e-01 0.493
R-HSA-9692914 SARS-CoV-1-host interactions 3.249523e-01 0.488
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 3.266223e-01 0.486
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 3.266223e-01 0.486
R-HSA-5696394 DNA Damage Recognition in GG-NER 3.266223e-01 0.486
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 3.285526e-01 0.483
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 3.285526e-01 0.483
R-HSA-9700206 Signaling by ALK in cancer 3.285526e-01 0.483
R-HSA-1236975 Antigen processing-Cross presentation 3.321479e-01 0.479
R-HSA-9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 3.332550e-01 0.477
R-HSA-203615 eNOS activation 3.332550e-01 0.477
R-HSA-9735869 SARS-CoV-1 modulates host translation machinery 3.332550e-01 0.477
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 3.332550e-01 0.477
R-HSA-180746 Nuclear import of Rev protein 3.332550e-01 0.477
R-HSA-901042 Calnexin/calreticulin cycle 3.332550e-01 0.477
R-HSA-73857 RNA Polymerase II Transcription 3.333464e-01 0.477
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 3.393220e-01 0.469
R-HSA-166166 MyD88-independent TLR4 cascade 3.393220e-01 0.469
R-HSA-446728 Cell junction organization 3.397455e-01 0.469
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 3.398229e-01 0.469
R-HSA-69205 G1/S-Specific Transcription 3.463264e-01 0.461
R-HSA-432720 Lysosome Vesicle Biogenesis 3.463264e-01 0.461
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 3.463264e-01 0.461
R-HSA-9682385 FLT3 signaling in disease 3.463264e-01 0.461
R-HSA-6804757 Regulation of TP53 Degradation 3.463264e-01 0.461
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 3.567671e-01 0.448
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 3.571515e-01 0.447
R-HSA-202131 Metabolism of nitric oxide: NOS3 activation and regulation 3.591431e-01 0.445
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 3.591431e-01 0.445
R-HSA-8875878 MET promotes cell motility 3.591431e-01 0.445
R-HSA-4420097 VEGFA-VEGFR2 Pathway 3.642363e-01 0.439
R-HSA-909733 Interferon alpha/beta signaling 3.642363e-01 0.439
R-HSA-168276 NS1 Mediated Effects on Host Pathways 3.654575e-01 0.437
R-HSA-6806003 Regulation of TP53 Expression and Degradation 3.654575e-01 0.437
R-HSA-201556 Signaling by ALK 3.654575e-01 0.437
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 3.717101e-01 0.430
R-HSA-9843743 Transcriptional regulation of brown and beige adipocyte differentiation 3.717101e-01 0.430
R-HSA-9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 3.717101e-01 0.430
R-HSA-177243 Interactions of Rev with host cellular proteins 3.717101e-01 0.430
R-HSA-9604323 Negative regulation of NOTCH4 signaling 3.717101e-01 0.430
R-HSA-376176 Signaling by ROBO receptors 3.754990e-01 0.425
R-HSA-5218920 VEGFR2 mediated vascular permeability 3.779014e-01 0.423
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 3.779014e-01 0.423
R-HSA-8853884 Transcriptional Regulation by VENTX 3.779014e-01 0.423
R-HSA-68875 Mitotic Prophase 3.818164e-01 0.418
R-HSA-5610780 Degradation of GLI1 by the proteasome 3.840321e-01 0.416
R-HSA-6811438 Intra-Golgi traffic 3.840321e-01 0.416
R-HSA-442660 SLC-mediated transport of neurotransmitters 3.840321e-01 0.416
R-HSA-212436 Generic Transcription Pathway 3.851592e-01 0.414
R-HSA-73886 Chromosome Maintenance 3.853083e-01 0.414
R-HSA-9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells 3.901028e-01 0.409
R-HSA-73762 RNA Polymerase I Transcription Initiation 3.901028e-01 0.409
R-HSA-9816359 Maternal to zygotic transition (MZT) 3.922666e-01 0.406
R-HSA-8854214 TBC/RABGAPs 3.961140e-01 0.402
R-HSA-194138 Signaling by VEGF 4.026376e-01 0.395
R-HSA-74160 Gene expression (Transcription) 4.075210e-01 0.390
R-HSA-774815 Nucleosome assembly 4.079604e-01 0.389
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 4.079604e-01 0.389
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 4.079604e-01 0.389
R-HSA-2299718 Condensation of Prophase Chromosomes 4.137967e-01 0.383
R-HSA-5357905 Regulation of TNFR1 signaling 4.137967e-01 0.383
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 4.137967e-01 0.383
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex 4.137967e-01 0.383
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 4.137967e-01 0.383
R-HSA-9839373 Signaling by TGFBR3 4.137967e-01 0.383
R-HSA-75153 Apoptotic execution phase 4.137967e-01 0.383
R-HSA-168256 Immune System 4.148814e-01 0.382
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 4.195758e-01 0.377
R-HSA-1474165 Reproduction 4.231256e-01 0.374
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 4.252983e-01 0.371
R-HSA-5663205 Infectious disease 4.261166e-01 0.370
R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle 4.309647e-01 0.366
R-HSA-109704 PI3K Cascade 4.365756e-01 0.360
R-HSA-9705683 SARS-CoV-2-host interactions 4.438720e-01 0.353
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 4.476330e-01 0.349
R-HSA-9634815 Transcriptional Regulation by NPAS4 4.476330e-01 0.349
R-HSA-9639288 Amino acids regulate mTORC1 4.530806e-01 0.344
R-HSA-9948299 Ribosome-associated quality control 4.531667e-01 0.344
R-HSA-9754678 SARS-CoV-2 modulates host translation machinery 4.584748e-01 0.339
R-HSA-3214815 HDACs deacetylate histones 4.638161e-01 0.334
R-HSA-9012852 Signaling by NOTCH3 4.638161e-01 0.334
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 4.691050e-01 0.329
R-HSA-75893 TNF signaling 4.691050e-01 0.329
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 4.691050e-01 0.329
R-HSA-3299685 Detoxification of Reactive Oxygen Species 4.691050e-01 0.329
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 4.694709e-01 0.328
R-HSA-8856828 Clathrin-mediated endocytosis 4.726973e-01 0.325
R-HSA-112399 IRS-mediated signalling 4.743421e-01 0.324
R-HSA-2980766 Nuclear Envelope Breakdown 4.743421e-01 0.324
R-HSA-6782135 Dual incision in TC-NER 4.795279e-01 0.319
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 4.795279e-01 0.319
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 4.795279e-01 0.319
R-HSA-194441 Metabolism of non-coding RNA 4.846628e-01 0.315
R-HSA-191859 snRNP Assembly 4.846628e-01 0.315
R-HSA-180786 Extension of Telomeres 4.846628e-01 0.315
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 4.886516e-01 0.311
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 4.897474e-01 0.310
R-HSA-2428928 IRS-related events triggered by IGF1R 4.947821e-01 0.306
R-HSA-168325 Viral Messenger RNA Synthesis 4.947821e-01 0.306
R-HSA-211976 Endogenous sterols 4.947821e-01 0.306
R-HSA-9679191 Potential therapeutics for SARS 4.949491e-01 0.305
R-HSA-375165 NCAM signaling for neurite out-growth 4.997675e-01 0.301
R-HSA-6784531 tRNA processing in the nucleus 4.997675e-01 0.301
R-HSA-9707616 Heme signaling 4.997675e-01 0.301
R-HSA-9616222 Transcriptional regulation of granulopoiesis 4.997675e-01 0.301
R-HSA-1268020 Mitochondrial protein import 4.997675e-01 0.301
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 4.997675e-01 0.301
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 4.997675e-01 0.301
R-HSA-5693532 DNA Double-Strand Break Repair 5.043036e-01 0.297
R-HSA-74751 Insulin receptor signalling cascade 5.095920e-01 0.293
R-HSA-2428924 IGF1R signaling cascade 5.095920e-01 0.293
R-HSA-211981 Xenobiotics 5.095920e-01 0.293
R-HSA-6798695 Neutrophil degranulation 5.110368e-01 0.292
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 5.144321e-01 0.289
R-HSA-9610379 HCMV Late Events 5.166021e-01 0.287
R-HSA-73894 DNA Repair 5.185221e-01 0.285
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 5.286694e-01 0.277
R-HSA-5218859 Regulated Necrosis 5.286694e-01 0.277
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 5.286694e-01 0.277
R-HSA-2408522 Selenoamino acid metabolism 5.376364e-01 0.270
R-HSA-9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins 5.379298e-01 0.269
R-HSA-204005 COPII-mediated vesicle transport 5.379298e-01 0.269
R-HSA-69202 Cyclin E associated events during G1/S transition 5.379298e-01 0.269
R-HSA-9764560 Regulation of CDH1 Gene Transcription 5.379298e-01 0.269
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 5.424919e-01 0.266
R-HSA-5632684 Hedgehog 'on' state 5.424919e-01 0.266
R-HSA-3000178 ECM proteoglycans 5.424919e-01 0.266
R-HSA-8978934 Metabolism of cofactors 5.424919e-01 0.266
R-HSA-5578749 Transcriptional regulation by small RNAs 5.470093e-01 0.262
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 5.470093e-01 0.262
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 5.470093e-01 0.262
R-HSA-1643685 Disease 5.474070e-01 0.262
R-HSA-4086398 Ca2+ pathway 5.514823e-01 0.258
R-HSA-9013694 Signaling by NOTCH4 5.559115e-01 0.255
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 5.580379e-01 0.253
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 5.602971e-01 0.252
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes 5.602971e-01 0.252
R-HSA-8852135 Protein ubiquitination 5.602971e-01 0.252
R-HSA-73854 RNA Polymerase I Promoter Clearance 5.646398e-01 0.248
R-HSA-1980143 Signaling by NOTCH1 5.646398e-01 0.248
R-HSA-9764265 Regulation of CDH1 Expression and Function 5.665850e-01 0.247
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 5.665850e-01 0.247
R-HSA-983169 Class I MHC mediated antigen processing & presentation 5.668559e-01 0.247
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 5.689398e-01 0.245
R-HSA-9678108 SARS-CoV-1 Infection 5.722172e-01 0.242
R-HSA-383280 Nuclear Receptor transcription pathway 5.731976e-01 0.242
R-HSA-73864 RNA Polymerase I Transcription 5.731976e-01 0.242
R-HSA-9659379 Sensory processing of sound 5.774136e-01 0.239
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 5.815883e-01 0.235
R-HSA-5654738 Signaling by FGFR2 5.815883e-01 0.235
R-HSA-6806834 Signaling by MET 5.815883e-01 0.235
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 5.938678e-01 0.226
R-HSA-201681 TCF dependent signaling in response to WNT 5.942167e-01 0.226
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 5.978809e-01 0.223
R-HSA-5687128 MAPK6/MAPK4 signaling 6.018546e-01 0.221
R-HSA-8868773 rRNA processing in the nucleus and cytosol 6.075351e-01 0.216
R-HSA-195721 Signaling by WNT 6.098417e-01 0.215
R-HSA-70268 Pyruvate metabolism 6.135430e-01 0.212
R-HSA-168898 Toll-like Receptor Cascades 6.153669e-01 0.211
R-HSA-1236974 ER-Phagosome pathway 6.211452e-01 0.207
R-HSA-74752 Signaling by Insulin receptor 6.359066e-01 0.197
R-HSA-2682334 EPH-Ephrin signaling 6.359066e-01 0.197
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 6.430715e-01 0.192
R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 6.500963e-01 0.187
R-HSA-157579 Telomere Maintenance 6.569837e-01 0.182
R-HSA-190236 Signaling by FGFR 6.603767e-01 0.180
R-HSA-3214847 HATs acetylate histones 6.637363e-01 0.178
R-HSA-70171 Glycolysis 6.670630e-01 0.176
R-HSA-9009391 Extra-nuclear estrogen signaling 6.703569e-01 0.174
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 6.736184e-01 0.172
R-HSA-1483255 PI Metabolism 6.736184e-01 0.172
R-HSA-9679506 SARS-CoV Infections 6.754702e-01 0.170
R-HSA-9860931 Response of endothelial cells to shear stress 6.800456e-01 0.167
R-HSA-9833110 RSV-host interactions 6.832118e-01 0.165
R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins 6.832118e-01 0.165
R-HSA-418346 Platelet homeostasis 6.894513e-01 0.161
R-HSA-211000 Gene Silencing by RNA 6.925250e-01 0.160
R-HSA-8878171 Transcriptional regulation by RUNX1 7.001696e-01 0.155
R-HSA-5683057 MAPK family signaling cascades 7.047105e-01 0.152
R-HSA-1483249 Inositol phosphate metabolism 7.074462e-01 0.150
R-HSA-9694516 SARS-CoV-2 Infection 7.081833e-01 0.150
R-HSA-72312 rRNA processing 7.127020e-01 0.147
R-HSA-9855142 Cellular responses to mechanical stimuli 7.132111e-01 0.147
R-HSA-3247509 Chromatin modifying enzymes 7.167817e-01 0.145
R-HSA-8939211 ESR-mediated signaling 7.228104e-01 0.141
R-HSA-70326 Glucose metabolism 7.271344e-01 0.138
R-HSA-9007101 Rab regulation of trafficking 7.271344e-01 0.138
R-HSA-3371556 Cellular response to heat stress 7.377876e-01 0.132
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 7.429582e-01 0.129
R-HSA-4839726 Chromatin organization 7.458584e-01 0.127
R-HSA-69206 G1/S Transition 7.505247e-01 0.125
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 7.537926e-01 0.123
R-HSA-114608 Platelet degranulation 7.554456e-01 0.122
R-HSA-187037 Signaling by NTRK1 (TRKA) 7.578698e-01 0.120
R-HSA-69620 Cell Cycle Checkpoints 7.620564e-01 0.118
R-HSA-199418 Negative regulation of the PI3K/AKT network 7.626468e-01 0.118
R-HSA-9843745 Adipogenesis 7.673300e-01 0.115
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 7.719215e-01 0.112
R-HSA-9018519 Estrogen-dependent gene expression 7.808360e-01 0.107
R-HSA-3858494 Beta-catenin independent WNT signaling 7.808360e-01 0.107
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 7.830100e-01 0.106
R-HSA-162599 Late Phase of HIV Life Cycle 7.956111e-01 0.099
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 8.009636e-01 0.096
R-HSA-166520 Signaling by NTRKs 8.074848e-01 0.093
R-HSA-69242 S Phase 8.074848e-01 0.093
R-HSA-5673001 RAF/MAP kinase cascade 8.112056e-01 0.091
R-HSA-9856651 MITF-M-dependent gene expression 8.112884e-01 0.091
R-HSA-9609507 Protein localization 8.168541e-01 0.088
R-HSA-1989781 PPARA activates gene expression 8.204736e-01 0.086
R-HSA-5684996 MAPK1/MAPK3 signaling 8.209782e-01 0.086
R-HSA-72766 Translation 8.239399e-01 0.084
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 8.240221e-01 0.084
R-HSA-9006936 Signaling by TGFB family members 8.292145e-01 0.081
R-HSA-211897 Cytochrome P450 - arranged by substrate type 8.407456e-01 0.075
R-HSA-5619102 SLC transporter disorders 8.407456e-01 0.075
R-HSA-72306 tRNA processing 8.469839e-01 0.072
R-HSA-9909648 Regulation of PD-L1(CD274) expression 8.500114e-01 0.071
R-HSA-212165 Epigenetic regulation of gene expression 8.545752e-01 0.068
R-HSA-389948 Co-inhibition by PD-1 8.866450e-01 0.052
R-HSA-9006931 Signaling by Nuclear Receptors 8.939168e-01 0.049
R-HSA-9730414 MITF-M-regulated melanocyte development 9.014739e-01 0.045
R-HSA-168249 Innate Immune System 9.234921e-01 0.035
R-HSA-5619115 Disorders of transmembrane transporters 9.299427e-01 0.032
R-HSA-388841 Regulation of T cell activation by CD28 family 9.359974e-01 0.029
R-HSA-9711123 Cellular response to chemical stress 9.432688e-01 0.025
R-HSA-76002 Platelet activation, signaling and aggregation 9.465904e-01 0.024
R-HSA-211945 Phase I - Functionalization of compounds 9.486967e-01 0.023
R-HSA-449147 Signaling by Interleukins 9.559645e-01 0.020
R-HSA-1483257 Phospholipid metabolism 9.567654e-01 0.019
R-HSA-1474244 Extracellular matrix organization 9.699256e-01 0.013
R-HSA-1428517 Aerobic respiration and respiratory electron transport 9.728140e-01 0.012
R-HSA-196854 Metabolism of vitamins and cofactors 9.784533e-01 0.009
R-HSA-425407 SLC-mediated transmembrane transport 9.847293e-01 0.007
R-HSA-388396 GPCR downstream signalling 9.862377e-01 0.006
R-HSA-71291 Metabolism of amino acids and derivatives 9.878913e-01 0.005
R-HSA-382551 Transport of small molecules 9.905192e-01 0.004
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 9.915269e-01 0.004
R-HSA-372790 Signaling by GPCR 9.930184e-01 0.003
R-HSA-211859 Biological oxidations 9.957645e-01 0.002
R-HSA-556833 Metabolism of lipids 9.999972e-01 0.000
R-HSA-9709957 Sensory Perception 9.999976e-01 0.000
R-HSA-1430728 Metabolism 1.000000e+00 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
GAKGAK 0.742 0.091 1 0.835
MPSK1MPSK1 0.732 0.248 1 0.754
MAKMAK 0.731 0.274 -2 0.849
TAK1TAK1 0.729 0.018 1 0.739
GCKGCK 0.728 0.045 1 0.715
P38BP38B 0.724 0.178 1 0.556
LKB1LKB1 0.722 0.030 -3 0.350
CK1DCK1D 0.722 0.390 -3 0.732
PKRPKR 0.722 -0.007 1 0.766
VRK2VRK2 0.721 -0.052 1 0.780
TNIKTNIK 0.721 0.007 3 0.772
ALPHAK3ALPHAK3 0.721 0.069 -1 0.705
BMPR1BBMPR1B 0.721 0.127 1 0.821
MST2MST2 0.721 -0.005 1 0.723
MOSMOS 0.719 0.151 1 0.835
P38AP38A 0.719 0.173 1 0.621
MINKMINK 0.719 -0.018 1 0.700
OSR1OSR1 0.719 0.022 2 0.767
EEF2KEEF2K 0.718 0.033 3 0.727
VRK1VRK1 0.718 -0.040 2 0.789
KHS1KHS1 0.718 0.015 1 0.678
TTKTTK 0.718 0.014 -2 0.449
CAMKK2CAMKK2 0.718 -0.048 -2 0.492
PASKPASK 0.717 0.041 -3 0.375
ICKICK 0.717 0.203 -3 0.327
MEK1MEK1 0.717 0.009 2 0.787
MST1MST1 0.717 -0.024 1 0.699
TAO3TAO3 0.717 0.025 1 0.698
CAMKK1CAMKK1 0.716 -0.063 -2 0.477
NEK1NEK1 0.716 -0.071 1 0.720
LRRK2LRRK2 0.716 -0.089 2 0.831
GRK7GRK7 0.715 0.148 1 0.722
NEK5NEK5 0.715 -0.030 1 0.758
PBKPBK 0.715 0.039 1 0.782
KHS2KHS2 0.715 0.008 1 0.692
HPK1HPK1 0.714 -0.007 1 0.693
ASK1ASK1 0.714 -0.043 1 0.648
MEKK2MEKK2 0.713 0.017 2 0.771
MST3MST3 0.713 0.042 2 0.835
CK1A2CK1A2 0.713 0.381 -3 0.726
PRP4PRP4 0.713 0.024 -3 0.326
CDKL1CDKL1 0.713 0.113 -3 0.307
MAP3K15MAP3K15 0.712 0.012 1 0.662
HGKHGK 0.712 -0.033 3 0.765
ALK4ALK4 0.712 -0.000 -2 0.455
DLKDLK 0.712 0.064 1 0.753
BMPR2BMPR2 0.712 -0.056 -2 0.526
BIKEBIKE 0.712 0.026 1 0.755
BRAFBRAF 0.711 -0.076 -4 0.765
MYO3BMYO3B 0.711 -0.035 2 0.825
DAPK2DAPK2 0.711 -0.050 -3 0.337
PDK1PDK1 0.710 -0.068 1 0.708
ATRATR 0.710 0.059 1 0.755
CK1ECK1E 0.709 0.404 -3 0.721
ALK2ALK2 0.709 0.011 -2 0.424
NIKNIK 0.709 -0.080 -3 0.359
TAO2TAO2 0.708 -0.077 2 0.838
MEK5MEK5 0.708 -0.087 2 0.791
PRPKPRPK 0.708 0.013 -1 0.792
JNK2JNK2 0.708 0.066 1 0.507
ACVR2BACVR2B 0.707 0.039 -2 0.420
CAMLCKCAMLCK 0.706 -0.046 -2 0.530
BMPR1ABMPR1A 0.706 0.072 1 0.797
MYO3AMYO3A 0.706 -0.054 1 0.673
LATS1LATS1 0.706 -0.027 -3 0.332
GRK6GRK6 0.705 0.138 1 0.794
MLK2MLK2 0.705 0.075 2 0.802
P38DP38D 0.705 0.101 1 0.466
YSK4YSK4 0.705 -0.031 1 0.680
CDKL5CDKL5 0.704 0.186 -3 0.292
JNK3JNK3 0.704 0.045 1 0.544
AAK1AAK1 0.704 0.047 1 0.673
DAPK3DAPK3 0.704 -0.052 -3 0.323
GRK5GRK5 0.704 0.138 -3 0.469
ERK5ERK5 0.704 0.131 1 0.782
NEK11NEK11 0.704 -0.040 1 0.692
MEKK1MEKK1 0.704 -0.068 1 0.709
TGFBR1TGFBR1 0.704 0.003 -2 0.423
NEK4NEK4 0.703 -0.085 1 0.698
SKMLCKSKMLCK 0.703 0.049 -2 0.548
MEKK6MEKK6 0.703 -0.065 1 0.709
NEK8NEK8 0.703 -0.082 2 0.806
MOKMOK 0.702 0.153 1 0.673
ACVR2AACVR2A 0.702 0.029 -2 0.408
STLK3STLK3 0.701 -0.094 1 0.643
MEKK3MEKK3 0.701 -0.002 1 0.717
ROCK2ROCK2 0.701 -0.043 -3 0.308
DMPK1DMPK1 0.701 -0.053 -3 0.294
COTCOT 0.701 0.141 2 0.832
ANKRD3ANKRD3 0.701 -0.106 1 0.777
YSK1YSK1 0.700 -0.077 2 0.804
PIM1PIM1 0.700 0.024 -3 0.339
ERK1ERK1 0.699 0.134 1 0.537
PIM3PIM3 0.698 0.051 -3 0.349
GRK1GRK1 0.698 0.178 -2 0.480
NLKNLK 0.698 0.005 1 0.716
CAMK1BCAMK1B 0.698 -0.073 -3 0.337
GRK2GRK2 0.698 0.088 -2 0.408
RAF1RAF1 0.697 0.011 1 0.760
CDC7CDC7 0.697 0.158 1 0.829
CLK3CLK3 0.697 0.110 1 0.744
CHAK2CHAK2 0.697 0.068 -1 0.742
MLK1MLK1 0.696 0.081 2 0.796
ZAKZAK 0.696 -0.055 1 0.684
HIPK1HIPK1 0.696 0.047 1 0.616
MEK2MEK2 0.696 -0.170 2 0.765
P38GP38G 0.695 0.070 1 0.446
LOKLOK 0.695 -0.078 -2 0.487
TLK2TLK2 0.695 -0.005 1 0.702
SLKSLK 0.694 -0.047 -2 0.465
CDK1CDK1 0.692 0.081 1 0.538
DAPK1DAPK1 0.692 -0.058 -3 0.325
HIPK4HIPK4 0.691 0.161 1 0.682
MLK3MLK3 0.691 0.097 2 0.739
BUB1BUB1 0.690 0.013 -5 0.550
SMMLCKSMMLCK 0.690 -0.109 -3 0.307
MLK4MLK4 0.690 0.089 2 0.697
NEK9NEK9 0.689 -0.082 2 0.816
PIM2PIM2 0.688 -0.034 -3 0.267
CAMK2GCAMK2G 0.688 -0.035 2 0.774
DYRK2DYRK2 0.688 0.057 1 0.601
DYRK1ADYRK1A 0.687 0.079 1 0.613
MTORMTOR 0.687 0.106 1 0.679
CDK5CDK5 0.687 0.070 1 0.594
MASTLMASTL 0.687 -0.090 -2 0.528
ERK2ERK2 0.687 0.048 1 0.564
PERKPERK 0.686 -0.115 -2 0.467
JNK1JNK1 0.685 0.037 1 0.504
PLK1PLK1 0.685 -0.078 -2 0.450
HIPK2HIPK2 0.685 0.104 1 0.510
TLK1TLK1 0.683 -0.042 -2 0.442
DSTYKDSTYK 0.683 -0.051 2 0.859
TAO1TAO1 0.683 -0.090 1 0.609
GRK3GRK3 0.682 0.111 -2 0.369
PDHK4PDHK4 0.682 -0.138 1 0.757
ROCK1ROCK1 0.681 -0.075 -3 0.284
ERK7ERK7 0.680 0.043 2 0.556
NEK2NEK2 0.680 -0.115 2 0.806
CDK18CDK18 0.680 0.096 1 0.510
CK1G3CK1G3 0.679 0.297 -3 0.716
RIPK3RIPK3 0.679 0.007 3 0.637
PDHK1PDHK1 0.679 -0.158 1 0.736
CRIKCRIK 0.679 -0.071 -3 0.256
DNAPKDNAPK 0.679 -0.006 1 0.603
HASPINHASPIN 0.679 -0.005 -1 0.569
PKN3PKN3 0.679 -0.071 -3 0.321
CDK8CDK8 0.679 0.112 1 0.552
HIPK3HIPK3 0.679 0.022 1 0.596
PKCDPKCD 0.678 -0.030 2 0.774
GRK4GRK4 0.678 0.091 -2 0.466
WNK1WNK1 0.678 -0.049 -2 0.585
TSSK2TSSK2 0.678 -0.064 -5 0.555
PINK1PINK1 0.678 -0.131 1 0.740
P70S6KBP70S6KB 0.678 -0.067 -3 0.296
SMG1SMG1 0.677 -0.015 1 0.705
HRIHRI 0.677 -0.169 -2 0.485
GSK3AGSK3A 0.677 0.048 4 0.433
MRCKAMRCKA 0.677 -0.082 -3 0.283
CHK1CHK1 0.677 -0.131 -3 0.287
WNK4WNK4 0.677 -0.104 -2 0.599
DRAK1DRAK1 0.677 -0.039 1 0.757
IRAK4IRAK4 0.676 -0.071 1 0.727
TBK1TBK1 0.675 0.038 1 0.635
SGK1SGK1 0.675 -0.051 -3 0.221
MRCKBMRCKB 0.675 -0.073 -3 0.269
IKKAIKKA 0.675 0.051 -2 0.475
RIPK1RIPK1 0.675 -0.108 1 0.736
CDK3CDK3 0.675 0.058 1 0.480
PLK2PLK2 0.675 -0.017 -3 0.352
SGK3SGK3 0.674 -0.060 -3 0.285
IKKBIKKB 0.674 0.014 -2 0.464
ATMATM 0.674 -0.012 1 0.701
DYRK1BDYRK1B 0.673 0.009 1 0.549
PLK3PLK3 0.673 -0.067 2 0.719
CDK16CDK16 0.673 0.062 1 0.473
AMPKA1AMPKA1 0.673 -0.085 -3 0.341
CDK14CDK14 0.673 0.024 1 0.546
CHAK1CHAK1 0.673 -0.047 2 0.786
CDK17CDK17 0.672 0.053 1 0.454
AKT2AKT2 0.672 -0.054 -3 0.251
MST4MST4 0.672 -0.042 2 0.853
DCAMKL1DCAMKL1 0.671 -0.106 -3 0.298
PKN2PKN2 0.671 -0.073 -3 0.346
NUAK2NUAK2 0.671 -0.081 -3 0.344
NEK7NEK7 0.671 -0.110 -3 0.371
MYLK4MYLK4 0.671 -0.057 -2 0.450
NEK6NEK6 0.670 -0.053 -2 0.506
PAK1PAK1 0.670 -0.026 -2 0.519
CAMK2DCAMK2D 0.670 -0.079 -3 0.315
DYRK3DYRK3 0.669 -0.008 1 0.616
CDK19CDK19 0.669 0.120 1 0.517
RSK2RSK2 0.669 -0.041 -3 0.271
CK2A2CK2A2 0.669 0.082 1 0.753
NEK3NEK3 0.668 -0.186 1 0.655
CK1ACK1A 0.668 0.347 -3 0.727
YANK3YANK3 0.668 0.094 2 0.374
DYRK4DYRK4 0.668 0.034 1 0.525
IKKEIKKE 0.668 -0.019 1 0.626
MARK4MARK4 0.668 -0.084 4 0.802
CLK4CLK4 0.668 -0.045 -3 0.303
TSSK1TSSK1 0.667 -0.061 -3 0.334
SRPK1SRPK1 0.667 -0.015 -3 0.286
PAK2PAK2 0.667 -0.059 -2 0.503
GSK3BGSK3B 0.667 0.003 4 0.420
PKCAPKCA 0.667 -0.012 2 0.730
CK1G1CK1G1 0.667 0.333 -3 0.698
CDK2CDK2 0.667 -0.005 1 0.619
CDK6CDK6 0.667 0.008 1 0.524
CAMK2BCAMK2B 0.667 -0.026 2 0.737
MAPKAPK3MAPKAPK3 0.666 -0.065 -3 0.279
PKCZPKCZ 0.666 -0.036 2 0.769
YANK2YANK2 0.666 0.102 2 0.384
TTBK2TTBK2 0.666 -0.020 2 0.671
RSK4RSK4 0.665 -0.024 -3 0.276
ULK2ULK2 0.665 -0.140 2 0.749
HUNKHUNK 0.665 -0.138 2 0.752
CAMK2ACAMK2A 0.664 -0.023 2 0.763
PRKD1PRKD1 0.664 -0.008 -3 0.288
CDK4CDK4 0.663 0.003 1 0.494
P90RSKP90RSK 0.663 -0.060 -3 0.274
CDK7CDK7 0.663 0.053 1 0.569
SRPK3SRPK3 0.663 -0.047 -3 0.290
MAPKAPK2MAPKAPK2 0.663 -0.011 -3 0.273
TGFBR2TGFBR2 0.663 -0.100 -2 0.415
AMPKA2AMPKA2 0.663 -0.080 -3 0.317
CDK13CDK13 0.663 0.005 1 0.538
NDR1NDR1 0.663 -0.065 -3 0.331
PKACBPKACB 0.663 -0.020 -2 0.390
PDHK3_TYRPDHK3_TYR 0.662 0.190 4 0.900
CHK2CHK2 0.662 -0.091 -3 0.220
CAMK1DCAMK1D 0.662 -0.087 -3 0.238
SBKSBK 0.662 -0.057 -3 0.184
AKT1AKT1 0.662 -0.065 -3 0.261
IRE1IRE1 0.661 -0.032 1 0.725
NDR2NDR2 0.661 0.012 -3 0.345
MSK1MSK1 0.660 -0.054 -3 0.286
CK2A1CK2A1 0.660 0.075 1 0.732
PKCBPKCB 0.660 -0.028 2 0.735
WNK3WNK3 0.660 -0.155 1 0.721
AURBAURB 0.659 -0.050 -2 0.386
PKACGPKACG 0.659 -0.054 -2 0.446
IRE2IRE2 0.659 -0.056 2 0.722
DCAMKL2DCAMKL2 0.658 -0.127 -3 0.292
PDHK1_TYRPDHK1_TYR 0.658 0.184 -1 0.815
PDHK4_TYRPDHK4_TYR 0.658 0.154 2 0.852
BCKDKBCKDK 0.658 -0.045 -1 0.779
PAK3PAK3 0.658 -0.070 -2 0.503
AURAAURA 0.658 -0.037 -2 0.363
MAP2K6_TYRMAP2K6_TYR 0.658 0.155 -1 0.808
CAMK4CAMK4 0.658 -0.128 -3 0.336
MAP2K4_TYRMAP2K4_TYR 0.658 0.134 -1 0.809
CK1G2CK1G2 0.657 0.233 -3 0.714
CLK2CLK2 0.657 -0.001 -3 0.291
CDK12CDK12 0.657 -0.000 1 0.506
PKCGPKCG 0.657 -0.030 2 0.734
KISKIS 0.657 0.099 1 0.580
AURCAURC 0.657 -0.011 -2 0.388
PKCHPKCH 0.656 -0.084 2 0.713
PRKD2PRKD2 0.656 -0.029 -3 0.267
CDK10CDK10 0.656 0.014 1 0.536
MELKMELK 0.654 -0.133 -3 0.287
PKG2PKG2 0.654 -0.064 -2 0.401
QSKQSK 0.653 -0.074 4 0.769
MSK2MSK2 0.653 -0.074 -3 0.296
TXKTXK 0.653 0.150 1 0.841
PRKD3PRKD3 0.653 -0.086 -3 0.250
LATS2LATS2 0.653 -0.063 -5 0.505
CLK1CLK1 0.652 -0.058 -3 0.265
STK33STK33 0.652 -0.093 2 0.585
PKCEPKCE 0.652 -0.055 2 0.724
GCN2GCN2 0.651 -0.098 2 0.767
NIM1NIM1 0.651 -0.108 3 0.679
RSK3RSK3 0.651 -0.077 -3 0.258
EPHB4EPHB4 0.650 0.111 -1 0.809
CAMK1ACAMK1A 0.650 -0.074 -3 0.227
IRAK1IRAK1 0.650 -0.217 -1 0.653
MARK2MARK2 0.650 -0.101 4 0.696
QIKQIK 0.649 -0.150 -3 0.326
AKT3AKT3 0.649 -0.050 -3 0.230
BMPR2_TYRBMPR2_TYR 0.649 0.012 -1 0.798
FAM20CFAM20C 0.649 0.047 2 0.555
ABL2ABL2 0.649 0.123 -1 0.761
TESK1_TYRTESK1_TYR 0.649 0.009 3 0.798
PKACAPKACA 0.649 -0.053 -2 0.354
FGRFGR 0.648 0.103 1 0.840
CAMK1GCAMK1G 0.648 -0.109 -3 0.286
ULK1ULK1 0.648 -0.152 -3 0.353
CDK9CDK9 0.647 -0.040 1 0.545
P70S6KP70S6K 0.647 -0.100 -3 0.241
PRKXPRKX 0.647 -0.020 -3 0.273
ABL1ABL1 0.647 0.125 -1 0.755
MARK3MARK3 0.647 -0.076 4 0.721
SRPK2SRPK2 0.647 -0.040 -3 0.250
PKCIPKCI 0.645 -0.095 2 0.734
MAP2K7_TYRMAP2K7_TYR 0.645 -0.052 2 0.832
MARK1MARK1 0.645 -0.121 4 0.747
RIPK2RIPK2 0.645 -0.212 1 0.639
MNK1MNK1 0.644 -0.080 -2 0.487
SSTKSSTK 0.643 -0.096 4 0.755
PKMYT1_TYRPKMYT1_TYR 0.643 -0.055 3 0.767
PKCTPKCT 0.643 -0.093 2 0.721
YES1YES1 0.643 0.065 -1 0.790
MNK2MNK2 0.643 -0.066 -2 0.491
EPHA6EPHA6 0.642 0.018 -1 0.818
LIMK2_TYRLIMK2_TYR 0.641 -0.016 -3 0.338
SIKSIK 0.641 -0.100 -3 0.290
PINK1_TYRPINK1_TYR 0.641 -0.084 1 0.761
PLK4PLK4 0.641 -0.108 2 0.577
FERFER 0.641 0.032 1 0.842
BLKBLK 0.640 0.083 -1 0.781
LCKLCK 0.639 0.073 -1 0.774
EPHA4EPHA4 0.638 0.029 2 0.725
NUAK1NUAK1 0.638 -0.118 -3 0.288
EPHB2EPHB2 0.638 0.057 -1 0.792
FYNFYN 0.638 0.087 -1 0.754
EPHB3EPHB3 0.637 0.043 -1 0.808
CSF1RCSF1R 0.637 0.061 3 0.699
RETRET 0.637 -0.019 1 0.703
PHKG1PHKG1 0.637 -0.090 -3 0.335
SRMSSRMS 0.636 0.033 1 0.825
HCKHCK 0.635 0.024 -1 0.771
EPHB1EPHB1 0.635 0.013 1 0.806
TTBK1TTBK1 0.634 -0.083 2 0.593
PAK6PAK6 0.634 -0.056 -2 0.457
ROS1ROS1 0.633 -0.008 3 0.654
TYRO3TYRO3 0.633 -0.025 3 0.693
JAK2JAK2 0.633 -0.021 1 0.691
TNK2TNK2 0.633 0.031 3 0.672
ITKITK 0.632 0.014 -1 0.738
METMET 0.632 0.059 3 0.696
INSRRINSRR 0.632 0.007 3 0.633
KITKIT 0.631 0.031 3 0.702
MAPKAPK5MAPKAPK5 0.631 -0.142 -3 0.262
TYK2TYK2 0.631 -0.092 1 0.701
SYKSYK 0.631 0.085 -1 0.724
LIMK1_TYRLIMK1_TYR 0.630 -0.133 2 0.832
MST1RMST1R 0.630 -0.052 3 0.713
MERTKMERTK 0.629 0.028 3 0.683
PKN1PKN1 0.629 -0.104 -3 0.252
PTK2PTK2 0.629 0.066 -1 0.726
DDR1DDR1 0.629 -0.083 4 0.812
BMXBMX 0.628 0.029 -1 0.674
BRSK1BRSK1 0.628 -0.102 -3 0.293
JAK3JAK3 0.627 -0.043 1 0.692
EPHA7EPHA7 0.626 0.011 2 0.729
FLT1FLT1 0.626 0.019 -1 0.774
SRCSRC 0.625 0.045 -1 0.763
SNRKSNRK 0.625 -0.188 2 0.659
EPHA3EPHA3 0.624 -0.016 2 0.702
BRSK2BRSK2 0.624 -0.124 -3 0.303
LYNLYN 0.623 0.007 3 0.616
KDRKDR 0.623 -0.029 3 0.658
TECTEC 0.623 -0.015 -1 0.702
MATKMATK 0.623 0.012 -1 0.685
TNNI3K_TYRTNNI3K_TYR 0.622 -0.029 1 0.729
EPHA5EPHA5 0.622 0.008 2 0.705
JAK1JAK1 0.622 -0.030 1 0.633
PTK2BPTK2B 0.622 0.021 -1 0.741
BTKBTK 0.621 -0.063 -1 0.708
EPHA8EPHA8 0.620 0.006 -1 0.784
PTK6PTK6 0.620 -0.066 -1 0.690
PDGFRBPDGFRB 0.620 -0.090 3 0.700
PAK5PAK5 0.620 -0.075 -2 0.419
FLT3FLT3 0.619 -0.072 3 0.693
FGFR2FGFR2 0.619 -0.074 3 0.695
AXLAXL 0.619 -0.044 3 0.672
NTRK1NTRK1 0.619 -0.070 -1 0.776
FRKFRK 0.618 -0.004 -1 0.791
NTRK3NTRK3 0.618 -0.026 -1 0.747
LTKLTK 0.618 -0.052 3 0.646
ALKALK 0.617 -0.054 3 0.613
NEK10_TYRNEK10_TYR 0.617 -0.088 1 0.569
DDR2DDR2 0.616 0.004 3 0.630
CSKCSK 0.616 0.019 2 0.732
TNK1TNK1 0.616 -0.063 3 0.681
WEE1_TYRWEE1_TYR 0.615 -0.057 -1 0.679
ERBB2ERBB2 0.615 -0.047 1 0.684
PHKG2PHKG2 0.615 -0.136 -3 0.295
EGFREGFR 0.615 -0.009 1 0.602
INSRINSR 0.614 -0.040 3 0.608
EPHA1EPHA1 0.614 -0.036 3 0.667
ZAP70ZAP70 0.613 0.074 -1 0.643
FGFR4FGFR4 0.613 0.006 -1 0.726
FGFR3FGFR3 0.612 -0.053 3 0.663
PDGFRAPDGFRA 0.611 -0.125 3 0.700
NTRK2NTRK2 0.610 -0.110 3 0.644
FGFR1FGFR1 0.609 -0.122 3 0.660
PAK4PAK4 0.609 -0.064 -2 0.422
TEKTEK 0.609 -0.141 3 0.626
ERBB4ERBB4 0.608 0.025 1 0.647
EPHA2EPHA2 0.606 -0.029 -1 0.740
FLT4FLT4 0.605 -0.109 3 0.651
IGF1RIGF1R 0.603 -0.030 3 0.549
PKG1PKG1 0.603 -0.110 -2 0.325
FESFES 0.596 -0.020 -1 0.662
MUSKMUSK 0.591 -0.106 1 0.600