Motif 10 (n=127)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A2VDJ0 | TMEM131L | S1276 | ochoa | Transmembrane protein 131-like | [Isoform 1]: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation. {ECO:0000269|PubMed:23690469}. |
| A8MW92 | PHF20L1 | S313 | ochoa | PHD finger protein 20-like protein 1 | Is a negative regulator of proteasomal degradation of a set of methylated proteins, including DNMT1 and SOX2 (PubMed:24492612, PubMed:29358331). Involved in the maintainance of embryonic stem cells pluripotency, through the regulation of SOX2 levels (By similarity). {ECO:0000250|UniProtKB:Q8CCJ9, ECO:0000269|PubMed:24492612, ECO:0000269|PubMed:29358331}. |
| M0R1B8 | None | S23 | ochoa | Uncharacterized protein | None |
| O00204 | SULT2B1 | S318 | ochoa | Sulfotransferase 2B1 (EC 2.8.2.2) (Alcohol sulfotransferase) (Hydroxysteroid sulfotransferase 2) (Sulfotransferase family 2B member 1) (Sulfotransferase family cytosolic 2B member 1) (ST2B1) | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Responsible for the sulfation of cholesterol (PubMed:12145317, PubMed:19589875). Catalyzes sulfation of the 3beta-hydroxyl groups of steroids, such as, pregnenolone and dehydroepiandrosterone (DHEA) (PubMed:12145317, PubMed:16855051, PubMed:21855633, PubMed:9799594). Preferentially sulfonates cholesterol, while it also has significant activity with pregnenolone and DHEA (PubMed:12145317, PubMed:21855633). Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation (PubMed:28575648). {ECO:0000269|PubMed:12145317, ECO:0000269|PubMed:16855051, ECO:0000269|PubMed:19589875, ECO:0000269|PubMed:21855633, ECO:0000269|PubMed:28575648, ECO:0000269|PubMed:9799594}.; FUNCTION: [Isoform 2]: Sulfonates pregnenolone but not cholesterol. {ECO:0000269|PubMed:12145317}. |
| O00257 | CBX4 | S291 | ochoa | E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2) | E3 SUMO-protein ligase that catalyzes sumoylation of target proteins by promoting the transfer of SUMO from the E2 enzyme to the substrate (PubMed:12679040, PubMed:22825850). Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131 (PubMed:22825850). {ECO:0000269|PubMed:12679040, ECO:0000269|PubMed:22825850}.; FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:12167701, PubMed:19636380, PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167701, PubMed:19636380, PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). {ECO:0000250|UniProtKB:O55187, ECO:0000269|PubMed:12167701, ECO:0000269|PubMed:19636380, ECO:0000269|PubMed:21282530}. |
| O14976 | GAK | S834 | ochoa | Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26) | Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (PubMed:10625686). May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly (PubMed:18489706). {ECO:0000269|PubMed:10625686, ECO:0000269|PubMed:18489706}. |
| O15014 | ZNF609 | S758 | ochoa | Zinc finger protein 609 | Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}. |
| O43432 | EIF4G3 | S1409 | ochoa | Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:9418880). Functional homolog of EIF4G1 (PubMed:9418880). {ECO:0000269|PubMed:9418880}. |
| O43493 | TGOLN2 | S314 | ochoa | Trans-Golgi network integral membrane protein 2 (Trans-Golgi network glycoprotein 46) (TGN38 homolog) (hTGN46) (Trans-Golgi network glycoprotein 48) (hTGN48) (Trans-Golgi network glycoprotein 51) (hTGN51) (Trans-Golgi network protein 2) | May be involved in regulating membrane traffic to and from trans-Golgi network. |
| O60268 | KIAA0513 | S279 | ochoa | Uncharacterized protein KIAA0513 | None |
| O75154 | RAB11FIP3 | S451 | psp | Rab11 family-interacting protein 3 (FIP3) (FIP3-Rab11) (Rab11-FIP3) (Arfophilin-1) (EF hands-containing Rab-interacting protein) (Eferin) (MU-MB-17.148) | Downstream effector molecule for Rab11 GTPase which is involved in endocytic trafficking, cytokinesis and intracellular ciliogenesis by participating in membrane delivery (PubMed:15601896, PubMed:16148947, PubMed:17394487, PubMed:17628206, PubMed:18511905, PubMed:19327867, PubMed:20026645, PubMed:25673879, PubMed:26258637, PubMed:31204173). Recruited by Rab11 to endosomes where it links Rab11 to dynein motor complex (PubMed:20026645). The functional Rab11-RAB11FIP3-dynein complex regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endocytic recycling compartment (ERC) during interphase of cell cycle (PubMed:17394487, PubMed:20026645). Facilitates the interaction between dynein and dynactin and activates dynein processivity (PubMed:25035494). Binding with ASAP1 is needed to regulate the pericentrosomal localization of recycling endosomes (By similarity). The Rab11-RAB11FIP3 complex is also implicated in the transport during telophase of vesicles derived from recycling endosomes to the cleavage furrow via centrosome-anchored microtubules, where the vesicles function to deliver membrane during late cytokinesis and abscission (PubMed:15601896, PubMed:16148947). The recruitment of Rab11-RAB11FIP3-containing endosomes to the cleavage furrow and tethering to the midbody is co-mediated by RAB11FIP3 interaction with ARF6-exocyst and RACGAP1-MKLP1 tethering complexes (PubMed:17628206, PubMed:18511905). Also involved in the Rab11-Rabin8-Rab8 ciliogenesis cascade by facilitating the orderly assembly of a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which directs preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:26258637, PubMed:31204173). Also promotes the activity of Rab11 and ASAP1 in the ARF4-dependent Golgi-to-cilia transport of the sensory receptor rhodopsin (PubMed:25673879). Competes with WDR44 for binding to Rab11, which controls intracellular ciliogenesis pathway (PubMed:31204173). May play a role in breast cancer cell motility by regulating actin cytoskeleton (PubMed:19327867). {ECO:0000250|UniProtKB:Q8CHD8, ECO:0000269|PubMed:15601896, ECO:0000269|PubMed:16148947, ECO:0000269|PubMed:17394487, ECO:0000269|PubMed:17628206, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19327867, ECO:0000269|PubMed:20026645, ECO:0000269|PubMed:25035494, ECO:0000269|PubMed:25673879, ECO:0000269|PubMed:26258637, ECO:0000269|PubMed:31204173}. |
| O94819 | KBTBD11 | S93 | ochoa | Kelch repeat and BTB domain-containing protein 11 (Chronic myelogenous leukemia-associated protein) (Kelch domain-containing protein 7B) | None |
| O94819 | KBTBD11 | S107 | ochoa | Kelch repeat and BTB domain-containing protein 11 (Chronic myelogenous leukemia-associated protein) (Kelch domain-containing protein 7B) | None |
| O94953 | KDM4B | S566 | ochoa|psp | Lysine-specific demethylase 4B (EC 1.14.11.66) (JmjC domain-containing histone demethylation protein 3B) (Jumonji domain-containing protein 2B) ([histone H3]-trimethyl-L-lysine(9) demethylase 4B) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate (PubMed:16603238, PubMed:28262558). Plays a critical role in the development of the central nervous system (CNS). {ECO:0000250|UniProtKB:Q91VY5, ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}. |
| P04637 | TP53 | S20 | psp | Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53) | Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:35618207, PubMed:36634798, PubMed:38653238, PubMed:9840937). Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17189187, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:38653238, PubMed:9840937). Negatively regulates cell division by controlling expression of a set of genes required for this process (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:9840937). One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (PubMed:12524540, PubMed:17189187). Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (PubMed:12524540). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (PubMed:12524540). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492). {ECO:0000269|PubMed:11025664, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:15186775, ECO:0000269|PubMed:15340061, ECO:0000269|PubMed:17189187, ECO:0000269|PubMed:17317671, ECO:0000269|PubMed:17349958, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:20959462, ECO:0000269|PubMed:22726440, ECO:0000269|PubMed:24051492, ECO:0000269|PubMed:24652652, ECO:0000269|PubMed:35618207, ECO:0000269|PubMed:36634798, ECO:0000269|PubMed:38653238, ECO:0000269|PubMed:9840937}. |
| P07197 | NEFM | S615 | ochoa | Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P08553}. |
| P07197 | NEFM | S628 | ochoa | Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P08553}. |
| P07197 | NEFM | S667 | ochoa | Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P08553}. |
| P07197 | NEFM | S680 | ochoa | Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P08553}. |
| P09884 | POLA1 | S503 | ochoa | DNA polymerase alpha catalytic subunit (EC 2.7.7.7) (DNA polymerase alpha catalytic subunit p180) | Catalytic subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, a regulatory subunit POLA2 and two primase subunits PRIM1 and PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. The reason this transfer occurs is because the polymerase alpha has limited processivity and lacks intrinsic 3' exonuclease activity for proofreading error, and therefore is not well suited for replicating long complexes. In the cytosol, responsible for a substantial proportion of the physiological concentration of cytosolic RNA:DNA hybrids, which are necessary to prevent spontaneous activation of type I interferon responses (PubMed:27019227). {ECO:0000269|PubMed:26975377, ECO:0000269|PubMed:27019227, ECO:0000269|PubMed:31006512, ECO:0000269|PubMed:9518481}. |
| P0DPH7 | TUBA3C | T271 | ochoa | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P0DPH8 | TUBA3D | T271 | ochoa | Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P11137 | MAP2 | S1347 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| P12036 | NEFH | S503 | ochoa|psp | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P19246}. |
| P12036 | NEFH | S511 | ochoa | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P19246}. |
| P12036 | NEFH | S526 | ochoa | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P19246}. |
| P12036 | NEFH | S532 | ochoa | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P19246}. |
| P12036 | NEFH | S540 | ochoa | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P19246}. |
| P12036 | NEFH | S546 | ochoa | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P19246}. |
| P12036 | NEFH | S560 | ochoa | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P19246}. |
| P12036 | NEFH | S566 | ochoa | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P19246}. |
| P12036 | NEFH | S614 | ochoa | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P19246}. |
| P12036 | NEFH | S620 | ochoa | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P19246}. |
| P12036 | NEFH | S668 | ochoa | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P19246}. |
| P12036 | NEFH | S710 | ochoa | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P19246}. |
| P12036 | NEFH | S801 | ochoa | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P19246}. |
| P17028 | ZNF24 | S39 | ochoa | Zinc finger protein 24 (Retinoic acid suppression protein A) (RSG-A) (Zinc finger and SCAN domain-containing protein 3) (Zinc finger protein 191) (Zinc finger protein KOX17) | Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity). Has transcription repressor activity in vitro. {ECO:0000250, ECO:0000269|PubMed:10585455}. |
| P17275 | JUNB | S259 | ochoa|psp | Transcription factor JunB (Transcription factor AP-1 subunit JunB) | Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[GC]TCA-3'. Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to an AP-1 consensus sequence and its transcriptional activity (By similarity). {ECO:0000250|UniProtKB:P09450}. |
| P18031 | PTPN1 | S352 | ochoa|psp | Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) | Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139, ECO:0000269|PubMed:22169477}. |
| P18583 | SON | S1556 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P36507 | MAP2K2 | S23 | ochoa | Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2) | Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126). {ECO:0000250|UniProtKB:Q63932, ECO:0000269|PubMed:29433126}. |
| P46379 | BAG6 | S973 | ochoa | Large proline-rich protein BAG6 (BAG family molecular chaperone regulator 6) (BCL2-associated athanogene 6) (BAG-6) (HLA-B-associated transcript 3) (Protein G3) (Protein Scythe) | ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins (PubMed:21636303). Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20516149, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20516149, PubMed:20676083, PubMed:25535373, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome (PubMed:24981174, PubMed:27193484, PubMed:28104892). SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins (PubMed:23129660, PubMed:25179605, PubMed:27193484). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate in the production of antigenic peptides and play a role in antigen presentation in immune response (By similarity). BAG6 is also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. BAG6 may ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress (PubMed:26565908). By inhibiting the polyubiquitination and subsequent proteasomal degradation of HSPA2 it may also play a role in the assembly of the synaptonemal complex during spermatogenesis (By similarity). Also positively regulates apoptosis by interacting with and stabilizing the proapoptotic factor AIFM1 (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:Q9Z1R2, ECO:0000269|PubMed:20516149, ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:21743475, ECO:0000269|PubMed:23129660, ECO:0000269|PubMed:24981174, ECO:0000269|PubMed:25179605, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27193484, ECO:0000269|PubMed:28104892}.; FUNCTION: Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity (PubMed:17403783). When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2) (PubMed:18765639). {ECO:0000269|PubMed:17403783, ECO:0000269|PubMed:18765639}.; FUNCTION: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC). {ECO:0000269|PubMed:18055229, ECO:0000269|PubMed:18852879}.; FUNCTION: Mediates ricin-induced apoptosis. {ECO:0000269|PubMed:14960581}. |
| P46821 | MAP1B | S614 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P55196 | AFDN | S1779 | ochoa | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}. |
| P55201 | BRPF1 | S238 | ochoa | Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140) | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:24065767, PubMed:27939640). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac) (PubMed:24065767). Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation (PubMed:27939640). Positively regulates the transcription of RUNX1 and RUNX2 (PubMed:18794358). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:27939640}. |
| P68363 | TUBA1B | T271 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| P68366 | TUBA4A | T271 | ochoa | Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P78559 | MAP1A | S1600 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| Q02952 | AKAP12 | S841 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q07157 | TJP1 | S927 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q08050 | FOXM1 | S451 | ochoa|psp | Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HFH-11) (HNF-3/fork-head homolog 11) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident) (Winged-helix factor from INS-1 cells) | Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation (PubMed:19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed:17101782). Promotes transcription of PHB2 (PubMed:33754036). {ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:20360045, ECO:0000269|PubMed:33754036}. |
| Q08050 | FOXM1 | S489 | ochoa|psp | Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HFH-11) (HNF-3/fork-head homolog 11) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident) (Winged-helix factor from INS-1 cells) | Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation (PubMed:19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed:17101782). Promotes transcription of PHB2 (PubMed:33754036). {ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:20360045, ECO:0000269|PubMed:33754036}. |
| Q12873 | CHD3 | S1601 | ochoa | Chromodomain-helicase-DNA-binding protein 3 (CHD-3) (EC 3.6.4.-) (ATP-dependent helicase CHD3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc finger helicase) (hZFH) | ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666, PubMed:30397230, PubMed:9804427). Involved in transcriptional repression as part of the NuRD complex (PubMed:27068747). Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity (PubMed:17626165). {ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:27068747, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:30397230, ECO:0000269|PubMed:9804427}. |
| Q12888 | TP53BP1 | S765 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12931 | TRAP1 | S568 | ochoa|psp | Heat shock protein 75 kDa, mitochondrial (HSP 75) (Heat shock protein family C member 5) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1) | Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. {ECO:0000269|PubMed:23525905, ECO:0000269|PubMed:23564345, ECO:0000269|PubMed:23747254}. |
| Q12955 | ANK3 | S4298 | ochoa | Ankyrin-3 (ANK-3) (Ankyrin-G) | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}. |
| Q13428 | TCOF1 | S777 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q14151 | SAFB2 | S343 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q14160 | SCRIB | S1486 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
| Q14807 | KIF22 | S412 | ochoa | Kinesin-like protein KIF22 (Kinesin-like DNA-binding protein) (Kinesin-like protein 4) | Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA (By similarity). Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells (PubMed:25743205). {ECO:0000250|UniProtKB:Q9I869, ECO:0000269|PubMed:25743205}. |
| Q14966 | ZNF638 | S1100 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q15022 | SUZ12 | S695 | ochoa | Polycomb protein SUZ12 (Chromatin precipitated E2F target 9 protein) (ChET 9 protein) (Joined to JAZF1 protein) (Suppressor of zeste 12 protein homolog) | Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:15231737, PubMed:15385962, PubMed:16618801, PubMed:17344414, PubMed:18285464, PubMed:28229514, PubMed:29499137, PubMed:31959557). The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (PubMed:12351676, PubMed:12435631, PubMed:15099518, PubMed:15225548, PubMed:15385962, PubMed:15684044, PubMed:16431907, PubMed:18086877, PubMed:18285464). Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A (PubMed:15231737, PubMed:16618801, PubMed:17200670, PubMed:31959557). {ECO:0000269|PubMed:12351676, ECO:0000269|PubMed:12435631, ECO:0000269|PubMed:15099518, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:15684044, ECO:0000269|PubMed:16431907, ECO:0000269|PubMed:16618801, ECO:0000269|PubMed:17200670, ECO:0000269|PubMed:17344414, ECO:0000269|PubMed:18086877, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:28229514, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}. |
| Q15049 | MLC1 | S357 | ochoa | Membrane protein MLC1 (Megalencephalic leukoencephalopathy with subcortical cysts protein 1) | Transmembrane protein mainly expressed in brain astrocytes that may play a role in transport across the blood-brain and brain-cerebrospinal fluid barriers (PubMed:22328087). Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx (PubMed:22328087). May function as regulatory protein of membrane protein complexes such as ion channels (Probable). {ECO:0000269|PubMed:22328087, ECO:0000305|PubMed:22328087}. |
| Q15424 | SAFB | S344 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q32MK0 | MYLK3 | S408 | ochoa | Myosin light chain kinase 3 (EC 2.7.11.18) (Cardiac-MyBP-C-associated Ca/CaM kinase) (Cardiac-MLCK) | Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity). {ECO:0000250}. |
| Q32MZ4 | LRRFIP1 | S638 | ochoa | Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}. |
| Q3KR37 | GRAMD1B | S581 | ochoa | Protein Aster-B (GRAM domain-containing protein 1B) | Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). {ECO:0000250|UniProtKB:Q80TI0}. |
| Q5JTC6 | AMER1 | S280 | ochoa | APC membrane recruitment protein 1 (Amer1) (Protein FAM123B) (Wilms tumor gene on the X chromosome protein) | Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development. {ECO:0000269|PubMed:17510365, ECO:0000269|PubMed:17925383, ECO:0000269|PubMed:19416806, ECO:0000269|PubMed:21304492, ECO:0000269|PubMed:21498506}. |
| Q5JVS0 | HABP4 | S273 | ochoa | Intracellular hyaluronan-binding protein 4 (IHABP-4) (IHABP4) (Hyaluronan-binding protein 4) (Ki-1/57 intracellular antigen) | Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (By similarity). Acts via its association with EEF2/eEF2 factor at the A-site of the ribosome, promoting ribosome stabilization in an inactive state compatible with storage (By similarity). Plays a key role in ribosome hibernation in the mature oocyte by promoting ribosome stabilization (By similarity). Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the oocyte and early embryo (By similarity). Also binds RNA, regulating transcription and pre-mRNA splicing (PubMed:14699138, PubMed:16455055, PubMed:19523114, PubMed:21771594). Binds (via C-terminus) to poly(U) RNA (PubMed:19523114). Seems to play a role in PML-nuclear bodies formation (PubMed:28695742). Negatively regulates DNA-binding activity of the transcription factor MEF2C in myocardial cells in response to mechanical stress (By similarity). {ECO:0000250|UniProtKB:A1L1K8, ECO:0000250|UniProtKB:Q5XJA5, ECO:0000269|PubMed:14699138, ECO:0000269|PubMed:16455055, ECO:0000269|PubMed:19523114, ECO:0000269|PubMed:21771594, ECO:0000269|PubMed:28695742}. |
| Q5T1V6 | DDX59 | S160 | ochoa | Probable ATP-dependent RNA helicase DDX59 (EC 3.6.4.13) (DEAD box protein 59) (Zinc finger HIT domain-containing protein 5) | None |
| Q6IQ55 | TTBK2 | S781 | ochoa | Tau-tubulin kinase 2 (EC 2.7.11.1) | Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro (PubMed:23141541). Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis (PubMed:30375385). Required for recruitment of CPLANE2 and INTU to the mother centriole (By similarity). {ECO:0000250|UniProtKB:Q3UVR3, ECO:0000269|PubMed:21548880, ECO:0000269|PubMed:23141541, ECO:0000269|PubMed:30375385}. |
| Q6JBY9 | RCSD1 | S68 | ochoa | CapZ-interacting protein (Protein kinase substrate CapZIP) (RCSD domain-containing protein 1) | Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly. {ECO:0000269|PubMed:15850461}. |
| Q6PEY2 | TUBA3E | T271 | ochoa | Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q6PJT7 | ZC3H14 | S274 | ochoa | Zinc finger CCCH domain-containing protein 14 (Mammalian suppressor of tau pathology-2) (MSUT-2) (Renal carcinoma antigen NY-REN-37) | RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs (PubMed:39461343). Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome (PubMed:39461343). Required for spermatogenesis via involvement in circRNA biogenesis (PubMed:39461343). Regulates the pre-mRNA processing of ATP5MC1; preventing its degradation (PubMed:27563065). Also binds the poly(A) tail of mRNAs; controlling poly(A) length in neuronal cells (PubMed:17630287, PubMed:24671764). {ECO:0000269|PubMed:17630287, ECO:0000269|PubMed:24671764, ECO:0000269|PubMed:27563065, ECO:0000269|PubMed:39461343}. |
| Q6ZRV2 | FAM83H | S1147 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q6ZUM4 | ARHGAP27 | S486 | ochoa | Rho GTPase-activating protein 27 (CIN85-associated multi-domain-containing Rho GTPase-activating protein 1) (Rho-type GTPase-activating protein 27) (SH3 domain-containing protein 20) | Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity). {ECO:0000250}. |
| Q6ZV73 | FGD6 | S1210 | ochoa | FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24) | May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}. |
| Q71U36 | TUBA1A | T271 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q7Z2Z1 | TICRR | S1334 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q7Z333 | SETX | S642 | ochoa | Probable helicase senataxin (EC 3.6.4.-) (Amyotrophic lateral sclerosis 4 protein) (SEN1 homolog) (Senataxin) | Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224, PubMed:26700805). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (By similarity). Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789). In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity). May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PubMed:21576111). {ECO:0000250|UniProtKB:A2AKX3, ECO:0000269|PubMed:17562789, ECO:0000269|PubMed:19515850, ECO:0000269|PubMed:21112256, ECO:0000269|PubMed:21576111, ECO:0000269|PubMed:21700224, ECO:0000269|PubMed:24105744, ECO:0000269|PubMed:26700805}. |
| Q7Z4V5 | HDGFL2 | S608 | ochoa | Hepatoma-derived growth factor-related protein 2 (HDGF-related protein 2) (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2) | Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350). Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (PubMed:26721387). Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (PubMed:26721387, PubMed:32459350). Involved in cellular growth control, through the regulation of cyclin D1 expression (PubMed:25689719). {ECO:0000269|PubMed:25689719, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:32459350}. |
| Q7Z7L8 | C11orf96 | S385 | ochoa | Uncharacterized protein C11orf96 (Protein Ag2 homolog) | None |
| Q8TD55 | PLEKHO2 | S278 | ochoa | Pleckstrin homology domain-containing family O member 2 (PH domain-containing family O member 2) (Pleckstrin homology domain-containing family Q member 1) (PH domain-containing family Q member 1) | None |
| Q8WUY3 | PRUNE2 | S2211 | ochoa | Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) | May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}. |
| Q8WV28 | BLNK | S197 | ochoa | B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65) | Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis. {ECO:0000269|PubMed:10583958, ECO:0000269|PubMed:15270728, ECO:0000269|PubMed:16912232, ECO:0000269|PubMed:9697839}. |
| Q8WV44 | TRIM41 | S401 | ochoa | E3 ubiquitin-protein ligase TRIM41 (EC 2.3.2.27) (RING finger-interacting protein with C kinase) (RINCK) (Tripartite motif-containing protein 41) | E3 ligase that plays essential roles in innate antiviral response (PubMed:28169297, PubMed:29760876, PubMed:29899090, PubMed:31979016). Directly binds to influenza A virus or vesicular stomatitis virus nucleoproteins and targets them for ubiquitination and proteasomal degradation, thereby limiting viral infections (PubMed:28169297, PubMed:29899090, PubMed:31979016). Activates the innate antiviral response by catalyzing monoubiquitination of CGAS, thereby activating CGAS (PubMed:29760876). Also involved in innate antiviral response by mediating 'Lys-63'-linked polyubiquitylation of BCL10 which in turn hubs NEMO for activation of NF-kappa-B and IRF3 pathways (By similarity). Catalyzes the ubiquitin-mediated degradation of other substrates including protein kinase C, ZSCAN21 or TOP3B suggesting additional roles besides its function in immune response (PubMed:17893151, PubMed:33378676). {ECO:0000250|UniProtKB:Q5NCC3, ECO:0000269|PubMed:17893151, ECO:0000269|PubMed:28169297, ECO:0000269|PubMed:29760876, ECO:0000269|PubMed:29899090, ECO:0000269|PubMed:31979016, ECO:0000269|PubMed:33378676}. |
| Q8WYP5 | AHCTF1 | S1087 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q92576 | PHF3 | S1063 | ochoa | PHD finger protein 3 | None |
| Q92628 | KIAA0232 | S164 | ochoa | Uncharacterized protein KIAA0232 | None |
| Q96BU1 | S100PBP | S201 | ochoa | S100P-binding protein (S100P-binding protein Riken) | None |
| Q96D09 | GPRASP2 | S542 | ochoa | G-protein coupled receptor-associated sorting protein 2 (GASP-2) | May play a role in regulation of a variety of G-protein coupled receptors. {ECO:0000269|PubMed:15086532}. |
| Q96EI5 | TCEAL4 | S108 | ochoa | Transcription elongation factor A protein-like 4 (TCEA-like protein 4) (Transcription elongation factor S-II protein-like 4) | May be involved in transcriptional regulation. |
| Q96JZ2 | HSH2D | S188 | ochoa | Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X) | May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity). Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter. {ECO:0000250, ECO:0000269|PubMed:11700021, ECO:0000269|PubMed:12960172, ECO:0000269|PubMed:15284240}. |
| Q96NA2 | RILP | S361 | ochoa | Rab-interacting lysosomal protein | Rab effector playing a role in late endocytic transport to degradative compartments (PubMed:11179213, PubMed:11696325, PubMed:12944476, PubMed:14668488, PubMed:27113757). Involved in the regulation of lysosomal morphology and distribution (PubMed:14668488, PubMed:27113757). Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments (PubMed:11179213, PubMed:11696325). Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes (PubMed:12944476). {ECO:0000269|PubMed:11179213, ECO:0000269|PubMed:11696325, ECO:0000269|PubMed:12944476, ECO:0000269|PubMed:14668488, ECO:0000269|PubMed:27113757}. |
| Q96NY7 | CLIC6 | S112 | ochoa | Chloride intracellular channel protein 6 (Glutaredoxin-like oxidoreductase CLIC6) (EC 1.8.-.-) (Parchorin) | In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (By similarity). Can insert into membranes and form voltage-dependent chloride-selective channels. The channel opens upon membrane depolarization at positive voltages and closes at negative membrane voltages (PubMed:37838179). May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity). {ECO:0000250|UniProtKB:Q9N2G5, ECO:0000250|UniProtKB:Q9Y696, ECO:0000269|PubMed:37838179}. |
| Q99958 | FOXC2 | S219 | ochoa|psp | Forkhead box protein C2 (Forkhead-related protein FKHL14) (Mesenchyme fork head protein 1) (MFH-1 protein) (Transcription factor FKH-14) | Transcriptional activator. {ECO:0000269|PubMed:9169153}. |
| Q9BQE3 | TUBA1C | T271 | ochoa | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9BSL1 | UBAC1 | S98 | ochoa | Ubiquitin-associated domain-containing protein 1 (UBA domain-containing protein 1) (Glialblastoma cell differentiation-related protein 1) (Kip1 ubiquitination-promoting complex protein 2) | Non-catalytic component of the KPC complex, a E3 ubiquitin-protein ligase complex that mediates polyubiquitination of target proteins, such as CDKN1B and NFKB1 (PubMed:15531880, PubMed:15746103, PubMed:16227581, PubMed:25860612). The KPC complex catalyzes polyubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle (PubMed:15531880, PubMed:15746103). The KPC complex also acts as a key regulator of the NF-kappa-B signaling by promoting maturation of the NFKB1 component of NF-kappa-B by catalyzing ubiquitination of the NFKB1 p105 precursor (PubMed:25860612). Within the KPC complex, UBAC1 acts as an adapter that promotes the transfer of target proteins that have been polyubiquitinated by RNF123/KPC1 to the 26S proteasome (PubMed:16227581). {ECO:0000269|PubMed:15531880, ECO:0000269|PubMed:15746103, ECO:0000269|PubMed:16227581, ECO:0000269|PubMed:25860612}. |
| Q9BW72 | HIGD2A | S25 | ochoa | HIG1 domain family member 2A, mitochondrial (RCF1 homolog B) (RCF1b) | Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May be involved in cytochrome c oxidase activity. May play a role in the assembly of respiratory supercomplexes. {ECO:0000269|PubMed:22342701}. |
| Q9BY89 | KIAA1671 | S404 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9BY89 | KIAA1671 | S1695 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9C073 | FAM117A | S355 | ochoa | Protein FAM117A (C/EBP-induced protein) | None |
| Q9C0C9 | UBE2O | S896 | ochoa | (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O) | E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). {ECO:0000269|PubMed:23381138, ECO:0000269|PubMed:23452853, ECO:0000269|PubMed:23455153, ECO:0000269|PubMed:24703950}. |
| Q9H171 | ZBP1 | S27 | ochoa | Z-DNA-binding protein 1 (DNA-dependent activator of IFN-regulatory factors) (DAI) (Tumor stroma and activated macrophage protein DLM-1) | Key innate sensor that recognizes and binds Z-RNA structures, which are produced by a number of viruses, such as herpesvirus, orthomyxovirus or flavivirus, and triggers different forms of cell death (PubMed:32200799). ZBP1 acts as an essential mediator of pyroptosis, necroptosis and apoptosis (PANoptosis), an integral part of host defense against pathogens, by activating RIPK3, caspase-8 (CASP8), and the NLRP3 inflammasome (By similarity). Key activator of necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members, via its ability to bind Z-RNA: once activated upon Z-RNA-binding, ZBP1 interacts and stimulates RIPK3 kinase, which phosphorylates and activates MLKL, triggering execution of programmed necrosis (By similarity). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: ZBP1 recognizes and binds Z-RNA structures that are produced in infected nuclei by orthomyxoviruses, such as the influenza A virus (IAV), leading to ZBP1 activation, RIPK3 stimulation and subsequent MLKL phosphorylation, triggering disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (PubMed:32200799). ZBP1-dependent cell death in response to IAV infection promotes interleukin-1 alpha (IL1A) induction in an NLRP3-inflammasome-independent manner: IL1A expression is required for the optimal interleukin-1 beta (IL1B) production, and together, these cytokines promote infiltration of inflammatory neutrophils to the lung, leading to the formation of neutrophil extracellular traps (By similarity). In addition to its direct role in driving necroptosis via its ability to sense Z-RNAs, also involved in PANoptosis triggered in response to bacterial infection: component of the AIM2 PANoptosome complex, a multiprotein complex that triggers PANoptosis (By similarity). Also acts as the apical sensor of fungal infection responsible for activating PANoptosis (By similarity). Involved in CASP8-mediated cell death via its interaction with RIPK1 but independently of its ability to sense Z-RNAs (By similarity). In some cell types, also able to restrict viral replication by promoting cell death-independent responses (By similarity). In response to Zika virus infection in neurons, promotes a cell death-independent pathway that restricts viral replication: together with RIPK3, promotes a death-independent transcriptional program that modifies the cellular metabolism via up-regulation expression of the enzyme ACOD1/IRG1 and production of the metabolite itaconate (By similarity). Itaconate inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity). {ECO:0000250|UniProtKB:Q9QY24, ECO:0000269|PubMed:32200799}.; FUNCTION: (Microbial infection) In case of herpes simplex virus 1/HHV-1 infection, forms hetero-amyloid structures with HHV-1 protein RIR1/ICP6 which may inhibit ZBP1-mediated necroptosis, thereby preventing host cell death pathway and allowing viral evasion. {ECO:0000269|PubMed:33348174}. |
| Q9H1V8 | SLC6A17 | S686 | ochoa | Sodium-dependent neutral amino acid transporter SLC6A17 (Sodium-dependent neurotransmitter transporter NTT4) (Solute carrier family 6 member 17) | Synaptic vesicle transporter with apparent selectivity for neutral amino acids. The transport is sodium-coupled but chloride-independent, likely driven by the proton electrochemical gradient generated by vacuolar H(+)-ATPase in an overall electrogenic mechanism. May contribute to the synaptic uptake of neurotransmitter precursors in a process coupled in part to vesicle exocytosis. {ECO:0000250|UniProtKB:P31662}. |
| Q9H6S3 | EPS8L2 | S449 | ochoa | Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2) | Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). {ECO:0000250|UniProtKB:Q99K30, ECO:0000269|PubMed:14565974}. |
| Q9NR48 | ASH1L | S1953 | ochoa | Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H) | Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). {ECO:0000250|UniProtKB:Q99MY8, ECO:0000269|PubMed:21239497}. |
| Q9NS68 | TNFRSF19 | S261 | ochoa | Tumor necrosis factor receptor superfamily member 19 (TRADE) (Toxicity and JNK inducer) | Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death. |
| Q9NSC5 | HOMER3 | S128 | ochoa | Homer protein homolog 3 (Homer-3) | Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901). {ECO:0000269|PubMed:18218901}. |
| Q9NZ63 | C9orf78 | S261 | ochoa | Splicing factor C9orf78 (Hepatocellular carcinoma-associated antigen 59) | Plays a role in pre-mRNA splicing by promoting usage of the upstream 3'-splice site at alternative NAGNAG splice sites; these are sites featuring alternative acceptor motifs separated by only a few nucleotides (PubMed:35241646). May also modulate exon inclusion events (PubMed:35241646). Plays a role in spliceosomal remodeling by displacing WBP4 from SNRNP200 and may act to inhibit SNRNP200 helicase activity (PubMed:35241646). Binds U5 snRNA (PubMed:35241646). Required for proper chromosome segregation (PubMed:35167828). Not required for splicing of shelterin components (PubMed:35167828). {ECO:0000269|PubMed:35167828, ECO:0000269|PubMed:35241646}. |
| Q9P266 | JCAD | S1194 | ochoa | Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) | None |
| Q9UD71 | PPP1R1B | S52 | ochoa | Protein phosphatase 1 regulatory subunit 1B (DARPP-32) (Dopamine- and cAMP-regulated neuronal phosphoprotein) | Inhibitor of protein-phosphatase 1. |
| Q9UKE5 | TNIK | S526 | ochoa | TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) | Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}. |
| Q9UKV3 | ACIN1 | S729 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9ULJ3 | ZBTB21 | S504 | ochoa | Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) | Acts as a transcription repressor. {ECO:0000269|PubMed:15629158}. |
| Q9UN86 | G3BP2 | S225 | ochoa | Ras GTPase-activating protein-binding protein 2 (G3BP-2) (GAP SH3 domain-binding protein 2) | Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling (PubMed:23279204, PubMed:32302570, PubMed:32302571, PubMed:32302572). Plays an essential role in stress granule formation (PubMed:27022092, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:35977029). Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress (PubMed:32302570, PubMed:32302571, PubMed:32302572). Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations (By similarity). {ECO:0000250|UniProtKB:Q13283, ECO:0000269|PubMed:23279204, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:32302571, ECO:0000269|PubMed:32302572, ECO:0000269|PubMed:35977029}. |
| Q9UPV0 | CEP164 | S380 | ochoa | Centrosomal protein of 164 kDa (Cep164) | Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. {ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:23348840}. |
| Q9UPV0 | CEP164 | S577 | ochoa | Centrosomal protein of 164 kDa (Cep164) | Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. {ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:23348840}. |
| Q9UPZ3 | HPS5 | S602 | ochoa | BLOC-2 complex member HPS5 (Alpha-integrin-binding protein 63) (Hermansky-Pudlak syndrome 5 protein) (Ruby-eye protein 2 homolog) (Ru2) | May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins. {ECO:0000269|PubMed:15296495, ECO:0000269|PubMed:17301833}. |
| Q9Y217 | MTMR6 | S589 | ochoa | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6 (EC 3.1.3.95) (Myotubularin-related protein 6) (Phosphatidylinositol-3-phosphate phosphatase) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate (PubMed:19038970, PubMed:22647598). Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) but also to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), phosphatidic acid and phosphatidylserine (PubMed:19038970). Negatively regulates ER-Golgi protein transport (By similarity). Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles (PubMed:24591580). Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4(+) T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate (PubMed:15831468). Negatively regulates proliferation of reactivated CD4(+) T-cells (PubMed:16847315). In complex with MTMR9, negatively regulates DNA damage-induced apoptosis (PubMed:19038970, PubMed:22647598). The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels (PubMed:19038970). {ECO:0000250|UniProtKB:A0A0G2JXT6, ECO:0000269|PubMed:15831468, ECO:0000269|PubMed:16847315, ECO:0000269|PubMed:19038970, ECO:0000269|PubMed:22647598, ECO:0000269|PubMed:24591580, ECO:0000305|PubMed:24591580}. |
| Q9Y2G0 | EFR3B | S214 | ochoa | Protein EFR3 homolog B | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:25608530, PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, EFR3B probably acts as the membrane-anchoring component (PubMed:23229899). Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect (PubMed:25380825). {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:25380825, ECO:0000269|PubMed:25608530, ECO:0000269|PubMed:26571211, ECO:0000305}. |
| Q9Y6M1 | IGF2BP2 | S149 | ochoa | Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2 mRNA-binding protein 2) (IMP-2) (Hepatocellular carcinoma autoantigen p62) (IGF-II mRNA-binding protein 2) (VICKZ family member 2) | RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed:29476152). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs (PubMed:9891060). Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (PubMed:29476152). {ECO:0000250, ECO:0000269|PubMed:23640942, ECO:0000269|PubMed:29476152, ECO:0000269|PubMed:9891060}. |
| Q9Y6R4 | MAP3K4 | S431 | ochoa | Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAP three kinase 1) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) | Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6. {ECO:0000269|PubMed:12052864, ECO:0000269|PubMed:9305639}. |
| Q14204 | DYNC1H1 | S2410 | Sugiyama | Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic) | Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074). {ECO:0000269|PubMed:27462074}. |
| O60674 | JAK2 | S1016 | Sugiyama | Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2) | Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin receptor (MPL/TPOR); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins (PubMed:15690087, PubMed:7615558, PubMed:9657743, PubMed:15899890). Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins (PubMed:15690087, PubMed:9618263). Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain (PubMed:9657743). Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B) (PubMed:21368206). In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation (PubMed:20098430). Plays a role in cell cycle by phosphorylating CDKN1B (PubMed:21423214). Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin (PubMed:19783980). Up-regulates the potassium voltage-gated channel activity of KCNA3 (PubMed:25644777). {ECO:0000269|PubMed:12023369, ECO:0000269|PubMed:15690087, ECO:0000269|PubMed:19783980, ECO:0000269|PubMed:20098430, ECO:0000269|PubMed:21368206, ECO:0000269|PubMed:21423214, ECO:0000269|PubMed:25644777, ECO:0000269|PubMed:7615558, ECO:0000269|PubMed:9618263, ECO:0000269|PubMed:9657743}. |
| P12036 | NEFH | S518 | SIGNOR|iPTMNet | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P19246}. |
| P29597 | TYK2 | S1063 | Sugiyama | Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2) | Tyrosine kinase of the non-receptor type involved in numerous cytokines and interferons signaling, which regulates cell growth, development, cell migration, innate and adaptive immunity (PubMed:10542297, PubMed:10995743, PubMed:7657660, PubMed:7813427, PubMed:8232552). Plays both structural and catalytic roles in numerous interleukins and interferons (IFN-alpha/beta) signaling (PubMed:10542297). Associates with heterodimeric cytokine receptor complexes and activates STAT family members including STAT1, STAT3, STAT4 or STAT6 (PubMed:10542297, PubMed:7638186). The heterodimeric cytokine receptor complexes are composed of (1) a TYK2-associated receptor chain (IFNAR1, IL12RB1, IL10RB or IL13RA1), and (2) a second receptor chain associated either with JAK1 or JAK2 (PubMed:10542297, PubMed:25762719, PubMed:7526154, PubMed:7813427). In response to cytokine-binding to receptors, phosphorylates and activates receptors (IFNAR1, IL12RB1, IL10RB or IL13RA1), creating docking sites for STAT members (PubMed:7526154, PubMed:7657660). In turn, recruited STATs are phosphorylated by TYK2 (or JAK1/JAK2 on the second receptor chain), form homo- and heterodimers, translocate to the nucleus, and regulate cytokine/growth factor responsive genes (PubMed:10542297, PubMed:25762719, PubMed:7657660). Negatively regulates STAT3 activity by promototing phosphorylation at a specific tyrosine that differs from the site used for signaling (PubMed:29162862). {ECO:0000269|PubMed:10542297, ECO:0000269|PubMed:10995743, ECO:0000269|PubMed:25762719, ECO:0000269|PubMed:29162862, ECO:0000269|PubMed:7526154, ECO:0000269|PubMed:7638186, ECO:0000269|PubMed:7657660, ECO:0000269|PubMed:7813427, ECO:0000269|PubMed:8232552}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 4.895099e-10 | 9.310 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 6.640641e-10 | 9.178 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 1.175765e-09 | 8.930 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 4.084648e-09 | 8.389 |
| R-HSA-9646399 | Aggrephagy | 3.535081e-09 | 8.452 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 4.872743e-09 | 8.312 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 9.570021e-09 | 8.019 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 1.697911e-08 | 7.770 |
| R-HSA-157858 | Gap junction trafficking and regulation | 1.554391e-08 | 7.808 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 2.424286e-08 | 7.615 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 3.334698e-08 | 7.477 |
| R-HSA-190861 | Gap junction assembly | 3.398193e-08 | 7.469 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 6.429240e-08 | 7.192 |
| R-HSA-69275 | G2/M Transition | 5.877236e-08 | 7.231 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 6.521165e-08 | 7.186 |
| R-HSA-983189 | Kinesins | 5.954990e-08 | 7.225 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 7.416271e-08 | 7.130 |
| R-HSA-2132295 | MHC class II antigen presentation | 1.065162e-07 | 6.973 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.460535e-07 | 6.835 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.379389e-07 | 6.860 |
| R-HSA-190828 | Gap junction trafficking | 1.675928e-07 | 6.776 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 1.845373e-07 | 6.734 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 2.436241e-07 | 6.613 |
| R-HSA-437239 | Recycling pathway of L1 | 2.436241e-07 | 6.613 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 4.046827e-07 | 6.393 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 4.136199e-07 | 6.383 |
| R-HSA-9833482 | PKR-mediated signaling | 4.136199e-07 | 6.383 |
| R-HSA-5617833 | Cilium Assembly | 6.064042e-07 | 6.217 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 7.893894e-07 | 6.103 |
| R-HSA-438064 | Post NMDA receptor activation events | 7.893894e-07 | 6.103 |
| R-HSA-373760 | L1CAM interactions | 7.296340e-07 | 6.137 |
| R-HSA-9663891 | Selective autophagy | 8.523017e-07 | 6.069 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 9.932243e-07 | 6.003 |
| R-HSA-391251 | Protein folding | 1.235129e-06 | 5.908 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.755800e-06 | 5.756 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 2.094685e-06 | 5.679 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 2.617146e-06 | 5.582 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 2.416071e-06 | 5.617 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 3.117863e-06 | 5.506 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 3.165069e-06 | 5.500 |
| R-HSA-5620924 | Intraflagellar transport | 4.828810e-06 | 5.316 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 5.011829e-06 | 5.300 |
| R-HSA-68877 | Mitotic Prometaphase | 5.241781e-06 | 5.281 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 6.942545e-06 | 5.158 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 6.972840e-06 | 5.157 |
| R-HSA-69278 | Cell Cycle, Mitotic | 9.143382e-06 | 5.039 |
| R-HSA-2467813 | Separation of Sister Chromatids | 1.089373e-05 | 4.963 |
| R-HSA-1632852 | Macroautophagy | 2.890898e-05 | 4.539 |
| R-HSA-1640170 | Cell Cycle | 3.438432e-05 | 4.464 |
| R-HSA-9609690 | HCMV Early Events | 3.972177e-05 | 4.401 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 4.901812e-05 | 4.310 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 5.630192e-05 | 4.249 |
| R-HSA-9612973 | Autophagy | 5.663005e-05 | 4.247 |
| R-HSA-913531 | Interferon Signaling | 5.785730e-05 | 4.238 |
| R-HSA-68882 | Mitotic Anaphase | 8.061287e-05 | 4.094 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 8.321918e-05 | 4.080 |
| R-HSA-112411 | MAPK1 (ERK2) activation | 1.115831e-04 | 3.952 |
| R-HSA-5610787 | Hedgehog 'off' state | 2.096164e-04 | 3.679 |
| R-HSA-9609646 | HCMV Infection | 2.189971e-04 | 3.660 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 2.305106e-04 | 3.637 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 3.031842e-04 | 3.518 |
| R-HSA-9700206 | Signaling by ALK in cancer | 3.031842e-04 | 3.518 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 3.948957e-04 | 3.404 |
| R-HSA-6804754 | Regulation of TP53 Expression | 4.392324e-04 | 3.357 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 8.989288e-04 | 3.046 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 9.672985e-04 | 3.014 |
| R-HSA-68886 | M Phase | 9.778105e-04 | 3.010 |
| R-HSA-5358351 | Signaling by Hedgehog | 1.190802e-03 | 2.924 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 1.298930e-03 | 2.886 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 1.722762e-03 | 2.764 |
| R-HSA-199991 | Membrane Trafficking | 1.629185e-03 | 2.788 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 1.824297e-03 | 2.739 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 2.131215e-03 | 2.671 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 2.131215e-03 | 2.671 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 2.464227e-03 | 2.608 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 2.472063e-03 | 2.607 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 3.409436e-03 | 2.467 |
| R-HSA-380287 | Centrosome maturation | 3.716133e-03 | 2.430 |
| R-HSA-9020933 | Interleukin-23 signaling | 3.209570e-03 | 2.494 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 3.306261e-03 | 2.481 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 3.484721e-03 | 2.458 |
| R-HSA-2559583 | Cellular Senescence | 4.091308e-03 | 2.388 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 4.439135e-03 | 2.353 |
| R-HSA-9020956 | Interleukin-27 signaling | 4.439135e-03 | 2.353 |
| R-HSA-110056 | MAPK3 (ERK1) activation | 4.439135e-03 | 2.353 |
| R-HSA-112315 | Transmission across Chemical Synapses | 4.544867e-03 | 2.342 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 5.328706e-03 | 2.273 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 5.409349e-03 | 2.267 |
| R-HSA-9824446 | Viral Infection Pathways | 5.573579e-03 | 2.254 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 5.852608e-03 | 2.233 |
| R-HSA-9723905 | Loss of function of TP53 in cancer due to loss of tetramerization ability | 7.486199e-03 | 2.126 |
| R-HSA-9723907 | Loss of Function of TP53 in Cancer | 7.486199e-03 | 2.126 |
| R-HSA-5467343 | Deletions in the AMER1 gene destabilize the destruction complex | 7.486199e-03 | 2.126 |
| R-HSA-8984722 | Interleukin-35 Signalling | 6.626532e-03 | 2.179 |
| R-HSA-1059683 | Interleukin-6 signaling | 7.444318e-03 | 2.128 |
| R-HSA-6788467 | IL-6-type cytokine receptor ligand interactions | 7.444318e-03 | 2.128 |
| R-HSA-877312 | Regulation of IFNG signaling | 6.626532e-03 | 2.179 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 6.445343e-03 | 2.191 |
| R-HSA-9679191 | Potential therapeutics for SARS | 9.063882e-03 | 2.043 |
| R-HSA-5653656 | Vesicle-mediated transport | 9.686862e-03 | 2.014 |
| R-HSA-2262752 | Cellular responses to stress | 1.138534e-02 | 1.944 |
| R-HSA-112316 | Neuronal System | 1.180212e-02 | 1.928 |
| R-HSA-3247509 | Chromatin modifying enzymes | 1.272593e-02 | 1.895 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.411515e-02 | 1.850 |
| R-HSA-1280218 | Adaptive Immune System | 1.422424e-02 | 1.847 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.441153e-02 | 1.841 |
| R-HSA-4839726 | Chromatin organization | 1.641940e-02 | 1.785 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 1.788671e-02 | 1.747 |
| R-HSA-109582 | Hemostasis | 1.833614e-02 | 1.737 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 1.914315e-02 | 1.718 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 1.914315e-02 | 1.718 |
| R-HSA-5693606 | DNA Double Strand Break Response | 1.936556e-02 | 1.713 |
| R-HSA-982772 | Growth hormone receptor signaling | 2.043568e-02 | 1.690 |
| R-HSA-8854691 | Interleukin-20 family signaling | 2.043568e-02 | 1.690 |
| R-HSA-6783589 | Interleukin-6 family signaling | 2.176369e-02 | 1.662 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 2.452380e-02 | 1.610 |
| R-HSA-4791275 | Signaling by WNT in cancer | 3.359534e-02 | 1.474 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 2.891547e-02 | 1.539 |
| R-HSA-6807070 | PTEN Regulation | 3.066917e-02 | 1.513 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.359534e-02 | 1.474 |
| R-HSA-422475 | Axon guidance | 2.739452e-02 | 1.562 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 3.521676e-02 | 1.453 |
| R-HSA-9645723 | Diseases of programmed cell death | 3.725519e-02 | 1.429 |
| R-HSA-5673000 | RAF activation | 3.854860e-02 | 1.414 |
| R-HSA-9675108 | Nervous system development | 3.860364e-02 | 1.413 |
| R-HSA-69205 | G1/S-Specific Transcription | 4.199559e-02 | 1.377 |
| R-HSA-162582 | Signal Transduction | 4.284602e-02 | 1.368 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 4.376097e-02 | 1.359 |
| R-HSA-9652169 | Signaling by MAP2K mutants | 4.409158e-02 | 1.356 |
| R-HSA-191650 | Regulation of gap junction activity | 4.409158e-02 | 1.356 |
| R-HSA-69895 | Transcriptional activation of cell cycle inhibitor p21 | 4.409158e-02 | 1.356 |
| R-HSA-69560 | Transcriptional activation of p53 responsive genes | 4.409158e-02 | 1.356 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 4.409158e-02 | 1.356 |
| R-HSA-111448 | Activation of NOXA and translocation to mitochondria | 4.409158e-02 | 1.356 |
| R-HSA-5633007 | Regulation of TP53 Activity | 4.596304e-02 | 1.338 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 4.737300e-02 | 1.324 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 5.109005e-02 | 1.292 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 5.109005e-02 | 1.292 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 5.109005e-02 | 1.292 |
| R-HSA-1606341 | IRF3 mediated activation of type 1 IFN | 5.125036e-02 | 1.290 |
| R-HSA-8849472 | PTK6 Down-Regulation | 5.125036e-02 | 1.290 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 5.125036e-02 | 1.290 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 5.298676e-02 | 1.276 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 5.490827e-02 | 1.260 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 6.540879e-02 | 1.184 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 7.240923e-02 | 1.140 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 6.283311e-02 | 1.202 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 6.283311e-02 | 1.202 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 6.283311e-02 | 1.202 |
| R-HSA-9710421 | Defective pyroptosis | 5.685413e-02 | 1.245 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 6.081700e-02 | 1.216 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 7.755174e-02 | 1.110 |
| R-HSA-6802949 | Signaling by RAS mutants | 6.283311e-02 | 1.202 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 7.240923e-02 | 1.140 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 5.835597e-02 | 1.234 |
| R-HSA-156584 | Cytosolic sulfonation of small molecules | 7.324255e-02 | 1.135 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 5.835597e-02 | 1.234 |
| R-HSA-168256 | Immune System | 6.275525e-02 | 1.202 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 8.500696e-02 | 1.071 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 7.935765e-02 | 1.100 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 8.416091e-02 | 1.075 |
| R-HSA-75153 | Apoptotic execution phase | 6.283311e-02 | 1.202 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 9.310002e-02 | 1.031 |
| R-HSA-68952 | DNA replication initiation | 9.310002e-02 | 1.031 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 9.989472e-02 | 1.000 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 9.989472e-02 | 1.000 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 9.989472e-02 | 1.000 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.066389e-01 | 0.972 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 1.133330e-01 | 0.946 |
| R-HSA-69091 | Polymerase switching | 1.133330e-01 | 0.946 |
| R-HSA-69109 | Leading Strand Synthesis | 1.133330e-01 | 0.946 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 1.133330e-01 | 0.946 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 1.133330e-01 | 0.946 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 1.133330e-01 | 0.946 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 1.133330e-01 | 0.946 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 1.133330e-01 | 0.946 |
| R-HSA-1170546 | Prolactin receptor signaling | 1.265723e-01 | 0.898 |
| R-HSA-69166 | Removal of the Flap Intermediate | 1.265723e-01 | 0.898 |
| R-HSA-9027284 | Erythropoietin activates RAS | 1.331183e-01 | 0.876 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 1.331183e-01 | 0.876 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 1.049356e-01 | 0.979 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.577061e-01 | 0.802 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.577061e-01 | 0.802 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 1.199774e-01 | 0.921 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 1.265723e-01 | 0.898 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 1.331183e-01 | 0.876 |
| R-HSA-156711 | Polo-like kinase mediated events | 1.588190e-01 | 0.799 |
| R-HSA-2586552 | Signaling by Leptin | 9.310002e-02 | 1.031 |
| R-HSA-174430 | Telomere C-strand synthesis initiation | 1.331183e-01 | 0.876 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 1.396156e-01 | 0.855 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 1.713846e-01 | 0.766 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 1.588190e-01 | 0.799 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 1.550879e-01 | 0.809 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 1.588190e-01 | 0.799 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 8.640111e-02 | 1.063 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 1.170173e-01 | 0.932 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 1.460645e-01 | 0.835 |
| R-HSA-4839744 | Signaling by APC mutants | 9.989472e-02 | 1.000 |
| R-HSA-4839735 | Signaling by AXIN mutants | 1.066389e-01 | 0.972 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.199774e-01 | 0.921 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 1.331183e-01 | 0.876 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 1.396156e-01 | 0.855 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 1.588190e-01 | 0.799 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 1.713846e-01 | 0.766 |
| R-HSA-447115 | Interleukin-12 family signaling | 1.629676e-01 | 0.788 |
| R-HSA-9761174 | Formation of intermediate mesoderm | 9.310002e-02 | 1.031 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 1.066389e-01 | 0.972 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.269227e-01 | 0.896 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.577654e-01 | 0.802 |
| R-HSA-170968 | Frs2-mediated activation | 1.199774e-01 | 0.921 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 1.199774e-01 | 0.921 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 1.651253e-01 | 0.782 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 1.170173e-01 | 0.932 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 1.460645e-01 | 0.835 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.385510e-01 | 0.858 |
| R-HSA-169893 | Prolonged ERK activation events | 1.396156e-01 | 0.855 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 1.219449e-01 | 0.914 |
| R-HSA-9020591 | Interleukin-12 signaling | 1.319482e-01 | 0.880 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 1.396156e-01 | 0.855 |
| R-HSA-5683057 | MAPK family signaling cascades | 1.435878e-01 | 0.843 |
| R-HSA-4086400 | PCP/CE pathway | 1.370190e-01 | 0.863 |
| R-HSA-912631 | Regulation of signaling by CBL | 1.651253e-01 | 0.782 |
| R-HSA-445144 | Signal transduction by L1 | 1.713846e-01 | 0.766 |
| R-HSA-6807004 | Negative regulation of MET activity | 1.713846e-01 | 0.766 |
| R-HSA-449836 | Other interleukin signaling | 1.651253e-01 | 0.782 |
| R-HSA-597592 | Post-translational protein modification | 1.263490e-01 | 0.898 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 1.524656e-01 | 0.817 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 1.267207e-01 | 0.897 |
| R-HSA-109581 | Apoptosis | 1.542874e-01 | 0.812 |
| R-HSA-1643685 | Disease | 1.162191e-01 | 0.935 |
| R-HSA-2028269 | Signaling by Hippo | 1.524656e-01 | 0.817 |
| R-HSA-9679506 | SARS-CoV Infections | 1.438788e-01 | 0.842 |
| R-HSA-5663205 | Infectious disease | 9.000728e-02 | 1.046 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 1.735828e-01 | 0.760 |
| R-HSA-69186 | Lagging Strand Synthesis | 1.775974e-01 | 0.751 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 1.775974e-01 | 0.751 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 1.837640e-01 | 0.736 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 1.837640e-01 | 0.736 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 1.837640e-01 | 0.736 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 1.898847e-01 | 0.722 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 1.898847e-01 | 0.722 |
| R-HSA-9669938 | Signaling by KIT in disease | 1.898847e-01 | 0.722 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 1.951261e-01 | 0.710 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 1.959599e-01 | 0.708 |
| R-HSA-9830674 | Formation of the ureteric bud | 1.959599e-01 | 0.708 |
| R-HSA-429947 | Deadenylation of mRNA | 2.019899e-01 | 0.695 |
| R-HSA-5669034 | TNFs bind their physiological receptors | 2.019899e-01 | 0.695 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 2.032928e-01 | 0.692 |
| R-HSA-9620244 | Long-term potentiation | 2.079751e-01 | 0.682 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 2.079751e-01 | 0.682 |
| R-HSA-3214842 | HDMs demethylate histones | 2.079751e-01 | 0.682 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 2.130880e-01 | 0.671 |
| R-HSA-449147 | Signaling by Interleukins | 2.134378e-01 | 0.671 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 2.139158e-01 | 0.670 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 2.146554e-01 | 0.668 |
| R-HSA-9833110 | RSV-host interactions | 2.169867e-01 | 0.664 |
| R-HSA-195721 | Signaling by WNT | 2.178000e-01 | 0.662 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 2.198122e-01 | 0.658 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 2.198122e-01 | 0.658 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 2.198122e-01 | 0.658 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 2.198122e-01 | 0.658 |
| R-HSA-77387 | Insulin receptor recycling | 2.256648e-01 | 0.647 |
| R-HSA-5620971 | Pyroptosis | 2.256648e-01 | 0.647 |
| R-HSA-9006335 | Signaling by Erythropoietin | 2.314739e-01 | 0.635 |
| R-HSA-180024 | DARPP-32 events | 2.314739e-01 | 0.635 |
| R-HSA-114452 | Activation of BH3-only proteins | 2.372397e-01 | 0.625 |
| R-HSA-68962 | Activation of the pre-replicative complex | 2.372397e-01 | 0.625 |
| R-HSA-5357801 | Programmed Cell Death | 2.397375e-01 | 0.620 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 2.429626e-01 | 0.614 |
| R-HSA-69190 | DNA strand elongation | 2.486429e-01 | 0.604 |
| R-HSA-909733 | Interferon alpha/beta signaling | 2.529098e-01 | 0.597 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 2.542810e-01 | 0.595 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 2.542810e-01 | 0.595 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 2.542810e-01 | 0.595 |
| R-HSA-354192 | Integrin signaling | 2.542810e-01 | 0.595 |
| R-HSA-390522 | Striated Muscle Contraction | 2.598771e-01 | 0.585 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 2.598771e-01 | 0.585 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 2.598771e-01 | 0.585 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 2.654316e-01 | 0.576 |
| R-HSA-418990 | Adherens junctions interactions | 2.658361e-01 | 0.575 |
| R-HSA-2559585 | Oncogene Induced Senescence | 2.709447e-01 | 0.567 |
| R-HSA-187687 | Signalling to ERKs | 2.709447e-01 | 0.567 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 2.709447e-01 | 0.567 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 2.709447e-01 | 0.567 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 2.764167e-01 | 0.558 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 2.764167e-01 | 0.558 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 2.818481e-01 | 0.550 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 2.818481e-01 | 0.550 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 2.820710e-01 | 0.550 |
| R-HSA-69206 | G1/S Transition | 2.834357e-01 | 0.548 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 2.861451e-01 | 0.543 |
| R-HSA-69481 | G2/M Checkpoints | 2.889804e-01 | 0.539 |
| R-HSA-114608 | Platelet degranulation | 2.889804e-01 | 0.539 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 2.896297e-01 | 0.538 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 2.917511e-01 | 0.535 |
| R-HSA-69541 | Stabilization of p53 | 2.925898e-01 | 0.534 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 2.925898e-01 | 0.534 |
| R-HSA-212436 | Generic Transcription Pathway | 2.930342e-01 | 0.533 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 2.979007e-01 | 0.526 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 2.979007e-01 | 0.526 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 2.979007e-01 | 0.526 |
| R-HSA-451927 | Interleukin-2 family signaling | 2.979007e-01 | 0.526 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 3.024569e-01 | 0.519 |
| R-HSA-9843745 | Adipogenesis | 3.028198e-01 | 0.519 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 3.083438e-01 | 0.511 |
| R-HSA-5674135 | MAP2K and MAPK activation | 3.084042e-01 | 0.511 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 3.084042e-01 | 0.511 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 3.084042e-01 | 0.511 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 3.084042e-01 | 0.511 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 3.135974e-01 | 0.504 |
| R-HSA-1433557 | Signaling by SCF-KIT | 3.187519e-01 | 0.497 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 3.193660e-01 | 0.496 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 3.193660e-01 | 0.496 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 3.221155e-01 | 0.492 |
| R-HSA-69236 | G1 Phase | 3.238680e-01 | 0.490 |
| R-HSA-69231 | Cyclin D associated events in G1 | 3.238680e-01 | 0.490 |
| R-HSA-3214858 | RMTs methylate histone arginines | 3.238680e-01 | 0.490 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 3.289460e-01 | 0.483 |
| R-HSA-421270 | Cell-cell junction organization | 3.332330e-01 | 0.477 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 3.385528e-01 | 0.470 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 3.389887e-01 | 0.470 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 3.389887e-01 | 0.470 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 3.412813e-01 | 0.467 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 3.439541e-01 | 0.463 |
| R-HSA-9031628 | NGF-stimulated transcription | 3.439541e-01 | 0.463 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 3.488825e-01 | 0.457 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 3.488825e-01 | 0.457 |
| R-HSA-166520 | Signaling by NTRKs | 3.548709e-01 | 0.450 |
| R-HSA-9864848 | Complex IV assembly | 3.586293e-01 | 0.445 |
| R-HSA-6794361 | Neurexins and neuroligins | 3.634483e-01 | 0.440 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 3.634483e-01 | 0.440 |
| R-HSA-3214815 | HDACs deacetylate histones | 3.776910e-01 | 0.423 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 3.802514e-01 | 0.420 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 3.823679e-01 | 0.418 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 3.823679e-01 | 0.418 |
| R-HSA-877300 | Interferon gamma signaling | 3.844085e-01 | 0.415 |
| R-HSA-9006936 | Signaling by TGFB family members | 3.870663e-01 | 0.412 |
| R-HSA-446728 | Cell junction organization | 3.883728e-01 | 0.411 |
| R-HSA-180786 | Extension of Telomeres | 3.961907e-01 | 0.402 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 3.961907e-01 | 0.402 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 3.964698e-01 | 0.402 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 4.007297e-01 | 0.397 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 4.007297e-01 | 0.397 |
| R-HSA-1266738 | Developmental Biology | 4.085760e-01 | 0.389 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 4.097066e-01 | 0.388 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 4.097066e-01 | 0.388 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 4.105721e-01 | 0.387 |
| R-HSA-73857 | RNA Polymerase II Transcription | 4.136663e-01 | 0.383 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 4.141448e-01 | 0.383 |
| R-HSA-8848021 | Signaling by PTK6 | 4.141448e-01 | 0.383 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 4.141448e-01 | 0.383 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 4.237257e-01 | 0.373 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 4.237257e-01 | 0.373 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 4.272621e-01 | 0.369 |
| R-HSA-9830369 | Kidney development | 4.315694e-01 | 0.365 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 4.358446e-01 | 0.361 |
| R-HSA-5218859 | Regulated Necrosis | 4.358446e-01 | 0.361 |
| R-HSA-611105 | Respiratory electron transport | 4.365491e-01 | 0.360 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 4.442996e-01 | 0.352 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 4.442996e-01 | 0.352 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 4.484799e-01 | 0.348 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 4.526290e-01 | 0.344 |
| R-HSA-1226099 | Signaling by FGFR in disease | 4.608345e-01 | 0.336 |
| R-HSA-1500931 | Cell-Cell communication | 4.639297e-01 | 0.334 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 4.648913e-01 | 0.333 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 4.648913e-01 | 0.333 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 4.648913e-01 | 0.333 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 4.689180e-01 | 0.329 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 4.765246e-01 | 0.322 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 4.768812e-01 | 0.322 |
| R-HSA-6783783 | Interleukin-10 signaling | 4.768812e-01 | 0.322 |
| R-HSA-73864 | RNA Polymerase I Transcription | 4.768812e-01 | 0.322 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 4.774360e-01 | 0.321 |
| R-HSA-9659379 | Sensory processing of sound | 4.808184e-01 | 0.318 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 4.814019e-01 | 0.317 |
| R-HSA-6806834 | Signaling by MET | 4.847261e-01 | 0.315 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 4.886046e-01 | 0.311 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 4.962751e-01 | 0.304 |
| R-HSA-72172 | mRNA Splicing | 5.030043e-01 | 0.298 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 5.038315e-01 | 0.298 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 5.038315e-01 | 0.298 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 5.112754e-01 | 0.291 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 5.261690e-01 | 0.279 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 5.294042e-01 | 0.276 |
| R-HSA-74160 | Gene expression (Transcription) | 5.360554e-01 | 0.271 |
| R-HSA-74752 | Signaling by Insulin receptor | 5.364675e-01 | 0.270 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 5.399596e-01 | 0.268 |
| R-HSA-73894 | DNA Repair | 5.460362e-01 | 0.263 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 5.536691e-01 | 0.257 |
| R-HSA-157579 | Telomere Maintenance | 5.570327e-01 | 0.254 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 5.570327e-01 | 0.254 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 5.603712e-01 | 0.252 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 5.603712e-01 | 0.252 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 5.603712e-01 | 0.252 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 5.603712e-01 | 0.252 |
| R-HSA-3214847 | HATs acetylate histones | 5.636847e-01 | 0.249 |
| R-HSA-9020702 | Interleukin-1 signaling | 5.702375e-01 | 0.244 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 5.734773e-01 | 0.241 |
| R-HSA-1483255 | PI Metabolism | 5.734773e-01 | 0.241 |
| R-HSA-8939211 | ESR-mediated signaling | 5.771298e-01 | 0.239 |
| R-HSA-111885 | Opioid Signalling | 5.798843e-01 | 0.237 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 5.798843e-01 | 0.237 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 5.798843e-01 | 0.237 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 5.813572e-01 | 0.236 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 5.830519e-01 | 0.234 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 5.830519e-01 | 0.234 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 5.861958e-01 | 0.232 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 5.876768e-01 | 0.231 |
| R-HSA-69239 | Synthesis of DNA | 5.924133e-01 | 0.227 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 5.954872e-01 | 0.225 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 5.985381e-01 | 0.223 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 5.985381e-01 | 0.223 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 6.015662e-01 | 0.221 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 6.015662e-01 | 0.221 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 6.105152e-01 | 0.214 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6.105152e-01 | 0.214 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 6.134537e-01 | 0.212 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 6.134537e-01 | 0.212 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 6.163702e-01 | 0.210 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 6.192649e-01 | 0.208 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 6.192649e-01 | 0.208 |
| R-HSA-5693538 | Homology Directed Repair | 6.306285e-01 | 0.200 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 6.334165e-01 | 0.198 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 6.334165e-01 | 0.198 |
| R-HSA-73886 | Chromosome Maintenance | 6.389300e-01 | 0.195 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 6.416558e-01 | 0.193 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 6.416558e-01 | 0.193 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 6.594492e-01 | 0.181 |
| R-HSA-392499 | Metabolism of proteins | 6.636535e-01 | 0.178 |
| R-HSA-6798695 | Neutrophil degranulation | 7.000493e-01 | 0.155 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 7.057113e-01 | 0.151 |
| R-HSA-69242 | S Phase | 7.145873e-01 | 0.146 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 7.145873e-01 | 0.146 |
| R-HSA-9758941 | Gastrulation | 7.167461e-01 | 0.145 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 7.210153e-01 | 0.142 |
| R-HSA-446652 | Interleukin-1 family signaling | 7.231259e-01 | 0.141 |
| R-HSA-69306 | DNA Replication | 7.252207e-01 | 0.140 |
| R-HSA-9609507 | Protein localization | 7.252207e-01 | 0.140 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 7.272997e-01 | 0.138 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 7.354610e-01 | 0.133 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 7.571033e-01 | 0.121 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 7.639656e-01 | 0.117 |
| R-HSA-5689880 | Ub-specific processing proteases | 7.657538e-01 | 0.116 |
| R-HSA-8953854 | Metabolism of RNA | 7.762343e-01 | 0.110 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 7.829124e-01 | 0.106 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 7.855057e-01 | 0.105 |
| R-HSA-168898 | Toll-like Receptor Cascades | 7.957369e-01 | 0.099 |
| R-HSA-389948 | Co-inhibition by PD-1 | 8.092681e-01 | 0.092 |
| R-HSA-397014 | Muscle contraction | 8.272582e-01 | 0.082 |
| R-HSA-8951664 | Neddylation | 8.387167e-01 | 0.076 |
| R-HSA-157118 | Signaling by NOTCH | 8.604897e-01 | 0.065 |
| R-HSA-5688426 | Deubiquitination | 8.755975e-01 | 0.058 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 8.765449e-01 | 0.057 |
| R-HSA-9711123 | Cellular response to chemical stress | 8.873709e-01 | 0.052 |
| R-HSA-1483257 | Phospholipid metabolism | 9.084076e-01 | 0.042 |
| R-HSA-211859 | Biological oxidations | 9.182263e-01 | 0.037 |
| R-HSA-168249 | Innate Immune System | 9.457767e-01 | 0.024 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.562123e-01 | 0.019 |
| R-HSA-418594 | G alpha (i) signalling events | 9.615947e-01 | 0.017 |
| R-HSA-388396 | GPCR downstream signalling | 9.978152e-01 | 0.001 |
| R-HSA-372790 | Signaling by GPCR | 9.988684e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999469e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999932e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
KIS |
0.779 | 0.609 | 1 | 0.818 |
CDK3 |
0.769 | 0.562 | 1 | 0.904 |
P38G |
0.767 | 0.632 | 1 | 0.909 |
CDK19 |
0.766 | 0.590 | 1 | 0.858 |
HIPK2 |
0.765 | 0.555 | 1 | 0.836 |
CDK18 |
0.764 | 0.588 | 1 | 0.875 |
CDK1 |
0.763 | 0.597 | 1 | 0.883 |
CDK17 |
0.763 | 0.601 | 1 | 0.909 |
CDK8 |
0.761 | 0.591 | 1 | 0.839 |
JNK2 |
0.761 | 0.630 | 1 | 0.884 |
P38D |
0.760 | 0.621 | 1 | 0.879 |
CLK3 |
0.758 | 0.435 | 1 | 0.615 |
CDK5 |
0.754 | 0.567 | 1 | 0.823 |
CDK16 |
0.753 | 0.568 | 1 | 0.901 |
ERK1 |
0.753 | 0.589 | 1 | 0.849 |
JNK3 |
0.752 | 0.618 | 1 | 0.869 |
CDK7 |
0.749 | 0.545 | 1 | 0.846 |
P38B |
0.749 | 0.581 | 1 | 0.851 |
DYRK2 |
0.749 | 0.526 | 1 | 0.786 |
CDK13 |
0.748 | 0.564 | 1 | 0.861 |
DYRK4 |
0.743 | 0.531 | 1 | 0.863 |
HIPK4 |
0.743 | 0.374 | 1 | 0.594 |
CDK12 |
0.742 | 0.555 | 1 | 0.875 |
JNK1 |
0.742 | 0.563 | 1 | 0.907 |
HIPK1 |
0.741 | 0.479 | 1 | 0.767 |
P38A |
0.740 | 0.568 | 1 | 0.783 |
CLK2 |
0.739 | 0.301 | -3 | 0.355 |
DYRK1B |
0.739 | 0.503 | 1 | 0.831 |
CLK1 |
0.737 | 0.310 | -3 | 0.334 |
SRPK1 |
0.735 | 0.232 | -3 | 0.322 |
CDK9 |
0.733 | 0.536 | 1 | 0.852 |
CDK14 |
0.733 | 0.526 | 1 | 0.853 |
DYRK1A |
0.732 | 0.410 | 1 | 0.763 |
CDK2 |
0.732 | 0.460 | 1 | 0.812 |
ERK2 |
0.732 | 0.565 | 1 | 0.819 |
HIPK3 |
0.728 | 0.458 | 1 | 0.731 |
CLK4 |
0.728 | 0.264 | -3 | 0.333 |
SRPK2 |
0.726 | 0.179 | -3 | 0.288 |
CDK10 |
0.726 | 0.484 | 1 | 0.860 |
NLK |
0.725 | 0.450 | 1 | 0.642 |
CDK6 |
0.723 | 0.519 | 1 | 0.851 |
CDK4 |
0.723 | 0.528 | 1 | 0.884 |
ERK5 |
0.718 | 0.256 | 1 | 0.535 |
COT |
0.717 | 0.041 | 2 | 0.767 |
MAK |
0.717 | 0.316 | -2 | 0.580 |
MTOR |
0.717 | 0.172 | 1 | 0.458 |
PRP4 |
0.714 | 0.306 | -3 | 0.280 |
DYRK3 |
0.714 | 0.342 | 1 | 0.728 |
SRPK3 |
0.712 | 0.140 | -3 | 0.300 |
ICK |
0.710 | 0.201 | -3 | 0.358 |
MOS |
0.710 | 0.038 | 1 | 0.369 |
CDC7 |
0.708 | -0.038 | 1 | 0.337 |
GRK7 |
0.708 | 0.091 | 1 | 0.382 |
CDKL1 |
0.707 | 0.057 | -3 | 0.338 |
PRPK |
0.706 | 0.007 | -1 | 0.780 |
CDKL5 |
0.706 | 0.067 | -3 | 0.329 |
CHAK2 |
0.706 | 0.051 | -1 | 0.837 |
BMPR1B |
0.705 | 0.082 | 1 | 0.309 |
TBK1 |
0.704 | -0.049 | 1 | 0.261 |
NDR2 |
0.702 | -0.013 | -3 | 0.401 |
IKKA |
0.702 | 0.027 | -2 | 0.597 |
TGFBR1 |
0.701 | 0.080 | -2 | 0.728 |
PRKD1 |
0.700 | 0.008 | -3 | 0.366 |
DSTYK |
0.699 | -0.073 | 2 | 0.771 |
GRK1 |
0.698 | 0.002 | -2 | 0.597 |
BMPR2 |
0.698 | -0.033 | -2 | 0.727 |
ALK4 |
0.697 | 0.067 | -2 | 0.744 |
TGFBR2 |
0.697 | -0.016 | -2 | 0.691 |
SKMLCK |
0.697 | -0.028 | -2 | 0.686 |
LATS1 |
0.697 | 0.036 | -3 | 0.416 |
IKKE |
0.697 | -0.085 | 1 | 0.260 |
MOK |
0.697 | 0.272 | 1 | 0.645 |
GCN2 |
0.696 | -0.047 | 2 | 0.691 |
RSK2 |
0.696 | -0.039 | -3 | 0.355 |
PIM3 |
0.696 | -0.054 | -3 | 0.393 |
LATS2 |
0.695 | -0.022 | -5 | 0.758 |
MAPKAPK2 |
0.695 | -0.026 | -3 | 0.344 |
NEK6 |
0.695 | -0.057 | -2 | 0.741 |
ATR |
0.695 | -0.047 | 1 | 0.332 |
NUAK2 |
0.693 | -0.025 | -3 | 0.378 |
IKKB |
0.693 | -0.106 | -2 | 0.584 |
PRKD2 |
0.693 | -0.011 | -3 | 0.359 |
PKN3 |
0.693 | -0.062 | -3 | 0.354 |
CAMK1B |
0.693 | -0.076 | -3 | 0.373 |
ACVR2B |
0.692 | 0.036 | -2 | 0.701 |
P90RSK |
0.692 | -0.044 | -3 | 0.346 |
PDHK4 |
0.692 | -0.179 | 1 | 0.362 |
WNK1 |
0.691 | -0.076 | -2 | 0.718 |
CAMK2G |
0.691 | -0.076 | 2 | 0.703 |
RAF1 |
0.690 | -0.171 | 1 | 0.299 |
ACVR2A |
0.690 | 0.032 | -2 | 0.690 |
RSK3 |
0.690 | -0.052 | -3 | 0.364 |
ULK2 |
0.690 | -0.161 | 2 | 0.703 |
MARK4 |
0.689 | -0.050 | 4 | 0.744 |
ERK7 |
0.689 | 0.173 | 2 | 0.455 |
PIM1 |
0.689 | -0.020 | -3 | 0.351 |
GRK5 |
0.689 | -0.100 | -3 | 0.355 |
NIK |
0.689 | -0.090 | -3 | 0.379 |
MAPKAPK3 |
0.688 | -0.071 | -3 | 0.337 |
NDR1 |
0.688 | -0.075 | -3 | 0.378 |
BMPR1A |
0.688 | 0.079 | 1 | 0.304 |
MST4 |
0.687 | -0.065 | 2 | 0.724 |
GRK6 |
0.687 | -0.049 | 1 | 0.348 |
CAMLCK |
0.686 | -0.072 | -2 | 0.643 |
TSSK1 |
0.686 | -0.031 | -3 | 0.398 |
ULK1 |
0.686 | -0.131 | -3 | 0.299 |
ALK2 |
0.686 | 0.041 | -2 | 0.716 |
PKCD |
0.685 | -0.047 | 2 | 0.672 |
AMPKA1 |
0.685 | -0.083 | -3 | 0.375 |
GSK3A |
0.685 | 0.144 | 4 | 0.417 |
PDHK1 |
0.685 | -0.189 | 1 | 0.333 |
NEK7 |
0.685 | -0.154 | -3 | 0.316 |
PLK2 |
0.685 | 0.244 | -3 | 0.662 |
HUNK |
0.684 | -0.112 | 2 | 0.741 |
DAPK2 |
0.684 | -0.099 | -3 | 0.365 |
AURC |
0.684 | -0.031 | -2 | 0.436 |
CAMK2D |
0.684 | -0.102 | -3 | 0.337 |
GRK4 |
0.682 | -0.064 | -2 | 0.665 |
PLK3 |
0.682 | 0.077 | 2 | 0.667 |
RSK4 |
0.682 | -0.038 | -3 | 0.357 |
MLK3 |
0.682 | -0.029 | 2 | 0.627 |
NUAK1 |
0.682 | -0.051 | -3 | 0.360 |
NIM1 |
0.682 | -0.073 | 3 | 0.664 |
TLK2 |
0.682 | -0.001 | 1 | 0.259 |
ATM |
0.681 | -0.032 | 1 | 0.294 |
P70S6KB |
0.681 | -0.074 | -3 | 0.342 |
FAM20C |
0.681 | 0.050 | 2 | 0.617 |
AMPKA2 |
0.681 | -0.074 | -3 | 0.365 |
DCAMKL1 |
0.681 | -0.033 | -3 | 0.377 |
MLK1 |
0.681 | -0.116 | 2 | 0.699 |
CK1E |
0.680 | -0.047 | -3 | 0.206 |
MNK2 |
0.680 | -0.049 | -2 | 0.583 |
TSSK2 |
0.680 | -0.066 | -5 | 0.764 |
GRK2 |
0.679 | -0.023 | -2 | 0.569 |
PKN2 |
0.678 | -0.123 | -3 | 0.338 |
PRKD3 |
0.678 | -0.050 | -3 | 0.332 |
MASTL |
0.678 | -0.190 | -2 | 0.643 |
CAMK2B |
0.678 | -0.055 | 2 | 0.670 |
PAK6 |
0.678 | -0.023 | -2 | 0.484 |
TTBK2 |
0.678 | -0.128 | 2 | 0.651 |
CAMK2A |
0.678 | -0.048 | 2 | 0.661 |
PKACB |
0.677 | -0.041 | -2 | 0.449 |
PKACG |
0.677 | -0.085 | -2 | 0.500 |
VRK2 |
0.677 | -0.023 | 1 | 0.377 |
SGK3 |
0.677 | -0.055 | -3 | 0.321 |
AKT2 |
0.677 | -0.039 | -3 | 0.301 |
QSK |
0.677 | -0.052 | 4 | 0.719 |
MNK1 |
0.677 | -0.048 | -2 | 0.585 |
PKR |
0.676 | -0.044 | 1 | 0.279 |
RIPK3 |
0.676 | -0.177 | 3 | 0.620 |
NEK9 |
0.676 | -0.174 | 2 | 0.743 |
PKCB |
0.676 | -0.059 | 2 | 0.631 |
MPSK1 |
0.676 | 0.014 | 1 | 0.283 |
IRE1 |
0.676 | -0.099 | 1 | 0.226 |
PRKX |
0.676 | -0.025 | -3 | 0.330 |
WNK3 |
0.676 | -0.209 | 1 | 0.269 |
PLK1 |
0.676 | -0.086 | -2 | 0.659 |
SIK |
0.675 | -0.060 | -3 | 0.333 |
PINK1 |
0.675 | 0.087 | 1 | 0.445 |
DNAPK |
0.675 | -0.044 | 1 | 0.291 |
MLK2 |
0.675 | -0.134 | 2 | 0.712 |
PHKG1 |
0.675 | -0.094 | -3 | 0.359 |
CHK1 |
0.675 | -0.036 | -3 | 0.433 |
YSK4 |
0.674 | -0.115 | 1 | 0.268 |
DLK |
0.674 | -0.205 | 1 | 0.321 |
PAK1 |
0.674 | -0.085 | -2 | 0.564 |
MELK |
0.674 | -0.105 | -3 | 0.343 |
MEK1 |
0.673 | -0.115 | 2 | 0.737 |
MARK3 |
0.673 | -0.044 | 4 | 0.675 |
MLK4 |
0.673 | -0.034 | 2 | 0.611 |
CHAK1 |
0.672 | -0.086 | 2 | 0.682 |
MSK2 |
0.672 | -0.093 | -3 | 0.309 |
ANKRD3 |
0.672 | -0.180 | 1 | 0.295 |
PKCA |
0.672 | -0.070 | 2 | 0.620 |
CK1D |
0.671 | -0.052 | -3 | 0.153 |
BCKDK |
0.671 | -0.174 | -1 | 0.651 |
SMG1 |
0.671 | -0.077 | 1 | 0.297 |
PASK |
0.670 | -0.018 | -3 | 0.391 |
CK2A2 |
0.670 | 0.012 | 1 | 0.307 |
PKCZ |
0.670 | -0.072 | 2 | 0.685 |
TAO3 |
0.670 | -0.017 | 1 | 0.314 |
DCAMKL2 |
0.670 | -0.058 | -3 | 0.381 |
PLK4 |
0.670 | -0.099 | 2 | 0.585 |
GRK3 |
0.670 | -0.027 | -2 | 0.538 |
PERK |
0.669 | -0.077 | -2 | 0.699 |
IRE2 |
0.669 | -0.093 | 2 | 0.687 |
PKCG |
0.669 | -0.092 | 2 | 0.624 |
MARK2 |
0.669 | -0.059 | 4 | 0.651 |
PAK3 |
0.669 | -0.118 | -2 | 0.561 |
CK1G1 |
0.668 | -0.075 | -3 | 0.202 |
MSK1 |
0.668 | -0.080 | -3 | 0.314 |
NEK2 |
0.667 | -0.147 | 2 | 0.724 |
PKG2 |
0.667 | -0.080 | -2 | 0.444 |
PKCH |
0.667 | -0.097 | 2 | 0.627 |
PIM2 |
0.667 | -0.055 | -3 | 0.321 |
QIK |
0.666 | -0.140 | -3 | 0.334 |
BRSK1 |
0.666 | -0.091 | -3 | 0.353 |
MEKK2 |
0.665 | -0.051 | 2 | 0.709 |
AKT1 |
0.665 | -0.059 | -3 | 0.307 |
WNK4 |
0.665 | -0.108 | -2 | 0.733 |
BRAF |
0.665 | -0.095 | -4 | 0.712 |
MAPKAPK5 |
0.665 | -0.112 | -3 | 0.257 |
CAMK4 |
0.665 | -0.170 | -3 | 0.352 |
TLK1 |
0.665 | -0.074 | -2 | 0.722 |
CK1A2 |
0.664 | -0.069 | -3 | 0.159 |
PKACA |
0.664 | -0.059 | -2 | 0.402 |
AURB |
0.663 | -0.080 | -2 | 0.427 |
ZAK |
0.663 | -0.121 | 1 | 0.278 |
RIPK1 |
0.663 | -0.256 | 1 | 0.247 |
NEK5 |
0.663 | -0.118 | 1 | 0.249 |
SBK |
0.663 | 0.026 | -3 | 0.262 |
SGK1 |
0.662 | -0.029 | -3 | 0.267 |
GSK3B |
0.662 | 0.011 | 4 | 0.406 |
MST3 |
0.662 | -0.087 | 2 | 0.720 |
BRSK2 |
0.662 | -0.123 | -3 | 0.340 |
MEKK1 |
0.661 | -0.122 | 1 | 0.278 |
HRI |
0.660 | -0.152 | -2 | 0.710 |
BUB1 |
0.660 | 0.024 | -5 | 0.720 |
DRAK1 |
0.660 | -0.146 | 1 | 0.304 |
MYLK4 |
0.660 | -0.112 | -2 | 0.553 |
MEK5 |
0.659 | -0.182 | 2 | 0.717 |
MARK1 |
0.659 | -0.100 | 4 | 0.693 |
AKT3 |
0.659 | -0.048 | -3 | 0.278 |
GAK |
0.658 | -0.030 | 1 | 0.325 |
AURA |
0.658 | -0.079 | -2 | 0.405 |
PAK2 |
0.658 | -0.135 | -2 | 0.541 |
MEKK3 |
0.658 | -0.154 | 1 | 0.287 |
CK2A1 |
0.658 | -0.013 | 1 | 0.302 |
TNIK |
0.658 | -0.018 | 3 | 0.778 |
PHKG2 |
0.657 | -0.113 | -3 | 0.344 |
LKB1 |
0.657 | -0.081 | -3 | 0.298 |
PDK1 |
0.656 | -0.080 | 1 | 0.306 |
TAO2 |
0.656 | -0.086 | 2 | 0.744 |
SSTK |
0.655 | -0.088 | 4 | 0.708 |
GCK |
0.655 | -0.076 | 1 | 0.296 |
PAK5 |
0.655 | -0.070 | -2 | 0.406 |
PKCT |
0.655 | -0.106 | 2 | 0.635 |
IRAK4 |
0.655 | -0.144 | 1 | 0.205 |
CAMK1G |
0.655 | -0.118 | -3 | 0.308 |
MAP3K15 |
0.654 | -0.087 | 1 | 0.276 |
PKCE |
0.654 | -0.061 | 2 | 0.619 |
EEF2K |
0.653 | -0.060 | 3 | 0.716 |
NEK11 |
0.653 | -0.160 | 1 | 0.306 |
CAMK1D |
0.653 | -0.089 | -3 | 0.314 |
P70S6K |
0.653 | -0.105 | -3 | 0.281 |
MST2 |
0.653 | -0.074 | 1 | 0.285 |
HGK |
0.652 | -0.078 | 3 | 0.757 |
PAK4 |
0.652 | -0.061 | -2 | 0.411 |
PKCI |
0.651 | -0.093 | 2 | 0.651 |
PKN1 |
0.650 | -0.092 | -3 | 0.288 |
CHK2 |
0.650 | -0.073 | -3 | 0.278 |
DAPK3 |
0.650 | -0.092 | -3 | 0.355 |
LRRK2 |
0.650 | -0.072 | 2 | 0.748 |
PBK |
0.649 | -0.054 | 1 | 0.269 |
KHS1 |
0.649 | -0.058 | 1 | 0.268 |
SMMLCK |
0.649 | -0.125 | -3 | 0.332 |
NEK8 |
0.649 | -0.168 | 2 | 0.717 |
SNRK |
0.649 | -0.216 | 2 | 0.607 |
HASPIN |
0.648 | -0.004 | -1 | 0.676 |
MINK |
0.648 | -0.108 | 1 | 0.248 |
ROCK2 |
0.647 | -0.057 | -3 | 0.342 |
MEKK6 |
0.647 | -0.130 | 1 | 0.261 |
SLK |
0.647 | -0.056 | -2 | 0.498 |
KHS2 |
0.646 | -0.054 | 1 | 0.288 |
TTBK1 |
0.646 | -0.164 | 2 | 0.571 |
MRCKA |
0.645 | -0.073 | -3 | 0.322 |
MRCKB |
0.644 | -0.074 | -3 | 0.308 |
DAPK1 |
0.644 | -0.096 | -3 | 0.332 |
HPK1 |
0.644 | -0.121 | 1 | 0.291 |
NEK1 |
0.644 | -0.162 | 1 | 0.230 |
VRK1 |
0.644 | -0.143 | 2 | 0.787 |
LOK |
0.644 | -0.092 | -2 | 0.545 |
NEK4 |
0.644 | -0.184 | 1 | 0.231 |
CAMKK1 |
0.644 | -0.214 | -2 | 0.576 |
CAMKK2 |
0.643 | -0.182 | -2 | 0.563 |
MST1 |
0.643 | -0.111 | 1 | 0.267 |
CAMK1A |
0.642 | -0.087 | -3 | 0.298 |
OSR1 |
0.640 | -0.034 | 2 | 0.682 |
MEK2 |
0.639 | -0.170 | 2 | 0.730 |
IRAK1 |
0.639 | -0.230 | -1 | 0.666 |
DMPK1 |
0.638 | -0.052 | -3 | 0.340 |
TTK |
0.638 | -0.012 | -2 | 0.684 |
YSK1 |
0.637 | -0.128 | 2 | 0.707 |
ALPHAK3 |
0.637 | -0.019 | -1 | 0.700 |
CK1A |
0.637 | -0.079 | -3 | 0.119 |
TAK1 |
0.636 | -0.216 | 1 | 0.271 |
ASK1 |
0.635 | -0.098 | 1 | 0.284 |
CRIK |
0.634 | -0.065 | -3 | 0.312 |
BIKE |
0.633 | -0.044 | 1 | 0.279 |
AAK1 |
0.632 | -0.003 | 1 | 0.250 |
TAO1 |
0.631 | -0.090 | 1 | 0.251 |
ROCK1 |
0.631 | -0.083 | -3 | 0.315 |
STK33 |
0.630 | -0.151 | 2 | 0.521 |
NEK3 |
0.630 | -0.162 | 1 | 0.234 |
PDHK3_TYR |
0.628 | 0.082 | 4 | 0.825 |
PKG1 |
0.627 | -0.112 | -2 | 0.371 |
MYO3B |
0.626 | -0.096 | 2 | 0.723 |
MYO3A |
0.625 | -0.097 | 1 | 0.256 |
RIPK2 |
0.624 | -0.261 | 1 | 0.249 |
PKMYT1_TYR |
0.621 | 0.067 | 3 | 0.733 |
YANK3 |
0.620 | -0.081 | 2 | 0.330 |
TESK1_TYR |
0.619 | -0.021 | 3 | 0.772 |
LIMK2_TYR |
0.618 | 0.033 | -3 | 0.372 |
MAP2K4_TYR |
0.616 | -0.026 | -1 | 0.777 |
MAP2K6_TYR |
0.614 | -0.006 | -1 | 0.776 |
PDHK4_TYR |
0.613 | -0.030 | 2 | 0.733 |
BMPR2_TYR |
0.613 | 0.005 | -1 | 0.763 |
CK1G3 |
0.612 | -0.098 | -3 | 0.093 |
CSF1R |
0.612 | 0.041 | 3 | 0.684 |
ABL2 |
0.612 | 0.059 | -1 | 0.679 |
PDHK1_TYR |
0.612 | -0.036 | -1 | 0.784 |
PINK1_TYR |
0.611 | -0.093 | 1 | 0.352 |
MAP2K7_TYR |
0.611 | -0.118 | 2 | 0.748 |
STLK3 |
0.611 | -0.168 | 1 | 0.259 |
YES1 |
0.611 | 0.044 | -1 | 0.747 |
TXK |
0.610 | 0.036 | 1 | 0.316 |
JAK2 |
0.608 | -0.057 | 1 | 0.302 |
FYN |
0.608 | 0.071 | -1 | 0.714 |
EPHA6 |
0.608 | -0.032 | -1 | 0.729 |
LIMK1_TYR |
0.608 | -0.064 | 2 | 0.762 |
ABL1 |
0.607 | 0.037 | -1 | 0.676 |
RET |
0.607 | -0.055 | 1 | 0.304 |
LCK |
0.606 | 0.021 | -1 | 0.722 |
BLK |
0.604 | 0.026 | -1 | 0.722 |
MST1R |
0.604 | -0.083 | 3 | 0.697 |
EPHB4 |
0.604 | -0.039 | -1 | 0.688 |
HCK |
0.604 | -0.031 | -1 | 0.713 |
ROS1 |
0.603 | -0.092 | 3 | 0.647 |
TYK2 |
0.603 | -0.144 | 1 | 0.285 |
TYRO3 |
0.603 | -0.081 | 3 | 0.688 |
FGR |
0.603 | -0.064 | 1 | 0.295 |
FER |
0.603 | -0.039 | 1 | 0.332 |
KIT |
0.601 | -0.022 | 3 | 0.682 |
FGFR2 |
0.600 | -0.003 | 3 | 0.650 |
JAK1 |
0.600 | -0.073 | 1 | 0.266 |
SRMS |
0.599 | -0.044 | 1 | 0.316 |
EPHA4 |
0.598 | -0.040 | 2 | 0.659 |
EGFR |
0.598 | 0.016 | 1 | 0.327 |
FLT3 |
0.598 | -0.053 | 3 | 0.683 |
MET |
0.597 | -0.018 | 3 | 0.685 |
JAK3 |
0.597 | -0.103 | 1 | 0.301 |
CK1G2 |
0.597 | -0.090 | -3 | 0.150 |
TNK1 |
0.597 | -0.070 | 3 | 0.679 |
FRK |
0.597 | -0.004 | -1 | 0.702 |
SRC |
0.596 | 0.025 | -1 | 0.711 |
EPHB2 |
0.596 | -0.038 | -1 | 0.659 |
FGFR1 |
0.596 | -0.038 | 3 | 0.629 |
TEK |
0.595 | -0.042 | 3 | 0.619 |
MERTK |
0.595 | -0.045 | 3 | 0.665 |
INSRR |
0.595 | -0.072 | 3 | 0.614 |
DDR1 |
0.595 | -0.148 | 4 | 0.745 |
LYN |
0.594 | 0.001 | 3 | 0.601 |
ITK |
0.594 | -0.071 | -1 | 0.673 |
KDR |
0.594 | -0.065 | 3 | 0.640 |
TNNI3K_TYR |
0.593 | -0.071 | 1 | 0.281 |
YANK2 |
0.593 | -0.089 | 2 | 0.339 |
EPHB1 |
0.593 | -0.101 | 1 | 0.309 |
CSK |
0.593 | 0.034 | 2 | 0.671 |
NEK10_TYR |
0.592 | -0.118 | 1 | 0.247 |
FGFR3 |
0.592 | -0.011 | 3 | 0.629 |
TNK2 |
0.592 | -0.120 | 3 | 0.644 |
ERBB2 |
0.592 | -0.058 | 1 | 0.338 |
SYK |
0.592 | 0.014 | -1 | 0.654 |
PTK2B |
0.591 | -0.029 | -1 | 0.659 |
MATK |
0.590 | -0.007 | -1 | 0.624 |
FGFR4 |
0.590 | 0.011 | -1 | 0.645 |
EPHB3 |
0.590 | -0.104 | -1 | 0.663 |
PDGFRB |
0.590 | -0.142 | 3 | 0.685 |
AXL |
0.589 | -0.112 | 3 | 0.654 |
BMX |
0.589 | -0.069 | -1 | 0.604 |
PTK2 |
0.589 | 0.008 | -1 | 0.676 |
EPHA8 |
0.588 | -0.006 | -1 | 0.655 |
ERBB4 |
0.588 | 0.003 | 1 | 0.346 |
TEC |
0.588 | -0.072 | -1 | 0.615 |
PTK6 |
0.588 | -0.071 | -1 | 0.620 |
BTK |
0.587 | -0.102 | -1 | 0.635 |
ALK |
0.587 | -0.093 | 3 | 0.582 |
NTRK3 |
0.586 | -0.065 | -1 | 0.624 |
PDGFRA |
0.586 | -0.158 | 3 | 0.689 |
WEE1_TYR |
0.586 | -0.090 | -1 | 0.657 |
INSR |
0.586 | -0.086 | 3 | 0.603 |
NTRK1 |
0.585 | -0.111 | -1 | 0.667 |
EPHA7 |
0.584 | -0.086 | 2 | 0.668 |
LTK |
0.583 | -0.098 | 3 | 0.606 |
FLT1 |
0.583 | -0.094 | -1 | 0.695 |
EPHA1 |
0.583 | -0.106 | 3 | 0.658 |
NTRK2 |
0.581 | -0.126 | 3 | 0.627 |
EPHA3 |
0.580 | -0.115 | 2 | 0.638 |
ZAP70 |
0.580 | 0.010 | -1 | 0.599 |
EPHA5 |
0.579 | -0.061 | 2 | 0.647 |
FLT4 |
0.579 | -0.120 | 3 | 0.620 |
MUSK |
0.578 | -0.081 | 1 | 0.296 |
IGF1R |
0.576 | -0.054 | 3 | 0.546 |
DDR2 |
0.575 | -0.102 | 3 | 0.586 |
EPHA2 |
0.575 | -0.050 | -1 | 0.615 |
FES |
0.564 | -0.080 | -1 | 0.593 |