Motif 1 (n=46)

Position-wise Probabilities

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uniprot	genes	site	source	protein	function
O75369	FLNB	S341	ochoa	Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP)	Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O75369	FLNB	S440	ochoa	Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP)	Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O75369	FLNB	S730	ochoa	Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP)	Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O75369	FLNB	S833	ochoa	Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP)	Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O75369	FLNB	S932	ochoa	Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP)	Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O75369	FLNB	S1028	ochoa	Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP)	Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O75369	FLNB	S1121	ochoa	Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP)	Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O75369	FLNB	S1316	ochoa	Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP)	Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O75369	FLNB	S1409	ochoa	Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP)	Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O75369	FLNB	S1505	ochoa	Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP)	Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O75369	FLNB	S1602	ochoa	Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP)	Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O75369	FLNB	S1902	ochoa	Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP)	Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O75369	FLNB	S1988	ochoa	Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP)	Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O75369	FLNB	S2083	ochoa	Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP)	Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O75369	FLNB	S2179	ochoa	Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP)	Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O75369	FLNB	S2274	ochoa	Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP)	Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O75369	FLNB	S2369	ochoa	Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP)	Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
P21333	FLNA	S368	ochoa	Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)	Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250\|UniProtKB:Q8BTM8, ECO:0000269\|PubMed:22121117, ECO:0000269\|PubMed:25358863}.
P21333	FLNA	S468	ochoa	Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)	Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250\|UniProtKB:Q8BTM8, ECO:0000269\|PubMed:22121117, ECO:0000269\|PubMed:25358863}.
P21333	FLNA	S657	ochoa	Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)	Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250\|UniProtKB:Q8BTM8, ECO:0000269\|PubMed:22121117, ECO:0000269\|PubMed:25358863}.
P21333	FLNA	S757	ochoa	Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)	Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250\|UniProtKB:Q8BTM8, ECO:0000269\|PubMed:22121117, ECO:0000269\|PubMed:25358863}.
P21333	FLNA	S860	ochoa	Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)	Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250\|UniProtKB:Q8BTM8, ECO:0000269\|PubMed:22121117, ECO:0000269\|PubMed:25358863}.
P21333	FLNA	S959	ochoa	Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)	Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250\|UniProtKB:Q8BTM8, ECO:0000269\|PubMed:22121117, ECO:0000269\|PubMed:25358863}.
P21333	FLNA	S1055	ochoa	Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)	Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250\|UniProtKB:Q8BTM8, ECO:0000269\|PubMed:22121117, ECO:0000269\|PubMed:25358863}.
P21333	FLNA	S1343	ochoa	Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)	Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250\|UniProtKB:Q8BTM8, ECO:0000269\|PubMed:22121117, ECO:0000269\|PubMed:25358863}.
P21333	FLNA	S1436	ochoa\|psp	Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)	Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250\|UniProtKB:Q8BTM8, ECO:0000269\|PubMed:22121117, ECO:0000269\|PubMed:25358863}.
P21333	FLNA	S1533	ochoa\|psp	Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)	Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250\|UniProtKB:Q8BTM8, ECO:0000269\|PubMed:22121117, ECO:0000269\|PubMed:25358863}.
P21333	FLNA	S1630	ochoa\|psp	Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)	Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250\|UniProtKB:Q8BTM8, ECO:0000269\|PubMed:22121117, ECO:0000269\|PubMed:25358863}.
P21333	FLNA	S1734	ochoa	Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)	Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250\|UniProtKB:Q8BTM8, ECO:0000269\|PubMed:22121117, ECO:0000269\|PubMed:25358863}.
P21333	FLNA	S1946	ochoa	Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)	Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250\|UniProtKB:Q8BTM8, ECO:0000269\|PubMed:22121117, ECO:0000269\|PubMed:25358863}.
P21333	FLNA	S2033	ochoa	Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)	Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250\|UniProtKB:Q8BTM8, ECO:0000269\|PubMed:22121117, ECO:0000269\|PubMed:25358863}.
P21333	FLNA	S2128	ochoa	Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)	Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250\|UniProtKB:Q8BTM8, ECO:0000269\|PubMed:22121117, ECO:0000269\|PubMed:25358863}.
P21333	FLNA	S2224	ochoa	Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)	Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250\|UniProtKB:Q8BTM8, ECO:0000269\|PubMed:22121117, ECO:0000269\|PubMed:25358863}.
P21333	FLNA	S2319	ochoa	Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)	Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250\|UniProtKB:Q8BTM8, ECO:0000269\|PubMed:22121117, ECO:0000269\|PubMed:25358863}.
P21333	FLNA	S2414	ochoa	Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)	Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250\|UniProtKB:Q8BTM8, ECO:0000269\|PubMed:22121117, ECO:0000269\|PubMed:25358863}.
Q14315	FLNC	S462	ochoa	Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin)	Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250\|UniProtKB:Q8VHX6, ECO:0000269\|PubMed:34405687}.
Q14315	FLNC	S559	ochoa	Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin)	Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250\|UniProtKB:Q8VHX6, ECO:0000269\|PubMed:34405687}.
Q14315	FLNC	S954	ochoa	Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin)	Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250\|UniProtKB:Q8VHX6, ECO:0000269\|PubMed:34405687}.
Q14315	FLNC	S1050	ochoa	Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin)	Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250\|UniProtKB:Q8VHX6, ECO:0000269\|PubMed:34405687}.
Q14315	FLNC	S1527	ochoa	Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin)	Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250\|UniProtKB:Q8VHX6, ECO:0000269\|PubMed:34405687}.
Q14315	FLNC	S1624	ochoa	Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin)	Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250\|UniProtKB:Q8VHX6, ECO:0000269\|PubMed:34405687}.
Q14315	FLNC	S1728	ochoa	Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin)	Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250\|UniProtKB:Q8VHX6, ECO:0000269\|PubMed:34405687}.
Q14315	FLNC	S1848	ochoa	Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin)	Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250\|UniProtKB:Q8VHX6, ECO:0000269\|PubMed:34405687}.
Q14315	FLNC	S1940	ochoa	Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin)	Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250\|UniProtKB:Q8VHX6, ECO:0000269\|PubMed:34405687}.
Q14315	FLNC	S2300	ochoa	Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin)	Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250\|UniProtKB:Q8VHX6, ECO:0000269\|PubMed:34405687}.
Q14315	FLNC	S2395	ochoa	Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin)	Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250\|UniProtKB:Q8VHX6, ECO:0000269\|PubMed:34405687}.

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reactome_id	name	p	-log10_p
R-HSA-446353	Cell-extracellular matrix interactions	0.000004	5.380
R-HSA-1169410	Antiviral mechanism by IFN-stimulated genes	0.000340	3.469
R-HSA-446728	Cell junction organization	0.001015	2.994
R-HSA-1500931	Cell-Cell communication	0.001288	2.890
R-HSA-913531	Interferon Signaling	0.001857	2.731
R-HSA-430116	GP1b-IX-V activation signalling	0.002234	2.651
R-HSA-8983711	OAS antiviral response	0.002978	2.526
R-HSA-1169408	ISG15 antiviral mechanism	0.015383	1.813
R-HSA-1280215	Cytokine Signaling in Immune system	0.013243	1.878
R-HSA-114608	Platelet degranulation	0.026222	1.581
R-HSA-76005	Response to elevated platelet cytosolic Ca2+	0.027503	1.561
R-HSA-76002	Platelet activation, signaling and aggregation	0.053778	1.269
R-HSA-168256	Immune System	0.079815	1.098
R-HSA-109582	Hemostasis	0.142600	0.846
R-HSA-162582	Signal Transduction	0.467266	0.330

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kinase	JSD_mean	pearson_surrounding	kinase_max_IC_position	max_position_JSD
CDK19	0.548	0.589	1	0.779
CDK8	0.544	0.593	1	0.739
CDK3	0.539	0.495	1	0.823
CDK18	0.537	0.541	1	0.796
CDK17	0.536	0.538	1	0.832
HIPK2	0.536	0.499	1	0.776
CDK1	0.534	0.531	1	0.772
ERK1	0.533	0.585	1	0.775
P38G	0.533	0.547	1	0.841
P38D	0.531	0.551	1	0.838
CDK5	0.530	0.533	1	0.711
KIS	0.528	0.437	1	0.712
P38B	0.527	0.598	1	0.758
CDK13	0.526	0.517	1	0.766
CDK12	0.524	0.513	1	0.790
CDK7	0.522	0.529	1	0.742
CDK16	0.521	0.504	1	0.817
MAK	0.518	0.484	-2	0.763
DYRK4	0.517	0.454	1	0.785
CDK6	0.517	0.506	1	0.771
HIPK4	0.514	0.413	1	0.449
CDK4	0.514	0.515	1	0.799
ERK2	0.513	0.549	1	0.719
JNK2	0.513	0.524	1	0.792
CDK9	0.512	0.488	1	0.758
DYRK1A	0.512	0.441	1	0.636
P38A	0.511	0.582	1	0.679
CDK2	0.511	0.430	1	0.637
CDK10	0.510	0.457	1	0.768
DYRK2	0.510	0.463	1	0.679
CDK14	0.507	0.490	1	0.750
JNK3	0.506	0.509	1	0.761
DYRK1B	0.505	0.433	1	0.737
JNK1	0.501	0.465	1	0.794
HIPK1	0.500	0.419	1	0.657
HIPK3	0.496	0.424	1	0.628
CLK3	0.493	0.278	1	0.416
ICK	0.489	0.390	-3	0.171
DYRK3	0.487	0.317	1	0.619
CDKL5	0.484	0.242	-3	0.175
SRPK2	0.484	0.149	-3	0.102
MOK	0.483	0.389	1	0.541
NLK	0.482	0.422	1	0.452
SRPK1	0.478	0.169	-3	0.134
ERK5	0.475	0.271	1	0.367
CLK2	0.475	0.183	-3	0.093
CLK1	0.473	0.200	-3	0.132
MTOR	0.473	0.185	1	0.242
CDKL1	0.471	0.186	-3	0.172
PRP4	0.470	0.263	-3	0.141
ERK7	0.465	0.157	2	0.127
CLK4	0.463	0.164	-3	0.129
MPSK1	0.462	0.262	1	0.123
CHAK2	0.458	0.059	-1	0.682
PLK4	0.458	0.024	2	0.476
SRPK3	0.458	0.110	-3	0.130
NIM1	0.454	0.039	3	0.530
TBK1	0.451	-0.037	1	0.037
ULK1	0.451	-0.095	-3	0.188
ULK2	0.450	-0.110	2	0.329
WNK3	0.449	-0.013	1	0.049
NDR2	0.448	-0.043	-3	0.112
COT	0.448	-0.149	2	0.257
MARK4	0.447	-0.013	4	0.434
CK1E	0.446	-0.015	-3	0.118
IRE1	0.446	-0.016	1	0.048
GSK3A	0.446	0.096	4	0.077
PAK1	0.446	-0.032	-2	0.353
CDC7	0.445	-0.064	1	0.068
ATR	0.445	-0.001	1	0.104
GCN2	0.445	-0.158	2	0.288
PINK1	0.445	0.084	1	0.269
PRPK	0.445	-0.031	-1	0.588
WNK1	0.444	-0.037	-2	0.375
MST4	0.444	-0.047	2	0.177
GRK1	0.444	-0.064	-2	0.306
PAK3	0.443	-0.043	-2	0.324
GRK7	0.442	-0.011	1	0.086
CAMK2G	0.442	-0.084	2	0.330
MOS	0.441	-0.062	1	0.107
SNRK	0.441	0.025	2	0.526
CHAK1	0.440	0.004	2	0.364
IRE2	0.440	-0.020	2	0.298
BRSK2	0.439	-0.024	-3	0.139
PKCG	0.439	-0.041	2	0.259
MARK2	0.439	-0.012	4	0.469
IKKE	0.438	-0.121	1	0.037
PDHK1	0.438	-0.088	1	0.094
PDHK4	0.438	-0.113	1	0.115
MARK3	0.438	-0.021	4	0.432
MLK3	0.438	-0.031	2	0.222
PKACG	0.438	-0.063	-2	0.255
CAMK1B	0.437	-0.075	-3	0.204
TTBK2	0.437	-0.102	2	0.379
PAK6	0.437	-0.047	-2	0.264
BCKDK	0.437	-0.085	-1	0.652
FAM20C	0.437	-0.055	2	0.162
NDR1	0.436	-0.079	-3	0.125
PKCD	0.436	-0.061	2	0.245
SIK	0.435	-0.052	-3	0.114
PIM3	0.435	-0.088	-3	0.121
QSK	0.435	-0.035	4	0.425
IKKA	0.435	-0.130	-2	0.245
CK1G1	0.435	-0.060	-3	0.103
RAF1	0.435	-0.175	1	0.049
MNK2	0.435	-0.056	-2	0.286
SKMLCK	0.434	-0.060	-2	0.358
PAK2	0.434	-0.039	-2	0.329
PKCZ	0.434	-0.042	2	0.257
BRSK1	0.434	-0.051	-3	0.109
PKCA	0.434	-0.037	2	0.224
NEK6	0.434	-0.138	-2	0.260
QIK	0.433	-0.059	-3	0.189
NUAK2	0.433	-0.063	-3	0.156
TSSK1	0.433	-0.043	-3	0.160
AMPKA1	0.432	-0.074	-3	0.151
HUNK	0.432	-0.160	2	0.342
MASTL	0.432	-0.086	-2	0.293
GRK5	0.431	-0.138	-3	0.246
SSTK	0.431	-0.026	4	0.461
DCAMKL2	0.431	-0.034	-3	0.123
PKN3	0.431	-0.105	-3	0.152
MLK1	0.431	-0.114	2	0.245
BMPR2	0.431	-0.202	-2	0.300
AURC	0.431	-0.051	-2	0.237
STK33	0.430	-0.016	2	0.448
PKCH	0.430	-0.067	2	0.259
RIPK1	0.430	-0.089	1	0.038
NEK7	0.430	-0.201	-3	0.164
NUAK1	0.430	-0.076	-3	0.119
PKN2	0.430	-0.116	-3	0.164
PKCB	0.430	-0.071	2	0.195
DSTYK	0.429	-0.207	2	0.224
CK1D	0.429	-0.042	-3	0.117
MNK1	0.429	-0.064	-2	0.286
PHKG2	0.429	-0.064	-3	0.168
TTBK1	0.428	-0.054	2	0.427
NIK	0.428	-0.115	-3	0.188
IKKB	0.428	-0.218	-2	0.228
CAMLCK	0.428	-0.062	-2	0.319
DAPK2	0.428	-0.072	-3	0.198
CK1A2	0.428	-0.049	-3	0.114
AMPKA2	0.428	-0.072	-3	0.131
MLK4	0.428	-0.076	2	0.224
SGK3	0.428	-0.058	-3	0.130
PRKX	0.428	-0.058	-3	0.067
RIPK3	0.427	-0.099	3	0.504
MARK1	0.427	-0.048	4	0.423
RSK3	0.427	-0.091	-3	0.123
WNK4	0.427	-0.017	-2	0.377
ATM	0.427	-0.083	1	0.077
GRK4	0.427	-0.148	-2	0.284
LATS2	0.426	-0.088	-5	0.551
MLK2	0.426	-0.074	2	0.240
TGFBR2	0.426	-0.129	-2	0.227
PKACB	0.425	-0.062	-2	0.222
VRK2	0.425	0.078	1	0.151
TSSK2	0.425	-0.075	-5	0.498
MAP3K15	0.425	0.096	1	0.062
DCAMKL1	0.425	-0.069	-3	0.088
DNAPK	0.424	-0.048	1	0.107
GSK3B	0.423	-0.002	4	0.078
PKCT	0.423	-0.077	2	0.250
IRAK4	0.423	-0.043	1	0.029
PHKG1	0.423	-0.094	-3	0.117
PAK5	0.423	-0.068	-2	0.258
PIM1	0.423	-0.081	-3	0.110
LATS1	0.422	-0.054	-3	0.115
PKCI	0.422	-0.055	2	0.240
PAK4	0.422	-0.064	-2	0.266
CAMK1G	0.422	-0.084	-3	0.140
SMG1	0.422	-0.067	1	0.094
MSK2	0.422	-0.095	-3	0.108
DLK	0.422	-0.168	1	0.062
TLK2	0.421	-0.100	1	0.042
PKG2	0.421	-0.072	-2	0.232
RSK4	0.421	-0.073	-3	0.094
AKT2	0.421	-0.060	-3	0.113
P70S6KB	0.421	-0.100	-3	0.148
PRKD3	0.420	-0.082	-3	0.122
ANKRD3	0.420	-0.173	1	0.063
TGFBR1	0.420	-0.091	-2	0.246
AURB	0.420	-0.061	-2	0.226
PRKD1	0.420	-0.124	-3	0.123
GRK2	0.419	-0.087	-2	0.250
PKCE	0.419	-0.044	2	0.246
RSK2	0.419	-0.101	-3	0.138
YANK3	0.419	-0.011	2	0.350
MELK	0.419	-0.113	-3	0.132
TAO3	0.419	-0.041	1	0.084
CK1A	0.418	-0.052	-3	0.088
GRK6	0.418	-0.168	1	0.048
MEK1	0.418	-0.120	2	0.290
PRKD2	0.418	-0.107	-3	0.100
PKACA	0.417	-0.065	-2	0.201
HASPIN	0.417	0.052	-1	0.644
PKR	0.417	-0.093	1	0.066
AKT1	0.417	-0.064	-3	0.104
ALK4	0.417	-0.104	-2	0.264
P90RSK	0.417	-0.100	-3	0.123
AURA	0.415	-0.080	-2	0.218
NEK2	0.415	-0.156	2	0.268
MYLK4	0.415	-0.087	-2	0.273
MEKK6	0.414	-0.002	1	0.060
NEK9	0.414	-0.223	2	0.258
ZAK	0.414	-0.128	1	0.047
MSK1	0.414	-0.092	-3	0.114
BMPR1B	0.413	-0.121	1	0.042
PIM2	0.413	-0.064	-3	0.139
PLK1	0.412	-0.169	-2	0.211
SGK1	0.412	-0.044	-3	0.076
AKT3	0.411	-0.062	-3	0.072
CAMK2D	0.411	-0.170	-3	0.174
TLK1	0.411	-0.128	-2	0.260
CAMK2A	0.410	-0.116	2	0.260
ACVR2B	0.410	-0.136	-2	0.227
PLK3	0.410	-0.141	2	0.375
YSK4	0.410	-0.183	1	0.039
DRAK1	0.410	-0.149	1	0.032
MEK5	0.409	-0.122	2	0.291
CAMK4	0.409	-0.168	-3	0.149
MEKK3	0.409	-0.152	1	0.057
GRK3	0.408	-0.103	-2	0.232
PDK1	0.408	-0.034	1	0.091
PKN1	0.408	-0.087	-3	0.139
MEKK2	0.407	-0.125	2	0.271
MST3	0.407	-0.097	2	0.213
MEKK1	0.407	-0.141	1	0.060
LRRK2	0.407	0.016	2	0.326
TAO2	0.407	-0.055	2	0.264
ACVR2A	0.406	-0.137	-2	0.219
PASK	0.406	-0.076	-3	0.148
HRI	0.405	-0.153	-2	0.266
MAPKAPK2	0.405	-0.126	-3	0.069
MAPKAPK3	0.405	-0.157	-3	0.096
P70S6K	0.405	-0.099	-3	0.132
CAMK2B	0.405	-0.153	2	0.268
SMMLCK	0.404	-0.076	-3	0.188
EEF2K	0.404	0.010	3	0.771
IRAK1	0.404	-0.149	-1	0.551
CK2A2	0.404	-0.086	1	0.038
PKG1	0.404	-0.076	-2	0.186
PERK	0.404	-0.165	-2	0.242
NEK11	0.404	-0.103	1	0.077
HGK	0.403	-0.048	3	0.770
SBK	0.403	-0.009	-3	0.068
PBK	0.402	-0.027	1	0.095
BRAF	0.402	-0.168	-4	0.479
BMPR1A	0.402	-0.116	1	0.035
MRCKA	0.402	-0.058	-3	0.115
MRCKB	0.401	-0.063	-3	0.132
TNIK	0.400	-0.052	3	0.768
GAK	0.400	-0.060	1	0.106
MINK	0.399	-0.081	1	0.038
BUB1	0.399	-0.033	-5	0.429
MAPKAPK5	0.399	-0.160	-3	0.101
NEK8	0.398	-0.156	2	0.316
CAMK1D	0.398	-0.101	-3	0.071
CAMKK1	0.398	-0.169	-2	0.203
ALK2	0.398	-0.154	-2	0.237
CK2A1	0.397	-0.092	1	0.032
GCK	0.397	-0.090	1	0.063
KHS2	0.397	-0.031	1	0.069
YANK2	0.397	-0.023	2	0.346
SLK	0.396	-0.096	-2	0.249
LKB1	0.396	-0.116	-3	0.141
KHS1	0.396	-0.044	1	0.058
RIPK2	0.396	-0.116	1	0.034
CAMK1A	0.395	-0.087	-3	0.079
PLK2	0.395	-0.101	-3	0.119
HPK1	0.395	-0.092	1	0.065
NEK5	0.395	-0.195	1	0.044
DAPK3	0.394	-0.094	-3	0.121
CHK1	0.394	-0.162	-3	0.110
MST2	0.394	-0.147	1	0.046
MEK2	0.393	-0.108	2	0.297
YSK1	0.393	-0.086	2	0.227
MST1	0.393	-0.110	1	0.037
CHK2	0.392	-0.087	-3	0.090
LOK	0.392	-0.112	-2	0.251
CAMKK2	0.392	-0.169	-2	0.222
ROCK2	0.391	-0.076	-3	0.116
ASK1	0.391	-0.011	1	0.063
MYO3A	0.390	-0.045	1	0.056
NEK4	0.388	-0.168	1	0.035
CK1G3	0.388	-0.078	-3	0.078
DAPK1	0.388	-0.105	-3	0.135
TAO1	0.387	-0.075	1	0.059
TAK1	0.386	-0.178	1	0.038
NEK3	0.385	-0.137	1	0.063
VRK1	0.383	-0.137	2	0.304
DMPK1	0.383	-0.060	-3	0.134
ROCK1	0.383	-0.084	-3	0.114
MYO3B	0.382	-0.068	2	0.241
BIKE	0.382	-0.030	1	0.110
OSR1	0.381	-0.122	2	0.233
ALPHAK3	0.380	-0.052	-1	0.506
CRIK	0.380	-0.070	-3	0.111
CK1G2	0.379	-0.071	-3	0.088
NEK1	0.379	-0.180	1	0.029
EPHA6	0.376	0.008	-1	0.564
PKMYT1_TYR	0.375	0.114	3	0.618
AAK1	0.374	-0.019	1	0.128
LIMK2_TYR	0.374	0.059	-3	0.196
PDHK3_TYR	0.373	0.016	4	0.309
LIMK1_TYR	0.371	0.039	2	0.333
MAP2K7_TYR	0.370	-0.009	2	0.350
DDR1	0.369	-0.023	4	0.374
BMPR2_TYR	0.369	-0.038	-1	0.615
TESK1_TYR	0.368	-0.022	3	0.679
PDHK1_TYR	0.367	-0.010	-1	0.594
PINK1_TYR	0.367	-0.088	1	0.106
FGFR1	0.365	0.011	3	0.542
MAP2K6_TYR	0.365	-0.066	-1	0.613
STLK3	0.364	-0.151	1	0.034
MAP2K4_TYR	0.364	-0.063	-1	0.615
TTK	0.363	-0.163	-2	0.245
TNNI3K_TYR	0.363	-0.009	1	0.091
TNK1	0.361	-0.003	3	0.564
PDHK4_TYR	0.361	-0.078	2	0.293
EPHA4	0.361	-0.034	2	0.365
FGFR2	0.361	-0.024	3	0.569
WEE1_TYR	0.360	-0.021	-1	0.526
EPHB4	0.360	-0.056	-1	0.546
CSF1R	0.359	-0.056	3	0.580
ROS1	0.358	-0.063	3	0.579
JAK2	0.358	-0.072	1	0.086
FLT3	0.357	-0.077	3	0.616
TYRO3	0.357	-0.097	3	0.615
MST1R	0.357	-0.096	3	0.581
TEK	0.357	-0.022	3	0.549
TNK2	0.356	-0.030	3	0.541
PDGFRB	0.356	-0.082	3	0.598
PDGFRA	0.356	-0.050	3	0.606
TYK2	0.355	-0.136	1	0.063
NEK10_TYR	0.354	-0.076	1	0.068
JAK3	0.354	-0.102	1	0.071
EPHB2	0.354	-0.070	-1	0.513
DDR2	0.354	-0.028	3	0.539
RET	0.353	-0.145	1	0.076
FGFR3	0.353	-0.049	3	0.541
EPHA3	0.351	-0.063	2	0.397
EPHB1	0.351	-0.096	1	0.033
EPHB3	0.350	-0.080	-1	0.528
EPHA7	0.350	-0.056	2	0.388
ITK	0.350	-0.086	-1	0.481
INSRR	0.349	-0.101	3	0.546
KDR	0.349	-0.091	3	0.537
FRK	0.347	-0.077	-1	0.485
TXK	0.347	-0.083	1	0.036
KIT	0.347	-0.112	3	0.580
PTK2	0.346	-0.047	-1	0.510
MET	0.346	-0.093	3	0.559
BTK	0.346	-0.102	-1	0.460
JAK1	0.345	-0.092	1	0.061
EPHA8	0.344	-0.068	-1	0.505
CSK	0.344	-0.048	2	0.399
FER	0.344	-0.145	1	0.051
ERBB2	0.344	-0.109	1	0.051
INSR	0.344	-0.091	3	0.515
YES1	0.344	-0.108	-1	0.490
FLT4	0.344	-0.094	3	0.519
MUSK	0.344	-0.067	1	0.020
MERTK	0.343	-0.105	3	0.536
EPHA1	0.343	-0.084	3	0.549
MATK	0.343	-0.082	-1	0.450
EPHA5	0.343	-0.087	2	0.380
EGFR	0.343	-0.083	1	0.037
AXL	0.343	-0.121	3	0.544
ABL1	0.342	-0.124	-1	0.475
PTK2B	0.342	-0.063	-1	0.444
ABL2	0.341	-0.132	-1	0.485
NTRK2	0.340	-0.121	3	0.528
FGFR4	0.340	-0.083	-1	0.463
FLT1	0.339	-0.129	-1	0.543
ALK	0.338	-0.116	3	0.520
HCK	0.338	-0.152	-1	0.472
LCK	0.338	-0.126	-1	0.471
BMX	0.337	-0.101	-1	0.411
BLK	0.337	-0.119	-1	0.473
SRMS	0.336	-0.168	1	0.027
NTRK1	0.336	-0.151	-1	0.527
ERBB4	0.336	-0.075	1	0.036
EPHA2	0.335	-0.085	-1	0.490
LTK	0.335	-0.124	3	0.512
TEC	0.335	-0.125	-1	0.421
PTK6	0.334	-0.147	-1	0.432
NTRK3	0.333	-0.116	-1	0.484
SYK	0.333	-0.101	-1	0.464
FGR	0.333	-0.203	1	0.038
IGF1R	0.333	-0.090	3	0.451
FYN	0.332	-0.107	-1	0.440
SRC	0.327	-0.115	-1	0.437
FES	0.326	-0.077	-1	0.394
ZAP70	0.326	-0.079	-1	0.438
LYN	0.326	-0.142	3	0.493