WNK2

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Y Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Log-Odds: Y Sites / Y Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A5A3E0 T949 Sugiyama POTEF A26C1B TVAsSSSLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
A6NKT7 S980 Sugiyama RGPD3 RGP3 GVIFGQTSSTFTFADVAKstsGEGFQFGKKDLNFKGFSGAG
O14715 S979 Sugiyama RGPD8 RANBP2ALPHA RANBP2L1 RANBP2L3 GVIFGQTSSTFTFADVAKstsGEGFQFGKKDLNFKGFSGAG
O43707 S763 Sugiyama ACTN4 IARTINEVENQILtRDAKGIsQEQMQEFRASFNHFDKDHGG
O60841 S182 Sugiyama EIF5B IF2 KIAA0741 DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O75821 S28 Sugiyama EIF3G EIF3S4 sKPsWADQVEEEGEDDKCVtsELLKGIPLAtGDtsPEPELL
P00558 S393 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 GGDtAtCCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDA
P00558 S399 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 CCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDALsNI__
P00558 T394 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 GDtAtCCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDAL
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04083 S170 Sugiyama ANXA1 ANX1 LPC1 RDINRVYREELKRDLAKDItsDtsGDFRNALLsLAKGDRsE
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 Y314 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 tFDAGAGIALNDHFVKLIsWyDNEFGysNRVVDLMAHMAsK
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05783 S305 Sugiyama KRT18 CYK18 PIG46 QSAEVGAAETTLTELRRtVQsLEIDLDsMRNLKAsLENsLR
P06733 Y44 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 LFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKGVSK
P07195 S162 Sugiyama LDHB DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195 T302 Sugiyama LDHB YGIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsAD
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07205 S393 Sugiyama PGK2 PGKB GGDTATCCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEA
P07205 S399 Sugiyama PGK2 PGKB CCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEALSNM__
P07205 T394 Sugiyama PGK2 PGKB GDTATCCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEAL
P07814 S882 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 AQYKEKTGKEyIPGQPPLsQssDssPtRNsEPAGLEtPEAK
P07900 S53 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDsG
P07900 S63 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IFLRELIsNssDALDKIRyEsLtDPsKLDsGKELHINLIPN
P07900 T317 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA WtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P08238 S460 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB GIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQ
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 S48 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKLDsG
P08238 S58 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IFLRELIsNAsDALDKIRyEsLtDPsKLDsGKELKIDIIPN
P08238 T309 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB WtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P08238 T85 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB LDsGKELKIDIIPNPQERtLtLVDtGIGMtKADLINNLGtI
P08238 T94 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DIIPNPQERtLtLVDtGIGMtKADLINNLGtIAKSGtKAFM
P08238 Y301 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB ELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHF
P08238 Y305 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB tKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEG
P08670 S325 Sugiyama VIM NNDALRQAKQESTEYRRQVQsLtCEVDALKGtNEsLERQMR
P08758 T8 Sugiyama ANXA5 ANX5 ENX2 PP4 _____________MAQVLRGtVtDFPGFDERADAEtLRKAM
P0DJD0 S964 Sugiyama RGPD1 RANBP2L6 RGP1 GVIFGQTSSTFTFADVAKstsGEGFQFGKKDPNFKGFSGAG
P10412 S55 Sugiyama H1-4 H1F4 HIST1H1E AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P10412 S58 Sugiyama H1-4 H1F4 HIST1H1E PPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEKNNS
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11142 T163 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11142 T226 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11142 T45 Sugiyama HSPA8 HSC70 HSP73 HSPA10 KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPtN
P11142 T66 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQsD
P11142 Y41 Sugiyama HSPA8 HSC70 HSP73 HSPA10 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P12277 Y125 Sugiyama CKB CKBB EHKTDLNPDNLQGGDDLDPNyVLssRVRTGRSIRGFCLPPH
P13667 T380 Sugiyama PDIA4 ERP70 ERP72 PEKFQSKYEPRSHMMDVQGstQDsAIKDFVLKyALPLVGHR
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14314 S126 Sugiyama PRKCSH G19P1 yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14618 S55 Sugiyama PKM OIP3 PK2 PK3 PKM2 IDsPPItARNtGIICtIGPAsRsVEtLKEMIKsGMNVARLN
P14625 S109 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 IINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENALSGN
P14625 S172 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 VGMtREELVKNLGTIAKsGtsEFLNKMTEAQEDGQSTSELI
P14625 S551 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 MKEKQDKIyFMAGsSRKEAEssPFVERLLKKGyEVIyLTEP
P14625 T171 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 GVGMtREELVKNLGTIAKsGtsEFLNKMTEAQEDGQSTSEL
P16402 S56 Sugiyama H1-3 H1F3 HIST1H1D AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16402 S59 Sugiyama H1-3 H1F3 HIST1H1D PPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEKNNS
P16403 S55 Sugiyama H1-2 H1F2 HIST1H1C AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16403 S58 Sugiyama H1-2 H1F2 HIST1H1C PPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEKNNS
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17066 T47 Sugiyama HSPA6 HSP70B' RVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHN
P17066 Y43 Sugiyama HSPA6 HSP70B' FQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAAL
P18124 T17 Sugiyama RPL7 ____MEGVEEKKKEVPAVPEtLKKKRRNFAELKIKRLRKKF
P18621 S5 Sugiyama RPL17 ________________MVRysLDPENPtKsCKSRGSNLRVH
P19338 S328 Sugiyama NCL NLFVGNLNFNKSAPELKtGIsDVFAKNDLAVVDVRIGMTRK
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P22090 S204 Sugiyama RPS4Y1 RPS4Y PRO2646 IGGANLGRVGVITNRERHPGsFDVVHVKDANGNSFATRLSN
P22626 S344 Sugiyama HNRNPA2B1 HNRPA2B1 sRNMGGPyGGGNyGPGGsGGsGGyGGRsRy___________
P25398 S107 Sugiyama RPS12 EWVGLCKIDREGKPRKVVGCsCVVVKDYGKESQAKDVIEEy
P25789 T10 Sugiyama PSMA4 HC9 PSC9 ___________MSRRyDsRttIFsPEGRLYQVEYAMEAIGH
P26232 S667 Sugiyama CTNNA2 CAPR YDVRsRtsVQtEDDQLIAGQsARAIMAQLPQEEKAKIAEQV
P26373 S181 Sugiyama RPL13 BBC1 OK/SW-cl.46 YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P27348 S45 Sugiyama YWHAQ CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P27797 S52 Sugiyama CALR CRTC GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P27797 T34 Sugiyama CALR CRTC LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P29323 Y596 Sugiyama EPHB2 DRT EPHT3 EPTH3 ERK HEK5 TYRO5 EytDKLQHytsGHMTPGMKIyIDPFtyEDPNEAVREFAKEI
P29323 Y602 Sugiyama EPHB2 DRT EPHT3 EPTH3 ERK HEK5 TYRO5 QHytsGHMTPGMKIyIDPFtyEDPNEAVREFAKEIDISCVK
P29401 S443 Sugiyama TKT EDGPSQMALEDLAMFRsVPtstVFyPsDGVAtEKAVELAAN
P29401 T444 Sugiyama TKT DGPSQMALEDLAMFRsVPtstVFyPsDGVAtEKAVELAANT
P29692 S162 Sugiyama EEF1D EF1D AKKPAtPAEDDEDDDIDLFGsDNEEEDKEAAQLREERLRQY
P29692 S64 Sugiyama EEF1D EF1D sVILRDIARARENIQKsLAGssGPGAssGtsGDHGELVVRI
P29692 S65 Sugiyama EEF1D EF1D VILRDIARARENIQKsLAGssGPGAssGtsGDHGELVVRIA
P30050 S138 Sugiyama RPL12 HRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDINsG
P30086 S52 Sugiyama PEBP1 PBP PEBP AAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPD
P31327 T45 Sugiyama CPS1 AHQKWKFSRPGIRLLSVKAQtAHIVLEDGtKMKGYSFGHPS
P31946 S47 Sugiyama YWHAB AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31947 S45 Sugiyama SFN HME1 FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P34931 T47 Sugiyama HSPA1L KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPQN
P34931 Y43 Sugiyama HSPA1L FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P35221 S668 Sugiyama CTNNA1 FDVRsRtsVQtEDDQLIAGQsARAIMAQLPQEQKAKIAEQV
P35579 S1916 Sugiyama MYH9 LQRELEDAtEtADAMNREVssLKNKLRRGDLPFVVPRRMAR
P35613 S279 Sugiyama BSG UNQ6505/PRO21383 TDSEDKALMNGSESRFFVsssQGRSELHIENLNMEADPGQy
P37802 S185 Sugiyama TAGLN2 KIAA0120 CDABP0035 NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P37802 T180 Sugiyama TAGLN2 KIAA0120 CDABP0035 RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P37802 T190 Sugiyama TAGLN2 KIAA0120 CDABP0035 GKNVIGLQMGtNRGAsQAGMtGyGMPRQIL___________
P38646 S89 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P38646 T111 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VAFtADGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDP
P38646 T398 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 SDIGEVILVGGMTRMPKVQQtVQDLFGRAPsKAVNPDEAVA
P39019 Y48 Sugiyama RPS19 LKVPEWVDtVKLAKHKELAPyDENWFytRAAstARHLYLRG
P39019 Y54 Sugiyama RPS19 VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P39023 S265 Sugiyama RPL3 OK/SW-cl.32 HRGLRKVACIGAWHPARVAFsVARAGQKGYHHRTEINKKIY
P40818 S719 Sugiyama USP8 KIAA0055 UBPY KPQIPAERDREPSKLKRsyssPDItQAIQEEEKRKPTVtPT
P42677 S78 Sugiyama RPS27 MPS1 GCSTVLCQPTGGKARLtEGCsFRRKQH______________
P46013 S651 Sugiyama MKI67 ISRsQHDILQMICSKRRsGAsEANLIVAKSWADVVKLGAKQ
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46777 S176 Sugiyama RPL5 MSTP030 GNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHR
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46777 T177 Sugiyama RPL5 MSTP030 NKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHRK
P46783 S146 Sugiyama RPS10 TYRRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ_
P47712 S729 Sugiyama PLA2G4A CPLA2 PLA2G4 KEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKPKA
P47914 S142 Sugiyama RPL29 KAKAKAKAKDQTKAQAAAPAsVPAQAPKRtQAPtKAsE___
P48643 S270 Sugiyama CCT5 CCTE KIAA0098 ILTCPFEPPKPKTKHKLDVtsVEDyKALQKYEKEKFEEMIQ
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P48741 T47 Sugiyama HSPA7 HSP70B RVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHN
P48741 Y43 Sugiyama HSPA7 HSP70B FQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAAL
P49327 T2215 Sugiyama FASN FAS DEAsELACPtPKEDGLAQQQtQLNLRSLLVNPEGPtLMRLN
P49368 T254 Sugiyama CCT3 CCTG TRIC5 KNPRIVLLDssLEyKKGEsQtDIEITREEDFTRILQMEEEY
P49792 S1955 Sugiyama RANBP2 NUP358 GVIFGQTSSTFTFADLAKstsGEGFQFGKKDPNFKGFSGAG
P49840 Y279 Sugiyama GSK3A LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P49841 Y216 Sugiyama GSK3B LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P50395 S396 Sugiyama GDI2 RABGDIB IEQKFVsISDLLVPKDLGtEsQIFIsRTyDAttHFEttCDD
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P54652 T229 Sugiyama HSPA2 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P54652 T46 Sugiyama HSPA2 KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPTN
P54652 Y42 Sugiyama HSPA2 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P54762 Y594 Sugiyama EPHB1 ELK EPHT2 HEK6 NET VYSDKLQHYSTGRGsPGMKIyIDPFtyEDPNEAVREFAKEI
P54762 Y600 Sugiyama EPHB1 ELK EPHT2 HEK6 NET QHYSTGRGsPGMKIyIDPFtyEDPNEAVREFAKEIDVSFVK
P60174 S106 Sugiyama TPI1 TPI DCGAtWVVLGHsERRHVFGEsDELIGQKVAHALAEGLGVIA
P60174 T217 Sugiyama TPI1 TPI VsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGGAsL
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709 S323 Sugiyama ACTB ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709 S60 Sugiyama ACTB HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P60709 T249 Sugiyama ACTB tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM
P60709 T297 Sugiyama ACTB TTFNSIMKCDVDIRKDLyANtVLsGGttMyPGIADRMQKEI
P60709 T304 Sugiyama ACTB KCDVDIRKDLyANtVLsGGttMyPGIADRMQKEItALAPst
P60709 T324 Sugiyama ACTB tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P60709 Y53 Sugiyama ACTB sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P61081 S175 Sugiyama UBE2M UBC12 NNRRLFEQNVQRSMRGGyIGstyFERCLK____________
P61981 S46 Sugiyama YWHAG AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P62241 S160 Sugiyama RPS8 OK/SW-cl.83 KRSKKIQKKYDERKKNAKIssLLEEQFQQGKLLACIASRPG
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S46 Sugiyama YWHAE SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62701 S204 Sugiyama RPS4X CCG2 RPS4 SCAR tGGANLGRIGVITNRERHPGsFDVVHVKDANGNSFATRLsN
P62736 S325 Sugiyama ACTA2 ACTSA ACTVS GIG46 tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736 S62 Sugiyama ACTA2 ACTSA ACTVS GIG46 HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P62736 T251 Sugiyama ACTA2 ACTSA ACTVS GIG46 tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P62736 T326 Sugiyama ACTA2 ACTSA ACTVS GIG46 TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62736 Y55 Sugiyama ACTA2 ACTSA ACTVS GIG46 sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P62899 S15 Sugiyama RPL31 ______MAPAKKGGEKKKGRsAINEVVtREytINIHKRIHG
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917 T146 Sugiyama RPL8 LARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVISSANRAVV
P62942 T22 Sugiyama FKBP1A FKBP1 FKBP12 GVQVEtIsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRD
P62942 T28 Sugiyama FKBP1A FKBP1 FKBP12 IsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRDRNKPFK
P62942 T7 Sugiyama FKBP1A FKBP1 FKBP12 ______________MGVQVEtIsPGDGRtFPKRGQtCVVHy
P63104 S45 Sugiyama YWHAZ CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
P63220 S65 Sugiyama RPS21 RFNGQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF__
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261 S323 Sugiyama ACTG1 ACTG ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261 S60 Sugiyama ACTG1 ACTG HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P63261 T249 Sugiyama ACTG1 ACTG tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM
P63261 T297 Sugiyama ACTG1 ACTG TTFNSIMKCDVDIRKDLyANtVLsGGttMyPGIADRMQKEI
P63261 T304 Sugiyama ACTG1 ACTG KCDVDIRKDLyANtVLsGGttMyPGIADRMQKEItALAPst
P63261 T324 Sugiyama ACTG1 ACTG tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63261 Y53 Sugiyama ACTG1 ACTG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267 S324 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267 S61 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P63267 T250 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P63267 T325 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P63267 Y54 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68032 S325 Sugiyama ACTC1 ACTC tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032 S62 Sugiyama ACTC1 ACTC HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68032 T251 Sugiyama ACTC1 ACTC tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P68032 T326 Sugiyama ACTC1 ACTC TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68032 Y55 Sugiyama ACTC1 ACTC sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68104 T432 Sugiyama EEF1A1 EEF1A EF1A LENG7 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
P68133 S325 Sugiyama ACTA1 ACTA TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133 S62 Sugiyama ACTA1 ACTA HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68133 T251 Sugiyama ACTA1 ACTA tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P68133 T326 Sugiyama ACTA1 ACTA TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68133 Y55 Sugiyama ACTA1 ACTA sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68363 T73 Sugiyama TUBA1B FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
P68363 T82 Sugiyama TUBA1B VPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANN
P68363 Y432 Sugiyama TUBA1B GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
P83731 S38 Sugiyama RPL24 GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P83731 S86 Sugiyama RPL24 EIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKAQRE
P83731 T83 Sugiyama RPL24 QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
Q00839 Y260 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 GDKKRGVKRPREDHGRGyFEyIEENKysRAKsPQPPVEEED
Q01105 S161 Sugiyama SET FDENPyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTK
Q01105 S166 Sugiyama SET yFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQT
Q01105 S168 Sugiyama SET ENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQN
Q01105 T169 Sugiyama SET NKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQNK
Q04917 S46 Sugiyama YWHAH YWHA1 AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q05639 T432 Sugiyama EEF1A2 EEF1AL STN VESFSQYPPLGRFAVRDMRQtVAVGVIKNVEKKSGGAGKVT
Q07020 T136 Sugiyama RPL18 AGGKILtFDQLALDsPKGCGtVLLsGPRKGREVYRHFGKAP
Q07020 T85 Sugiyama RPL18 RMIRKMKLPGRENKtAVVVGtItDDVRVQEVPKLKVCALRV
Q09028 S147 Sugiyama RBBP4 RBAP48 VNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGEC
Q12965 S980 Sugiyama MYO1E MYO1C GyHQNGVIRNQyVPYPHAPGsQRSNQKSLyTsMARPPLPRQ
Q13283 S67 Sugiyama G3BP1 G3BP sNGKPADAVyGQKEIHRKVMsQNFtNCHTKIRHVDAHATLN
Q14152 S988 Sugiyama EIF3A EIF3S10 KIAA0139 PRRGPEEDRFsRRGADDDRPsWRNTDDDRPPRRIADEDRGN
Q14568 S53 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 IINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDSG
Q15080 S67 Sugiyama NCF4 SH3PXD4 TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q15185 S82 Sugiyama PTGES3 P23 TEBP NDsKHKRtDRsILCCLRKGEsGQsWPRLTKERAKLNWLsVD
Q16576 S146 Sugiyama RBBP7 RBAP46 VNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGEC
Q562R1 T250 Sugiyama ACTBL2 RAAAssSPERsyELPDGQVItIGNERFRCPEAIFQPSFLGI
Q58FF6 S34 Sugiyama HSP90AB4P IFLQELISNASDALDKIRyEsLtDPsKLDGGKELKIDIIPN
Q58FF7 S58 Sugiyama HSP90AB3P HSP90BC IFLQELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q58FF8 S58 Sugiyama HSP90AB2P HSP90BB IFLWELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q5SSJ5 S323 Sugiyama HP1BP3 NALQRAVERGQLEQITGKGAsGTFQLKKSGEKPLLGGSLME
Q5VTE0 T432 Sugiyama EEF1A1P5 EEF1AL3 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
Q6PCE3 S175 Sugiyama PGM2L1 BM32A PFVPYAVQKLKAVAGVMItAsHNRKEDNGYKVYWETGAQIT
Q6S8J3 T949 Sugiyama POTEE A26C1A POTE2 tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
Q71U36 T73 Sugiyama TUBA1A TUBA3 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q71U36 T82 Sugiyama TUBA1A TUBA3 VPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANN
Q71U36 Y432 Sugiyama TUBA1A TUBA3 GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q71UM5 S78 Sugiyama RPS27L GCSTVLCQPTGGKARLtEGCsFRRKQH______________
Q7Z3J3 S980 Sugiyama RGPD4 RGP4 GVIFGQTSSTFTFADVAKstsGEGFQFGKKDPNFKGFSGAG
Q86V81 S145 Sugiyama ALYREF ALY BEF THOC4 LFAEFGtLKKAAVHYDRsGRsLGtADVHFERKADALKAMKQ
Q86VQ1 S223 Sugiyama GLCCI1 QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q8NBJ7 S256 Sugiyama SUMF2 PSEC0171 UNQ1968/PRO4500 EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG
Q99666 S979 Sugiyama RGPD5 RANBP2L1 RGP5 RGP7 RGPD7; RGPD6 RANBP2L2 RGP6 GVIFGQTSSTFTFADVAKstsGEGFQFGKKDLNFKGFSGAG
Q99832 S59 Sugiyama CCT7 CCTH NIP7-1 TLGPRGMDKLIVDGRGKAtIsNDGAtILKLLDVVHPAAKTL
Q9BQE3 T73 Sugiyama TUBA1C TUBA6 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q9BQE3 T82 Sugiyama TUBA1C TUBA6 VPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANN
Q9BYP7 S289 Sugiyama WNK3 KIAA1566 PRKWNK3 PPIIHRDLKCDNIFItGPtGsVKIGDLGLATLMRtsFAKsV
Q9BYP7 T284 Sugiyama WNK3 KIAA1566 PRKWNK3 LHTRTPPIIHRDLKCDNIFItGPtGsVKIGDLGLATLMRts
Q9BYP7 T287 Sugiyama WNK3 KIAA1566 PRKWNK3 RTPPIIHRDLKCDNIFItGPtGsVKIGDLGLATLMRtsFAK
Q9BYX7 T249 Sugiyama POTEKP ACTBL3 FKSG30 MAASSSSVEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
Q9H173 T125 Sugiyama SIL1 UNQ545/PRO836 QYEDKFRNNLKGKRLDINtNtytsQDLKSALAKFKEGAEME
Q9H4A3 S2372 Sugiyama WNK1 HSN2 KDP KIAA0344 PRKWNK1 QPVGTASLQNFNISNLQKsIsNPPGSNLRTT__________
Q9H4A3 S363 Sugiyama WNK1 HSN2 KDP KIAA0344 PRKWNK1 PPIIHRDLKCDNIFItGPtGsVKIGDLGLATLKRAsFAKsV
Q9H4A3 S382 SIGNOR|EPSD|PSP WNK1 HSN2 KDP KIAA0344 PRKWNK1 GsVKIGDLGLATLKRAsFAKsVIGtPEFMAPEMYEEKYDES
Q9H4A3 T358 Sugiyama WNK1 HSN2 KDP KIAA0344 PRKWNK1 LHTRTPPIIHRDLKCDNIFItGPtGsVKIGDLGLATLKRAs
Q9H4A3 T361 Sugiyama WNK1 HSN2 KDP KIAA0344 PRKWNK1 RTPPIIHRDLKCDNIFItGPtGsVKIGDLGLATLKRAsFAK
Q9NQ39 S157 Sugiyama RPS10P5 RPS10L TYRRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ_
Q9UEW8 S371 EPSD|PSP STK39 PASK SPAK LtRtPDIAQRAKKVRRVPGssGHLHKTEDGDWEWsDDEMDE
Q9UEW8 T354 EPSD|PSP STK39 PASK SPAK CKFFQKAKNREYLIEKLLtRtPDIAQRAKKVRRVPGssGHL
Q9UI15 S185 Sugiyama TAGLN3 NP25 EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UI15 T190 Sugiyama TAGLN3 NP25 GQNVIGLQMGSNKGAsQAGMtGyGMPRQIM___________
Q9Y2B0 S115 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 QIDPstHRKNYVRVVGRNGEssELDLQGIRIDsDISGtLKF
Q9Y3S1 S337 Sugiyama WNK2 KIAA1760 PRKWNK2 SDCCAG43 P/OKcl.13 PPIIHRDLKCDNIFItGPtGsVKIGDLGLATLKRAsFAKSV
Q9Y3S1 S472 Sugiyama WNK2 KIAA1760 PRKWNK2 SDCCAG43 P/OKcl.13 FFAEDTGVRVELAEEDHGRKstIALRLWVEDPKKLKGKPKD
Q9Y3S1 T332 Sugiyama WNK2 KIAA1760 PRKWNK2 SDCCAG43 P/OKcl.13 LHTRTPPIIHRDLKCDNIFItGPtGsVKIGDLGLATLKRAs
Q9Y3S1 T335 Sugiyama WNK2 KIAA1760 PRKWNK2 SDCCAG43 P/OKcl.13 RTPPIIHRDLKCDNIFItGPtGsVKIGDLGLATLKRAsFAK
Q9Y3S1 T473 Sugiyama WNK2 KIAA1760 PRKWNK2 SDCCAG43 P/OKcl.13 FAEDTGVRVELAEEDHGRKstIALRLWVEDPKKLKGKPKDN
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cellular response to heat stress R-HSA-3371556 1.110223e-16 15.955 0 0
Cell Cycle, Mitotic R-HSA-69278 1.110223e-16 15.955 0 0
Cell Cycle R-HSA-1640170 1.110223e-16 15.955 0 0
M Phase R-HSA-68886 1.110223e-16 15.955 0 0
Axon guidance R-HSA-422475 1.110223e-16 15.955 0 0
Signaling by ROBO receptors R-HSA-376176 1.110223e-16 15.955 0 0
Nervous system development R-HSA-9675108 1.110223e-16 15.955 0 0
Cellular responses to stimuli R-HSA-8953897 1.110223e-16 15.955 0 0
Cellular responses to stress R-HSA-2262752 1.110223e-16 15.955 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 4.440892e-16 15.353 0 0
Eukaryotic Translation Initiation R-HSA-72613 8.881784e-16 15.051 0 0
Cap-dependent Translation Initiation R-HSA-72737 8.881784e-16 15.051 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.554312e-15 14.808 0 0
Mitotic Anaphase R-HSA-68882 4.107825e-15 14.386 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 5.107026e-15 14.292 0 0
Mitotic Prometaphase R-HSA-68877 9.658940e-15 14.015 0 0
Metabolism of RNA R-HSA-8953854 9.547918e-15 14.020 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 3.252953e-14 13.488 0 0
Eukaryotic Translation Elongation R-HSA-156842 3.852474e-14 13.414 0 0
Separation of Sister Chromatids R-HSA-2467813 1.296740e-13 12.887 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 3.960166e-13 12.402 0 0
Cell-Cell communication R-HSA-1500931 5.759837e-13 12.240 0 0
Apoptosis R-HSA-109581 7.004397e-13 12.155 0 0
Cell Cycle Checkpoints R-HSA-69620 1.020517e-12 11.991 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.663003e-12 11.779 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.841638e-12 11.735 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.993072e-12 11.700 0 0
Apoptotic execution phase R-HSA-75153 2.130518e-12 11.672 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 4.306555e-12 11.366 0 0
HSF1-dependent transactivation R-HSA-3371571 4.398371e-12 11.357 0 0
Peptide chain elongation R-HSA-156902 5.305645e-12 11.275 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 5.270007e-12 11.278 0 0
Ribosome-associated quality control R-HSA-9948299 1.036882e-11 10.984 0 0
Programmed Cell Death R-HSA-5357801 2.271017e-11 10.644 0 0
Influenza Infection R-HSA-168255 3.550049e-11 10.450 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 4.776624e-11 10.321 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 6.111167e-11 10.214 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 6.491552e-11 10.188 0 0
Translation initiation complex formation R-HSA-72649 6.786705e-11 10.168 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 6.900069e-11 10.161 0 0
Recycling pathway of L1 R-HSA-437239 7.280898e-11 10.138 0 0
Cell junction organization R-HSA-446728 7.194234e-11 10.143 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 7.678780e-11 10.115 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 8.043410e-11 10.095 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 9.285828e-11 10.032 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.004925e-10 9.998 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.004925e-10 9.998 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.074223e-10 9.969 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.474872e-10 9.831 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.974551e-10 9.705 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 2.068249e-10 9.684 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 2.671334e-10 9.573 0 0
Signal Transduction R-HSA-162582 3.457253e-10 9.461 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 3.849334e-10 9.415 0 0
L1CAM interactions R-HSA-373760 4.493401e-10 9.347 0 0
Post NMDA receptor activation events R-HSA-438064 5.780425e-10 9.238 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 6.968290e-10 9.157 0 0
Eukaryotic Translation Termination R-HSA-72764 8.619072e-10 9.065 0 0
Developmental Biology R-HSA-1266738 8.941325e-10 9.049 0 0
Attenuation phase R-HSA-3371568 9.746547e-10 9.011 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.287600e-09 8.890 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.287600e-09 8.890 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.932692e-09 8.714 0 0
EPH-Ephrin signaling R-HSA-2682334 2.989409e-09 8.524 0 0
HSF1 activation R-HSA-3371511 3.563957e-09 8.448 0 0
Selenocysteine synthesis R-HSA-2408557 4.003698e-09 8.398 0 0
Cellular Senescence R-HSA-2559583 4.575127e-09 8.340 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 4.680657e-09 8.330 0 0
Viral mRNA Translation R-HSA-192823 6.504121e-09 8.187 0 0
PKR-mediated signaling R-HSA-9833482 7.223997e-09 8.141 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 8.280370e-09 8.082 0 0
Cytokine Signaling in Immune system R-HSA-1280215 8.379966e-09 8.077 0 0
Mitotic Prophase R-HSA-68875 9.170201e-09 8.038 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.208944e-08 7.918 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.463439e-08 7.608 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 2.475350e-08 7.606 0 0
rRNA processing R-HSA-72312 2.706173e-08 7.568 0 0
Adherens junctions interactions R-HSA-418990 3.688423e-08 7.433 0 0
Cell-cell junction organization R-HSA-421270 3.963840e-08 7.402 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 4.173319e-08 7.380 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 4.329892e-08 7.364 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 6.096828e-08 7.215 0 0
G2/M Transition R-HSA-69275 6.920203e-08 7.160 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 7.304849e-08 7.136 0 0
Aggrephagy R-HSA-9646399 7.738256e-08 7.111 0 0
Mitotic G2-G2/M phases R-HSA-453274 9.456290e-08 7.024 0 0
Cellular response to starvation R-HSA-9711097 9.822424e-08 7.008 0 0
Membrane Trafficking R-HSA-199991 1.293050e-07 6.888 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.376923e-07 6.861 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.945050e-07 6.711 0 0
Selective autophagy R-HSA-9663891 2.174566e-07 6.663 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 2.505176e-07 6.601 0 0
SARS-CoV-2-host interactions R-HSA-9705683 3.236473e-07 6.490 0 0
SARS-CoV-1 Infection R-HSA-9678108 3.317292e-07 6.479 0 0
Interferon Signaling R-HSA-913531 3.496605e-07 6.456 0 0
Macroautophagy R-HSA-1632852 3.580492e-07 6.446 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 4.223738e-07 6.374 0 0
Signaling by ALK in cancer R-HSA-9700206 4.223738e-07 6.374 0 0
Transport of connexons to the plasma membrane R-HSA-190872 4.344484e-07 6.362 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 5.554144e-07 6.255 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 5.719246e-07 6.243 0 0
Signaling by RAF1 mutants R-HSA-9656223 6.053688e-07 6.218 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 6.436220e-07 6.191 0 0
Signaling by RAS mutants R-HSA-6802949 8.234275e-07 6.084 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 8.234275e-07 6.084 0 0
Signaling downstream of RAS mutants R-HSA-9649948 8.234275e-07 6.084 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 8.234275e-07 6.084 0 0
Oncogene Induced Senescence R-HSA-2559585 7.995100e-07 6.097 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 8.836016e-07 6.054 0 0
Autophagy R-HSA-9612973 8.943073e-07 6.049 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 8.964801e-07 6.047 0 0
Amplification of signal from the kinetochores R-HSA-141424 8.964801e-07 6.047 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 9.591610e-07 6.018 0 0
MAPK family signaling cascades R-HSA-5683057 1.025492e-06 5.989 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.038253e-06 5.984 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 1.202965e-06 5.920 0 0
Glycolysis R-HSA-70171 1.556916e-06 5.808 0 0
Regulation of CDH1 Function R-HSA-9764561 1.703345e-06 5.769 0 0
Viral Infection Pathways R-HSA-9824446 1.788864e-06 5.747 0 0
Protein folding R-HSA-391251 1.790285e-06 5.747 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 2.203649e-06 5.657 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 3.151920e-06 5.501 0 0
Intracellular signaling by second messengers R-HSA-9006925 3.732361e-06 5.428 0 0
Chaperonin-mediated protein folding R-HSA-390466 3.755452e-06 5.425 0 0
Mitotic Spindle Checkpoint R-HSA-69618 3.995463e-06 5.398 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 4.153302e-06 5.382 0 0
G2/M Checkpoints R-HSA-69481 4.318836e-06 5.365 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 4.566283e-06 5.340 0 0
mRNA Splicing - Major Pathway R-HSA-72163 4.766479e-06 5.322 0 0
Nuclear Envelope Breakdown R-HSA-2980766 5.322306e-06 5.274 0 0
Oncogenic MAPK signaling R-HSA-6802957 5.441312e-06 5.264 0 0
UCH proteinases R-HSA-5689603 6.110670e-06 5.214 0 0
Gap junction trafficking and regulation R-HSA-157858 6.564345e-06 5.183 0 0
Signaling by Hippo R-HSA-2028269 7.095864e-06 5.149 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 7.135530e-06 5.147 0 0
Cell-extracellular matrix interactions R-HSA-446353 8.236882e-06 5.084 0 0
mRNA Splicing R-HSA-72172 9.303309e-06 5.031 0 0
Ephrin signaling R-HSA-3928664 1.127507e-05 4.948 0 0
Host Interactions of HIV factors R-HSA-162909 1.209801e-05 4.917 0 0
Translation R-HSA-72766 1.336152e-05 4.874 0 0
Selenoamino acid metabolism R-HSA-2408522 1.340602e-05 4.873 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.502357e-05 4.823 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.429310e-05 4.845 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.436568e-05 4.843 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 1.510735e-05 4.821 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.554856e-05 4.808 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.587205e-05 4.799 0 0
Gap junction trafficking R-HSA-190828 1.770017e-05 4.752 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.905283e-05 4.720 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.960751e-05 4.708 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 2.072495e-05 4.684 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 2.181481e-05 4.661 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 2.181481e-05 4.661 0 0
Signaling by PTK6 R-HSA-8848021 2.181481e-05 4.661 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 2.181481e-05 4.661 0 0
Semaphorin interactions R-HSA-373755 2.181481e-05 4.661 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 2.060437e-05 4.686 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 2.060437e-05 4.686 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 2.181481e-05 4.661 0 0
Interleukin-12 family signaling R-HSA-447115 2.514066e-05 4.600 0 0
ESR-mediated signaling R-HSA-8939211 2.824187e-05 4.549 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 2.919328e-05 4.535 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 3.060542e-05 4.514 0 0
Kinesins R-HSA-983189 3.169303e-05 4.499 0 0
HIV Infection R-HSA-162906 3.406062e-05 4.468 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 3.496140e-05 4.456 0 0
Interleukin-12 signaling R-HSA-9020591 4.345147e-05 4.362 0 0
Glucose metabolism R-HSA-70326 4.720243e-05 4.326 0 0
HCMV Early Events R-HSA-9609690 4.739129e-05 4.324 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 4.878899e-05 4.312 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 5.111486e-05 4.291 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 5.195188e-05 4.284 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 5.243087e-05 4.280 0 0
Folding of actin by CCT/TriC R-HSA-390450 5.436491e-05 4.265 0 0
EPHB-mediated forward signaling R-HSA-3928662 5.542672e-05 4.256 0 0
Hedgehog 'off' state R-HSA-5610787 5.683805e-05 4.245 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 5.732846e-05 4.242 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 6.298885e-05 4.201 0 0
PTEN Regulation R-HSA-6807070 7.286839e-05 4.137 0 0
RAF/MAP kinase cascade R-HSA-5673001 7.422803e-05 4.129 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 7.505334e-05 4.125 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 8.019688e-05 4.096 0 0
MAP2K and MAPK activation R-HSA-5674135 8.034838e-05 4.095 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 8.263333e-05 4.083 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 8.341922e-05 4.079 0 0
Signaling by ERBB2 R-HSA-1227986 8.742537e-05 4.058 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 8.742537e-05 4.058 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 9.122891e-05 4.040 0 0
Centrosome maturation R-HSA-380287 9.156205e-05 4.038 0 0
Signaling by Interleukins R-HSA-449147 9.391237e-05 4.027 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 9.889866e-05 4.005 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 9.993151e-05 4.000 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.018424e-04 3.992 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.165132e-04 3.934 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.163766e-04 3.934 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.163700e-04 3.934 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.258547e-04 3.900 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.301827e-04 3.885 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.495678e-04 3.825 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 1.577954e-04 3.802 0 0
Deubiquitination R-HSA-5688426 1.646164e-04 3.784 0 0
RMTs methylate histone arginines R-HSA-3214858 1.652323e-04 3.782 0 0
G1/S Transition R-HSA-69206 1.655054e-04 3.781 0 0
Signaling by VEGF R-HSA-194138 1.655054e-04 3.781 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.690097e-04 3.772 0 0
SARS-CoV-2 Infection R-HSA-9694516 1.734995e-04 3.761 0 0
Diseases of programmed cell death R-HSA-9645723 1.735954e-04 3.760 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.981615e-04 3.703 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.881799e-04 3.725 0 0
FLT3 Signaling R-HSA-9607240 1.905412e-04 3.720 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.903173e-04 3.721 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.981615e-04 3.703 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.943527e-04 3.711 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.981615e-04 3.703 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 2.055299e-04 3.687 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 2.175426e-04 3.662 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.193599e-04 3.659 0 0
Gene expression (Transcription) R-HSA-74160 2.346454e-04 3.630 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 2.452331e-04 3.610 0 0
Neutrophil degranulation R-HSA-6798695 2.658604e-04 3.575 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 2.719215e-04 3.566 0 0
Clathrin-mediated endocytosis R-HSA-8856828 2.723664e-04 3.565 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.781705e-04 3.556 0 0
Vesicle-mediated transport R-HSA-5653656 2.900596e-04 3.538 0 0
Metalloprotease DUBs R-HSA-5689901 2.949602e-04 3.530 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 3.026205e-04 3.519 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 3.041447e-04 3.517 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 3.053314e-04 3.515 0 0
Cilium Assembly R-HSA-5617833 3.066771e-04 3.513 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 3.105060e-04 3.508 0 0
DNA Double Strand Break Response R-HSA-5693606 3.324814e-04 3.478 0 0
mTORC1-mediated signalling R-HSA-166208 3.104487e-04 3.508 0 0
Nuclear import of Rev protein R-HSA-180746 3.166281e-04 3.499 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 3.518031e-04 3.454 0 0
Stabilization of p53 R-HSA-69541 3.518031e-04 3.454 0 0
COPI-mediated anterograde transport R-HSA-6807878 3.522684e-04 3.453 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 3.518031e-04 3.454 0 0
Gap junction assembly R-HSA-190861 3.166281e-04 3.499 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 3.522684e-04 3.453 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 3.899761e-04 3.409 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 3.927008e-04 3.406 0 0
Gene Silencing by RNA R-HSA-211000 4.061204e-04 3.391 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 4.062368e-04 3.391 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 4.223829e-04 3.374 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 4.311213e-04 3.365 0 0
Negative regulation of MET activity R-HSA-6807004 4.382491e-04 3.358 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 4.475164e-04 3.349 0 0
Co-inhibition by PD-1 R-HSA-389948 4.530518e-04 3.344 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 4.638452e-04 3.334 0 0
MHC class II antigen presentation R-HSA-2132295 4.708968e-04 3.327 0 0
Degradation of CDH1 R-HSA-9766229 4.830641e-04 3.316 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 4.901948e-04 3.310 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 4.951138e-04 3.305 0 0
RNA Polymerase II Transcription R-HSA-73857 5.039484e-04 3.298 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 5.250857e-04 3.280 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 5.316204e-04 3.274 0 0
Nucleosome assembly R-HSA-774815 5.762621e-04 3.239 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 5.762621e-04 3.239 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 5.899218e-04 3.229 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 6.535433e-04 3.185 0 0
HIV Life Cycle R-HSA-162587 6.701144e-04 3.174 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 6.845171e-04 3.165 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 6.845171e-04 3.165 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 6.845171e-04 3.165 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 7.708178e-04 3.113 0 0
Signaling by PDGFR in disease R-HSA-9671555 8.162813e-04 3.088 0 0
Sema4D in semaphorin signaling R-HSA-400685 7.500635e-04 3.125 0 0
Long-term potentiation R-HSA-9620244 7.500635e-04 3.125 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 7.526761e-04 3.123 0 0
Signaling by EGFR R-HSA-177929 7.093749e-04 3.149 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 7.093749e-04 3.149 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 8.162813e-04 3.088 0 0
SARS-CoV Infections R-HSA-9679506 7.924957e-04 3.101 0 0
MTOR signalling R-HSA-165159 8.430703e-04 3.074 0 0
Muscle contraction R-HSA-397014 8.493255e-04 3.071 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 8.507374e-04 3.070 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 8.507374e-04 3.070 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 8.589024e-04 3.066 0 0
mRNA 3'-end processing R-HSA-72187 8.595649e-04 3.066 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 8.655497e-04 3.063 0 0
Late Phase of HIV Life Cycle R-HSA-162599 8.940746e-04 3.049 0 0
S Phase R-HSA-69242 9.022443e-04 3.045 0 0
RAF activation R-HSA-5673000 9.489410e-04 3.023 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.489410e-04 3.023 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 9.655581e-04 3.015 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 9.739768e-04 3.011 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 9.807304e-04 3.008 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.002995e-03 2.999 0 0
Regulation of PTEN stability and activity R-HSA-8948751 1.031153e-03 2.987 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.031153e-03 2.987 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.033818e-03 2.986 0 0
Meiosis R-HSA-1500620 1.071044e-03 2.970 0 0
EGFR downregulation R-HSA-182971 1.103410e-03 2.957 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.103410e-03 2.957 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.103410e-03 2.957 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 1.103410e-03 2.957 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 1.143303e-03 2.942 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.158268e-03 2.936 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 1.231115e-03 2.910 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.235227e-03 2.908 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.235227e-03 2.908 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 1.255170e-03 2.901 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.285521e-03 2.891 0 0
Chromatin organization R-HSA-4839726 1.360103e-03 2.866 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.412709e-03 2.850 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.431889e-03 2.844 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 1.434378e-03 2.843 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.579176e-03 2.802 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 1.511076e-03 2.821 0 0
Regulation of RAS by GAPs R-HSA-5658442 1.499980e-03 2.824 0 0
HDACs deacetylate histones R-HSA-3214815 1.463098e-03 2.835 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.495542e-03 2.825 0 0
Nephrin family interactions R-HSA-373753 1.579176e-03 2.802 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.531864e-03 2.815 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 1.518003e-03 2.819 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 1.518003e-03 2.819 0 0
Regulation of TP53 Activity R-HSA-5633007 1.638956e-03 2.785 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.731060e-03 2.762 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.734141e-03 2.761 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.744261e-03 2.758 0 0
Meiotic recombination R-HSA-912446 1.788033e-03 2.748 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.812849e-03 2.742 0 0
Signaling by Hedgehog R-HSA-5358351 1.825996e-03 2.739 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.836708e-03 2.736 0 0
Chromatin modifying enzymes R-HSA-3247509 1.855748e-03 2.731 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 1.859100e-03 2.731 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.922099e-03 2.716 0 0
Ub-specific processing proteases R-HSA-5689880 1.931709e-03 2.714 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 2.092131e-03 2.679 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 2.092131e-03 2.679 0 0
Orc1 removal from chromatin R-HSA-68949 2.121197e-03 2.673 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 2.121197e-03 2.673 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 2.164988e-03 2.665 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.216549e-03 2.654 0 0
Ca-dependent events R-HSA-111996 2.218823e-03 2.654 0 0
G2/M DNA damage checkpoint R-HSA-69473 2.309406e-03 2.636 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 2.311822e-03 2.636 0 0
HCMV Infection R-HSA-9609646 2.370594e-03 2.625 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 2.413684e-03 2.617 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 2.504797e-03 2.601 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 2.504797e-03 2.601 0 0
Defective pyroptosis R-HSA-9710421 2.664663e-03 2.574 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 2.665760e-03 2.574 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 3.058513e-03 2.514 0 0
Formation of annular gap junctions R-HSA-196025 3.065343e-03 2.514 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 3.065343e-03 2.514 0 0
Cyclin D associated events in G1 R-HSA-69231 3.182005e-03 2.497 0 0
G1 Phase R-HSA-69236 3.182005e-03 2.497 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 3.182005e-03 2.497 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 3.247657e-03 2.488 0 0
Regulation of PTEN gene transcription R-HSA-8943724 3.253070e-03 2.488 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 3.257461e-03 2.487 0 0
Regulation of Apoptosis R-HSA-169911 3.257461e-03 2.487 0 0
Regulation of mitotic cell cycle R-HSA-453276 3.277227e-03 2.484 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 3.277227e-03 2.484 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 3.305949e-03 2.481 0 0
DCC mediated attractive signaling R-HSA-418885 3.305949e-03 2.481 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 3.331558e-03 2.477 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 3.367015e-03 2.473 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 3.367015e-03 2.473 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 3.446508e-03 2.463 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 3.803689e-03 2.420 0 0
Regulation of signaling by CBL R-HSA-912631 4.020654e-03 2.396 0 0
Interaction between L1 and Ankyrins R-HSA-445095 3.795864e-03 2.421 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 3.795864e-03 2.421 0 0
PRC2 methylates histones and DNA R-HSA-212300 3.951745e-03 2.403 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 4.017165e-03 2.396 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 4.356544e-03 2.361 0 0
CaM pathway R-HSA-111997 3.951745e-03 2.403 0 0
Calmodulin induced events R-HSA-111933 3.951745e-03 2.403 0 0
FLT3 signaling in disease R-HSA-9682385 3.951745e-03 2.403 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 3.803689e-03 2.420 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 3.894027e-03 2.410 0 0
Response of endothelial cells to shear stress R-HSA-9860931 4.010421e-03 2.397 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 3.669103e-03 2.435 0 0
PCP/CE pathway R-HSA-4086400 3.950535e-03 2.403 0 0
Signaling by WNT R-HSA-195721 4.352197e-03 2.361 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 3.845803e-03 2.415 0 0
Generic Transcription Pathway R-HSA-212436 4.329337e-03 2.364 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 3.795864e-03 2.421 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 3.928821e-03 2.406 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 3.771556e-03 2.423 0 0
HATs acetylate histones R-HSA-3214847 4.418009e-03 2.355 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 4.464923e-03 2.350 0 0
Regulation of TNFR1 signaling R-HSA-5357905 4.464923e-03 2.350 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 4.464923e-03 2.350 0 0
Prolonged ERK activation events R-HSA-169893 4.471958e-03 2.350 0 0
TCF dependent signaling in response to WNT R-HSA-201681 4.499482e-03 2.347 0 0
TCR signaling R-HSA-202403 4.500148e-03 2.347 0 0
DNA Double-Strand Break Repair R-HSA-5693532 4.621911e-03 2.335 0 0
Gap junction degradation R-HSA-190873 4.652501e-03 2.332 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 4.754480e-03 2.323 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 4.754480e-03 2.323 0 0
VLDLR internalisation and degradation R-HSA-8866427 4.754480e-03 2.323 0 0
Degradation of DVL R-HSA-4641258 4.761000e-03 2.322 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 4.761000e-03 2.322 0 0
Death Receptor Signaling R-HSA-73887 5.037995e-03 2.298 0 0
Signaling by MET R-HSA-6806834 5.080375e-03 2.294 0 0
Signaling by NTRKs R-HSA-166520 5.133207e-03 2.290 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 5.248620e-03 2.280 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 5.307574e-03 2.275 0 0
Meiotic synapsis R-HSA-1221632 5.771160e-03 2.239 0 0
Smooth Muscle Contraction R-HSA-445355 5.771160e-03 2.239 0 0
Striated Muscle Contraction R-HSA-390522 5.813151e-03 2.236 0 0
Vpu mediated degradation of CD4 R-HSA-180534 5.813151e-03 2.236 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 6.045885e-03 2.219 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 6.045885e-03 2.219 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 6.140012e-03 2.212 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 6.189281e-03 2.208 0 0
Nef and signal transduction R-HSA-164944 6.189281e-03 2.208 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 6.533915e-03 2.185 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 6.533915e-03 2.185 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 6.533915e-03 2.185 0 0
Frs2-mediated activation R-HSA-170968 6.533915e-03 2.185 0 0
Immune System R-HSA-168256 6.568522e-03 2.183 0 0
Basigin interactions R-HSA-210991 6.641657e-03 2.178 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 6.774335e-03 2.169 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 6.774335e-03 2.169 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 6.774335e-03 2.169 0 0
Signal attenuation R-HSA-74749 6.774335e-03 2.169 0 0
Josephin domain DUBs R-HSA-5689877 6.774335e-03 2.169 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 6.777341e-03 2.169 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 6.992066e-03 2.155 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 6.992066e-03 2.155 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 6.992066e-03 2.155 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 7.083707e-03 2.150 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 7.083707e-03 2.150 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 7.128401e-03 2.147 0 0
Signaling by NOTCH R-HSA-157118 7.178294e-03 2.144 0 0
DNA Replication R-HSA-69306 7.818474e-03 2.107 0 0
ER to Golgi Anterograde Transport R-HSA-199977 8.010243e-03 2.096 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 8.012374e-03 2.096 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 8.012374e-03 2.096 0 0
Signaling by TGFB family members R-HSA-9006936 8.253668e-03 2.083 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 8.351423e-03 2.078 0 0
Signalling to ERKs R-HSA-187687 8.351423e-03 2.078 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 8.351423e-03 2.078 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 8.365237e-03 2.078 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 8.365237e-03 2.078 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 8.375040e-03 2.077 0 0
Signaling by EGFR in Cancer R-HSA-1643713 8.606322e-03 2.065 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 8.606322e-03 2.065 0 0
Switching of origins to a post-replicative state R-HSA-69052 8.777415e-03 2.057 0 0
TNF signaling R-HSA-75893 8.845936e-03 2.053 0 0
Ion homeostasis R-HSA-5578775 8.845936e-03 2.053 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 8.845936e-03 2.053 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 8.866407e-03 2.052 0 0
DAG and IP3 signaling R-HSA-1489509 8.866407e-03 2.052 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 8.866407e-03 2.052 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 8.909078e-03 2.050 0 0
PKMTs methylate histone lysines R-HSA-3214841 9.418119e-03 2.026 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 9.418119e-03 2.026 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.418119e-03 2.026 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 9.418119e-03 2.026 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 9.468097e-03 2.024 0 0
Regulation of PTEN localization R-HSA-8948747 9.468097e-03 2.024 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 9.630816e-03 2.016 0 0
NF-kB is activated and signals survival R-HSA-209560 1.298298e-02 1.887 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.151286e-02 1.939 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 1.249909e-02 1.903 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.028991e-02 1.988 0 0
RET signaling R-HSA-8853659 9.908853e-03 2.004 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 1.029267e-02 1.987 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 1.189260e-02 1.925 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 1.099200e-02 1.959 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.153580e-02 1.938 0 0
Regulation of necroptotic cell death R-HSA-5675482 1.226134e-02 1.911 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 9.882161e-03 2.005 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.049056e-02 1.979 0 0
Protein methylation R-HSA-8876725 1.151286e-02 1.939 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 1.223450e-02 1.912 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 1.267269e-02 1.897 0 0
Ovarian tumor domain proteases R-HSA-5689896 1.168238e-02 1.932 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.298298e-02 1.887 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.139448e-02 1.943 0 0
p75NTR signals via NF-kB R-HSA-193639 1.151286e-02 1.939 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.226134e-02 1.911 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.012034e-02 1.995 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.908853e-03 2.004 0 0
Degradation of AXIN R-HSA-4641257 1.168238e-02 1.932 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 1.226134e-02 1.911 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.226134e-02 1.911 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.176779e-02 1.929 0 0
Cellular response to chemical stress R-HSA-9711123 1.186990e-02 1.926 0 0
Signaling by NOTCH4 R-HSA-9013694 9.882161e-03 2.005 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.051789e-02 1.978 0 0
snRNP Assembly R-HSA-191859 1.310245e-02 1.883 0 0
Metabolism of non-coding RNA R-HSA-194441 1.310245e-02 1.883 0 0
Intraflagellar transport R-HSA-5620924 1.367952e-02 1.864 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 1.377930e-02 1.861 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 1.434543e-02 1.843 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.450758e-02 1.838 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.475524e-02 1.831 0 0
Diseases of Cellular Senescence R-HSA-9630747 1.475524e-02 1.831 0 0
Diseases of cellular response to stress R-HSA-9675132 1.475524e-02 1.831 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.475524e-02 1.831 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.475524e-02 1.831 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.475524e-02 1.831 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.475524e-02 1.831 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.475524e-02 1.831 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.475524e-02 1.831 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.475524e-02 1.831 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.475524e-02 1.831 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.475524e-02 1.831 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.475524e-02 1.831 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.475524e-02 1.831 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 1.481194e-02 1.829 0 0
Negative regulation of FLT3 R-HSA-9706369 1.483310e-02 1.829 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.483310e-02 1.829 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.517964e-02 1.819 0 0
DNA methylation R-HSA-5334118 1.517964e-02 1.819 0 0
Platelet calcium homeostasis R-HSA-418360 1.517964e-02 1.819 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 1.517964e-02 1.819 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.529598e-02 1.815 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.545954e-02 1.811 0 0
Signal transduction by L1 R-HSA-445144 1.556657e-02 1.808 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 1.559156e-02 1.807 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.559156e-02 1.807 0 0
Neurodegenerative Diseases R-HSA-8863678 1.559156e-02 1.807 0 0
DNA Damage Bypass R-HSA-73893 1.566685e-02 1.805 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 1.625739e-02 1.789 0 0
Signaling by NOTCH3 R-HSA-9012852 1.629443e-02 1.788 0 0
PLC beta mediated events R-HSA-112043 1.673046e-02 1.776 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 1.696441e-02 1.770 0 0
G-protein mediated events R-HSA-112040 1.700618e-02 1.769 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 1.705056e-02 1.768 0 0
Mitophagy R-HSA-5205647 1.705056e-02 1.768 0 0
Netrin-1 signaling R-HSA-373752 1.705383e-02 1.768 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.714845e-02 1.766 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.724110e-02 1.763 0 0
p75NTR recruits signalling complexes R-HSA-209543 1.724110e-02 1.763 0 0
Activation of BH3-only proteins R-HSA-114452 1.803803e-02 1.744 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 1.848254e-02 1.733 0 0
Generation of second messenger molecules R-HSA-202433 1.848254e-02 1.733 0 0
Infectious disease R-HSA-5663205 1.867612e-02 1.729 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 1.878411e-02 1.726 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.878411e-02 1.726 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 1.891250e-02 1.723 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.901866e-02 1.721 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.914469e-02 1.718 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.924598e-02 1.716 0 0
ALK mutants bind TKIs R-HSA-9700645 1.924598e-02 1.716 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 1.954365e-02 1.709 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.957640e-02 1.708 0 0
Maturation of protein E R-HSA-9683683 1.957640e-02 1.708 0 0
Maturation of protein E R-HSA-9694493 1.957640e-02 1.708 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 2.029663e-02 1.693 0 0
Downstream signal transduction R-HSA-186763 2.127393e-02 1.672 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.130333e-02 1.672 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 2.130333e-02 1.672 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 2.327377e-02 1.633 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 2.327377e-02 1.633 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 2.327377e-02 1.633 0 0
Degradation of CRY and PER proteins R-HSA-9932298 2.443097e-02 1.612 0 0
MyD88-independent TLR4 cascade R-HSA-166166 2.493971e-02 1.603 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 2.493971e-02 1.603 0 0
Chromosome Maintenance R-HSA-73886 2.540103e-02 1.595 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 2.597127e-02 1.586 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 2.597127e-02 1.586 0 0
Pexophagy R-HSA-9664873 2.597127e-02 1.586 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 2.616048e-02 1.582 0 0
MET interacts with TNS proteins R-HSA-8875513 2.629217e-02 1.580 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 2.629217e-02 1.580 0 0
MET activates PTPN11 R-HSA-8865999 2.629217e-02 1.580 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.632129e-02 1.580 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.697840e-02 1.569 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.697840e-02 1.569 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.697840e-02 1.569 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.697840e-02 1.569 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.697840e-02 1.569 0 0
Developmental Cell Lineages R-HSA-9734767 2.754967e-02 1.560 0 0
Signaling by KIT in disease R-HSA-9669938 2.799137e-02 1.553 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 2.799137e-02 1.553 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 2.811418e-02 1.551 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 2.844109e-02 1.546 0 0
Regulation of KIT signaling R-HSA-1433559 2.844109e-02 1.546 0 0
NRIF signals cell death from the nucleus R-HSA-205043 2.844109e-02 1.546 0 0
Unfolded Protein Response (UPR) R-HSA-381119 2.848423e-02 1.545 0 0
Gluconeogenesis R-HSA-70263 2.865309e-02 1.543 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.878635e-02 1.541 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.878635e-02 1.541 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 2.893951e-02 1.539 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.897782e-02 1.538 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 2.897782e-02 1.538 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 3.061542e-02 1.514 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 3.111994e-02 1.507 0 0
Sensory processing of sound R-HSA-9659379 3.142374e-02 1.503 0 0
Signaling by Nuclear Receptors R-HSA-9006931 3.148411e-02 1.502 0 0
Signaling by SCF-KIT R-HSA-1433557 3.167484e-02 1.499 0 0
Signaling by FGFR4 R-HSA-5654743 3.167484e-02 1.499 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 3.253623e-02 1.488 0 0
Homology Directed Repair R-HSA-5693538 3.297843e-02 1.482 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 3.415695e-02 1.467 0 0
Translesion Synthesis by POLH R-HSA-110320 3.492832e-02 1.457 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 3.492832e-02 1.457 0 0
Rap1 signalling R-HSA-392517 3.492832e-02 1.457 0 0
STING mediated induction of host immune responses R-HSA-1834941 3.492832e-02 1.457 0 0
Regulation of gap junction activity R-HSA-191650 4.147673e-02 1.382 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 4.147673e-02 1.382 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 4.147673e-02 1.382 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.147673e-02 1.382 0 0
Signaling by MAP2K mutants R-HSA-9652169 4.147673e-02 1.382 0 0
SOS-mediated signalling R-HSA-112412 3.939361e-02 1.405 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 3.939361e-02 1.405 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 5.240310e-02 1.281 0 0
MET receptor recycling R-HSA-8875656 5.240310e-02 1.281 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 5.240310e-02 1.281 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 5.240310e-02 1.281 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 3.550477e-02 1.450 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 3.550477e-02 1.450 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 3.550477e-02 1.450 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 4.360636e-02 1.360 0 0
Deadenylation of mRNA R-HSA-429947 3.932511e-02 1.405 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 4.599749e-02 1.337 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 4.599749e-02 1.337 0 0
Late endosomal microautophagy R-HSA-9615710 3.644165e-02 1.438 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 4.219303e-02 1.375 0 0
G1/S-Specific Transcription R-HSA-69205 4.992861e-02 1.302 0 0
Transcription of the HIV genome R-HSA-167172 3.570449e-02 1.447 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 4.324401e-02 1.364 0 0
Processing of DNA double-strand break ends R-HSA-5693607 3.773782e-02 1.423 0 0
Opioid Signalling R-HSA-111885 3.951331e-02 1.403 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 4.147673e-02 1.382 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 4.147673e-02 1.382 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 4.360636e-02 1.360 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 3.847679e-02 1.415 0 0
RNA Polymerase I Transcription R-HSA-73864 5.039273e-02 1.298 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 4.852536e-02 1.314 0 0
Trafficking of AMPA receptors R-HSA-399719 4.852536e-02 1.314 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 4.515513e-02 1.345 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 4.489595e-02 1.348 0 0
ER-Phagosome pathway R-HSA-1236974 4.732277e-02 1.325 0 0
Regulated Necrosis R-HSA-5218859 3.570449e-02 1.447 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 4.741152e-02 1.324 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.644165e-02 1.438 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 3.932511e-02 1.405 0 0
DNA Repair R-HSA-73894 4.984580e-02 1.302 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 3.939361e-02 1.405 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 4.704497e-02 1.327 0 0
Transmission across Chemical Synapses R-HSA-112315 4.669389e-02 1.331 0 0
Signaling by FGFR3 R-HSA-5654741 4.034232e-02 1.394 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 4.395004e-02 1.357 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 5.240310e-02 1.281 0 0
Cellular response to hypoxia R-HSA-1234174 4.850189e-02 1.314 0 0
Platelet degranulation R-HSA-114608 4.219921e-02 1.375 0 0
tRNA processing in the nucleus R-HSA-6784531 3.610632e-02 1.442 0 0
Hemostasis R-HSA-109582 3.702636e-02 1.431 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 5.240310e-02 1.281 0 0
Interleukin-7 signaling R-HSA-1266695 4.599749e-02 1.337 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 3.610632e-02 1.442 0 0
Hedgehog 'on' state R-HSA-5632684 4.741152e-02 1.324 0 0
Hedgehog ligand biogenesis R-HSA-5358346 4.052377e-02 1.392 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 4.034232e-02 1.394 0 0
Modulation by Mtb of host immune system R-HSA-9637628 5.240310e-02 1.281 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 5.277695e-02 1.278 0 0
Synthesis of DNA R-HSA-69239 5.315137e-02 1.274 0 0
Regulation of endogenous retroelements R-HSA-9842860 5.531925e-02 1.257 0 0
Manipulation of host energy metabolism R-HSA-9636667 5.593156e-02 1.252 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 5.593156e-02 1.252 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 5.593156e-02 1.252 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 5.593156e-02 1.252 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 5.593156e-02 1.252 0 0
Breakdown of the nuclear lamina R-HSA-352238 5.593156e-02 1.252 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 5.625304e-02 1.250 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 5.642668e-02 1.249 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 5.642668e-02 1.249 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 5.661650e-02 1.247 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 5.754794e-02 1.240 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 5.832470e-02 1.234 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 5.832470e-02 1.234 0 0
MAP kinase activation R-HSA-450294 5.982372e-02 1.223 0 0
Viral Messenger RNA Synthesis R-HSA-168325 5.982372e-02 1.223 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 6.016845e-02 1.221 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 6.016845e-02 1.221 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 6.016845e-02 1.221 0 0
IRS activation R-HSA-74713 6.016845e-02 1.221 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 6.016845e-02 1.221 0 0
Packaging Of Telomere Ends R-HSA-171306 6.145898e-02 1.211 0 0
Integrin signaling R-HSA-354192 6.299695e-02 1.201 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 6.299695e-02 1.201 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 6.299695e-02 1.201 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 6.303476e-02 1.200 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 6.303476e-02 1.200 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 6.303476e-02 1.200 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 6.317344e-02 1.199 0 0
Response of Mtb to phagocytosis R-HSA-9637690 6.317344e-02 1.199 0 0
MET promotes cell motility R-HSA-8875878 6.345582e-02 1.198 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 6.670979e-02 1.176 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 6.670979e-02 1.176 0 0
Signaling by FGFR1 R-HSA-5654736 6.733329e-02 1.172 0 0
Lipophagy R-HSA-9613354 6.746833e-02 1.171 0 0
Calcineurin activates NFAT R-HSA-2025928 6.746833e-02 1.171 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 6.746833e-02 1.171 0 0
GP1b-IX-V activation signalling R-HSA-430116 6.746833e-02 1.171 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 6.746833e-02 1.171 0 0
Cellular response to mitochondrial stress R-HSA-9840373 6.746833e-02 1.171 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 6.785026e-02 1.168 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 6.785026e-02 1.168 0 0
HIV elongation arrest and recovery R-HSA-167287 7.027519e-02 1.153 0 0
Pausing and recovery of HIV elongation R-HSA-167290 7.027519e-02 1.153 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 7.027519e-02 1.153 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 7.027519e-02 1.153 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 7.159672e-02 1.145 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 7.250888e-02 1.140 0 0
Nucleotide Excision Repair R-HSA-5696398 7.303225e-02 1.136 0 0
PKA activation R-HSA-163615 7.438517e-02 1.129 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 7.438517e-02 1.129 0 0
Apoptotic factor-mediated response R-HSA-111471 7.438517e-02 1.129 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 7.438517e-02 1.129 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 7.590495e-02 1.120 0 0
Somitogenesis R-HSA-9824272 7.772193e-02 1.109 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 7.825456e-02 1.106 0 0
Growth hormone receptor signaling R-HSA-982772 7.825456e-02 1.106 0 0
Glycogen metabolism R-HSA-8982491 7.914001e-02 1.102 0 0
Termination of translesion DNA synthesis R-HSA-5656169 7.982427e-02 1.098 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 7.982427e-02 1.098 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 7.982427e-02 1.098 0 0
Regulation of gene expression in beta cells R-HSA-210745 7.982427e-02 1.098 0 0
Dual Incision in GG-NER R-HSA-5696400 7.994841e-02 1.097 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 7.994841e-02 1.097 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 7.994841e-02 1.097 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 7.998760e-02 1.097 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 8.045754e-02 1.094 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 8.045754e-02 1.094 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 8.210391e-02 1.086 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 8.210391e-02 1.086 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 8.210391e-02 1.086 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 8.210391e-02 1.086 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 8.210391e-02 1.086 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 8.210391e-02 1.086 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 8.331923e-02 1.079 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 8.331923e-02 1.079 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 8.331923e-02 1.079 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.331923e-02 1.079 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 8.452205e-02 1.073 0 0
Regulation of CDH11 function R-HSA-9762292 8.452205e-02 1.073 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 8.572354e-02 1.067 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 8.682103e-02 1.061 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 8.780432e-02 1.056 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 8.780432e-02 1.056 0 0
Activation of the pre-replicative complex R-HSA-68962 9.010642e-02 1.045 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 9.010642e-02 1.045 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 9.010642e-02 1.045 0 0
Interleukin-37 signaling R-HSA-9008059 9.010642e-02 1.045 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 9.117117e-02 1.040 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 9.117117e-02 1.040 0 0
Regulation of cortical dendrite branching R-HSA-8985801 9.170508e-02 1.038 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 9.170508e-02 1.038 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 9.386097e-02 1.028 0 0
Erythropoietin activates RAS R-HSA-9027284 9.559287e-02 1.020 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 9.559287e-02 1.020 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 9.559287e-02 1.020 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 9.559287e-02 1.020 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 9.559287e-02 1.020 0 0
Translesion synthesis by REV1 R-HSA-110312 9.559287e-02 1.020 0 0
IRE1alpha activates chaperones R-HSA-381070 9.570492e-02 1.019 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 9.799756e-02 1.009 0 0
Signaling by FGFR2 R-HSA-5654738 9.799756e-02 1.009 0 0
XBP1(S) activates chaperone genes R-HSA-381038 1.003087e-01 0.999 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.003232e-01 0.999 0 0
Protein hydroxylation R-HSA-9629569 1.003232e-01 0.999 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.011165e-01 0.995 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 1.011165e-01 0.995 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 1.016811e-01 0.993 0 0
PECAM1 interactions R-HSA-210990 1.034588e-01 0.985 0 0
Suppression of apoptosis R-HSA-9635465 1.034588e-01 0.985 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 1.034588e-01 0.985 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.034588e-01 0.985 0 0
Amyloid fiber formation R-HSA-977225 1.051447e-01 0.978 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 1.069402e-01 0.971 0 0
Signaling by LTK in cancer R-HSA-9842640 1.069402e-01 0.971 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 1.069402e-01 0.971 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 1.069402e-01 0.971 0 0
Drug resistance of FLT3 mutants R-HSA-9702506 1.186088e-01 0.926 0 0
Drug resistance of KIT mutants R-HSA-9669937 1.186088e-01 0.926 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.186088e-01 0.926 0 0
KIT mutants bind TKIs R-HSA-9669921 1.186088e-01 0.926 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.186088e-01 0.926 0 0
FLT3 mutants bind TKIs R-HSA-9702509 1.186088e-01 0.926 0 0
KW2449-resistant FLT3 mutants R-HSA-9702569 1.186088e-01 0.926 0 0
pexidartinib-resistant FLT3 mutants R-HSA-9702605 1.186088e-01 0.926 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 1.186088e-01 0.926 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.186088e-01 0.926 0 0
quizartinib-resistant FLT3 mutants R-HSA-9702620 1.186088e-01 0.926 0 0
tandutinib-resistant FLT3 mutants R-HSA-9702636 1.186088e-01 0.926 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 1.186088e-01 0.926 0 0
sorafenib-resistant FLT3 mutants R-HSA-9702624 1.186088e-01 0.926 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 1.186088e-01 0.926 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.186088e-01 0.926 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 1.186088e-01 0.926 0 0
linifanib-resistant FLT3 mutants R-HSA-9702998 1.186088e-01 0.926 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 1.186088e-01 0.926 0 0
sunitinib-resistant FLT3 mutants R-HSA-9702632 1.186088e-01 0.926 0 0
gilteritinib-resistant FLT3 mutants R-HSA-9702590 1.186088e-01 0.926 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 1.186088e-01 0.926 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.186088e-01 0.926 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.186088e-01 0.926 0 0
lestaurtinib-resistant FLT3 mutants R-HSA-9702596 1.186088e-01 0.926 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.186088e-01 0.926 0 0
semaxanib-resistant FLT3 mutants R-HSA-9702577 1.186088e-01 0.926 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 1.186088e-01 0.926 0 0
ponatinib-resistant FLT3 mutants R-HSA-9702614 1.186088e-01 0.926 0 0
midostaurin-resistant FLT3 mutants R-HSA-9702600 1.186088e-01 0.926 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 1.186088e-01 0.926 0 0
tamatinib-resistant FLT3 mutants R-HSA-9703009 1.186088e-01 0.926 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 1.186088e-01 0.926 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 1.186088e-01 0.926 0 0
crenolanib-resistant FLT3 mutants R-HSA-9702581 1.186088e-01 0.926 0 0
FasL/ CD95L signaling R-HSA-75157 1.322753e-01 0.879 0 0
MET activates STAT3 R-HSA-8875791 1.322753e-01 0.879 0 0
Axonal growth stimulation R-HSA-209563 1.322753e-01 0.879 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.760023e-01 0.754 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.760023e-01 0.754 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 1.760023e-01 0.754 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 1.760023e-01 0.754 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.342885e-01 0.872 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 1.342885e-01 0.872 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 1.342885e-01 0.872 0 0
IFNG signaling activates MAPKs R-HSA-9732724 1.342885e-01 0.872 0 0
TRIF-mediated programmed cell death R-HSA-2562578 1.342885e-01 0.872 0 0
Disinhibition of SNARE formation R-HSA-114516 1.342885e-01 0.872 0 0
Type I hemidesmosome assembly R-HSA-446107 1.637393e-01 0.786 0 0
Regulation by c-FLIP R-HSA-3371378 1.637393e-01 0.786 0 0
Dimerization of procaspase-8 R-HSA-69416 1.637393e-01 0.786 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 1.637393e-01 0.786 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 1.637393e-01 0.786 0 0
Activation of RAC1 R-HSA-428540 1.241426e-01 0.906 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.241426e-01 0.906 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.241426e-01 0.906 0 0
Translesion synthesis by POLI R-HSA-5656121 1.120620e-01 0.951 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 1.464139e-01 0.834 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.464139e-01 0.834 0 0
Scavenging by Class F Receptors R-HSA-3000484 1.464139e-01 0.834 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.464139e-01 0.834 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.464139e-01 0.834 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.464139e-01 0.834 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.464139e-01 0.834 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.948815e-01 0.710 0 0
ARMS-mediated activation R-HSA-170984 1.948815e-01 0.710 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 1.948815e-01 0.710 0 0
WNT mediated activation of DVL R-HSA-201688 1.948815e-01 0.710 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.948815e-01 0.710 0 0
Hypusine synthesis from eIF5A-lysine R-HSA-204626 1.948815e-01 0.710 0 0
CASP8 activity is inhibited R-HSA-5218900 1.948815e-01 0.710 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 1.297948e-01 0.887 0 0
Translesion synthesis by POLK R-HSA-5655862 1.297948e-01 0.887 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.700963e-01 0.769 0 0
Formation of axial mesoderm R-HSA-9796292 1.700963e-01 0.769 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.700963e-01 0.769 0 0
ERK/MAPK targets R-HSA-198753 1.148615e-01 0.940 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 1.148615e-01 0.940 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.487071e-01 0.828 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 1.950028e-01 0.710 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.950028e-01 0.710 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.950028e-01 0.710 0 0
Retrograde neurotrophin signalling R-HSA-177504 1.950028e-01 0.710 0 0
GAB1 signalosome R-HSA-180292 1.687033e-01 0.773 0 0
PKA activation in glucagon signalling R-HSA-164378 1.687033e-01 0.773 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 1.468749e-01 0.833 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 1.284928e-01 0.891 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.284928e-01 0.891 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.284928e-01 0.891 0 0
Signaling by Erythropoietin R-HSA-9006335 1.584673e-01 0.800 0 0
Co-inhibition by CTLA4 R-HSA-389513 2.115228e-01 0.675 0 0
DAP12 signaling R-HSA-2424491 1.745448e-01 0.758 0 0
HDMs demethylate histones R-HSA-3214842 2.013777e-01 0.696 0 0
Tight junction interactions R-HSA-420029 2.013777e-01 0.696 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 1.173521e-01 0.931 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 1.102216e-01 0.958 0 0
GPER1 signaling R-HSA-9634597 1.763235e-01 0.754 0 0
Signaling by ERBB4 R-HSA-1236394 1.620249e-01 0.790 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 1.456916e-01 0.837 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 1.140844e-01 0.943 0 0
Co-stimulation by CD28 R-HSA-389356 1.763235e-01 0.754 0 0
Integration of provirus R-HSA-162592 1.241426e-01 0.906 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 1.148615e-01 0.940 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 1.234477e-01 0.909 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 2.080067e-01 0.682 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 1.342885e-01 0.872 0 0
CRMPs in Sema3A signaling R-HSA-399956 1.950028e-01 0.710 0 0
Myogenesis R-HSA-525793 1.146753e-01 0.941 0 0
Interleukin-17 signaling R-HSA-448424 1.241393e-01 0.906 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.035261e-01 0.691 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 1.760023e-01 0.754 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 1.700963e-01 0.769 0 0
E2F mediated regulation of DNA replication R-HSA-113510 1.896789e-01 0.722 0 0
DARPP-32 events R-HSA-180024 1.584673e-01 0.800 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 2.013777e-01 0.696 0 0
Signaling by PDGF R-HSA-186797 1.810744e-01 0.742 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 1.904994e-01 0.720 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 1.464139e-01 0.834 0 0
G alpha (12/13) signalling events R-HSA-416482 1.352017e-01 0.869 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 1.297948e-01 0.887 0 0
Toll-like Receptor Cascades R-HSA-168898 2.140495e-01 0.669 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 1.948815e-01 0.710 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 1.950028e-01 0.710 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.722743e-01 0.764 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 1.554767e-01 0.808 0 0
Adaptive Immune System R-HSA-1280218 1.467842e-01 0.833 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 1.380494e-01 0.860 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 1.554767e-01 0.808 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 1.554767e-01 0.808 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.534829e-01 0.814 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 1.997960e-01 0.699 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 1.719362e-01 0.765 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 1.982822e-01 0.703 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.423913e-01 0.847 0 0
Neuronal System R-HSA-112316 1.896137e-01 0.722 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 1.102216e-01 0.958 0 0
MTF1 activates gene expression R-HSA-5660489 1.760023e-01 0.754 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.760023e-01 0.754 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 1.760023e-01 0.754 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 1.464139e-01 0.834 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 1.431025e-01 0.844 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 1.190650e-01 0.924 0 0
Formation of paraxial mesoderm R-HSA-9793380 1.694617e-01 0.771 0 0
Downstream TCR signaling R-HSA-202424 1.299282e-01 0.886 0 0
Interleukin-1 signaling R-HSA-9020702 1.244955e-01 0.905 0 0
RUNX2 regulates bone development R-HSA-8941326 1.815500e-01 0.741 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 1.342885e-01 0.872 0 0
Antigen processing-Cross presentation R-HSA-1236975 1.904994e-01 0.720 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 1.881831e-01 0.725 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 1.120620e-01 0.951 0 0
Potential therapeutics for SARS R-HSA-9679191 1.730435e-01 0.762 0 0
Ion transport by P-type ATPases R-HSA-936837 1.303832e-01 0.885 0 0
Interleukin-6 signaling R-HSA-1059683 1.700963e-01 0.769 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 1.464139e-01 0.834 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 1.464139e-01 0.834 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 1.128443e-01 0.948 0 0
Interleukin-1 family signaling R-HSA-446652 1.381220e-01 0.860 0 0
Signal regulatory protein family interactions R-HSA-391160 1.950028e-01 0.710 0 0
ABC-family proteins mediated transport R-HSA-382556 1.730398e-01 0.762 0 0
Reproduction R-HSA-1474165 1.201705e-01 0.920 0 0
NRAGE signals death through JNK R-HSA-193648 1.917449e-01 0.717 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.259062e-01 0.900 0 0
ABC transporter disorders R-HSA-5619084 2.051688e-01 0.688 0 0
IRAK1 recruits IKK complex R-HSA-937039 1.464139e-01 0.834 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 1.464139e-01 0.834 0 0
Plasma lipoprotein clearance R-HSA-8964043 1.332325e-01 0.875 0 0
Cleavage of the damaged purine R-HSA-110331 1.971057e-01 0.705 0 0
Depurination R-HSA-73927 2.131832e-01 0.671 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 1.128443e-01 0.948 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 2.115228e-01 0.675 0 0
Inositol phosphate metabolism R-HSA-1483249 1.635876e-01 0.786 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 1.863493e-01 0.730 0 0
Depyrimidination R-HSA-73928 1.863493e-01 0.730 0 0
Glycogen synthesis R-HSA-3322077 2.115228e-01 0.675 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 2.146883e-01 0.668 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 2.155656e-01 0.666 0 0
Proteasome assembly R-HSA-9907900 2.159256e-01 0.666 0 0
Dual incision in TC-NER R-HSA-6782135 2.180620e-01 0.661 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.209407e-01 0.656 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 2.209407e-01 0.656 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.209407e-01 0.656 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 2.210002e-01 0.656 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 2.210002e-01 0.656 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 2.210002e-01 0.656 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 2.215674e-01 0.654 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 2.215674e-01 0.654 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 2.215674e-01 0.654 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 2.215674e-01 0.654 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 2.215674e-01 0.654 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 2.215674e-01 0.654 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 2.215674e-01 0.654 0 0
Signaling by FGFR R-HSA-190236 2.231430e-01 0.651 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 2.231556e-01 0.651 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 2.231556e-01 0.651 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.231556e-01 0.651 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.231556e-01 0.651 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.231556e-01 0.651 0 0
Hereditary fructose intolerance R-HSA-5657560 2.231556e-01 0.651 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 2.231556e-01 0.651 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 2.231556e-01 0.651 0 0
RPIA deficiency: failed conversion of RU5P to R5P R-HSA-6791461 2.231556e-01 0.651 0 0
SARS-CoV-1 targets PDZ proteins in cell-cell junction R-HSA-9692912 2.231556e-01 0.651 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 2.231556e-01 0.651 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.231556e-01 0.651 0 0
RPIA deficiency: failed conversion of R5P to RU5P R-HSA-5659996 2.231556e-01 0.651 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.231556e-01 0.651 0 0
TICAM1 deficiency - HSE R-HSA-5602566 2.231556e-01 0.651 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.231556e-01 0.651 0 0
Inhibition of PKR R-HSA-169131 2.231556e-01 0.651 0 0
Rab regulation of trafficking R-HSA-9007101 2.264614e-01 0.645 0 0
G-protein beta:gamma signalling R-HSA-397795 2.265649e-01 0.645 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.265649e-01 0.645 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.265649e-01 0.645 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 2.265649e-01 0.645 0 0
Activation of ATR in response to replication stress R-HSA-176187 2.265649e-01 0.645 0 0
PI3K/AKT activation R-HSA-198203 2.273158e-01 0.643 0 0
2-LTR circle formation R-HSA-164843 2.273158e-01 0.643 0 0
Regulation of the apoptosome activity R-HSA-9627069 2.273158e-01 0.643 0 0
Formation of apoptosome R-HSA-111458 2.273158e-01 0.643 0 0
Receptor Mediated Mitophagy R-HSA-8934903 2.273158e-01 0.643 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 2.273158e-01 0.643 0 0
Interleukin-27 signaling R-HSA-9020956 2.273158e-01 0.643 0 0
Signaling by Leptin R-HSA-2586552 2.273158e-01 0.643 0 0
RAS processing R-HSA-9648002 2.297414e-01 0.639 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 2.297414e-01 0.639 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 2.303129e-01 0.638 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 2.313638e-01 0.636 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 2.313638e-01 0.636 0 0
Regulation of beta-cell development R-HSA-186712 2.317470e-01 0.635 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 2.341197e-01 0.631 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 2.341197e-01 0.631 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 2.341197e-01 0.631 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 2.341197e-01 0.631 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 2.341197e-01 0.631 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 2.412230e-01 0.618 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 2.449876e-01 0.611 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 2.467368e-01 0.608 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 2.467368e-01 0.608 0 0
Signaling by TGFBR3 R-HSA-9839373 2.471903e-01 0.607 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 2.477166e-01 0.606 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 2.477166e-01 0.606 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 2.477166e-01 0.606 0 0
Regulation of BACH1 activity R-HSA-9708530 2.477166e-01 0.606 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.549573e-01 0.594 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 2.551232e-01 0.593 0 0
Protein ubiquitination R-HSA-8852135 2.554383e-01 0.593 0 0
Disease R-HSA-1643685 2.568431e-01 0.590 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 2.573520e-01 0.589 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 2.573520e-01 0.589 0 0
Assembly Of The HIV Virion R-HSA-175474 2.573520e-01 0.589 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 2.606647e-01 0.584 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 2.606647e-01 0.584 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 2.606647e-01 0.584 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 2.606647e-01 0.584 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 2.606647e-01 0.584 0 0
Bicarbonate transporters R-HSA-425381 2.606647e-01 0.584 0 0
Signaling by APC mutants R-HSA-4839744 2.606647e-01 0.584 0 0
Signaling by NOTCH2 R-HSA-1980145 2.638555e-01 0.579 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 2.679201e-01 0.572 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 2.679201e-01 0.572 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 2.679201e-01 0.572 0 0
Phosphorylation of Emi1 R-HSA-176417 2.679201e-01 0.572 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 2.679201e-01 0.572 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 2.679201e-01 0.572 0 0
Proton/oligopeptide cotransporters R-HSA-427975 2.679201e-01 0.572 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 2.679201e-01 0.572 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 2.679201e-01 0.572 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 2.751398e-01 0.560 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 2.751398e-01 0.560 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 2.751398e-01 0.560 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 2.751398e-01 0.560 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 2.751398e-01 0.560 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 2.751398e-01 0.560 0 0
G alpha (z) signalling events R-HSA-418597 2.773989e-01 0.557 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 2.811015e-01 0.551 0 0
Interferon alpha/beta signaling R-HSA-909733 2.812228e-01 0.551 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 2.818583e-01 0.550 0 0
HIV Transcription Initiation R-HSA-167161 2.818583e-01 0.550 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 2.818583e-01 0.550 0 0
Translation of Structural Proteins R-HSA-9683701 2.818583e-01 0.550 0 0
PERK regulates gene expression R-HSA-381042 2.831087e-01 0.548 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 2.831476e-01 0.548 0 0
HCMV Late Events R-HSA-9610379 2.944890e-01 0.531 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 2.945783e-01 0.531 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 2.945783e-01 0.531 0 0
ERKs are inactivated R-HSA-202670 2.945783e-01 0.531 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 2.945783e-01 0.531 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 2.945783e-01 0.531 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 2.945783e-01 0.531 0 0
Signaling by AXIN mutants R-HSA-4839735 2.945783e-01 0.531 0 0
Telomere Maintenance R-HSA-157579 2.946168e-01 0.531 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 3.030259e-01 0.519 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 3.030259e-01 0.519 0 0
Glycogen storage diseases R-HSA-3229121 3.030259e-01 0.519 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 3.040372e-01 0.517 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 3.052515e-01 0.515 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 3.052515e-01 0.515 0 0
Syndecan interactions R-HSA-3000170 3.052515e-01 0.515 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.142329e-01 0.503 0 0
STAT5 Activation R-HSA-9645135 3.142329e-01 0.503 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.142329e-01 0.503 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 3.142329e-01 0.503 0 0
CREB phosphorylation R-HSA-199920 3.142329e-01 0.503 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 3.142329e-01 0.503 0 0
Cardiac conduction R-HSA-5576891 3.145757e-01 0.502 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 3.153069e-01 0.501 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 3.153069e-01 0.501 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 3.153069e-01 0.501 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 3.153069e-01 0.501 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 3.153069e-01 0.501 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 3.153069e-01 0.501 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 3.153069e-01 0.501 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 3.153069e-01 0.501 0 0
Beta-ketothiolase deficiency R-HSA-9915355 3.153069e-01 0.501 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 3.153069e-01 0.501 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 3.153069e-01 0.501 0 0
Mitochondrial short-chain enoyl-CoA hydratase deficiency 1 R-HSA-9916720 3.153069e-01 0.501 0 0
Defective GFPT1 causes CMSTA1 R-HSA-4085023 3.153069e-01 0.501 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.153069e-01 0.501 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 3.153069e-01 0.501 0 0
TRAF3 deficiency - HSE R-HSA-5602571 3.153069e-01 0.501 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 3.153069e-01 0.501 0 0
Transport of connexins along the secretory pathway R-HSA-190827 3.153069e-01 0.501 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 3.153069e-01 0.501 0 0
Oligomerization of connexins into connexons R-HSA-190704 3.153069e-01 0.501 0 0
Inhibition of membrane repair R-HSA-9635644 3.153069e-01 0.501 0 0
NTRK3 as a dependence receptor R-HSA-9603505 3.153069e-01 0.501 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 3.181759e-01 0.497 0 0
TBC/RABGAPs R-HSA-8854214 3.181759e-01 0.497 0 0
Ion channel transport R-HSA-983712 3.207548e-01 0.494 1 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 3.257296e-01 0.487 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 3.257296e-01 0.487 0 0
Budding and maturation of HIV virion R-HSA-162588 3.265014e-01 0.486 0 0
MET activates RAS signaling R-HSA-8851805 3.287385e-01 0.483 0 0
GRB2 events in EGFR signaling R-HSA-179812 3.287385e-01 0.483 0 0
Regulation of IFNG signaling R-HSA-877312 3.287385e-01 0.483 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 3.287385e-01 0.483 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 3.287385e-01 0.483 0 0
Interleukin-35 Signalling R-HSA-8984722 3.287385e-01 0.483 0 0
Signaling by LTK R-HSA-9842663 3.287385e-01 0.483 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 3.296878e-01 0.482 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 3.296878e-01 0.482 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 3.296878e-01 0.482 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 3.311987e-01 0.480 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 3.311987e-01 0.480 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 3.379095e-01 0.471 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 3.415274e-01 0.467 0 0
Neurexins and neuroligins R-HSA-6794361 3.482453e-01 0.458 0 0
G0 and Early G1 R-HSA-1538133 3.485133e-01 0.458 0 0
Stimuli-sensing channels R-HSA-2672351 3.500384e-01 0.456 1 1
HDR through Homologous Recombination (HRR) R-HSA-5685942 3.506599e-01 0.455 0 0
TGFBR3 expression R-HSA-9839394 3.543003e-01 0.451 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 3.543003e-01 0.451 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 3.553108e-01 0.449 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 3.553108e-01 0.449 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 3.594928e-01 0.444 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 3.594928e-01 0.444 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 3.594928e-01 0.444 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 3.594928e-01 0.444 0 0
The NLRP3 inflammasome R-HSA-844456 3.594928e-01 0.444 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 3.594928e-01 0.444 0 0
Recycling of eIF2:GDP R-HSA-72731 3.598635e-01 0.444 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.598635e-01 0.444 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 3.598635e-01 0.444 0 0
CHL1 interactions R-HSA-447041 3.598635e-01 0.444 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 3.598635e-01 0.444 0 0
SLC-mediated transport of oligopeptides R-HSA-9959399 3.598635e-01 0.444 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 3.602464e-01 0.443 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 3.602464e-01 0.443 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 3.627636e-01 0.440 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 3.627636e-01 0.440 0 0
CD28 dependent Vav1 pathway R-HSA-389359 3.628609e-01 0.440 0 0
Maturation of nucleoprotein R-HSA-9683610 3.628609e-01 0.440 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 3.628609e-01 0.440 0 0
Cardiogenesis R-HSA-9733709 3.706447e-01 0.431 0 0
Base Excision Repair R-HSA-73884 3.718572e-01 0.430 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 3.740674e-01 0.427 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 3.789835e-01 0.421 0 0
Suppression of phagosomal maturation R-HSA-9637687 3.789835e-01 0.421 0 0
Integration of energy metabolism R-HSA-163685 3.801152e-01 0.420 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 3.830398e-01 0.417 0 0
HIV Transcription Elongation R-HSA-167169 3.830398e-01 0.417 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 3.830398e-01 0.417 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 3.833405e-01 0.416 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 3.877542e-01 0.411 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 3.877542e-01 0.411 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 3.877542e-01 0.411 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 3.877542e-01 0.411 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 3.877542e-01 0.411 0 0
Signaling by NODAL R-HSA-1181150 3.877542e-01 0.411 0 0
NCAM signaling for neurite out-growth R-HSA-375165 3.911430e-01 0.408 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 3.928212e-01 0.406 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 3.928890e-01 0.406 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 3.928890e-01 0.406 0 0
Protein-protein interactions at synapses R-HSA-6794362 3.943815e-01 0.404 0 0
Activation of HOX genes during differentiation R-HSA-5619507 3.954628e-01 0.403 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 3.954628e-01 0.403 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.965317e-01 0.402 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 3.965317e-01 0.402 0 0
Defective AHCY causes HMAHCHD R-HSA-5578997 3.965317e-01 0.402 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 3.965317e-01 0.402 0 0
Signaling by RAS GAP mutants R-HSA-9753510 3.965317e-01 0.402 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 3.965317e-01 0.402 0 0
mRNA Editing: A to I Conversion R-HSA-75064 3.965317e-01 0.402 0 0
C6 deamination of adenosine R-HSA-75102 3.965317e-01 0.402 0 0
Defective ABCC8 can cause hypo- and hyper-glycemias R-HSA-5683177 3.965317e-01 0.402 0 0
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization R-HSA-180897 3.965317e-01 0.402 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 3.965317e-01 0.402 0 0
Signalling to ERK5 R-HSA-198765 3.965317e-01 0.402 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 3.965317e-01 0.402 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 3.965317e-01 0.402 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 3.965317e-01 0.402 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 3.966953e-01 0.402 0 0
Signaling by FGFR4 in disease R-HSA-5655291 3.966953e-01 0.402 0 0
Physiological factors R-HSA-5578768 3.966953e-01 0.402 0 0
HDL assembly R-HSA-8963896 3.966953e-01 0.402 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 4.036378e-01 0.394 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 4.036378e-01 0.394 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 4.036378e-01 0.394 0 0
phospho-PLA2 pathway R-HSA-111995 4.043223e-01 0.393 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 4.043223e-01 0.393 0 0
Adrenoceptors R-HSA-390696 4.043223e-01 0.393 0 0
TGFBR3 PTM regulation R-HSA-9839383 4.043223e-01 0.393 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 4.043223e-01 0.393 0 0
Interleukin-9 signaling R-HSA-8985947 4.043223e-01 0.393 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 4.043223e-01 0.393 0 0
RSK activation R-HSA-444257 4.043223e-01 0.393 0 0
Circadian clock R-HSA-9909396 4.105777e-01 0.387 0 0
NGF-stimulated transcription R-HSA-9031628 4.117312e-01 0.385 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 4.149716e-01 0.382 0 0
Calnexin/calreticulin cycle R-HSA-901042 4.149716e-01 0.382 0 0
NOD1/2 Signaling Pathway R-HSA-168638 4.149716e-01 0.382 0 0
Early Phase of HIV Life Cycle R-HSA-162594 4.158420e-01 0.381 0 0
Signalling to RAS R-HSA-167044 4.158420e-01 0.381 0 0
FOXO-mediated transcription R-HSA-9614085 4.175973e-01 0.379 0 0
Insulin receptor signalling cascade R-HSA-74751 4.244721e-01 0.372 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 4.244721e-01 0.372 0 0
Leishmania phagocytosis R-HSA-9664417 4.249505e-01 0.372 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 4.249505e-01 0.372 0 0
Parasite infection R-HSA-9664407 4.249505e-01 0.372 0 0
Pyroptosis R-HSA-5620971 4.281701e-01 0.368 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 4.300250e-01 0.367 0 0
p38MAPK events R-HSA-171007 4.300250e-01 0.367 0 0
SHC1 events in EGFR signaling R-HSA-180336 4.300250e-01 0.367 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 4.300250e-01 0.367 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 4.305512e-01 0.366 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 4.438351e-01 0.353 0 0
Ca2+ pathway R-HSA-4086398 4.453112e-01 0.351 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 4.472454e-01 0.349 0 0
MAPK1 (ERK2) activation R-HSA-112411 4.472454e-01 0.349 0 0
p75NTR regulates axonogenesis R-HSA-193697 4.472454e-01 0.349 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 4.472454e-01 0.349 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 4.472454e-01 0.349 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 4.472454e-01 0.349 0 0
Unwinding of DNA R-HSA-176974 4.472454e-01 0.349 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 4.472454e-01 0.349 0 0
Interleukin-21 signaling R-HSA-9020958 4.472454e-01 0.349 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 4.472454e-01 0.349 0 0
Regulated proteolysis of p75NTR R-HSA-193692 4.472454e-01 0.349 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 4.472454e-01 0.349 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 4.472454e-01 0.349 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 4.472454e-01 0.349 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 4.472454e-01 0.349 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 4.589282e-01 0.338 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 4.626656e-01 0.335 0 0
Phosphorylation of the APC/C R-HSA-176412 4.626656e-01 0.335 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 4.626656e-01 0.335 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 4.626656e-01 0.335 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 4.681250e-01 0.330 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 4.681250e-01 0.330 0 0
Signalling to STAT3 R-HSA-198745 4.681250e-01 0.330 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 4.681250e-01 0.330 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.681250e-01 0.330 0 0
FGFR2 alternative splicing R-HSA-6803529 4.709991e-01 0.327 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 4.709991e-01 0.327 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 4.709991e-01 0.327 0 0
LDL clearance R-HSA-8964038 4.709991e-01 0.327 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 4.765294e-01 0.322 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 4.790343e-01 0.320 0 0
DAP12 interactions R-HSA-2172127 4.838274e-01 0.315 0 0
MAPK3 (ERK1) activation R-HSA-110056 4.883716e-01 0.311 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.883716e-01 0.311 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 4.883716e-01 0.311 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 4.883716e-01 0.311 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 4.883716e-01 0.311 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 4.944632e-01 0.306 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 4.944632e-01 0.306 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 4.944632e-01 0.306 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 4.944632e-01 0.306 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 4.978534e-01 0.303 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 5.020244e-01 0.299 0 0
Aquaporin-mediated transport R-HSA-445717 5.059451e-01 0.296 0 0
Mitochondrial protein import R-HSA-1268020 5.229944e-01 0.282 0 0
Pentose phosphate pathway R-HSA-71336 5.231160e-01 0.281 0 0
Signaling by WNT in cancer R-HSA-4791275 5.234560e-01 0.281 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 5.241036e-01 0.281 0 0
Interleukin-6 family signaling R-HSA-6783589 5.241036e-01 0.281 0 0
Platelet homeostasis R-HSA-418346 5.241494e-01 0.281 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 5.252920e-01 0.280 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 5.252920e-01 0.280 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 5.252920e-01 0.280 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 5.252920e-01 0.280 0 0
Uptake and function of anthrax toxins R-HSA-5210891 5.252920e-01 0.280 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 5.275232e-01 0.278 0 0
vRNP Assembly R-HSA-192905 5.275232e-01 0.278 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 5.275232e-01 0.278 0 0
Interleukin-2 signaling R-HSA-9020558 5.275232e-01 0.278 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 5.275232e-01 0.278 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 5.277340e-01 0.278 0 0
HCN channels R-HSA-1296061 5.312285e-01 0.275 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 5.312285e-01 0.275 0 0
ATP sensitive Potassium channels R-HSA-1296025 5.312285e-01 0.275 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 5.312285e-01 0.275 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 5.312285e-01 0.275 0 0
Defective FMO3 causes TMAU R-HSA-5579019 5.312285e-01 0.275 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 5.312285e-01 0.275 0 0
GABA synthesis R-HSA-888568 5.312285e-01 0.275 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 5.312285e-01 0.275 0 0
NADE modulates death signalling R-HSA-205025 5.312285e-01 0.275 0 0
TNFR1-mediated ceramide production R-HSA-5626978 5.312285e-01 0.275 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 5.380217e-01 0.269 0 0
Interleukin-2 family signaling R-HSA-451927 5.438410e-01 0.265 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 5.462248e-01 0.263 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 5.496747e-01 0.260 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 5.550520e-01 0.256 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 5.550520e-01 0.256 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 5.550520e-01 0.256 0 0
Synaptic adhesion-like molecules R-HSA-8849932 5.550520e-01 0.256 0 0
Platelet sensitization by LDL R-HSA-432142 5.550520e-01 0.256 0 0
Presynaptic function of Kainate receptors R-HSA-500657 5.550520e-01 0.256 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 5.550520e-01 0.256 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 5.641587e-01 0.249 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 5.645900e-01 0.248 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 5.645900e-01 0.248 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 5.645900e-01 0.248 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 5.645900e-01 0.248 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 5.645900e-01 0.248 0 0
Sodium/Calcium exchangers R-HSA-425561 5.645900e-01 0.248 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 5.684610e-01 0.245 0 0
Effects of PIP2 hydrolysis R-HSA-114508 5.684610e-01 0.245 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 5.692809e-01 0.245 0 0
MET activates PTK2 signaling R-HSA-8874081 5.745038e-01 0.241 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 5.794072e-01 0.237 0 0
Protein localization R-HSA-9609507 5.799463e-01 0.237 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 5.836666e-01 0.234 0 0
Other interleukin signaling R-HSA-449836 5.836666e-01 0.234 0 0
Maturation of nucleoprotein R-HSA-9694631 5.836666e-01 0.234 0 0
Signaling by FGFR in disease R-HSA-1226099 5.857374e-01 0.232 0 0
G2 Phase R-HSA-68911 5.868483e-01 0.231 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.868483e-01 0.231 0 0
PTK6 Activates STAT3 R-HSA-8849474 5.868483e-01 0.231 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.868483e-01 0.231 0 0
Activation of AKT2 R-HSA-165158 5.868483e-01 0.231 0 0
PTK6 Down-Regulation R-HSA-8849472 5.868483e-01 0.231 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 5.868483e-01 0.231 0 0
Reelin signalling pathway R-HSA-8866376 5.868483e-01 0.231 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.868483e-01 0.231 0 0
Hydroxycarboxylic acid-binding receptors R-HSA-3296197 5.868483e-01 0.231 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 5.868483e-01 0.231 0 0
Co-inhibition by BTLA R-HSA-9927353 5.868483e-01 0.231 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 5.868483e-01 0.231 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 5.868483e-01 0.231 0 0
Parasitic Infection Pathways R-HSA-9824443 5.874149e-01 0.231 0 0
Leishmania infection R-HSA-9658195 5.874149e-01 0.231 0 0
Innate Immune System R-HSA-168249 5.888238e-01 0.230 0 0
Signal amplification R-HSA-392518 5.901214e-01 0.229 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 5.985395e-01 0.223 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 5.995154e-01 0.222 0 0
Polymerase switching R-HSA-69091 5.995154e-01 0.222 0 0
Leading Strand Synthesis R-HSA-69109 5.995154e-01 0.222 0 0
Interleukin-15 signaling R-HSA-8983432 5.995154e-01 0.222 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 5.995154e-01 0.222 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 5.995154e-01 0.222 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 5.995154e-01 0.222 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 5.995154e-01 0.222 0 0
Disorders of Nervous System Development R-HSA-9697154 5.995154e-01 0.222 0 0
Pervasive developmental disorders R-HSA-9005895 5.995154e-01 0.222 0 0
Iron uptake and transport R-HSA-917937 6.008111e-01 0.221 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 6.110801e-01 0.214 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 6.110801e-01 0.214 0 0
Formation of definitive endoderm R-HSA-9823730 6.110801e-01 0.214 0 0
Creatine metabolism R-HSA-71288 6.110801e-01 0.214 0 0
Signaling by NOTCH1 R-HSA-1980143 6.156184e-01 0.211 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 6.217408e-01 0.206 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 6.217408e-01 0.206 0 0
Inflammasomes R-HSA-622312 6.217408e-01 0.206 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 6.257457e-01 0.204 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 6.257457e-01 0.204 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 6.257457e-01 0.204 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 6.257457e-01 0.204 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 6.257457e-01 0.204 0 0
Metabolism of polyamines R-HSA-351202 6.257457e-01 0.204 0 0
Translation of Structural Proteins R-HSA-9694635 6.301448e-01 0.201 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 6.315744e-01 0.200 0 0
RNA Polymerase III Transcription R-HSA-74158 6.315744e-01 0.200 0 0
GPVI-mediated activation cascade R-HSA-114604 6.315744e-01 0.200 0 0
Triglyceride catabolism R-HSA-163560 6.315744e-01 0.200 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 6.322857e-01 0.199 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 6.322857e-01 0.199 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 6.322857e-01 0.199 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 6.324157e-01 0.199 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 6.349021e-01 0.197 0 0
Plus-strand DNA synthesis R-HSA-164525 6.358717e-01 0.197 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 6.358717e-01 0.197 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.358717e-01 0.197 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 6.358717e-01 0.197 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.358717e-01 0.197 0 0
Signaling by MAPK mutants R-HSA-9652817 6.358717e-01 0.197 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 6.358717e-01 0.197 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 6.358717e-01 0.197 0 0
Pentose phosphate pathway disease R-HSA-6791465 6.358717e-01 0.197 0 0
PKB-mediated events R-HSA-109703 6.358717e-01 0.197 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 6.358717e-01 0.197 0 0
Cam-PDE 1 activation R-HSA-111957 6.358717e-01 0.197 0 0
PDE3B signalling R-HSA-165160 6.358717e-01 0.197 0 0
Threonine catabolism R-HSA-8849175 6.358717e-01 0.197 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 6.358717e-01 0.197 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 6.358717e-01 0.197 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.358717e-01 0.197 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 6.358717e-01 0.197 0 0
VEGF ligand-receptor interactions R-HSA-194313 6.358717e-01 0.197 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 6.358717e-01 0.197 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 6.358717e-01 0.197 0 0
TRAIL signaling R-HSA-75158 6.358717e-01 0.197 0 0
G-protein activation R-HSA-202040 6.372552e-01 0.196 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 6.372552e-01 0.196 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 6.372552e-01 0.196 0 0
Disorders of transmembrane transporters R-HSA-5619115 6.403626e-01 0.194 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 6.513125e-01 0.186 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 6.585227e-01 0.181 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 6.598673e-01 0.181 0 0
Serine metabolism R-HSA-977347 6.621709e-01 0.179 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 6.629207e-01 0.179 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 6.629207e-01 0.179 0 0
Zinc transporters R-HSA-435354 6.629207e-01 0.179 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 6.629207e-01 0.179 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 6.703647e-01 0.174 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 6.757873e-01 0.170 0 0
Regulation of pyruvate metabolism R-HSA-9861718 6.757873e-01 0.170 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.790807e-01 0.168 0 0
Uncoating of the HIV Virion R-HSA-162585 6.790807e-01 0.168 0 0
Autointegration results in viral DNA circles R-HSA-177539 6.790807e-01 0.168 0 0
G2/M DNA replication checkpoint R-HSA-69478 6.790807e-01 0.168 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 6.790807e-01 0.168 0 0
MET Receptor Activation R-HSA-6806942 6.790807e-01 0.168 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 6.790807e-01 0.168 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 6.790807e-01 0.168 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 6.790807e-01 0.168 0 0
Lipid particle organization R-HSA-8964572 6.790807e-01 0.168 0 0
HDL clearance R-HSA-8964011 6.790807e-01 0.168 0 0
Leukotriene receptors R-HSA-391906 6.790807e-01 0.168 0 0
Neurofascin interactions R-HSA-447043 6.790807e-01 0.168 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 6.858200e-01 0.164 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 6.880920e-01 0.162 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 6.880920e-01 0.162 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 6.880920e-01 0.162 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 6.914656e-01 0.160 0 0
G beta:gamma signalling through BTK R-HSA-8964315 6.914656e-01 0.160 0 0
Signaling by Activin R-HSA-1502540 6.914656e-01 0.160 0 0
Neddylation R-HSA-8951664 6.960696e-01 0.157 0 0
DNA strand elongation R-HSA-69190 7.057117e-01 0.151 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 7.082074e-01 0.150 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 7.082074e-01 0.150 0 0
Formation of the ureteric bud R-HSA-9830674 7.082074e-01 0.150 0 0
IRS-mediated signalling R-HSA-112399 7.116772e-01 0.148 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 7.171645e-01 0.144 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 7.171645e-01 0.144 0 0
DAG1 core M1 glycosylations R-HSA-8932506 7.171645e-01 0.144 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 7.171645e-01 0.144 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 7.171645e-01 0.144 0 0
Opsins R-HSA-419771 7.171645e-01 0.144 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 7.171645e-01 0.144 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 7.171645e-01 0.144 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 7.171645e-01 0.144 0 0
Netrin mediated repulsion signals R-HSA-418886 7.171645e-01 0.144 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 7.171645e-01 0.144 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 7.171645e-01 0.144 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 7.179850e-01 0.144 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 7.179850e-01 0.144 0 0
Activation of SMO R-HSA-5635838 7.179850e-01 0.144 0 0
Mineralocorticoid biosynthesis R-HSA-193993 7.179850e-01 0.144 0 0
Differentiation of T cells R-HSA-9945266 7.179850e-01 0.144 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 7.179850e-01 0.144 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 7.179850e-01 0.144 0 0
Virus Assembly and Release R-HSA-168268 7.179850e-01 0.144 0 0
Regulation of insulin secretion R-HSA-422356 7.201358e-01 0.143 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 7.244431e-01 0.140 0 0
Nuclear RNA decay R-HSA-9930044 7.244431e-01 0.140 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 7.244431e-01 0.140 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 7.293480e-01 0.137 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 7.293480e-01 0.137 0 0
Mitochondrial RNA degradation R-HSA-9836573 7.293480e-01 0.137 0 0
Plasma lipoprotein assembly R-HSA-8963898 7.293480e-01 0.137 0 0
Signaling by Insulin receptor R-HSA-74752 7.384556e-01 0.132 0 0
PI3K Cascade R-HSA-109704 7.390573e-01 0.131 0 0
Peroxisomal protein import R-HSA-9033241 7.399503e-01 0.131 0 0
Resolution of D-Loop Structures R-HSA-5693537 7.422721e-01 0.129 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 7.422721e-01 0.129 0 0
tRNA modification in the mitochondrion R-HSA-6787450 7.425576e-01 0.129 0 0
Passive transport by Aquaporins R-HSA-432047 7.425576e-01 0.129 0 0
Disorders of Developmental Biology R-HSA-9675151 7.425576e-01 0.129 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 7.425576e-01 0.129 0 0
Response to metal ions R-HSA-5660526 7.425576e-01 0.129 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.492653e-01 0.125 0 0
Formation of the nephric duct R-HSA-9830364 7.492653e-01 0.125 0 0
Hyaluronan degradation R-HSA-2160916 7.492653e-01 0.125 0 0
Reverse Transcription of HIV RNA R-HSA-162589 7.507308e-01 0.125 0 0
Minus-strand DNA synthesis R-HSA-164516 7.507308e-01 0.125 0 0
DAG1 core M2 glycosylations R-HSA-8932504 7.507308e-01 0.125 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.507308e-01 0.125 0 0
Interleukin-23 signaling R-HSA-9020933 7.507308e-01 0.125 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 7.507308e-01 0.125 0 0
Activation of RAS in B cells R-HSA-1169092 7.507308e-01 0.125 0 0
FGFR1b ligand binding and activation R-HSA-190370 7.507308e-01 0.125 0 0
Alpha-defensins R-HSA-1462054 7.507308e-01 0.125 0 0
Sodium/Proton exchangers R-HSA-425986 7.507308e-01 0.125 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.507308e-01 0.125 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 7.507308e-01 0.125 0 0
The phototransduction cascade R-HSA-2514856 7.534086e-01 0.123 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 7.550294e-01 0.122 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 7.578344e-01 0.120 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 7.592096e-01 0.120 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 7.592096e-01 0.120 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 7.652719e-01 0.116 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 7.652719e-01 0.116 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 7.652719e-01 0.116 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 7.662193e-01 0.116 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 7.672877e-01 0.115 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 7.679895e-01 0.115 0 0
TRP channels R-HSA-3295583 7.679895e-01 0.115 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 7.679895e-01 0.115 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 7.752706e-01 0.111 0 0
Metabolism of proteins R-HSA-392499 7.758506e-01 0.110 0 0
Gastrulation R-HSA-9758941 7.796971e-01 0.108 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 7.803153e-01 0.108 0 0
mRNA Editing R-HSA-75072 7.803153e-01 0.108 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.803153e-01 0.108 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 7.803153e-01 0.108 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.803153e-01 0.108 0 0
Interleukin-1 processing R-HSA-448706 7.803153e-01 0.108 0 0
Amino acids regulate mTORC1 R-HSA-9639288 7.803625e-01 0.108 0 0
Cristae formation R-HSA-8949613 7.855566e-01 0.105 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 7.855566e-01 0.105 0 0
Signaling by FGFR3 in disease R-HSA-5655332 7.855566e-01 0.105 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 7.855566e-01 0.105 0 0
Mismatch Repair R-HSA-5358508 7.862228e-01 0.104 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 7.862228e-01 0.104 0 0
Tie2 Signaling R-HSA-210993 7.862228e-01 0.104 0 0
Nephron development R-HSA-9831926 7.862228e-01 0.104 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 7.893253e-01 0.103 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 7.904992e-01 0.102 0 0
RSV-host interactions R-HSA-9833110 7.915475e-01 0.102 0 0
Fanconi Anemia Pathway R-HSA-6783310 7.973937e-01 0.098 0 0
IGF1R signaling cascade R-HSA-2428924 8.019049e-01 0.096 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 8.020067e-01 0.096 0 0
Formation of the Early Elongation Complex R-HSA-113418 8.020067e-01 0.096 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 8.047323e-01 0.094 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 8.055087e-01 0.094 0 0
Germ layer formation at gastrulation R-HSA-9754189 8.055087e-01 0.094 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 8.055087e-01 0.094 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 8.055087e-01 0.094 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 8.055087e-01 0.094 0 0
Binding and entry of HIV virion R-HSA-173107 8.063901e-01 0.093 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 8.063901e-01 0.093 0 0
DNA replication initiation R-HSA-68952 8.063901e-01 0.093 0 0
Formation of intermediate mesoderm R-HSA-9761174 8.063901e-01 0.093 0 0
CASP4 inflammasome assembly R-HSA-9948001 8.063901e-01 0.093 0 0
Maturation of spike protein R-HSA-9683686 8.063901e-01 0.093 0 0
Diseases of DNA repair R-HSA-9675135 8.101641e-01 0.091 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 8.128301e-01 0.090 0 0
tRNA processing R-HSA-72306 8.139544e-01 0.089 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 8.173832e-01 0.088 0 0
mRNA Capping R-HSA-72086 8.173832e-01 0.088 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 8.173832e-01 0.088 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 8.183966e-01 0.087 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 8.183966e-01 0.087 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 8.232298e-01 0.084 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 8.232298e-01 0.084 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 8.232298e-01 0.084 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 8.267857e-01 0.083 0 0
DAG1 core M3 glycosylations R-HSA-8932505 8.293713e-01 0.081 0 0
Ionotropic activity of kainate receptors R-HSA-451306 8.293713e-01 0.081 0 0
Utilization of Ketone Bodies R-HSA-77108 8.293713e-01 0.081 0 0
Synthesis of PI R-HSA-1483226 8.293713e-01 0.081 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 8.293713e-01 0.081 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 8.293713e-01 0.081 0 0
Prostanoid ligand receptors R-HSA-391908 8.293713e-01 0.081 0 0
Dissolution of Fibrin Clot R-HSA-75205 8.293713e-01 0.081 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.311669e-01 0.080 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 8.317319e-01 0.080 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 8.317319e-01 0.080 0 0
Kidney development R-HSA-9830369 8.332730e-01 0.079 0 0
Metal ion SLC transporters R-HSA-425410 8.337709e-01 0.079 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.379102e-01 0.077 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 8.394857e-01 0.076 0 0
Lagging Strand Synthesis R-HSA-69186 8.394857e-01 0.076 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 8.394857e-01 0.076 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 8.431799e-01 0.074 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 8.431799e-01 0.074 0 0
Diseases of Immune System R-HSA-5260271 8.431799e-01 0.074 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 8.431799e-01 0.074 0 0
Mitochondrial protein degradation R-HSA-9837999 8.434509e-01 0.074 0 0
Amino acid transport across the plasma membrane R-HSA-352230 8.478230e-01 0.072 0 0
Integrin cell surface interactions R-HSA-216083 8.480656e-01 0.072 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.496259e-01 0.071 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 8.496259e-01 0.071 0 0
Plasmalogen biosynthesis R-HSA-75896 8.496259e-01 0.071 0 0
FMO oxidises nucleophiles R-HSA-217271 8.496259e-01 0.071 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.496259e-01 0.071 0 0
Interferon gamma signaling R-HSA-877300 8.497046e-01 0.071 0 0
Metabolism of amino acids and derivatives R-HSA-71291 8.518267e-01 0.070 0 0
Pyruvate metabolism R-HSA-70268 8.534518e-01 0.069 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 8.543745e-01 0.068 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 8.543745e-01 0.068 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 8.543745e-01 0.068 0 0
Mitochondrial calcium ion transport R-HSA-8949215 8.543745e-01 0.068 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 8.543745e-01 0.068 0 0
Glucocorticoid biosynthesis R-HSA-194002 8.543745e-01 0.068 0 0
Androgen biosynthesis R-HSA-193048 8.543745e-01 0.068 0 0
Ribavirin ADME R-HSA-9755088 8.543745e-01 0.068 0 0
RAB geranylgeranylation R-HSA-8873719 8.572357e-01 0.067 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 8.575363e-01 0.067 0 0
Inwardly rectifying K+ channels R-HSA-1296065 8.575363e-01 0.067 0 0
Repression of WNT target genes R-HSA-4641265 8.674772e-01 0.062 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.674772e-01 0.062 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 8.674772e-01 0.062 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 8.674772e-01 0.062 0 0
Estrogen biosynthesis R-HSA-193144 8.674772e-01 0.062 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.674772e-01 0.062 0 0
OAS antiviral response R-HSA-8983711 8.674772e-01 0.062 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 8.679916e-01 0.061 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 8.679916e-01 0.061 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 8.679916e-01 0.061 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 8.679916e-01 0.061 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 8.679916e-01 0.061 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 8.679916e-01 0.061 0 0
Activation of GABAB receptors R-HSA-991365 8.749703e-01 0.058 0 0
GABA B receptor activation R-HSA-977444 8.749703e-01 0.058 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 8.749703e-01 0.058 0 0
Post-translational protein phosphorylation R-HSA-8957275 8.796366e-01 0.056 0 0
Interleukin-20 family signaling R-HSA-8854691 8.804291e-01 0.055 0 0
Mitochondrial mRNA modification R-HSA-9937008 8.804291e-01 0.055 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.832102e-01 0.054 0 0
Microbial factors inhibit CASP4 activity R-HSA-9956593 8.832102e-01 0.054 0 0
Processing of SMDT1 R-HSA-8949664 8.832102e-01 0.054 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 8.832102e-01 0.054 0 0
FGFR1c ligand binding and activation R-HSA-190373 8.832102e-01 0.054 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 8.832102e-01 0.054 0 0
rRNA modification in the mitochondrion R-HSA-6793080 8.832102e-01 0.054 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.832102e-01 0.054 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.863436e-01 0.052 0 0
eNOS activation R-HSA-203615 8.897344e-01 0.051 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 8.897344e-01 0.051 0 0
Hyaluronan metabolism R-HSA-2142845 8.897344e-01 0.051 0 0
Thromboxane signalling through TP receptor R-HSA-428930 8.917750e-01 0.050 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 8.917750e-01 0.050 0 0
SLC transporter disorders R-HSA-5619102 8.924182e-01 0.049 0 0
Removal of the Flap Intermediate R-HSA-69166 8.970763e-01 0.047 0 0
Hydrolysis of LPC R-HSA-1483115 8.970763e-01 0.047 0 0
Beta oxidation of hexanoyl-CoA to butanoyl-CoA R-HSA-77350 8.970763e-01 0.047 0 0
Beta oxidation of octanoyl-CoA to hexanoyl-CoA R-HSA-77348 8.970763e-01 0.047 0 0
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA R-HSA-77310 8.970763e-01 0.047 0 0
Malate-aspartate shuttle R-HSA-9856872 8.970763e-01 0.047 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.970763e-01 0.047 0 0
Non-canonical inflammasome activation R-HSA-9686114 8.970763e-01 0.047 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.970763e-01 0.047 0 0
Mitochondrial biogenesis R-HSA-1592230 8.984903e-01 0.046 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 8.989221e-01 0.046 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 8.989221e-01 0.046 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 8.989221e-01 0.046 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.021132e-01 0.045 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.021132e-01 0.045 0 0
G protein gated Potassium channels R-HSA-1296059 9.021132e-01 0.045 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.021132e-01 0.045 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 9.021132e-01 0.045 0 0
Laminin interactions R-HSA-3000157 9.021132e-01 0.045 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.021132e-01 0.045 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.021132e-01 0.045 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.085802e-01 0.042 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.085802e-01 0.042 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 9.092967e-01 0.041 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 9.092967e-01 0.041 0 0
Processive synthesis on the lagging strand R-HSA-69183 9.092967e-01 0.041 0 0
Protein lipoylation R-HSA-9857492 9.092967e-01 0.041 0 0
Synthesis of 12-eicosatetraenoic acid derivatives R-HSA-2142712 9.092967e-01 0.041 0 0
Beta oxidation of butanoyl-CoA to acetyl-CoA R-HSA-77352 9.092967e-01 0.041 0 0
FASTK family proteins regulate processing and stability of mitochondrial RNAs R-HSA-9837092 9.092967e-01 0.041 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 9.092967e-01 0.041 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 9.092967e-01 0.041 0 0
Other semaphorin interactions R-HSA-416700 9.092967e-01 0.041 0 0
DNA Damage Reversal R-HSA-73942 9.092967e-01 0.041 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.104613e-01 0.041 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.108986e-01 0.041 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 9.115230e-01 0.040 0 0
Urea cycle R-HSA-70635 9.115230e-01 0.040 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.115230e-01 0.040 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 9.200669e-01 0.036 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 9.200669e-01 0.036 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 9.200669e-01 0.036 0 0
Killing mechanisms R-HSA-9664420 9.200669e-01 0.036 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 9.200669e-01 0.036 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.200669e-01 0.036 0 0
Activation of the phototransduction cascade R-HSA-2485179 9.200669e-01 0.036 0 0
Fructose catabolism R-HSA-70350 9.200669e-01 0.036 0 0
Attachment and Entry R-HSA-9678110 9.200669e-01 0.036 0 0
Mitochondrial Uncoupling R-HSA-166187 9.200669e-01 0.036 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.200790e-01 0.036 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.200790e-01 0.036 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 9.200790e-01 0.036 0 0
Triglyceride metabolism R-HSA-8979227 9.242095e-01 0.034 0 0
Telomere Extension By Telomerase R-HSA-171319 9.278513e-01 0.033 0 0
Insulin receptor recycling R-HSA-77387 9.278513e-01 0.033 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.278513e-01 0.033 0 0
Pyrimidine salvage R-HSA-73614 9.278513e-01 0.033 0 0
Signaling by ALK R-HSA-201556 9.291452e-01 0.032 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 9.291452e-01 0.032 0 0
Glycine degradation R-HSA-6783984 9.295587e-01 0.032 0 0
Fibronectin matrix formation R-HSA-1566977 9.295587e-01 0.032 0 0
Heme assimilation R-HSA-9927020 9.295587e-01 0.032 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 9.295587e-01 0.032 0 0
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA R-HSA-77346 9.295587e-01 0.032 0 0
Synthesis of PG R-HSA-1483148 9.295587e-01 0.032 0 0
Galactose catabolism R-HSA-70370 9.295587e-01 0.032 0 0
Coenzyme A biosynthesis R-HSA-196783 9.295587e-01 0.032 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 9.295587e-01 0.032 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.297230e-01 0.032 0 0
tRNA Aminoacylation R-HSA-379724 9.297230e-01 0.032 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.311199e-01 0.031 0 0
Azathioprine ADME R-HSA-9748787 9.339089e-01 0.030 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.339089e-01 0.030 0 0
Glucagon-type ligand receptors R-HSA-420092 9.349053e-01 0.029 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 9.379239e-01 0.028 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.379239e-01 0.028 0 0
Synthesis of 15-eicosatetraenoic acid derivatives R-HSA-2142770 9.379239e-01 0.028 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.379239e-01 0.028 0 0
Maturation of spike protein R-HSA-9694548 9.409142e-01 0.026 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.409142e-01 0.026 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.413020e-01 0.026 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.413020e-01 0.026 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 9.413020e-01 0.026 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.414470e-01 0.026 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 9.452961e-01 0.024 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.452961e-01 0.024 0 0
Polo-like kinase mediated events R-HSA-156711 9.452961e-01 0.024 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.452961e-01 0.024 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.460721e-01 0.024 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.460939e-01 0.024 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.470979e-01 0.024 0 0
Cargo concentration in the ER R-HSA-5694530 9.470979e-01 0.024 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.470979e-01 0.024 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.494112e-01 0.023 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 9.517932e-01 0.021 0 0
Specification of the neural plate border R-HSA-9834899 9.517932e-01 0.021 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 9.517932e-01 0.021 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.525390e-01 0.021 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.563869e-01 0.019 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.570934e-01 0.019 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.575189e-01 0.019 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.575189e-01 0.019 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.575189e-01 0.019 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.575189e-01 0.019 0 0
Pregnenolone biosynthesis R-HSA-196108 9.575189e-01 0.019 0 0
Synthesis of Ketone Bodies R-HSA-77111 9.575189e-01 0.019 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.579971e-01 0.019 0 0
Post-translational protein modification R-HSA-597592 9.583550e-01 0.018 0 0
Amine ligand-binding receptors R-HSA-375280 9.592060e-01 0.018 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.601279e-01 0.018 0 0
Formation of the cornified envelope R-HSA-6809371 9.603978e-01 0.018 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.613860e-01 0.017 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.613860e-01 0.017 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.613860e-01 0.017 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.613860e-01 0.017 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.625649e-01 0.017 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 9.625649e-01 0.017 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.625649e-01 0.017 0 0
Phenylalanine metabolism R-HSA-8964208 9.625649e-01 0.017 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 9.625649e-01 0.017 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.625649e-01 0.017 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.625649e-01 0.017 0 0
Synthesis of PA R-HSA-1483166 9.634212e-01 0.016 0 0
RA biosynthesis pathway R-HSA-5365859 9.652646e-01 0.015 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.652646e-01 0.015 0 0
G alpha (s) signalling events R-HSA-418555 9.661918e-01 0.015 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.662815e-01 0.015 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.664602e-01 0.015 0 0
Attachment and Entry R-HSA-9694614 9.670118e-01 0.015 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.670780e-01 0.015 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.687668e-01 0.014 0 0
Extension of Telomeres R-HSA-180786 9.692627e-01 0.014 0 0
Synthesis of PC R-HSA-1483191 9.692775e-01 0.014 0 0
Notch-HLH transcription pathway R-HSA-350054 9.709306e-01 0.013 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.709306e-01 0.013 0 0
Fructose metabolism R-HSA-5652084 9.709306e-01 0.013 0 0
Cellular hexose transport R-HSA-189200 9.709306e-01 0.013 0 0
GABA receptor activation R-HSA-977443 9.718451e-01 0.012 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.719275e-01 0.012 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.743842e-01 0.011 0 0
Interleukin receptor SHC signaling R-HSA-912526 9.743842e-01 0.011 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.743842e-01 0.011 0 0
Ketone body metabolism R-HSA-74182 9.743842e-01 0.011 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.743842e-01 0.011 0 0
Carnitine shuttle R-HSA-200425 9.743842e-01 0.011 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.743842e-01 0.011 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.745077e-01 0.011 0 0
Voltage gated Potassium channels R-HSA-1296072 9.747782e-01 0.011 0 0
Metabolism of folate and pterines R-HSA-196757 9.747782e-01 0.011 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.762841e-01 0.010 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 9.764119e-01 0.010 0 0
Heme signaling R-HSA-9707616 9.764119e-01 0.010 0 0
G alpha (q) signalling events R-HSA-416476 9.772230e-01 0.010 0 0
Elastic fibre formation R-HSA-1566948 9.773480e-01 0.010 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.774276e-01 0.010 0 0
Complex III assembly R-HSA-9865881 9.774276e-01 0.010 0 0
Adipogenesis R-HSA-9843745 9.774900e-01 0.010 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.786186e-01 0.009 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.790917e-01 0.009 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.801095e-01 0.009 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.811322e-01 0.008 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.817486e-01 0.008 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.817486e-01 0.008 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 9.824730e-01 0.008 0 0
Sphingolipid catabolism R-HSA-9845614 9.824730e-01 0.008 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.824730e-01 0.008 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.827548e-01 0.008 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.827548e-01 0.008 0 0
Nucleotide biosynthesis R-HSA-8956320 9.827975e-01 0.008 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 9.845557e-01 0.007 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 9.845557e-01 0.007 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.845557e-01 0.007 0 0
Metabolism of steroid hormones R-HSA-196071 9.849666e-01 0.007 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.849666e-01 0.007 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.850105e-01 0.007 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 9.853143e-01 0.006 0 0
Intra-Golgi traffic R-HSA-6811438 9.853143e-01 0.006 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.853143e-01 0.006 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.860158e-01 0.006 0 0
Prednisone ADME R-HSA-9757110 9.863911e-01 0.006 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.868330e-01 0.006 0 0
Thyroxine biosynthesis R-HSA-209968 9.880084e-01 0.005 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.880084e-01 0.005 0 0
Dectin-2 family R-HSA-5621480 9.884117e-01 0.005 0 0
COPII-mediated vesicle transport R-HSA-204005 9.885854e-01 0.005 0 0
Neurotransmitter clearance R-HSA-112311 9.894336e-01 0.005 0 0
ECM proteoglycans R-HSA-3000178 9.895948e-01 0.005 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.905103e-01 0.004 0 0
DAG1 glycosylations R-HSA-8931838 9.917962e-01 0.004 0 0
Potassium Channels R-HSA-1296071 9.924608e-01 0.003 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.927046e-01 0.003 0 0
Recycling of bile acids and salts R-HSA-159418 9.927714e-01 0.003 0 0
Heme degradation R-HSA-189483 9.936307e-01 0.003 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.945578e-01 0.002 0 0
Neurotransmitter release cycle R-HSA-112310 9.947483e-01 0.002 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.950552e-01 0.002 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.950552e-01 0.002 0 0
Complex IV assembly R-HSA-9864848 9.951324e-01 0.002 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.953342e-01 0.002 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.956431e-01 0.002 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.961612e-01 0.002 0 0
Phenylalanine and tyrosine metabolism R-HSA-8963691 9.961612e-01 0.002 0 0
Collagen chain trimerization R-HSA-8948216 9.961612e-01 0.002 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.966177e-01 0.001 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.966177e-01 0.001 0 0
Purine salvage R-HSA-74217 9.966177e-01 0.001 0 0
Extracellular matrix organization R-HSA-1474244 9.967110e-01 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.967706e-01 0.001 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.970199e-01 0.001 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.973743e-01 0.001 0 0
Tryptophan catabolism R-HSA-71240 9.973743e-01 0.001 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.979618e-01 0.001 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.982342e-01 0.001 0 0
Defensins R-HSA-1461973 9.984178e-01 0.001 0 0
Pyrimidine catabolism R-HSA-73621 9.984178e-01 0.001 0 0
Nucleotide salvage R-HSA-8956321 9.984239e-01 0.001 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.984791e-01 0.001 0 0
PI Metabolism R-HSA-1483255 9.985567e-01 0.001 0 0
Methylation R-HSA-156581 9.986060e-01 0.001 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.986060e-01 0.001 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.986413e-01 0.001 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.986631e-01 0.001 0 0
Interleukin-10 signaling R-HSA-6783783 9.986631e-01 0.001 0 0
G alpha (i) signalling events R-HSA-418594 9.987271e-01 0.001 0 0
Complex I biogenesis R-HSA-6799198 9.987450e-01 0.001 0 0
mitochondrial fatty acid beta-oxidation of saturated fatty acids R-HSA-77286 9.987719e-01 0.001 0 0
The canonical retinoid cycle in rods (twilight vision) R-HSA-2453902 9.987719e-01 0.001 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.987973e-01 0.001 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.989078e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.989790e-01 0.000 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.990467e-01 0.000 0 0
Collagen formation R-HSA-1474290 9.990764e-01 0.000 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.992601e-01 0.000 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.992601e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.992920e-01 0.000 0 0
PPARA activates gene expression R-HSA-1989781 9.993904e-01 0.000 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.994257e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.994375e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.994987e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.994987e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.994987e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.995781e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.996061e-01 0.000 1 0
Paracetamol ADME R-HSA-9753281 9.996541e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.996843e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.996953e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.997771e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.998016e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.998090e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.998145e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.998383e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.998383e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.998428e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.998610e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.998895e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999000e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999085e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999227e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.999335e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999450e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.999484e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999498e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999540e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.999545e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.999545e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999599e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999625e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.999647e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.999689e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999760e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.999813e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999913e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999917e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999940e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.999946e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999951e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999952e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999972e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999973e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999985e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999986e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999987e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999989e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999990e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999991e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999994e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999996e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999998e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999998e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999999e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999999e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways