WEE1

TYR version of PSPA with Y as phospho-acceptor
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
Y Sites Probabilities
Log-Odds: Y Sites / Y Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
A5A3E0 Y940 Sugiyama POTEF A26C1B ALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPEA
O15357 Y190 Sugiyama INPPL1 SHIP2 AAESAPNGLSTVSHDYLKGsyGLDLEAVRGGASHLPHLTRT
O43390 Y136 Sugiyama HNRNPR HNRPR QESTKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVY
O43615 Y201 Sugiyama TIMM44 MIMT44 TIM44 QGVEsVKKEIDDsVLGQtGPyRRPQRLRKRTEFAGDKFKEE
O43707 Y878 Sugiyama ACTN4 DKNFITAEELRRELPPDQAEyCIARMAPyQGPDAVPGALDy
O43852 Y263 Sugiyama CALU KNRDGKMDKEEtKDWILPsDyDHAEAEARHLVyEsDQNKDG
O43852 Y47 Sugiyama CALU RVHHEPQLsDKVHNDAQsFDyDHDAFLGAEEAKtFDQLtPE
O60361 Y136 Sugiyama NME2P1 SLRFKPEELVDYKSCAHDWVyE___________________
O60506 Y133 Sugiyama SYNCRIP HNRPQ NSAP1 ADSSKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVY
O60664 Y95 Sugiyama PLIN3 M6PRBP1 TIP47 VsGAQPILSKLEPQIAsAsEyAHRGLDKLEENLPILQQPTE
O60814 Y41 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK KAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKAMG
O60841 S186 Sugiyama EIF5B IF2 KIAA0741 EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
P00338 Y239 Sugiyama LDHA PIG19 GtDKDKEQWKEVHKQVVEsAyEVIKLKGYtSWAIGLSVADL
P00558 Y161 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 KAEPAKIEAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNL
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05787 Y282 Sugiyama KRT8 CYK8 EVKAQyEDIANRsRAEAEsMyQIKyEELQsLAGKHGDDLRR
P06493 T14 Sugiyama CDK1 CDC2 CDC28A CDKN1 P34CDC2 _______MEDyTKIEKIGEGtyGVVyKGRHKTTGQVVAMKK
P06493 Y15 SIGNOR|ELM|iPTMNet|EPSD|PSP CDK1 CDC2 CDC28A CDKN1 P34CDC2 ______MEDyTKIEKIGEGtyGVVyKGRHKTTGQVVAMKKI
P06730 Y197 Sugiyama EIF4E EIF4EL1 EIF4F THIGRVYKERLGLPPKIVIGyQsHADTAtKsGsttKNRFVV
P06733 Y189 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 MILPVGAANFREAMRIGAEVyHNLKNVIKEKyGKDAtNVGD
P06733 Y257 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 TDKVVIGMDVAASEFFRsGKyDLDFKsPDDPsRyIsPDQLA
P06733 Y270 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 EFFRsGKyDLDFKsPDDPsRyIsPDQLADLyKsFIKDyPVV
P06733 Y280 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 DFKsPDDPsRyIsPDQLADLyKsFIKDyPVVsIEDPFDQDD
P06733 Y44 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 LFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKGVSK
P07205 Y161 Sugiyama PGK2 PGKB KAEPDKIEAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNL
P07237 Y94 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB GSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFFRNGDTASPK
P07437 Y50 Sugiyama TUBB TUBB5 OK/SW-cl.56 IDPTGtyHGDsDLQLDRIsVyyNEAtGGKyVPRAILVDLEP
P07437 Y51 Sugiyama TUBB TUBB5 OK/SW-cl.56 DPTGtyHGDsDLQLDRIsVyyNEAtGGKyVPRAILVDLEPG
P07686 Y310 Sugiyama HEXB HCC7 DTPGHTLSWGKGQKDLLtPCySRQNKLDSFGPINPTLNTTY
P07711 Y330 Sugiyama CTSL CTSL1 GyVKMAKDRRNHCGIAsAAsyPtV_________________
P07814 Y827 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 EIGQNIssNssAsILESKsLyDEVAAQGEVVRKLKAEKSPK
P07900 Y284 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DEEEEKKDGDKKKKKKIKEKyIDQEELNKtKPIWtRNPDDI
P07900 Y313 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA tKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEG
P07900 Y38 EPSD|PSP HSP90AA1 HSP90A HSPC1 HSPCA ETFAFQAEIAQLMSLIINtFySNKEIFLRELIsNssDALDK
P07900 Y493 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA EMVsLKDYCTRMKENQKHIyyItGETKDQVANsAFVERLRK
P07900 Y61 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA KEIFLRELIsNssDALDKIRyEsLtDPsKLDsGKELHINLI
P08238 Y276 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DEEDDsGKDKKKKTKKIKEKyIDQEELNKtKPIWtRNPDDI
P08238 Y305 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB tKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEG
P08238 Y484 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DEMtsLsEyVsRMKEtQKsIyyItGEsKEQVANsAFVERVR
P08238 Y485 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB EMtsLsEyVsRMKEtQKsIyyItGEsKEQVANsAFVERVRK
P08238 Y56 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB KEIFLRELIsNAsDALDKIRyEsLtDPsKLDsGKELKIDII
P08758 Y91 Sugiyama ANXA5 ANX5 ENX2 PP4 SELTGKFEKLIVALMKPSRLyDAyELKHALKGAGTNEKVLt
P09104 Y44 Sugiyama ENO2 LyTAKGLFRAAVPsGAstGIyEALELRDGDKQRYLGKGVLK
P09651 Y341 Sugiyama HNRNPA1 HNRPA1 QSSNFGPMKGGNFGGRssGPyGGGGQyFAKPRNQGGyGGss
P09651 Y347 Sugiyama HNRNPA1 HNRPA1 PMKGGNFGGRssGPyGGGGQyFAKPRNQGGyGGssssssyG
P09960 Y233 Sugiyama LTA4H LTA4 RQIGPRTLVWSEKEQVEKSAyEFsETEsMLKIAEDLGGPYV
P0C7P4 Y100 Sugiyama UQCRFS1P1 UQCRFSL1 NVPASVCYSHTDIKVPDFSEyRRLEVLDSTKSSRESTEARK
P11142 Y41 Sugiyama HSPA8 HSC70 HSP73 HSPA10 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P11308 Y183 SIGNOR|PSP ERG IDGKELCKMTKDDFQRLtPSyNADILLSHLHYLRETPLPHL
P11940 Y297 Sugiyama PABPC1 PAB1 PABP PABP1 PABPC2 KRKFEQMKQDRITRyQGVNLyVKNLDDGIDDERLRKEFsPF
P12814 Y859 Sugiyama ACTN1 DKNyITMDELRRELPPDQAEyCIARMAPYTGPDSVPGALDY
P13010 Y316 Sugiyama XRCC5 G22P2 CLNDDDETEVLKEDIIQGFRyGsDIVPFSKVDEEQMKYKSE
P13667 Y137 Sugiyama PDIA4 ERP70 ERP72 VAKIDAtsAsVLAsRFDVsGyPtIKILKKGQAVDyEGsRtQ
P13674 Y282 Sugiyama P4HA1 P4HA ASDDQSDQKTTPKKKGVAVDyLPERQKyEMLCRGEGIKMTP
P13798 Y17 Sugiyama APEH D3F15S2 D3S48E DNF15S2 ____MERQVLLsEPEEAAALyRGLSRQPALsAACLGPEVtT
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P13929 Y44 Sugiyama ENO3 LHtAKGRFRAAVPsGAstGIyEALELRDGDKGRYLGKGVLK
P14625 Y401 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 VTFKSILFVPTSAPRGLFDEyGsKKSDYIKLYVRRVFITDD
P14625 Y677 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 NMERIMKAQAYQtGKDIstNyyAsQKKTFEINPRHPLIRDM
P14625 Y678 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 MERIMKAQAYQtGKDIstNyyAsQKKTFEINPRHPLIRDML
P15259 Y92 Sugiyama PGAM2 PGAMM DGTDQMWLPVVRTWRLNERHyGGLtGLNKAETAAKHGEEQV
P15328 Y82 Sugiyama FOLR1 FOLR KNACCSTNTSQEAHKDVsyLyRFNWNHCGEMAPACKRHFIQ
P17066 Y43 Sugiyama HSPA6 HSP70B' FQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAAL
P17987 Y545 Sugiyama TCP1 CCT1 CCTA LRIDDLIKLHPESKDDKHGsyEDAVHsGALND_________
P18615 Y133 Sugiyama NELFE RD RDBP sIsADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGEEA
P18621 Y4 Sugiyama RPL17 _________________MVRysLDPENPtKsCKSRGSNLRV
P18669 Y26 Sugiyama PGAM1 PGAMA CDABP0006 LVLIRHGEsAWNLENRFsGWyDADLsPAGHEEAKRGGQALR
P18669 Y92 Sugiyama PGAM1 PGAMA CDABP0006 DAIDQMWLPVVRTWRLNERHyGGLtGLNKAETAAKHGEAQV
P19338 Y462 Sugiyama NCL AEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNSTWs
P20618 Y150 Sugiyama PSMB1 PSC5 FPYYVYNIIGGLDEEGKGAVysFDPVGsyQRDsFKAGGSAS
P21333 Y1632 Sugiyama FLNA FLN FLN1 VTGRYTILIKYGGDEIPFsPyRVRAVPTGDASKCTVTVSIG
P21980 Y369 Sugiyama TGM2 PGYEGWQALDPTPQEKsEGtyCCGPVPVRAIKEGDLstKyD
P22234 Y22 Sugiyama PAICS ADE2 AIRC PAIS AtAEVLNIGKKLYEGKtKEVyELLDsPGKVLLQsKDQItAG
P22314 Y55 Sugiyama UBA1 A1S9T UBE1 SVPTNGMAKNGsEADIDEGLysRQLyVLGHEAMKRLQTSSV
P22392 Y151 Sugiyama NME2 NM23B SLWFKPEELVDyKSCAHDWVyE___________________
P22626 S225 Sugiyama HNRNPA2B1 HNRPA2B1 GNFGFGDsRGGGGNFGPGPGsNFRGGsDGyGsGRGFGDGyN
P22626 Y331 Sugiyama HNRNPA2B1 HNRPA2B1 SNYGPMKsGNFGGsRNMGGPyGGGNyGPGGsGGsGGyGGRs
P22626 Y336 Sugiyama HNRNPA2B1 HNRPA2B1 MKsGNFGGsRNMGGPyGGGNyGPGGsGGsGGyGGRsRy___
P22626 Y347 Sugiyama HNRNPA2B1 HNRPA2B1 MGGPyGGGNyGPGGsGGsGGyGGRsRy______________
P23284 Y119 Sugiyama PPIB CYPB DFMIQGGDFtRGDGtGGKsIyGERFPDENFKLKHyGPGWVs
P23434 Y139 Sugiyama GCSH EVTEINEALAENPGLVNKSCyEDGWLIKMtLsNPsELDELM
P23526 Y165 Sugiyama AHCY SAHH QLLPGIRGIsEEtTTGVHNLyKMMANGILKVPAINVNDsVt
P23526 Y193 Sugiyama AHCY SAHH LKVPAINVNDsVtKsKFDNLyGCRESLIDGIKRATDVMIAG
P23528 Y140 Sugiyama CFL1 CFL SKDAIKKKLtGIKHELQANCyEEVKDRCTLAEKLGGsAVIs
P24752 T220 Sugiyama ACAT1 ACAT MAT TAKKLNIARNEQDAyAINsytRSKAAWEAGKFGNEVIPVtV
P24752 Y214 Sugiyama ACAT1 ACAT MAT GsCAENTAKKLNIARNEQDAyAINsytRSKAAWEAGKFGNE
P24752 Y219 Sugiyama ACAT1 ACAT MAT NTAKKLNIARNEQDAyAINsytRSKAAWEAGKFGNEVIPVt
P24941 T14 EPSD|Sugiyama CDK2 CDKN2 _______MENFQKVEKIGEGtyGVVyKARNKLTGEVVALKK
P24941 Y15 SIGNOR|iPTMNet|EPSD|PSP CDK2 CDKN2 ______MENFQKVEKIGEGtyGVVyKARNKLTGEVVALKKI
P25398 Y127 Sugiyama RPS12 sCVVVKDYGKESQAKDVIEEyFKCKK_______________
P27348 Y149 Sugiyama YWHAQ LAEVACGDDRKQtIDNsQGAyQEAFDIsKKEMQPTHPIRLG
P27348 Y48 Sugiyama YWHAQ AVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSIEQK
P27695 Y45 Sugiyama APEX1 APE APE1 APEX APX HAP1 REF1 KSKTAAKKNDKEAAGEGPALyEDPPDQKtsPsGKPAtLKIC
P27797 Y109 Sugiyama CALR CRTC QTLVVQFTVKHEQNIDCGGGyVKLFPNSLDQTDMHGDSEYN
P29401 S308 Sugiyama TKT PPQEDAPsVDIANIRMPsLPsyKVGDKIATRKAYGQALAKL
P30041 Y89 Sugiyama PRDX6 AOP2 KIAA0106 IALSIDSVEDHLAWSKDINAyNCEEPtEKLPFPIIDDRNRE
P30043 T199 Sugiyama BLVRB FLR SCAN HDLGHFMLRCLttDEyDGHstyPsHQyQ_____________
P30101 Y100 Sugiyama PDIA3 ERP57 ERP60 GRP58 LAKVDCTANTNTCNKyGVsGyPtLKIFRDGEEAGAyDGPRt
P30101 Y115 Sugiyama PDIA3 ERP57 ERP60 GRP58 yGVsGyPtLKIFRDGEEAGAyDGPRtADGIVsHLKKQAGPA
P30291 S270 Sugiyama WEE1 QCRRRKRTyWNDSCGEDMEAsDyELEDETRPAKRITITESN
P30291 S293 Sugiyama WEE1 ELEDETRPAKRITITESNMKsRytTEFHELEKIGSGEFGsV
P30291 S444 Sugiyama WEE1 HMDIKPSNIFISRTSIPNAAsEEGDEDDWASNKVMFKIGDL
P30291 T173 iPTMNet|EPSD WEE1 GCGARRAGEGRRsPRPDHPGtPPHKTFRKLRLFDTPHtPKS
P30291 T296 Sugiyama WEE1 DETRPAKRITITESNMKsRytTEFHELEKIGSGEFGsVFKC
P30291 T615 Sugiyama WEE1 QKELKKAQMAKAAAEERALFtDRMATRSTTQSNRTSRLIGK
P30291 Y258 Sugiyama WEE1 FtPDsLLLHSSGQCRRRKRTyWNDSCGEDMEAsDyELEDET
P30291 Y272 Sugiyama WEE1 RRRKRTyWNDSCGEDMEAsDyELEDETRPAKRITITESNMK
P30291 Y295 Sugiyama WEE1 EDETRPAKRITITESNMKsRytTEFHELEKIGSGEFGsVFK
P30291 Y325 Sugiyama WEE1 IGSGEFGsVFKCVKRLDGCIyAIKRSKKPLAGSVDEQNALR
P31327 T166 Sugiyama CPS1 TKsLGQWLQEEKVPAIyGVDtRMLTKIIRDKGTMLGKIEFE
P31327 Y162 Sugiyama CPS1 HWLATKsLGQWLQEEKVPAIyGVDtRMLTKIIRDKGTMLGK
P31943 Y266 Sugiyama HNRNPH1 HNRPH HNRPH1 yNGYNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGstFQst
P31946 Y50 Sugiyama YWHAB AVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSIEQK
P31947 Y48 Sugiyama SFN HME1 GAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsIEQK
P31948 Y41 Sugiyama STIP1 DDALQCysEAIKLDPHNHVLysNRsAAyAKKGDYQKAyEDG
P32969 Y180 Sugiyama RPL9 OK/SW-cl.103; RPL9P7; RPL9P8; RPL9P9 LIQQATTVKNKDIRKFLDGIyVsEKGtVQQADE________
P34931 Y43 Sugiyama HSPA1L FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P37802 Y192 Sugiyama TAGLN2 KIAA0120 CDABP0035 NVIGLQMGtNRGAsQAGMtGyGMPRQIL_____________
P38646 Y118 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 ERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIK
P39019 Y54 Sugiyama RPS19 VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P40925 Y210 Sugiyama MDH1 MDHA tQYPDVNHAKVKLQGKEVGVyEALKDDsWLKGEFVttVQQR
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46777 Y226 Sugiyama RPL5 MSTP030 DyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAHAA
P47914 Y98 Sugiyama RPL29 PKEVKPKIPKGVSRKLDRLAyIAHPKLGKRARARIAKGLRL
P47985 Y91 Sugiyama UQCRFS1 NVPASVCYSHTDIKVPDFSEyRRLEVLDstKSSRESSEARK
P48643 Y274 Sugiyama CCT5 CCTE KIAA0098 PFEPPKPKTKHKLDVtsVEDyKALQKYEKEKFEEMIQQIKE
P48741 Y43 Sugiyama HSPA7 HSP70B FQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAAL
P49321 Y540 Sugiyama NASP DMLDLAKIIFKRQETKEAQLyAAQAHLKLGEVSVESENYVQ
P49327 S2032 Sugiyama FASN FAS ELDYFVVFSSVSCGRGNAGQsNyGFANsAMERICEKRRHEG
P49327 Y2034 Sugiyama FASN FAS DYFVVFSSVSCGRGNAGQsNyGFANsAMERICEKRRHEGLP
P49327 Y45 Sugiyama FASN FAS NLIGGVDMVTDDDRRWKAGLyGLPRRsGKLKDLSRFDAsFF
P50395 Y203 Sugiyama GDI2 RABGDIB DFTGHALALYRtDDyLDQPCyEtINRIKLYsEsLARYGKsP
P50502 Y185 Sugiyama ST13 AAG2 FAM10A1 HIP SNC6 NAAIRDCDRAIEINPDsAQPyKWRGKAHRLLGHWEEAAHDL
P50897 Y264 Sugiyama PPT1 CLN1 PPT FGFYRsGQAKEtIPLQEtsLytQDRLGLKEMDNAGQLVFLA
P50990 Y30 Sugiyama CCT8 C21orf112 CCTQ KIAA0002 GFAQMLKEGAKHFsGLEEAVyRNIQACKELAQTTRTAYGPN
P51858 S165 Sugiyama HDGF HMG1L2 AKEKNEKGALKRRAGDLLEDsPKRPKEAENPEGEEKEAAtL
P51991 S375 Sugiyama HNRNPA3 HNRPA3 ssGsPyGGGyGsGGGsGGyGsRRF_________________
P52789 S415 Sugiyama HK2 QRIKENKGEERLRstIGVDGsVyKKHPHFAKRLHKTVRRLV
P52789 Y417 Sugiyama HK2 IKENKGEERLRstIGVDGsVyKKHPHFAKRLHKTVRRLVPG
P54652 Y42 Sugiyama HSPA2 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P55795 Y266 Sugiyama HNRNPH2 FTP3 HNRPH2 YGGYNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGssFQst
P57053 Y41 Sugiyama H2BC12L H2BFS H2BS1 KAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssKAMG
P58876 Y41 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD KAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKAMG
P60174 Y209 Sugiyama TPI1 TPI LRGWLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDG
P60228 Y445 Sugiyama EIF3E EIF3S6 INT6 KLNQNSRSEAPNWAtQDsGFy____________________
P60660 Y86 Sugiyama MYL6 DFEHFLPMLQTVAKNKDQGtyEDyVEGLRVFDKEGNGtVMG
P60709 Y240 Sugiyama ACTB ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P60709 Y306 Sugiyama ACTB DVDIRKDLyANtVLsGGttMyPGIADRMQKEItALAPstMK
P60842 Y70 Sugiyama EIF4A1 DDX2A EIF4A yGFEKPsAIQQRAILPCIKGyDVIAQAQsGtGKTATFAISI
P61081 T176 Sugiyama UBE2M UBC12 NRRLFEQNVQRSMRGGyIGstyFERCLK_____________
P61081 Y172 Sugiyama UBE2M UBC12 VLQNNRRLFEQNVQRSMRGGyIGstyFERCLK_________
P61081 Y177 Sugiyama UBE2M UBC12 RRLFEQNVQRSMRGGyIGstyFERCLK______________
P61221 Y594 Sugiyama ABCE1 RLI RNASEL1 RNASELI RNS4I OK/SW-cl.40 RPRINKLNsIKDVEQKKsGNyFFLDD_______________
P61247 Y256 Sugiyama RPS3A FTE1 MFTL sssGKAtGDEtGAKVERADGyEPPVQEsV____________
P61247 Y31 Sugiyama RPS3A FTE1 MFTL KGGKKGAKKKVVDPFSKKDWyDVKAPAMFNIRNIGKTLVTR
P61353 Y85 Sugiyama RPL27 RSKIKSFVKVyNyNHLMPtRysVDIPLDKtVVNKDVFRDPA
P61978 Y323 Sugiyama HNRNPK HNRPK RARNLPLPPPPPPRGGDLMAyDRRGRPGDRYDGMVGFSADE
P61978 Y72 Sugiyama HNRNPK HNRPK KNAGAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISA
P61981 Y49 Sugiyama YWHAG NVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSIEQK
P62081 Y177 Sugiyama RPS7 HLDKAQQNNVEHKVEtFsGVyKKLTGKDVNFEFPEFQL___
P62249 Y115 Sugiyama RPS16 YYQKYVDEASKKEIKDILIQyDRtLLVADPRRCESKKFGGP
P62258 Y152 Sugiyama YWHAE LAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHPIRLG
P62258 Y49 Sugiyama YWHAE KVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssIEQK
P62263 Y72 Sugiyama RPS14 PRO2640 TICRVTGGMKVKADRDEssPyAAMLAAQDVAQRCKELGITA
P62269 Y95 Sugiyama RPS18 D6S218E RQYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLK
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62280 Y55 Sugiyama RPS11 RYYKNIGLGFKtPKEAIEGtyIDKKCPFTGNVsIRGRILsG
P62736 Y242 Sugiyama ACTA2 ACTSA ACTVS GIG46 ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P62807 Y41 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI KAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssKAMG
P62906 Y11 Sugiyama RPL10A NEDD6 __________MSSKVsRDtLyEAVREVLHGNQRKRRKFLET
P62917 Y133 Sugiyama RPL8 VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P63104 Y48 Sugiyama YWHAZ sVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssIEQK
P63261 Y240 Sugiyama ACTG1 ACTG ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P63261 Y306 Sugiyama ACTG1 ACTG DVDIRKDLyANtVLsGGttMyPGIADRMQKEItALAPstMK
P63267 Y241 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P67809 Y158 Sugiyama YBX1 NSEP1 YB1 YAADRNHYRRYPRRRGPPRNyQQNyQNsEsGEKNEGsEsAP
P67809 Y72 Sugiyama YBX1 NSEP1 YB1 KKVIATKVLGTVKWFNVRNGyGFINRNDtKEDVFVHQtAIK
P68032 Y242 Sugiyama ACTC1 ACTC ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68133 Y242 Sugiyama ACTA1 ACTA ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P83731 Y11 Sugiyama RPL24 __________MKVELCsFsGyKIYPGHGRRYARTDGKVFQF
Q00526 T14 Sugiyama CDK3 CDKN3 _______MDMFQKVEKIGEGtyGVVyKAKNRETGQLVALKK
Q00839 Y257 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 QKGGDKKRGVKRPREDHGRGyFEyIEENKysRAKsPQPPVE
Q02878 Y116 Sugiyama RPL6 TXREB1 VGGDKNGGTRVVKLRKMPRyyPtEDVPRKLLSHGKKPFSQH
Q04917 Y154 Sugiyama YWHAH YWHA1 LAEVASGEKKNsVVEAsEAAyKEAFEISKEQMQPTHPIRLG
Q04917 Y49 Sugiyama YWHAH YWHA1 AVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSIEQK
Q06830 Y116 Sugiyama PRDX1 PAGA PAGB TDPX2 GLGPMNIPLVSDPKRtIAQDyGVLKADEGIsFRGLFIIDDK
Q07866 Y474 Sugiyama KLC1 KLC KNS2 KACKVDsPtVTTtLKNLGALyRRQGKFEAAETLEEAAMRSR
Q08211 Y132 Sugiyama DHX9 DDX9 LKP NDH2 PLPPHLALKAENNsEVGAsGyGVPGPTWDRGANLKDYYSRK
Q14240 Y71 Sugiyama EIF4A2 DDX2B EIF4F yGFEKPsAIQQRAIIPCIKGyDVIAQAQsGtGKTATFAISI
Q14568 Y283 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 sDEEEEKKDGDKKKKKTKEKyIDQEELNKTKPIWTRNPDDI
Q14980 Y1836 Sugiyama NUMA1 NMP22 NUMA NITMTKKLDVEEPDsANssFystRsAPAsQAsLRAtsstQs
Q15293 Y278 Sugiyama RCN1 RCN LNKDGKLDKDEIRHWILPQDyDHAQAEARHLVyESDKNKDE
Q16658 Y493 Sugiyama FSCN1 FAN1 HSN SNL DHAGVLKASAEtVDPAsLWEy____________________
Q16719 Y47 Sugiyama KYNU ERVALHLDEEDKLRHFRECFyIPKIQDLPPVDLSLVNKDEN
Q1KMD3 Y215 Sugiyama HNRNPUL2 HNRPUL2 GERRGVKRQRDEKDEHGRAyyEFREEAYHsRsKsPLPPEEE
Q4VXU2 Y297 Sugiyama PABPC1L C20orf119 KRRFEQMKQDRLRRyQGVNLyVKNLDDSIDDDKLRKEFSPY
Q562R1 Y241 Sugiyama ACTBL2 ALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPEA
Q58FF3 Y58 Sugiyama HSP90B2P GRP94B GRP94P1 TRAP1 VTFKSILFVPTFVPRGLFDEyGsKKSDYIKLYVRCVFITDD
Q58FF6 Y32 Sugiyama HSP90AB4P KEIFLQELISNASDALDKIRyEsLtDPsKLDGGKELKIDII
Q58FF7 Y56 Sugiyama HSP90AB3P HSP90BC EEIFLQELISNASDALDKIRyEsLtDPsKLDsGKELKIDII
Q58FF8 Y198 Sugiyama HSP90AB2P HSP90BB DEEDDsGKDKKKKTKKIKEKyIDQEELNKTKPIWTRNTEDI
Q58FF8 Y260 Sugiyama HSP90AB2P HSP90BB VRYFSVEEYVSRMKEIQKsIyyItGEsKEQVANSAFVEQVW
Q58FF8 Y261 Sugiyama HSP90AB2P HSP90BB RYFSVEEYVSRMKEIQKsIyyItGEsKEQVANSAFVEQVWK
Q58FF8 Y56 Sugiyama HSP90AB2P HSP90BB KEIFLWELISNASDALDKIRyEsLtDPsKLDsGKELKIDII
Q58FG0 Y178 Sugiyama HSP90AA5P HSP90AE QLEELKDSRRVMKANQKHIyyItGETKDQVANSAFVECLQK
Q5QNW6 Y41 Sugiyama H2BC18 HIST2H2BF KVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKAMG
Q6PKG0 S774 Sugiyama LARP1 KIAA0731 LARP LFGAPEPstIARsLPttVPEsPNyRNtRtPRtPRtPQLKDS
Q6PKG0 Y777 Sugiyama LARP1 KIAA0731 LARP APEPstIARsLPttVPEsPNyRNtRtPRtPRtPQLKDSSQT
Q6S8J3 Y940 Sugiyama POTEE A26C1A POTE2 ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
Q7KZF4 Y476 Sugiyama SND1 TDRD11 SKGLATVIRYRQDDDQRssHyDELLAAEARAIKNGKGLHSK
Q8N0Y7 Y92 Sugiyama PGAM4 PGAM3 DAIDQMWLPVVRTWRLNERHyGGLtGLNKAETAAKHGEAQV
Q8NFI4 Y185 Sugiyama ST13P5 FAM10A5 NAAIQDCDRAIEINPDsAQPyKWRGKAHRLLGHWEEAAHDL
Q93052 Y301 Sugiyama LPP LQPEPGYGYAPNQGRyyEGyyAAGPGyGGRNDsDPtyGQQG
Q93079 Y41 Sugiyama H2BC9 H2BFJ HIST1H2BH KAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKAMG
Q96EA4 Y223 Sugiyama SPDL1 CCDC99 RQVDRLKEEKEEREKEAVSYyNALEKARVANQDLQVQLDQA
Q96G46 T273 Sugiyama DUS3L GAPRQENCGAQQVPAGPGtstPPssPVRtCGPLtDEDVVRL
Q99613 T880 Sugiyama EIF3C EIF3S8 AEKLGsLVENNERVFDHKQGtyGGyFRDQKDGYRKNEGYMR
Q99798 Y71 Sugiyama ACO2 NINIVRKRLNRPLTLSEKIVyGHLDDPAsQEIERGKSYLRL
Q99877 Y41 Sugiyama H2BC15 H2BFD HIST1H2BN KAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKAMG
Q99879 Y41 Sugiyama H2BC14 H2BFE HIST1H2BM KAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKAMG
Q99880 Y41 Sugiyama H2BC13 H2BFC HIST1H2BL KAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKAMG
Q9BQE3 Y449 Sugiyama TUBA1C TUBA6 EKDyEEVGADsADGEDEGEEy____________________
Q9BS26 Y395 Sugiyama ERP44 KIAA0573 TXNDC4 UNQ532/PRO1075 AQDVASSPPESSFQKLAPsEyRytLLRDRDEL_________
Q9BS26 Y397 Sugiyama ERP44 KIAA0573 TXNDC4 UNQ532/PRO1075 DVASSPPESSFQKLAPsEyRytLLRDRDEL___________
Q9BUJ2 Y111 Sugiyama HNRNPUL1 E1BAP5 HNRPUL1 GYSGPDGHYAMDNITRQNQFyDtQVIKQENESGyERRPLEM
Q9BUJ2 Y510 Sugiyama HNRNPUL1 E1BAP5 HNRPUL1 RLIQIAARKKRNyILDQtNVyGsAQRRKMRPFEGFQRKAIV
Q9BYX7 Y240 Sugiyama POTEKP ACTBL3 FKSG30 ALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPEA
Q9HB71 Y78 Sugiyama CACYBP S100A6BP SIP PNAS-107 EKPAAVVAPITTGytVKISNyGWDQSDKFVKIyITLTGVHQ
Q9NSK0 Y474 Sugiyama KLC4 KNSL8 KACKVssPTVNTTLRNLGALyRRQGKLEAAETLEECALRSR
Q9UBR2 Y76 Sugiyama CTSZ YLSPADLPKSWDWRNVDGVNyAsItRNQHIPQYCGSCWAHA
Q9UI15 Y192 Sugiyama TAGLN3 NP25 NVIGLQMGSNKGAsQAGMtGyGMPRQIM_____________
Q9Y2T7 Y107 Sugiyama YBX2 CSDA3 MSY2 KPVLAIQVLGTVKWFNVRNGyGFINRNDtKEDVFVHQtAIK
Q9Y3U8 Y53 Sugiyama RPL36 LTKHTKFVRDMIREVCGFAPyERRAMELLKVSKDKRALKFI
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 8.275147e-11 10.082 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.361955e-06 5.866 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.477042e-05 4.831 0 0
EPH-Ephrin signaling R-HSA-2682334 1.231121e-05 4.910 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 1.209229e-05 4.917 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.355647e-06 5.029 0 0
Axon guidance R-HSA-422475 6.517683e-06 5.186 0 0
Nervous system development R-HSA-9675108 1.569324e-05 4.804 0 0
Signaling by KIT in disease R-HSA-9669938 1.209229e-05 4.917 0 0
Signal Transduction R-HSA-162582 8.123661e-06 5.090 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.152518e-05 4.938 0 0
PECAM1 interactions R-HSA-210990 1.521140e-05 4.818 0 0
Cytokine Signaling in Immune system R-HSA-1280215 2.008556e-05 4.697 0 0
mRNA Splicing R-HSA-72172 2.334514e-05 4.632 0 0
Regulation of KIT signaling R-HSA-1433559 4.026391e-05 4.395 0 0
G2/M Transition R-HSA-69275 5.829195e-05 4.234 1 0
Mitotic G1 phase and G1/S transition R-HSA-453279 5.670473e-05 4.246 1 0
Mitotic G2-G2/M phases R-HSA-453274 6.312727e-05 4.200 1 0
Uptake and function of anthrax toxins R-HSA-5210891 8.703659e-05 4.060 0 0
Ephrin signaling R-HSA-3928664 1.031505e-04 3.987 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.032734e-04 3.986 0 0
Signaling by PTK6 R-HSA-8848021 1.032734e-04 3.986 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.152891e-04 3.938 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.119619e-04 3.951 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.417167e-04 3.849 0 0
Activation of TRKA receptors R-HSA-187015 1.632865e-04 3.787 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.832531e-04 3.737 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.897671e-04 3.722 0 0
Signaling by SCF-KIT R-HSA-1433557 2.006742e-04 3.698 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 2.832823e-04 3.548 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.907773e-04 3.536 0 0
MAPK3 (ERK1) activation R-HSA-110056 3.507533e-04 3.455 0 0
Gap junction trafficking and regulation R-HSA-157858 3.331711e-04 3.477 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 3.598707e-04 3.444 0 0
Cell Cycle, Mitotic R-HSA-69278 3.861822e-04 3.413 1 0
Intracellular signaling by second messengers R-HSA-9006925 3.938463e-04 3.405 0 0
MAPK family signaling cascades R-HSA-5683057 4.444656e-04 3.352 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 4.682005e-04 3.330 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 5.342093e-04 3.272 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 5.821860e-04 3.235 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 6.182448e-04 3.209 0 0
Separation of Sister Chromatids R-HSA-2467813 6.365195e-04 3.196 0 0
G0 and Early G1 R-HSA-1538133 6.824213e-04 3.166 0 0
G1/S Transition R-HSA-69206 6.605130e-04 3.180 1 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 7.741013e-04 3.111 0 0
Mitotic Anaphase R-HSA-68882 8.056870e-04 3.094 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 8.094355e-04 3.092 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 8.297585e-04 3.081 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.265067e-04 3.033 0 0
Interferon Signaling R-HSA-913531 1.018751e-03 2.992 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 1.211988e-03 2.917 0 0
TRKA activation by NGF R-HSA-187042 1.261246e-03 2.899 0 0
MET interacts with TNS proteins R-HSA-8875513 1.261246e-03 2.899 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.346687e-03 2.871 1 1
RAF/MAP kinase cascade R-HSA-5673001 1.431132e-03 2.844 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.503718e-03 2.823 1 1
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 1.589230e-03 2.799 0 0
Interleukin-2 family signaling R-HSA-451927 1.487439e-03 2.828 0 0
FLT3 Signaling R-HSA-9607240 1.605418e-03 2.794 0 0
Signaling by NTRKs R-HSA-166520 1.747009e-03 2.758 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.802435e-03 2.744 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 1.804033e-03 2.744 0 0
MTF1 activates gene expression R-HSA-5660489 1.804033e-03 2.744 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 2.142638e-03 2.669 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 2.280424e-03 2.642 0 0
Cyclin D associated events in G1 R-HSA-69231 2.142638e-03 2.669 0 0
G1 Phase R-HSA-69236 2.142638e-03 2.669 0 0
Regulation of signaling by CBL R-HSA-912631 2.032679e-03 2.692 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.289643e-03 2.640 0 0
Gap junction trafficking R-HSA-190828 2.142638e-03 2.669 0 0
NTRK2 activates RAC1 R-HSA-9032759 2.439061e-03 2.613 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 2.439061e-03 2.613 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 2.830170e-03 2.548 0 0
Co-stimulation by CD28 R-HSA-389356 2.792657e-03 2.554 0 0
Signaling by Interleukins R-HSA-449147 2.816362e-03 2.550 0 0
Degradation of CDH1 R-HSA-9766229 2.974063e-03 2.527 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 2.974063e-03 2.527 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 2.974063e-03 2.527 0 0
NGF-independant TRKA activation R-HSA-187024 3.164416e-03 2.500 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 3.164416e-03 2.500 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 3.133001e-03 2.504 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 3.432018e-03 2.464 0 0
Signaling by VEGF R-HSA-194138 3.414734e-03 2.467 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 3.164416e-03 2.500 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 3.133001e-03 2.504 0 0
Metabolism of RNA R-HSA-8953854 3.155918e-03 2.501 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 3.454994e-03 2.462 0 0
Growth hormone receptor signaling R-HSA-982772 3.454994e-03 2.462 0 0
Interleukin-20 family signaling R-HSA-8854691 3.454994e-03 2.462 0 0
Cell Cycle R-HSA-1640170 3.549593e-03 2.450 1 0
Uptake and actions of bacterial toxins R-HSA-5339562 3.566303e-03 2.448 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 3.796517e-03 2.421 0 0
Hemostasis R-HSA-109582 3.929656e-03 2.406 1 0
Erythropoietin activates STAT5 R-HSA-9027283 3.978211e-03 2.400 0 0
Nef and signal transduction R-HSA-164944 3.978211e-03 2.400 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 4.941719e-03 2.306 0 0
FCGR activation R-HSA-2029481 4.413145e-03 2.355 0 0
Regulation of CDH1 Function R-HSA-9764561 4.723093e-03 2.326 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 5.364728e-03 2.270 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 5.808866e-03 2.236 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 5.863729e-03 2.232 0 0
Interleukin-23 signaling R-HSA-9020933 5.863729e-03 2.232 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 5.863729e-03 2.232 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 5.900319e-03 2.229 0 0
Parasite infection R-HSA-9664407 5.900319e-03 2.229 0 0
Leishmania phagocytosis R-HSA-9664417 5.900319e-03 2.229 0 0
Mitotic Prometaphase R-HSA-68877 6.573806e-03 2.182 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 6.108765e-03 2.214 0 0
MAPK1 (ERK2) activation R-HSA-112411 6.931822e-03 2.159 0 0
Hedgehog 'off' state R-HSA-5610787 6.012465e-03 2.221 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 6.414986e-03 2.193 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 7.270706e-03 2.138 0 0
S Phase R-HSA-69242 7.653323e-03 2.116 1 0
Integrin signaling R-HSA-354192 7.801935e-03 2.108 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 7.801935e-03 2.108 1 1
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 7.801935e-03 2.108 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 8.081098e-03 2.093 0 0
Interleukin-27 signaling R-HSA-9020956 8.081098e-03 2.093 0 0
Cell-Cell communication R-HSA-1500931 8.209285e-03 2.086 0 0
Drug resistance of ALK mutants R-HSA-9700649 1.019454e-02 1.992 0 0
ASP-3026-resistant ALK mutants R-HSA-9717264 1.019454e-02 1.992 0 0
crizotinib-resistant ALK mutants R-HSA-9717326 1.019454e-02 1.992 0 0
NVP-TAE684-resistant ALK mutants R-HSA-9717301 1.019454e-02 1.992 0 0
alectinib-resistant ALK mutants R-HSA-9717316 1.019454e-02 1.992 0 0
brigatinib-resistant ALK mutants R-HSA-9717319 1.019454e-02 1.992 0 0
lorlatinib-resistant ALK mutants R-HSA-9717329 1.019454e-02 1.992 0 0
ceritinib-resistant ALK mutants R-HSA-9717323 1.019454e-02 1.992 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 8.931622e-03 2.049 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 9.236780e-03 2.034 0 0
Regulation of mitotic cell cycle R-HSA-453276 9.236780e-03 2.034 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 8.536623e-03 2.069 0 0
GPVI-mediated activation cascade R-HSA-114604 1.015222e-02 1.993 0 0
Immune System R-HSA-168256 9.369808e-03 2.028 0 0
Gap junction assembly R-HSA-190861 8.931622e-03 2.049 0 0
G1/S-Specific Transcription R-HSA-69205 1.015222e-02 1.993 0 0
Infectious disease R-HSA-5663205 8.773603e-03 2.057 0 0
Interferon alpha/beta signaling R-HSA-909733 1.102321e-02 1.958 0 0
Interleukin-12 signaling R-HSA-9020591 1.135530e-02 1.945 0 0
L1CAM interactions R-HSA-373760 1.136528e-02 1.944 0 0
MET promotes cell motility R-HSA-8875878 1.146506e-02 1.941 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 1.199870e-02 1.921 0 0
Interleukin-35 Signalling R-HSA-8984722 1.199870e-02 1.921 0 0
Regulation of IFNG signaling R-HSA-877312 1.199870e-02 1.921 0 0
Aggrephagy R-HSA-9646399 1.287129e-02 1.890 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.345552e-02 1.871 0 0
Signaling by MET R-HSA-6806834 1.325832e-02 1.878 0 0
CD28 dependent Vav1 pathway R-HSA-389359 1.345552e-02 1.871 0 0
Interleukin-6 signaling R-HSA-1059683 1.345552e-02 1.871 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 1.345552e-02 1.871 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.648838e-02 1.783 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.345552e-02 1.871 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 1.345552e-02 1.871 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 1.561574e-02 1.806 0 0
Disease R-HSA-1643685 1.333021e-02 1.875 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.437186e-02 1.842 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.325832e-02 1.878 0 0
PKR-mediated signaling R-HSA-9833482 1.325832e-02 1.878 0 0
Erythropoietin activates RAS R-HSA-9027284 1.658570e-02 1.780 0 0
DCC mediated attractive signaling R-HSA-418885 1.658570e-02 1.780 0 0
Cell surface interactions at the vascular wall R-HSA-202733 1.736435e-02 1.760 0 0
Interleukin-12 family signaling R-HSA-447115 1.764626e-02 1.753 0 0
Chaperonin-mediated protein folding R-HSA-390466 1.764626e-02 1.753 0 0
Post NMDA receptor activation events R-HSA-438064 1.764626e-02 1.753 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.765894e-02 1.753 0 0
Selective autophagy R-HSA-9663891 1.825099e-02 1.739 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.825585e-02 1.739 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 1.825585e-02 1.739 0 0
Prolonged ERK activation events R-HSA-169893 1.825585e-02 1.739 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 1.825585e-02 1.739 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.825585e-02 1.739 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 1.854067e-02 1.732 0 0
Apoptotic execution phase R-HSA-75153 1.854067e-02 1.732 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 2.028577e-02 1.693 0 0
Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) R-HSA-5619110 2.028577e-02 1.693 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.179846e-02 1.662 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 1.944648e-02 1.711 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 2.433750e-02 1.614 0 0
Regulation of RAS by GAPs R-HSA-5658442 2.230866e-02 1.652 0 0
Intraflagellar transport R-HSA-5620924 2.037641e-02 1.691 0 0
Orc1 removal from chromatin R-HSA-68949 2.433750e-02 1.614 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 2.538813e-02 1.595 0 0
Protein folding R-HSA-391251 2.146727e-02 1.668 0 0
M Phase R-HSA-68886 2.383469e-02 1.623 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.442723e-02 1.612 0 0
Cell Cycle Checkpoints R-HSA-69620 2.527052e-02 1.597 1 0
Regulation of PTEN stability and activity R-HSA-8948751 2.538813e-02 1.595 0 0
Recycling pathway of L1 R-HSA-437239 1.944648e-02 1.711 0 0
Signaling by Hippo R-HSA-2028269 2.179846e-02 1.662 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 2.366786e-02 1.626 0 0
Signaling by Hedgehog R-HSA-5358351 2.240877e-02 1.650 0 0
Response to metal ions R-HSA-5660526 1.999395e-02 1.699 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 2.014196e-02 1.696 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 2.646286e-02 1.577 0 0
FOXO-mediated transcription R-HSA-9614085 2.729564e-02 1.564 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 2.756167e-02 1.560 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 2.756167e-02 1.560 0 0
Negative regulation of MET activity R-HSA-6807004 2.759537e-02 1.559 0 0
Nephrin family interactions R-HSA-373753 2.759537e-02 1.559 0 0
Developmental Biology R-HSA-1266738 2.814860e-02 1.551 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 2.868453e-02 1.542 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.970206e-02 1.527 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 2.983139e-02 1.525 0 0
NTRK3 as a dependence receptor R-HSA-9603505 3.027473e-02 1.519 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 3.027473e-02 1.519 0 0
Response of endothelial cells to shear stress R-HSA-9860931 3.137406e-02 1.503 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 3.176481e-02 1.498 0 0
Platelet activation, signaling and aggregation R-HSA-76002 3.274469e-02 1.485 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 3.292349e-02 1.482 0 0
Signaling by ERBB2 R-HSA-1227986 3.341544e-02 1.476 0 0
Kinesins R-HSA-983189 3.341544e-02 1.476 0 0
NTF3 activates NTRK2 (TRKB) signaling R-HSA-9025046 4.016246e-02 1.396 0 0
NTF4 activates NTRK2 (TRKB) signaling R-HSA-9026357 4.016246e-02 1.396 0 0
BDNF activates NTRK2 (TRKB) signaling R-HSA-9024909 4.016246e-02 1.396 0 0
NTF3 activates NTRK3 signaling R-HSA-9034013 4.016246e-02 1.396 0 0
Defective ADA disrupts (deoxy)adenosine deamination R-HSA-9734735 4.016246e-02 1.396 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 4.994998e-02 1.301 0 0
PLC-gamma1 signalling R-HSA-167021 4.994998e-02 1.301 0 0
Signalling to STAT3 R-HSA-198745 4.994998e-02 1.301 0 0
MET activates PTPN11 R-HSA-8865999 4.994998e-02 1.301 0 0
Invadopodia formation R-HSA-8941237 4.994998e-02 1.301 0 0
Interleukin receptor SHC signaling R-HSA-912526 3.616488e-02 1.442 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 3.844797e-02 1.415 0 0
MET activates PTK2 signaling R-HSA-8874081 4.317356e-02 1.365 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 4.561346e-02 1.341 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 3.721326e-02 1.429 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 3.721326e-02 1.429 0 0
AURKA Activation by TPX2 R-HSA-8854518 4.122262e-02 1.385 0 0
Interleukin-6 family signaling R-HSA-6783589 3.844797e-02 1.415 0 0
Semaphorin interactions R-HSA-373755 3.721326e-02 1.429 0 0
MET activates STAT3 R-HSA-8875791 4.994998e-02 1.301 0 0
Insulin receptor recycling R-HSA-77387 4.810305e-02 1.318 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 4.810305e-02 1.318 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 4.544078e-02 1.343 0 0
Signaling by ALK in cancer R-HSA-9700206 3.488151e-02 1.457 0 0
TCR signaling R-HSA-202403 3.765573e-02 1.424 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 3.393671e-02 1.469 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 3.616488e-02 1.442 0 0
Interaction between L1 and Ankyrins R-HSA-445095 4.561346e-02 1.341 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 3.488151e-02 1.457 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 4.561346e-02 1.341 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 3.616488e-02 1.442 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 4.154681e-02 1.381 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 5.047485e-02 1.297 1 1
CD209 (DC-SIGN) signaling R-HSA-5621575 3.844797e-02 1.415 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 3.577748e-02 1.446 0 0
RNA Polymerase II Transcription R-HSA-73857 4.530761e-02 1.344 0 0
Leishmania parasite growth and survival R-HSA-9664433 4.869037e-02 1.313 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 4.869037e-02 1.313 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 4.888471e-02 1.311 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 4.836736e-02 1.315 0 0
Parasitic Infection Pathways R-HSA-9824443 3.643593e-02 1.438 0 0
Leishmania infection R-HSA-9658195 3.643593e-02 1.438 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 4.401171e-02 1.356 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 4.211639e-02 1.376 0 0
Apoptosis R-HSA-109581 3.877998e-02 1.411 0 0
Signaling by Erythropoietin R-HSA-9006335 5.064108e-02 1.295 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 5.138431e-02 1.289 0 0
Switching of origins to a post-replicative state R-HSA-69052 5.138431e-02 1.289 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 5.138431e-02 1.289 0 0
Generic Transcription Pathway R-HSA-212436 5.242581e-02 1.280 0 0
DAP12 signaling R-HSA-2424491 5.322632e-02 1.274 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 5.322632e-02 1.274 0 0
Centrosome maturation R-HSA-380287 5.449055e-02 1.264 0 0
Host Interactions of HIV factors R-HSA-162909 5.453646e-02 1.263 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 5.585756e-02 1.253 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 5.585756e-02 1.253 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 5.853360e-02 1.233 0 0
Diseases of mitotic cell cycle R-HSA-9675126 5.853360e-02 1.233 0 0
G2/M Checkpoints R-HSA-69481 5.930222e-02 1.227 1 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 5.931471e-02 1.227 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 5.963829e-02 1.224 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 5.963829e-02 1.224 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 5.963829e-02 1.224 0 0
Regulation of gap junction activity R-HSA-191650 5.963829e-02 1.224 0 0
MDK and PTN in ALK signaling R-HSA-9851151 5.963829e-02 1.224 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 5.963829e-02 1.224 0 0
IRS activation R-HSA-74713 6.922840e-02 1.160 0 0
G2 Phase R-HSA-68911 6.922840e-02 1.160 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 7.872129e-02 1.104 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 7.872129e-02 1.104 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 7.872129e-02 1.104 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 7.872129e-02 1.104 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 7.872129e-02 1.104 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 7.872129e-02 1.104 0 0
G2/M DNA replication checkpoint R-HSA-69478 8.811794e-02 1.055 1 1
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 8.811794e-02 1.055 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 9.741933e-02 1.011 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 9.741933e-02 1.011 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 9.741933e-02 1.011 0 0
IFNG signaling activates MAPKs R-HSA-9732724 9.741933e-02 1.011 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 9.741933e-02 1.011 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 1.066264e-01 0.972 0 0
Formation of annular gap junctions R-HSA-196025 1.066264e-01 0.972 0 0
MET receptor recycling R-HSA-8875656 1.066264e-01 0.972 0 0
ARMS-mediated activation R-HSA-170984 1.157401e-01 0.937 0 0
Interleukin-21 signaling R-HSA-9020958 1.157401e-01 0.937 0 0
Gap junction degradation R-HSA-190873 1.157401e-01 0.937 0 0
ALK mutants bind TKIs R-HSA-9700645 1.157401e-01 0.937 0 0
Voltage gated Potassium channels R-HSA-1296072 7.546623e-02 1.122 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 8.240198e-02 1.084 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.824899e-02 1.008 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.620439e-02 1.017 0 0
Signaling by RAF1 mutants R-HSA-9656223 9.060438e-02 1.043 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.065411e-01 0.972 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.065411e-01 0.972 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.065411e-01 0.972 0 0
PTK6 Down-Regulation R-HSA-8849472 6.922840e-02 1.160 0 0
Proteasome assembly R-HSA-9907900 1.000782e-01 1.000 0 0
Signaling by ALK R-HSA-201556 8.141780e-02 1.089 0 0
NGF-stimulated transcription R-HSA-9031628 1.131130e-01 0.946 0 0
MET Receptor Activation R-HSA-6806942 8.811794e-02 1.055 0 0
Signaling by RAS mutants R-HSA-6802949 1.065411e-01 0.972 0 0
Signalling to ERKs R-HSA-187687 6.966257e-02 1.157 0 0
Phosphorylation of Emi1 R-HSA-176417 7.872129e-02 1.104 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 1.065411e-01 0.972 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 6.954062e-02 1.158 0 0
Nucleotide salvage defects R-HSA-9734207 1.066264e-01 0.972 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.157401e-01 0.937 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 6.966257e-02 1.157 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 6.966257e-02 1.157 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.060438e-02 1.043 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 9.060438e-02 1.043 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 1.098138e-01 0.959 0 0
Cilium Assembly R-HSA-5617833 6.507298e-02 1.187 0 0
HIV Infection R-HSA-162906 1.114365e-01 0.953 0 0
DAP12 interactions R-HSA-2172127 1.000782e-01 1.000 0 0
Netrin-1 signaling R-HSA-373752 1.000782e-01 1.000 0 0
Degradation of DVL R-HSA-4641258 7.546623e-02 1.122 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 8.141780e-02 1.089 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 7.944779e-02 1.100 0 0
Reelin signalling pathway R-HSA-8866376 6.922840e-02 1.160 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 7.872129e-02 1.104 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 8.811794e-02 1.055 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 1.157401e-01 0.937 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 7.254539e-02 1.139 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 7.254539e-02 1.139 0 0
Degradation of AXIN R-HSA-4641257 7.546623e-02 1.122 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 7.546623e-02 1.122 0 0
Muscle contraction R-HSA-397014 9.157228e-02 1.038 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 1.087315e-01 0.964 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 7.872129e-02 1.104 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 9.741933e-02 1.011 0 0
Vpu mediated degradation of CD4 R-HSA-180534 6.401541e-02 1.194 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 6.681888e-02 1.175 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 6.681888e-02 1.175 0 0
Regulation of Apoptosis R-HSA-169911 6.966257e-02 1.157 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.060438e-02 1.043 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.060438e-02 1.043 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 9.824899e-02 1.008 0 0
Generation of second messenger molecules R-HSA-202433 8.444644e-02 1.073 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 6.966257e-02 1.157 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 8.444644e-02 1.073 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 8.750897e-02 1.058 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 8.750897e-02 1.058 0 0
COPI-mediated anterograde transport R-HSA-6807878 9.824899e-02 1.008 0 0
Cell junction organization R-HSA-446728 8.750181e-02 1.058 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 8.141780e-02 1.089 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.688998e-02 1.014 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 1.032956e-01 0.986 0 0
Potential therapeutics for SARS R-HSA-9679191 9.539701e-02 1.020 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 1.032956e-01 0.986 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.157401e-01 0.937 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 8.444644e-02 1.073 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 8.750897e-02 1.058 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 1.032956e-01 0.986 0 0
Macroautophagy R-HSA-1632852 8.049106e-02 1.094 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 1.231600e-01 0.910 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 1.032956e-01 0.986 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 1.032956e-01 0.986 0 0
Cardiac conduction R-HSA-5576891 6.556174e-02 1.183 0 0
Viral Infection Pathways R-HSA-9824446 8.113139e-02 1.091 0 0
Autophagy R-HSA-9612973 1.049224e-01 0.979 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 1.231600e-01 0.910 0 0
Downstream TCR signaling R-HSA-202424 8.240198e-02 1.084 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.017820e-02 1.045 0 0
RSV-host interactions R-HSA-9833110 1.174163e-01 0.930 0 0
Gene expression (Transcription) R-HSA-74160 1.154999e-01 0.937 0 0
PTEN Regulation R-HSA-6807070 7.766021e-02 1.110 0 0
Stabilization of p53 R-HSA-69541 8.141780e-02 1.089 0 0
Hedgehog ligand biogenesis R-HSA-5358346 1.231600e-01 0.910 0 0
Somitogenesis R-HSA-9824272 1.032956e-01 0.986 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 7.131783e-02 1.147 0 0
MITF-M-dependent gene expression R-HSA-9856651 9.539701e-02 1.020 0 0
Regulation of TP53 Degradation R-HSA-6804757 7.254539e-02 1.139 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.131130e-01 0.946 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 7.488060e-02 1.126 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 8.141780e-02 1.089 0 0
Programmed Cell Death R-HSA-5357801 8.298894e-02 1.081 0 0
Synthesis of DNA R-HSA-69239 1.240950e-01 0.906 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.247614e-01 0.904 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.247614e-01 0.904 0 0
PI3K/AKT activation R-HSA-198203 1.247614e-01 0.904 0 0
Signaling by Leptin R-HSA-2586552 1.247614e-01 0.904 0 0
Regulation of CDH11 function R-HSA-9762292 1.247614e-01 0.904 0 0
Signal attenuation R-HSA-74749 1.247614e-01 0.904 0 0
ESR-mediated signaling R-HSA-8939211 1.257464e-01 0.901 0 0
mRNA 3'-end processing R-HSA-72187 1.265560e-01 0.898 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 1.265560e-01 0.898 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.286229e-01 0.891 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 1.299743e-01 0.886 0 0
Neuronal System R-HSA-112316 1.312394e-01 0.882 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 1.323119e-01 0.878 0 0
Adaptive Immune System R-HSA-1280218 1.335591e-01 0.874 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 1.336913e-01 0.874 0 0
Interleukin-2 signaling R-HSA-9020558 1.336913e-01 0.874 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.359266e-01 0.867 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.359266e-01 0.867 0 0
Signaling by NOTCH3 R-HSA-9012852 1.368741e-01 0.864 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 1.425305e-01 0.846 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 1.425305e-01 0.846 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.425305e-01 0.846 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 1.425305e-01 0.846 0 0
Cellular responses to stimuli R-HSA-8953897 1.435253e-01 0.843 0 0
Dectin-2 family R-HSA-5621480 1.438532e-01 0.842 0 0
Respiratory electron transport R-HSA-611105 1.451368e-01 0.838 0 0
Cell-cell junction organization R-HSA-421270 1.471208e-01 0.832 0 0
MET activates RAS signaling R-HSA-8851805 1.512801e-01 0.820 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 1.512801e-01 0.820 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 1.512801e-01 0.820 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.512801e-01 0.820 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 1.512801e-01 0.820 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.512801e-01 0.820 0 0
Signaling by LTK R-HSA-9842663 1.512801e-01 0.820 0 0
OAS antiviral response R-HSA-8983711 1.512801e-01 0.820 0 0
Metabolism of polyamines R-HSA-351202 1.544574e-01 0.811 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 1.580254e-01 0.801 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.580254e-01 0.801 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 1.580254e-01 0.801 0 0
Formation of paraxial mesoderm R-HSA-9793380 1.580254e-01 0.801 0 0
Frs2-mediated activation R-HSA-170968 1.599410e-01 0.796 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 1.599410e-01 0.796 0 0
Diseases of nucleotide metabolism R-HSA-9735804 1.599410e-01 0.796 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.599410e-01 0.796 1 1
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 1.599410e-01 0.796 0 0
NCAM signaling for neurite out-growth R-HSA-375165 1.616089e-01 0.792 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.616089e-01 0.792 0 0
Complex I biogenesis R-HSA-6799198 1.652072e-01 0.782 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 1.652072e-01 0.782 0 0
MHC class II antigen presentation R-HSA-2132295 1.667956e-01 0.778 0 0
Prolactin receptor signaling R-HSA-1170546 1.685140e-01 0.773 0 0
CRMPs in Sema3A signaling R-HSA-399956 1.685140e-01 0.773 0 0
Retrograde neurotrophin signalling R-HSA-177504 1.685140e-01 0.773 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 1.685140e-01 0.773 0 0
Formation of the active cofactor, UDP-glucuronate R-HSA-173599 1.685140e-01 0.773 0 0
Signal regulatory protein family interactions R-HSA-391160 1.685140e-01 0.773 0 0
IGF1R signaling cascade R-HSA-2428924 1.688196e-01 0.773 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 1.721535e-01 0.764 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.724455e-01 0.763 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 1.724455e-01 0.763 0 0
Cellular response to hypoxia R-HSA-1234174 1.724455e-01 0.763 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.724455e-01 0.763 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.770001e-01 0.752 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.770001e-01 0.752 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 1.770001e-01 0.752 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.770001e-01 0.752 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.770001e-01 0.752 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.801775e-01 0.744 0 0
Phosphorylation of the APC/C R-HSA-176412 1.854000e-01 0.732 0 0
Atorvastatin ADME R-HSA-9754706 1.854000e-01 0.732 0 0
Co-inhibition by PD-1 R-HSA-389948 1.883251e-01 0.725 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.883251e-01 0.725 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 1.907548e-01 0.720 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 1.907548e-01 0.720 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 1.937148e-01 0.713 0 0
Synthesis of PG R-HSA-1483148 1.937148e-01 0.713 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 1.937148e-01 0.713 0 0
Hedgehog 'on' state R-HSA-5632684 1.944484e-01 0.711 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.947362e-01 0.711 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.981511e-01 0.703 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.981511e-01 0.703 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.018625e-01 0.695 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 2.019452e-01 0.695 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 2.019452e-01 0.695 0 0
Signaling by NOTCH4 R-HSA-9013694 2.055820e-01 0.687 0 0
Polo-like kinase mediated events R-HSA-156711 2.100920e-01 0.678 1 1
Platelet sensitization by LDL R-HSA-432142 2.100920e-01 0.678 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.100920e-01 0.678 0 0
UCH proteinases R-HSA-5689603 2.130429e-01 0.672 0 0
Ribosome-associated quality control R-HSA-9948299 2.130832e-01 0.671 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 2.155779e-01 0.666 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.177188e-01 0.662 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 2.181562e-01 0.661 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.181562e-01 0.661 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 2.181562e-01 0.661 0 0
E2F mediated regulation of DNA replication R-HSA-113510 2.181562e-01 0.661 0 0
Other interleukin signaling R-HSA-449836 2.181562e-01 0.661 0 0
ABC transporter disorders R-HSA-5619084 2.205297e-01 0.657 0 0
PCP/CE pathway R-HSA-4086400 2.205297e-01 0.657 0 0
Neutrophil degranulation R-HSA-6798695 2.206328e-01 0.656 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 2.210594e-01 0.655 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.261386e-01 0.646 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 2.264105e-01 0.645 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.280383e-01 0.642 0 0
Adherens junctions interactions R-HSA-418990 2.285095e-01 0.641 0 0
FCERI mediated NF-kB activation R-HSA-2871837 2.317867e-01 0.635 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.325662e-01 0.633 0 0
Signalling to RAS R-HSA-167044 2.340400e-01 0.631 0 0
Basigin interactions R-HSA-210991 2.340400e-01 0.631 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 2.355648e-01 0.628 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.355648e-01 0.628 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 2.393335e-01 0.621 0 0
ER to Golgi Anterograde Transport R-HSA-199977 2.398946e-01 0.620 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 2.418611e-01 0.616 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 2.418611e-01 0.616 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.418611e-01 0.616 0 0
Ribavirin ADME R-HSA-9755088 2.418611e-01 0.616 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 2.431052e-01 0.614 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.468796e-01 0.608 0 0
Meiosis R-HSA-1500620 2.468796e-01 0.608 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.468796e-01 0.608 0 0
FGFR2 alternative splicing R-HSA-6803529 2.496029e-01 0.603 0 0
SARS-CoV-2-host interactions R-HSA-9705683 2.504783e-01 0.601 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.506561e-01 0.601 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.506561e-01 0.601 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 2.506561e-01 0.601 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 2.535114e-01 0.596 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 2.535114e-01 0.596 0 0
XBP1(S) activates chaperone genes R-HSA-381038 2.544344e-01 0.594 0 0
DNA Replication R-HSA-69306 2.562486e-01 0.591 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 2.572661e-01 0.590 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 2.572661e-01 0.590 0 0
Organic anion transport by SLCO transporters R-HSA-879518 2.572661e-01 0.590 0 0
Mitochondrial mRNA modification R-HSA-9937008 2.572661e-01 0.590 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.572661e-01 0.590 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.648516e-01 0.577 0 0
Mitochondrial RNA degradation R-HSA-9836573 2.648516e-01 0.577 0 0
Complex III assembly R-HSA-9865881 2.648516e-01 0.577 0 0
ER-Phagosome pathway R-HSA-1236974 2.657753e-01 0.575 0 0
Organelle biogenesis and maintenance R-HSA-1852241 2.704531e-01 0.568 0 0
Sema4D in semaphorin signaling R-HSA-400685 2.723600e-01 0.565 0 0
Tight junction interactions R-HSA-420029 2.723600e-01 0.565 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 2.723600e-01 0.565 0 0
Interferon gamma signaling R-HSA-877300 2.727535e-01 0.564 0 0
IRE1alpha activates chaperones R-HSA-381070 2.771169e-01 0.557 0 0
Signaling by NOTCH R-HSA-157118 2.774014e-01 0.557 0 0
Signaling by Insulin receptor R-HSA-74752 2.808958e-01 0.551 0 0
Assembly of the pre-replicative complex R-HSA-68867 2.846733e-01 0.546 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.871489e-01 0.542 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.871489e-01 0.542 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 2.871489e-01 0.542 0 0
Disorders of transmembrane transporters R-HSA-5619115 2.933248e-01 0.533 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 2.944309e-01 0.531 0 0
Formation of the Early Elongation Complex R-HSA-113418 2.944309e-01 0.531 0 0
HIV elongation arrest and recovery R-HSA-167287 2.944309e-01 0.531 0 0
Pausing and recovery of HIV elongation R-HSA-167290 2.944309e-01 0.531 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 2.944309e-01 0.531 0 0
Telomere Extension By Telomerase R-HSA-171319 2.944309e-01 0.531 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 2.944309e-01 0.531 0 0
Potassium Channels R-HSA-1296071 2.997615e-01 0.523 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 2.997615e-01 0.523 0 0
mRNA Capping R-HSA-72086 3.016390e-01 0.521 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 3.016390e-01 0.521 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.016390e-01 0.521 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 3.035264e-01 0.518 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 3.035264e-01 0.518 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 3.060630e-01 0.514 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 3.087739e-01 0.510 0 0
Activation of the pre-replicative complex R-HSA-68962 3.087739e-01 0.510 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 3.087739e-01 0.510 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 3.087739e-01 0.510 0 0
Innate Immune System R-HSA-168249 3.090471e-01 0.510 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 3.116378e-01 0.506 0 0
Deubiquitination R-HSA-5688426 3.116678e-01 0.506 0 0
Ub-specific processing proteases R-HSA-5689880 3.144265e-01 0.502 0 0
Mitotic Spindle Checkpoint R-HSA-69618 3.147990e-01 0.502 0 0
ABC-family proteins mediated transport R-HSA-382556 3.147990e-01 0.502 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 3.158363e-01 0.501 0 0
Downstream signal transduction R-HSA-186763 3.158363e-01 0.501 0 0
Interleukin-1 signaling R-HSA-9020702 3.185480e-01 0.497 0 0
HS-GAG degradation R-HSA-2024096 3.228271e-01 0.491 0 0
Activation of ATR in response to replication stress R-HSA-176187 3.297468e-01 0.482 0 0
Nuclear RNA decay R-HSA-9930044 3.297468e-01 0.482 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 3.297468e-01 0.482 0 0
Recycling of bile acids and salts R-HSA-159418 3.297468e-01 0.482 0 0
Striated Muscle Contraction R-HSA-390522 3.365962e-01 0.473 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 3.365962e-01 0.473 0 0
Heme degradation R-HSA-189483 3.365962e-01 0.473 0 0
Mitophagy R-HSA-5205647 3.433760e-01 0.464 0 0
RAF activation R-HSA-5673000 3.433760e-01 0.464 0 0
Antigen processing-Cross presentation R-HSA-1236975 3.483461e-01 0.458 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 3.500870e-01 0.456 0 0
Signaling by Nuclear Receptors R-HSA-9006931 3.562133e-01 0.448 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 3.562533e-01 0.448 0 0
PRC2 methylates histones and DNA R-HSA-212300 3.567298e-01 0.448 0 0
RUNX2 regulates bone development R-HSA-8941326 3.567298e-01 0.448 0 0
FGFR2 mutant receptor activation R-HSA-1839126 3.567298e-01 0.448 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 3.630879e-01 0.440 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 3.630879e-01 0.440 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 3.633051e-01 0.440 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 3.633051e-01 0.440 0 0
Ovarian tumor domain proteases R-HSA-5689896 3.633051e-01 0.440 0 0
Purine salvage R-HSA-74217 3.698136e-01 0.432 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 3.698136e-01 0.432 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 3.741140e-01 0.427 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 3.762560e-01 0.425 0 0
HCMV Early Events R-HSA-9609690 3.784553e-01 0.422 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 3.813374e-01 0.419 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 3.826329e-01 0.417 0 0
HIV Transcription Elongation R-HSA-167169 3.826329e-01 0.417 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 3.826329e-01 0.417 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 3.826329e-01 0.417 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 3.826329e-01 0.417 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 3.826329e-01 0.417 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 3.889450e-01 0.410 0 0
PKMTs methylate histone lysines R-HSA-3214841 3.889450e-01 0.410 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 3.950066e-01 0.403 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 3.951930e-01 0.403 0 0
HIV Transcription Initiation R-HSA-167161 3.951930e-01 0.403 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 3.951930e-01 0.403 0 0
MAP2K and MAPK activation R-HSA-5674135 3.951930e-01 0.403 0 0
Signaling by ROBO receptors R-HSA-376176 3.977547e-01 0.400 0 0
Chromosome Maintenance R-HSA-73886 4.029413e-01 0.395 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 4.029413e-01 0.395 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 4.074990e-01 0.390 0 0
Bacterial Infection Pathways R-HSA-9824439 4.128986e-01 0.384 0 0
Surfactant metabolism R-HSA-5683826 4.135584e-01 0.383 0 0
RMTs methylate histone arginines R-HSA-3214858 4.135584e-01 0.383 0 0
Formation of the cornified envelope R-HSA-6809371 4.136106e-01 0.383 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 4.195561e-01 0.377 0 0
Nucleosome assembly R-HSA-774815 4.195561e-01 0.377 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 4.195561e-01 0.377 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 4.254929e-01 0.371 0 0
Platelet degranulation R-HSA-114608 4.276889e-01 0.369 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 4.313694e-01 0.365 0 0
Gluconeogenesis R-HSA-70263 4.371861e-01 0.359 0 0
Reproduction R-HSA-1474165 4.415898e-01 0.355 0 0
Adipogenesis R-HSA-9843745 4.450363e-01 0.352 0 0
Circadian clock R-HSA-9909396 4.484711e-01 0.348 0 0
Signaling by FGFR2 in disease R-HSA-5655253 4.486426e-01 0.348 0 0
Neddylation R-HSA-8951664 4.492301e-01 0.348 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 4.518940e-01 0.345 0 0
Complex IV assembly R-HSA-9864848 4.542837e-01 0.343 0 0
Meiotic recombination R-HSA-912446 4.542837e-01 0.343 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 4.598673e-01 0.337 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 4.653942e-01 0.332 0 0
Meiotic synapsis R-HSA-1221632 4.653942e-01 0.332 0 0
Smooth Muscle Contraction R-HSA-445355 4.653942e-01 0.332 0 0
Estrogen-dependent gene expression R-HSA-9018519 4.654647e-01 0.332 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 4.654647e-01 0.332 0 0
Transmission across Chemical Synapses R-HSA-112315 4.676978e-01 0.330 0 0
Glucuronidation R-HSA-156588 4.708649e-01 0.327 0 0
Unfolded Protein Response (UPR) R-HSA-381119 4.755128e-01 0.323 0 0
rRNA processing R-HSA-72312 4.782313e-01 0.320 0 0
Ion homeostasis R-HSA-5578775 4.816399e-01 0.317 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 4.816399e-01 0.317 0 0
Nuclear Envelope Breakdown R-HSA-2980766 4.869453e-01 0.313 0 0
Synthesis of PA R-HSA-1483166 4.869453e-01 0.313 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 4.973948e-01 0.303 0 0
Extension of Telomeres R-HSA-180786 4.973948e-01 0.303 0 0
Amino acid transport across the plasma membrane R-HSA-352230 4.973948e-01 0.303 0 0
Cellular responses to stress R-HSA-2262752 4.999004e-01 0.301 0 0
Regulation of PTEN gene transcription R-HSA-8943724 5.025399e-01 0.299 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 5.072927e-01 0.295 0 0
Viral Messenger RNA Synthesis R-HSA-168325 5.076327e-01 0.294 0 0
Nucleotide salvage R-HSA-8956321 5.076327e-01 0.294 0 0
Gastrulation R-HSA-9758941 5.113620e-01 0.291 0 0
Mitochondrial protein import R-HSA-1268020 5.126736e-01 0.290 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 5.126736e-01 0.290 0 0
Signaling by PDGF R-HSA-186797 5.126736e-01 0.290 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 5.177070e-01 0.286 0 0
Interleukin-1 family signaling R-HSA-446652 5.208591e-01 0.283 0 0
Insulin receptor signalling cascade R-HSA-74751 5.226021e-01 0.282 0 0
CD22 mediated BCR regulation R-HSA-5690714 5.226021e-01 0.282 0 0
HCMV Infection R-HSA-9609646 5.240985e-01 0.281 0 0
SARS-CoV-2 Infection R-HSA-9694516 5.244749e-01 0.280 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 5.302332e-01 0.276 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 5.323295e-01 0.274 0 0
SLC-mediated transport of amino acids R-HSA-9958863 5.371191e-01 0.270 0 0
SARS-CoV Infections R-HSA-9679506 5.411395e-01 0.267 0 0
Transcription of the HIV genome R-HSA-167172 5.418599e-01 0.266 0 0
Signaling by TGFB family members R-HSA-9006936 5.455797e-01 0.263 0 0
Regulation of TP53 Activity R-HSA-5633007 5.455797e-01 0.263 0 0
Metabolism of porphyrins R-HSA-189445 5.557948e-01 0.255 0 0
Developmental Cell Lineages R-HSA-9734767 5.558303e-01 0.255 0 0
SLC transporter disorders R-HSA-5619102 5.664757e-01 0.247 0 0
Cellular response to chemical stress R-HSA-9711123 5.676981e-01 0.246 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 5.693083e-01 0.245 0 0
G2/M DNA damage checkpoint R-HSA-69473 5.693083e-01 0.245 1 0
Signaling by ERBB4 R-HSA-1236394 5.693083e-01 0.245 0 0
Signaling by FGFR in disease R-HSA-1226099 5.693083e-01 0.245 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 5.737213e-01 0.241 0 0
Interleukin-10 signaling R-HSA-6783783 5.866926e-01 0.232 0 0
Integrin cell surface interactions R-HSA-216083 5.866926e-01 0.232 0 0
SLC-mediated transport of organic anions R-HSA-9955298 5.866926e-01 0.232 0 0
Signaling by FGFR2 R-HSA-5654738 5.951215e-01 0.225 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 5.960466e-01 0.225 0 0
Processing of DNA double-strand break ends R-HSA-5693607 5.992716e-01 0.222 0 0
Influenza Infection R-HSA-168255 6.034350e-01 0.219 0 0
Cellular Senescence R-HSA-2559583 6.061780e-01 0.217 0 0
Cytoprotection by HMOX1 R-HSA-9707564 6.074454e-01 0.216 0 0
TCF dependent signaling in response to WNT R-HSA-201681 6.143214e-01 0.212 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 6.232991e-01 0.205 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 6.232991e-01 0.205 0 0
Peptide chain elongation R-HSA-156902 6.309857e-01 0.200 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 6.422241e-01 0.192 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 6.458942e-01 0.190 0 0
Eukaryotic Translation Elongation R-HSA-156842 6.495268e-01 0.187 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 6.602039e-01 0.180 0 0
Eukaryotic Translation Termination R-HSA-72764 6.636906e-01 0.178 0 0
Formation of a pool of free 40S subunits R-HSA-72689 6.636906e-01 0.178 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 6.671417e-01 0.176 0 0
Telomere Maintenance R-HSA-157579 6.705576e-01 0.174 0 0
Post-translational protein phosphorylation R-HSA-8957275 6.739387e-01 0.171 0 0
Signaling by FGFR R-HSA-190236 6.739387e-01 0.171 0 0
Keratinization R-HSA-6805567 6.748781e-01 0.171 0 0
Glycolysis R-HSA-70171 6.805977e-01 0.167 0 0
Selenocysteine synthesis R-HSA-2408557 6.838763e-01 0.165 0 0
Membrane Trafficking R-HSA-199991 6.856232e-01 0.164 0 0
Viral mRNA Translation R-HSA-192823 6.903336e-01 0.161 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 6.935129e-01 0.159 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 6.935129e-01 0.159 0 0
Extracellular matrix organization R-HSA-1474244 6.997572e-01 0.155 0 0
Drug ADME R-HSA-9748784 7.021627e-01 0.154 0 0
Platelet homeostasis R-HSA-418346 7.028574e-01 0.153 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 7.059089e-01 0.151 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 7.089292e-01 0.149 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 7.089292e-01 0.149 0 0
Bile acid and bile salt metabolism R-HSA-194068 7.148777e-01 0.146 0 0
FCERI mediated MAPK activation R-HSA-2871796 7.207053e-01 0.142 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 7.264146e-01 0.139 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 7.292255e-01 0.137 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 7.320078e-01 0.135 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 7.347616e-01 0.134 0 0
Chromatin modifying enzymes R-HSA-3247509 7.355736e-01 0.133 0 0
Eukaryotic Translation Initiation R-HSA-72613 7.374873e-01 0.132 0 0
Cap-dependent Translation Initiation R-HSA-72737 7.374873e-01 0.132 0 0
Glucose metabolism R-HSA-70326 7.401852e-01 0.131 0 0
Homology Directed Repair R-HSA-5693538 7.428555e-01 0.129 0 0
Mitotic Prophase R-HSA-68875 7.481145e-01 0.126 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 7.558033e-01 0.122 0 0
Chromatin organization R-HSA-4839726 7.639643e-01 0.117 0 0
Sensory perception of taste R-HSA-9717189 7.797866e-01 0.108 0 0
Degradation of the extracellular matrix R-HSA-1474228 7.820522e-01 0.107 0 0
SLC-mediated transmembrane transport R-HSA-425407 8.042967e-01 0.095 0 0
Late Phase of HIV Life Cycle R-HSA-162599 8.074973e-01 0.093 0 0
Clathrin-mediated endocytosis R-HSA-8856828 8.094794e-01 0.092 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 8.190896e-01 0.087 0 0
Protein localization R-HSA-9609507 8.282177e-01 0.082 0 0
DNA Double-Strand Break Repair R-HSA-5693532 8.282177e-01 0.082 0 0
PPARA activates gene expression R-HSA-1989781 8.317395e-01 0.080 0 0
Asparagine N-linked glycosylation R-HSA-446203 8.346628e-01 0.078 0 0
HIV Life Cycle R-HSA-162587 8.351895e-01 0.078 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.351895e-01 0.078 0 0
Cellular response to starvation R-HSA-9711097 8.368880e-01 0.077 0 0
Signaling by WNT R-HSA-195721 8.390742e-01 0.076 0 0
Translation R-HSA-72766 8.424104e-01 0.074 0 0
Selenoamino acid metabolism R-HSA-2408522 8.467199e-01 0.072 0 0
Vesicle-mediated transport R-HSA-5653656 8.568785e-01 0.067 0 0
Toll-like Receptor Cascades R-HSA-168898 8.853564e-01 0.053 0 0
Glycosaminoglycan metabolism R-HSA-1630316 8.877124e-01 0.052 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 8.987899e-01 0.046 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.235654e-01 0.035 0 0
Metabolism of nucleotides R-HSA-15869 9.289370e-01 0.032 0 0
Phase II - Conjugation of compounds R-HSA-156580 9.311226e-01 0.031 0 0
Diseases of metabolism R-HSA-5668914 9.455911e-01 0.024 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.573540e-01 0.019 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.612092e-01 0.017 0 0
Phospholipid metabolism R-HSA-1483257 9.615980e-01 0.017 0 0
Epigenetic regulation of gene expression R-HSA-212165 9.713480e-01 0.013 0 0
Metabolism of steroids R-HSA-8957322 9.716465e-01 0.012 0 0
Transport of small molecules R-HSA-382551 9.784954e-01 0.009 0 0
DNA Repair R-HSA-73894 9.805588e-01 0.009 0 0
Post-translational protein modification R-HSA-597592 9.816995e-01 0.008 0 0
Biological oxidations R-HSA-211859 9.965537e-01 0.001 0 0
Metabolism of proteins R-HSA-392499 9.981886e-01 0.001 0 0
Metabolism of lipids R-HSA-556833 9.999855e-01 0.000 0 0
Sensory Perception R-HSA-9709957 9.999985e-01 0.000 0 0
Metabolism R-HSA-1430728 9.999995e-01 0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
G2/M DNA damage checkpoint R-HSA-69473 1.110223e-16 15.955 1 0
G2/M Checkpoints R-HSA-69481 1.110223e-16 15.955 1 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 3.885781e-15 14.411 0 0
Packaging Of Telomere Ends R-HSA-171306 1.187939e-14 13.925 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 1.187939e-14 13.925 0 0
DNA methylation R-HSA-5334118 2.364775e-14 13.626 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.331468e-14 13.632 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.331468e-14 13.632 0 0
Cell Cycle Checkpoints R-HSA-69620 4.751755e-14 13.323 1 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 6.161738e-14 13.210 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 8.326673e-14 13.080 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 1.486589e-13 12.828 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.486589e-13 12.828 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.620926e-13 12.790 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.990630e-13 12.701 0 0
PRC2 methylates histones and DNA R-HSA-212300 2.580158e-13 12.588 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 3.365086e-13 12.473 0 0
Cleavage of the damaged purine R-HSA-110331 3.365086e-13 12.473 0 0
Cell-Cell communication R-HSA-1500931 3.514966e-13 12.454 0 0
Depurination R-HSA-73927 4.363176e-13 12.360 0 0
Meiotic recombination R-HSA-912446 4.870548e-13 12.312 0 0
Meiotic synapsis R-HSA-1221632 7.361889e-13 12.133 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 7.204237e-13 12.142 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 7.361889e-13 12.133 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 7.204237e-13 12.142 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.181544e-13 12.037 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.181544e-13 12.037 0 0
Diseases of programmed cell death R-HSA-9645723 1.131428e-12 11.946 0 0
Adherens junctions interactions R-HSA-418990 1.335043e-12 11.875 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 1.468381e-12 11.833 0 0
Depyrimidination R-HSA-73928 1.468381e-12 11.833 0 0
Cell junction organization R-HSA-446728 1.592060e-12 11.798 0 0
Defective pyroptosis R-HSA-9710421 1.843414e-12 11.734 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 2.814970e-12 11.551 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 2.866041e-12 11.543 0 0
Nucleosome assembly R-HSA-774815 2.866041e-12 11.543 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.814970e-12 11.551 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 4.020784e-12 11.396 0 0
Cellular responses to stimuli R-HSA-8953897 3.970824e-12 11.401 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 4.020784e-12 11.396 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 5.382916e-12 11.269 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 6.051049e-12 11.218 0 0
Meiosis R-HSA-1500620 9.289125e-12 11.032 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.182920e-11 10.927 0 0
Cell-cell junction organization R-HSA-421270 1.464517e-11 10.834 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.513545e-11 10.820 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.768108e-11 10.752 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 1.718037e-11 10.765 0 0
HDACs deacetylate histones R-HSA-3214815 2.060685e-11 10.686 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 3.493328e-11 10.457 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 4.141942e-11 10.383 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 4.524614e-11 10.344 1 1
Processing of DNA double-strand break ends R-HSA-5693607 7.522127e-11 10.124 0 0
Cellular responses to stress R-HSA-2262752 1.006326e-10 9.997 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.079821e-10 9.967 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.079821e-10 9.967 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.159097e-10 9.936 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.271321e-10 9.896 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.338261e-10 9.873 0 0
DNA Double Strand Break Response R-HSA-5693606 1.478446e-10 9.830 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.715651e-10 9.766 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 2.296109e-10 9.639 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 2.648366e-10 9.577 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 3.048798e-10 9.516 0 0
Attenuation phase R-HSA-3371568 3.511220e-10 9.455 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 5.257556e-10 9.279 0 0
Cell Cycle R-HSA-1640170 6.167372e-10 9.210 1 0
RNA Polymerase I Transcription R-HSA-73864 6.832913e-10 9.165 0 0
Telomere Maintenance R-HSA-157579 7.673909e-10 9.115 0 0
HATs acetylate histones R-HSA-3214847 9.545436e-10 9.020 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 8.822849e-10 9.054 0 0
Amyloid fiber formation R-HSA-977225 1.000214e-09 9.000 0 0
Cellular response to heat stress R-HSA-3371556 1.118599e-09 8.951 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.313667e-09 8.882 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.444295e-09 8.840 0 0
Gene Silencing by RNA R-HSA-211000 2.421730e-09 8.616 0 0
Reproduction R-HSA-1474165 2.995218e-09 8.524 0 0
DNA Replication Pre-Initiation R-HSA-69002 2.947192e-09 8.531 0 0
HSF1-dependent transactivation R-HSA-3371571 3.022886e-09 8.520 0 0
Base Excision Repair R-HSA-73884 3.243399e-09 8.489 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 3.622220e-09 8.441 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 4.030775e-09 8.395 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 4.742139e-09 8.324 0 0
Assembly of the pre-replicative complex R-HSA-68867 5.009705e-09 8.300 0 0
Estrogen-dependent gene expression R-HSA-9018519 5.373972e-09 8.270 0 0
Interleukin-12 signaling R-HSA-9020591 6.805245e-09 8.167 0 0
Homology Directed Repair R-HSA-5693538 8.169009e-09 8.088 0 0
Mitotic Prophase R-HSA-68875 9.733173e-09 8.012 0 0
Chromosome Maintenance R-HSA-73886 1.061263e-08 7.974 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.376193e-08 7.861 0 0
ESR-mediated signaling R-HSA-8939211 1.408437e-08 7.851 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.618485e-08 7.791 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.618485e-08 7.791 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.618485e-08 7.791 0 0
Activation of HOX genes during differentiation R-HSA-5619507 1.828214e-08 7.738 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 1.828214e-08 7.738 0 0
Cellular Senescence R-HSA-2559583 1.928025e-08 7.715 0 0
DNA Replication R-HSA-69306 2.124079e-08 7.673 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 2.207080e-08 7.656 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.340742e-08 7.631 0 0
Interleukin-12 family signaling R-HSA-447115 2.618409e-08 7.582 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 4.091039e-08 7.388 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 5.138609e-08 7.289 0 0
Signaling by Interleukins R-HSA-449147 5.151538e-08 7.288 0 0
HSF1 activation R-HSA-3371511 5.850141e-08 7.233 0 0
Viral Infection Pathways R-HSA-9824446 6.194668e-08 7.208 0 0
M Phase R-HSA-68886 7.897743e-08 7.102 0 0
Signaling by NOTCH R-HSA-157118 1.008255e-07 6.996 0 0
Cell Cycle, Mitotic R-HSA-69278 1.328817e-07 6.877 1 0
DNA Double-Strand Break Repair R-HSA-5693532 1.591335e-07 6.798 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.699319e-07 6.770 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.939948e-07 6.712 0 0
Activation of BH3-only proteins R-HSA-114452 2.988341e-07 6.525 0 0
HCMV Early Events R-HSA-9609690 3.351934e-07 6.475 0 0
Co-inhibition by PD-1 R-HSA-389948 4.166129e-07 6.380 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 5.471601e-07 6.262 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 6.388911e-07 6.195 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 7.098214e-07 6.149 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 7.799453e-07 6.108 0 0
Signaling by Nuclear Receptors R-HSA-9006931 7.912420e-07 6.102 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 8.284486e-07 6.082 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.191866e-06 5.924 0 0
Regulation of CDH1 Function R-HSA-9764561 1.281309e-06 5.892 0 0
Developmental Biology R-HSA-1266738 1.395935e-06 5.855 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.708311e-06 5.767 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 1.980705e-06 5.703 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 2.446334e-06 5.611 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 2.446334e-06 5.611 0 0
Infectious disease R-HSA-5663205 3.051437e-06 5.515 0 0
AURKA Activation by TPX2 R-HSA-8854518 3.306425e-06 5.481 0 0
Ub-specific processing proteases R-HSA-5689880 3.579242e-06 5.446 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 4.384626e-06 5.358 0 0
HCMV Infection R-HSA-9609646 4.652623e-06 5.332 0 0
Immune System R-HSA-168256 5.096057e-06 5.293 0 0
Gluconeogenesis R-HSA-70263 5.409554e-06 5.267 0 0
Deubiquitination R-HSA-5688426 5.717637e-06 5.243 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 6.002352e-06 5.222 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 6.356174e-06 5.197 0 0
Signaling by WNT R-HSA-195721 6.511287e-06 5.186 0 0
Centrosome maturation R-HSA-380287 7.573878e-06 5.121 0 0
Protein ubiquitination R-HSA-8852135 7.573878e-06 5.121 0 0
Glycolysis R-HSA-70171 8.064521e-06 5.093 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 8.405842e-06 5.075 0 0
HCMV Late Events R-HSA-9610379 8.706815e-06 5.060 0 0
SARS-CoV-2-host interactions R-HSA-9705683 9.151472e-06 5.039 0 0
Apoptosis R-HSA-109581 1.128576e-05 4.947 0 0
Chromatin modifying enzymes R-HSA-3247509 1.175012e-05 4.930 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.273430e-05 4.895 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.578397e-05 4.802 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 1.705175e-05 4.768 0 0
Programmed Cell Death R-HSA-5357801 1.719314e-05 4.765 0 0
Chromatin organization R-HSA-4839726 2.127930e-05 4.672 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.293808e-05 4.639 0 0
Semaphorin interactions R-HSA-373755 2.458600e-05 4.609 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.647619e-05 4.577 0 0
Glucose metabolism R-HSA-70326 2.933134e-05 4.533 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 3.223398e-05 4.492 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 3.769461e-05 4.424 0 0
Epigenetic regulation of gene expression R-HSA-212165 6.323479e-05 4.199 0 0
Signal Transduction R-HSA-162582 7.128216e-05 4.147 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 8.385977e-05 4.076 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.148890e-04 3.940 0 0
SARS-CoV-2 Infection R-HSA-9694516 1.351079e-04 3.869 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 1.551699e-04 3.809 0 0
G2/M Transition R-HSA-69275 1.786234e-04 3.748 1 0
DNA Repair R-HSA-73894 1.823240e-04 3.739 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.929322e-04 3.715 1 0
FOXO-mediated transcription R-HSA-9614085 3.596635e-04 3.444 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 5.370168e-04 3.270 0 0
Disease R-HSA-1643685 5.705173e-04 3.244 0 0
Developmental Cell Lineages R-HSA-9734767 5.806713e-04 3.236 0 0
Manipulation of host energy metabolism R-HSA-9636667 6.024845e-04 3.220 0 0
PECAM1 interactions R-HSA-210990 6.449091e-04 3.191 0 0
PKR-mediated signaling R-HSA-9833482 6.644395e-04 3.178 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 6.717560e-04 3.173 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 9.462599e-04 3.024 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 9.462599e-04 3.024 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 9.117144e-04 3.040 0 0
Cilium Assembly R-HSA-5617833 9.037171e-04 3.044 0 0
Organelle biogenesis and maintenance R-HSA-1852241 7.633827e-04 3.117 0 0
Generic Transcription Pathway R-HSA-212436 7.601537e-04 3.119 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 9.652550e-04 3.015 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 1.023741e-03 2.990 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.030154e-03 2.987 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.068964e-03 2.971 0 0
Metabolism of RNA R-HSA-8953854 1.204604e-03 2.919 0 0
SARS-CoV Infections R-HSA-9679506 1.368430e-03 2.864 0 0
EPH-Ephrin signaling R-HSA-2682334 1.408933e-03 2.851 0 0
Signaling by VEGF R-HSA-194138 1.452692e-03 2.838 0 0
mRNA Splicing R-HSA-72172 1.453342e-03 2.838 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 1.488570e-03 2.827 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.544297e-03 2.811 0 0
RNA Polymerase II Transcription R-HSA-73857 1.648266e-03 2.783 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.921533e-03 2.716 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 2.049674e-03 2.688 0 0
MTF1 activates gene expression R-HSA-5660489 2.354838e-03 2.628 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 2.569824e-03 2.590 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.647131e-03 2.577 0 0
Signaling by RAF1 mutants R-HSA-9656223 2.824815e-03 2.549 0 0
MAP2K and MAPK activation R-HSA-5674135 2.824815e-03 2.549 0 0
Axon guidance R-HSA-422475 2.995834e-03 2.523 0 0
Extracellular matrix organization R-HSA-1474244 3.138718e-03 2.503 0 0
NTRK2 activates RAC1 R-HSA-9032759 3.180627e-03 2.497 0 0
Signal transduction by L1 R-HSA-445144 3.341838e-03 2.476 0 0
EPHB-mediated forward signaling R-HSA-3928662 3.487050e-03 2.458 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 3.487050e-03 2.458 0 0
Mitotic Prometaphase R-HSA-68877 3.845938e-03 2.415 0 0
Signaling downstream of RAS mutants R-HSA-9649948 3.982783e-03 2.400 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 3.982783e-03 2.400 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 3.982783e-03 2.400 0 0
Signaling by RAS mutants R-HSA-6802949 3.982783e-03 2.400 0 0
Apoptotic execution phase R-HSA-75153 3.982783e-03 2.400 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 4.247643e-03 2.372 0 0
L1CAM interactions R-HSA-373760 4.622775e-03 2.335 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 6.343217e-03 2.198 0 0
Deadenylation of mRNA R-HSA-429947 5.533498e-03 2.257 0 0
Neurodegenerative Diseases R-HSA-8863678 5.533498e-03 2.257 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 5.533498e-03 2.257 0 0
Syndecan interactions R-HSA-3000170 5.041173e-03 2.297 0 0
CHL1 interactions R-HSA-447041 6.343217e-03 2.198 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 5.177584e-03 2.286 0 0
Nervous system development R-HSA-9675108 5.326382e-03 2.274 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 6.343217e-03 2.198 0 0
Gene expression (Transcription) R-HSA-74160 5.461985e-03 2.263 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 5.192163e-03 2.285 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 6.668789e-03 2.176 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 7.179359e-03 2.144 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 7.179359e-03 2.144 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 7.179359e-03 2.144 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 7.573414e-03 2.121 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 7.616677e-03 2.118 0 0
Formation of annular gap junctions R-HSA-196025 7.616677e-03 2.118 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 8.231918e-03 2.084 0 0
Gap junction degradation R-HSA-190873 8.995316e-03 2.046 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 8.995316e-03 2.046 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 8.995316e-03 2.046 0 0
Interleukin-37 signaling R-HSA-9008059 9.086120e-03 2.042 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 9.327370e-03 2.030 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.739998e-03 2.011 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.047653e-02 1.980 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 1.047653e-02 1.980 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.047653e-02 1.980 0 0
G0 and Early G1 R-HSA-1538133 1.050632e-02 1.979 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.121487e-02 1.950 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 1.142449e-02 1.942 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 1.373652e-02 1.862 0 0
Adaptive Immune System R-HSA-1280218 1.435327e-02 1.843 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.459202e-02 1.836 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.519504e-02 1.818 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.737673e-02 1.760 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.737673e-02 1.760 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 1.737673e-02 1.760 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 1.737673e-02 1.760 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.741710e-02 1.759 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 1.741710e-02 1.759 0 0
CRMPs in Sema3A signaling R-HSA-399956 1.933340e-02 1.714 0 0
Regulation of KIT signaling R-HSA-1433559 1.933340e-02 1.714 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.945802e-02 1.711 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 1.945802e-02 1.711 0 0
Protein methylation R-HSA-8876725 2.137797e-02 1.670 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 2.162551e-02 1.665 0 0
Interferon Signaling R-HSA-913531 2.184536e-02 1.661 0 0
Inhibition of PKR R-HSA-169131 2.320194e-02 1.634 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 2.350815e-02 1.629 0 0
Platelet activation, signaling and aggregation R-HSA-76002 2.369527e-02 1.625 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.471967e-02 1.607 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.572169e-02 1.590 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 2.572169e-02 1.590 0 0
Response to metal ions R-HSA-5660526 2.572169e-02 1.590 0 0
Neutrophil degranulation R-HSA-6798695 2.650984e-02 1.577 0 0
Platelet degranulation R-HSA-114608 2.691609e-02 1.570 0 0
Membrane Trafficking R-HSA-199991 2.711701e-02 1.567 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.801637e-02 1.553 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.801637e-02 1.553 0 0
Signaling by Hippo R-HSA-2028269 2.801637e-02 1.553 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 3.460131e-02 1.461 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 3.460131e-02 1.461 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 3.039003e-02 1.517 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 3.796366e-02 1.421 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 3.796366e-02 1.421 0 0
FGFR2 alternative splicing R-HSA-6803529 4.336949e-02 1.363 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 4.336949e-02 1.363 0 0
Translation initiation complex formation R-HSA-72649 3.728275e-02 1.428 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 4.032899e-02 1.394 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 3.460131e-02 1.461 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 3.460131e-02 1.461 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 3.284052e-02 1.484 0 0
mTORC1-mediated signalling R-HSA-166208 4.336949e-02 1.363 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 3.413445e-02 1.467 0 0
Smooth Muscle Contraction R-HSA-445355 3.580582e-02 1.446 0 0
Rap1 signalling R-HSA-392517 3.284052e-02 1.484 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 3.612013e-02 1.442 0 0
MAPK family signaling cascades R-HSA-5683057 3.032294e-02 1.518 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 3.211235e-02 1.493 0 0
Basigin interactions R-HSA-210991 3.796366e-02 1.421 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 4.147053e-02 1.382 0 0
Vesicle-mediated transport R-HSA-5653656 3.586882e-02 1.445 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 3.796366e-02 1.421 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 4.063224e-02 1.391 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 4.063224e-02 1.391 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 4.349735e-02 1.362 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 4.396170e-02 1.357 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 4.512692e-02 1.346 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 4.586834e-02 1.338 0 0
BDNF activates NTRK2 (TRKB) signaling R-HSA-9024909 4.586834e-02 1.338 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 4.586834e-02 1.338 0 0
NTF4 activates NTRK2 (TRKB) signaling R-HSA-9026357 4.586834e-02 1.338 0 0
NTF3 activates NTRK2 (TRKB) signaling R-HSA-9025046 4.586834e-02 1.338 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 4.586834e-02 1.338 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 4.586834e-02 1.338 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 4.586834e-02 1.338 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 4.586834e-02 1.338 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 4.586834e-02 1.338 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 4.586834e-02 1.338 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 4.586834e-02 1.338 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 4.586834e-02 1.338 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 4.586834e-02 1.338 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 4.586834e-02 1.338 0 0
Diseases of Cellular Senescence R-HSA-9630747 4.586834e-02 1.338 0 0
Diseases of cellular response to stress R-HSA-9675132 4.586834e-02 1.338 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 4.617348e-02 1.336 0 0
Signaling by ERBB2 R-HSA-1227986 4.678650e-02 1.330 0 0
RSV-host interactions R-HSA-9833110 4.883867e-02 1.311 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 4.904228e-02 1.309 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 5.194341e-02 1.284 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 5.400256e-02 1.268 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 5.400256e-02 1.268 0 0
Signaling by EGFR in Cancer R-HSA-1643713 5.496688e-02 1.260 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 5.561240e-02 1.255 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 5.700456e-02 1.244 0 0
MET interacts with TNS proteins R-HSA-8875513 5.700456e-02 1.244 0 0
Interaction between L1 and Ankyrins R-HSA-445095 5.801902e-02 1.236 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 6.429411e-02 1.192 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 6.751361e-02 1.171 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 6.751361e-02 1.171 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 6.751361e-02 1.171 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 6.801148e-02 1.167 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 6.801148e-02 1.167 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 6.801148e-02 1.167 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 6.801148e-02 1.167 0 0
NADE modulates death signalling R-HSA-205025 6.801148e-02 1.167 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 6.801148e-02 1.167 0 0
Eukaryotic Translation Initiation R-HSA-72613 6.815224e-02 1.167 0 0
Cap-dependent Translation Initiation R-HSA-72737 6.815224e-02 1.167 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 7.078550e-02 1.150 0 0
Molecules associated with elastic fibres R-HSA-2129379 7.078550e-02 1.150 0 0
Signaling by NOTCH4 R-HSA-9013694 7.305263e-02 1.136 0 0
RAF/MAP kinase cascade R-HSA-5673001 7.356578e-02 1.133 0 0
Diseases of mitotic cell cycle R-HSA-9675126 7.410813e-02 1.130 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 7.410813e-02 1.130 0 0
ISG15 antiviral mechanism R-HSA-1169408 7.513568e-02 1.124 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 7.747989e-02 1.111 1 1
IRS activation R-HSA-74713 7.889060e-02 1.103 0 0
G2 Phase R-HSA-68911 7.889060e-02 1.103 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 7.889060e-02 1.103 0 0
Reelin signalling pathway R-HSA-8866376 7.889060e-02 1.103 0 0
Co-inhibition by BTLA R-HSA-9927353 7.889060e-02 1.103 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 7.889060e-02 1.103 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 7.908753e-02 1.102 0 0
NGF-independant TRKA activation R-HSA-187024 8.964339e-02 1.047 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 8.964339e-02 1.047 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 8.964339e-02 1.047 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 8.964339e-02 1.047 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 8.964339e-02 1.047 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 1.002713e-01 0.999 0 0
G2/M DNA replication checkpoint R-HSA-69478 1.002713e-01 0.999 1 1
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 1.002713e-01 0.999 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 1.107758e-01 0.956 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.107758e-01 0.956 0 0
Type I hemidesmosome assembly R-HSA-446107 1.211583e-01 0.917 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 1.211583e-01 0.917 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.211583e-01 0.917 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 1.211583e-01 0.917 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.211583e-01 0.917 0 0
Lipophagy R-HSA-9613354 1.314202e-01 0.881 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 1.614962e-01 0.792 0 0
Striated Muscle Contraction R-HSA-390522 8.089920e-02 1.092 0 0
Post-translational protein phosphorylation R-HSA-8957275 1.375942e-01 0.861 0 0
Regulation of CDH11 function R-HSA-9762292 1.415629e-01 0.849 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.515878e-01 0.819 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 1.211583e-01 0.917 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 1.614962e-01 0.792 0 0
Cyclin D associated events in G1 R-HSA-69231 1.251020e-01 0.903 0 0
G1 Phase R-HSA-69236 1.251020e-01 0.903 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 8.964339e-02 1.047 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.865549e-02 1.006 0 0
eNOS activation R-HSA-203615 8.436449e-02 1.074 0 0
Signaling by SCF-KIT R-HSA-1433557 1.212253e-01 0.916 0 0
Phosphorylation of Emi1 R-HSA-176417 8.964339e-02 1.047 0 0
Activation of TRKA receptors R-HSA-187015 1.107758e-01 0.956 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.415629e-01 0.849 0 0
vRNP Assembly R-HSA-192905 1.515878e-01 0.819 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 1.244630e-01 0.905 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.225814e-01 0.912 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.314202e-01 0.881 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 8.787425e-02 1.056 0 0
Chylomicron assembly R-HSA-8963888 1.515878e-01 0.819 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 1.614962e-01 0.792 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.286205e-01 0.891 1 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 1.449041e-01 0.839 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 1.449041e-01 0.839 0 0
LDL remodeling R-HSA-8964041 1.107758e-01 0.956 0 0
ARMS-mediated activation R-HSA-170984 1.314202e-01 0.881 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.415629e-01 0.849 0 0
Signaling by NTRKs R-HSA-166520 1.327147e-01 0.877 0 0
GPVI-mediated activation cascade R-HSA-114604 9.142698e-02 1.039 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.017870e-01 0.992 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 1.002713e-01 0.999 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 1.314202e-01 0.881 0 0
WNT mediated activation of DVL R-HSA-201688 1.314202e-01 0.881 0 0
MAPK3 (ERK1) activation R-HSA-110056 1.415629e-01 0.849 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 1.614962e-01 0.792 0 0
Autophagy R-HSA-9612973 1.496131e-01 0.825 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.539405e-01 0.813 0 0
Recycling pathway of L1 R-HSA-437239 1.369042e-01 0.864 0 0
Selective autophagy R-HSA-9663891 1.069121e-01 0.971 0 0
Oncogene Induced Senescence R-HSA-2559585 8.787425e-02 1.056 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 8.964339e-02 1.047 0 0
VLDL assembly R-HSA-8866423 1.002713e-01 0.999 0 0
Nef and signal transduction R-HSA-164944 1.002713e-01 0.999 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 1.314202e-01 0.881 0 0
Gap junction trafficking R-HSA-190828 1.251020e-01 0.903 0 0
Degradation of CDH1 R-HSA-9766229 1.449041e-01 0.839 0 0
Mitochondrial protein degradation R-HSA-9837999 1.244630e-01 0.905 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.258558e-02 1.033 0 0
Regulation of pyruvate metabolism R-HSA-9861718 1.329426e-01 0.876 0 0
Elastic fibre formation R-HSA-1566948 9.865549e-02 1.006 0 0
Regulation of TP53 Activity R-HSA-5633007 1.583590e-01 0.800 0 0
MTOR signalling R-HSA-165159 1.173794e-01 0.930 0 0
Muscle contraction R-HSA-397014 1.391286e-01 0.857 0 0
Gap junction trafficking and regulation R-HSA-157858 1.449041e-01 0.839 0 0
Pyruvate metabolism R-HSA-70268 1.044898e-01 0.981 0 0
Cell surface interactions at the vascular wall R-HSA-202733 8.395053e-02 1.076 0 0
Hemostasis R-HSA-109582 9.318669e-02 1.031 1 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.314202e-01 0.881 0 0
Signal attenuation R-HSA-74749 1.415629e-01 0.849 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.020897e-01 0.991 0 0
Metabolism of proteins R-HSA-392499 1.557362e-01 0.808 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 8.436449e-02 1.074 0 0
Interleukin-23 signaling R-HSA-9020933 1.211583e-01 0.917 0 0
Potential therapeutics for SARS R-HSA-9679191 1.368622e-01 0.864 0 0
G1/S-Specific Transcription R-HSA-69205 9.142698e-02 1.039 0 0
Response of Mtb to phagocytosis R-HSA-9637690 1.212253e-01 0.916 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 1.570790e-01 0.804 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.408917e-01 0.851 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 1.212253e-01 0.916 0 0
Interleukin-1 family signaling R-HSA-446652 1.410619e-01 0.851 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 1.570790e-01 0.804 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 1.712895e-01 0.766 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 1.712895e-01 0.766 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 1.712895e-01 0.766 0 0
Scavenging by Class F Receptors R-HSA-3000484 1.712895e-01 0.766 0 0
GRB2 events in EGFR signaling R-HSA-179812 1.712895e-01 0.766 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 1.712895e-01 0.766 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.712895e-01 0.766 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 1.712895e-01 0.766 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 1.712895e-01 0.766 0 0
Regulation of IFNG signaling R-HSA-877312 1.712895e-01 0.766 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.735947e-01 0.760 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 1.735947e-01 0.760 0 0
Dectin-2 family R-HSA-5621480 1.777674e-01 0.750 0 0
CD28 dependent Vav1 pathway R-HSA-389359 1.809691e-01 0.742 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.809691e-01 0.742 0 0
Frs2-mediated activation R-HSA-170968 1.809691e-01 0.742 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 1.809691e-01 0.742 0 0
Post-translational protein modification R-HSA-597592 1.822615e-01 0.739 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.833357e-01 0.737 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.853515e-01 0.732 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 1.882879e-01 0.725 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 1.905361e-01 0.720 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.905361e-01 0.720 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.905361e-01 0.720 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 1.905361e-01 0.720 0 0
Signal regulatory protein family interactions R-HSA-391160 1.905361e-01 0.720 0 0
Interferon alpha/beta signaling R-HSA-909733 1.941966e-01 0.712 0 0
Mitochondrial protein import R-HSA-1268020 1.988460e-01 0.701 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 1.988460e-01 0.701 0 0
SHC1 events in EGFR signaling R-HSA-180336 1.999920e-01 0.699 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 1.999920e-01 0.699 0 0
DCC mediated attractive signaling R-HSA-418885 1.999920e-01 0.699 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.999920e-01 0.699 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 1.999920e-01 0.699 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 1.999920e-01 0.699 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.999920e-01 0.699 0 0
Other semaphorin interactions R-HSA-416700 1.999920e-01 0.699 0 0
Mitochondrial biogenesis R-HSA-1592230 2.001511e-01 0.699 0 0
Signaling by PTK6 R-HSA-8848021 2.030986e-01 0.692 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 2.030986e-01 0.692 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.031447e-01 0.692 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 2.093380e-01 0.679 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 2.093380e-01 0.679 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 2.093380e-01 0.679 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 2.093380e-01 0.679 0 0
Phosphorylation of the APC/C R-HSA-176412 2.093380e-01 0.679 0 0
Prolonged ERK activation events R-HSA-169893 2.093380e-01 0.679 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 2.093380e-01 0.679 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 2.093380e-01 0.679 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 2.185754e-01 0.660 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 2.185754e-01 0.660 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 2.185754e-01 0.660 0 0
Fibronectin matrix formation R-HSA-1566977 2.185754e-01 0.660 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 2.185754e-01 0.660 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 2.185754e-01 0.660 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 2.185754e-01 0.660 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.245002e-01 0.649 0 0
Regulated Necrosis R-HSA-5218859 2.245002e-01 0.649 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 2.266924e-01 0.645 0 0
G1/S Transition R-HSA-69206 2.274465e-01 0.643 1 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.277055e-01 0.643 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 2.277055e-01 0.643 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 2.277055e-01 0.643 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 2.277055e-01 0.643 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 2.367015e-01 0.626 0 0
Ephrin signaling R-HSA-3928664 2.367294e-01 0.626 0 0
GAB1 signalosome R-HSA-180292 2.367294e-01 0.626 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.367294e-01 0.626 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.367294e-01 0.626 0 0
Platelet sensitization by LDL R-HSA-432142 2.367294e-01 0.626 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 2.367294e-01 0.626 0 0
Regulation of mitotic cell cycle R-HSA-453276 2.374243e-01 0.624 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 2.374243e-01 0.624 0 0
ECM proteoglycans R-HSA-3000178 2.374243e-01 0.624 0 0
Retinoid metabolism and transport R-HSA-975634 2.374243e-01 0.624 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 2.417418e-01 0.617 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 2.456484e-01 0.610 0 0
Regulation of signaling by CBL R-HSA-912631 2.456484e-01 0.610 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 2.456484e-01 0.610 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 2.456484e-01 0.610 0 0
STING mediated induction of host immune responses R-HSA-1834941 2.456484e-01 0.610 0 0
E2F mediated regulation of DNA replication R-HSA-113510 2.456484e-01 0.610 0 0
The NLRP3 inflammasome R-HSA-844456 2.456484e-01 0.610 0 0
Circadian clock R-HSA-9909396 2.522670e-01 0.598 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.544638e-01 0.594 0 0
Nephrin family interactions R-HSA-373753 2.544638e-01 0.594 0 0
Co-inhibition by CTLA4 R-HSA-389513 2.544638e-01 0.594 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 2.544638e-01 0.594 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.544638e-01 0.594 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 2.631767e-01 0.580 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 2.631767e-01 0.580 0 0
Integrin cell surface interactions R-HSA-216083 2.676991e-01 0.572 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 2.717883e-01 0.566 0 0
Attachment and Entry R-HSA-9694614 2.717883e-01 0.566 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 2.717883e-01 0.566 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.717883e-01 0.566 0 0
Ribavirin ADME R-HSA-9755088 2.717883e-01 0.566 0 0
Sensory processing of sound R-HSA-9659379 2.720282e-01 0.565 0 0
Signaling by FGFR2 R-HSA-5654738 2.763564e-01 0.559 0 0
Parasitic Infection Pathways R-HSA-9824443 2.799198e-01 0.553 0 0
Leishmania infection R-HSA-9658195 2.799198e-01 0.553 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 2.802997e-01 0.552 0 0
Signaling by KIT in disease R-HSA-9669938 2.802997e-01 0.552 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 2.802997e-01 0.552 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 2.802997e-01 0.552 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 2.802997e-01 0.552 0 0
Leishmania phagocytosis R-HSA-9664417 2.806283e-01 0.552 0 0
Parasite infection R-HSA-9664407 2.806283e-01 0.552 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 2.806283e-01 0.552 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 2.806834e-01 0.552 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 2.806834e-01 0.552 0 0
Macroautophagy R-HSA-1632852 2.838001e-01 0.547 0 0
Termination of O-glycan biosynthesis R-HSA-977068 2.887122e-01 0.540 0 0
Interleukin receptor SHC signaling R-HSA-912526 2.887122e-01 0.540 0 0
Formation of the ureteric bud R-HSA-9830674 2.887122e-01 0.540 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.887122e-01 0.540 0 0
Growth hormone receptor signaling R-HSA-982772 2.887122e-01 0.540 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 2.887122e-01 0.540 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 2.970269e-01 0.527 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 2.970269e-01 0.527 0 0
Plasma lipoprotein assembly R-HSA-8963898 2.970269e-01 0.527 0 0
Mitochondrial RNA degradation R-HSA-9836573 2.970269e-01 0.527 0 0
Complex III assembly R-HSA-9865881 2.970269e-01 0.527 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 2.970269e-01 0.527 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 2.979666e-01 0.526 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 3.022787e-01 0.520 0 0
Laminin interactions R-HSA-3000157 3.052449e-01 0.515 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 3.052449e-01 0.515 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 3.052449e-01 0.515 0 0
HDMs demethylate histones R-HSA-3214842 3.052449e-01 0.515 0 0
Sema4D in semaphorin signaling R-HSA-400685 3.052449e-01 0.515 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 3.052449e-01 0.515 0 0
Chaperonin-mediated protein folding R-HSA-390466 3.108890e-01 0.507 0 0
MET activates PTK2 signaling R-HSA-8874081 3.133674e-01 0.504 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 3.133674e-01 0.504 0 0
MITF-M-dependent gene expression R-HSA-9856651 3.156503e-01 0.501 0 0
Cristae formation R-HSA-8949613 3.213953e-01 0.493 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 3.213953e-01 0.493 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 3.213953e-01 0.493 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 3.213953e-01 0.493 0 0
Insulin processing R-HSA-264876 3.213953e-01 0.493 0 0
Innate Immune System R-HSA-168249 3.214106e-01 0.493 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 3.293299e-01 0.482 0 0
Insulin receptor recycling R-HSA-77387 3.293299e-01 0.482 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 3.293299e-01 0.482 0 0
Telomere Extension By Telomerase R-HSA-171319 3.293299e-01 0.482 0 0
Inflammasomes R-HSA-622312 3.293299e-01 0.482 0 0
Pyroptosis R-HSA-5620971 3.293299e-01 0.482 0 0
Eukaryotic Translation Elongation R-HSA-156842 3.365748e-01 0.473 0 0
Protein folding R-HSA-391251 3.365748e-01 0.473 0 0
Late endosomal microautophagy R-HSA-9615710 3.371722e-01 0.472 0 0
Thyroxine biosynthesis R-HSA-209968 3.371722e-01 0.472 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.371722e-01 0.472 0 0
DARPP-32 events R-HSA-180024 3.371722e-01 0.472 0 0
FCGR activation R-HSA-2029481 3.408302e-01 0.467 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 3.408302e-01 0.467 0 0
rRNA processing R-HSA-72312 3.432146e-01 0.464 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 3.449233e-01 0.462 0 0
DAP12 signaling R-HSA-2424491 3.449233e-01 0.462 0 0
Activation of the pre-replicative complex R-HSA-68962 3.449233e-01 0.462 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 3.449233e-01 0.462 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 3.449233e-01 0.462 0 0
Collagen formation R-HSA-1474290 3.450771e-01 0.462 0 0
EGFR downregulation R-HSA-182971 3.525842e-01 0.453 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 3.525842e-01 0.453 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 3.525842e-01 0.453 0 0
HS-GAG degradation R-HSA-2024096 3.601560e-01 0.444 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 3.619731e-01 0.441 0 0
Signaling by FGFR R-HSA-190236 3.661724e-01 0.436 0 0
Integrin signaling R-HSA-354192 3.676397e-01 0.435 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 3.676397e-01 0.435 0 0
Activation of ATR in response to replication stress R-HSA-176187 3.676397e-01 0.435 0 0
Regulation of necroptotic cell death R-HSA-5675482 3.676397e-01 0.435 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 3.750364e-01 0.426 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 3.750364e-01 0.426 0 0
RAF activation R-HSA-5673000 3.823469e-01 0.418 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 3.823469e-01 0.418 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 3.823469e-01 0.418 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 3.823469e-01 0.418 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 3.823469e-01 0.418 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 3.823469e-01 0.418 0 0
Mitophagy R-HSA-5205647 3.823469e-01 0.418 0 0
RA biosynthesis pathway R-HSA-5365859 3.823469e-01 0.418 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 3.895724e-01 0.409 0 0
Signalling to ERKs R-HSA-187687 3.895724e-01 0.409 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 3.895724e-01 0.409 0 0
HS-GAG biosynthesis R-HSA-2022928 3.967138e-01 0.402 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 3.967138e-01 0.402 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 3.967138e-01 0.402 0 0
Triglyceride catabolism R-HSA-163560 3.967138e-01 0.402 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 3.982890e-01 0.400 1 1
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 3.993607e-01 0.399 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 4.037721e-01 0.394 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 4.037721e-01 0.394 0 0
Ovarian tumor domain proteases R-HSA-5689896 4.037721e-01 0.394 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 4.075342e-01 0.390 0 0
Signaling by ALK in cancer R-HSA-9700206 4.075342e-01 0.390 0 0
MET promotes cell motility R-HSA-8875878 4.107483e-01 0.386 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 4.107483e-01 0.386 0 0
Influenza Infection R-HSA-168255 4.108211e-01 0.386 0 0
Stabilization of p53 R-HSA-69541 4.176432e-01 0.379 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 4.176432e-01 0.379 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 4.176432e-01 0.379 0 0
Signaling by ALK R-HSA-201556 4.176432e-01 0.379 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 4.178835e-01 0.379 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 4.196931e-01 0.377 0 0
MyD88-independent TLR4 cascade R-HSA-166166 4.196931e-01 0.377 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 4.244579e-01 0.372 0 0
Diseases of Immune System R-HSA-5260271 4.244579e-01 0.372 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 4.244579e-01 0.372 0 0
Aggrephagy R-HSA-9646399 4.244579e-01 0.372 0 0
Interleukin-2 family signaling R-HSA-451927 4.244579e-01 0.372 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 4.311933e-01 0.365 0 0
PKMTs methylate histone lysines R-HSA-3214841 4.311933e-01 0.365 0 0
FLT3 Signaling R-HSA-9607240 4.311933e-01 0.365 0 0
Scavenging by Class A Receptors R-HSA-3000480 4.378503e-01 0.359 0 0
Negative regulation of MAPK pathway R-HSA-5675221 4.378503e-01 0.359 0 0
Toll-like Receptor Cascades R-HSA-168898 4.479025e-01 0.349 0 0
Rab regulation of trafficking R-HSA-9007101 4.553846e-01 0.342 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 4.573597e-01 0.340 0 0
DAP12 interactions R-HSA-2172127 4.573597e-01 0.340 0 0
Netrin-1 signaling R-HSA-373752 4.573597e-01 0.340 0 0
RMTs methylate histone arginines R-HSA-3214858 4.573597e-01 0.340 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 4.637120e-01 0.334 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 4.637120e-01 0.334 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 4.637120e-01 0.334 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 4.637120e-01 0.334 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 4.637120e-01 0.334 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 4.699903e-01 0.328 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 4.699903e-01 0.328 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 4.699903e-01 0.328 0 0
Regulation of TNFR1 signaling R-HSA-5357905 4.699903e-01 0.328 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 4.708427e-01 0.327 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 4.708427e-01 0.327 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 4.761955e-01 0.322 0 0
MHC class II antigen presentation R-HSA-2132295 4.784734e-01 0.320 0 0
Formation of the cornified envelope R-HSA-6809371 4.822637e-01 0.317 0 0
Co-stimulation by CD28 R-HSA-389356 4.823285e-01 0.317 0 0
GPER1 signaling R-HSA-9634597 4.823285e-01 0.317 0 0
Plasma lipoprotein remodeling R-HSA-8963899 4.823285e-01 0.317 0 0
NGF-stimulated transcription R-HSA-9031628 4.823285e-01 0.317 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 4.935326e-01 0.307 0 0
Regulation of RAS by GAPs R-HSA-5658442 4.943809e-01 0.306 0 0
Azathioprine ADME R-HSA-9748787 4.943809e-01 0.306 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 4.943809e-01 0.306 0 0
Hedgehog ligand biogenesis R-HSA-5358346 5.003020e-01 0.301 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 5.061541e-01 0.296 0 0
mRNA 3'-end processing R-HSA-72187 5.061541e-01 0.296 0 0
Orc1 removal from chromatin R-HSA-68949 5.061541e-01 0.296 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 5.061541e-01 0.296 0 0
PIP3 activates AKT signaling R-HSA-1257604 5.066873e-01 0.295 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 5.119381e-01 0.291 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 5.119381e-01 0.291 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 5.176547e-01 0.286 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 5.233046e-01 0.281 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 5.233046e-01 0.281 0 0
Signaling by NOTCH3 R-HSA-9012852 5.233046e-01 0.281 0 0
Signaling by EGFR R-HSA-177929 5.288888e-01 0.277 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 5.288888e-01 0.277 0 0
Metabolism of amine-derived hormones R-HSA-209776 5.288888e-01 0.277 0 0
TNF signaling R-HSA-75893 5.288888e-01 0.277 0 0
Bacterial Infection Pathways R-HSA-9824439 5.300127e-01 0.276 0 0
Nuclear Envelope Breakdown R-HSA-2980766 5.344078e-01 0.272 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 5.398626e-01 0.268 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 5.452537e-01 0.263 0 0
Extension of Telomeres R-HSA-180786 5.452537e-01 0.263 0 0
Triglyceride metabolism R-HSA-8979227 5.452537e-01 0.263 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 5.452537e-01 0.263 0 0
Unfolded Protein Response (UPR) R-HSA-381119 5.474992e-01 0.262 0 0
Signaling by Retinoic Acid R-HSA-5362517 5.505821e-01 0.259 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 5.558483e-01 0.255 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 5.558483e-01 0.255 0 0
NCAM signaling for neurite out-growth R-HSA-375165 5.610532e-01 0.251 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 5.610532e-01 0.251 0 0
Complex I biogenesis R-HSA-6799198 5.661973e-01 0.247 0 0
IGF1R signaling cascade R-HSA-2428924 5.712815e-01 0.243 0 0
Insulin receptor signalling cascade R-HSA-74751 5.712815e-01 0.243 0 0
CD22 mediated BCR regulation R-HSA-5690714 5.712815e-01 0.243 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 5.712815e-01 0.243 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 5.763064e-01 0.239 0 0
ER to Golgi Anterograde Transport R-HSA-199977 5.779074e-01 0.238 0 0
Visual phototransduction R-HSA-2187338 5.779074e-01 0.238 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 5.811930e-01 0.236 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 5.861812e-01 0.232 0 0
Kidney development R-HSA-9830369 5.861812e-01 0.232 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 5.877080e-01 0.231 0 0
O-linked glycosylation of mucins R-HSA-913709 5.910324e-01 0.228 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 5.910324e-01 0.228 0 0
Protein localization R-HSA-9609507 5.973401e-01 0.224 0 0
Death Receptor Signaling R-HSA-73887 6.005133e-01 0.221 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 6.005657e-01 0.221 1 1
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 6.005657e-01 0.221 0 0
COPII-mediated vesicle transport R-HSA-204005 6.005657e-01 0.221 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 6.036677e-01 0.219 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 6.052491e-01 0.218 0 0
Metabolism of cofactors R-HSA-8978934 6.052491e-01 0.218 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 6.052491e-01 0.218 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 6.098779e-01 0.215 1 1
trans-Golgi Network Vesicle Budding R-HSA-199992 6.098779e-01 0.215 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 6.098779e-01 0.215 0 0
Translation R-HSA-72766 6.104580e-01 0.214 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 6.130186e-01 0.213 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 6.144527e-01 0.212 0 0
Switching of origins to a post-replicative state R-HSA-69052 6.144527e-01 0.212 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 6.144527e-01 0.212 0 0
Intracellular signaling by second messengers R-HSA-9006925 6.161587e-01 0.210 0 0
Signaling by ERBB4 R-HSA-1236394 6.189742e-01 0.208 0 0
Signaling by TGFB family members R-HSA-9006936 6.191590e-01 0.208 0 0
UCH proteinases R-HSA-5689603 6.278594e-01 0.202 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 6.408023e-01 0.193 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 6.450163e-01 0.190 0 0
Signaling by MET R-HSA-6806834 6.450163e-01 0.190 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 6.450163e-01 0.190 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 6.532974e-01 0.185 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 6.544376e-01 0.184 0 0
Leishmania parasite growth and survival R-HSA-9664433 6.600588e-01 0.180 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 6.600588e-01 0.180 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 6.613862e-01 0.180 0 0
Amplification of signal from the kinetochores R-HSA-141424 6.692873e-01 0.174 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 6.692873e-01 0.174 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 6.692873e-01 0.174 0 0
Respiratory electron transport R-HSA-611105 6.737929e-01 0.171 0 0
Post NMDA receptor activation events R-HSA-438064 6.770051e-01 0.169 0 0
Peptide chain elongation R-HSA-156902 6.807965e-01 0.167 0 0
ER-Phagosome pathway R-HSA-1236974 6.845436e-01 0.165 0 0
Neurotransmitter release cycle R-HSA-112310 6.882470e-01 0.162 0 0
Diseases of glycosylation R-HSA-3781865 6.896789e-01 0.161 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 6.919071e-01 0.160 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 6.955244e-01 0.158 0 0
Signaling by Insulin receptor R-HSA-74752 6.990996e-01 0.155 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 6.990996e-01 0.155 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 7.095763e-01 0.149 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 7.129873e-01 0.147 0 0
Eukaryotic Translation Termination R-HSA-72764 7.129873e-01 0.147 0 0
Formation of a pool of free 40S subunits R-HSA-72689 7.129873e-01 0.147 0 0
COPI-mediated anterograde transport R-HSA-6807878 7.163584e-01 0.145 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 7.163584e-01 0.145 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 7.229830e-01 0.141 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 7.229830e-01 0.141 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 7.229830e-01 0.141 0 0
Synthesis of bile acids and bile salts R-HSA-192105 7.262373e-01 0.139 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 7.262373e-01 0.139 0 0
Mitotic Spindle Checkpoint R-HSA-69618 7.294536e-01 0.137 0 0
Selenocysteine synthesis R-HSA-2408557 7.326323e-01 0.135 0 0
Interleukin-1 signaling R-HSA-9020702 7.326323e-01 0.135 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 7.335602e-01 0.135 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 7.357739e-01 0.133 0 0
PI Metabolism R-HSA-1483255 7.357739e-01 0.133 0 0
Viral mRNA Translation R-HSA-192823 7.388787e-01 0.131 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 7.419472e-01 0.130 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 7.419472e-01 0.130 0 0
Opioid Signalling R-HSA-111885 7.419472e-01 0.130 0 0
Keratinization R-HSA-6805567 7.447800e-01 0.128 0 0
Nucleotide Excision Repair R-HSA-5696398 7.479771e-01 0.126 0 0
Platelet homeostasis R-HSA-418346 7.509393e-01 0.124 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 7.538668e-01 0.123 0 0
Synthesis of DNA R-HSA-69239 7.538668e-01 0.123 0 0
Antigen processing-Cross presentation R-HSA-1236975 7.567601e-01 0.121 0 0
Stimuli-sensing channels R-HSA-2672351 7.567601e-01 0.121 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.567601e-01 0.121 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 7.596196e-01 0.119 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 7.596196e-01 0.119 0 0
Bile acid and bile salt metabolism R-HSA-194068 7.624457e-01 0.118 0 0
Mitotic Anaphase R-HSA-68882 7.660141e-01 0.116 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 7.679990e-01 0.115 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 7.679990e-01 0.115 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 7.680513e-01 0.115 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 7.707270e-01 0.113 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 7.787211e-01 0.109 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 7.813237e-01 0.107 0 0
Peptide hormone metabolism R-HSA-2980736 7.864379e-01 0.104 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 7.914331e-01 0.102 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 7.914331e-01 0.102 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 7.914331e-01 0.102 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 7.987089e-01 0.098 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 7.987089e-01 0.098 0 0
Host Interactions of HIV factors R-HSA-162909 8.034185e-01 0.095 0 0
Metabolism of nucleotides R-HSA-15869 8.039316e-01 0.095 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 8.253724e-01 0.083 0 0
Metabolism of vitamins and cofactors R-HSA-196854 8.305815e-01 0.081 0 0
O-linked glycosylation R-HSA-5173105 8.373554e-01 0.077 0 0
Ribosome-associated quality control R-HSA-9948299 8.392714e-01 0.076 0 0
Signaling by Hedgehog R-HSA-5358351 8.392714e-01 0.076 0 0
Cellular response to chemical stress R-HSA-9711123 8.533599e-01 0.069 0 0
S Phase R-HSA-69242 8.589223e-01 0.066 1 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 8.654591e-01 0.063 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 8.654591e-01 0.063 0 0
Arachidonate metabolism R-HSA-2142753 8.654591e-01 0.063 0 0
Cellular response to starvation R-HSA-9711097 8.747037e-01 0.058 0 0
Interferon gamma signaling R-HSA-877300 8.761818e-01 0.057 0 0
Separation of Sister Chromatids R-HSA-2467813 8.833161e-01 0.054 0 0
Selenoamino acid metabolism R-HSA-2408522 8.833161e-01 0.054 0 0
G alpha (s) signalling events R-HSA-418555 8.938901e-01 0.049 0 0
Transmission across Chemical Synapses R-HSA-112315 9.126125e-01 0.040 0 0
Ion channel transport R-HSA-983712 9.143245e-01 0.039 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.183045e-01 0.037 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 9.248320e-01 0.034 0 0
Signaling by ROBO receptors R-HSA-376176 9.274681e-01 0.033 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.274681e-01 0.033 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 9.356087e-01 0.029 0 0
Drug ADME R-HSA-9748784 9.400498e-01 0.027 0 0
HIV Infection R-HSA-162906 9.461465e-01 0.024 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.474153e-01 0.023 0 0
G alpha (q) signalling events R-HSA-416476 9.653700e-01 0.015 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.674316e-01 0.014 0 0
Diseases of metabolism R-HSA-5668914 9.690392e-01 0.014 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.707061e-01 0.013 0 0
Phospholipid metabolism R-HSA-1483257 9.760976e-01 0.011 0 0
Neuronal System R-HSA-112316 9.796368e-01 0.009 0 0
Metabolism of steroids R-HSA-8957322 9.831138e-01 0.007 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.917885e-01 0.004 0 0
G alpha (i) signalling events R-HSA-418594 9.938505e-01 0.003 0 0
Fatty acid metabolism R-HSA-8978868 9.938505e-01 0.003 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.958177e-01 0.002 0 0
GPCR downstream signalling R-HSA-388396 9.958972e-01 0.002 0 0
Signaling by GPCR R-HSA-372790 9.982254e-01 0.001 0 0
Biological oxidations R-HSA-211859 9.984894e-01 0.001 0 0
Sensory Perception R-HSA-9709957 9.998277e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999278e-01 0.000 0 0
Metabolism R-HSA-1430728 9.999947e-01 0.000 0 0
Metabolism of lipids R-HSA-556833 9.999982e-01 0.000 0 0
Polo-like kinase mediated events R-HSA-156711 1.000000e+00 0.000 1 1
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways