ULK3

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
A5A3E0 S1068 Sugiyama POTEF A26C1B SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
A5A3E0 S939 Sugiyama POTEF A26C1B VALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPE
A6NKT7 S1006 Sugiyama RGPD3 RGP3 FGKKDLNFKGFSGAGEKLFSsQYGKMANKANtsGDFEKDDD
A6NMY6 S26 Sugiyama ANXA2P2 ANX2L2 ANX2P2 LPC2B EILCKLsLEGDHstPPsAyGsVKAytNFDAERDALNIEtAI
O00232 S343 Sugiyama PSMD12 DYGMELRKGsLEsPAtDVFGsTEEGEKRWKDLKNRVVEHNI
O00571 S83 Sugiyama DDX3X DBX DDX3 sKDKDAyssFGsRsDsRGKssFFsDRGsGsRGRFDDRGRsD
O00625 S225 Sugiyama PIR PDDAQQKIEPHHTAVLGEGDsVQVENKDPKRSHFVLIAGEP
O15143 S323 Sugiyama ARPC1B ARC41 QNLDKKAssEGGtAAGAGLDsLHKNsVsQIsVLsGGKAKCS
O15212 S53 Sugiyama PFDN6 HKE2 PFD6 LEAQLtENNIVKEELALLDGsNVVFKLLGPVLVKQELGEAR
O15305 S230 Sugiyama PMM2 KTMPGGNDHEIFTDPRTMGysVTAPEDTRRICELLFS____
O15355 S363 Sugiyama PPM1G PPM1C VANAGDsRCVVsEAGKALDMsyDHKPEDEVELARIKNAGGK
O43175 S280 Sugiyama PHGDH PGDH3 DVFTEEPPRDRALVDHENVIsCPHLGAsTKEAQSRCGEEIA
O43175 S287 Sugiyama PHGDH PGDH3 PRDRALVDHENVIsCPHLGAsTKEAQSRCGEEIAVQFVDMV
O43290 S378 Sugiyama SART1 DGLRERELEEIRAKLRLQAQsLSTVGPRLASEYLtPEEMVT
O43399 S21 Sugiyama TPD52L2 MDsAGQDINLNsPNKGLLsDsMtDVPVDTGVAARtPAVEGL
O43852 S300 Sugiyama CALU NKDGKLTKEEIVDKyDLFVGsQAtDFGEALVRHDEF_____
O60361 S84 Sugiyama NME2P1 EGLNVVKTGRVMLGEtNPADsKPGtIRGDFCIQVGRNIIHG
O60664 S175 Sugiyama PLIN3 M6PRBP1 TIP47 RGAVQSGVDKTKsVVtGGVQsVMGsRLGQMVLsGVDtVLGK
O60664 S225 Sugiyama PLIN3 M6PRBP1 TIP47 PLTDAELARIAtsLDGFDVAsVQQQRQEQSyFVRLGsLSER
O60716 S252 Sugiyama CTNND1 KIAA0384 sRVtRIEERyRPsMEGyRAPsRQDVyGPQPQVRVGGssVDL
O60841 S214 Sugiyama EIF5B IF2 KIAA0741 LQsRKGQKKNQKNKPGPNIEsGNEDDDAsFKIKTVAQKKAE
O75116 S700 Sugiyama ROCK2 KIAA0619 EKEKSNMEIDMTYQLKVIQQsLEQEEAEHKATKARLADKNK
O75122 S1007 Sugiyama CLASP2 KIAA0627 GGDATDssQTALDNKAsLLHsMPtHssPRsRDyNPyNysDs
O75533 S308 Sugiyama SF3B1 SAP155 ARKNRWDEtPKtERDtPGHGsGWAEtPRtDRGGDsIGEtPt
O75533 S322 Sugiyama SF3B1 SAP155 DtPGHGsGWAEtPRtDRGGDsIGEtPtPGAsKRKsRWDEtP
O75533 T316 Sugiyama SF3B1 SAP155 tPKtERDtPGHGsGWAEtPRtDRGGDsIGEtPtPGAsKRKs
O75937 S81 Sugiyama DNAJC8 SPF31 HSPC315 HSPC331 VLQIDPEVTDEEIKKRFRQLsILVHPDKNQDDADRAQKAFE
O94776 S433 Sugiyama MTA2 MTA1L1 PID ATRGtTEPHSRGHLsRPEAQsLsPyttsANRAKLLAKNRQt
O95359 S2534 Sugiyama TACC2 tEELDyRNsYEIEyMEKIGssLPQDDDAPKKQALYLMFDts
O95757 S599 Sugiyama HSPA4L APG1 HSPH3 OSP94 sIDLPIQssLCRQLGQDLLNsyIENEGKMIMQDKLEKERND
P00338 T322 Sugiyama LDHA PIG19 DLVKVTLtsEEEARLKKsADtLWGIQKELQF__________
P00813 S291 Sugiyama ADA ADA1 AWKPDTEHAVIRLKNDQANysLNTDDPLIFKSTLDTDyQMT
P04075 S336 Sugiyama ALDOA ALDA GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04075 S354 Sugiyama ALDOA ALDA ANsLACQGKytPsGQAGAAAsEsLFVsNHAy__________
P04075 S356 Sugiyama ALDOA ALDA sLACQGKytPsGQAGAAAsEsLFVsNHAy____________
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04083 S189 Sugiyama ANXA1 ANX1 LPC1 tsDtsGDFRNALLsLAKGDRsEDFGVNEDLADsDARALyEA
P04406 S151 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 FVMGVNHEKYDNSLKIIsNAsCttNCLAPLAKVIHDNFGIV
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P05387 S29 Sugiyama RPLP2 D11S2243E RPP2 LAALGGNssPsAKDIKKILDsVGIEADDDRLNKVIsELNGK
P05783 S177 Sugiyama KRT18 CYK18 PIG46 ARLAADDFRVKyETELAMRQsVENDIHGLRKVIDDTNItRL
P05783 S323 Sugiyama KRT18 CYK18 PIG46 VQsLEIDLDsMRNLKAsLENsLREVEARYALQMEQLNGILL
P05787 S330 Sugiyama KRT8 CYK8 MNRNISRLQAEIEGLKGQRAsLEAAIADAEQRGELAIKDAN
P05787 S410 Sugiyama KRT8 CYK8 TYRKLLEGEESRLEsGMQNMsIHtKTTSGYAGGLSSAYGGL
P06733 S353 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 NEKsCNCLLLKVNQIGsVTEsLQACKLAQANGWGVMVsHRs
P06756 S127 Sugiyama ITGAV MSK8 VNRA VTNR NRDYAKDDPLEFKSHQWFGAsVRSKQDKILACAPLYHWRTE
P07195 S44 Sugiyama LDHB ITVVGVGQVGMACAISILGKsLADELALVDVLEDKLKGEMM
P07355 S184 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D sGDFRKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVK
P07355 S26 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D EILCKLsLEGDHstPPsAyGsVKAytNFDAERDALNIEtAI
P07437 S115 Sugiyama TUBB TUBB5 OK/SW-cl.56 sGAGNNWAKGHytEGAELVDsVLDVVRKEAESCDCLQGFQL
P07437 S75 Sugiyama TUBB TUBB5 OK/SW-cl.56 tGGKyVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
P07737 S30 Sugiyama PFN1 NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV
P07814 S1473 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 CEDWIKKtTARDQDLEPGAPsMGAKSLCIPFKPLCELQPGA
P07814 S1511 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 PGAKCVCGKNPAKyytLFGRsy___________________
P07814 S335 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 PIEKNLQMWEEMKKGsQFGQsCCLRAKIDMSSNNGCMRDPt
P07814 S882 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 AQYKEKTGKEyIPGQPPLsQssDssPtRNsEPAGLEtPEAK
P07900 S165 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA AEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGEPMGRGTK
P07900 S169 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA TVITKHNDDEQyAWEssAGGsFtVRTDTGEPMGRGTKVILH
P07900 T171 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA ITKHNDDEQyAWEssAGGsFtVRTDTGEPMGRGTKVILHLK
P08195 S253 Sugiyama SLC3A2 MDU1 FQGHGAGNLAGLKGRLDyLssLKVKGLVLGPIHKNQKDDVA
P08195 S403 Sugiyama SLC3A2 MDU1 SDLQQILSLLESNKDLLLtssyLsDsGstGEHtKSLVTQYL
P08195 S598 Sugiyama SLC3A2 MDU1 LQASDLPASASLPAKADLLLstQPGREEGsPLELERLKLEP
P08238 S160 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB AEKVVVITKHNDDEQyAWEssAGGsFtVRADHGEPIGRGTK
P08238 S164 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB VVITKHNDDEQyAWEssAGGsFtVRADHGEPIGRGTKVILH
P08238 S497 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB KEtQKsIyyItGEsKEQVANsAFVERVRKRGFEVVyMtEPI
P08238 T166 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB ITKHNDDEQyAWEssAGGsFtVRADHGEPIGRGTKVILHLK
P09382 S63 Sugiyama LGALS1 CLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVFPFQPG
P09417 S163 Sugiyama QDPR DHPR SDR33C1 GTPGMIGYGMAKGAVHQLCQsLAGKNSGMPPGAAAIAVLPV
P09874 S542 Sugiyama PARP1 ADPRT PPOL RMKLTLKGGAAVDPDsGLEHsAHVLEKGGKVFSATLGLVDI
P0CG38 S1068 Sugiyama POTEI SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39 S1031 Sugiyama POTEJ SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0DPH7 S48 Sugiyama TUBA3C TUBA2 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P10809 S453 Sugiyama HSPD1 HSP60 EEGIVLGGGCALLRCIPALDsLtPANEDQKIGIEIIKRTLK
P10809 S537 Sugiyama HSPD1 HSP60 GIIDPTKVVRTALLDAAGVAsLLTTAEVVVTEIPKEEKDPG
P10809 T428 Sugiyama HSPD1 HSP60 GtsDVEVNEKKDRVtDALNAtRAAVEEGIVLGGGCALLRCI
P11142 T64 Sugiyama HSPA8 HSC70 HSP73 HSPA10 FtDtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQ
P11142 T66 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQsD
P11279 S335 Sugiyama LAMP1 DPAFKAANGSLRALQATVGNsYKCNAEEHVRVTKAFSVNIF
P12268 S416 Sugiyama IMPDH2 IMPD2 APGEYFFSDGIRLKKyRGMGsLDAMDKHLssQNRyFsEADK
P13639 S23 Sugiyama EEF2 EF2 NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639 S38 Sugiyama EEF2 EF2 NIRNMsVIAHVDHGKStLtDsLVCKAGIIAsARAGEtRFtD
P13639 S593 Sugiyama EEF2 EF2 SDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGL
P13667 S126 Sugiyama PDIA4 ERP70 ERP72 NILKDKDPPIPVAKIDAtsAsVLAsRFDVsGyPtIKILKKG
P13667 S379 Sugiyama PDIA4 ERP70 ERP72 QPEKFQSKYEPRSHMMDVQGstQDsAIKDFVLKyALPLVGH
P13674 T140 Sugiyama P4HA1 P4HA YFPNDEDQVGAAKALLRLQDtyNLDTDtIsKGNLPGVKHKS
P13797 S110 Sugiyama PLS3 AKTFRKAINRKEGICALGGTsELssEGtQHsysEEEKyAFV
P13861 S58 Sugiyama PRKAR2A PKR2 PRKAR2 TRLREARAPAsVLPAAtPRQsLGHPPPEPGPDRVADAKGDs
P14314 S126 Sugiyama PRKCSH G19P1 yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14618 S202 Sugiyama PKM OIP3 PK2 PK3 PKM2 SLQVKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVs
P14618 S77 Sugiyama PKM OIP3 PK2 PK3 PKM2 sVEtLKEMIKsGMNVARLNFsHGtHEyHAEtIKNVRtAtEs
P14618 T87 Sugiyama PKM OIP3 PK2 PK3 PKM2 sGMNVARLNFsHGtHEyHAEtIKNVRtAtEsFAsDPILyRP
P14625 S515 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 GVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEKQ
P15259 S189 Sugiyama PGAM2 PGAMM EEIVPQIKAGKRVLIAAHGNsLRGIVKHLEGMSDQAIMELN
P15311 S535 Sugiyama EZR VIL2 EKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHN
P15374 S126 Sugiyama UCHL3 NNKDKMHFESGSTLKKFLEEsVsMsPEERARyLENyDAIRV
P15531 S122 Sugiyama NME1 NDPKA NM23 GtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDy
P15531 S99 Sugiyama NME1 NDPKA NM23 EGLNVVKTGRVMLGEtNPADsKPGtIRGDFCIQVGRNIIHG
P17844 S520 Sugiyama DDX5 G17P1 HELR HLR1 GKRGGFNTFRDRENYDRGYssLLKRDFGAKTQNGVYSAANY
P17987 S544 Sugiyama TCP1 CCT1 CCTA ILRIDDLIKLHPESKDDKHGsyEDAVHsGALND________
P18615 S113 Sugiyama NELFE RD RDBP EGKLKDPEKGPVPTFQPFQRsIsADDDLQEsSRRPQRKsLy
P18669 S155 Sugiyama PGAM1 PGAMA CDABP0006 NIsKDRRyADLtEDQLPsCEsLKDtIARALPFWNEEIVPQI
P18669 S189 Sugiyama PGAM1 PGAMA CDABP0006 EEIVPQIKEGKRVLIAAHGNsLRGIVKHLEGLSEEAIMELN
P18669 T159 Sugiyama PGAM1 PGAMA CDABP0006 DRRyADLtEDQLPsCEsLKDtIARALPFWNEEIVPQIKEGK
P19338 S458 Sugiyama NCL TEADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKN
P20674 T105 Sugiyama COX5A EPKIIDAALRACRRLNDFAstVRILEVVKDKAGPHKEIYPY
P20810 S297 Sugiyama CAST KKRKVEKDtMsDQALEALsAsLGTRQAEPELDLRsIKEVDE
P20810 S577 Sugiyama CAST PRDtsQsDKDLDDALDKLsDsLGQRQPDPDENKPMEDKVKE
P22090 S204 Sugiyama RPS4Y1 RPS4Y PRO2646 IGGANLGRVGVITNRERHPGsFDVVHVKDANGNSFATRLSN
P22392 S99 Sugiyama NME2 NM23B EGLNVVKTGRVMLGEtNPADsKPGtIRGDFCIQVGRNIIHG
P23246 S283 Sugiyama SFPQ PSF GPGGRsEEKIsDsEGFKANLsLLRRPGEKTyTQRCRLFVGN
P23284 S117 Sugiyama PPIB CYPB IKDFMIQGGDFtRGDGtGGKsIyGERFPDENFKLKHyGPGW
P23381 T383 Sugiyama WARS1 IFI53 WARS WRS DtAKQIKTKVNKHAFsGGRDtIEEHRQFGGNCDVDVSFMYL
P23588 S207 Sugiyama EIF4B DRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYRDR
P23921 S780 Sugiyama RRM1 RR1 KEKVSKEEEEKERNtAAMVCsLENRDECLMCGS________
P23921 T774 Sugiyama RRM1 RR1 KEKLKDKEKVSKEEEEKERNtAAMVCsLENRDECLMCGS__
P24534 S141 Sugiyama EEF1B2 EEF1B EF1B ERLAQYESKKAKKPALVAKssILLDVKPWDDEtDMAKLEEC
P25788 S243 Sugiyama PSMA3 HC8 PSC8 GRHEIVPKDIREEAEKyAKEsLKEEDEsDDDNM________
P26038 S576 Sugiyama MSN YKtLRQIRQGNTKQRIDEFEsM___________________
P26232 T657 Sugiyama CTNNA2 CAPR EDDsDFEQEDYDVRsRtsVQtEDDQLIAGQsARAIMAQLPQ
P26373 S181 Sugiyama RPL13 BBC1 OK/SW-cl.46 YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26639 T700 Sugiyama TARS1 TARS EKISGTVNIRTRDNKVHGERtIsEtIERLQQLKEFRSKQAE
P27348 S145 Sugiyama YWHAQ YFRyLAEVACGDDRKQtIDNsQGAyQEAFDIsKKEMQPTHP
P27797 S214 Sugiyama CALR CRTC GsLEDDWDFLPPKKIKDPDAsKPEDWDERAKIDDPtDsKPE
P27797 S52 Sugiyama CALR CRTC GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P28066 S174 Sugiyama PSMA5 FHMDPsGtFVQCDARAIGsAsEGAQssLQEVyHKSMTLKEA
P29144 S25 Sugiyama TPP2 ATEEPFPFHGLLPKKETGAAsFLCRYPEYDGRGVLIAVLDt
P29401 S190 Sugiyama TKT ASIYKLDNLVAILDINRLGQsDPAPLQHQMDIyQKRCEAFG
P29401 S295 Sugiyama TKT ysQIQsKKKILAtPPQEDAPsVDIANIRMPsLPsyKVGDKI
P29401 S332 Sugiyama TKT GDKIATRKAYGQALAKLGHAsDRIIALDGDtKNstFsEIFK
P29401 S439 Sugiyama TKT VSIGEDGPSQMALEDLAMFRsVPtstVFyPsDGVAtEKAVE
P29401 S548 Sugiyama TKT NIRVLDPFTIKPLDRKLILDsARAtKGRILTVEDHYYEGGI
P29692 S60 Sugiyama EEF1D EF1D ENGAsVILRDIARARENIQKsLAGssGPGAssGtsGDHGEL
P29692 S64 Sugiyama EEF1D EF1D sVILRDIARARENIQKsLAGssGPGAssGtsGDHGELVVRI
P29692 S71 Sugiyama EEF1D EF1D ARARENIQKsLAGssGPGAssGtsGDHGELVVRIAsLEVEN
P30050 S138 Sugiyama RPL12 HRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDINsG
P30050 S26 Sugiyama RPL12 DPNEIKVVYLRCtGGEVGAtsALAPKIGPLGLsPKKVGDDI
P30084 S107 Sugiyama ECHS1 LTGGDKAFAAGADIKEMQNLsFQDCySSKFLKHWDHLTQVK
P30566 S412 Sugiyama ADSL AMPS AGGSRQDCHEKIRVLsQQAAsVVKQEGGDNDLIERIQVDAY
P33176 S663 Sugiyama KIF5B KNS KNS1 IKSLtEyLQNVEQKKRQLEEsVDALSEELVQLRAQEKVHEM
P33992 S417 Sugiyama MCM5 CDC46 CsPIGVytsGKGSSAAGLtAsVMRDPssRNFIMEGGAMVLA
P33992 T415 Sugiyama MCM5 CDC46 EKCsPIGVytsGKGSSAAGLtAsVMRDPssRNFIMEGGAMV
P34896 S17 Sugiyama SHMT1 ____MTMPVNGAHKDADLWSsHDKMLAQPLKDSDVEVyNII
P34897 S417 Sugiyama SHMT2 ERVLELVSITANKNTCPGDRsAItPGGLRLGAPALtSRQFR
P35221 T658 Sugiyama CTNNA1 LDDsDFEtEDFDVRsRtsVQtEDDQLIAGQsARAIMAQLPQ
P35579 S1376 Sugiyama MYH9 EKQIATLHAQVADMKKKMEDsVGCLEtAEEVKRKLQKDLEG
P35579 S169 Sugiyama MYH9 HIyAITDtAyRSMMQDREDQsILCTGESGAGKTENTKKVIQ
P35606 S350 Sugiyama COPB2 MGDAEIKDGERLPLAVKDMGsCEIyPQtIQHNPNGRFVVVC
P36871 S483 Sugiyama PGM1 DKVYtVEKADNFEysDPVDGsIsRNQGLRLIFTDGSRIVFR
P39023 S265 Sugiyama RPL3 OK/SW-cl.32 HRGLRKVACIGAWHPARVAFsVARAGQKGYHHRTEINKKIY
P43034 S152 Sugiyama PAFAH1B1 LIS1 MDCR MDS PAFAHA IKVWDyEtGDFERtLKGHtDsVQDIsFDHsGKLLASCSADM
P43243 S234 Sugiyama MATR3 KIAA0723 yDRMDyEDDRLRDGERCRDDsFFGEtsHNyHKFDsEyERMG
P43243 S240 Sugiyama MATR3 KIAA0723 EDDRLRDGERCRDDsFFGEtsHNyHKFDsEyERMGRGPGPL
P43243 T239 Sugiyama MATR3 KIAA0723 yEDDRLRDGERCRDDsFFGEtsHNyHKFDsEyERMGRGPGP
P45974 S783 Sugiyama USP5 ISOT IDDLDAEAAMDISEGRsAADsIsEsVPVGPKVRDGPGKYQL
P46060 S454 Sugiyama RANGAP1 KIAA1835 SD VstFLAFPsPEKLLRLGPKssVLIAQQTDTSDPEKVVSAFL
P46777 S172 Sugiyama RPL5 MSTP030 RTTTGNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNA
P46777 S230 Sugiyama RPL5 MSTP030 yLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAHAAIREN
P46782 S75 Sugiyama RPS5 RYAAKRFRKAQCPIVERLtNsMMMHGRNNGKKLMTVRIVKH
P46783 S146 Sugiyama RPS10 TYRRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ_
P47712 S724 Sugiyama PLA2G4A CPLA2 PLA2G4 NIDVIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFL
P47756 S192 Sugiyama CAPZB TVMLWLQTNKSGsGtMNLGGsLtRQMEKDEtVsDCsPHIAN
P48444 S253 Sugiyama ARCN1 COPD KEVDNFVDKLKsEGEtIMSssMGKRTSEATKMHAPPINMES
P48643 S51 Sugiyama CCT5 CCTE KIAA0098 LEALKSHIMAAKAVANtMRtsLGPNGLDKMMVDKDGDVtVT
P48739 S165 Sugiyama PITPNB DRSQVEPADyKADEDPALFQsVKtKRGPLGPNWKKELANsP
P49023 S84 Sugiyama PXN DPLDQWQPSSSRFIHQQPQsssPVyGssAKtssVsNPQDsV
P49023 S91 Sugiyama PXN PSSSRFIHQQPQsssPVyGssAKtssVsNPQDsVGsPCsRV
P49327 S324 Sugiyama FASN FAS ELNGItRALCAtRQEPLLIGsTKSNMGHPEPASGLAALAKV
P49327 S63 Sugiyama FASN FAS GLyGLPRRsGKLKDLSRFDAsFFGVHPKQAHTMDPQLRLLL
P49327 T315 Sugiyama FASN FAS tGTKVGDPQELNGItRALCAtRQEPLLIGsTKSNMGHPEPA
P49589 S305 Sugiyama CARS1 CARS KLVPEAVGDQKALQEGEGDLsIsADRLsEKRSPNDFALWKA
P49589 S34 Sugiyama CARS1 CARS VQPQWsPPAGtQPCRLHLyNsLtRNKEVFIPQDGKKVTWYC
P49792 S1981 Sugiyama RANBP2 NUP358 FGKKDPNFKGFSGAGEKLFSsQYGKMANKANtsGDFEKDDD
P49792 S3137 Sugiyama RANBP2 NUP358 IPDFVCQGGDITKHDGTGGQsIyGDKFEDENFDVKHTGPGL
P50851 S1725 Sugiyama LRBA BGL CDC4L LBA LGALGDLSVEQPVQFRSFDRsVIVAAKKSAVSPSTFNTSIP
P50991 S51 Sugiyama CCT4 CCTD SRB AQIRFsNISAAKAVADAIRtsLGPKGMDKMIQDGKGDVtIt
P51452 S43 Sugiyama DUSP3 VHR YsLPSQPCNEVTPRIyVGNAsVAQDIPKLQKLGITHVLNAA
P51991 S375 Sugiyama HNRNPA3 HNRPA3 ssGsPyGGGyGsGGGsGGyGsRRF_________________
P52272 S528 Sugiyama HNRNPM HNRPM NAGR1 IERMGsGVERMGPAIERMGLsMERMVPAGMGAGLERMGPVM
P52565 S148 Sugiyama ARHGDIA GDIA1 YIQHTyRKGVKIDKtDyMVGsYGPRAEEyEFLtPVEEAPKG
P53396 S478 Sugiyama ACLY EsRADEVAPAKKAKPAMPQDsVPsPRSLQGKSTTLFSRHTK
P54105 S195 Sugiyama CLNS1A CLCI ICLN SHLTAEGQATLERLEGMLsQsVssQYNMAGVRtEDsIRDyE
P55036 S358 Sugiyama PSMD4 MCB1 VLENLPGVDPNNEAIRNAMGsLAsQATKDGKKDKKEEDKK_
P55036 T264 Sugiyama PSMD4 MCB1 AEAGIATTGtEDsDDALLKMtIsQQEFGRTGLPDLSSMTEE
P55060 S342 Sugiyama CSE1L CAS XPO2 ASVCERPHYKNLFEDQNtLtsICEKVIVPNMEFRAADEEAF
P55060 S931 Sugiyama CSE1L CAS XPO2 KKEHDPVGQMVNNPKIHLAQsLHKLSTACPGRVPSMVSTSL
P55072 S765 Sugiyama VCP HEL-220 HEL-S-70 RsVsDNDIRKyEMFAQtLQQsRGFGsFRFPsGNQGGAGPsQ
P55072 T761 Sugiyama VCP HEL-220 HEL-S-70 RFARRsVsDNDIRKyEMFAQtLQQsRGFGsFRFPsGNQGGA
P55769 S118 Sugiyama SNU13 NHP2L1 PVIACSVTIKEGSQLKQQIQsIQQsIERLLV__________
P55884 S185 Sugiyama EIF3B EIF3S9 EEELLGDVLKDRPQEADGIDsVIVVDNVPQVGPDRLEKLKN
P57081 T409 Sugiyama WDR4 RRsPPPGPDGHAKKMRPGEAtLsC_________________
P60174 S236 Sugiyama TPI1 TPI AtCKELASQPDVDGFLVGGAsLKPEFVDIINAKQ_______
P60709 S239 Sugiyama ACTB VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P60709 S368 Sugiyama ACTB sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 S60 Sugiyama ACTB HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P60709 Y53 Sugiyama ACTB sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P61201 S178 Sugiyama COPS2 CSN2 TRIP15 LYLEREEYGKLQKILRQLHQsCQTDDGEDDLKKGTQLLEIY
P61204 S147 Sugiyama ARF3 KQDLPNAMNAAEITDKLGLHsLRHRNWYIQATCATSGDGLY
P61247 S236 Sugiyama RPS3A FTE1 MFTL KMLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGy
P61247 S263 Sugiyama RPS3A FTE1 MFTL GDEtGAKVERADGyEPPVQEsV___________________
P61313 S97 Sugiyama RPL15 EC45 TCBAP0781 KGAtyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLN
P61604 S64 Sugiyama HSPE1 AtVVAVGsGsKGKGGEIQPVsVKVGDKVLLPEyGGtKVVLD
P61978 S420 Sugiyama HNRNPK HNRPK GsIIGKGGQRIKQIRHEsGAsIKIDEPLEGsEDRIITItGt
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61978 S77 Sugiyama HNRNPK HNRPK VIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIETI
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62266 S45 Sugiyama RPS23 KQYKKAHLGtALKANPFGGAsHAKGIVLEKVGVEAKQPNSA
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62701 S204 Sugiyama RPS4X CCG2 RPS4 SCAR tGGANLGRIGVITNRERHPGsFDVVHVKDANGNSFATRLsN
P62736 S241 Sugiyama ACTA2 ACTSA ACTVS GIG46 VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 S62 Sugiyama ACTA2 ACTSA ACTVS GIG46 HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P62736 Y55 Sugiyama ACTA2 ACTSA ACTVS GIG46 sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P62917 S14 Sugiyama RPL8 _______MGRVIRGQRKGAGsVFRAHVKHRKGAARLRAVDF
P63104 S28 Sugiyama YWHAZ QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63104 T30 Sugiyama YWHAZ AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63167 S21 Sugiyama DYNLL1 DLC1 DNCL1 DNCLC1 HDLC1 MCDRKAVIKNADMsEEMQQDsVECAtQALEKYNIEKDIAAH
P63241 S100 Sugiyama EIF5A DVPNIKRNDFQLIGIQDGyLsLLQDSGEVREDLRLPEGDLG
P63261 S239 Sugiyama ACTG1 ACTG VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63261 S368 Sugiyama ACTG1 ACTG sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 S60 Sugiyama ACTG1 ACTG HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P63261 Y53 Sugiyama ACTG1 ACTG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267 S240 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 S61 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P63267 Y54 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68032 S241 Sugiyama ACTC1 ACTC VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 S62 Sugiyama ACTC1 ACTC HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68032 Y55 Sugiyama ACTC1 ACTC sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68104 T432 Sugiyama EEF1A1 EEF1A EF1A LENG7 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
P68133 S241 Sugiyama ACTA1 ACTA VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 S62 Sugiyama ACTA1 ACTA HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68133 Y55 Sugiyama ACTA1 ACTA sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68363 S439 Sugiyama TUBA1B SEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy________
P68363 S48 Sugiyama TUBA1B HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P78371 S144 Sugiyama CCT2 99D8.1 CCTB QTIIAGWREATKAAREALLssAVDHGsDEVKFRQDLMNIAG
P78417 S23 Sugiyama GSTO1 GSTTLP28 GESARsLGKGsAPPGPVPEGsIRIySMRFCPFAERTRLVLK
P84077 S147 Sugiyama ARF1 KQDLPNAMNAAEITDKLGLHsLRHRNWYIQATCATSGDGLY
P99999 S48 Sugiyama CYCS CYC KTGPNLHGLFGRKtGQAPGysytAANKNKGIIWGEDTLMEY
Q00613 S363 Sugiyama HSF1 HSTF1 AsVTALtDARGHTDtEGRPPsPPPtstPEKCLsVACLDKNE
Q01105 S168 Sugiyama SET ENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQN
Q02790 S258 Sugiyama FKBP4 FKBP52 PPNAELKYELHLKSFEKAKEsWEMNsEEKLEQSTIVKERGt
Q04446 S75 Sugiyama GBE1 ILKNIGENEGGIDKFSRGyEsFGVHRCADGGLYCKEWAPGA
Q04726 S205 Sugiyama TLE3 KIAA1547 NHHELDHREREssANNsVsPsEsLRAsEKHRGsADYsMEAK
Q05639 T432 Sugiyama EEF1A2 EEF1AL STN VESFSQYPPLGRFAVRDMRQtVAVGVIKNVEKKSGGAGKVT
Q06124 S28 Sugiyama PTPN11 PTP2C SHPTP2 HPNITGVEAENLLLTRGVDGsFLARPSKSNPGDFTLSVRRN
Q06323 S31 Sugiyama PSME1 IFI5111 QAKVDVFREDLCTKtENLLGsyFPKKIsELDAFLKEPALNE
Q06830 S126 Sugiyama PRDX1 PAGA PAGB TDPX2 SDPKRtIAQDyGVLKADEGIsFRGLFIIDDKGILRQItVND
Q06830 T183 Sugiyama PRDX1 PAGA PAGB TDPX2 FQFtDKHGEVCPAGWKPGsDtIKPDVQKSKEyFSKQK____
Q07866 S524 Sugiyama KLC1 KLC KNS2 QRVAEVLNDPENMEKRRsREsLNVDVVKYESGPDGGEEVSM
Q12792 S142 Sugiyama TWF1 PTK9 FGTVKEDVSLHGYKKyLLsQssPAPLtAAEEELRQIKINEV
Q12906 S20 Sugiyama ILF3 DRBF MPHOSPH4 NF90 _MRPMRIFVNDDRHVMAKHssVyPTQEELEAVQNMVsHtER
Q13247 S303 Sugiyama SRSF6 SFRS6 SRP55 ENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsPPPKRAT
Q13283 S232 Sugiyama G3BP1 G3BP EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q13347 S217 Sugiyama EIF3I EIF3S2 TRIP1 sRDMtMFVtASKDNTAKLFDsttLEHQKTFRTERPVNSAAL
Q13409 S92 Sugiyama DYNC1I2 DNCI2 DNCIC2 ESPIVFSEYWVPPPMsPSSKsVStPsEAGsQDsGDGAVGsR
Q13509 S115 Sugiyama TUBB3 TUBB4 SGAGNNWAKGHytEGAELVDsVLDVVRKECENCDCLQGFQL
Q13509 S75 Sugiyama TUBB3 TUBB4 SSHKYVPRAILVDLEPGtMDsVRSGAFGHLFRPDNFIFGQS
Q13561 T315 Sugiyama DCTN2 DCTN50 KHKASVEDADTQSKVHQLyEtIQRWsPIASTLPELVQRLVT
Q13885 S115 Sugiyama TUBB2A TUBB2 sGAGNNWAKGHytEGAELVDsVLDVVRKESESCDCLQGFQL
Q13885 S75 Sugiyama TUBB2A TUBB2 AGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q14152 S1028 Sugiyama EIF3A EIF3S10 KIAA0139 NWRHADDDRPPRRGLDEDRGsWRtADEDRGPRRGMDDDRGP
Q14152 S584 Sugiyama EIF3A EIF3S10 KIAA0139 EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV
Q14498 S337 Sugiyama RBM39 HCC1 RNPC2 AGRPMKVGHVTERtDAssAssFLDsDELERtGIDLGtTGRL
Q14566 S324 Sugiyama MCM6 APTNPRFGGKELRDEEQtAEsIKNQMTVKEWEKVFEMsQDK
Q14568 S165 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 AEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGERMGRGTK
Q14568 S169 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 TVITKHNDDEQyAWEssAGGsFtVRTDTGERMGRGTKVILH
Q14568 T171 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 ITKHNDDEQyAWEssAGGsFtVRTDTGERMGRGTKVILHLK
Q14677 S166 Sugiyama CLINT1 ENTH EPN4 EPNR KIAA0171 REERKKAKKNKDKyVGVssDsVGGFRysERYDPEPKSKWDE
Q14694 S253 Sugiyama USP10 KIAA0190 GSDTRTAGQPEGGPGADFGQsCFPAEAGRDtLsRTAGAQPC
Q14980 S1149 Sugiyama NUMA1 NMP22 NUMA VSKLEQQCQKQQEQADsLERsLEAERASRAERDsALEtLQG
Q14980 S1181 Sugiyama NUMA1 NMP22 NUMA DsALEtLQGQLEEKAQELGHsQsALAsAQRELAAFRTKVQD
Q14980 S1183 Sugiyama NUMA1 NMP22 NUMA ALEtLQGQLEEKAQELGHsQsALAsAQRELAAFRTKVQDHS
Q14980 S1229 Sugiyama NUMA1 NMP22 NUMA WKAQVARGRQEAERKNsLIssLEEEVSILNRQVLEKEGESK
Q15005 S218 Sugiyama SPCS2 KIAA0102 SPC25 DHSGTLVMDAYEPEISRLHDsLAIERKIK____________
Q15029 T500 Sugiyama EFTUD2 KIAA0031 SNRP116 KMYSTDDGVQFHAFGRVLSGtIHAGQPVKVLGENYTLEDEE
Q15185 S72 Sugiyama PTGES3 P23 TEBP EIDLFHCIDPNDsKHKRtDRsILCCLRKGEsGQsWPRLTKE
Q15758 T532 Sugiyama SLC1A5 ASCT2 M7V1 RDR RDRC VPTEEGNPLLKHyRGPAGDAtVAsEKEsVM___________
Q16401 S98 Sugiyama PSMD5 KIAA0072 VHVARNLRVDLQRGLIHPDDsVKILTLSQIGRIVENSDAVT
Q16658 S259 Sugiyama FSCN1 FAN1 HSN SNL tLKAGKATKVGKDELFALEQsCAQVVLQAANERNVsTRQGM
Q16658 T239 Sugiyama FSCN1 FAN1 HSN SNL GKVAFRDCEGRyLAPsGPsGtLKAGKATKVGKDELFALEQs
Q16719 S456 Sugiyama KYNU APVPLyNsFHDVyKFTNLLtsILDsAETKN___________
Q16719 S460 Sugiyama KYNU LyNsFHDVyKFTNLLtsILDsAETKN_______________
Q3ZCM7 S75 Sugiyama TUBB8 SGGRYVPRAVLVDLEPGtMDsVRSGPFGQVFRPDNFIFGQC
Q4G0X9 S553 Sugiyama CCDC40 KIAA1640 EIEAYKKSIMKEEEKNEKLAsILNRTETEATLLQKLTTQCL
Q4V328 S666 Sugiyama GRIPAP1 KIAA1167 EELVLsEMNsPSRtQtGDsssIssFsYREILREKEssAVPA
Q562R1 S240 Sugiyama ACTBL2 VALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPE
Q58FF7 S370 Sugiyama HSP90AB3P HSP90BC KETQKSTYYITGESKEQVANsAFVERVRKQGFEVVYMTEPI
Q5VTE0 T432 Sugiyama EEF1A1P5 EEF1AL3 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
Q658Y4 S332 Sugiyama FAM91A1 KNVPSVNRLKSTLDPQKMLLsWDGGESRsPVQEAssAtDtD
Q6IBS0 S140 Sugiyama TWF2 PTK9L MSTP011 ELFGTVKDDLSFAGyQKHLssCAAPAPLtsAERELQQIRIN
Q6PEY2 S48 Sugiyama TUBA3E HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q6PHR2 S300 GPS6|SIGNOR|EPSD|PSP ULK3 SLGRATALVVQAVKKDQEGDsAAALsLYCKALDFFVPALHY
Q6PHR2 S305 Sugiyama ULK3 TALVVQAVKKDQEGDsAAALsLYCKALDFFVPALHYEVDAQ
Q6PHR2 S339 Sugiyama ULK3 HYEVDAQRKEAIKAKVGQYVsRAEELKAIVSssNQALLRQG
Q6PHR2 S350 GPS6|SIGNOR|EPSD|PSP ULK3 IKAKVGQYVsRAEELKAIVSssNQALLRQGTSARDLLREMA
Q6PHR2 S351 Sugiyama ULK3 KAKVGQYVsRAEELKAIVSssNQALLRQGTSARDLLREMAR
Q6PHR2 S384 GPS6|SIGNOR|EPSD|PSP ULK3 DLLREMARDKPRLLAALEVAsAAMAKEEAAGGEQDALDLYQ
Q6PHR2 S464 GPS6|SIGNOR|EPSD|PSP|Sugiyama ULK3 VKMRESRWEADTLDKEGLsEsVRSSCTLQ____________
Q6PJT7 S330 Sugiyama ZC3H14 HDGEEEEEDDDYGSRtGsISsSVSVPAKPERRPsLPPSKQA
Q6PKG0 S548 Sugiyama LARP1 KIAA0731 LARP VPtKTEEVSNLKTLPKGLsAsLPDLDsENWIEVKKRPRPSP
Q6S8J3 S1068 Sugiyama POTEE A26C1A POTE2 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q6S8J3 S939 Sugiyama POTEE A26C1A POTE2 VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
Q71RC2 S394 Sugiyama LARP4 PP13296 RVKPQFRssGGsEHstEGsVsLGDGQLNRYSSRNFPAERHN
Q71U36 S439 Sugiyama TUBA1A TUBA3 SEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy________
Q71U36 S48 Sugiyama TUBA1A TUBA3 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q7KZF4 S126 Sugiyama SND1 TDRD11 GREyGMIyLGKDTNGENIAEsLVAEGLAtRREGMRANNPEQ
Q7Z417 S592 Sugiyama NUFIP2 KIAA1321 PIG1 sPQVLGSILKsGttsEsGALsLEPsHIGDLQKADtssQGAL
Q7Z5K2 S231 Sugiyama WAPL FOE KIAA0261 WAPAL WNSQFGKRPEsPsEIsPIKGsVRTGLFEWDNDFEDIRSEDC
Q86UP2 S1181 Sugiyama KTN1 CG1 KIAA0004 ENKWKVKVDESHKTIKQMQssFTSsEQELERLRSENKDIEN
Q86V81 S145 Sugiyama ALYREF ALY BEF THOC4 LFAEFGtLKKAAVHYDRsGRsLGtADVHFERKADALKAMKQ
Q8N684 T203 Sugiyama CPSF7 GGIPPRAHsRDssDsADGRAtPsENLVPSSARVDKPPSVLP
Q8N6T3 S246 Sugiyama ARFGAP1 ARF1GAP KEGATKFGSQASQKASELGHsLNENVLKPAQEKVKEGKIFD
Q8N6T3 S348 Sugiyama ARFGAP1 ARF1GAP FWETFGSAEPTKtRKsPssDsWtCADtstERRssDsWEVWG
Q8NBJ7 S256 Sugiyama SUMF2 PSEC0171 UNQ1968/PRO4500 EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG
Q8NE71 S105 Sugiyama ABCF1 ABC50 KKDVDDDGEEKELMERLKKLsVPtsDEEDEVPAPKPRGGKK
Q8NEB9 S249 PSP PIK3C3 VPS34 KEyGIVYYEKDGDEssPILTsFELVKVPDPQMSMENLVESK
Q8TAM6 S280 Sugiyama ERMN KIAA1189 TISYRKIRKGNTKQRIDEFEsMMHL________________
Q8TEW0 S962 Sugiyama PARD3 PAR3 PAR3A DEGMEtLEEDTEESSRsGREsVstAsDQPsHsLERQMNGNQ
Q8WUM4 S454 Sugiyama PDCD6IP AIP1 ALIX KIAA1375 DQLIKELPELLQRNREILDEsLRLLDEEEAtDNDLRAKFKE
Q8WVV9 S86 Sugiyama HNRNPLL HNRPLL SRRF BLOCK24 GGsHHKVsVsPVVHVRGLCEsVVEADLVEALEKFGTICYVM
Q96D46 S462 Sugiyama NMD3 CGI-07 FLEDLEEDEAIRKNVNIyRDsAIPVEsDtDDEGAPRISLAE
Q96HE7 S143 Sugiyama ERO1A ERO1L UNQ434/PRO865 EANNLIEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSD
Q96IR7 S360 Sugiyama HPDL GLOXD1 LIQRQGATGFGQGNIRALWQsVQEQsARSQEA_________
Q99496 S143 Sugiyama RNF2 BAP1 DING HIPI3 RING1B HQERVLARINKHNNQQALSHsIEEGLKIQAMNRLQRGKKQQ
Q99613 S754 Sugiyama EIF3C EIF3S8 REHVVAASKAMKMGDWKTCHsFIINEKMNGKVWDLFPEADK
Q99613 S865 Sugiyama EIF3C EIF3S8 HRTEPTAQQNLALQLAEKLGsLVENNERVFDHKQGtyGGyF
Q9BQE3 S439 Sugiyama TUBA1C TUBA6 SEAREDMAALEKDyEEVGADsADGEDEGEEy__________
Q9BQE3 S48 Sugiyama TUBA1C TUBA6 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q9BVA1 S115 Sugiyama TUBB2B sGAGNNWAKGHytEGAELVDsVLDVVRKESESCDCLQGFQL
Q9BVA1 S75 Sugiyama TUBB2B tGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q9BXS6 S363 Sugiyama NUSAP1 ANKT BM-037 PRO0310 TtEAtQtPVsNKKPVFDLKAsLsRPLNyEPHKGKLKPWGQS
Q9BYX7 S239 Sugiyama POTEKP ACTBL3 FKSG30 VALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPE
Q9BYX7 S368 Sugiyama POTEKP ACTBL3 FKSG30 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9H2U2 S313 Sugiyama PPA2 HSPC124 VQISDSPFRCtQEEARsLVEsVsssPNKEsNEEEQVWHFLG
Q9H3P7 S316 Sugiyama ACBD3 GCP60 GOCAP1 GOLPH1 QLAQQQAALQKQQEVVVAGssLPtssKVNATVPSNMMSVNG
Q9H3P7 S393 Sugiyama ACBD3 GCP60 GOCAP1 GOLPH1 SMWTRPQIKDFKEKIQQDADsVItVGRGEVVTVRVPTHEEG
Q9H788 S124 Sugiyama SH2D4A PPP1R38 SH2A LKAEQEAEEPRKTHsEEFTNsLKTKsQyHDLQAPDNQQtKD
Q9H8Y5 S75 Sugiyama ANKZF1 ZNF744 EsPERKLLQGPMDISEKLFCsTCDQTFQNHQEQREHYKLDW
Q9NPQ8 S452 Sugiyama RIC8A EGQysEDEDtDtDEyKEAKAsINPVTGRVEEKPPNPMEGMT
Q9NQ39 S157 Sugiyama RPS10P5 RPS10L TYRRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ_
Q9NR30 S706 Sugiyama DDX21 PTASVTEIQEKWHDSRRWQLsVATEQPELEGPREGYGGFRG
Q9NVR5 S773 Sugiyama DNAAF2 C14orf104 KTU EFIKEKSATCSNEEKDNLNEsVITEEKETDGDHLsSLLNKT
Q9P2E9 S872 Sugiyama RRBP1 KIAA1398 RKALEAKAAAFEKQVLQLQAsHRESEEALQKRLDEVSRELC
Q9UBC2 S374 Sugiyama EPS15L1 EPS15R LsPDMVPPsERGtPGPDssGsLGsGEFTGVKELDDISQEIA
Q9UBC2 S479 Sugiyama EPS15L1 EPS15R LRDMLSDVRQKCQDETQMISsLKTQIQSQESDLKsQEDDLN
Q9UGV2 S335 Sugiyama NDRG3 YIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQsDGt
Q9UII2 S39 Sugiyama ATP5IF1 ATPI ATPIF1 TMQARGFGsDQSENVDRGAGsIREAGGAFGKREQAEEERyF
Q9UKV3 S388 Sugiyama ACIN1 ACINUS KIAA0670 EEEEREIKssQGLKEKsKsPsPPRLtEDRKKAsLVALPEQt
Q9UNF0 S273 Sugiyama PACSIN2 KHLDLSNVAGYKAIyHDLEQsIRAADAVEDLRWFRANHGPG
Q9UNW1 S468 Sugiyama MINPP1 MIPP UNQ900/PRO1917 SQETVSFYEDLKNHYKDILQsCQTSEECELARANSTSDEL_
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y4L1 S461 Sugiyama HYOU1 GRP170 HSPH4 ORP150 VVYPILVEFTREVEEEPGIHsLKHNKRVLFSRMGPYPQRKV
Q9Y5S9 S56 Sugiyama RBM8A RBM8 HSPC114 MDS014 KGRGFGsEEGsRARMREDyDsVEQDGDEPGPQRSVEGWILF
Q9Y6D6 S1575 Sugiyama ARFGEF1 ARFGEP1 BIG1 sPVsEKPLDtIsQKsVDIHDsIQPRsVDNRPQAPLVSASAV
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
M Phase R-HSA-68886 1.110223e-16 15.955 0 0
Cell Cycle R-HSA-1640170 7.771561e-16 15.109 0 0
Cell Cycle, Mitotic R-HSA-69278 6.661338e-16 15.176 0 0
Mitotic Prometaphase R-HSA-68877 2.740030e-13 12.562 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.424083e-12 11.846 0 0
Cell-Cell communication R-HSA-1500931 7.349121e-12 11.134 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 7.514256e-11 10.124 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.026792e-10 9.989 0 0
Nervous system development R-HSA-9675108 2.137307e-10 9.670 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 5.219917e-10 9.282 0 0
Axon guidance R-HSA-422475 5.238445e-10 9.281 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 5.914106e-10 9.228 0 0
Cellular responses to stimuli R-HSA-8953897 6.617437e-10 9.179 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 9.213895e-10 9.036 0 0
G2/M Transition R-HSA-69275 1.424437e-09 8.846 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.943749e-09 8.711 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.146682e-09 8.668 0 0
Mitotic Anaphase R-HSA-68882 2.786370e-09 8.555 0 0
Cell junction organization R-HSA-446728 2.726264e-09 8.564 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 3.208309e-09 8.494 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 3.385513e-09 8.470 0 0
Recycling pathway of L1 R-HSA-437239 4.355104e-09 8.361 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 4.232210e-09 8.373 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 4.023233e-09 8.395 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 4.274658e-09 8.369 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 5.849596e-09 8.233 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 6.220640e-09 8.206 0 0
Aggrephagy R-HSA-9646399 6.604279e-09 8.180 0 0
Cellular responses to stress R-HSA-2262752 6.811123e-09 8.167 0 0
Transport of connexons to the plasma membrane R-HSA-190872 7.650222e-09 8.116 0 0
Kinesins R-HSA-983189 1.161936e-08 7.935 0 0
Chromatin organization R-HSA-4839726 1.427367e-08 7.845 0 0
Separation of Sister Chromatids R-HSA-2467813 1.735620e-08 7.761 0 0
Mitotic Prophase R-HSA-68875 2.729948e-08 7.564 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 4.759292e-08 7.322 0 0
COPI-mediated anterograde transport R-HSA-6807878 4.872808e-08 7.312 0 0
Metabolism of RNA R-HSA-8953854 5.131293e-08 7.290 0 0
AURKA Activation by TPX2 R-HSA-8854518 5.733096e-08 7.242 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 6.359149e-08 7.197 0 0
Selective autophagy R-HSA-9663891 6.827335e-08 7.166 0 0
Chromatin modifying enzymes R-HSA-3247509 7.323824e-08 7.135 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 8.032485e-08 7.095 0 0
Cell Cycle Checkpoints R-HSA-69620 9.793950e-08 7.009 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.035836e-07 6.985 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.035836e-07 6.985 0 0
L1CAM interactions R-HSA-373760 1.211952e-07 6.917 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 1.499590e-07 6.824 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.910057e-07 6.719 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 2.021232e-07 6.694 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 2.030930e-07 6.692 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.051372e-07 6.688 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 2.463153e-07 6.609 0 0
HCMV Early Events R-HSA-9609690 2.648801e-07 6.577 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 3.003626e-07 6.522 0 0
mRNA Splicing R-HSA-72172 3.382999e-07 6.471 0 0
Centrosome maturation R-HSA-380287 4.652098e-07 6.332 0 0
Regulation of endogenous retroelements R-HSA-9842860 4.823584e-07 6.317 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 5.047559e-07 6.297 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 5.970337e-07 6.224 0 0
Chaperonin-mediated protein folding R-HSA-390466 6.062166e-07 6.217 0 0
Signal Transduction R-HSA-162582 6.665382e-07 6.176 1 0
Autophagy R-HSA-9612973 6.987060e-07 6.156 0 0
Cilium Assembly R-HSA-5617833 7.262112e-07 6.139 0 0
Adherens junctions interactions R-HSA-418990 7.612005e-07 6.119 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 8.898394e-07 6.051 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.035216e-06 5.985 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.029791e-06 5.987 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.061688e-06 5.974 0 0
Cell-cell junction organization R-HSA-421270 1.132608e-06 5.946 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.212129e-06 5.916 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.212129e-06 5.916 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.496444e-06 5.825 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.821245e-06 5.740 0 0
Protein folding R-HSA-391251 1.856770e-06 5.731 0 0
HCMV Infection R-HSA-9609646 2.209393e-06 5.656 0 0
G2/M Checkpoints R-HSA-69481 2.310609e-06 5.636 0 0
Gap junction trafficking and regulation R-HSA-157858 2.583323e-06 5.588 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 2.806653e-06 5.552 0 0
Gap junction trafficking R-HSA-190828 2.815984e-06 5.550 0 0
HDACs deacetylate histones R-HSA-3214815 2.927055e-06 5.534 0 0
MHC class II antigen presentation R-HSA-2132295 2.946852e-06 5.531 0 0
Macroautophagy R-HSA-1632852 3.266243e-06 5.486 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 3.277254e-06 5.484 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 3.644433e-06 5.438 0 0
Nucleosome assembly R-HSA-774815 3.644433e-06 5.438 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 4.018996e-06 5.396 0 0
PKR-mediated signaling R-HSA-9833482 4.147648e-06 5.382 0 0
Apoptotic execution phase R-HSA-75153 4.686602e-06 5.329 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 5.745742e-06 5.241 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 6.135266e-06 5.212 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 6.559898e-06 5.183 0 0
Membrane Trafficking R-HSA-199991 6.875708e-06 5.163 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 7.127434e-06 5.147 0 0
Translation initiation complex formation R-HSA-72649 8.339650e-06 5.079 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 8.563505e-06 5.067 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 8.802287e-06 5.055 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 9.759970e-06 5.011 0 0
Gap junction assembly R-HSA-190861 9.759970e-06 5.011 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.202178e-05 4.920 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.286067e-05 4.891 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.309437e-05 4.883 0 0
Viral Infection Pathways R-HSA-9824446 1.300617e-05 4.886 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.585932e-05 4.800 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.946991e-05 4.711 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.924542e-05 4.716 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.924542e-05 4.716 0 0
ER to Golgi Anterograde Transport R-HSA-199977 1.934489e-05 4.713 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.320719e-05 4.634 0 0
Meiotic synapsis R-HSA-1221632 2.321638e-05 4.634 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 2.323816e-05 4.634 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 2.376488e-05 4.624 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.652911e-05 4.576 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 3.173487e-05 4.498 0 0
DNA Double Strand Break Response R-HSA-5693606 3.441956e-05 4.463 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 4.240385e-05 4.373 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 4.573585e-05 4.340 0 0
Post NMDA receptor activation events R-HSA-438064 4.725444e-05 4.326 0 0
HATs acetylate histones R-HSA-3214847 5.225229e-05 4.282 0 0
Diseases of programmed cell death R-HSA-9645723 5.506151e-05 4.259 0 0
Interleukin-12 signaling R-HSA-9020591 5.506477e-05 4.259 0 0
HIV Life Cycle R-HSA-162587 6.025659e-05 4.220 0 0
PRC2 methylates histones and DNA R-HSA-212300 6.570749e-05 4.182 0 0
Cell-extracellular matrix interactions R-HSA-446353 8.666919e-05 4.062 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 8.021169e-05 4.096 0 0
DNA Double-Strand Break Repair R-HSA-5693532 8.675489e-05 4.062 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 8.682742e-05 4.061 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 8.846357e-05 4.053 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 9.388413e-05 4.027 0 0
Programmed Cell Death R-HSA-5357801 9.440483e-05 4.025 0 0
Deubiquitination R-HSA-5688426 1.182886e-04 3.927 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.193074e-04 3.923 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.200782e-04 3.921 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.311961e-04 3.882 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.315085e-04 3.881 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.315085e-04 3.881 0 0
Ub-specific processing proteases R-HSA-5689880 1.581692e-04 3.801 0 0
HIV Infection R-HSA-162906 1.633736e-04 3.787 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.634997e-04 3.786 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 1.682559e-04 3.774 0 0
Gene Silencing by RNA R-HSA-211000 1.727575e-04 3.763 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.869498e-04 3.728 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.869498e-04 3.728 0 0
mRNA 3'-end processing R-HSA-72187 2.003670e-04 3.698 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 2.042235e-04 3.690 0 0
Cellular response to heat stress R-HSA-3371556 2.106939e-04 3.676 0 0
Apoptosis R-HSA-109581 2.169779e-04 3.664 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.208188e-04 3.656 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 2.473680e-04 3.607 0 0
Influenza Infection R-HSA-168255 2.767050e-04 3.558 0 0
Signaling by ROBO receptors R-HSA-376176 2.877834e-04 3.541 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 2.975243e-04 3.526 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.975243e-04 3.526 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.999780e-04 3.523 0 0
Developmental Biology R-HSA-1266738 3.046434e-04 3.516 0 0
Packaging Of Telomere Ends R-HSA-171306 3.156653e-04 3.501 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 3.156653e-04 3.501 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 3.220959e-04 3.492 0 0
Interleukin-12 family signaling R-HSA-447115 3.279333e-04 3.484 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 3.619021e-04 3.441 0 0
Organelle biogenesis and maintenance R-HSA-1852241 3.692484e-04 3.433 0 0
Hedgehog 'off' state R-HSA-5610787 3.707544e-04 3.431 0 0
SARS-CoV-1-host interactions R-HSA-9692914 3.636257e-04 3.439 0 0
ChREBP activates metabolic gene expression R-HSA-163765 3.778338e-04 3.423 0 0
SARS-CoV-1 Infection R-HSA-9678108 3.892008e-04 3.410 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 4.493710e-04 3.347 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 4.583932e-04 3.339 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 4.715936e-04 3.326 0 0
Regulation of CDH1 Function R-HSA-9764561 4.743341e-04 3.324 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 4.804235e-04 3.318 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 4.843242e-04 3.315 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 5.677720e-04 3.246 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 5.677720e-04 3.246 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 5.677720e-04 3.246 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 5.677720e-04 3.246 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 5.677720e-04 3.246 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 5.677720e-04 3.246 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 5.677720e-04 3.246 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 5.677720e-04 3.246 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 5.677720e-04 3.246 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 5.677720e-04 3.246 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 5.677720e-04 3.246 0 0
DNA methylation R-HSA-5334118 5.119946e-04 3.291 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 5.471657e-04 3.262 0 0
Meiosis R-HSA-1500620 5.524833e-04 3.258 0 0
Nuclear import of Rev protein R-HSA-180746 5.422956e-04 3.266 0 0
RNA Polymerase I Transcription R-HSA-73864 5.471910e-04 3.262 0 0
DNA Replication Pre-Initiation R-HSA-69002 5.144344e-04 3.289 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 5.444431e-04 3.264 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 5.422956e-04 3.266 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 5.922395e-04 3.228 0 0
Late Phase of HIV Life Cycle R-HSA-162599 6.023836e-04 3.220 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 6.264543e-04 3.203 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 6.287985e-04 3.201 0 0
Amplification of signal from the kinetochores R-HSA-141424 6.287985e-04 3.201 0 0
Nephrin family interactions R-HSA-373753 6.315713e-04 3.200 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 6.380644e-04 3.195 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 6.432217e-04 3.192 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 6.623696e-04 3.179 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 6.670003e-04 3.176 0 0
Eukaryotic Translation Elongation R-HSA-156842 7.045094e-04 3.152 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 8.013064e-04 3.096 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 8.013064e-04 3.096 0 0
Signaling by RAF1 mutants R-HSA-9656223 7.973619e-04 3.098 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 7.172857e-04 3.144 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 7.172857e-04 3.144 0 0
MAP2K and MAPK activation R-HSA-5674135 7.973619e-04 3.098 0 0
Homology Directed Repair R-HSA-5693538 7.607396e-04 3.119 0 0
Processing of DNA double-strand break ends R-HSA-5693607 8.151790e-04 3.089 0 0
Glycolysis R-HSA-70171 8.669787e-04 3.062 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 8.827462e-04 3.054 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 8.883414e-04 3.051 0 0
Intraflagellar transport R-HSA-5620924 8.994005e-04 3.046 0 0
Gene expression (Transcription) R-HSA-74160 9.254966e-04 3.034 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 9.903216e-04 3.004 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.057333e-03 2.976 0 0
Defective pyroptosis R-HSA-9710421 1.137307e-03 2.944 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.214718e-03 2.916 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.214718e-03 2.916 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 1.214718e-03 2.916 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.289789e-03 2.889 0 0
mTORC1-mediated signalling R-HSA-166208 1.376707e-03 2.861 0 0
Meiotic recombination R-HSA-912446 1.456712e-03 2.837 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.479327e-03 2.830 0 0
Regulation of TP53 Activity R-HSA-5633007 1.490151e-03 2.827 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.538501e-03 2.813 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.707049e-03 2.768 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.789361e-03 2.747 0 0
Signaling by RAS mutants R-HSA-6802949 1.867729e-03 2.729 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.867729e-03 2.729 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.867729e-03 2.729 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.867729e-03 2.729 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.891122e-03 2.723 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 2.145909e-03 2.668 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.944256e-03 2.711 0 0
PKMTs methylate histone lysines R-HSA-3214841 2.025066e-03 2.694 0 0
Vesicle-mediated transport R-HSA-5653656 2.186387e-03 2.660 0 0
Protein ubiquitination R-HSA-8852135 2.274746e-03 2.643 0 0
Formation of a pool of free 40S subunits R-HSA-72689 2.527734e-03 2.597 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.559215e-03 2.592 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 2.806840e-03 2.552 0 0
Depyrimidination R-HSA-73928 2.806840e-03 2.552 0 0
Semaphorin interactions R-HSA-373755 3.011588e-03 2.521 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 3.049744e-03 2.516 0 0
Cleavage of the damaged purine R-HSA-110331 3.049744e-03 2.516 0 0
Glucose metabolism R-HSA-70326 3.069668e-03 2.513 0 0
Oncogenic MAPK signaling R-HSA-6802957 3.107600e-03 2.508 0 0
Signaling by Hedgehog R-HSA-5358351 3.138824e-03 2.503 1 0
Transport to the Golgi and subsequent modification R-HSA-948021 3.211653e-03 2.493 0 0
Interferon Signaling R-HSA-913531 3.244251e-03 2.489 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 3.288984e-03 2.483 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 3.346610e-03 2.475 0 0
Depurination R-HSA-73927 3.601009e-03 2.444 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 3.601009e-03 2.444 0 0
ESR-mediated signaling R-HSA-8939211 3.674008e-03 2.435 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 4.051561e-03 2.392 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 4.273920e-03 2.369 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 4.273920e-03 2.369 0 0
Signaling by ALK in cancer R-HSA-9700206 4.273920e-03 2.369 0 0
snRNP Assembly R-HSA-191859 4.465633e-03 2.350 0 0
Metabolism of non-coding RNA R-HSA-194441 4.465633e-03 2.350 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 4.490970e-03 2.348 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 4.490970e-03 2.348 0 0
Striated Muscle Contraction R-HSA-390522 4.606981e-03 2.337 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 5.391374e-03 2.268 0 0
Peptide chain elongation R-HSA-156902 4.748530e-03 2.323 0 0
MITF-M-dependent gene expression R-HSA-9856651 4.625999e-03 2.335 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 5.169805e-03 2.287 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 5.529206e-03 2.257 0 0
TCF dependent signaling in response to WNT R-HSA-201681 4.895693e-03 2.310 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 5.180693e-03 2.286 0 0
Unwinding of DNA R-HSA-176974 5.487559e-03 2.261 0 0
ISG15 antiviral mechanism R-HSA-1169408 5.293429e-03 2.276 0 0
Cytokine Signaling in Immune system R-HSA-1280215 4.922719e-03 2.308 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 5.373202e-03 2.270 0 0
Host Interactions of HIV factors R-HSA-162909 5.628730e-03 2.250 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 5.745830e-03 2.241 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 5.745830e-03 2.241 0 0
Late endosomal microautophagy R-HSA-9615710 5.868661e-03 2.231 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 5.868661e-03 2.231 0 0
Synaptic adhesion-like molecules R-HSA-8849932 6.047205e-03 2.218 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 6.398399e-03 2.194 0 0
tRNA processing in the nucleus R-HSA-6784531 6.443904e-03 2.191 0 0
SARS-CoV Infections R-HSA-9679506 6.477348e-03 2.189 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 6.811479e-03 2.167 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 6.811479e-03 2.167 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 6.811479e-03 2.167 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 7.040841e-03 2.152 0 0
G alpha (12/13) signalling events R-HSA-416482 7.288443e-03 2.137 0 0
Neurodegenerative Diseases R-HSA-8863678 7.424903e-03 2.129 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 7.424903e-03 2.129 0 0
Folding of actin by CCT/TriC R-HSA-390450 7.603132e-03 2.119 0 0
HCMV Late Events R-HSA-9610379 7.691145e-03 2.114 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 7.717534e-03 2.113 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 8.257520e-03 2.083 0 0
Chromosome Maintenance R-HSA-73886 8.487091e-03 2.071 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 8.583739e-03 2.066 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 8.583739e-03 2.066 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 8.925092e-03 2.049 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 9.027458e-03 2.044 0 0
Ribosome-associated quality control R-HSA-9948299 1.101168e-02 1.958 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.113159e-02 1.953 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.132154e-02 1.946 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.142348e-02 1.942 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.142348e-02 1.942 0 0
Signaling by VEGF R-HSA-194138 1.241953e-02 1.906 0 0
Smooth Muscle Contraction R-HSA-445355 1.248655e-02 1.904 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.258732e-02 1.900 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.294848e-02 1.888 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.316288e-02 1.881 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.324069e-02 1.878 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.341524e-02 1.872 0 0
Integration of provirus R-HSA-162592 1.341524e-02 1.872 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.341524e-02 1.872 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.364512e-02 1.865 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 1.399914e-02 1.854 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.442118e-02 1.841 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.459572e-02 1.836 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.474294e-02 1.831 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.497120e-02 1.825 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.497120e-02 1.825 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.497120e-02 1.825 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.497120e-02 1.825 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.497120e-02 1.825 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.721109e-02 1.764 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.721109e-02 1.764 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.741229e-02 1.759 0 0
EPH-Ephrin signaling R-HSA-2682334 1.562514e-02 1.806 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 1.581970e-02 1.801 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.596224e-02 1.797 0 0
RNA Polymerase II Transcription R-HSA-73857 1.646904e-02 1.783 0 0
Signaling by Hippo R-HSA-2028269 1.734515e-02 1.761 0 0
DNA Replication R-HSA-69306 1.810470e-02 1.742 0 0
Reproduction R-HSA-1474165 1.892613e-02 1.723 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.963568e-02 1.707 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.963568e-02 1.707 0 0
Type I hemidesmosome assembly R-HSA-446107 1.966973e-02 1.706 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.966973e-02 1.706 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.966973e-02 1.706 0 0
Adrenoceptors R-HSA-390696 1.966973e-02 1.706 0 0
Amyloid fiber formation R-HSA-977225 2.030732e-02 1.692 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.100667e-02 1.678 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.100667e-02 1.678 0 0
Eukaryotic Translation Termination R-HSA-72764 2.160965e-02 1.665 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.215333e-02 1.655 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.261804e-02 1.646 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.282752e-02 1.642 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 2.282752e-02 1.642 0 0
Co-inhibition by PD-1 R-HSA-389948 2.284557e-02 1.641 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.440165e-02 1.613 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 2.440165e-02 1.613 0 0
MAPK family signaling cascades R-HSA-5683057 2.441891e-02 1.612 0 0
SARS-CoV-2-host interactions R-HSA-9705683 2.528026e-02 1.597 0 0
Orc1 removal from chromatin R-HSA-68949 2.553334e-02 1.593 0 0
Signaling by Interleukins R-HSA-449147 2.595402e-02 1.586 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.595932e-02 1.586 0 0
Regulation of PTEN gene transcription R-HSA-8943724 2.616694e-02 1.582 0 0
SARS-CoV-2 Infection R-HSA-9694516 2.641466e-02 1.578 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.642155e-02 1.578 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.742565e-02 1.562 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 2.763010e-02 1.559 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 2.763010e-02 1.559 0 0
IRS activation R-HSA-74713 2.763010e-02 1.559 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 2.763010e-02 1.559 0 0
NrCAM interactions R-HSA-447038 2.763010e-02 1.559 0 0
Viral Messenger RNA Synthesis R-HSA-168325 2.877426e-02 1.541 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 2.885162e-02 1.540 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.982330e-02 1.525 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 3.006049e-02 1.522 0 0
rRNA processing R-HSA-72312 3.054018e-02 1.515 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 3.057461e-02 1.515 0 0
Manipulation of host energy metabolism R-HSA-9636667 3.172200e-02 1.499 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 3.172200e-02 1.499 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 3.172200e-02 1.499 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 3.172200e-02 1.499 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.172200e-02 1.499 0 0
Translation R-HSA-72766 3.196862e-02 1.495 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 3.252629e-02 1.488 0 0
Cellular Senescence R-HSA-2559583 3.263420e-02 1.486 0 0
Erythropoietin activates RAS R-HSA-9027284 3.263797e-02 1.486 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 3.263797e-02 1.486 0 0
DCC mediated attractive signaling R-HSA-418885 3.263797e-02 1.486 0 0
2-LTR circle formation R-HSA-164843 3.332712e-02 1.477 0 0
Regulation of CDH11 function R-HSA-9762292 3.332712e-02 1.477 0 0
Early Phase of HIV Life Cycle R-HSA-162594 3.502156e-02 1.456 0 0
Basigin interactions R-HSA-210991 3.502156e-02 1.456 0 0
Interaction between L1 and Ankyrins R-HSA-445095 3.514653e-02 1.454 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 3.619891e-02 1.441 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 3.660751e-02 1.436 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 3.732034e-02 1.428 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 3.778109e-02 1.423 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 3.859583e-02 1.413 0 0
Prolonged ERK activation events R-HSA-169893 3.922304e-02 1.406 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 3.922917e-02 1.406 0 0
DNA Repair R-HSA-73894 3.978738e-02 1.400 0 0
Cellular response to starvation R-HSA-9711097 4.000850e-02 1.398 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 4.076966e-02 1.390 0 0
Regulation of TP53 Expression R-HSA-6804754 5.313358e-02 1.275 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 5.313358e-02 1.275 0 0
Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) R-HSA-1299308 5.313358e-02 1.275 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 5.144375e-02 1.289 0 0
Signaling by GSK3beta mutants R-HSA-5339716 5.136350e-02 1.289 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 5.465955e-02 1.262 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 5.465955e-02 1.262 0 0
Activation of the pre-replicative complex R-HSA-68962 5.149156e-02 1.288 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 5.438753e-02 1.265 0 0
Regulation of TP53 Degradation R-HSA-6804757 4.824970e-02 1.317 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 4.708065e-02 1.327 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 4.824970e-02 1.317 0 0
Activation of HOX genes during differentiation R-HSA-5619507 4.406361e-02 1.356 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 4.406361e-02 1.356 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 5.144375e-02 1.289 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 4.498280e-02 1.347 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 4.316024e-02 1.365 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 4.559466e-02 1.341 0 0
MTOR signalling R-HSA-165159 4.473428e-02 1.349 0 0
Signaling by NOTCH R-HSA-157118 4.354342e-02 1.361 0 0
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization R-HSA-180897 5.313358e-02 1.275 0 0
Platelet degranulation R-HSA-114608 4.358351e-02 1.361 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 4.304070e-02 1.366 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 4.730254e-02 1.325 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 4.656073e-02 1.332 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 5.469897e-02 1.262 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 5.702142e-02 1.244 0 0
Selenocysteine synthesis R-HSA-2408557 5.932294e-02 1.227 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 5.933745e-02 1.227 0 0
Signaling by Nuclear Receptors R-HSA-9006931 6.098498e-02 1.215 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 6.142536e-02 1.212 0 0
Deadenylation of mRNA R-HSA-429947 6.142536e-02 1.212 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 6.142536e-02 1.212 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 6.202719e-02 1.207 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 6.202719e-02 1.207 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 6.202719e-02 1.207 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 6.202719e-02 1.207 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 6.202719e-02 1.207 0 0
Sensory processing of sound R-HSA-9659379 6.334475e-02 1.198 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 6.352136e-02 1.197 0 0
Platelet sensitization by LDL R-HSA-432142 6.352136e-02 1.197 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 6.352136e-02 1.197 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 6.417698e-02 1.193 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 6.417698e-02 1.193 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 6.417698e-02 1.193 0 0
G1/S Transition R-HSA-69206 6.417698e-02 1.193 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 6.457163e-02 1.190 0 0
Infectious disease R-HSA-5663205 6.580919e-02 1.182 0 0
Signaling by WNT R-HSA-195721 6.598801e-02 1.181 0 0
SOS-mediated signalling R-HSA-112412 6.608376e-02 1.180 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 6.608376e-02 1.180 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 6.608376e-02 1.180 0 0
Viral mRNA Translation R-HSA-192823 6.696748e-02 1.174 0 0
Signaling by PTK6 R-HSA-8848021 6.808568e-02 1.167 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 6.808568e-02 1.167 0 0
Sema4D in semaphorin signaling R-HSA-400685 6.946703e-02 1.158 0 0
Long-term potentiation R-HSA-9620244 6.946703e-02 1.158 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 7.195207e-02 1.143 0 0
Maturation of nucleoprotein R-HSA-9694631 7.314166e-02 1.136 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 7.376199e-02 1.132 0 0
Frs2-mediated activation R-HSA-170968 7.376199e-02 1.132 0 0
Switching of origins to a post-replicative state R-HSA-69052 7.581544e-02 1.120 0 0
Platelet activation, signaling and aggregation R-HSA-76002 7.792169e-02 1.108 0 0
Gluconeogenesis R-HSA-70263 7.799831e-02 1.108 0 0
Myogenesis R-HSA-525793 7.808760e-02 1.107 0 0
Base Excision Repair R-HSA-73884 7.863477e-02 1.104 0 0
Telomere Maintenance R-HSA-157579 7.931305e-02 1.101 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 7.970428e-02 1.099 0 0
Resolution of D-Loop Structures R-HSA-5693537 7.970428e-02 1.099 0 0
Signaling by NOTCH4 R-HSA-9013694 8.117144e-02 1.091 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 8.239850e-02 1.084 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 8.239850e-02 1.084 0 0
Formation of definitive endoderm R-HSA-9823730 8.350994e-02 1.078 0 0
Degradation of CDH1 R-HSA-9766229 8.469957e-02 1.072 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 8.653378e-02 1.063 0 0
CRMPs in Sema3A signaling R-HSA-399956 8.653378e-02 1.063 0 0
Signal regulatory protein family interactions R-HSA-391160 8.653378e-02 1.063 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 8.728223e-02 1.059 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 8.787049e-02 1.056 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 8.787049e-02 1.056 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 8.787049e-02 1.056 0 0
RAF activation R-HSA-5673000 8.792133e-02 1.056 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 8.792133e-02 1.056 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 8.792133e-02 1.056 0 0
Hemostasis R-HSA-109582 8.803709e-02 1.055 0 0
Cellular response to chemical stress R-HSA-9711123 8.827965e-02 1.054 0 0
PTEN Regulation R-HSA-6807070 9.054370e-02 1.043 0 0
Regulation of RAS by GAPs R-HSA-5658442 9.173464e-02 1.037 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.062800e-01 0.974 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 1.062800e-01 0.974 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.062800e-01 0.974 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 1.062800e-01 0.974 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.364956e-01 0.865 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 1.364956e-01 0.865 0 0
ARMS-mediated activation R-HSA-170984 1.002514e-01 0.999 0 0
Gap junction degradation R-HSA-190873 1.002514e-01 0.999 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.194933e-01 0.923 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 1.194933e-01 0.923 0 0
PECAM1 interactions R-HSA-210990 1.399675e-01 0.854 0 0
Signaling by APC mutants R-HSA-4839744 1.399675e-01 0.854 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.399675e-01 0.854 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.399675e-01 0.854 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.399675e-01 0.854 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.002985e-01 0.999 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.002985e-01 0.999 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 1.150037e-01 0.939 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.150037e-01 0.939 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 9.461005e-02 1.024 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 9.461005e-02 1.024 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.461005e-02 1.024 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.064207e-01 0.973 0 0
HIV elongation arrest and recovery R-HSA-167287 9.704279e-02 1.013 0 0
Pausing and recovery of HIV elongation R-HSA-167290 9.704279e-02 1.013 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.073580e-01 0.969 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.182136e-01 0.927 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 9.459814e-02 1.024 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.391841e-01 0.856 0 0
Transcription of the HIV genome R-HSA-167172 9.729175e-02 1.012 0 0
Nuclear Receptor transcription pathway R-HSA-383280 1.049218e-01 0.979 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 1.305899e-01 0.884 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 1.171993e-01 0.931 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.194933e-01 0.923 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.002985e-01 0.999 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.153114e-01 0.938 0 0
Stabilization of p53 R-HSA-69541 1.357684e-01 0.867 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.182136e-01 0.927 0 0
Budding and maturation of HIV virion R-HSA-162588 1.295926e-01 0.887 0 0
Trafficking of AMPA receptors R-HSA-399719 1.295926e-01 0.887 0 0
HSF1-dependent transactivation R-HSA-3371571 9.910225e-02 1.004 0 0
Proteasome assembly R-HSA-9907900 1.113183e-01 0.953 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 9.508832e-02 1.022 0 0
Protein-protein interactions at synapses R-HSA-6794362 9.355347e-02 1.029 0 0
Pyrophosphate hydrolysis R-HSA-71737 1.364956e-01 0.865 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.399675e-01 0.854 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.002985e-01 0.999 0 0
Somitogenesis R-HSA-9824272 1.202428e-01 0.920 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 1.364956e-01 0.865 0 0
Signal attenuation R-HSA-74749 1.194933e-01 0.923 0 0
Protein methylation R-HSA-8876725 1.002985e-01 0.999 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.299485e-01 0.886 0 0
Regulated Necrosis R-HSA-5218859 9.729175e-02 1.012 0 0
MTF1 activates gene expression R-HSA-5660489 1.062800e-01 0.974 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.002514e-01 0.999 0 0
Ionotropic activity of kainate receptors R-HSA-451306 1.399675e-01 0.854 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 1.150037e-01 0.939 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.125882e-01 0.949 0 0
S Phase R-HSA-69242 1.390428e-01 0.857 0 0
Suppression of apoptosis R-HSA-9635465 1.399675e-01 0.854 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 1.391841e-01 0.856 0 0
FLT3 signaling in disease R-HSA-9682385 1.057320e-01 0.976 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.002985e-01 0.999 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 9.459814e-02 1.024 0 0
Activation of BH3-only proteins R-HSA-114452 1.182136e-01 0.927 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.323689e-01 0.878 0 0
Muscle contraction R-HSA-397014 1.315257e-01 0.881 0 0
Downstream signal transduction R-HSA-186763 1.295926e-01 0.887 0 0
Potential therapeutics for SARS R-HSA-9679191 1.021089e-01 0.991 0 0
RMTs methylate histone arginines R-HSA-3214858 1.113183e-01 0.953 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 1.068001e-01 0.971 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.107841e-01 0.956 0 0
Co-inhibition by BTLA R-HSA-9927353 1.364956e-01 0.865 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.194933e-01 0.923 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.064207e-01 0.973 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.329301e-01 0.876 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 9.461005e-02 1.024 0 0
Signaling by Leptin R-HSA-2586552 1.194933e-01 0.923 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.320654e-01 0.879 0 0
NRAGE signals death through JNK R-HSA-193648 1.408101e-01 0.851 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 1.414754e-01 0.849 0 0
DNA strand elongation R-HSA-69190 1.414754e-01 0.849 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.434495e-01 0.843 0 0
Thromboxane signalling through TP receptor R-HSA-428930 1.458356e-01 0.836 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 1.466207e-01 0.834 0 0
Attenuation phase R-HSA-3371568 1.466207e-01 0.834 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.469924e-01 0.833 0 0
Generic Transcription Pathway R-HSA-212436 1.503677e-01 0.823 0 0
Regulation of necroptotic cell death R-HSA-5675482 1.538404e-01 0.813 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 1.538404e-01 0.813 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.538404e-01 0.813 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.538404e-01 0.813 0 0
UCH proteinases R-HSA-5689603 1.572855e-01 0.803 0 0
Interleukin-1 signaling R-HSA-9020702 1.576840e-01 0.802 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 1.578692e-01 0.802 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 1.615145e-01 0.792 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.615145e-01 0.792 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.615145e-01 0.792 0 0
Signaling by AXIN mutants R-HSA-4839735 1.615145e-01 0.792 0 0
MyD88-independent TLR4 cascade R-HSA-166166 1.616510e-01 0.791 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 1.616510e-01 0.791 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.641419e-01 0.785 0 0
Ephrin signaling R-HSA-3928664 1.641419e-01 0.785 0 0
GAB1 signalosome R-HSA-180292 1.641419e-01 0.785 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.660926e-01 0.780 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 1.666636e-01 0.778 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 1.666636e-01 0.778 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.680245e-01 0.775 0 0
SARS-CoV-1 targets PDZ proteins in cell-cell junction R-HSA-9692912 1.680245e-01 0.775 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.680245e-01 0.775 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.680245e-01 0.775 0 0
Defective F8 binding to von Willebrand factor R-HSA-9672393 1.680245e-01 0.775 0 0
Activation and oligomerization of BAK protein R-HSA-111452 1.680245e-01 0.775 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 1.680245e-01 0.775 0 0
Inhibition of PKR R-HSA-169131 1.680245e-01 0.775 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 1.683040e-01 0.774 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 1.683040e-01 0.774 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 1.683040e-01 0.774 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 1.683040e-01 0.774 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.683040e-01 0.774 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 1.683040e-01 0.774 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 1.683040e-01 0.774 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.694973e-01 0.771 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 1.716524e-01 0.765 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.716524e-01 0.765 0 0
Death Receptor Signaling R-HSA-73887 1.741566e-01 0.759 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.746602e-01 0.758 0 0
Signaling by EGFR in Cancer R-HSA-1643713 1.750873e-01 0.757 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.750873e-01 0.757 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 1.799193e-01 0.745 0 0
Signal amplification R-HSA-392518 1.799193e-01 0.745 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 1.799193e-01 0.745 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 1.799193e-01 0.745 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 1.814871e-01 0.741 0 0
Regulation of signaling by CBL R-HSA-912631 1.819664e-01 0.740 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.819664e-01 0.740 0 0
The NLRP3 inflammasome R-HSA-844456 1.819664e-01 0.740 0 0
Rap1 signalling R-HSA-392517 1.819664e-01 0.740 0 0
Scavenging by Class F Receptors R-HSA-3000484 1.839752e-01 0.735 0 0
Regulation of IFNG signaling R-HSA-877312 1.839752e-01 0.735 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 1.839752e-01 0.735 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.839752e-01 0.735 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 1.870734e-01 0.728 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 1.870734e-01 0.728 0 0
Formation of paraxial mesoderm R-HSA-9793380 1.900529e-01 0.721 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.904876e-01 0.720 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.904876e-01 0.720 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.904876e-01 0.720 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 1.904876e-01 0.720 0 0
Insulin processing R-HSA-264876 1.904876e-01 0.720 0 0
Signalling to ERKs R-HSA-187687 1.935805e-01 0.713 0 0
Signaling by SCF-KIT R-HSA-1433557 1.938196e-01 0.713 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 1.963114e-01 0.707 0 0
Signaling by NTRKs R-HSA-166520 1.988288e-01 0.702 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 2.003920e-01 0.698 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 2.003920e-01 0.698 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 2.003920e-01 0.698 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 2.003920e-01 0.698 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 2.003920e-01 0.698 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 2.003920e-01 0.698 0 0
Signaling by NODAL R-HSA-1181150 2.003920e-01 0.698 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 2.011924e-01 0.696 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.011924e-01 0.696 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 2.011924e-01 0.696 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 2.011924e-01 0.696 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.011924e-01 0.696 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 2.039830e-01 0.690 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 2.063469e-01 0.685 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 2.063469e-01 0.685 0 0
Pyroptosis R-HSA-5620971 2.063469e-01 0.685 0 0
Netrin-1 signaling R-HSA-373752 2.064748e-01 0.685 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 2.070837e-01 0.684 0 0
Formation of axial mesoderm R-HSA-9796292 2.071938e-01 0.684 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 2.071938e-01 0.684 0 0
Maturation of nucleoprotein R-HSA-9683610 2.071938e-01 0.684 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 2.071938e-01 0.684 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 2.071938e-01 0.684 0 0
HSF1 activation R-HSA-3371511 2.076186e-01 0.683 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.411393e-01 0.618 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 2.411393e-01 0.618 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.411393e-01 0.618 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.411393e-01 0.618 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 2.411393e-01 0.618 0 0
Defective VWF binding to collagen type I R-HSA-9845622 2.411393e-01 0.618 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 3.078326e-01 0.512 0 0
Signaling by RAS GAP mutants R-HSA-9753510 3.078326e-01 0.512 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 3.078326e-01 0.512 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.078326e-01 0.512 0 0
Defective F8 cleavage by thrombin R-HSA-9672391 3.078326e-01 0.512 0 0
Defective AHCY causes HMAHCHD R-HSA-5578997 3.078326e-01 0.512 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 2.347259e-01 0.629 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 2.347259e-01 0.629 0 0
TRIF-mediated programmed cell death R-HSA-2562578 2.347259e-01 0.629 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 3.686681e-01 0.433 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 3.686681e-01 0.433 0 0
Axonal growth stimulation R-HSA-209563 3.686681e-01 0.433 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 3.686681e-01 0.433 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 3.686681e-01 0.433 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 3.686681e-01 0.433 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 3.686681e-01 0.433 0 0
MET activates PTPN11 R-HSA-8865999 3.686681e-01 0.433 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 2.685374e-01 0.571 0 0
Formation of annular gap junctions R-HSA-196025 2.685374e-01 0.571 0 0
Lipophagy R-HSA-9613354 3.023194e-01 0.520 0 0
Hypusine synthesis from eIF5A-lysine R-HSA-204626 3.023194e-01 0.520 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 3.023194e-01 0.520 0 0
ALK mutants bind TKIs R-HSA-9700645 3.023194e-01 0.520 0 0
Binding and entry of HIV virion R-HSA-173107 3.358161e-01 0.474 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 3.358161e-01 0.474 0 0
Signaling by Erythropoietin R-HSA-9006335 2.226208e-01 0.652 0 0
FGFR2 alternative splicing R-HSA-6803529 2.585269e-01 0.587 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 3.047452e-01 0.516 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 3.047452e-01 0.516 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 3.047452e-01 0.516 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 3.047452e-01 0.516 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 3.688169e-01 0.433 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 4.011505e-01 0.397 0 0
Activation of RAC1 R-HSA-428540 4.011505e-01 0.397 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 4.011505e-01 0.397 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.011505e-01 0.397 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 2.516946e-01 0.599 0 0
Tight junction interactions R-HSA-420029 3.194146e-01 0.496 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 3.194146e-01 0.496 0 0
HIV Transcription Elongation R-HSA-167169 2.669374e-01 0.574 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 2.669374e-01 0.574 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 2.669374e-01 0.574 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 3.086175e-01 0.511 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 3.792819e-01 0.421 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 2.980604e-01 0.526 0 0
HIV Transcription Initiation R-HSA-167161 2.980604e-01 0.526 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 2.980604e-01 0.526 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 3.606225e-01 0.443 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 4.038268e-01 0.394 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 3.298238e-01 0.482 0 0
RET signaling R-HSA-8853659 3.623074e-01 0.441 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 4.017526e-01 0.396 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 4.017526e-01 0.396 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 3.619818e-01 0.441 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 3.781345e-01 0.422 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 3.781345e-01 0.422 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 3.942983e-01 0.404 0 0
Neutrophil degranulation R-HSA-6798695 2.396705e-01 0.620 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 2.669374e-01 0.574 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 2.669374e-01 0.574 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 3.812253e-01 0.419 0 0
Mitochondrial protein import R-HSA-1268020 3.180096e-01 0.498 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 4.017526e-01 0.396 0 0
Signaling by EGFR R-HSA-177929 2.401947e-01 0.619 0 0
Signaling by ERBB2 R-HSA-1227986 2.914399e-01 0.535 0 0
TGFBR3 expression R-HSA-9839394 3.194146e-01 0.496 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 4.011505e-01 0.397 0 0
Insulin receptor recycling R-HSA-77387 3.812253e-01 0.419 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 4.221532e-01 0.375 0 0
ER-Phagosome pathway R-HSA-1236974 2.952080e-01 0.530 0 0
PI3K/AKT activation R-HSA-198203 3.358161e-01 0.474 0 0
Nuclear RNA decay R-HSA-9930044 2.909525e-01 0.536 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 2.367063e-01 0.626 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.401947e-01 0.619 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 3.619818e-01 0.441 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 3.563153e-01 0.448 0 0
Protein localization R-HSA-9609507 4.068214e-01 0.391 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 3.047452e-01 0.516 0 0
NF-kB is activated and signals survival R-HSA-209560 4.011505e-01 0.397 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 2.585269e-01 0.587 0 0
Germ layer formation at gastrulation R-HSA-9754189 3.792819e-01 0.421 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 3.860235e-01 0.413 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 2.738319e-01 0.563 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 2.738319e-01 0.563 0 0
PTK6 Expression R-HSA-8849473 2.347259e-01 0.629 0 0
Calcineurin activates NFAT R-HSA-2025928 3.023194e-01 0.520 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 3.358161e-01 0.474 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 2.824032e-01 0.549 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 2.824032e-01 0.549 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 2.980604e-01 0.526 0 0
Fanconi Anemia Pathway R-HSA-6783310 3.619818e-01 0.441 0 0
Cellular response to hypoxia R-HSA-1234174 2.340709e-01 0.631 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.952012e-01 0.530 0 0
TBC/RABGAPs R-HSA-8854214 3.298238e-01 0.482 0 0
Developmental Cell Lineages R-HSA-9734767 3.744194e-01 0.427 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 3.298238e-01 0.482 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 2.598914e-01 0.585 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 3.792819e-01 0.421 0 0
Synthesis of DNA R-HSA-69239 3.048162e-01 0.516 0 0
Signal transduction by L1 R-HSA-445144 4.038268e-01 0.394 0 0
Signaling by FGFR2 R-HSA-5654738 4.205229e-01 0.376 0 0
p75NTR signals via NF-kB R-HSA-193639 2.553091e-01 0.593 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 2.116028e-01 0.674 0 0
Mitophagy R-HSA-5205647 3.264265e-01 0.486 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 3.314671e-01 0.480 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 2.411393e-01 0.618 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 3.078326e-01 0.512 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.078326e-01 0.512 0 0
Influenza Virus Induced Apoptosis R-HSA-168277 3.078326e-01 0.512 0 0
Signalling to ERK5 R-HSA-198765 3.078326e-01 0.512 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 3.078326e-01 0.512 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 2.347259e-01 0.629 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 3.023194e-01 0.520 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.553091e-01 0.593 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 2.553091e-01 0.593 0 0
Bicarbonate transporters R-HSA-425381 3.688169e-01 0.433 0 0
vRNP Assembly R-HSA-192905 3.688169e-01 0.433 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 2.220040e-01 0.654 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 2.562307e-01 0.591 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 2.824032e-01 0.549 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 3.619818e-01 0.441 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 3.314671e-01 0.480 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 3.183662e-01 0.497 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 2.401947e-01 0.619 0 0
Biotin transport and metabolism R-HSA-196780 2.553091e-01 0.593 0 0
Pexophagy R-HSA-9664873 3.358161e-01 0.474 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.829859e-01 0.548 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.023194e-01 0.520 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 3.619818e-01 0.441 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 4.076522e-01 0.390 0 0
Metabolism of proteins R-HSA-392499 2.324584e-01 0.634 0 0
Adaptive Immune System R-HSA-1280218 3.968654e-01 0.401 0 0
Intracellular signaling by second messengers R-HSA-9006925 2.265133e-01 0.645 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 2.347259e-01 0.629 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.023194e-01 0.520 0 0
Signaling by Activin R-HSA-1502540 2.553091e-01 0.593 0 0
LGI-ADAM interactions R-HSA-5682910 3.688169e-01 0.433 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 2.980604e-01 0.526 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 2.980604e-01 0.526 0 0
Hedgehog ligand biogenesis R-HSA-5358346 3.022538e-01 0.520 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 3.022538e-01 0.520 0 0
Integration of energy metabolism R-HSA-163685 2.494934e-01 0.603 0 0
Regulation of KIT signaling R-HSA-1433559 2.310196e-01 0.636 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 2.387467e-01 0.622 0 0
Neuronal System R-HSA-112316 3.435734e-01 0.464 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 2.347259e-01 0.629 0 0
Intracellular oxygen transport R-HSA-8981607 3.686681e-01 0.433 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 3.023194e-01 0.520 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.023194e-01 0.520 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 3.023194e-01 0.520 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 3.688169e-01 0.433 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 2.669374e-01 0.574 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 2.669374e-01 0.574 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 3.443370e-01 0.463 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 3.443370e-01 0.463 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 3.739798e-01 0.427 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 4.161896e-01 0.381 0 0
Transmission across Chemical Synapses R-HSA-112315 2.339131e-01 0.631 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 3.358161e-01 0.474 0 0
Interleukin-37 signaling R-HSA-9008059 2.392640e-01 0.621 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 2.516946e-01 0.599 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 2.516946e-01 0.599 0 0
Inflammasomes R-HSA-622312 3.812253e-01 0.419 0 0
Degradation of DVL R-HSA-4641258 3.802981e-01 0.420 0 0
Hedgehog 'on' state R-HSA-5632684 3.059003e-01 0.514 1 1
NGF-stimulated transcription R-HSA-9031628 4.104461e-01 0.387 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 3.358161e-01 0.474 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.387467e-01 0.622 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 3.606225e-01 0.443 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 3.623074e-01 0.441 0 0
Degradation of AXIN R-HSA-4641257 3.802981e-01 0.420 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 3.606225e-01 0.443 0 0
Response of Mtb to phagocytosis R-HSA-9637690 3.298238e-01 0.482 0 0
Zinc transporters R-HSA-435354 2.310196e-01 0.636 0 0
G1/S-Specific Transcription R-HSA-69205 3.623074e-01 0.441 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 2.347259e-01 0.629 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.023194e-01 0.520 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 4.011505e-01 0.397 0 0
Vpu mediated degradation of CD4 R-HSA-180534 3.086175e-01 0.511 0 0
Regulation of Apoptosis R-HSA-169911 3.443370e-01 0.463 0 0
Interleukin-1 family signaling R-HSA-446652 2.270856e-01 0.644 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 3.619818e-01 0.441 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 3.619818e-01 0.441 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 3.082123e-01 0.511 0 0
Tandem pore domain potassium channels R-HSA-1296346 3.358161e-01 0.474 0 0
Selenoamino acid metabolism R-HSA-2408522 3.208282e-01 0.494 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 4.049701e-01 0.393 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 3.296477e-01 0.482 0 0
XBP1(S) activates chaperone genes R-HSA-381038 2.629131e-01 0.580 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 2.310196e-01 0.636 0 0
IRE1alpha activates chaperones R-HSA-381070 3.285066e-01 0.483 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 3.792819e-01 0.421 0 0
Unfolded Protein Response (UPR) R-HSA-381119 2.741291e-01 0.562 0 0
Regulation of gene expression in beta cells R-HSA-210745 4.017526e-01 0.396 0 0
HCN channels R-HSA-1296061 4.241600e-01 0.372 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 4.241600e-01 0.372 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 4.241600e-01 0.372 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 4.241600e-01 0.372 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 4.241600e-01 0.372 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.241600e-01 0.372 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 4.241600e-01 0.372 0 0
Regulation of gap junction activity R-HSA-191650 4.241600e-01 0.372 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 4.241600e-01 0.372 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 4.241600e-01 0.372 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 4.241600e-01 0.372 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 4.241600e-01 0.372 0 0
TNFR1-mediated ceramide production R-HSA-5626978 4.241600e-01 0.372 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 4.272112e-01 0.369 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 4.280813e-01 0.368 0 0
Post-translational protein modification R-HSA-597592 4.285751e-01 0.368 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 4.326792e-01 0.364 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 4.326792e-01 0.364 0 0
GRB2 events in EGFR signaling R-HSA-179812 4.326792e-01 0.364 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 4.326792e-01 0.364 0 0
p75NTR recruits signalling complexes R-HSA-209543 4.326792e-01 0.364 0 0
Signaling by LTK R-HSA-9842663 4.326792e-01 0.364 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 4.326792e-01 0.364 0 0
Diseases of Immune System R-HSA-5260271 4.340196e-01 0.362 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 4.340196e-01 0.362 0 0
EGFR downregulation R-HSA-182971 4.423794e-01 0.354 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 4.492054e-01 0.348 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 4.519751e-01 0.345 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 4.519751e-01 0.345 0 0
Ribavirin ADME R-HSA-9755088 4.519751e-01 0.345 0 0
Serine metabolism R-HSA-977347 4.519751e-01 0.345 0 0
Mitochondrial calcium ion transport R-HSA-8949215 4.519751e-01 0.345 0 0
Assembly Of The HIV Virion R-HSA-175474 4.519751e-01 0.345 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 4.545484e-01 0.342 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 4.545484e-01 0.342 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 4.585359e-01 0.339 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 4.593897e-01 0.338 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 4.623876e-01 0.335 0 0
Signaling by WNT in cancer R-HSA-4791275 4.623876e-01 0.335 0 0
G0 and Early G1 R-HSA-1538133 4.623876e-01 0.335 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 4.632949e-01 0.334 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 4.632949e-01 0.334 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 4.632949e-01 0.334 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 4.632949e-01 0.334 0 0
Interleukin-6 signaling R-HSA-1059683 4.632949e-01 0.334 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 4.632949e-01 0.334 0 0
Signaling by PDGF R-HSA-186797 4.638299e-01 0.334 0 0
Inositol phosphate metabolism R-HSA-1483249 4.690698e-01 0.329 0 0
Signaling by FGFR1 in disease R-HSA-5655302 4.692859e-01 0.329 0 0
Degradation of CRY and PER proteins R-HSA-9932298 4.692859e-01 0.329 0 0
Signaling by TGFB family members R-HSA-9006936 4.709725e-01 0.327 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 4.743682e-01 0.324 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 4.743682e-01 0.324 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 4.747774e-01 0.324 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 4.747774e-01 0.324 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 4.747774e-01 0.324 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 4.747774e-01 0.324 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 4.747774e-01 0.324 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 4.747774e-01 0.324 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 4.747774e-01 0.324 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 4.747774e-01 0.324 0 0
Suppression of autophagy R-HSA-9636569 4.747774e-01 0.324 0 0
Muscarinic acetylcholine receptors R-HSA-390648 4.747774e-01 0.324 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 4.747774e-01 0.324 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 4.747774e-01 0.324 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 4.747774e-01 0.324 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 4.747774e-01 0.324 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 4.747774e-01 0.324 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 4.747774e-01 0.324 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 4.747774e-01 0.324 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 4.754462e-01 0.323 0 0
Notch-HLH transcription pathway R-HSA-350054 4.754462e-01 0.323 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 4.754462e-01 0.323 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 4.765565e-01 0.322 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 4.821378e-01 0.317 0 0
Integrin signaling R-HSA-354192 4.821378e-01 0.317 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 4.821378e-01 0.317 0 0
FGFR1 mutant receptor activation R-HSA-1839124 4.821378e-01 0.317 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 4.821378e-01 0.317 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 4.844251e-01 0.315 0 0
Mitochondrial protein degradation R-HSA-9837999 4.868365e-01 0.313 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 4.900649e-01 0.310 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 4.900649e-01 0.310 0 0
Amino acids regulate mTORC1 R-HSA-9639288 4.900649e-01 0.310 0 0
Regulation of PTEN stability and activity R-HSA-8948751 4.900649e-01 0.310 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 4.929145e-01 0.307 0 0
Beta oxidation of hexanoyl-CoA to butanoyl-CoA R-HSA-77350 4.929145e-01 0.307 0 0
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA R-HSA-77310 4.929145e-01 0.307 0 0
Beta oxidation of octanoyl-CoA to hexanoyl-CoA R-HSA-77348 4.929145e-01 0.307 0 0
NRIF signals cell death from the nucleus R-HSA-205043 4.929145e-01 0.307 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 4.929145e-01 0.307 0 0
Malate-aspartate shuttle R-HSA-9856872 4.929145e-01 0.307 0 0
Acyl chain remodeling of CL R-HSA-1482798 4.929145e-01 0.307 0 0
Circadian clock R-HSA-9909396 4.941897e-01 0.306 0 0
Syndecan interactions R-HSA-3000170 4.984412e-01 0.302 0 0
Growth hormone receptor signaling R-HSA-982772 4.984412e-01 0.302 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 5.015937e-01 0.300 0 0
Signaling by FGFR4 R-HSA-5654743 5.038346e-01 0.298 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 5.038346e-01 0.298 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 5.056059e-01 0.296 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 5.124788e-01 0.290 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 5.207227e-01 0.283 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 5.207227e-01 0.283 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 5.207227e-01 0.283 0 0
Amine ligand-binding receptors R-HSA-375280 5.207754e-01 0.283 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 5.207754e-01 0.283 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 5.209141e-01 0.283 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 5.209141e-01 0.283 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 5.209141e-01 0.283 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 5.209481e-01 0.283 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 5.209481e-01 0.283 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 5.209481e-01 0.283 0 0
Plus-strand DNA synthesis R-HSA-164525 5.209481e-01 0.283 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 5.209481e-01 0.283 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.209481e-01 0.283 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 5.209481e-01 0.283 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.209481e-01 0.283 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 5.209481e-01 0.283 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.209481e-01 0.283 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 5.209481e-01 0.283 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 5.209481e-01 0.283 0 0
VEGF ligand-receptor interactions R-HSA-194313 5.209481e-01 0.283 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 5.209481e-01 0.283 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 5.209481e-01 0.283 0 0
TRAIL signaling R-HSA-75158 5.209481e-01 0.283 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 5.209721e-01 0.283 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 5.214765e-01 0.283 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 5.214765e-01 0.283 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 5.214765e-01 0.283 0 0
SHC1 events in EGFR signaling R-HSA-180336 5.214765e-01 0.283 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 5.214765e-01 0.283 0 0
G beta:gamma signalling through BTK R-HSA-8964315 5.214765e-01 0.283 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 5.214765e-01 0.283 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 5.214765e-01 0.283 0 0
PCP/CE pathway R-HSA-4086400 5.346746e-01 0.272 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 5.361462e-01 0.271 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 5.361462e-01 0.271 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 5.374635e-01 0.270 0 0
Signaling by FGFR3 R-HSA-5654741 5.374635e-01 0.270 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 5.394960e-01 0.268 0 0
PERK regulates gene expression R-HSA-381042 5.394960e-01 0.268 0 0
G protein gated Potassium channels R-HSA-1296059 5.428262e-01 0.265 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 5.428262e-01 0.265 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 5.428262e-01 0.265 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 5.428262e-01 0.265 0 0
HDMs demethylate histones R-HSA-3214842 5.428262e-01 0.265 0 0
Formation of the nephric duct R-HSA-9830364 5.428262e-01 0.265 0 0
Interleukin-7 signaling R-HSA-1266695 5.428262e-01 0.265 0 0
Antigen processing-Cross presentation R-HSA-1236975 5.449171e-01 0.264 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 5.449171e-01 0.264 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 5.456009e-01 0.263 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 5.456009e-01 0.263 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 5.456009e-01 0.263 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 5.489382e-01 0.260 0 0
Attachment and Entry R-HSA-9678110 5.489382e-01 0.260 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 5.489382e-01 0.260 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 5.489382e-01 0.260 0 0
Phase 4 - resting membrane potential R-HSA-5576886 5.489382e-01 0.260 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 5.489382e-01 0.260 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 5.489382e-01 0.260 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 5.511118e-01 0.259 0 0
Regulation of pyruvate metabolism R-HSA-9861718 5.538787e-01 0.257 0 0
Signaling by TGFBR3 R-HSA-9839373 5.538787e-01 0.257 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 5.548586e-01 0.256 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 5.558517e-01 0.255 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 5.578879e-01 0.253 0 0
RNA Polymerase III Transcription R-HSA-74158 5.578879e-01 0.253 0 0
GPVI-mediated activation cascade R-HSA-114604 5.578879e-01 0.253 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 5.630626e-01 0.249 0 0
Signaling by LTK in cancer R-HSA-9842640 5.630626e-01 0.249 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 5.630626e-01 0.249 0 0
STAT5 Activation R-HSA-9645135 5.630626e-01 0.249 0 0
Erythropoietin activates STAT5 R-HSA-9027283 5.630626e-01 0.249 0 0
Uncoating of the HIV Virion R-HSA-162585 5.630626e-01 0.249 0 0
Abacavir transmembrane transport R-HSA-2161517 5.630626e-01 0.249 0 0
Defective factor VIII causes hemophilia A R-HSA-9662001 5.630626e-01 0.249 0 0
Chylomicron clearance R-HSA-8964026 5.630626e-01 0.249 0 0
VLDL assembly R-HSA-8866423 5.630626e-01 0.249 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 5.641455e-01 0.249 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 5.641455e-01 0.249 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 5.641455e-01 0.249 0 0
TRP channels R-HSA-3295583 5.641455e-01 0.249 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 5.641455e-01 0.249 0 0
Metalloprotease DUBs R-HSA-5689901 5.641455e-01 0.249 0 0
TCR signaling R-HSA-202403 5.666848e-01 0.247 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 5.700030e-01 0.244 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 5.752722e-01 0.240 0 0
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA R-HSA-77346 5.752722e-01 0.240 0 0
Disorders of Developmental Biology R-HSA-9675151 5.752722e-01 0.240 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 5.752722e-01 0.240 0 0
Response to metal ions R-HSA-5660526 5.752722e-01 0.240 0 0
Ovarian tumor domain proteases R-HSA-5689896 5.758762e-01 0.240 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 5.796297e-01 0.237 0 0
Regulation of beta-cell development R-HSA-186712 5.803591e-01 0.236 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 5.848460e-01 0.233 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 5.848460e-01 0.233 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 5.848460e-01 0.233 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 5.914093e-01 0.228 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 5.934417e-01 0.227 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 5.934417e-01 0.227 0 0
Metabolism of polyamines R-HSA-351202 5.946147e-01 0.226 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 5.985122e-01 0.223 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 6.004645e-01 0.222 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 6.004645e-01 0.222 0 0
Specification of primordial germ cells R-HSA-9827857 6.004645e-01 0.222 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 6.014770e-01 0.221 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 6.014770e-01 0.221 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 6.014770e-01 0.221 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.014770e-01 0.221 0 0
Recycling of eIF2:GDP R-HSA-72731 6.014770e-01 0.221 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 6.014770e-01 0.221 0 0
Disinhibition of SNARE formation R-HSA-114516 6.014770e-01 0.221 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 6.014770e-01 0.221 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 6.014770e-01 0.221 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.014770e-01 0.221 0 0
LDL remodeling R-HSA-8964041 6.014770e-01 0.221 0 0
Netrin mediated repulsion signals R-HSA-418886 6.014770e-01 0.221 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 6.014770e-01 0.221 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 6.014770e-01 0.221 0 0
CHL1 interactions R-HSA-447041 6.014770e-01 0.221 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 6.014770e-01 0.221 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 6.049075e-01 0.218 0 0
Formation of the Early Elongation Complex R-HSA-113418 6.049075e-01 0.218 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 6.049075e-01 0.218 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 6.099205e-01 0.215 0 0
Pentose phosphate pathway R-HSA-71336 6.105683e-01 0.214 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 6.105683e-01 0.214 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 6.124930e-01 0.213 0 0
Extracellular matrix organization R-HSA-1474244 6.145537e-01 0.211 0 0
Azathioprine ADME R-HSA-9748787 6.164764e-01 0.210 0 0
NCAM signaling for neurite out-growth R-HSA-375165 6.223341e-01 0.206 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 6.223341e-01 0.206 0 0
Heme signaling R-HSA-9707616 6.223341e-01 0.206 0 0
DARPP-32 events R-HSA-180024 6.243151e-01 0.205 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 6.245123e-01 0.204 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 6.245123e-01 0.204 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 6.245123e-01 0.204 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 6.245123e-01 0.204 0 0
Presynaptic function of Kainate receptors R-HSA-500657 6.245123e-01 0.204 0 0
Tie2 Signaling R-HSA-210993 6.245123e-01 0.204 0 0
Nephron development R-HSA-9831926 6.245123e-01 0.204 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 6.245123e-01 0.204 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 6.272427e-01 0.203 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 6.292154e-01 0.201 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 6.335595e-01 0.198 0 0
Reverse Transcription of HIV RNA R-HSA-162589 6.365162e-01 0.196 0 0
Minus-strand DNA synthesis R-HSA-164516 6.365162e-01 0.196 0 0
phospho-PLA2 pathway R-HSA-111995 6.365162e-01 0.196 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 6.365162e-01 0.196 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 6.365162e-01 0.196 0 0
MET receptor recycling R-HSA-8875656 6.365162e-01 0.196 0 0
Regulation by c-FLIP R-HSA-3371378 6.365162e-01 0.196 0 0
Activation of RAS in B cells R-HSA-1169092 6.365162e-01 0.196 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 6.365162e-01 0.196 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 6.365162e-01 0.196 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 6.365162e-01 0.196 0 0
Dimerization of procaspase-8 R-HSA-69416 6.365162e-01 0.196 0 0
TGFBR3 PTM regulation R-HSA-9839383 6.365162e-01 0.196 0 0
SLC-mediated bile acid transport R-HSA-9958517 6.365162e-01 0.196 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 6.365162e-01 0.196 0 0
Interleukin-23 signaling R-HSA-9020933 6.365162e-01 0.196 0 0
DAP12 signaling R-HSA-2424491 6.430584e-01 0.192 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 6.430584e-01 0.192 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 6.430584e-01 0.192 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 6.430584e-01 0.192 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 6.434543e-01 0.191 0 0
Neurexins and neuroligins R-HSA-6794361 6.457544e-01 0.190 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 6.457544e-01 0.190 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 6.474222e-01 0.189 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 6.474222e-01 0.189 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 6.474222e-01 0.189 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 6.474222e-01 0.189 0 0
Other interleukin signaling R-HSA-449836 6.474222e-01 0.189 0 0
STING mediated induction of host immune responses R-HSA-1834941 6.474222e-01 0.189 0 0
Pyruvate metabolism R-HSA-70268 6.563839e-01 0.183 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 6.644438e-01 0.178 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 6.684765e-01 0.175 0 0
CASP8 activity is inhibited R-HSA-5218900 6.684765e-01 0.175 0 0
p75NTR regulates axonogenesis R-HSA-193697 6.684765e-01 0.175 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 6.684765e-01 0.175 0 0
Regulation of signaling by NODAL R-HSA-1433617 6.684765e-01 0.175 0 0
MAPK1 (ERK2) activation R-HSA-112411 6.684765e-01 0.175 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 6.684765e-01 0.175 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 6.684765e-01 0.175 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 6.684765e-01 0.175 0 0
Interleukin-1 processing R-HSA-448706 6.684765e-01 0.175 0 0
Regulated proteolysis of p75NTR R-HSA-193692 6.684765e-01 0.175 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 6.684765e-01 0.175 0 0
Co-inhibition by CTLA4 R-HSA-389513 6.692082e-01 0.174 0 0
Negative regulation of MET activity R-HSA-6807004 6.692082e-01 0.174 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 6.692082e-01 0.174 0 0
Signaling by FGFR R-HSA-190236 6.707341e-01 0.173 0 0
Gastrulation R-HSA-9758941 6.713793e-01 0.173 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 6.744582e-01 0.171 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 6.775533e-01 0.169 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 6.775533e-01 0.169 0 0
Diseases of mitotic cell cycle R-HSA-9675126 6.785315e-01 0.168 0 0
Inwardly rectifying K+ channels R-HSA-1296065 6.785315e-01 0.168 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 6.785315e-01 0.168 0 0
FOXO-mediated transcription R-HSA-9614085 6.809694e-01 0.167 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 6.810150e-01 0.167 0 0
Signaling by NOTCH3 R-HSA-9012852 6.869470e-01 0.163 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 6.898909e-01 0.161 0 0
G-protein activation R-HSA-202040 6.898909e-01 0.161 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 6.898909e-01 0.161 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 6.898909e-01 0.161 0 0
ERK/MAPK targets R-HSA-198753 6.898909e-01 0.161 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 6.898909e-01 0.161 0 0
ABC-family proteins mediated transport R-HSA-382556 6.910089e-01 0.161 0 0
G-protein beta:gamma signalling R-HSA-397795 6.952602e-01 0.158 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 6.952602e-01 0.158 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 6.976284e-01 0.156 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 6.976284e-01 0.156 0 0
Formation of apoptosome R-HSA-111458 6.976284e-01 0.156 0 0
Regulation of the apoptosome activity R-HSA-9627069 6.976284e-01 0.156 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 6.976284e-01 0.156 0 0
MAPK3 (ERK1) activation R-HSA-110056 6.976284e-01 0.156 0 0
Josephin domain DUBs R-HSA-5689877 6.976284e-01 0.156 0 0
Adipogenesis R-HSA-9843745 6.984496e-01 0.156 0 0
Signaling by MET R-HSA-6806834 6.985838e-01 0.156 0 0
TNF signaling R-HSA-75893 6.999313e-01 0.155 0 0
Signaling by FGFR1 R-HSA-5654736 6.999313e-01 0.155 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 7.047040e-01 0.152 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 7.047040e-01 0.152 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 7.094959e-01 0.149 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 7.094959e-01 0.149 0 0
Attachment and Entry R-HSA-9694614 7.094959e-01 0.149 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 7.094959e-01 0.149 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 7.094959e-01 0.149 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 7.102295e-01 0.149 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 7.113214e-01 0.148 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 7.134304e-01 0.147 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 7.173591e-01 0.144 0 0
Signaling by Insulin receptor R-HSA-74752 7.196095e-01 0.143 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 7.242184e-01 0.140 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 7.242184e-01 0.140 0 0
vRNA Synthesis R-HSA-192814 7.242184e-01 0.140 0 0
Chylomicron assembly R-HSA-8963888 7.242184e-01 0.140 0 0
Propionyl-CoA catabolism R-HSA-71032 7.242184e-01 0.140 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 7.242184e-01 0.140 0 0
Transport of RCbl within the body R-HSA-9758890 7.242184e-01 0.140 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.242184e-01 0.140 0 0
Prostanoid ligand receptors R-HSA-391908 7.242184e-01 0.140 0 0
Interleukin-2 signaling R-HSA-9020558 7.242184e-01 0.140 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.242184e-01 0.140 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 7.247660e-01 0.140 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 7.267220e-01 0.139 0 0
eNOS activation R-HSA-203615 7.267220e-01 0.139 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 7.267220e-01 0.139 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 7.267220e-01 0.139 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 7.280526e-01 0.138 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 7.280526e-01 0.138 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 7.280526e-01 0.138 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 7.280526e-01 0.138 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 7.280526e-01 0.138 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 7.280526e-01 0.138 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 7.280526e-01 0.138 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.280526e-01 0.138 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.303685e-01 0.136 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 7.303685e-01 0.136 0 0
Regulation of TNFR1 signaling R-HSA-5357905 7.306961e-01 0.136 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 7.306961e-01 0.136 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 7.306961e-01 0.136 0 0
Diseases of DNA repair R-HSA-9675135 7.306961e-01 0.136 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 7.325853e-01 0.135 0 0
Regulation of mitotic cell cycle R-HSA-453276 7.325853e-01 0.135 0 0
Toll-like Receptor Cascades R-HSA-168898 7.331923e-01 0.135 0 0
Oncogene Induced Senescence R-HSA-2559585 7.414710e-01 0.130 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 7.418004e-01 0.130 0 0
Asparagine N-linked glycosylation R-HSA-446203 7.454891e-01 0.128 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 7.455938e-01 0.127 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 7.455938e-01 0.127 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 7.455938e-01 0.127 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 7.455938e-01 0.127 0 0
Interleukin receptor SHC signaling R-HSA-912526 7.455938e-01 0.127 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 7.455938e-01 0.127 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 7.471617e-01 0.127 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 7.484716e-01 0.126 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 7.484716e-01 0.126 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 7.484716e-01 0.126 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 7.484716e-01 0.126 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 7.484716e-01 0.126 0 0
Plasmalogen biosynthesis R-HSA-75896 7.484716e-01 0.126 0 0
ERKs are inactivated R-HSA-202670 7.484716e-01 0.126 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 7.484716e-01 0.126 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 7.484716e-01 0.126 0 0
tRNA processing R-HSA-72306 7.501896e-01 0.125 0 0
Co-stimulation by CD28 R-HSA-389356 7.559418e-01 0.122 0 0
Metal ion SLC transporters R-HSA-425410 7.559418e-01 0.122 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 7.621546e-01 0.118 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 7.621546e-01 0.118 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 7.621546e-01 0.118 0 0
Interleukin-6 family signaling R-HSA-6783589 7.621546e-01 0.118 0 0
Signaling by FGFR in disease R-HSA-1226099 7.637791e-01 0.117 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 7.659925e-01 0.116 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 7.678608e-01 0.115 0 0
Metabolism of folate and pterines R-HSA-196757 7.690604e-01 0.114 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 7.705932e-01 0.113 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 7.705932e-01 0.113 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 7.705932e-01 0.113 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 7.705932e-01 0.113 0 0
Beta oxidation of myristoyl-CoA to lauroyl-CoA R-HSA-77285 7.705932e-01 0.113 0 0
Beta oxidation of palmitoyl-CoA to myristoyl-CoA R-HSA-77305 7.705932e-01 0.113 0 0
Repression of WNT target genes R-HSA-4641265 7.705932e-01 0.113 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 7.705932e-01 0.113 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 7.705932e-01 0.113 0 0
MET activates RAS signaling R-HSA-8851805 7.705932e-01 0.113 0 0
Polymerase switching R-HSA-69091 7.705932e-01 0.113 0 0
Leading Strand Synthesis R-HSA-69109 7.705932e-01 0.113 0 0
Disorders of Nervous System Development R-HSA-9697154 7.705932e-01 0.113 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 7.705932e-01 0.113 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 7.705932e-01 0.113 0 0
Pervasive developmental disorders R-HSA-9005895 7.705932e-01 0.113 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 7.705932e-01 0.113 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 7.705932e-01 0.113 0 0
OAS antiviral response R-HSA-8983711 7.705932e-01 0.113 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.777717e-01 0.109 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 7.777717e-01 0.109 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 7.777717e-01 0.109 0 0
MET promotes cell motility R-HSA-8875878 7.819278e-01 0.107 0 0
Regulation of insulin secretion R-HSA-422356 7.829212e-01 0.106 0 0
Signaling by NOTCH1 R-HSA-1980143 7.830291e-01 0.106 0 0
Insulin receptor signalling cascade R-HSA-74751 7.902648e-01 0.102 0 0
CD28 dependent Vav1 pathway R-HSA-389359 7.907705e-01 0.102 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 7.907705e-01 0.102 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 7.907705e-01 0.102 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 7.907705e-01 0.102 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 7.907705e-01 0.102 0 0
Processing of SMDT1 R-HSA-8949664 7.907705e-01 0.102 0 0
Disease R-HSA-1643685 7.918942e-01 0.101 0 0
Translation of Structural Proteins R-HSA-9694635 7.921975e-01 0.101 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 7.924829e-01 0.101 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 7.924829e-01 0.101 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 7.924829e-01 0.101 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 7.924829e-01 0.101 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 7.941972e-01 0.100 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.008857e-01 0.096 0 0
ABC transporter disorders R-HSA-5619084 8.010661e-01 0.096 0 0
Immune System R-HSA-168256 8.015329e-01 0.096 0 0
SLC transporter disorders R-HSA-5619102 8.016034e-01 0.096 0 0
Downstream TCR signaling R-HSA-202424 8.034648e-01 0.095 0 0
Generation of second messenger molecules R-HSA-202433 8.058850e-01 0.094 0 0
Interleukin-2 family signaling R-HSA-451927 8.058850e-01 0.094 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 8.063268e-01 0.093 0 0
Cristae formation R-HSA-8949613 8.063268e-01 0.093 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 8.063268e-01 0.093 0 0
Removal of the Flap Intermediate R-HSA-69166 8.091741e-01 0.092 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 8.091741e-01 0.092 0 0
Hydrolysis of LPC R-HSA-1483115 8.091741e-01 0.092 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 8.091741e-01 0.092 0 0
Prolactin receptor signaling R-HSA-1170546 8.091741e-01 0.092 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.091741e-01 0.092 0 0
Signaling by FGFR4 in disease R-HSA-5655291 8.091741e-01 0.092 0 0
Formation of the cornified envelope R-HSA-6809371 8.140112e-01 0.089 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 8.170085e-01 0.088 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 8.170085e-01 0.088 0 0
FLT3 Signaling R-HSA-9607240 8.170085e-01 0.088 0 0
Kidney development R-HSA-9830369 8.181217e-01 0.087 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.193420e-01 0.087 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 8.259133e-01 0.083 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.259600e-01 0.083 0 0
Processive synthesis on the lagging strand R-HSA-69183 8.259600e-01 0.083 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 8.259600e-01 0.083 0 0
p38MAPK events R-HSA-171007 8.259600e-01 0.083 0 0
Beta oxidation of butanoyl-CoA to acetyl-CoA R-HSA-77352 8.259600e-01 0.083 0 0
Protein lipoylation R-HSA-9857492 8.259600e-01 0.083 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 8.259600e-01 0.083 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 8.259600e-01 0.083 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.259600e-01 0.083 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.259600e-01 0.083 0 0
DNA Damage Reversal R-HSA-73942 8.259600e-01 0.083 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 8.266113e-01 0.083 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.275853e-01 0.082 0 0
Translation of Structural Proteins R-HSA-9683701 8.275853e-01 0.082 0 0
G alpha (z) signalling events R-HSA-418597 8.299995e-01 0.081 0 0
mRNA Capping R-HSA-72086 8.315672e-01 0.080 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 8.315672e-01 0.080 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 8.315672e-01 0.080 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 8.315672e-01 0.080 0 0
Glucagon-type ligand receptors R-HSA-420092 8.315672e-01 0.080 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 8.361642e-01 0.078 0 0
Interferon alpha/beta signaling R-HSA-909733 8.369342e-01 0.077 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 8.376339e-01 0.077 0 0
Activation of GABAB receptors R-HSA-991365 8.376339e-01 0.077 0 0
GABA B receptor activation R-HSA-977444 8.376339e-01 0.077 0 0
Ca-dependent events R-HSA-111996 8.376339e-01 0.077 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 8.408142e-01 0.075 0 0
Phosphorylation of the APC/C R-HSA-176412 8.412702e-01 0.075 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.412702e-01 0.075 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.412702e-01 0.075 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 8.412702e-01 0.075 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 8.412702e-01 0.075 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 8.412702e-01 0.075 0 0
Negative regulation of FLT3 R-HSA-9706369 8.412702e-01 0.075 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 8.412702e-01 0.075 0 0
Activation of SMO R-HSA-5635838 8.412702e-01 0.075 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 8.412702e-01 0.075 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 8.412702e-01 0.075 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 8.412702e-01 0.075 0 0
Atorvastatin ADME R-HSA-9754706 8.412702e-01 0.075 0 0
Virus Assembly and Release R-HSA-168268 8.412702e-01 0.075 0 0
Nucleotide Excision Repair R-HSA-5696398 8.416243e-01 0.075 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 8.429235e-01 0.074 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.430406e-01 0.074 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 8.430406e-01 0.074 0 0
Neurotransmitter clearance R-HSA-112311 8.430406e-01 0.074 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.430406e-01 0.074 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.430406e-01 0.074 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 8.430406e-01 0.074 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 8.457984e-01 0.073 0 0
IRS-mediated signalling R-HSA-112399 8.473721e-01 0.072 0 0
Platelet homeostasis R-HSA-418346 8.479898e-01 0.072 0 0
Disorders of transmembrane transporters R-HSA-5619115 8.491265e-01 0.071 0 0
Rab regulation of trafficking R-HSA-9007101 8.491652e-01 0.071 0 0
Leishmania phagocytosis R-HSA-9664417 8.529074e-01 0.069 0 0
Parasite infection R-HSA-9664407 8.529074e-01 0.069 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 8.529074e-01 0.069 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.537998e-01 0.069 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 8.537998e-01 0.069 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 8.552344e-01 0.068 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 8.552344e-01 0.068 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 8.552344e-01 0.068 0 0
Heme assimilation R-HSA-9927020 8.552344e-01 0.068 0 0
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids R-HSA-77288 8.552344e-01 0.068 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 8.552344e-01 0.068 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 8.552344e-01 0.068 0 0
Passive transport by Aquaporins R-HSA-432047 8.552344e-01 0.068 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 8.552344e-01 0.068 0 0
Coenzyme A biosynthesis R-HSA-196783 8.552344e-01 0.068 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 8.552344e-01 0.068 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 8.552344e-01 0.068 0 0
DAP12 interactions R-HSA-2172127 8.562203e-01 0.067 0 0
Potassium Channels R-HSA-1296071 8.603575e-01 0.065 0 0
Peroxisomal protein import R-HSA-9033241 8.632203e-01 0.064 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 8.632203e-01 0.064 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 8.647957e-01 0.063 0 0
Ca2+ pathway R-HSA-4086398 8.648687e-01 0.063 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 8.679709e-01 0.061 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 8.679709e-01 0.061 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 8.679709e-01 0.061 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 8.679709e-01 0.061 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 8.679709e-01 0.061 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 8.679709e-01 0.061 0 0
Choline catabolism R-HSA-6798163 8.679709e-01 0.061 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 8.679709e-01 0.061 0 0
Uptake and function of anthrax toxins R-HSA-5210891 8.679709e-01 0.061 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 8.679709e-01 0.061 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 8.706019e-01 0.060 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 8.706019e-01 0.060 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 8.706019e-01 0.060 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 8.706019e-01 0.060 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 8.706019e-01 0.060 0 0
tRNA Aminoacylation R-HSA-379724 8.706019e-01 0.060 0 0
Post-translational protein phosphorylation R-HSA-8957275 8.722653e-01 0.059 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 8.776376e-01 0.057 0 0
Aquaporin-mediated transport R-HSA-445717 8.776376e-01 0.057 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 8.795875e-01 0.056 0 0
PKA activation R-HSA-163615 8.795875e-01 0.056 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 8.795875e-01 0.056 0 0
PKA activation in glucagon signalling R-HSA-164378 8.795875e-01 0.056 0 0
Apoptotic factor-mediated response R-HSA-111471 8.795875e-01 0.056 0 0
Polo-like kinase mediated events R-HSA-156711 8.795875e-01 0.056 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 8.795875e-01 0.056 0 0
Mismatch Repair R-HSA-5358508 8.795875e-01 0.056 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 8.795875e-01 0.056 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.821559e-01 0.054 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 8.821559e-01 0.054 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 8.843393e-01 0.053 0 0
GPER1 signaling R-HSA-9634597 8.878743e-01 0.052 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 8.901827e-01 0.051 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 8.901827e-01 0.051 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 8.901827e-01 0.051 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 8.901827e-01 0.051 0 0
Specification of the neural plate border R-HSA-9834899 8.901827e-01 0.051 0 0
Diseases of hemostasis R-HSA-9671793 8.901827e-01 0.051 0 0
Translesion Synthesis by POLH R-HSA-110320 8.901827e-01 0.051 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 8.901827e-01 0.051 0 0
E2F mediated regulation of DNA replication R-HSA-113510 8.901827e-01 0.051 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 8.901827e-01 0.051 0 0
Dual Incision in GG-NER R-HSA-5696400 8.904166e-01 0.050 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 8.904166e-01 0.050 0 0
DNA Damage Bypass R-HSA-73893 8.947458e-01 0.048 0 0
Chemokine receptors bind chemokines R-HSA-380108 8.947458e-01 0.048 0 0
Integrin cell surface interactions R-HSA-216083 8.956911e-01 0.048 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 8.964881e-01 0.047 0 0
IGF1R signaling cascade R-HSA-2428924 8.967882e-01 0.047 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 8.967882e-01 0.047 0 0
Acyl chain remodelling of PE R-HSA-1482839 8.981367e-01 0.047 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 8.981367e-01 0.047 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 8.981367e-01 0.047 0 0
Transferrin endocytosis and recycling R-HSA-917977 8.981367e-01 0.047 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 8.981367e-01 0.047 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 8.998461e-01 0.046 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 8.998461e-01 0.046 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 8.998461e-01 0.046 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 8.998461e-01 0.046 0 0
Creatine metabolism R-HSA-71288 8.998461e-01 0.046 0 0
Acyl chain remodelling of PI R-HSA-1482922 8.998461e-01 0.046 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 8.998461e-01 0.046 0 0
Protein hydroxylation R-HSA-9629569 8.998461e-01 0.046 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 8.998461e-01 0.046 0 0
PI3K Cascade R-HSA-109704 9.012365e-01 0.045 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 9.025587e-01 0.045 0 0
Opioid Signalling R-HSA-111885 9.030410e-01 0.044 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.053473e-01 0.043 0 0
Calmodulin induced events R-HSA-111933 9.053473e-01 0.043 0 0
CaM pathway R-HSA-111997 9.053473e-01 0.043 0 0
Glycosphingolipid transport R-HSA-9845576 9.053473e-01 0.043 0 0
Triglyceride catabolism R-HSA-163560 9.053473e-01 0.043 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.053473e-01 0.043 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 9.086598e-01 0.042 0 0
Lagging Strand Synthesis R-HSA-69186 9.086598e-01 0.042 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 9.086598e-01 0.042 0 0
Signalling to RAS R-HSA-167044 9.086598e-01 0.042 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.086598e-01 0.042 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.086598e-01 0.042 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.086598e-01 0.042 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.086598e-01 0.042 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.086598e-01 0.042 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.086598e-01 0.042 0 0
Mitochondrial biogenesis R-HSA-1592230 9.134571e-01 0.039 0 0
Peptide hormone metabolism R-HSA-2980736 9.134571e-01 0.039 0 0
Collagen formation R-HSA-1474290 9.152479e-01 0.038 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 9.166983e-01 0.038 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.166983e-01 0.038 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.166983e-01 0.038 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.166983e-01 0.038 0 0
Glutathione synthesis and recycling R-HSA-174403 9.166983e-01 0.038 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.183583e-01 0.037 0 0
Nucleotide biosynthesis R-HSA-8956320 9.185949e-01 0.037 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.240298e-01 0.034 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.240298e-01 0.034 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.240298e-01 0.034 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 9.240298e-01 0.034 0 0
LDL clearance R-HSA-8964038 9.240298e-01 0.034 0 0
Signaling by KIT in disease R-HSA-9669938 9.240298e-01 0.034 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.240298e-01 0.034 0 0
RAS processing R-HSA-9648002 9.242144e-01 0.034 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.242144e-01 0.034 0 0
Signaling by ALK R-HSA-201556 9.242144e-01 0.034 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.273065e-01 0.033 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.296725e-01 0.032 0 0
Tryptophan catabolism R-HSA-71240 9.296725e-01 0.032 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.307164e-01 0.031 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.307164e-01 0.031 0 0
Formation of the ureteric bud R-HSA-9830674 9.307164e-01 0.031 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.307164e-01 0.031 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.307164e-01 0.031 0 0
Carnitine shuttle R-HSA-200425 9.307164e-01 0.031 0 0
Interleukin-20 family signaling R-HSA-8854691 9.307164e-01 0.031 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.319808e-01 0.031 0 0
Interferon gamma signaling R-HSA-877300 9.326843e-01 0.030 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 9.347575e-01 0.029 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.368149e-01 0.028 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.368149e-01 0.028 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.368149e-01 0.028 0 0
Complex III assembly R-HSA-9865881 9.368149e-01 0.028 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.368149e-01 0.028 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 9.394925e-01 0.027 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.394925e-01 0.027 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.423769e-01 0.026 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.423769e-01 0.026 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.423769e-01 0.026 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 9.423769e-01 0.026 0 0
Laminin interactions R-HSA-3000157 9.423769e-01 0.026 0 0
Signaling by ERBB4 R-HSA-1236394 9.428899e-01 0.026 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.438999e-01 0.025 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.452283e-01 0.024 0 0
MET activates PTK2 signaling R-HSA-8874081 9.474496e-01 0.023 0 0
Urea cycle R-HSA-70635 9.474496e-01 0.023 0 0
Sphingolipid catabolism R-HSA-9845614 9.474496e-01 0.023 0 0
Abacavir ADME R-HSA-2161522 9.474496e-01 0.023 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.474496e-01 0.023 0 0
GABA receptor activation R-HSA-977443 9.487879e-01 0.023 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.491474e-01 0.023 0 0
Cyclin D associated events in G1 R-HSA-69231 9.518144e-01 0.021 0 0
G1 Phase R-HSA-69236 9.518144e-01 0.021 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 9.518186e-01 0.021 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.520760e-01 0.021 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.520760e-01 0.021 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.520760e-01 0.021 0 0
Signaling by BMP R-HSA-201451 9.520760e-01 0.021 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.520760e-01 0.021 0 0
PLC beta mediated events R-HSA-112043 9.521311e-01 0.021 0 0
mitochondrial fatty acid beta-oxidation of saturated fatty acids R-HSA-77286 9.553601e-01 0.020 0 0
DAG and IP3 signaling R-HSA-1489509 9.553601e-01 0.020 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 9.562954e-01 0.019 0 0
Prednisone ADME R-HSA-9757110 9.562954e-01 0.019 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.586552e-01 0.018 0 0
Thyroxine biosynthesis R-HSA-209968 9.601435e-01 0.018 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.601435e-01 0.018 0 0
Platelet calcium homeostasis R-HSA-418360 9.601435e-01 0.018 0 0
Termination of translesion DNA synthesis R-HSA-5656169 9.601435e-01 0.018 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.601435e-01 0.018 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 9.603417e-01 0.018 0 0
Synthesis of PC R-HSA-1483191 9.617164e-01 0.017 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 9.636530e-01 0.016 0 0
Stimuli-sensing channels R-HSA-2672351 9.637829e-01 0.016 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.668536e-01 0.015 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 9.668536e-01 0.015 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.671986e-01 0.014 0 0
G-protein mediated events R-HSA-112040 9.682688e-01 0.014 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.682688e-01 0.014 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.696482e-01 0.013 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.703988e-01 0.013 0 0
The phototransduction cascade R-HSA-2514856 9.719209e-01 0.012 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 9.724347e-01 0.012 0 0
Cardiogenesis R-HSA-9733709 9.724347e-01 0.012 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 9.730889e-01 0.012 0 0
COPII-mediated vesicle transport R-HSA-204005 9.742594e-01 0.011 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.747700e-01 0.011 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.748625e-01 0.011 0 0
Heme degradation R-HSA-189483 9.748625e-01 0.011 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.770766e-01 0.010 0 0
Signaling by NOTCH2 R-HSA-1980145 9.770766e-01 0.010 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.790958e-01 0.009 0 0
Leishmania infection R-HSA-9658195 9.803395e-01 0.009 0 0
Parasitic Infection Pathways R-HSA-9824443 9.803395e-01 0.009 0 0
Neurotransmitter release cycle R-HSA-112310 9.805568e-01 0.009 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.805928e-01 0.009 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.809372e-01 0.008 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 9.810305e-01 0.008 0 0
Ion homeostasis R-HSA-5578775 9.810305e-01 0.008 0 0
RSV-host interactions R-HSA-9833110 9.814393e-01 0.008 0 0
Iron uptake and transport R-HSA-917937 9.819263e-01 0.008 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.823714e-01 0.008 0 0
NCAM1 interactions R-HSA-419037 9.826166e-01 0.008 0 0
Voltage gated Potassium channels R-HSA-1296072 9.826166e-01 0.008 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.826166e-01 0.008 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.826166e-01 0.008 0 0
Collagen chain trimerization R-HSA-8948216 9.826166e-01 0.008 0 0
Dual incision in TC-NER R-HSA-6782135 9.838062e-01 0.007 0 0
Elastic fibre formation R-HSA-1566948 9.841481e-01 0.007 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.841481e-01 0.007 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.841481e-01 0.007 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.846695e-01 0.007 0 0
Extension of Telomeres R-HSA-180786 9.850418e-01 0.007 0 0
Triglyceride metabolism R-HSA-8979227 9.850418e-01 0.007 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.850733e-01 0.007 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.855447e-01 0.006 0 0
RAB geranylgeranylation R-HSA-8873719 9.861854e-01 0.006 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.861854e-01 0.006 0 0
Neddylation R-HSA-8951664 9.865974e-01 0.006 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 9.868184e-01 0.006 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.869392e-01 0.006 0 0
Collagen degradation R-HSA-1442490 9.872438e-01 0.006 0 0
MAP kinase activation R-HSA-450294 9.872438e-01 0.006 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.877104e-01 0.005 0 0
Maturation of spike protein R-HSA-9694548 9.879799e-01 0.005 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.890391e-01 0.005 0 0
Complex I biogenesis R-HSA-6799198 9.891286e-01 0.005 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.893110e-01 0.005 0 0
Methylation R-HSA-156581 9.916892e-01 0.004 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.916892e-01 0.004 0 0
Surfactant metabolism R-HSA-5683826 9.916892e-01 0.004 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.918545e-01 0.004 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.920939e-01 0.003 0 0
PI Metabolism R-HSA-1483255 9.924080e-01 0.003 0 0
Cardiac conduction R-HSA-5576891 9.925685e-01 0.003 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.930898e-01 0.003 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.936989e-01 0.003 0 0
Interleukin-17 signaling R-HSA-448424 9.938169e-01 0.003 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.942544e-01 0.003 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.942990e-01 0.002 0 0
Metabolism of cofactors R-HSA-8978934 9.942990e-01 0.002 0 0
ECM proteoglycans R-HSA-3000178 9.942990e-01 0.002 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.952229e-01 0.002 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.955346e-01 0.002 0 0
Complex IV assembly R-HSA-9864848 9.956441e-01 0.002 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.956441e-01 0.002 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.958848e-01 0.002 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.962679e-01 0.002 0 0
Interleukin-10 signaling R-HSA-6783783 9.967813e-01 0.001 0 0
Metabolism of nucleotides R-HSA-15869 9.969133e-01 0.001 0 0
Paracetamol ADME R-HSA-9753281 9.969891e-01 0.001 0 0
Keratinization R-HSA-6805567 9.970084e-01 0.001 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.972546e-01 0.001 0 0
Synthesis of PA R-HSA-1483166 9.974968e-01 0.001 0 0
Dectin-2 family R-HSA-5621480 9.974968e-01 0.001 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.976718e-01 0.001 0 0
Innate Immune System R-HSA-168249 9.980100e-01 0.001 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.980369e-01 0.001 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.981025e-01 0.001 0 0
Glutathione conjugation R-HSA-156590 9.981025e-01 0.001 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.981304e-01 0.001 0 0
Ion channel transport R-HSA-983712 9.986811e-01 0.001 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.986887e-01 0.001 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.989023e-01 0.000 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.989099e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.990061e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.990061e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.990938e-01 0.000 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.991456e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.991628e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.992468e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.993133e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.993133e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.995255e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.995635e-01 0.000 0 0
PPARA activates gene expression R-HSA-1989781 9.995919e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.996404e-01 0.000 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.996462e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.996722e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.996722e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.997205e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.997357e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.998397e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.998420e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.998436e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.998572e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.998614e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.998731e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.998804e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.999130e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999411e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999435e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999485e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999577e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999731e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999783e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999783e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999813e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999883e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999890e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999907e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999932e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999956e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999961e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.999962e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999968e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999975e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.999978e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999981e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999986e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999987e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999993e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999997e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999997e-01 0.000 0 0
Fatty acid metabolism R-HSA-8978868 9.999997e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999998e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999999e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999999e-01 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways