TNNI3K

TYR version of PSPA with Y as phospho-acceptor

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

Y Sites Probabilities

Log-Odds: Y Sites / Y Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

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substrate_uniprot	site	source	substrate_genes	site_seq
A5A3E0	Y940	Sugiyama	POTEF A26C1B	ALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPEA
O43707	Y212	Sugiyama	ACTN4	WKDGLAFNALIHRHRPELIEyDKLRKDDPVTNLNNAFEVAE
O43707	Y878	Sugiyama	ACTN4	DKNFITAEELRRELPPDQAEyCIARMAPyQGPDAVPGALDy
O43852	Y187	Sugiyama	CALU	GDLIATKEEFtAFLHPEEyDyMKDIVVQEtMEDIDKNADGF
O60664	Y95	Sugiyama	PLIN3 M6PRBP1 TIP47	VsGAQPILSKLEPQIAsAsEyAHRGLDKLEENLPILQQPTE
O60739	Y30	Sugiyama	EIF1B	FDPFADATKGDDLLPAGTEDyIHIRIQQRNGRKtLttVQGI
P00966	Y163	Sugiyama	ASS1 ASS	APWRMPEFYNRFKGRNDLMEyAKQHGIPIPVtPKNPWSMDE
P02786	Y152	Sugiyama	TFRC	sEKLDstDFTGtIKLLNENsyVPREAGsQKDENLALyVENQ
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P07237	Y94	Sugiyama	P4HB ERBA2L PDI PDIA1 PO4DB	GSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFFRNGDTASPK
P07900	Y309	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	ELNKtKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHF
P07900	Y313	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	tKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEG
P08238	Y301	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	ELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHF
P08238	Y305	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	tKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEG
P08238	Y472	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	sELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItGEsKE
P08238	Y485	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	EMtsLsEyVsRMKEtQKsIyyItGEsKEQVANsAFVERVRK
P10809	Y243	Sugiyama	HSPD1 HSP60	yIsPyFINtsKGQKCEFQDAyVLLsEKKIssIQsIVPALEI
P11142	Y545	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	YKAEDEKQRDKVssKNsLEsyAFNMKATVEDEKLQGKINDE
P12814	Y859	Sugiyama	ACTN1	DKNyITMDELRRELPPDQAEyCIARMAPYTGPDSVPGALDY
P13674	Y282	Sugiyama	P4HA1 P4HA	ASDDQSDQKTTPKKKGVAVDyLPERQKyEMLCRGEGIKMTP
P14314	Y106	Sugiyama	PRKCSH G19P1	yIPSNRVNDGVCDCCDGtDEyNsGVICENtCKEKGRKEREs
P14625	Y527	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	AKLLRFQssHHPtDItsLDQyVERMKEKQDKIyFMAGsSRK
P17812	Y473	Sugiyama	CTPS1 CTPS	RRtLFQTKNsVMRKLyGDADyLEERHRHRFEVNPVWKKCLE
P20618	Y158	Sugiyama	PSMB1 PSC5	IGGLDEEGKGAVysFDPVGsyQRDsFKAGGSASAMLQPLLD
P25398	Y127	Sugiyama	RPS12	sCVVVKDYGKESQAKDVIEEyFKCKK_______________
P26639	T629	Sugiyama	TARS1 TARS	GGKWPFWLSPRQVMVVPVGPtCDEyAQKVRQQFHDAKFMAD
P30086	Y176	Sugiyama	PEBP1 PBP PEBP	KKyELRAPVAGtCyQAEWDDyVPKLyEQLsGK_________
P31327	Y1450	Sugiyama	CPS1	GsIDLVINLPNNNTKFVHDNyVIRRTAVDSGIPLLTNFQVT
P31943	Y266	Sugiyama	HNRNPH1 HNRPH HNRPH1	yNGYNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGstFQst
P31948	Y354	Sugiyama	STIP1	DVLKKCQQAEKILKEQERLAyINPDLALEEKNKGNECFQKG
P34932	S31	Sugiyama	HSPA4 APG2 HSPH2	QSCYVAVARAGGIETIANEysDRCtPACIsFGPKNRSIGAA
P38646	Y118	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	ERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIK
P41567	Y30	Sugiyama	EIF1 SUI1	FDPFADAsKGDDLLPAGTEDyIHIRIQQRNGRKtLttVQGI
P46777	Y207	Sugiyama	RPL5 MSTP030	sKEFNAEVHRKHIMGQNVADyMRyLMEEDEDAyKKQFsQyI
P46777	Y226	Sugiyama	RPL5 MSTP030	DyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAHAA
P46937	S109	Sugiyama	YAP1 YAP65	RKLPDsFFKPPEPKsHsRQAstDAGtAGALtPQHVRAHssP
P48643	Y274	Sugiyama	CCT5 CCTE KIAA0098	PFEPPKPKTKHKLDVtsVEDyKALQKYEKEKFEEMIQQIKE
P52597	Y266	Sugiyama	HNRNPF HNRPF	ySGLSDGYGFTTDLFGRDLsyCLsGMyDHRYGDsEFtVQsT
P52888	Y576	Sugiyama	THOP1	VLAKVDQALHTQTDADPAEEyARLCQEILGVPATPGTNMPA
P55795	Y266	Sugiyama	HNRNPH2 FTP3 HNRPH2	YGGYNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGssFQst
P60660	Y89	Sugiyama	MYL6	HFLPMLQTVAKNKDQGtyEDyVEGLRVFDKEGNGtVMGAEI
P60709	Y198	Sugiyama	ACTB	LDLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCy
P60709	Y240	Sugiyama	ACTB	ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P62258	Y152	Sugiyama	YWHAE	LAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHPIRLG
P62258	Y214	Sugiyama	YWHAE	LAKAAFDDAIAELDtLsEEsyKDstLIMQLLRDNLtLWtsD
P62273	Y7	Sugiyama	RPS29	______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62736	Y242	Sugiyama	ACTA2 ACTSA ACTVS GIG46	ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P63261	Y198	Sugiyama	ACTG1 ACTG	LDLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCy
P63261	Y240	Sugiyama	ACTG1 ACTG	ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P63267	Y241	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68032	Y242	Sugiyama	ACTC1 ACTC	ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68133	Y242	Sugiyama	ACTA1 ACTA	ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
Q00839	Y260	Sugiyama	HNRNPU C1orf199 HNRPU SAFA U21.1	GDKKRGVKRPREDHGRGyFEyIEENKysRAKsPQPPVEEED
Q06830	Y116	Sugiyama	PRDX1 PAGA PAGB TDPX2	GLGPMNIPLVSDPKRtIAQDyGVLKADEGIsFRGLFIIDDK
Q15185	S113	Sugiyama	PTGES3 P23 TEBP	RAKLNWLsVDFNNWKDWEDDsDEDMsNFDRFSEMMNNMGGD
Q16719	Y47	Sugiyama	KYNU	ERVALHLDEEDKLRHFRECFyIPKIQDLPPVDLSLVNKDEN
Q562R1	Y241	Sugiyama	ACTBL2	ALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPEA
Q58FF8	Y261	Sugiyama	HSP90AB2P HSP90BB	RYFSVEEYVSRMKEIQKsIyyItGEsKEQVANSAFVEQVWK
Q59H18	S424	Sugiyama	TNNI3K CARK	YKRPQDELPCNEYSQPGGDGsyVsVPsPLGKIKSMTKEKAD
Q59H18	S427	Sugiyama	TNNI3K CARK	PQDELPCNEYSQPGGDGsyVsVPsPLGKIKSMTKEKADILL
Q59H18	S430	Sugiyama	TNNI3K CARK	ELPCNEYSQPGGDGsyVsVPsPLGKIKSMTKEKADILLLRA
Q59H18	S615	Sugiyama	TNNI3K CARK	LLYEDGHAVVADFGESRFLQsLDEDNMtKQPGNLRWMAPEV
Q59H18	T622	Sugiyama	TNNI3K CARK	AVVADFGESRFLQsLDEDNMtKQPGNLRWMAPEVFTQCTRY
Q59H18	Y390	Sugiyama	TNNI3K CARK	ACDPSRSSGEKDEQTCLMWAyEKGHDAIVTLLKHYKRPQDE
Q59H18	Y425	Sugiyama	TNNI3K CARK	KRPQDELPCNEYSQPGGDGsyVsVPsPLGKIKSMTKEKADI
Q6S8J3	Y940	Sugiyama	POTEE A26C1A POTE2	ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
Q86W56	Y832	Sugiyama	PARG	DDWQRRCTEIVAIDALHFRRyLDQFVPEKMRRELNKAYCGF
Q9BYX7	Y240	Sugiyama	POTEKP ACTBL3 FKSG30	ALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPEA
Q9UBR2	Y76	Sugiyama	CTSZ	YLSPADLPKSWDWRNVDGVNyAsItRNQHIPQYCGSCWAHA
Q9Y617	Y230	Sugiyama	PSAT1 PSA	VIVRDDLLGFALRECPsVLEyKVQAGNSSLYNTPPCFSIYV

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p
Cytokine Signaling in Immune system	R-HSA-1280215	3.038514e-11	10.517
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	7.494703e-10	9.125
Recycling pathway of L1	R-HSA-437239	1.026220e-09	8.989
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	1.430253e-09	8.845
Signaling by ALK in cancer	R-HSA-9700206	1.430253e-09	8.845
Interferon Signaling	R-HSA-913531	7.783090e-09	8.109
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	8.103821e-09	8.091
Transport of connexons to the plasma membrane	R-HSA-190872	1.095794e-08	7.960
Post-chaperonin tubulin folding pathway	R-HSA-389977	1.927619e-08	7.715
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	4.778215e-08	7.321
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	6.588930e-08	7.181
Activation of AMPK downstream of NMDARs	R-HSA-9619483	1.523864e-07	6.817
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	2.677510e-07	6.572
L1CAM interactions	R-HSA-373760	3.390650e-07	6.470
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	3.798309e-07	6.420
Gap junction assembly	R-HSA-190861	5.289880e-07	6.277
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	7.414756e-07	6.130
PKR-mediated signaling	R-HSA-9833482	8.772178e-07	6.057
Immune System	R-HSA-168256	1.108792e-06	5.955
Interleukin-2 family signaling	R-HSA-451927	1.300519e-06	5.886
Aggrephagy	R-HSA-9646399	1.300519e-06	5.886
Kinesins	R-HSA-983189	1.291903e-06	5.889
Nervous system development	R-HSA-9675108	1.424222e-06	5.846
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	1.598413e-06	5.796
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	1.708568e-06	5.767
Axon guidance	R-HSA-422475	1.939524e-06	5.712
Gap junction trafficking	R-HSA-190828	2.517840e-06	5.599
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	2.540713e-06	5.595
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	3.624873e-06	5.441
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	4.073685e-06	5.390
Downstream signal transduction	R-HSA-186763	4.686678e-06	5.329
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	4.628194e-06	5.335
Gap junction trafficking and regulation	R-HSA-157858	4.567863e-06	5.340
Signaling by VEGF	R-HSA-194138	5.171144e-06	5.286
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	8.699400e-06	5.061
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	1.425911e-05	4.846
Signaling by ALK	R-HSA-201556	1.592268e-05	4.798
VEGFA-VEGFR2 Pathway	R-HSA-4420097	1.852813e-05	4.732
Signal Transduction	R-HSA-162582	1.793579e-05	4.746
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	2.229019e-05	4.652
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	2.530598e-05	4.597
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	2.862930e-05	4.543
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	3.353682e-05	4.474
SHC-related events triggered by IGF1R	R-HSA-2428933	3.663690e-05	4.436
Signaling by LTK	R-HSA-9842663	3.663690e-05	4.436
Cargo trafficking to the periciliary membrane	R-HSA-5620920	3.649962e-05	4.438
Intraflagellar transport	R-HSA-5620924	4.725545e-05	4.326
SHC1 events in ERBB2 signaling	R-HSA-1250196	6.167962e-05	4.210
Signaling by FGFR2	R-HSA-5654738	7.139261e-05	4.146
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	7.139261e-05	4.146
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	7.855576e-05	4.105
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	8.715544e-05	4.060
Striated Muscle Contraction	R-HSA-390522	1.007483e-04	3.997
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	1.297457e-04	3.887
Interferon alpha/beta signaling	R-HSA-909733	1.215505e-04	3.915
Signaling by NTRKs	R-HSA-166520	1.259659e-04	3.900
Chaperonin-mediated protein folding	R-HSA-390466	1.218014e-04	3.914
Selective autophagy	R-HSA-9663891	1.297457e-04	3.887
Post NMDA receptor activation events	R-HSA-438064	1.218014e-04	3.914
Signaling by ERBB2	R-HSA-1227986	1.356094e-04	3.868
Signaling by Interleukins	R-HSA-449147	1.388025e-04	3.858
Signaling by PDGF	R-HSA-186797	1.584234e-04	3.800
Protein folding	R-HSA-391251	1.760297e-04	3.754
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	1.652281e-04	3.782
MHC class II antigen presentation	R-HSA-2132295	1.823782e-04	3.739
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	2.126700e-04	3.672
Separation of Sister Chromatids	R-HSA-2467813	2.476171e-04	3.606
COPI-mediated anterograde transport	R-HSA-6807878	2.348431e-04	3.629
Signaling by FGFR	R-HSA-190236	2.623996e-04	3.581
Signaling by NTRK3 (TRKC)	R-HSA-9034015	2.698844e-04	3.569
Hedgehog 'off' state	R-HSA-5610787	2.925008e-04	3.534
Signaling by FGFR4	R-HSA-5654743	3.074060e-04	3.512
Golgi-to-ER retrograde transport	R-HSA-8856688	3.049310e-04	3.516
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	3.253163e-04	3.488
Interleukin receptor SHC signaling	R-HSA-912526	3.529771e-04	3.452
Signaling by FGFR3	R-HSA-5654741	3.659492e-04	3.437
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	4.007351e-04	3.397
Leishmania phagocytosis	R-HSA-9664417	4.492023e-04	3.348
FCGR3A-mediated phagocytosis	R-HSA-9664422	4.492023e-04	3.348
Parasite infection	R-HSA-9664407	4.492023e-04	3.348
Activated NTRK3 signals through RAS	R-HSA-9034864	5.689701e-04	3.245
Interleukin-2 signaling	R-HSA-9020558	5.689701e-04	3.245
Signaling by NTRK2 (TRKB)	R-HSA-9006115	5.715963e-04	3.243
Activated NTRK2 signals through RAS	R-HSA-9026519	6.940733e-04	3.159
Signaling by Erythropoietin	R-HSA-9006335	7.108095e-04	3.148
Signaling by ERBB2 KD Mutants	R-HSA-9664565	7.108095e-04	3.148
Downstream signaling of activated FGFR3	R-HSA-5654708	7.108095e-04	3.148
Potential therapeutics for SARS	R-HSA-9679191	6.961628e-04	3.157
Disease	R-HSA-1643685	6.503945e-04	3.187
DAP12 signaling	R-HSA-2424491	7.887088e-04	3.103
Downstream signaling of activated FGFR4	R-HSA-5654716	7.887088e-04	3.103
Signaling by ERBB2 in Cancer	R-HSA-1227990	7.887088e-04	3.103
RAF/MAP kinase cascade	R-HSA-5673001	8.281331e-04	3.082
Interleukin-15 signaling	R-HSA-8983432	8.354484e-04	3.078
Signaling by FGFR1	R-HSA-5654736	8.511356e-04	3.070
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	8.511356e-04	3.070
MAPK1/MAPK3 signaling	R-HSA-5684996	9.907561e-04	3.004
Integrin signaling	R-HSA-354192	1.058400e-03	2.975
Signaling by NTRK1 (TRKA)	R-HSA-187037	1.278592e-03	2.893
Erythropoietin activates RAS	R-HSA-9027284	1.364948e-03	2.865
Downstream signaling of activated FGFR2	R-HSA-5654696	1.387029e-03	2.858
Downstream signaling of activated FGFR1	R-HSA-5654687	1.387029e-03	2.858
Mitotic Anaphase	R-HSA-68882	1.537232e-03	2.813
Mitotic Metaphase and Anaphase	R-HSA-2555396	1.581808e-03	2.801
Hemostasis	R-HSA-109582	1.936708e-03	2.713
Signaling by EGFRvIII in Cancer	R-HSA-5637812	2.067454e-03	2.685
Constitutive Signaling by EGFRvIII	R-HSA-5637810	2.067454e-03	2.685
FLT3 Signaling	R-HSA-9607240	2.246377e-03	2.649
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	2.163470e-03	2.665
Leishmania infection	R-HSA-9658195	2.338867e-03	2.631
Parasitic Infection Pathways	R-HSA-9824443	2.338867e-03	2.631
Signaling by Hedgehog	R-HSA-5358351	2.010456e-03	2.697
Macroautophagy	R-HSA-1632852	2.236062e-03	2.651
Tie2 Signaling	R-HSA-210993	2.343110e-03	2.630
Signaling by ERBB2 ECD mutants	R-HSA-9665348	2.343110e-03	2.630
G2/M Transition	R-HSA-69275	2.416987e-03	2.617
Mitotic G2-G2/M phases	R-HSA-453274	2.563673e-03	2.591
Regulation of signaling by CBL	R-HSA-912631	2.640500e-03	2.578
ER to Golgi Anterograde Transport	R-HSA-199977	2.838487e-03	2.547
Mitotic Prometaphase	R-HSA-68877	2.960987e-03	2.529
DAP12 interactions	R-HSA-2172127	2.988897e-03	2.524
Cellular responses to stimuli	R-HSA-8953897	3.066294e-03	2.513
MAPK family signaling cascades	R-HSA-5683057	3.152972e-03	2.501
SHC-mediated cascade:FGFR3	R-HSA-5654704	3.302666e-03	2.481
SHC-mediated cascade:FGFR4	R-HSA-5654719	3.668470e-03	2.436
VEGF binds to VEGFR leading to receptor dimerization	R-HSA-195399	3.789931e-03	2.421
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	3.302666e-03	2.481
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	3.302666e-03	2.481
VEGF ligand-receptor interactions	R-HSA-194313	3.789931e-03	2.421
Platelet Aggregation (Plug Formation)	R-HSA-76009	3.197787e-03	2.495
Sensory processing of sound	R-HSA-9659379	3.215784e-03	2.493
Autophagy	R-HSA-9612973	3.787481e-03	2.422
Nef and signal transduction	R-HSA-164944	4.761483e-03	2.322
SHC-mediated cascade:FGFR1	R-HSA-5654688	4.910390e-03	2.309
Cell-Cell communication	R-HSA-1500931	5.037985e-03	2.298
Viral Infection Pathways	R-HSA-9824446	5.175584e-03	2.286
Infectious disease	R-HSA-5663205	5.308602e-03	2.275
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	5.835337e-03	2.234
Signaling by EGFR in Cancer	R-HSA-1643713	5.862967e-03	2.232
Myogenesis	R-HSA-525793	5.862967e-03	2.232
SHC-mediated cascade:FGFR2	R-HSA-5654699	6.377786e-03	2.195
MET receptor recycling	R-HSA-8875656	7.009111e-03	2.154
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	R-HSA-8939242	7.009111e-03	2.154
Transcriptional regulation by RUNX1	R-HSA-8878171	7.082463e-03	2.150
Developmental Biology	R-HSA-1266738	7.111689e-03	2.148
Signaling by CSF3 (G-CSF)	R-HSA-9674555	7.486163e-03	2.126
Interleukin-21 signaling	R-HSA-9020958	8.280462e-03	2.082
MET activates RAP1 and RAC1	R-HSA-8875555	9.647086e-03	2.016
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	9.647086e-03	2.016
Signal attenuation	R-HSA-74749	9.647086e-03	2.016
IGF1R signaling cascade	R-HSA-2428924	9.248225e-03	2.034
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	9.689384e-03	2.014
Cilium Assembly	R-HSA-5617833	9.891722e-03	2.005
Evasion by RSV of host interferon responses	R-HSA-9833109	8.701521e-03	2.060
Signaling by PTK6	R-HSA-8848021	8.820373e-03	2.055
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	8.820373e-03	2.055
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	9.689384e-03	2.014
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	1.109422e-02	1.955
ChREBP activates metabolic gene expression	R-HSA-163765	1.110672e-02	1.954
TLR3 deficiency - HSE	R-HSA-5602410	1.117755e-02	1.952
HCMV Early Events	R-HSA-9609690	1.141183e-02	1.943
HCMV Infection	R-HSA-9609646	1.192727e-02	1.923
Signalling to ERKs	R-HSA-187687	1.222108e-02	1.913
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	1.262412e-02	1.899
Activation of RAC1	R-HSA-428540	1.265714e-02	1.898
RET signaling	R-HSA-8853659	1.300910e-02	1.886
Transport to the Golgi and subsequent modification	R-HSA-948021	1.309469e-02	1.883
Cellular responses to stress	R-HSA-2262752	1.349200e-02	1.870
MET activates RAS signaling	R-HSA-8851805	1.429615e-02	1.845
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	1.429615e-02	1.845
ISG15 antiviral mechanism	R-HSA-1169408	1.486481e-02	1.828
Interleukin-12 signaling	R-HSA-9020591	1.546167e-02	1.811
Cell Cycle, Mitotic	R-HSA-69278	1.595974e-02	1.797
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	1.602160e-02	1.795
Generation of second messenger molecules	R-HSA-202433	1.644661e-02	1.784
M Phase	R-HSA-68886	1.646527e-02	1.783
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	1.663212e-02	1.779
Signaling by FGFR4 in disease	R-HSA-5655291	1.783138e-02	1.749
Regulation of KIT signaling	R-HSA-1433559	1.783138e-02	1.749
TICAM1 deficiency - HSE	R-HSA-5602566	2.223085e-02	1.653
UNC93B1 deficiency - HSE	R-HSA-5602415	2.223085e-02	1.653
SHC1 events in EGFR signaling	R-HSA-180336	1.972341e-02	1.705
SHC1 events in ERBB4 signaling	R-HSA-1250347	2.374608e-02	1.624
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	2.246893e-02	1.648
Inhibition of PKR	R-HSA-169131	2.223085e-02	1.653
Netrin-1 signaling	R-HSA-373752	2.139264e-02	1.670
Spry regulation of FGF signaling	R-HSA-1295596	1.972341e-02	1.705
Negative regulation of FLT3	R-HSA-9706369	2.169564e-02	1.664
Membrane Trafficking	R-HSA-199991	1.956136e-02	1.709
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	1.972341e-02	1.705
Intracellular signaling by second messengers	R-HSA-9006925	2.208092e-02	1.656
XBP1(S) activates chaperone genes	R-HSA-381038	2.303274e-02	1.638
Interleukin-12 family signaling	R-HSA-447115	2.381476e-02	1.623
NGF-stimulated transcription	R-HSA-9031628	2.587213e-02	1.587
GPER1 signaling	R-HSA-9634597	2.587213e-02	1.587
PI3K events in ERBB2 signaling	R-HSA-1963642	2.587273e-02	1.587
Specification of primordial germ cells	R-HSA-9827857	2.587273e-02	1.587
PIP3 activates AKT signaling	R-HSA-1257604	2.697802e-02	1.569
IRE1alpha activates chaperones	R-HSA-381070	2.796531e-02	1.553
Ephrin signaling	R-HSA-3928664	2.807367e-02	1.552
Signaling by FGFR2 in disease	R-HSA-5655253	2.828598e-02	1.548
Adaptive Immune System	R-HSA-1280218	3.215631e-02	1.493
Unfolded Protein Response (UPR)	R-HSA-381119	3.239280e-02	1.490
Nephrin family interactions	R-HSA-373753	3.269079e-02	1.486
TRAF3 deficiency - HSE	R-HSA-5602571	3.316127e-02	1.479
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	R-HSA-9632700	3.316127e-02	1.479
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	R-HSA-9630794	3.316127e-02	1.479
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects	R-HSA-9630750	3.316127e-02	1.479
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects	R-HSA-9632693	3.316127e-02	1.479
Translation initiation complex formation	R-HSA-72649	3.345994e-02	1.475
mRNA Splicing - Major Pathway	R-HSA-72163	3.428705e-02	1.465
Cell-cell junction organization	R-HSA-421270	3.456907e-02	1.461
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	3.510327e-02	1.455
Signalling to RAS	R-HSA-167044	3.510327e-02	1.455
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	3.510327e-02	1.455
Ribosomal scanning and start codon recognition	R-HSA-72702	3.621878e-02	1.441
Signaling by EGFR	R-HSA-177929	3.621878e-02	1.441
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	3.758260e-02	1.425
Listeria monocytogenes entry into host cells	R-HSA-8876384	3.758260e-02	1.425
Signaling by PDGFR in disease	R-HSA-9671555	3.758260e-02	1.425
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	3.909109e-02	1.408
Organelle biogenesis and maintenance	R-HSA-1852241	3.947246e-02	1.404
Regulation of IFNA/IFNB signaling	R-HSA-912694	4.012700e-02	1.397
FGFR2 alternative splicing	R-HSA-6803529	4.012700e-02	1.397
Notch-HLH transcription pathway	R-HSA-350054	4.012700e-02	1.397
Signaling by ROBO receptors	R-HSA-376176	4.055532e-02	1.392
Response of endothelial cells to shear stress	R-HSA-9860931	4.175740e-02	1.379
mRNA Splicing	R-HSA-72172	4.204055e-02	1.376
Regulation of PTEN gene transcription	R-HSA-8943724	4.207588e-02	1.376
Interleukin-20 family signaling	R-HSA-8854691	4.273473e-02	1.369
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	4.273473e-02	1.369
RSV-host interactions	R-HSA-9833110	4.286619e-02	1.368
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	5.465887e-02	1.262
PLC-gamma1 signalling	R-HSA-167021	5.465887e-02	1.262
Activated NTRK3 signals through PLCG1	R-HSA-9034793	5.465887e-02	1.262
MET activates PTPN11	R-HSA-8865999	5.465887e-02	1.262
Invadopodia formation	R-HSA-8941237	5.465887e-02	1.262
Activated NTRK2 signals through PLCG1	R-HSA-9026527	6.522874e-02	1.186
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	6.522874e-02	1.186
PLCG1 events in ERBB2 signaling	R-HSA-1251932	6.522874e-02	1.186
GRB7 events in ERBB2 signaling	R-HSA-1306955	6.522874e-02	1.186
MITF-M-regulated melanocyte development	R-HSA-9730414	4.914636e-02	1.309
FCERI mediated MAPK activation	R-HSA-2871796	5.233027e-02	1.281
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	5.337358e-02	1.273
Role of phospholipids in phagocytosis	R-HSA-2029485	5.877824e-02	1.231
Neurophilin interactions with VEGF and VEGFR	R-HSA-194306	4.397016e-02	1.357
Regulation of cortical dendrite branching	R-HSA-8985801	4.397016e-02	1.357
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	5.465887e-02	1.262
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	6.522874e-02	1.186
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	6.227541e-02	1.206
FCERI mediated Ca+2 mobilization	R-HSA-2871809	5.877824e-02	1.231
Signaling by FGFR3 in disease	R-HSA-5655332	5.376502e-02	1.270
Negative regulation of FGFR3 signaling	R-HSA-5654732	5.666423e-02	1.247
Negative regulation of FGFR4 signaling	R-HSA-5654733	5.961691e-02	1.225
Diseases of cellular response to stress	R-HSA-9675132	4.397016e-02	1.357
Diseases of Cellular Senescence	R-HSA-9630747	4.397016e-02	1.357
VEGFR2 mediated cell proliferation	R-HSA-5218921	4.813332e-02	1.318
TCR signaling	R-HSA-202403	4.986550e-02	1.302
FLT3 signaling through SRC family kinases	R-HSA-9706374	6.522874e-02	1.186
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	5.666423e-02	1.247
Adherens junctions interactions	R-HSA-418990	5.339568e-02	1.272
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	5.092085e-02	1.293
Cell junction organization	R-HSA-446728	5.261008e-02	1.279
Cellular responses to mechanical stimuli	R-HSA-9855142	5.486055e-02	1.261
PI3K/AKT Signaling in Cancer	R-HSA-2219528	6.284167e-02	1.202
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	5.376502e-02	1.270
Signaling by FGFR in disease	R-HSA-1226099	6.600975e-02	1.180
Signaling by NOTCH4	R-HSA-9013694	6.600975e-02	1.180
Signaling by ERBB4	R-HSA-1236394	6.600975e-02	1.180
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	6.688849e-02	1.175
Regulation of CDH1 Expression and Function	R-HSA-9764265	6.688849e-02	1.175
Cell Cycle	R-HSA-1640170	6.895542e-02	1.161
Negative regulation of FGFR1 signaling	R-HSA-5654726	7.193191e-02	1.143
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	7.193191e-02	1.143
Regulation of MECP2 expression and activity	R-HSA-9022692	7.193191e-02	1.143
Signaling by NOTCH	R-HSA-157118	7.468304e-02	1.127
Regulation of MITF-M dependent genes involved in invasion	R-HSA-9854909	7.568106e-02	1.121
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	7.568106e-02	1.121
Co-inhibition by BTLA	R-HSA-9927353	7.568106e-02	1.121
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	7.568106e-02	1.121
Nectin/Necl trans heterodimerization	R-HSA-420597	7.568106e-02	1.121
Signaling by MET	R-HSA-6806834	7.780831e-02	1.109
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	7.780831e-02	1.109
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	7.837141e-02	1.106
Negative regulation of FGFR2 signaling	R-HSA-5654727	7.837141e-02	1.106
FLT3 signaling in disease	R-HSA-9682385	8.498387e-02	1.071
RUNX2 regulates bone development	R-HSA-8941326	8.498387e-02	1.071
Vesicle-mediated transport	R-HSA-5653656	8.542115e-02	1.068
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	8.601715e-02	1.065
Noncanonical activation of NOTCH3	R-HSA-9017802	8.601715e-02	1.065
Defective CSF2RA causes SMDP4	R-HSA-5688890	8.601715e-02	1.065
Defective CSF2RB causes SMDP5	R-HSA-5688849	8.601715e-02	1.065
Regulation of CDH19 Expression and Function	R-HSA-9764302	8.601715e-02	1.065
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	8.835159e-02	1.054
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	9.102481e-02	1.041
MET promotes cell motility	R-HSA-8875878	9.175854e-02	1.037
Transmission across Chemical Synapses	R-HSA-112315	9.392060e-02	1.027
Erythropoietin activates STAT5	R-HSA-9027283	9.623830e-02	1.017
STAT5 Activation	R-HSA-9645135	9.623830e-02	1.017
SOS-mediated signalling	R-HSA-112412	1.063458e-01	0.973
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	1.163408e-01	0.934
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	1.163408e-01	0.934
EGFR interacts with phospholipase C-gamma	R-HSA-212718	1.163408e-01	0.934
Activated NTRK2 signals through PI3K	R-HSA-9028335	1.163408e-01	0.934
ARMS-mediated activation	R-HSA-170984	1.262247e-01	0.899
ALK mutants bind TKIs	R-HSA-9700645	1.262247e-01	0.899
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	1.359986e-01	0.866
RHOBTB3 ATPase cycle	R-HSA-9706019	1.456638e-01	0.837
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	1.646727e-01	0.783
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	1.646727e-01	0.783
GRB2 events in EGFR signaling	R-HSA-179812	1.646727e-01	0.783
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	1.740189e-01	0.759
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	1.832610e-01	0.737
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	1.832610e-01	0.737
mRNA Splicing - Minor Pathway	R-HSA-72165	1.239820e-01	0.907
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	1.782686e-01	0.749
MITF-M-dependent gene expression	R-HSA-9856651	1.223177e-01	0.913
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	1.552214e-01	0.809
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	1.205185e-01	0.919
CD28 dependent Vav1 pathway	R-HSA-389359	1.740189e-01	0.759
MET activates PI3K/AKT signaling	R-HSA-8851907	1.063458e-01	0.973
Regulation of CDH11 function	R-HSA-9762292	1.359986e-01	0.866
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	1.456638e-01	0.837
EPHB-mediated forward signaling	R-HSA-3928662	1.166006e-01	0.933
EPH-Ephrin signaling	R-HSA-2682334	1.085538e-01	0.964
G1 Phase	R-HSA-69236	1.166006e-01	0.933
Cyclin D associated events in G1	R-HSA-69231	1.166006e-01	0.933
Interleukin-9 signaling	R-HSA-8985947	1.163408e-01	0.934
Cap-dependent Translation Initiation	R-HSA-72737	1.809394e-01	0.742
TET1,2,3 and TDG demethylate DNA	R-HSA-5221030	1.359986e-01	0.866
Processing of SMDT1	R-HSA-8949664	1.740189e-01	0.759
Regulation of RAS by GAPs	R-HSA-5658442	1.390650e-01	0.857
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	1.022020e-01	0.991
Eukaryotic Translation Initiation	R-HSA-72613	1.809394e-01	0.742
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	9.623830e-02	1.017
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	1.646727e-01	0.783
Role of second messengers in netrin-1 signaling	R-HSA-418890	1.646727e-01	0.783
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	1.740189e-01	0.759
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	9.868501e-02	1.006
Regulation of CDH1 Function	R-HSA-9764561	1.663192e-01	0.779
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	1.132820e-01	0.946
Trafficking and processing of endosomal TLR	R-HSA-1679131	1.646727e-01	0.783
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	1.109081e-01	0.955
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	1.068002e-01	0.971
HDACs deacetylate histones	R-HSA-3214815	1.584352e-01	0.800
Signaling by FGFR1 in disease	R-HSA-5655302	1.057533e-01	0.976
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	9.868501e-02	1.006
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	9.868501e-02	1.006
EGFR Transactivation by Gastrin	R-HSA-2179392	1.359986e-01	0.866
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	1.740189e-01	0.759
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	1.239820e-01	0.907
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	1.536958e-01	0.813
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	1.536958e-01	0.813
Co-stimulation by CD28	R-HSA-389356	1.314729e-01	0.881
Degradation of CDH1	R-HSA-9766229	1.352569e-01	0.869
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	1.646727e-01	0.783
Diseases associated with surfactant metabolism	R-HSA-5687613	1.646727e-01	0.783
Repression of WNT target genes	R-HSA-4641265	1.646727e-01	0.783
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	1.379695e-01	0.860
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	1.359986e-01	0.866
Synthesis of GDP-mannose	R-HSA-446205	1.646727e-01	0.783
Reversible hydration of carbon dioxide	R-HSA-1475029	1.740189e-01	0.759
Signaling by SCF-KIT	R-HSA-1433557	1.129537e-01	0.947
Mitotic G1 phase and G1/S transition	R-HSA-453279	1.147967e-01	0.940
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	1.646727e-01	0.783
Disorders of Nervous System Development	R-HSA-9697154	1.646727e-01	0.783
Pervasive developmental disorders	R-HSA-9005895	1.646727e-01	0.783
Formation of the active cofactor, UDP-glucuronate	R-HSA-173599	1.832610e-01	0.737
Cellular response to mitochondrial stress	R-HSA-9840373	1.262247e-01	0.899
RNA Polymerase I Transcription Initiation	R-HSA-73762	1.093376e-01	0.961
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	9.661250e-02	1.015
Platelet activation, signaling and aggregation	R-HSA-76002	1.157863e-01	0.936
Innate Immune System	R-HSA-168249	1.838470e-01	0.736
PECAM1 interactions	R-HSA-210990	1.456638e-01	0.837
Suppression of apoptosis	R-HSA-9635465	1.456638e-01	0.837
VEGFR2 mediated vascular permeability	R-HSA-5218920	1.022020e-01	0.991
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	1.406067e-01	0.852
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	1.262247e-01	0.899
Signal regulatory protein family interactions	R-HSA-391160	1.832610e-01	0.737
PTEN Regulation	R-HSA-6807070	1.004014e-01	0.998
Transcriptional regulation by RUNX2	R-HSA-8878166	1.893560e-01	0.723
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	1.623684e-01	0.789
Muscle contraction	R-HSA-397014	1.222288e-01	0.913
Oxidative Stress Induced Senescence	R-HSA-2559580	1.354820e-01	0.868
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	1.057533e-01	0.976
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	1.352569e-01	0.869
ESR-mediated signaling	R-HSA-8939211	1.649450e-01	0.783
Extra-nuclear estrogen signaling	R-HSA-9009391	1.329446e-01	0.876
Death Receptor Signaling	R-HSA-73887	1.300445e-01	0.886
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	1.782686e-01	0.749
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	1.782686e-01	0.749
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	1.782686e-01	0.749
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	1.782686e-01	0.749
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	1.782686e-01	0.749
p75 NTR receptor-mediated signalling	R-HSA-193704	1.279211e-01	0.893
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	9.694226e-02	1.013
Signaling by NOTCH1 in Cancer	R-HSA-2644603	1.782686e-01	0.749
Asparagine N-linked glycosylation	R-HSA-446203	1.282923e-01	0.892
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	1.903459e-01	0.720
Loss of Nlp from mitotic centrosomes	R-HSA-380259	1.903459e-01	0.720
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	1.924003e-01	0.716
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	1.924003e-01	0.716
ERBB2 Regulates Cell Motility	R-HSA-6785631	1.924003e-01	0.716
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	1.924003e-01	0.716
DCC mediated attractive signaling	R-HSA-418885	1.924003e-01	0.716
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	1.924003e-01	0.716
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	1.924003e-01	0.716
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	1.924003e-01	0.716
Insulin receptor signalling cascade	R-HSA-74751	1.943963e-01	0.711
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	2.007306e-01	0.697
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	2.014379e-01	0.696
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	2.014379e-01	0.696
Prolonged ERK activation events	R-HSA-169893	2.014379e-01	0.696
SARS-CoV Infections	R-HSA-9679506	2.020657e-01	0.695
AURKA Activation by TPX2	R-HSA-8854518	2.025295e-01	0.694
Host Interactions of HIV factors	R-HSA-162909	2.035997e-01	0.691
GRB2 events in ERBB2 signaling	R-HSA-1963640	2.103749e-01	0.677
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	2.103749e-01	0.677
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	2.103749e-01	0.677
Synthesis of PG	R-HSA-1483148	2.103749e-01	0.677
Disorders of Developmental Biology	R-HSA-9675151	2.103749e-01	0.677
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	2.122634e-01	0.673
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	2.189051e-01	0.660
Degradation of beta-catenin by the destruction complex	R-HSA-195253	2.189051e-01	0.660
Regulation of CDH1 Gene Transcription	R-HSA-9764560	2.189051e-01	0.660
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	2.192124e-01	0.659
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	2.192124e-01	0.659
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	2.192124e-01	0.659
NoRC negatively regulates rRNA expression	R-HSA-427413	2.230176e-01	0.652
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	2.230176e-01	0.652
Negative regulation of the PI3K/AKT network	R-HSA-199418	2.239370e-01	0.650
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	2.279516e-01	0.642
GAB1 signalosome	R-HSA-180292	2.279516e-01	0.642
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	2.279516e-01	0.642
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	2.279516e-01	0.642
Adipogenesis	R-HSA-9843745	2.298213e-01	0.639
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	2.312604e-01	0.636
PI-3K cascade:FGFR3	R-HSA-5654710	2.365935e-01	0.626
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	2.365935e-01	0.626
Signaling by FGFR2 IIIa TM	R-HSA-8851708	2.365935e-01	0.626
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	2.365935e-01	0.626
Centrosome maturation	R-HSA-380287	2.395227e-01	0.621
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	2.395227e-01	0.621
RNA Polymerase I Promoter Clearance	R-HSA-73854	2.436595e-01	0.613
Signaling by NOTCH1	R-HSA-1980143	2.436595e-01	0.613
PI-3K cascade:FGFR4	R-HSA-5654720	2.451392e-01	0.611
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	2.451392e-01	0.611
Negative regulation of MET activity	R-HSA-6807004	2.451392e-01	0.611
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	2.451392e-01	0.611
RNA Polymerase I Transcription	R-HSA-73864	2.519417e-01	0.599
TNFR1-induced proapoptotic signaling	R-HSA-5357786	2.535897e-01	0.596
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	2.602314e-01	0.585
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	2.619462e-01	0.582
Mitochondrial calcium ion transport	R-HSA-8949215	2.619462e-01	0.582
FRS-mediated FGFR3 signaling	R-HSA-5654706	2.619462e-01	0.582
Amyloid fiber formation	R-HSA-977225	2.643776e-01	0.578
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	R-HSA-9857377	2.702096e-01	0.568
PI-3K cascade:FGFR1	R-HSA-5654689	2.702096e-01	0.568
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	2.702096e-01	0.568
mTORC1-mediated signalling	R-HSA-166208	2.702096e-01	0.568
FRS-mediated FGFR4 signaling	R-HSA-5654712	2.702096e-01	0.568
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	2.702096e-01	0.568
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	2.702096e-01	0.568
Signaling by KIT in disease	R-HSA-9669938	2.702096e-01	0.568
Clathrin-mediated endocytosis	R-HSA-8856828	2.717083e-01	0.566
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	2.768158e-01	0.558
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	2.768158e-01	0.558
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	2.783810e-01	0.555
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	2.783810e-01	0.555
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	2.783810e-01	0.555
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	2.864614e-01	0.543
Deadenylation of mRNA	R-HSA-429947	2.864614e-01	0.543
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	2.864614e-01	0.543
Complex III assembly	R-HSA-9865881	2.864614e-01	0.543
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	2.892426e-01	0.539
PI-3K cascade:FGFR2	R-HSA-5654695	2.944518e-01	0.531
Interleukin-7 signaling	R-HSA-1266695	2.944518e-01	0.531
Tight junction interactions	R-HSA-420029	2.944518e-01	0.531
FRS-mediated FGFR1 signaling	R-HSA-5654693	2.944518e-01	0.531
Glycogen breakdown (glycogenolysis)	R-HSA-70221	2.944518e-01	0.531
ER-Phagosome pathway	R-HSA-1236974	3.016449e-01	0.521
Signaling by FLT3 fusion proteins	R-HSA-9703465	3.023532e-01	0.519
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	3.023532e-01	0.519
HIV Infection	R-HSA-162906	3.024075e-01	0.519
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	3.057715e-01	0.515
Transcriptional Regulation by MECP2	R-HSA-8986944	3.098937e-01	0.509
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	3.101667e-01	0.508
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	3.101667e-01	0.508
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	3.101667e-01	0.508
CD28 dependent PI3K/Akt signaling	R-HSA-389357	3.101667e-01	0.508
Neuronal System	R-HSA-112316	3.121606e-01	0.506
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	3.178931e-01	0.498
Formation of the Early Elongation Complex	R-HSA-113418	3.178931e-01	0.498
HIV elongation arrest and recovery	R-HSA-167287	3.178931e-01	0.498
Pausing and recovery of HIV elongation	R-HSA-167290	3.178931e-01	0.498
FRS-mediated FGFR2 signaling	R-HSA-5654700	3.178931e-01	0.498
Signaling by Insulin receptor	R-HSA-74752	3.181229e-01	0.497
Interferon gamma signaling	R-HSA-877300	3.204644e-01	0.494
FCGR activation	R-HSA-2029481	3.222292e-01	0.492
Regulation of TP53 Activity	R-HSA-5633007	3.235236e-01	0.490
mRNA Capping	R-HSA-72086	3.255334e-01	0.487
Regulation of CDH11 Expression and Function	R-HSA-9759475	3.255334e-01	0.487
Cell surface interactions at the vascular wall	R-HSA-202733	3.276474e-01	0.485
Downregulation of ERBB2 signaling	R-HSA-8863795	3.330886e-01	0.477
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	3.330886e-01	0.477
RNA Polymerase III Transcription Initiation	R-HSA-76046	3.330886e-01	0.477
Formation of a pool of free 40S subunits	R-HSA-72689	3.345102e-01	0.476
CLEC7A (Dectin-1) signaling	R-HSA-5607764	3.385900e-01	0.470
EGFR downregulation	R-HSA-182971	3.405597e-01	0.468
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	3.405597e-01	0.468
Signaling by TGF-beta Receptor Complex	R-HSA-170834	3.426623e-01	0.465
G0 and Early G1	R-HSA-1538133	3.479475e-01	0.458
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	3.479475e-01	0.458
Diseases of mitotic cell cycle	R-HSA-9675126	3.479475e-01	0.458
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	3.479475e-01	0.458
Apoptotic cleavage of cellular proteins	R-HSA-111465	3.479475e-01	0.458
FOXO-mediated transcription	R-HSA-9614085	3.507829e-01	0.455
Transport of the SLBP independent Mature mRNA	R-HSA-159227	3.552530e-01	0.449
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	3.552530e-01	0.449
FGFR1 mutant receptor activation	R-HSA-1839124	3.552530e-01	0.449
Nuclear RNA decay	R-HSA-9930044	3.552530e-01	0.449
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	3.552530e-01	0.449
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	3.552530e-01	0.449
G alpha (s) signalling events	R-HSA-418555	3.601940e-01	0.443
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	3.624770e-01	0.441
Vpu mediated degradation of CD4	R-HSA-180534	3.624770e-01	0.441
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	3.624770e-01	0.441
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	3.624770e-01	0.441
Heme degradation	R-HSA-189483	3.624770e-01	0.441
Regulation of endogenous retroelements	R-HSA-9842860	3.628993e-01	0.440
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	3.662858e-01	0.436
Leishmania parasite growth and survival	R-HSA-9664433	3.662858e-01	0.436
Metabolism of RNA	R-HSA-8953854	3.683953e-01	0.434
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	3.696206e-01	0.432
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	3.696206e-01	0.432
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	3.696206e-01	0.432
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	3.766846e-01	0.424
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	3.766846e-01	0.424
PERK regulates gene expression	R-HSA-381042	3.766846e-01	0.424
Regulation of Apoptosis	R-HSA-169911	3.766846e-01	0.424
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	3.766846e-01	0.424
Oncogene Induced Senescence	R-HSA-2559585	3.766846e-01	0.424
GPVI-mediated activation cascade	R-HSA-114604	3.836699e-01	0.416
Vif-mediated degradation of APOBEC3G	R-HSA-180585	3.836699e-01	0.416
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	3.836699e-01	0.416
RNA Polymerase III Transcription	R-HSA-74158	3.836699e-01	0.416
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	3.836699e-01	0.416
FGFR2 mutant receptor activation	R-HSA-1839126	3.836699e-01	0.416
G1/S-Specific Transcription	R-HSA-69205	3.836699e-01	0.416
Regulation of TP53 Degradation	R-HSA-6804757	3.836699e-01	0.416
Cellular Senescence	R-HSA-2559583	3.875248e-01	0.412
Degradation of DVL	R-HSA-4641258	3.905773e-01	0.408
Degradation of AXIN	R-HSA-4641257	3.905773e-01	0.408
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	3.905773e-01	0.408
Ovarian tumor domain proteases	R-HSA-5689896	3.905773e-01	0.408
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	3.905773e-01	0.408
Metabolism of folate and pterines	R-HSA-196757	3.905773e-01	0.408
Antigen processing-Cross presentation	R-HSA-1236975	3.908275e-01	0.408
Translation	R-HSA-72766	3.943602e-01	0.404
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	4.041620e-01	0.393
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	4.041620e-01	0.393
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	4.041620e-01	0.393
NS1 Mediated Effects on Host Pathways	R-HSA-168276	4.041620e-01	0.393
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	4.041620e-01	0.393
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	4.041620e-01	0.393
Stabilization of p53	R-HSA-69541	4.041620e-01	0.393
Regulation of TP53 Expression and Degradation	R-HSA-6806003	4.041620e-01	0.393
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	4.108410e-01	0.386
HIV Transcription Elongation	R-HSA-167169	4.108410e-01	0.386
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	4.108410e-01	0.386
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	4.108410e-01	0.386
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	4.108410e-01	0.386
Diseases of Immune System	R-HSA-5260271	4.108410e-01	0.386
Diseases associated with the TLR signaling cascade	R-HSA-5602358	4.108410e-01	0.386
Negative regulation of NOTCH4 signaling	R-HSA-9604323	4.108410e-01	0.386
Regulation of RUNX3 expression and activity	R-HSA-8941858	4.108410e-01	0.386
Glycogen metabolism	R-HSA-8982491	4.108410e-01	0.386
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	4.174455e-01	0.379
Hh mutants are degraded by ERAD	R-HSA-5362768	4.174455e-01	0.379
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	4.174455e-01	0.379
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	4.239764e-01	0.373
HIV Transcription Initiation	R-HSA-167161	4.239764e-01	0.373
RNA Polymerase II Transcription Initiation	R-HSA-75953	4.239764e-01	0.373
Degradation of CRY and PER proteins	R-HSA-9932298	4.239764e-01	0.373
Degradation of GLI1 by the proteasome	R-HSA-5610780	4.239764e-01	0.373
Intra-Golgi traffic	R-HSA-6811438	4.239764e-01	0.373
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	4.239764e-01	0.373
Degradation of GLI2 by the proteasome	R-HSA-5610783	4.239764e-01	0.373
MTOR signalling	R-HSA-165159	4.304345e-01	0.366
Cytosolic tRNA aminoacylation	R-HSA-379716	4.304345e-01	0.366
Signaling by Nuclear Receptors	R-HSA-9006931	4.312278e-01	0.365
RNA Polymerase II Promoter Escape	R-HSA-73776	4.368205e-01	0.360
Hh mutants abrogate ligand secretion	R-HSA-5387390	4.368205e-01	0.360
Response of Mtb to phagocytosis	R-HSA-9637690	4.368205e-01	0.360
Proteasome assembly	R-HSA-9907900	4.431354e-01	0.353
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	4.431354e-01	0.353
Surfactant metabolism	R-HSA-5683826	4.431354e-01	0.353
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	4.493798e-01	0.347
Asymmetric localization of PCP proteins	R-HSA-4608870	4.493798e-01	0.347
Defective CFTR causes cystic fibrosis	R-HSA-5678895	4.493798e-01	0.347
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	4.493798e-01	0.347
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	4.493798e-01	0.347
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	4.493798e-01	0.347
Somitogenesis	R-HSA-9824272	4.493798e-01	0.347
DAG and IP3 signaling	R-HSA-1489509	4.493798e-01	0.347
Neutrophil degranulation	R-HSA-6798695	4.501278e-01	0.347
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	4.555546e-01	0.341
Regulation of TNFR1 signaling	R-HSA-5357905	4.555546e-01	0.341
Apoptotic execution phase	R-HSA-75153	4.555546e-01	0.341
Maternal to zygotic transition (MZT)	R-HSA-9816359	4.562001e-01	0.341
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	4.616605e-01	0.336
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	4.616605e-01	0.336
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	4.616605e-01	0.336
Transcriptional Regulation by TP53	R-HSA-3700989	4.658946e-01	0.332
G1/S Transition	R-HSA-69206	4.673223e-01	0.330
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	4.736688e-01	0.325
p53-Dependent G1 DNA Damage Response	R-HSA-69563	4.736688e-01	0.325
Platelet degranulation	R-HSA-114608	4.746623e-01	0.324
PI3K Cascade	R-HSA-109704	4.795727e-01	0.319
Activation of NF-kappaB in B cells	R-HSA-1169091	4.854107e-01	0.314
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	4.854107e-01	0.314
Hedgehog ligand biogenesis	R-HSA-5358346	4.854107e-01	0.314
Reproduction	R-HSA-1474165	4.891584e-01	0.311
Formation of RNA Pol II elongation complex	R-HSA-112382	4.911836e-01	0.309
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	4.911836e-01	0.309
Orc1 removal from chromatin	R-HSA-68949	4.911836e-01	0.309
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	4.911836e-01	0.309
Circadian clock	R-HSA-9909396	4.963127e-01	0.304
RNA Polymerase II Transcription Elongation	R-HSA-75955	4.968921e-01	0.304
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	4.968921e-01	0.304
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	4.968921e-01	0.304
Regulation of PTEN stability and activity	R-HSA-8948751	4.968921e-01	0.304
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	4.998660e-01	0.301
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	5.025369e-01	0.299
Glucuronidation	R-HSA-156588	5.025369e-01	0.299
Generic Transcription Pathway	R-HSA-212436	5.045587e-01	0.297
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	5.081187e-01	0.294
Signaling by NOTCH3	R-HSA-9012852	5.081187e-01	0.294
NRAGE signals death through JNK	R-HSA-193648	5.136382e-01	0.289
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	5.136382e-01	0.289
TNF signaling	R-HSA-75893	5.136382e-01	0.289
Estrogen-dependent gene expression	R-HSA-9018519	5.139188e-01	0.289
Integration of energy metabolism	R-HSA-163685	5.139188e-01	0.289
Dectin-2 family	R-HSA-5621480	5.190961e-01	0.285
IRS-mediated signalling	R-HSA-112399	5.190961e-01	0.285
Synthesis of PA	R-HSA-1483166	5.190961e-01	0.285
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	5.244931e-01	0.280
Deadenylation-dependent mRNA decay	R-HSA-429914	5.298298e-01	0.276
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	5.298298e-01	0.276
RAB geranylgeranylation	R-HSA-8873719	5.351070e-01	0.272
Metabolism of polyamines	R-HSA-351202	5.351070e-01	0.272
tRNA Aminoacylation	R-HSA-379724	5.351070e-01	0.272
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	5.378807e-01	0.269
Epigenetic regulation of gene expression	R-HSA-212165	5.396388e-01	0.268
IRS-related events triggered by IGF1R	R-HSA-2428928	5.403253e-01	0.267
Viral Messenger RNA Synthesis	R-HSA-168325	5.403253e-01	0.267
Regulation of RUNX2 expression and activity	R-HSA-8939902	5.403253e-01	0.267
Formation of paraxial mesoderm	R-HSA-9793380	5.403253e-01	0.267
tRNA processing in the nucleus	R-HSA-6784531	5.454853e-01	0.263
NCAM signaling for neurite out-growth	R-HSA-375165	5.454853e-01	0.263
Mitochondrial protein import	R-HSA-1268020	5.454853e-01	0.263
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	5.454853e-01	0.263
Heme signaling	R-HSA-9707616	5.454853e-01	0.263
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	5.454853e-01	0.263
rRNA modification in the nucleus and cytosol	R-HSA-6790901	5.505877e-01	0.259
G1/S DNA Damage Checkpoints	R-HSA-69615	5.505877e-01	0.259
Metabolism of proteins	R-HSA-392499	5.577098e-01	0.254
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	5.606223e-01	0.251
Cellular response to hypoxia	R-HSA-1234174	5.606223e-01	0.251
RNA Polymerase II Transcription	R-HSA-73857	5.620643e-01	0.250
KEAP1-NFE2L2 pathway	R-HSA-9755511	5.674817e-01	0.246
DNA Double Strand Break Response	R-HSA-5693606	5.704340e-01	0.244
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	5.706857e-01	0.244
Transcription of the HIV genome	R-HSA-167172	5.752578e-01	0.240
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	5.752578e-01	0.240
Fatty acyl-CoA biosynthesis	R-HSA-75105	5.847445e-01	0.233
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	5.847445e-01	0.233
Cyclin E associated events during G1/S transition	R-HSA-69202	5.847445e-01	0.233
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	5.847445e-01	0.233
Regulation of mitotic cell cycle	R-HSA-453276	5.894085e-01	0.230
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	5.894085e-01	0.230
Hedgehog 'on' state	R-HSA-5632684	5.894085e-01	0.230
Metabolism of porphyrins	R-HSA-189445	5.894085e-01	0.230
trans-Golgi Network Vesicle Budding	R-HSA-199992	5.940204e-01	0.226
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	5.940204e-01	0.226
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	5.940204e-01	0.226
Signaling by TGFB family members	R-HSA-9006936	5.957007e-01	0.225
Switching of origins to a post-replicative state	R-HSA-69052	5.985808e-01	0.223
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	5.985808e-01	0.223
Regulation of T cell activation by CD28 family	R-HSA-388841	6.013917e-01	0.221
Apoptosis	R-HSA-109581	6.017826e-01	0.221
RNA Polymerase II Pre-transcription Events	R-HSA-674695	6.030902e-01	0.220
Non-integrin membrane-ECM interactions	R-HSA-3000171	6.075493e-01	0.216
UCH proteinases	R-HSA-5689603	6.119585e-01	0.213
Nuclear Receptor transcription pathway	R-HSA-383280	6.206298e-01	0.207
Interleukin-10 signaling	R-HSA-6783783	6.206298e-01	0.207
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	6.206298e-01	0.207
G alpha (12/13) signalling events	R-HSA-416482	6.206298e-01	0.207
ABC transporter disorders	R-HSA-5619084	6.206298e-01	0.207
PCP/CE pathway	R-HSA-4086400	6.206298e-01	0.207
Integrin cell surface interactions	R-HSA-216083	6.206298e-01	0.207
Post-translational protein modification	R-HSA-597592	6.206972e-01	0.207
Cellular response to chemical stress	R-HSA-9711123	6.300956e-01	0.201
C-type lectin receptors (CLRs)	R-HSA-5621481	6.311620e-01	0.200
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	6.332766e-01	0.198
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	6.373983e-01	0.196
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	6.373983e-01	0.196
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	6.414739e-01	0.193
Cytoprotection by HMOX1	R-HSA-9707564	6.414739e-01	0.193
Oncogenic MAPK signaling	R-HSA-6802957	6.494891e-01	0.187
MAPK6/MAPK4 signaling	R-HSA-5687128	6.494891e-01	0.187
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	6.534296e-01	0.185
Amplification of signal from the kinetochores	R-HSA-141424	6.534296e-01	0.185
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	6.534296e-01	0.185
Influenza Infection	R-HSA-168255	6.534361e-01	0.185
TCF dependent signaling in response to WNT	R-HSA-201681	6.641678e-01	0.178
Downstream TCR signaling	R-HSA-202424	6.724808e-01	0.172
Eukaryotic Translation Elongation	R-HSA-156842	6.834078e-01	0.165
Assembly of the pre-replicative complex	R-HSA-68867	6.869690e-01	0.163
Mitochondrial protein degradation	R-HSA-9837999	6.904903e-01	0.161
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	6.974152e-01	0.157
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	7.008197e-01	0.154
Transcriptional regulation by RUNX3	R-HSA-8878159	7.041860e-01	0.152
Mitotic Spindle Checkpoint	R-HSA-69618	7.140607e-01	0.146
ABC-family proteins mediated transport	R-HSA-382556	7.140607e-01	0.146
Interleukin-1 signaling	R-HSA-9020702	7.172789e-01	0.144
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	7.204610e-01	0.142
PI Metabolism	R-HSA-1483255	7.204610e-01	0.142
Programmed Cell Death	R-HSA-5357801	7.207755e-01	0.142
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	7.328373e-01	0.135
SARS-CoV-1-host interactions	R-HSA-9692914	7.358452e-01	0.133
Gene expression (Transcription)	R-HSA-74160	7.359591e-01	0.133
Synthesis of DNA	R-HSA-69239	7.388195e-01	0.131
DNA Replication Pre-Initiation	R-HSA-69002	7.446685e-01	0.128
Inositol phosphate metabolism	R-HSA-1483249	7.531987e-01	0.123
Neddylation	R-HSA-8951664	7.552664e-01	0.122
Extracellular matrix organization	R-HSA-1474244	7.569921e-01	0.121
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	7.587274e-01	0.120
SARS-CoV-2-host interactions	R-HSA-9705683	7.691706e-01	0.114
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	7.711002e-01	0.113
Mitochondrial biogenesis	R-HSA-1592230	7.720162e-01	0.112
Homology Directed Repair	R-HSA-5693538	7.745852e-01	0.111
Mitotic Prophase	R-HSA-68875	7.796374e-01	0.108
Chromatin modifying enzymes	R-HSA-3247509	7.805395e-01	0.108
Cellular response to heat stress	R-HSA-3371556	7.821210e-01	0.107
Infection with Mycobacterium tuberculosis	R-HSA-9635486	7.821210e-01	0.107
Nuclear events mediated by NFE2L2	R-HSA-9759194	7.821210e-01	0.107
Formation of the cornified envelope	R-HSA-6809371	7.894062e-01	0.103
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	7.941279e-01	0.100
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	7.941279e-01	0.100
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	7.941279e-01	0.100
G2/M Checkpoints	R-HSA-69481	7.987443e-01	0.098
Chromatin organization	R-HSA-4839726	8.068475e-01	0.093
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	8.098399e-01	0.092
Degradation of the extracellular matrix	R-HSA-1474228	8.119849e-01	0.090
Deubiquitination	R-HSA-5688426	8.165652e-01	0.088
Cell Cycle Checkpoints	R-HSA-69620	8.212592e-01	0.086
Beta-catenin independent WNT signaling	R-HSA-3858494	8.223542e-01	0.085
Ribosome-associated quality control	R-HSA-9948299	8.263409e-01	0.083
Class I MHC mediated antigen processing & presentation	R-HSA-983169	8.345157e-01	0.079
Late Phase of HIV Life Cycle	R-HSA-162599	8.359226e-01	0.078
FCERI mediated NF-kB activation	R-HSA-2871837	8.396064e-01	0.076
Bacterial Infection Pathways	R-HSA-9824439	8.429880e-01	0.074
S Phase	R-HSA-69242	8.467290e-01	0.072
Gastrulation	R-HSA-9758941	8.484599e-01	0.071
Interleukin-1 family signaling	R-HSA-446652	8.535369e-01	0.069
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	8.551045e-01	0.068
DNA Replication	R-HSA-69306	8.551914e-01	0.068
Protein localization	R-HSA-9609507	8.551914e-01	0.068
DNA Double-Strand Break Repair	R-HSA-5693532	8.551914e-01	0.068
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	8.568273e-01	0.067
Influenza Viral RNA Transcription and Replication	R-HSA-168273	8.584448e-01	0.066
PPARA activates gene expression	R-HSA-1989781	8.584448e-01	0.066
HIV Life Cycle	R-HSA-162587	8.616255e-01	0.065
HCMV Late Events	R-HSA-9610379	8.616255e-01	0.065
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	8.616255e-01	0.065
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	8.616255e-01	0.065
Phospholipid metabolism	R-HSA-1483257	8.709075e-01	0.060
Signaling by WNT	R-HSA-195721	8.743233e-01	0.058
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	8.819860e-01	0.055
tRNA processing	R-HSA-72306	8.819860e-01	0.055
Regulation of PD-L1(CD274) expression	R-HSA-9909648	8.846404e-01	0.053
Ub-specific processing proteases	R-HSA-5689880	8.859452e-01	0.053
SARS-CoV-1 Infection	R-HSA-9678108	8.885110e-01	0.051
Respiratory electron transport	R-HSA-611105	8.922524e-01	0.050
rRNA processing in the nucleus and cytosol	R-HSA-8868773	9.038450e-01	0.044
Toll-like Receptor Cascades	R-HSA-168898	9.070744e-01	0.042
Co-inhibition by PD-1	R-HSA-389948	9.161296e-01	0.038
Glycerophospholipid biosynthesis	R-HSA-1483206	9.189486e-01	0.037
SARS-CoV-2 Infection	R-HSA-9694516	9.210246e-01	0.036
Keratinization	R-HSA-6805567	9.225611e-01	0.035
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.411096e-01	0.026
rRNA processing	R-HSA-72312	9.424392e-01	0.026
Phase II - Conjugation of compounds	R-HSA-156580	9.468620e-01	0.024
GPCR downstream signalling	R-HSA-388396	9.470945e-01	0.024
Disorders of transmembrane transporters	R-HSA-5619115	9.515041e-01	0.022
G alpha (q) signalling events	R-HSA-416476	9.600723e-01	0.018
Signaling by GPCR	R-HSA-372790	9.714046e-01	0.013
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.834913e-01	0.007
DNA Repair	R-HSA-73894	9.867328e-01	0.006
Metabolism of vitamins and cofactors	R-HSA-196854	9.873299e-01	0.006
Fatty acid metabolism	R-HSA-8978868	9.923715e-01	0.003
Diseases of metabolism	R-HSA-5668914	9.939455e-01	0.003
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.956212e-01	0.002
Biological oxidations	R-HSA-211859	9.980114e-01	0.001
Sensory Perception	R-HSA-9709957	9.988074e-01	0.001
Metabolism of amino acids and derivatives	R-HSA-71291	9.993437e-01	0.000
Transport of small molecules	R-HSA-382551	9.998841e-01	0.000
Metabolism of lipids	R-HSA-556833	9.999766e-01	0.000
Metabolism	R-HSA-1430728	1.000000e+00	0.000

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
Axon guidance	R-HSA-422475	8.869482e-10	9.052
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	2.365636e-09	8.626
Nervous system development	R-HSA-9675108	3.265700e-09	8.486
Developmental Biology	R-HSA-1266738	2.425232e-08	7.615
Cell-Cell communication	R-HSA-1500931	4.432692e-08	7.353
Regulation of CDH1 Function	R-HSA-9764561	5.909858e-08	7.228
Cell junction organization	R-HSA-446728	2.503958e-07	6.601
Adherens junctions interactions	R-HSA-418990	5.006742e-07	6.300
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	5.702766e-07	6.244
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	1.811892e-06	5.742
Regulation of CDH1 Expression and Function	R-HSA-9764265	1.811892e-06	5.742
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	1.910307e-06	5.719
Programmed Cell Death	R-HSA-5357801	1.575262e-06	5.803
Cell-cell junction organization	R-HSA-421270	2.256084e-06	5.647
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	2.193248e-06	5.659
Activation of BAD and translocation to mitochondria	R-HSA-111447	2.641600e-06	5.578
EPH-Ephrin signaling	R-HSA-2682334	2.412403e-06	5.618
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	2.641600e-06	5.578
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	4.122897e-06	5.385
Non-integrin membrane-ECM interactions	R-HSA-3000171	4.683819e-06	5.329
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	5.668210e-06	5.247
Apoptosis	R-HSA-109581	6.069701e-06	5.217
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	8.241618e-06	5.084
Signaling by ALK in cancer	R-HSA-9700206	8.241618e-06	5.084
Signal Transduction	R-HSA-162582	8.473476e-06	5.072
Post-chaperonin tubulin folding pathway	R-HSA-389977	9.878946e-06	5.005
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	1.201030e-05	4.920
VEGFA-VEGFR2 Pathway	R-HSA-4420097	1.551907e-05	4.809
Regulation of localization of FOXO transcription factors	R-HSA-9614399	2.002644e-05	4.698
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	2.232257e-05	4.651
SARS-CoV-2-host interactions	R-HSA-9705683	2.303189e-05	4.638
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	2.482041e-05	4.605
Gap junction trafficking	R-HSA-190828	2.773937e-05	4.557
Signaling by VEGF	R-HSA-194138	2.925195e-05	4.534
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	3.779950e-05	4.423
Recycling pathway of L1	R-HSA-437239	3.779950e-05	4.423
G2/M DNA damage checkpoint	R-HSA-69473	3.998853e-05	4.398
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	4.243689e-05	4.372
Gap junction trafficking and regulation	R-HSA-157858	4.599574e-05	4.337
Signaling by Erythropoietin	R-HSA-9006335	4.863362e-05	4.313
Disease	R-HSA-1643685	4.894744e-05	4.310
Membrane Trafficking	R-HSA-199991	5.390388e-05	4.268
Activation of BH3-only proteins	R-HSA-114452	5.549733e-05	4.256
SARS-CoV-1-host interactions	R-HSA-9692914	5.652651e-05	4.248
Downstream signal transduction	R-HSA-186763	6.308589e-05	4.200
Cell-extracellular matrix interactions	R-HSA-446353	6.509372e-05	4.186
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	6.509372e-05	4.186
MITF-M-regulated melanocyte development	R-HSA-9730414	6.302027e-05	4.201
SARS-CoV-1 Infection	R-HSA-9678108	6.675285e-05	4.176
Intrinsic Pathway for Apoptosis	R-HSA-109606	8.652135e-05	4.063
Selective autophagy	R-HSA-9663891	1.129863e-04	3.947
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	1.403296e-04	3.853
Erythropoietin activates STAT5	R-HSA-9027283	1.474940e-04	3.831
Autophagy	R-HSA-9612973	1.508099e-04	3.822
Aggrephagy	R-HSA-9646399	1.910297e-04	3.719
Cellular responses to stress	R-HSA-2262752	1.961203e-04	3.707
G2/M Checkpoints	R-HSA-69481	1.991668e-04	3.701
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	2.334201e-04	3.632
Immune System	R-HSA-168256	2.203167e-04	3.657
Infectious disease	R-HSA-5663205	2.310777e-04	3.636
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	2.479335e-04	3.606
SARS-CoV-2 Infection	R-HSA-9694516	2.507453e-04	3.601
Formation of annular gap junctions	R-HSA-196025	2.649846e-04	3.577
Signaling by SCF-KIT	R-HSA-1433557	2.774355e-04	3.557
Developmental Lineages of the Mammary Gland	R-HSA-9924644	2.857689e-04	3.544
EPHB-mediated forward signaling	R-HSA-3928662	3.030435e-04	3.518
Developmental Cell Lineages	R-HSA-9734767	3.343931e-04	3.476
Vesicle-mediated transport	R-HSA-5653656	3.389507e-04	3.470
Gap junction degradation	R-HSA-190873	3.412611e-04	3.467
Leishmania phagocytosis	R-HSA-9664417	3.872923e-04	3.412
Parasite infection	R-HSA-9664407	3.872923e-04	3.412
FCGR3A-mediated phagocytosis	R-HSA-9664422	3.872923e-04	3.412
Macroautophagy	R-HSA-1632852	4.037355e-04	3.394
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	4.061582e-04	3.391
G2/M Transition	R-HSA-69275	4.945126e-04	3.306
Cellular responses to stimuli	R-HSA-8953897	4.656560e-04	3.332
EPHA-mediated growth cone collapse	R-HSA-3928663	5.257191e-04	3.279
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	5.257191e-04	3.279
Mitotic G2-G2/M phases	R-HSA-453274	5.297430e-04	3.276
Interleukin-2 signaling	R-HSA-9020558	5.332534e-04	3.273
Activation of AMPK downstream of NMDARs	R-HSA-9619483	5.873824e-04	3.231
Leishmania infection	R-HSA-9658195	5.565700e-04	3.254
Parasitic Infection Pathways	R-HSA-9824443	5.565700e-04	3.254
MITF-M-dependent gene expression	R-HSA-9856651	6.016198e-04	3.221
Signaling by CSF3 (G-CSF)	R-HSA-9674555	6.540124e-04	3.184
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	6.540124e-04	3.184
Translation initiation complex formation	R-HSA-72649	6.687547e-04	3.175
Ribosomal scanning and start codon recognition	R-HSA-72702	7.701638e-04	3.113
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	7.794926e-04	3.108
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	8.030480e-04	3.095
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	8.826356e-04	3.054
Cytokine Signaling in Immune system	R-HSA-1280215	9.915471e-04	3.004
Signaling by ERBB2	R-HSA-1227986	1.006905e-03	2.997
Protein folding	R-HSA-391251	1.007679e-03	2.997
Striated Muscle Contraction	R-HSA-390522	1.069338e-03	2.971
Signaling by PDGF	R-HSA-186797	1.143721e-03	2.942
Cell Cycle	R-HSA-1640170	1.216258e-03	2.915
Semaphorin interactions	R-HSA-373755	1.217071e-03	2.915
Sema3A PAK dependent Axon repulsion	R-HSA-399954	1.280435e-03	2.893
HSF1 activation	R-HSA-3371511	1.392198e-03	2.856
STAT6-mediated induction of chemokines	R-HSA-3249367	1.448385e-03	2.839
Platelet activation, signaling and aggregation	R-HSA-76002	1.676466e-03	2.776
Viral Infection Pathways	R-HSA-9824446	1.864615e-03	2.729
SARS-CoV Infections	R-HSA-9679506	1.879552e-03	2.726
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	1.935297e-03	2.713
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	1.940506e-03	2.712
trans-Golgi Network Vesicle Budding	R-HSA-199992	2.042984e-03	2.690
FLT3 Signaling	R-HSA-9607240	2.072067e-03	2.684
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	2.398682e-03	2.620
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	2.274557e-03	2.643
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	2.231256e-03	2.651
Chaperone Mediated Autophagy	R-HSA-9613829	2.199635e-03	2.658
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	2.274557e-03	2.643
Signaling by FGFR in disease	R-HSA-1226099	2.271395e-03	2.644
Transport of connexons to the plasma membrane	R-HSA-190872	2.199635e-03	2.658
Signaling by FGFR1 in disease	R-HSA-5655302	2.231256e-03	2.651
Regulation of signaling by CBL	R-HSA-912631	2.479265e-03	2.606
Regulation of MITF-M dependent genes involved in invasion	R-HSA-9854909	2.798205e-03	2.553
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	2.952475e-03	2.530
TP53 Regulates Metabolic Genes	R-HSA-5628897	3.119411e-03	2.506
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	3.147508e-03	2.502
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	3.154936e-03	2.501
Cap-dependent Translation Initiation	R-HSA-72737	3.363034e-03	2.473
Eukaryotic Translation Initiation	R-HSA-72613	3.363034e-03	2.473
L1CAM interactions	R-HSA-373760	3.363034e-03	2.473
Signaling by ROBO receptors	R-HSA-376176	3.407593e-03	2.468
Hemostasis	R-HSA-109582	3.525061e-03	2.453
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	3.587871e-03	2.445
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	3.628586e-03	2.440
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	4.202629e-03	2.376
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	3.813028e-03	2.419
MHC class II antigen presentation	R-HSA-2132295	4.328348e-03	2.364
Signaling by KIT in disease	R-HSA-9669938	3.813028e-03	2.419
Growth hormone receptor signaling	R-HSA-982772	4.202629e-03	2.376
Post NMDA receptor activation events	R-HSA-438064	4.421258e-03	2.354
Muscle contraction	R-HSA-397014	4.424019e-03	2.354
STAT5 Activation	R-HSA-9645135	4.559520e-03	2.341
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	4.559520e-03	2.341
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	4.615555e-03	2.336
Golgi Associated Vesicle Biogenesis	R-HSA-432722	4.842839e-03	2.315
Smooth Muscle Contraction	R-HSA-445355	4.842839e-03	2.315
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	5.417894e-03	2.266
Signaling by Interleukins	R-HSA-449147	5.419920e-03	2.266
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	5.456353e-03	2.263
Uptake and function of diphtheria toxin	R-HSA-5336415	5.588735e-03	2.253
Extracellular matrix organization	R-HSA-1474244	5.808334e-03	2.236
Metabolism of RNA	R-HSA-8953854	6.566841e-03	2.183
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	6.713996e-03	2.173
ALK mutants bind TKIs	R-HSA-9700645	7.933103e-03	2.101
Impaired BRCA2 binding to RAD51	R-HSA-9709570	7.042995e-03	2.152
Formation of a pool of free 40S subunits	R-HSA-72689	6.652054e-03	2.177
Ribosome-associated quality control	R-HSA-9948299	7.736549e-03	2.111
Interleukin-21 signaling	R-HSA-9020958	7.933103e-03	2.101
Interleukin-9 signaling	R-HSA-8985947	6.713996e-03	2.173
Adaptive Immune System	R-HSA-1280218	7.088750e-03	2.149
Respiratory syncytial virus genome replication	R-HSA-9834752	7.933103e-03	2.101
Signaling by Hedgehog	R-HSA-5358351	7.736549e-03	2.111
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	8.171570e-03	2.088
Loss of Nlp from mitotic centrosomes	R-HSA-380259	8.171570e-03	2.088
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	8.618751e-03	2.065
Drug resistance of PDGFR mutants	R-HSA-9674415	1.093189e-02	1.961
PDGFR mutants bind TKIs	R-HSA-9674428	1.093189e-02	1.961
Sunitinib-resistant PDGFR mutants	R-HSA-9674401	1.093189e-02	1.961
Regorafenib-resistant PDGFR mutants	R-HSA-9674403	1.093189e-02	1.961
Sorafenib-resistant PDGFR mutants	R-HSA-9674404	1.093189e-02	1.961
Imatinib-resistant PDGFR mutants	R-HSA-9674396	1.093189e-02	1.961
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	9.243895e-03	2.034
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	9.243895e-03	2.034
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	1.064424e-02	1.973
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	1.079439e-02	1.967
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	8.980033e-03	2.047
AURKA Activation by TPX2	R-HSA-8854518	9.403134e-03	2.027
mRNA Splicing - Major Pathway	R-HSA-72163	9.711226e-03	2.013
Integrin signaling	R-HSA-354192	9.439198e-03	2.025
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	9.439198e-03	2.025
Clathrin-mediated endocytosis	R-HSA-8856828	9.213440e-03	2.036
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	1.079439e-02	1.967
PECAM1 interactions	R-HSA-210990	1.064424e-02	1.973
Signaling by Leptin	R-HSA-2586552	9.243895e-03	2.034
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	9.243895e-03	2.034
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	1.079439e-02	1.967
Activation of ATR in response to replication stress	R-HSA-176187	9.439198e-03	2.025
Gap junction assembly	R-HSA-190861	1.079439e-02	1.967
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	9.439198e-03	2.025
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	1.079439e-02	1.967
Apoptotic cleavage of cellular proteins	R-HSA-111465	8.801207e-03	2.055
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	1.151198e-02	1.939
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	1.179177e-02	1.928
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	1.179177e-02	1.928
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	1.213206e-02	1.916
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	1.213206e-02	1.916
RET signaling	R-HSA-8853659	1.225645e-02	1.912
Cell Cycle Checkpoints	R-HSA-69620	1.236646e-02	1.908
Nonsense-Mediated Decay (NMD)	R-HSA-927802	1.246858e-02	1.904
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	1.246858e-02	1.904
mRNA Splicing	R-HSA-72172	1.251506e-02	1.903
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.273030e-02	1.895
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	1.302797e-02	1.885
Signaling by NOTCH4	R-HSA-9013694	1.325941e-02	1.877
Innate Immune System	R-HSA-168249	1.337115e-02	1.874
Cell Cycle, Mitotic	R-HSA-69278	1.347793e-02	1.870
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	1.370528e-02	1.863
Interleukin-15 signaling	R-HSA-8983432	1.370528e-02	1.863
Centrosome maturation	R-HSA-380287	1.380234e-02	1.860
MET promotes cell motility	R-HSA-8875878	1.382666e-02	1.859
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	1.382666e-02	1.859
Interferon Signaling	R-HSA-913531	1.451969e-02	1.838
Frs2-mediated activation	R-HSA-170968	1.536189e-02	1.814
Interleukin-2 family signaling	R-HSA-451927	1.550606e-02	1.809
TICAM1 deficiency - HSE	R-HSA-5602566	2.174494e-02	1.663
Erythropoietin activates RAS	R-HSA-9027284	1.891733e-02	1.723
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	2.081228e-02	1.682
Platelet Aggregation (Plug Formation)	R-HSA-76009	2.120632e-02	1.674
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	1.883096e-02	1.725
Signaling by FGFR4 in disease	R-HSA-5655291	1.709989e-02	1.767
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	1.709989e-02	1.767
VEGFR2 mediated vascular permeability	R-HSA-5218920	1.638696e-02	1.786
MAP2K and MAPK activation	R-HSA-5674135	1.729544e-02	1.762
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	2.081228e-02	1.682
WNT5A-dependent internalization of FZD4	R-HSA-5099900	2.081228e-02	1.682
Signaling by RAF1 mutants	R-HSA-9656223	1.729544e-02	1.762
Oncogenic MAPK signaling	R-HSA-6802957	2.001544e-02	1.699
Regulation of KIT signaling	R-HSA-1433559	1.709989e-02	1.767
Signaling by FGFR2	R-HSA-5654738	1.672823e-02	1.777
Cellular response to heat stress	R-HSA-3371556	1.734448e-02	1.761
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	2.047205e-02	1.689
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	1.932854e-02	1.714
Prolonged ERK activation events	R-HSA-169893	2.081228e-02	1.682
Protein methylation	R-HSA-8876725	1.891733e-02	1.723
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	1.709989e-02	1.767
Prolactin receptor signaling	R-HSA-1170546	1.709989e-02	1.767
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	2.107704e-02	1.676
RAF/MAP kinase cascade	R-HSA-5673001	2.175342e-02	1.662
PKR-mediated signaling	R-HSA-9833482	1.672823e-02	1.777
Chaperonin-mediated protein folding	R-HSA-390466	2.216581e-02	1.654
Signaling downstream of RAS mutants	R-HSA-9649948	2.225345e-02	1.653
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	2.225345e-02	1.653
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	2.225345e-02	1.653
Signaling by RAS mutants	R-HSA-6802949	2.225345e-02	1.653
Apoptotic execution phase	R-HSA-75153	2.225345e-02	1.653
Diseases of DNA repair	R-HSA-9675135	2.225345e-02	1.653
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	2.278286e-02	1.642
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	2.278286e-02	1.642
Peptide chain elongation	R-HSA-156902	2.291273e-02	1.640
Influenza Infection	R-HSA-168255	2.299981e-02	1.638
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	2.332838e-02	1.632
MAPK1/MAPK3 signaling	R-HSA-5684996	2.442747e-02	1.612
Intraflagellar transport	R-HSA-5620924	2.443109e-02	1.612
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	2.445219e-02	1.612
Constitutive Signaling by EGFRvIII	R-HSA-5637810	2.482720e-02	1.605
Signaling by EGFRvIII in Cancer	R-HSA-5637812	2.482720e-02	1.605
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	2.482720e-02	1.605
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	2.518582e-02	1.599
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	2.524483e-02	1.598
Degradation of CDH1	R-HSA-9766229	2.556157e-02	1.592
Signaling by FGFR2 in disease	R-HSA-5655253	2.671980e-02	1.573
Eukaryotic Translation Elongation	R-HSA-156842	2.687626e-02	1.571
Synaptic adhesion-like molecules	R-HSA-8849932	2.694347e-02	1.570
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	2.694347e-02	1.570
Signaling by ERBB2 ECD mutants	R-HSA-9665348	2.694347e-02	1.570
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	2.694347e-02	1.570
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	2.694347e-02	1.570
FCGR activation	R-HSA-2029481	2.771513e-02	1.557
rRNA processing in the nucleus and cytosol	R-HSA-8868773	2.774966e-02	1.557
Hedgehog ligand biogenesis	R-HSA-5358346	2.790573e-02	1.554
TRAF3 deficiency - HSE	R-HSA-5602571	3.244044e-02	1.489
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	R-HSA-5619050	3.244044e-02	1.489
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	4.301965e-02	1.366
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	4.301965e-02	1.366
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	4.301965e-02	1.366
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	4.301965e-02	1.366
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	4.301965e-02	1.366
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	4.301965e-02	1.366
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	4.301965e-02	1.366
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	4.301965e-02	1.366
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	4.301965e-02	1.366
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	4.301965e-02	1.366
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	4.301965e-02	1.366
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	3.370606e-02	1.472
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	3.370606e-02	1.472
FGFR2 alternative splicing	R-HSA-6803529	3.854196e-02	1.414
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	3.854196e-02	1.414
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	2.943944e-02	1.531
Viral mRNA Translation	R-HSA-192823	3.797373e-02	1.421
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	3.981493e-02	1.400
Neutrophil degranulation	R-HSA-6798695	3.954566e-02	1.403
Mitochondrial protein import	R-HSA-1268020	4.275935e-02	1.369
Co-inhibition by CTLA4	R-HSA-389513	3.138466e-02	1.503
Eukaryotic Translation Termination	R-HSA-72764	3.032495e-02	1.518
Signaling by FGFR	R-HSA-190236	3.307534e-02	1.480
STING mediated induction of host immune responses	R-HSA-1834941	2.912988e-02	1.536
Listeria monocytogenes entry into host cells	R-HSA-8876384	3.609239e-02	1.443
Mitotic Prometaphase	R-HSA-68877	3.064983e-02	1.514
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	2.912988e-02	1.536
Cilium Assembly	R-HSA-5617833	2.888694e-02	1.539
O2/CO2 exchange in erythrocytes	R-HSA-1480926	2.912988e-02	1.536
Selenocysteine synthesis	R-HSA-2408557	3.596709e-02	1.444
Activation, myristolyation of BID and translocation to mitochondria	R-HSA-75108	4.301965e-02	1.366
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	2.912988e-02	1.536
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	4.105312e-02	1.387
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	3.900074e-02	1.409
Organelle biogenesis and maintenance	R-HSA-1852241	3.533691e-02	1.452
Hedgehog 'off' state	R-HSA-5610787	3.498743e-02	1.456
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	3.162923e-02	1.500
COPI-mediated anterograde transport	R-HSA-6807878	3.122608e-02	1.505
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	3.503353e-02	1.456
Kinesins	R-HSA-983189	3.981493e-02	1.400
Syndecan interactions	R-HSA-3000170	4.105312e-02	1.387
ER to Golgi Anterograde Transport	R-HSA-199977	3.657446e-02	1.437
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	3.370606e-02	1.472
Potential therapeutics for SARS	R-HSA-9679191	3.901102e-02	1.409
Nephrin family interactions	R-HSA-373753	3.138466e-02	1.503
Formation of definitive endoderm	R-HSA-9823730	3.138466e-02	1.503
Interleukin-20 family signaling	R-HSA-8854691	4.105312e-02	1.387
FOXO-mediated transcription	R-HSA-9614085	3.402352e-02	1.468
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	4.326677e-02	1.364
Influenza Viral RNA Transcription and Replication	R-HSA-168273	4.328782e-02	1.364
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	4.362425e-02	1.360
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	4.362425e-02	1.360
Neurodegenerative Diseases	R-HSA-8863678	4.362425e-02	1.360
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	4.362425e-02	1.360
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	4.420582e-02	1.355
VEGFR2 mediated cell proliferation	R-HSA-5218921	4.625375e-02	1.335
Interleukin-7 signaling	R-HSA-1266695	4.625375e-02	1.335
ATP-dependent chromatin remodelers	R-HSA-9932444	4.625375e-02	1.335
SWI/SNF chromatin remodelers	R-HSA-9932451	4.625375e-02	1.335
TCR signaling	R-HSA-202403	4.663216e-02	1.331
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	4.841985e-02	1.315
Signaling by EGFR in Cancer	R-HSA-1643713	4.894006e-02	1.310
Signaling by FLT3 fusion proteins	R-HSA-9703465	4.894006e-02	1.310
HDR through Homologous Recombination (HRR)	R-HSA-5685942	5.058250e-02	1.296
MAPK family signaling cascades	R-HSA-5683057	5.110108e-02	1.292
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	5.168164e-02	1.287
Interaction between L1 and Ankyrins	R-HSA-445095	5.168164e-02	1.287
Cristae formation	R-HSA-8949613	5.168164e-02	1.287
Signaling by FGFR3 in disease	R-HSA-5655332	5.168164e-02	1.287
Signaling by NTRK2 (TRKB)	R-HSA-9006115	5.168164e-02	1.287
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	5.168164e-02	1.287
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	5.222510e-02	1.282
Activated NTRK3 signals through PLCG1	R-HSA-9034793	5.348384e-02	1.272
PLC-gamma1 signalling	R-HSA-167021	5.348384e-02	1.272
Axonal growth stimulation	R-HSA-209563	5.348384e-02	1.272
MET interacts with TNS proteins	R-HSA-8875513	5.348384e-02	1.272
Role of phospholipids in phagocytosis	R-HSA-2029485	5.503562e-02	1.259
Regulation of CDH1 Gene Transcription	R-HSA-9764560	5.558688e-02	1.255
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	5.558688e-02	1.255
Cargo trafficking to the periciliary membrane	R-HSA-5620920	5.730569e-02	1.242
Downstream signaling of activated FGFR3	R-HSA-5654708	5.732455e-02	1.242
Signaling by ERBB2 KD Mutants	R-HSA-9664565	5.732455e-02	1.242
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	5.904954e-02	1.229
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	5.904954e-02	1.229
DAP12 signaling	R-HSA-2424491	6.022294e-02	1.220
Downstream signaling of activated FGFR4	R-HSA-5654716	6.022294e-02	1.220
Signaling by ERBB2 in Cancer	R-HSA-1227990	6.022294e-02	1.220
Downregulation of ERBB2 signaling	R-HSA-8863795	6.022294e-02	1.220
Switching of origins to a post-replicative state	R-HSA-69052	6.081823e-02	1.216
rRNA processing	R-HSA-72312	6.102022e-02	1.215
Translation	R-HSA-72766	6.191625e-02	1.208
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	6.202835e-02	1.207
Leishmania parasite growth and survival	R-HSA-9664433	6.202835e-02	1.207
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	6.383425e-02	1.195
Activated NTRK2 signals through PLCG1	R-HSA-9026527	6.383425e-02	1.195
Inhibition of TSC complex formation by PKB	R-HSA-165181	6.383425e-02	1.195
PLCG1 events in ERBB2 signaling	R-HSA-1251932	6.383425e-02	1.195
AKT-mediated inactivation of FOXO1A	R-HSA-211163	6.383425e-02	1.195
NADE modulates death signalling	R-HSA-205025	6.383425e-02	1.195
FLT3 signaling through SRC family kinases	R-HSA-9706374	6.383425e-02	1.195
ISG15 antiviral mechanism	R-HSA-1169408	6.442929e-02	1.191
Interleukin-12 signaling	R-HSA-9020591	6.627125e-02	1.179
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	8.419862e-02	1.075
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	8.419862e-02	1.075
Phosphorylation of Emi1	R-HSA-176417	8.419862e-02	1.075
TRIF-mediated programmed cell death	R-HSA-2562578	1.041225e-01	0.982
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	1.041225e-01	0.982
Disinhibition of SNARE formation	R-HSA-114516	1.041225e-01	0.982
EGFR interacts with phospholipase C-gamma	R-HSA-212718	1.139221e-01	0.943
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	1.139221e-01	0.943
MET receptor recycling	R-HSA-8875656	1.139221e-01	0.943
Lipophagy	R-HSA-9613354	1.236152e-01	0.908
AKT phosphorylates targets in the nucleus	R-HSA-198693	1.236152e-01	0.908
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	1.332029e-01	0.875
MET activates RAP1 and RAC1	R-HSA-8875555	1.332029e-01	0.875
Folding of actin by CCT/TriC	R-HSA-390450	1.332029e-01	0.875
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	7.860140e-02	1.105
mRNA Splicing - Minor Pathway	R-HSA-72165	1.195589e-01	0.922
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	1.195589e-01	0.922
Post-translational protein phosphorylation	R-HSA-8957275	1.195092e-01	0.923
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	1.124536e-01	0.949
Regulation of CDH11 function	R-HSA-9762292	1.332029e-01	0.875
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	9.169696e-02	1.038
Downstream signaling of activated FGFR2	R-HSA-5654696	7.860140e-02	1.105
IRF3 mediated activation of type 1 IFN	R-HSA-1606341	7.407210e-02	1.130
Activation of AKT2	R-HSA-165158	7.407210e-02	1.130
PTK6 Expression	R-HSA-8849473	1.041225e-01	0.982
Downstream signaling of activated FGFR1	R-HSA-5654687	7.860140e-02	1.105
Hh mutants are degraded by ERAD	R-HSA-5362768	9.846751e-02	1.007
Aryl hydrocarbon receptor signalling	R-HSA-8937144	8.419862e-02	1.075
Hh mutants abrogate ligand secretion	R-HSA-5387390	1.088754e-01	0.963
Generation of second messenger molecules	R-HSA-202433	9.506467e-02	1.022
PKB-mediated events	R-HSA-109703	8.419862e-02	1.075
PDE3B signalling	R-HSA-165160	8.419862e-02	1.075
p75NTR regulates axonogenesis	R-HSA-193697	1.236152e-01	0.908
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	1.332029e-01	0.875
Lysosome Vesicle Biogenesis	R-HSA-432720	8.181655e-02	1.087
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	9.846751e-02	1.007
Defective CFTR causes cystic fibrosis	R-HSA-5678895	1.159689e-01	0.936
eNOS activation	R-HSA-203615	7.542750e-02	1.122
Signaling by FGFR4	R-HSA-5654743	1.088754e-01	0.963
GP1b-IX-V activation signalling	R-HSA-430116	1.236152e-01	0.908
Signaling by FGFR3	R-HSA-5654741	1.159689e-01	0.936
GPVI-mediated activation cascade	R-HSA-114604	8.181655e-02	1.087
ROBO receptors bind AKAP5	R-HSA-9010642	1.139221e-01	0.943
DAP12 interactions	R-HSA-2172127	1.124073e-01	0.949
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	1.055652e-01	0.976
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	8.836556e-02	1.054
Netrin-1 signaling	R-HSA-373752	1.124073e-01	0.949
LDL remodeling	R-HSA-8964041	1.041225e-01	0.982
Axonal growth inhibition (RHOA activation)	R-HSA-193634	1.139221e-01	0.943
EGFR Transactivation by Gastrin	R-HSA-2179392	1.332029e-01	0.875
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	1.332029e-01	0.875
Negative regulation of NOTCH4 signaling	R-HSA-9604323	9.506467e-02	1.022
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	1.302379e-01	0.885
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	8.597400e-02	1.066
Co-stimulation by CD28	R-HSA-389356	1.268202e-01	0.897
FLT3 signaling in disease	R-HSA-9682385	8.181655e-02	1.087
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	8.507168e-02	1.070
Signaling by MET	R-HSA-6806834	7.387695e-02	1.131
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	1.101386e-01	0.958
Processing of DNA double-strand break ends	R-HSA-5693607	7.583672e-02	1.120
Intracellular signaling by second messengers	R-HSA-9006925	1.061212e-01	0.974
Golgi-to-ER retrograde transport	R-HSA-8856688	8.165102e-02	1.088
PCP/CE pathway	R-HSA-4086400	7.002697e-02	1.155
Regulation of CDH19 Expression and Function	R-HSA-9764302	8.419862e-02	1.075
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	8.419862e-02	1.075
Nef and signal transduction	R-HSA-164944	9.421501e-02	1.026
VLDL assembly	R-HSA-8866423	9.421501e-02	1.026
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	1.236152e-01	0.908
Attenuation phase	R-HSA-3371568	9.506467e-02	1.022
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	1.231763e-01	0.909
Regulation of T cell activation by CD28 family	R-HSA-388841	8.560002e-02	1.068
Platelet degranulation	R-HSA-114608	7.265774e-02	1.139
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	1.147873e-01	0.940
Extra-nuclear estrogen signaling	R-HSA-9009391	1.267247e-01	0.897
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	1.011906e-01	0.995
Josephin domain DUBs	R-HSA-5689877	1.332029e-01	0.875
Signalling to ERKs	R-HSA-187687	7.860140e-02	1.105
M Phase	R-HSA-68886	7.832805e-02	1.106
Sensory processing of sound	R-HSA-9659379	7.194029e-02	1.143
S Phase	R-HSA-69242	1.116999e-01	0.952
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	1.236152e-01	0.908
Regulation of necroptotic cell death	R-HSA-5675482	6.920868e-02	1.160
Cellular response to starvation	R-HSA-9711097	1.302379e-01	0.885
RIPK1-mediated regulated necrosis	R-HSA-5213460	8.836556e-02	1.054
Signaling by NTRKs	R-HSA-166520	1.116999e-01	0.952
Signaling by NTRK1 (TRKA)	R-HSA-187037	7.411960e-02	1.130
DAG and IP3 signaling	R-HSA-1489509	1.159689e-01	0.936
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	1.195589e-01	0.922
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	1.139221e-01	0.943
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	1.236152e-01	0.908
Heme biosynthesis	R-HSA-189451	1.019043e-01	0.992
Signaling by ALK	R-HSA-201556	9.169696e-02	1.038
Assembly of the pre-replicative complex	R-HSA-68867	1.055652e-01	0.976
Interleukin-23 signaling	R-HSA-9020933	1.139221e-01	0.943
Transport to the Golgi and subsequent modification	R-HSA-948021	9.817103e-02	1.008
KEAP1-NFE2L2 pathway	R-HSA-9755511	1.171304e-01	0.931
Cellular response to chemical stress	R-HSA-9711123	9.967191e-02	1.001
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	1.124073e-01	0.949
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	7.387695e-02	1.131
FGFR1 mutant receptor activation	R-HSA-1839124	6.920868e-02	1.160
Mitotic G1 phase and G1/S transition	R-HSA-453279	1.081440e-01	0.966
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	8.806746e-02	1.055
Interleukin-12 family signaling	R-HSA-447115	9.018235e-02	1.045
Transcriptional Regulation by TP53	R-HSA-3700989	8.950571e-02	1.048
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	9.169696e-02	1.038
Regulation of TP53 Activity	R-HSA-5633007	1.340912e-01	0.873
PI3K Cascade	R-HSA-109704	1.341833e-01	0.872
HSF1-dependent transactivation	R-HSA-3371571	1.379005e-01	0.860
The phototransduction cascade	R-HSA-2514856	1.379005e-01	0.860
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	1.416402e-01	0.849
Uptake and actions of bacterial toxins	R-HSA-5339562	1.416402e-01	0.849
Separation of Sister Chromatids	R-HSA-2467813	1.419361e-01	0.848
Selenoamino acid metabolism	R-HSA-2408522	1.419361e-01	0.848
vRNP Assembly	R-HSA-192905	1.426862e-01	0.846
Chylomicron assembly	R-HSA-8963888	1.426862e-01	0.846
RHOBTB3 ATPase cycle	R-HSA-9706019	1.426862e-01	0.846
Bicarbonate transporters	R-HSA-425381	1.426862e-01	0.846
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	1.426862e-01	0.846
Synthesis of DNA	R-HSA-69239	1.441417e-01	0.841
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	1.454016e-01	0.837
Regulation of PTEN stability and activity	R-HSA-8948751	1.454016e-01	0.837
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	1.491836e-01	0.826
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	1.492576e-01	0.826
DNA Replication Pre-Initiation	R-HSA-69002	1.492576e-01	0.826
Endosomal/Vacuolar pathway	R-HSA-1236977	1.520664e-01	0.818
G alpha (z) signalling events	R-HSA-418597	1.529854e-01	0.815
ESR-mediated signaling	R-HSA-8939211	1.547224e-01	0.810
Signaling by FGFR1	R-HSA-5654736	1.568062e-01	0.805
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	1.568062e-01	0.805
Signaling by EGFR	R-HSA-177929	1.568062e-01	0.805
Detoxification of Reactive Oxygen Species	R-HSA-3299685	1.568062e-01	0.805
FCERI mediated MAPK activation	R-HSA-2871796	1.570396e-01	0.804
Signaling by NOTCH	R-HSA-157118	1.599520e-01	0.796
Dectin-2 family	R-HSA-5621480	1.606450e-01	0.794
IRS-mediated signalling	R-HSA-112399	1.606450e-01	0.794
AKT phosphorylates targets in the cytosol	R-HSA-198323	1.613445e-01	0.792
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	1.613445e-01	0.792
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	1.613445e-01	0.792
Scavenging by Class F Receptors	R-HSA-3000484	1.613445e-01	0.792
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	1.613445e-01	0.792
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	1.613445e-01	0.792
Role of second messengers in netrin-1 signaling	R-HSA-418890	1.613445e-01	0.792
VLDLR internalisation and degradation	R-HSA-8866427	1.613445e-01	0.792
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	1.613445e-01	0.792
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	1.613445e-01	0.792
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	1.622965e-01	0.790
Early SARS-CoV-2 Infection Events	R-HSA-9772572	1.645010e-01	0.784
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	1.649449e-01	0.783
FCERI mediated Ca+2 mobilization	R-HSA-2871809	1.702800e-01	0.769
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	1.705217e-01	0.768
Platelet Adhesion to exposed collagen	R-HSA-75892	1.705217e-01	0.768
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	1.705217e-01	0.768
Neuronal System	R-HSA-112316	1.723379e-01	0.764
IRS-related events triggered by IGF1R	R-HSA-2428928	1.761641e-01	0.754
Transmission across Chemical Synapses	R-HSA-112315	1.781061e-01	0.749
Homology Directed Repair	R-HSA-5693538	1.783747e-01	0.749
PI3K/AKT Signaling in Cancer	R-HSA-2219528	1.783747e-01	0.749
Retrograde neurotrophin signalling	R-HSA-177504	1.795990e-01	0.746
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	1.795990e-01	0.746
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	1.795990e-01	0.746
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	1.795990e-01	0.746
CRMPs in Sema3A signaling	R-HSA-399956	1.795990e-01	0.746
Malate-aspartate shuttle	R-HSA-9856872	1.795990e-01	0.746
Signal regulatory protein family interactions	R-HSA-391160	1.795990e-01	0.746
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	1.800808e-01	0.745
Complex I biogenesis	R-HSA-6799198	1.840108e-01	0.735
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	1.865735e-01	0.729
Deubiquitination	R-HSA-5688426	1.871350e-01	0.728
CD22 mediated BCR regulation	R-HSA-5690714	1.879532e-01	0.726
IGF1R signaling cascade	R-HSA-2428924	1.879532e-01	0.726
Insulin receptor signalling cascade	R-HSA-74751	1.879532e-01	0.726
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	1.885775e-01	0.725
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	1.885775e-01	0.725
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	1.885775e-01	0.725
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	1.885775e-01	0.725
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	1.885775e-01	0.725
DCC mediated attractive signaling	R-HSA-418885	1.885775e-01	0.725
IRF3-mediated induction of type I IFN	R-HSA-3270619	1.885775e-01	0.725
ERBB2 Regulates Cell Motility	R-HSA-6785631	1.885775e-01	0.725
Protein lipoylation	R-HSA-9857492	1.885775e-01	0.725
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	1.885775e-01	0.725
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	1.885775e-01	0.725
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	1.919074e-01	0.717
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	1.919074e-01	0.717
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	1.974583e-01	0.705
Entry of Influenza Virion into Host Cell via Endocytosis	R-HSA-168275	1.974583e-01	0.705
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	1.974583e-01	0.705
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	1.974583e-01	0.705
Attachment and Entry	R-HSA-9678110	1.974583e-01	0.705
G1/S Transition	R-HSA-69206	2.004502e-01	0.698
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	2.036549e-01	0.691
Regulated Necrosis	R-HSA-5218859	2.038331e-01	0.691
Processing of Intronless Pre-mRNAs	R-HSA-77595	2.062424e-01	0.686
TRAF3-dependent IRF activation pathway	R-HSA-918233	2.062424e-01	0.686
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	2.062424e-01	0.686
Acetylcholine regulates insulin secretion	R-HSA-399997	2.062424e-01	0.686
Passive transport by Aquaporins	R-HSA-432047	2.062424e-01	0.686
Cyclin E associated events during G1/S transition	R-HSA-69202	2.118295e-01	0.674
Negative regulation of the PI3K/AKT network	R-HSA-199418	2.145639e-01	0.668
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	2.149310e-01	0.668
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	2.149310e-01	0.668
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	2.149310e-01	0.668
Choline catabolism	R-HSA-6798163	2.149310e-01	0.668
Signaling by Hippo	R-HSA-2028269	2.149310e-01	0.668
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	2.158394e-01	0.666
Regulation of mitotic cell cycle	R-HSA-453276	2.158394e-01	0.666
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	2.158394e-01	0.666
Metabolism of porphyrins	R-HSA-189445	2.158394e-01	0.666
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	2.198563e-01	0.658
Co-inhibition by PD-1	R-HSA-389948	2.219248e-01	0.654
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	2.235249e-01	0.651
Depolymerization of the Nuclear Lamina	R-HSA-4419969	2.235249e-01	0.651
GAB1 signalosome	R-HSA-180292	2.235249e-01	0.651
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	2.235249e-01	0.651
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	2.288866e-01	0.640
IKK complex recruitment mediated by RIP1	R-HSA-937041	2.320254e-01	0.634
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	2.320254e-01	0.634
PI-3K cascade:FGFR3	R-HSA-5654710	2.320254e-01	0.634
Signaling by FGFR2 IIIa TM	R-HSA-8851708	2.320254e-01	0.634
Rap1 signalling	R-HSA-392517	2.320254e-01	0.634
Translesion Synthesis by POLH	R-HSA-110320	2.320254e-01	0.634
The NLRP3 inflammasome	R-HSA-844456	2.320254e-01	0.634
UCH proteinases	R-HSA-5689603	2.359812e-01	0.627
Beta-catenin independent WNT signaling	R-HSA-3858494	2.375605e-01	0.624
Estrogen-dependent gene expression	R-HSA-9018519	2.375605e-01	0.624
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	2.404332e-01	0.619
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	2.404332e-01	0.619
PI-3K cascade:FGFR4	R-HSA-5654720	2.404332e-01	0.619
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	2.404332e-01	0.619
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	2.404658e-01	0.619
ABC transporter disorders	R-HSA-5619084	2.440698e-01	0.612
PTEN Regulation	R-HSA-6807070	2.462944e-01	0.609
Unfolded Protein Response (UPR)	R-HSA-381119	2.462944e-01	0.609
TNFR1-induced proapoptotic signaling	R-HSA-5357786	2.487496e-01	0.604
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	2.569754e-01	0.590
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	2.569754e-01	0.590
Signaling by PDGFR in disease	R-HSA-9671555	2.569754e-01	0.590
FRS-mediated FGFR3 signaling	R-HSA-5654706	2.569754e-01	0.590
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	2.569754e-01	0.590
Signaling by NTRK3 (TRKC)	R-HSA-9034015	2.569754e-01	0.590
Attachment and Entry	R-HSA-9694614	2.569754e-01	0.590
Mitotic Anaphase	R-HSA-68882	2.620462e-01	0.582
Mitotic Metaphase and Anaphase	R-HSA-2555396	2.644514e-01	0.578
PI-3K cascade:FGFR1	R-HSA-5654689	2.651116e-01	0.577
FRS-mediated FGFR4 signaling	R-HSA-5654712	2.651116e-01	0.577
LDL clearance	R-HSA-8964038	2.651116e-01	0.577
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	2.651116e-01	0.577
PIP3 activates AKT signaling	R-HSA-1257604	2.664661e-01	0.574
Protein-protein interactions at synapses	R-HSA-6794362	2.724418e-01	0.565
Signaling by WNT	R-HSA-195721	2.727204e-01	0.564
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	2.731592e-01	0.564
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	2.731592e-01	0.564
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	2.731592e-01	0.564
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	2.764960e-01	0.558
Gastrulation	R-HSA-9758941	2.787017e-01	0.555
XBP1(S) activates chaperone genes	R-HSA-381038	2.805490e-01	0.552
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	2.811192e-01	0.551
Deadenylation of mRNA	R-HSA-429947	2.811192e-01	0.551
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	2.811192e-01	0.551
Plasma lipoprotein assembly	R-HSA-8963898	2.811192e-01	0.551
Complex III assembly	R-HSA-9865881	2.811192e-01	0.551
CD209 (DC-SIGN) signaling	R-HSA-5621575	2.811192e-01	0.551
Diseases of programmed cell death	R-HSA-9645723	2.886496e-01	0.540
HIV Infection	R-HSA-162906	2.887155e-01	0.540
PI-3K cascade:FGFR2	R-HSA-5654695	2.889925e-01	0.539
FRS-mediated FGFR1 signaling	R-HSA-5654693	2.889925e-01	0.539
Long-term potentiation	R-HSA-9620244	2.889925e-01	0.539
HDMs demethylate histones	R-HSA-3214842	2.889925e-01	0.539
Sema4D in semaphorin signaling	R-HSA-400685	2.889925e-01	0.539
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	2.889925e-01	0.539
Protein localization	R-HSA-9609507	2.905956e-01	0.537
DNA Replication	R-HSA-69306	2.905956e-01	0.537
DNA Double-Strand Break Repair	R-HSA-5693532	2.905956e-01	0.537
Death Receptor Signaling	R-HSA-73887	2.935753e-01	0.532
Downstream TCR signaling	R-HSA-202424	2.967401e-01	0.528
MET activates PTK2 signaling	R-HSA-8874081	2.967801e-01	0.528
Myogenesis	R-HSA-525793	2.967801e-01	0.528
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	2.967801e-01	0.528
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	2.967801e-01	0.528
RNA Polymerase I Transcription Termination	R-HSA-73863	3.044829e-01	0.516
CD28 dependent PI3K/Akt signaling	R-HSA-389357	3.044829e-01	0.516
Insulin processing	R-HSA-264876	3.044829e-01	0.516
IRE1alpha activates chaperones	R-HSA-381070	3.048171e-01	0.516
Chromatin modifying enzymes	R-HSA-3247509	3.058871e-01	0.514
Signaling by Insulin receptor	R-HSA-74752	3.088496e-01	0.510
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	3.088496e-01	0.510
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	3.121017e-01	0.506
Formation of the Early Elongation Complex	R-HSA-113418	3.121017e-01	0.506
FRS-mediated FGFR2 signaling	R-HSA-5654700	3.121017e-01	0.506
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	3.121017e-01	0.506
Negative regulation of FGFR3 signaling	R-HSA-5654732	3.121017e-01	0.506
Inflammasomes	R-HSA-622312	3.121017e-01	0.506
Iron assimilation using enterobactin	R-HSA-9638334	3.121017e-01	0.506
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	3.169004e-01	0.499
Mitochondrial protein degradation	R-HSA-9837999	3.169004e-01	0.499
Late endosomal microautophagy	R-HSA-9615710	3.196376e-01	0.495
Regulation of CDH11 Expression and Function	R-HSA-9759475	3.196376e-01	0.495
Negative regulation of FGFR4 signaling	R-HSA-5654733	3.196376e-01	0.495
mRNA Capping	R-HSA-72086	3.196376e-01	0.495
Regulation of gene expression in beta cells	R-HSA-210745	3.196376e-01	0.495
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	3.270913e-01	0.485
SHC1 events in ERBB2 signaling	R-HSA-1250196	3.270913e-01	0.485
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	3.270913e-01	0.485
Activation of the pre-replicative complex	R-HSA-68962	3.270913e-01	0.485
Interleukin-37 signaling	R-HSA-9008059	3.270913e-01	0.485
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	3.289359e-01	0.483
CLEC7A (Dectin-1) signaling	R-HSA-5607764	3.289359e-01	0.483
Trafficking of AMPA receptors	R-HSA-399719	3.344639e-01	0.476
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	3.344639e-01	0.476
Aspartate and asparagine metabolism	R-HSA-8963693	3.344639e-01	0.476
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	3.344639e-01	0.476
HATs acetylate histones	R-HSA-3214847	3.409140e-01	0.467
p75 NTR receptor-mediated signalling	R-HSA-193704	3.409140e-01	0.467
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	3.417561e-01	0.466
Diseases of mitotic cell cycle	R-HSA-9675126	3.417561e-01	0.466
Chromatin organization	R-HSA-4839726	3.429984e-01	0.465
ABC-family proteins mediated transport	R-HSA-382556	3.448924e-01	0.462
C-type lectin receptors (CLRs)	R-HSA-5621481	3.473831e-01	0.459
Nuclear RNA decay	R-HSA-9930044	3.489689e-01	0.457
Transport of the SLBP independent Mature mRNA	R-HSA-159227	3.489689e-01	0.457
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	3.489689e-01	0.457
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	3.489689e-01	0.457
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	3.489689e-01	0.457
Negative regulation of FGFR1 signaling	R-HSA-5654726	3.489689e-01	0.457
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	3.489689e-01	0.457
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	3.489689e-01	0.457
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	3.489689e-01	0.457
G-protein beta:gamma signalling	R-HSA-397795	3.489689e-01	0.457
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	3.489689e-01	0.457
Regulation of PD-L1(CD274) expression	R-HSA-9909648	3.503703e-01	0.455
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	3.528258e-01	0.452
Ub-specific processing proteases	R-HSA-5689880	3.533561e-01	0.452
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	3.561031e-01	0.448
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	3.561031e-01	0.448
DNA Damage Recognition in GG-NER	R-HSA-5696394	3.561031e-01	0.448
Vpu mediated degradation of CD4	R-HSA-180534	3.561031e-01	0.448
Effects of PIP2 hydrolysis	R-HSA-114508	3.561031e-01	0.448
Glutamate and glutamine metabolism	R-HSA-8964539	3.561031e-01	0.448
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	3.607261e-01	0.443
Response of endothelial cells to shear stress	R-HSA-9860931	3.607261e-01	0.443
Asparagine N-linked glycosylation	R-HSA-446203	3.607930e-01	0.443
Mitophagy	R-HSA-5205647	3.631595e-01	0.440
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	3.631595e-01	0.440
Negative regulation of FGFR2 signaling	R-HSA-5654727	3.631595e-01	0.440
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	3.631595e-01	0.440
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	3.631595e-01	0.440
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	3.631595e-01	0.440
Respiratory electron transport	R-HSA-611105	3.682587e-01	0.434
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	3.685909e-01	0.433
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	3.701391e-01	0.432
PERK regulates gene expression	R-HSA-381042	3.701391e-01	0.432
Regulation of Apoptosis	R-HSA-169911	3.701391e-01	0.432
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	3.701391e-01	0.432
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	3.770425e-01	0.424
Vif-mediated degradation of APOBEC3G	R-HSA-180585	3.770425e-01	0.424
Calmodulin induced events	R-HSA-111933	3.770425e-01	0.424
CaM pathway	R-HSA-111997	3.770425e-01	0.424
Triglyceride catabolism	R-HSA-163560	3.770425e-01	0.424
FGFR2 mutant receptor activation	R-HSA-1839126	3.770425e-01	0.424
Regulation of TP53 Degradation	R-HSA-6804757	3.770425e-01	0.424
Antigen processing-Cross presentation	R-HSA-1236975	3.803168e-01	0.420
TCF dependent signaling in response to WNT	R-HSA-201681	3.831030e-01	0.417
Voltage gated Potassium channels	R-HSA-1296072	3.838708e-01	0.416
TRAF6 mediated IRF7 activation	R-HSA-933541	3.838708e-01	0.416
Degradation of DVL	R-HSA-4641258	3.838708e-01	0.416
Degradation of AXIN	R-HSA-4641257	3.838708e-01	0.416
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	3.838708e-01	0.416
Ovarian tumor domain proteases	R-HSA-5689896	3.838708e-01	0.416
Lysine catabolism	R-HSA-71064	3.838708e-01	0.416
MyD88-independent TLR4 cascade	R-HSA-166166	3.880836e-01	0.411
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	3.880836e-01	0.411
SLC-mediated transport of inorganic anions	R-HSA-9958790	3.906246e-01	0.408
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	3.973048e-01	0.401
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	3.973048e-01	0.401
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	3.973048e-01	0.401
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	3.973048e-01	0.401
Plasma lipoprotein clearance	R-HSA-8964043	3.973048e-01	0.401
Stabilization of p53	R-HSA-69541	3.973048e-01	0.401
Regulation of TP53 Expression and Degradation	R-HSA-6806003	3.973048e-01	0.401
Cellular responses to mechanical stimuli	R-HSA-9855142	4.034874e-01	0.394
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	4.039121e-01	0.394
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	4.039121e-01	0.394
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	4.039121e-01	0.394
HIV Transcription Elongation	R-HSA-167169	4.039121e-01	0.394
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	4.039121e-01	0.394
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	4.039121e-01	0.394
Diseases of Immune System	R-HSA-5260271	4.039121e-01	0.394
Diseases associated with the TLR signaling cascade	R-HSA-5602358	4.039121e-01	0.394
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	4.039121e-01	0.394
Nuclear signaling by ERBB4	R-HSA-1251985	4.039121e-01	0.394
Regulation of RUNX3 expression and activity	R-HSA-8941858	4.039121e-01	0.394
DNA Repair	R-HSA-73894	4.060765e-01	0.391
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	4.104475e-01	0.387
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	4.104475e-01	0.387
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	4.104475e-01	0.387
Transcriptional Regulation by VENTX	R-HSA-8853884	4.104475e-01	0.387
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	4.104475e-01	0.387
Signaling by Nuclear Receptors	R-HSA-9006931	4.125698e-01	0.385
Interferon alpha/beta signaling	R-HSA-909733	4.149198e-01	0.382
Degradation of CRY and PER proteins	R-HSA-9932298	4.169116e-01	0.380
Degradation of GLI1 by the proteasome	R-HSA-5610780	4.169116e-01	0.380
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	4.169116e-01	0.380
Degradation of GLI2 by the proteasome	R-HSA-5610783	4.169116e-01	0.380
HCMV Early Events	R-HSA-9609690	4.212943e-01	0.375
Rab regulation of trafficking	R-HSA-9007101	4.224810e-01	0.374
Mitochondrial biogenesis	R-HSA-1592230	4.224810e-01	0.374
RNA Polymerase I Transcription Initiation	R-HSA-73762	4.233052e-01	0.373
Ca-dependent events	R-HSA-111996	4.233052e-01	0.373
MTOR signalling	R-HSA-165159	4.233052e-01	0.373
Transcriptional regulation by RUNX2	R-HSA-8878166	4.299920e-01	0.367
Surfactant metabolism	R-HSA-5683826	4.358840e-01	0.361
Proteasome assembly	R-HSA-9907900	4.358840e-01	0.361
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	4.358840e-01	0.361
RMTs methylate histone arginines	R-HSA-3214858	4.358840e-01	0.361
G1 Phase	R-HSA-69236	4.358840e-01	0.361
Cyclin D associated events in G1	R-HSA-69231	4.358840e-01	0.361
Asymmetric localization of PCP proteins	R-HSA-4608870	4.420707e-01	0.355
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	4.420707e-01	0.355
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	4.420707e-01	0.355
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	4.420707e-01	0.355
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	4.420707e-01	0.355
Somitogenesis	R-HSA-9824272	4.420707e-01	0.355
Degradation of cysteine and homocysteine	R-HSA-1614558	4.420707e-01	0.355
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	4.448585e-01	0.352
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	4.481900e-01	0.349
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	4.481900e-01	0.349
Regulation of TNFR1 signaling	R-HSA-5357905	4.481900e-01	0.349
Host Interactions of HIV factors	R-HSA-162909	4.485417e-01	0.348
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	4.542425e-01	0.343
Plasma lipoprotein remodeling	R-HSA-8963899	4.602290e-01	0.337
DNA Damage Bypass	R-HSA-73893	4.661502e-01	0.331
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	4.661502e-01	0.331
Glyoxylate metabolism and glycine degradation	R-HSA-389661	4.661502e-01	0.331
p53-Dependent G1 DNA Damage Response	R-HSA-69563	4.661502e-01	0.331
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	4.661502e-01	0.331
Regulation of RAS by GAPs	R-HSA-5658442	4.720068e-01	0.326
Bacterial Infection Pathways	R-HSA-9824439	4.725004e-01	0.326
Activation of NF-kappaB in B cells	R-HSA-1169091	4.777995e-01	0.321
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	4.777995e-01	0.321
mRNA 3'-end processing	R-HSA-72187	4.835290e-01	0.316
Formation of RNA Pol II elongation complex	R-HSA-112382	4.835290e-01	0.316
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	4.835290e-01	0.316
Orc1 removal from chromatin	R-HSA-68949	4.835290e-01	0.316
Neurexins and neuroligins	R-HSA-6794361	4.835290e-01	0.316
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	4.835290e-01	0.316
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	4.835290e-01	0.316
RNA Polymerase II Transcription Elongation	R-HSA-75955	4.891960e-01	0.311
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	4.891960e-01	0.311
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	4.891960e-01	0.311
HDACs deacetylate histones	R-HSA-3214815	5.003452e-01	0.301
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	5.003452e-01	0.301
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	5.058287e-01	0.296
TNF signaling	R-HSA-75893	5.058287e-01	0.296
Nuclear Envelope Breakdown	R-HSA-2980766	5.112524e-01	0.291
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	5.166168e-01	0.287
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	5.167748e-01	0.287
Deadenylation-dependent mRNA decay	R-HSA-429914	5.219228e-01	0.282
snRNP Assembly	R-HSA-191859	5.219228e-01	0.282
Metabolism of non-coding RNA	R-HSA-194441	5.219228e-01	0.282
Triglyceride metabolism	R-HSA-8979227	5.219228e-01	0.282
Regulation of beta-cell development	R-HSA-186712	5.219228e-01	0.282
Late Phase of HIV Life Cycle	R-HSA-162599	5.259037e-01	0.279
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	5.271708e-01	0.278
Regulation of PTEN gene transcription	R-HSA-8943724	5.271708e-01	0.278
Metabolism of polyamines	R-HSA-351202	5.271708e-01	0.278
RNA Polymerase II Transcription Termination	R-HSA-73856	5.323615e-01	0.274
Aquaporin-mediated transport	R-HSA-445717	5.323615e-01	0.274
Regulation of RUNX2 expression and activity	R-HSA-8939902	5.323615e-01	0.274
PLC beta mediated events	R-HSA-112043	5.323615e-01	0.274
Formation of paraxial mesoderm	R-HSA-9793380	5.323615e-01	0.274
FCERI mediated NF-kB activation	R-HSA-2871837	5.325691e-01	0.274
NCAM signaling for neurite out-growth	R-HSA-375165	5.374955e-01	0.270
Cell surface interactions at the vascular wall	R-HSA-202733	5.380263e-01	0.269
Visual phototransduction	R-HSA-2187338	5.424476e-01	0.266
G1/S DNA Damage Checkpoints	R-HSA-69615	5.425735e-01	0.266
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	5.425735e-01	0.266
Signaling by PTK6	R-HSA-8848021	5.425735e-01	0.266
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	5.457084e-01	0.263
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	5.475961e-01	0.262
Cellular response to hypoxia	R-HSA-1234174	5.525638e-01	0.258
Metabolism of amino acids and derivatives	R-HSA-71291	5.569030e-01	0.254
Interleukin-1 family signaling	R-HSA-446652	5.585897e-01	0.253
G-protein mediated events	R-HSA-112040	5.623371e-01	0.250
Disorders of transmembrane transporters	R-HSA-5619115	5.638329e-01	0.249
Transcription of the HIV genome	R-HSA-167172	5.671439e-01	0.246
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	5.671439e-01	0.246
HCMV Infection	R-HSA-9609646	5.714040e-01	0.243
HIV Life Cycle	R-HSA-162587	5.743254e-01	0.241
COPII-mediated vesicle transport	R-HSA-204005	5.766004e-01	0.239
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	5.766004e-01	0.239
Degradation of beta-catenin by the destruction complex	R-HSA-195253	5.766004e-01	0.239
Interferon gamma signaling	R-HSA-877300	5.805052e-01	0.236
NoRC negatively regulates rRNA expression	R-HSA-427413	5.812514e-01	0.236
Metabolism of cofactors	R-HSA-8978934	5.812514e-01	0.236
Hedgehog 'on' state	R-HSA-5632684	5.812514e-01	0.236
Metal ion assimilation from the host	R-HSA-9638482	5.812514e-01	0.236
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	5.904015e-01	0.229
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	5.904015e-01	0.229
Ca2+ pathway	R-HSA-4086398	5.904015e-01	0.229
Metabolism of proteins	R-HSA-392499	5.912776e-01	0.228
Signaling by ERBB4	R-HSA-1236394	5.949017e-01	0.226
RNA Polymerase II Pre-transcription Events	R-HSA-674695	5.949017e-01	0.226
Protein ubiquitination	R-HSA-8852135	5.993527e-01	0.222
Iron uptake and transport	R-HSA-917937	5.993527e-01	0.222
RNA Polymerase I Promoter Clearance	R-HSA-73854	6.037551e-01	0.219
Signaling by NOTCH1	R-HSA-1980143	6.037551e-01	0.219
G alpha (q) signalling events	R-HSA-416476	6.056506e-01	0.218
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	6.081094e-01	0.216
RNA Polymerase I Transcription	R-HSA-73864	6.124161e-01	0.213
Integrin cell surface interactions	R-HSA-216083	6.124161e-01	0.213
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	6.208888e-01	0.207
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	6.208888e-01	0.207
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	6.291774e-01	0.201
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	6.291774e-01	0.201
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	6.332538e-01	0.198
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	6.372857e-01	0.196
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	6.372857e-01	0.196
MAPK6/MAPK4 signaling	R-HSA-5687128	6.412735e-01	0.193
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	6.469654e-01	0.189
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	6.491189e-01	0.188
Sulfur amino acid metabolism	R-HSA-1614635	6.491189e-01	0.188
Class I MHC mediated antigen processing & presentation	R-HSA-983169	6.507452e-01	0.187
ER-Phagosome pathway	R-HSA-1236974	6.605680e-01	0.180
Toll-like Receptor Cascades	R-HSA-168898	6.730172e-01	0.172
Collagen formation	R-HSA-1474290	6.823638e-01	0.166
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	6.858586e-01	0.164
Potassium Channels	R-HSA-1296071	6.927339e-01	0.159
Transcriptional regulation by RUNX3	R-HSA-8878159	6.961152e-01	0.157
Regulation of insulin secretion	R-HSA-422356	6.994596e-01	0.155
Interleukin-1 signaling	R-HSA-9020702	7.092746e-01	0.149
Regulation of endogenous retroelements	R-HSA-9842860	7.124749e-01	0.147
Mitochondrial ribosome-associated quality control	R-HSA-9937383	7.156402e-01	0.145
Opioid Signalling	R-HSA-111885	7.187708e-01	0.143
RSV-host interactions	R-HSA-9833110	7.218672e-01	0.142
Nucleotide Excision Repair	R-HSA-5696398	7.249297e-01	0.140
Gene Silencing by RNA	R-HSA-211000	7.309543e-01	0.136
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	7.339173e-01	0.134
MyD88 dependent cascade initiated on endosome	R-HSA-975155	7.368478e-01	0.133
Neddylation	R-HSA-8951664	7.442634e-01	0.128
Inositol phosphate metabolism	R-HSA-1483249	7.454481e-01	0.128
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	7.482523e-01	0.126
Transcriptional regulation by RUNX1	R-HSA-8878171	7.544288e-01	0.122
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	7.564820e-01	0.121
Aerobic respiration and respiratory electron transport	R-HSA-1428517	7.604886e-01	0.119
Peptide hormone metabolism	R-HSA-2980736	7.644441e-01	0.117
Mitotic Prophase	R-HSA-68875	7.721473e-01	0.112
Metabolism of nucleotides	R-HSA-15869	7.737231e-01	0.111
Nuclear events mediated by NFE2L2	R-HSA-9759194	7.746589e-01	0.111
Maternal to zygotic transition (MZT)	R-HSA-9816359	7.795999e-01	0.108
Formation of the cornified envelope	R-HSA-6809371	7.820299e-01	0.107
Adipogenesis	R-HSA-9843745	8.027348e-01	0.095
Degradation of the extracellular matrix	R-HSA-1474228	8.049110e-01	0.094
Circadian clock	R-HSA-9909396	8.049110e-01	0.094
Integration of energy metabolism	R-HSA-163685	8.154393e-01	0.089
Mitochondrial translation	R-HSA-5368287	8.194906e-01	0.086
Generic Transcription Pathway	R-HSA-212436	8.310096e-01	0.080
Post-translational protein modification	R-HSA-597592	8.352107e-01	0.078
Gene expression (Transcription)	R-HSA-74160	8.413507e-01	0.075
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	8.437523e-01	0.074
RNA Polymerase II Transcription	R-HSA-73857	8.568273e-01	0.067
SLC transporter disorders	R-HSA-5619102	8.706513e-01	0.060
Cellular Senescence	R-HSA-2559583	8.893059e-01	0.051
Epigenetic regulation of gene expression	R-HSA-212165	8.926288e-01	0.049
Peptide ligand-binding receptors	R-HSA-375276	8.964575e-01	0.047
Infection with Enterobacteria	R-HSA-9640148	9.143206e-01	0.039
Keratinization	R-HSA-6805567	9.180569e-01	0.037
Transport of small molecules	R-HSA-382551	9.283649e-01	0.032
Phase I - Functionalization of compounds	R-HSA-211945	9.633458e-01	0.016
GPCR downstream signalling	R-HSA-388396	9.769826e-01	0.010
Metabolism of vitamins and cofactors	R-HSA-196854	9.860457e-01	0.006
Signaling by GPCR	R-HSA-372790	9.883757e-01	0.005
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	9.901608e-01	0.004
SLC-mediated transmembrane transport	R-HSA-425407	9.904883e-01	0.004
G alpha (i) signalling events	R-HSA-418594	9.915036e-01	0.004
Fatty acid metabolism	R-HSA-8978868	9.915036e-01	0.004
Biological oxidations	R-HSA-211859	9.977183e-01	0.001
Sensory Perception	R-HSA-9709957	9.984808e-01	0.001
GPCR ligand binding	R-HSA-500792	9.989248e-01	0.000
Metabolism	R-HSA-1430728	9.999948e-01	0.000
Metabolism of lipids	R-HSA-556833	9.999995e-01	0.000