TESK1

TYR version of PSPA with Y as phospho-acceptor
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Y Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Log-Odds: Y Sites / Y Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A5A3E0 S1068 Sugiyama POTEF A26C1B SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
A5A3E0 S939 Sugiyama POTEF A26C1B VALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPE
A5A3E0 Y940 Sugiyama POTEF A26C1B ALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPEA
A6NMY6 Y333 Sugiyama ANXA2P2 ANX2L2 ANX2P2 LPC2B KsLyyyIQQDTKGDyQKALLyLCGGDD______________
O14910 Y133 Sugiyama LIN7A MALS1 VELI1 KTDEGLGFNVMGGKEQNsPIyIsRIIPGGVAERHGGLKRGD
O60361 Y136 Sugiyama NME2P1 SLRFKPEELVDYKSCAHDWVyE___________________
O95394 S64 Sugiyama PGM3 AGM1 LLAVLRSKQTKSTIGVMVtAsHNPEEDNGVKLVDPLGEMLA
P00338 S161 Sugiyama LDHA PIG19 DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00338 Y10 Sugiyama LDHA PIG19 ___________MAtLKDQLIyNLLKEEQtPQNKITVVGVGA
P00338 Y172 Sugiyama LDHA PIG19 GFPKNRVIGsGCNLDsARFRyLMGERLGVHPLSCHGWVLGE
P00505 Y179 Sugiyama GOT2 KYAT4 KPTWGNHtPIFRDAGMQLQGyRYYDPKtCGFDFtGAVEDIS
P00558 Y161 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 KAEPAKIEAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNL
P00966 Y359 Sugiyama ASS1 ASS AKSQERVEGKVQVSVLKGQVyILGRESPLSLYNEELVSMNV
P04075 S336 Sugiyama ALDOA ALDA GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 Y320 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 GIALNDHFVKLIsWyDNEFGysNRVVDLMAHMAsKE_____
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P06733 S27 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 HAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEAL
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P07195 S162 Sugiyama LDHB DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07205 Y161 Sugiyama PGK2 PGKB KAEPDKIEAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNL
P07237 Y94 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB GSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFFRNGDTASPK
P07355 Y333 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D KsLyyyIQQDTKGDyQKALLyLCGGDD______________
P07437 Y50 Sugiyama TUBB TUBB5 OK/SW-cl.56 IDPTGtyHGDsDLQLDRIsVyyNEAtGGKyVPRAILVDLEP
P07686 Y547 Sugiyama HEXB HCC7 DRLTRHRCRMVERGIAAQPLyAGyCNHENM___________
P07737 S85 Sugiyama PFN1 tLGGQKCsVIRDsLLQDGEFsMDLRtKstGGAPTFNVtVtK
P07864 S161 Sugiyama LDHC LDH3 LDHX DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900 Y284 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DEEEEKKDGDKKKKKKIKEKyIDQEELNKtKPIWtRNPDDI
P07900 Y309 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA ELNKtKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHF
P07900 Y492 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DEMVsLKDYCTRMKENQKHIyyItGETKDQVANsAFVERLR
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 Y276 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DEEDDsGKDKKKKTKKIKEKyIDQEELNKtKPIWtRNPDDI
P08238 Y301 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB ELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHF
P08238 Y484 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DEMtsLsEyVsRMKEtQKsIyyItGEsKEQVANsAFVERVR
P08238 Y485 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB EMtsLsEyVsRMKEtQKsIyyItGEsKEQVANsAFVERVRK
P0CG38 S1068 Sugiyama POTEI SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39 S1031 Sugiyama POTEJ SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P10809 Y243 Sugiyama HSPD1 HSP60 yIsPyFINtsKGQKCEFQDAyVLLsEKKIssIQsIVPALEI
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11142 T226 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11142 Y41 Sugiyama HSPA8 HSC70 HSP73 HSPA10 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P13639 Y639 Sugiyama EEF2 EF2 KGEVsARQELKQRARyLAEKyEWDVAEARKIWCFGPDGTGP
P13639 Y671 Sugiyama EEF2 EF2 CFGPDGTGPNILTDITKGVQyLNEIKDSVVAGFQWATKEGA
P13674 Y282 Sugiyama P4HA1 P4HA ASDDQSDQKTTPKKKGVAVDyLPERQKyEMLCRGEGIKMTP
P14314 T469 Sugiyama PRKCSH G19P1 WGsWIGPDHDKFSAMKyEQGtGCWQGPNRstTVRLLCGKEt
P15259 Y92 Sugiyama PGAM2 PGAMM DGTDQMWLPVVRTWRLNERHyGGLtGLNKAETAAKHGEEQV
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17066 T228 Sugiyama HSPA6 HSP70B' DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR
P17066 Y43 Sugiyama HSPA6 HSP70B' FQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAAL
P18669 Y92 Sugiyama PGAM1 PGAMA CDABP0006 DAIDQMWLPVVRTWRLNERHyGGLtGLNKAETAAKHGEAQV
P19338 Y462 Sugiyama NCL AEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNSTWs
P22392 Y151 Sugiyama NME2 NM23B SLWFKPEELVDyKSCAHDWVyE___________________
P22626 S212 Sugiyama HNRNPA2B1 HNRPA2B1 EMQEVQssRsGRGGNFGFGDsRGGGGNFGPGPGsNFRGGsD
P22626 S225 Sugiyama HNRNPA2B1 HNRPA2B1 GNFGFGDsRGGGGNFGPGPGsNFRGGsDGyGsGRGFGDGyN
P22626 S344 Sugiyama HNRNPA2B1 HNRPA2B1 sRNMGGPyGGGNyGPGGsGGsGGyGGRsRy___________
P23526 Y193 Sugiyama AHCY SAHH LKVPAINVNDsVtKsKFDNLyGCRESLIDGIKRATDVMIAG
P23528 S3 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP CFL1 CFL __________________MAsGVAVsDGVIKVFNDMKVRKs
P26641 T287 Sugiyama EEF1G EF1G PRO1608 EQALAAEPKAKDPFAHLPKstFVLDEFKRKysNEDtLsVAL
P27348 Y48 Sugiyama YWHAQ AVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSIEQK
P27824 Y70 Sugiyama CANX TAPPSSPKVTYKAPVPtGEVyFADsFDRGTLSGWILSKAKK
P28066 S179 Sugiyama PSMA5 sGtFVQCDARAIGsAsEGAQssLQEVyHKSMTLKEAIKSSL
P28074 Y171 Sugiyama PSMB5 LMPX MB1 X GMGLSMGTMICGWDKRGPGLyyVDsEGNRISGATFSVGSGS
P29401 S443 Sugiyama TKT EDGPSQMALEDLAMFRsVPtstVFyPsDGVAtEKAVELAAN
P29401 T444 Sugiyama TKT DGPSQMALEDLAMFRsVPtstVFyPsDGVAtEKAVELAANT
P29401 Y481 Sugiyama TKT AANTKGICFIRTsRPENAIIyNNNEDFQVGQAKVVLKSKDD
P29692 S65 Sugiyama EEF1D EF1D VILRDIARARENIQKsLAGssGPGAssGtsGDHGELVVRIA
P30050 S138 Sugiyama RPL12 HRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDINsG
P30101 S155 Sugiyama PDIA3 ERP57 ERP60 GRP58 ASVPLRTEEEFKKFISDKDAsIVGFFDDsFsEAHsEFLKAA
P30101 S163 Sugiyama PDIA3 ERP57 ERP60 GRP58 EEFKKFISDKDAsIVGFFDDsFsEAHsEFLKAASNLRDNYR
P30101 S165 Sugiyama PDIA3 ERP57 ERP60 GRP58 FKKFISDKDAsIVGFFDDsFsEAHsEFLKAASNLRDNYRFA
P30101 S169 Sugiyama PDIA3 ERP57 ERP60 GRP58 ISDKDAsIVGFFDDsFsEAHsEFLKAASNLRDNYRFAHTNV
P31943 Y266 Sugiyama HNRNPH1 HNRPH HNRPH1 yNGYNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGstFQst
P31946 Y50 Sugiyama YWHAB AVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSIEQK
P31947 Y48 Sugiyama SFN HME1 GAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsIEQK
P31948 Y354 Sugiyama STIP1 DVLKKCQQAEKILKEQERLAyINPDLALEEKNKGNECFQKG
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P34931 T228 Sugiyama HSPA1L DVSILTIDDGIFEVKAtAGDtHLGGEDFDNRLVsHFVEEFK
P34931 Y43 Sugiyama HSPA1L FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P38646 Y196 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 EtAENyLGHtAKNAVItVPAyFNDsQRQAtKDAGQIsGLNV
P39019 Y54 Sugiyama RPS19 VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P40227 S246 Sugiyama CCT6A CCT6 CCTZ EDAyILTCNVSLEYEKTEVNsGFFyKSAEEREKLVKAERKF
P46777 S172 Sugiyama RPL5 MSTP030 RTTTGNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNA
P46940 Y43 Sugiyama IQGAP1 KIAA0051 NERLTAEEMDERRRQNVAyEyLCHLEEAKRWMEACLGEDLP
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P48741 T228 Sugiyama HSPA7 HSP70B DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR
P48741 Y43 Sugiyama HSPA7 HSP70B FQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAAL
P50395 S396 Sugiyama GDI2 RABGDIB IEQKFVsISDLLVPKDLGtEsQIFIsRTyDAttHFEttCDD
P52209 S126 Sugiyama PGD PGDH YRDTTRRCRDLKAKGILFVGsGVsGGEEGARyGPSLMPGGN
P52597 Y266 Sugiyama HNRNPF HNRPF ySGLSDGYGFTTDLFGRDLsyCLsGMyDHRYGDsEFtVQsT
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P54652 T229 Sugiyama HSPA2 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P54652 Y42 Sugiyama HSPA2 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P55795 Y266 Sugiyama HNRNPH2 FTP3 HNRPH2 YGGYNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGssFQst
P60709 S239 Sugiyama ACTB VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P60709 S368 Sugiyama ACTB sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709 Y198 Sugiyama ACTB LDLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCy
P60709 Y240 Sugiyama ACTB ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P60709 Y53 Sugiyama ACTB sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P60842 Y70 Sugiyama EIF4A1 DDX2A EIF4A yGFEKPsAIQQRAILPCIKGyDVIAQAQsGtGKTATFAISI
P61081 Y172 Sugiyama UBE2M UBC12 VLQNNRRLFEQNVQRSMRGGyIGstyFERCLK_________
P61247 S236 Sugiyama RPS3A FTE1 MFTL KMLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGy
P61247 S237 Sugiyama RPS3A FTE1 MFTL MLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGyE
P61981 Y49 Sugiyama YWHAG NVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSIEQK
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 Y49 Sugiyama YWHAE KVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssIEQK
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62736 S241 Sugiyama ACTA2 ACTSA ACTVS GIG46 VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P62736 Y242 Sugiyama ACTA2 ACTSA ACTVS GIG46 ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P62736 Y55 Sugiyama ACTA2 ACTSA ACTVS GIG46 sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P62826 T21 Sugiyama RAN ARA24 OK/SW-cl.81 MAAQGEPQVQFKLVLVGDGGtGKttFVKRHLtGEFEKKyVA
P63104 Y48 Sugiyama YWHAZ sVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssIEQK
P63261 S239 Sugiyama ACTG1 ACTG VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63261 S368 Sugiyama ACTG1 ACTG sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261 Y198 Sugiyama ACTG1 ACTG LDLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCy
P63261 Y240 Sugiyama ACTG1 ACTG ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P63261 Y53 Sugiyama ACTG1 ACTG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267 S240 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63267 Y241 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P63267 Y54 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68032 S241 Sugiyama ACTC1 ACTC VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68032 Y242 Sugiyama ACTC1 ACTC ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68032 Y55 Sugiyama ACTC1 ACTC sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68104 T261 Sugiyama EEF1A1 EEF1A EF1A LENG7 PTDKPLRLPLQDVyKIGGIGtVPVGRVEtGVLKPGMVVtFA
P68104 Y29 Sugiyama EEF1A1 EEF1A EF1A LENG7 NIVVIGHVDsGKstttGHLIyKCGGIDKRTIEKFEKEAAEM
P68133 S241 Sugiyama ACTA1 ACTA VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68133 Y242 Sugiyama ACTA1 ACTA ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68133 Y55 Sugiyama ACTA1 ACTA sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
Q00839 Y260 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 GDKKRGVKRPREDHGRGyFEyIEENKysRAKsPQPPVEEED
Q04917 Y49 Sugiyama YWHAH YWHA1 AVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSIEQK
Q05639 T261 Sugiyama EEF1A2 EEF1AL STN PTDKPLRLPLQDVyKIGGIGtVPVGRVETGILRPGMVVTFA
Q05639 Y29 Sugiyama EEF1A2 EEF1AL STN NIVVIGHVDsGKstttGHLIyKCGGIDKRTIEKFEKEAAEM
Q06830 Y116 Sugiyama PRDX1 PAGA PAGB TDPX2 GLGPMNIPLVSDPKRtIAQDyGVLKADEGIsFRGLFIIDDK
Q14240 Y71 Sugiyama EIF4A2 DDX2B EIF4F yGFEKPsAIQQRAIIPCIKGyDVIAQAQsGtGKTATFAISI
Q14568 Y283 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 sDEEEEKKDGDKKKKKTKEKyIDQEELNKTKPIWTRNPDDI
Q14677 S166 Sugiyama CLINT1 ENTH EPN4 EPNR KIAA0171 REERKKAKKNKDKyVGVssDsVGGFRysERYDPEPKSKWDE
Q15181 Y90 Sugiyama PPA1 IOPPP PP KQDVKKGKLRyVANLFPyKGyIWNyGAIPQtWEDPGHNDKH
Q15569 S220 SIGNOR|iPTMNet|EPSD TESK1 AEKIPVYREGARKEPLAVVGsPYWMAPEVLRGELYDEKADV
Q15569 S353 Sugiyama TESK1 QGSVARGGPSATLPRPDPRLsRsRSDLFLPPsPEsPPNWGD
Q15569 S355 Sugiyama TESK1 SVARGGPSATLPRPDPRLsRsRSDLFLPPsPEsPPNWGDNL
Q15569 S364 Sugiyama TESK1 TLPRPDPRLsRsRSDLFLPPsPEsPPNWGDNLTRVNPFSLR
Q15569 S367 Sugiyama TESK1 RPDPRLsRsRSDLFLPPsPEsPPNWGDNLTRVNPFSLREDL
Q15569 S437 Sugiyama TESK1 PLVTTPETLVQPGTPARRCRsLPssPELPRRMEtALPGPGP
Q15569 S440 Sugiyama TESK1 TTPETLVQPGTPARRCRsLPssPELPRRMEtALPGPGPPAV
Q15569 S441 Sugiyama TESK1 TPETLVQPGTPARRCRsLPssPELPRRMEtALPGPGPPAVG
Q15569 S46 Sugiyama TESK1 PGGTGGGPGRGRPSSYRALRsAVssLARVDDFHCAEKIGAG
Q15569 S49 Sugiyama TESK1 TGGGPGRGRPSSYRALRsAVssLARVDDFHCAEKIGAGFFS
Q15569 S50 Sugiyama TESK1 GGGPGRGRPSSYRALRsAVssLARVDDFHCAEKIGAGFFSE
Q15569 S603 Sugiyama TESK1 MCPRPTPAVARyRNLNCEAGsLLCHRGHHAKPPtPSLQLPG
Q15569 S626 Sugiyama TESK1 CHRGHHAKPPtPSLQLPGARs____________________
Q15569 S79 Sugiyama TESK1 CAEKIGAGFFSEVYKVRHRQsGQVMVLKMNKLPSNRGNtLR
Q15569 T450 Sugiyama TESK1 TPARRCRsLPssPELPRRMEtALPGPGPPAVGPSAEEKMEC
Q15569 T616 Sugiyama TESK1 NLNCEAGsLLCHRGHHAKPPtPSLQLPGARs__________
Q15569 T97 Sugiyama TESK1 RQsGQVMVLKMNKLPSNRGNtLREVQLMNRLRHPNILRFMG
Q15569 Y594 Sugiyama TESK1 GPFSFGFLSMCPRPTPAVARyRNLNCEAGsLLCHRGHHAKP
Q562R1 S240 Sugiyama ACTBL2 VALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPE
Q562R1 Y241 Sugiyama ACTBL2 ALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPEA
Q58FF8 Y198 Sugiyama HSP90AB2P HSP90BB DEEDDsGKDKKKKTKKIKEKyIDQEELNKTKPIWTRNTEDI
Q58FF8 Y260 Sugiyama HSP90AB2P HSP90BB VRYFSVEEYVSRMKEIQKsIyyItGEsKEQVANSAFVEQVW
Q58FF8 Y261 Sugiyama HSP90AB2P HSP90BB RYFSVEEYVSRMKEIQKsIyyItGEsKEQVANSAFVEQVWK
Q58FG0 Y177 Sugiyama HSP90AA5P HSP90AE GQLEELKDSRRVMKANQKHIyyItGETKDQVANSAFVECLQ
Q5VTE0 T261 Sugiyama EEF1A1P5 EEF1AL3 PTDKPLRLPLQDVyKIGGIGtVPVGRVEtGVLKPGMVVtFA
Q5VTE0 Y29 Sugiyama EEF1A1P5 EEF1AL3 NIVVIGHVDsGKstttGHLIyKCGGIDKRTIEKFEKEAAEM
Q6S8J3 S1068 Sugiyama POTEE A26C1A POTE2 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q6S8J3 S939 Sugiyama POTEE A26C1A POTE2 VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
Q6S8J3 Y940 Sugiyama POTEE A26C1A POTE2 ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
Q6ZMR3 S161 Sugiyama LDHAL6A LDHL2 DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q8N0Y7 Y92 Sugiyama PGAM4 PGAM3 DAIDQMWLPVVRTWRLNERHyGGLtGLNKAETAAKHGEAQV
Q92526 S246 Sugiyama CCT6B EDAFILICNVSLEYEKTEVNsGFFyKTAEEKEKLVKAERKF
Q9BYX7 S239 Sugiyama POTEKP ACTBL3 FKSG30 VALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPE
Q9BYX7 S368 Sugiyama POTEKP ACTBL3 FKSG30 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9BYX7 Y240 Sugiyama POTEKP ACTBL3 FKSG30 ALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPEA
Q9HAP6 Y118 Sugiyama LIN7B MALS2 VELI2 UNQ3116/PRO10200 KTDEGLGFNIMGGKEQNsPIyIsRVIPGGVADRHGGLKRGD
Q9NUP9 Y118 Sugiyama LIN7C MALS3 VELI3 KTEEGLGFNIMGGKEQNsPIyIsRIIPGGIADRHGGLKRGD
Q9Y281 S3 SIGNOR CFL2 __________________MAsGVtVNDEVIKVFNDMKVRKs
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Signaling by ALK fusions and activated point mutants R-HSA-9725370 6.039202e-09 8.219 0 0
Signaling by ALK in cancer R-HSA-9700206 6.039202e-09 8.219 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 9.021649e-07 6.045 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 2.394933e-06 5.621 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 3.921328e-05 4.407 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 6.280095e-05 4.202 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.074901e-04 3.969 0 0
GPVI-mediated activation cascade R-HSA-114604 9.661782e-05 4.015 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.168199e-04 3.932 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.937816e-04 3.713 0 0
Interleukin-2 signaling R-HSA-9020558 4.503290e-04 3.346 0 0
Signaling by Interleukins R-HSA-449147 4.345144e-04 3.362 0 0
Signaling by Erythropoietin R-HSA-9006335 5.261728e-04 3.279 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 5.261728e-04 3.279 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 5.842336e-04 3.233 0 0
DAP12 signaling R-HSA-2424491 5.842336e-04 3.233 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 6.620909e-04 3.179 0 0
Signaling by LTK R-HSA-9842663 6.620909e-04 3.179 0 0
Signaling by ERBB2 R-HSA-1227986 7.766865e-04 3.110 0 0
Signal Transduction R-HSA-162582 7.638715e-04 3.117 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 9.443433e-04 3.025 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 9.443433e-04 3.025 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 9.991541e-04 3.000 0 0
Erythropoietin activates RAS R-HSA-9027284 1.083798e-03 2.965 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.085478e-03 2.964 0 0
RUNX2 regulates bone development R-HSA-8941326 1.124406e-03 2.949 0 0
Parasite infection R-HSA-9664407 1.367377e-03 2.864 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 1.367377e-03 2.864 0 0
Leishmania phagocytosis R-HSA-9664417 1.367377e-03 2.864 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 1.417347e-03 2.849 0 0
Interleukin-2 family signaling R-HSA-451927 1.554404e-03 2.808 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 1.847254e-03 2.733 0 0
FCERI mediated MAPK activation R-HSA-2871796 2.000186e-03 2.699 0 0
Regulation of signaling by CBL R-HSA-912631 2.103306e-03 2.677 0 0
DAP12 interactions R-HSA-2172127 2.238025e-03 2.650 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.431166e-03 2.614 0 0
Signaling by ROBO receptors R-HSA-376176 2.388321e-03 2.622 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 2.497291e-03 2.603 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 2.561570e-03 2.591 0 0
Apoptotic execution phase R-HSA-75153 2.561570e-03 2.591 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 2.823492e-03 2.549 0 0
SARS-CoV Infections R-HSA-9679506 2.886611e-03 2.540 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 2.927709e-03 2.533 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 3.239698e-03 2.489 0 0
Signaling by VEGF R-HSA-194138 3.621767e-03 2.441 0 0
Translation initiation complex formation R-HSA-72649 4.176974e-03 2.379 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 4.667855e-03 2.331 0 0
Signaling by EGFR R-HSA-177929 4.667855e-03 2.331 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 5.196134e-03 2.284 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 5.546112e-03 2.256 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 6.001761e-03 2.222 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 6.061364e-03 2.217 0 0
mRNA Splicing - Major Pathway R-HSA-72163 7.178429e-03 2.144 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 7.513833e-03 2.124 0 0
IGF1R signaling cascade R-HSA-2428924 7.017526e-03 2.154 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 7.357120e-03 2.133 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 7.513833e-03 2.124 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 8.269985e-03 2.082 0 0
Signal attenuation R-HSA-74749 8.269985e-03 2.082 0 0
Metabolism of RNA R-HSA-8953854 8.010463e-03 2.096 0 0
SARS-CoV-1-host interactions R-HSA-9692914 8.102385e-03 2.091 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.031747e-02 1.986 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.031747e-02 1.986 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.031747e-02 1.986 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.031747e-02 1.986 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.031747e-02 1.986 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.031747e-02 1.986 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 9.526648e-03 2.021 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 9.526648e-03 2.021 0 0
mRNA Splicing R-HSA-72172 9.302496e-03 2.031 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.885757e-03 2.051 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 9.032883e-03 2.044 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 9.526648e-03 2.021 0 0
ChREBP activates metabolic gene expression R-HSA-163765 9.526648e-03 2.021 0 0
Cytokine Signaling in Immune system R-HSA-1280215 9.982187e-03 2.001 0 0
Disease R-HSA-1643685 1.005346e-02 1.998 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 1.086263e-02 1.964 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 1.156575e-02 1.937 0 0
Signaling by TGFB family members R-HSA-9006936 1.113490e-02 1.953 0 0
p75NTR recruits signalling complexes R-HSA-209543 1.227618e-02 1.911 0 0
Translation of Structural Proteins R-HSA-9694635 1.230081e-02 1.910 0 0
Signaling by ALK R-HSA-201556 1.255398e-02 1.901 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.456073e-02 1.837 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 1.532914e-02 1.814 0 0
Leishmania infection R-HSA-9658195 1.383956e-02 1.859 0 0
Parasitic Infection Pathways R-HSA-9824443 1.383956e-02 1.859 0 0
Signaling by FGFR2 R-HSA-5654738 1.380149e-02 1.860 0 0
Signal regulatory protein family interactions R-HSA-391160 1.532914e-02 1.814 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.487981e-02 1.827 0 0
Interleukin-10 signaling R-HSA-6783783 1.278880e-02 1.893 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 1.532914e-02 1.814 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.633736e-02 1.787 0 0
SARS-CoV-2 Infection R-HSA-9694516 1.545903e-02 1.811 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 1.648243e-02 1.783 0 0
Signaling by FGFR4 R-HSA-5654743 1.648243e-02 1.783 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.696517e-02 1.770 0 0
p75NTR signals via NF-kB R-HSA-193639 1.696517e-02 1.770 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.822515e-02 1.739 0 0
Signaling by FGFR3 R-HSA-5654741 1.822515e-02 1.739 0 0
Immune System R-HSA-168256 1.854347e-02 1.732 0 0
GPER1 signaling R-HSA-9634597 2.102421e-02 1.677 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 2.302494e-02 1.638 0 0
Signaling by Hippo R-HSA-2028269 2.229185e-02 1.652 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 2.164588e-02 1.665 0 0
Glycogen storage diseases R-HSA-3229121 2.229185e-02 1.652 0 0
Polo-like kinase mediated events R-HSA-156711 2.420163e-02 1.616 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 2.420163e-02 1.616 0 0
Cell-Cell communication R-HSA-1500931 2.475557e-02 1.606 1 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 2.348919e-02 1.629 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 2.231780e-02 1.651 0 0
Formation of a pool of free 40S subunits R-HSA-72689 2.522771e-02 1.598 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 3.031204e-02 1.518 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 3.031204e-02 1.518 0 0
Negative regulation of MET activity R-HSA-6807004 2.821323e-02 1.550 0 0
Other interleukin signaling R-HSA-449836 2.617593e-02 1.582 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 2.598924e-02 1.585 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 3.031204e-02 1.518 0 0
Glycogen synthesis R-HSA-3322077 2.821323e-02 1.550 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 3.031204e-02 1.518 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 3.031204e-02 1.518 0 0
Signaling by FGFR R-HSA-190236 2.755348e-02 1.560 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.821323e-02 1.550 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 2.728984e-02 1.564 0 0
Signaling by FGFR1 R-HSA-5654736 2.957580e-02 1.529 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.835627e-02 1.547 0 0
Signaling by NTRKs R-HSA-166520 3.023375e-02 1.520 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 3.000338e-02 1.523 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 3.031204e-02 1.518 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 3.063602e-02 1.514 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 3.063602e-02 1.514 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 3.063602e-02 1.514 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 3.063602e-02 1.514 0 0
Inhibition of membrane repair R-HSA-9635644 3.063602e-02 1.514 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 3.247089e-02 1.489 0 0
Signaling by PDGFR in disease R-HSA-9671555 3.247089e-02 1.489 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 3.247089e-02 1.489 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 3.247089e-02 1.489 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 4.063925e-02 1.391 0 0
Glycogen storage disease type IV (GBE1) R-HSA-3878781 4.063925e-02 1.391 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 4.063925e-02 1.391 0 0
Interleukin receptor SHC signaling R-HSA-912526 3.696294e-02 1.432 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 3.929332e-02 1.406 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 3.714954e-02 1.430 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 4.105931e-02 1.387 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 4.105931e-02 1.387 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 3.734851e-02 1.428 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 4.063925e-02 1.391 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 3.468833e-02 1.460 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 3.737107e-02 1.427 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 3.714954e-02 1.430 0 0
Interferon gamma signaling R-HSA-877300 3.813696e-02 1.419 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 3.468833e-02 1.460 0 0
Death Receptor Signaling R-HSA-73887 3.440282e-02 1.463 0 0
Growth hormone receptor signaling R-HSA-982772 3.696294e-02 1.432 0 0
Axon guidance R-HSA-422475 3.471966e-02 1.459 0 0
Apoptosis R-HSA-109581 4.049219e-02 1.393 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 4.167809e-02 1.380 0 0
RAF/MAP kinase cascade R-HSA-5673001 4.324970e-02 1.364 0 0
Signaling by EGFR in Cancer R-HSA-1643713 4.411589e-02 1.355 0 0
Suppression of phagosomal maturation R-HSA-9637687 4.411589e-02 1.355 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 4.626303e-02 1.335 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 4.660540e-02 1.332 0 0
Cristae formation R-HSA-8949613 4.660540e-02 1.332 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 4.660540e-02 1.332 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 4.660540e-02 1.332 0 0
Cap-dependent Translation Initiation R-HSA-72737 4.734594e-02 1.325 0 0
Eukaryotic Translation Initiation R-HSA-72613 4.734594e-02 1.325 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 4.772138e-02 1.321 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 4.829147e-02 1.316 0 0
rRNA processing R-HSA-72312 4.863129e-02 1.313 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 4.914529e-02 1.309 0 0
Nervous system development R-HSA-9675108 5.055601e-02 1.296 0 0
Ub-specific processing proteases R-HSA-5689880 5.078362e-02 1.294 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 5.134327e-02 1.290 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 5.173429e-02 1.286 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 5.173429e-02 1.286 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 5.290354e-02 1.277 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 5.437111e-02 1.265 0 0
Interleukin-37 signaling R-HSA-9008059 5.437111e-02 1.265 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 6.033892e-02 1.219 0 0
IRS activation R-HSA-74713 7.003744e-02 1.155 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 7.003744e-02 1.155 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 7.003744e-02 1.155 0 0
Regulation of gap junction activity R-HSA-191650 6.033892e-02 1.219 0 0
Budding and maturation of HIV virion R-HSA-162588 5.705451e-02 1.244 0 0
Deubiquitination R-HSA-5688426 6.805330e-02 1.167 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 6.033892e-02 1.219 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 7.003744e-02 1.155 0 0
EGFR downregulation R-HSA-182971 5.705451e-02 1.244 0 0
Nuclear RNA decay R-HSA-9930044 6.255616e-02 1.204 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 5.609208e-02 1.251 0 0
RET signaling R-HSA-8853659 7.406567e-02 1.130 0 0
Mitophagy R-HSA-5205647 6.822964e-02 1.166 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 6.033892e-02 1.219 0 0
Co-inhibition by BTLA R-HSA-9927353 7.003744e-02 1.155 0 0
Integrin signaling R-HSA-354192 6.255616e-02 1.204 0 0
Innate Immune System R-HSA-168249 6.768913e-02 1.169 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 7.112790e-02 1.148 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 7.112790e-02 1.148 0 0
Signaling by MET R-HSA-6806834 6.445267e-02 1.191 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 7.112790e-02 1.148 0 0
G0 and Early G1 R-HSA-1538133 5.978326e-02 1.223 0 0
Voltage gated Potassium channels R-HSA-1296072 7.704183e-02 1.113 0 0
Ovarian tumor domain proteases R-HSA-5689896 7.704183e-02 1.113 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 7.963645e-02 1.099 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 7.963645e-02 1.099 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 7.963645e-02 1.099 0 0
Erythropoietin activates STAT5 R-HSA-9027283 8.913696e-02 1.050 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 9.853999e-02 1.006 0 0
SOS-mediated signalling R-HSA-112412 9.853999e-02 1.006 0 0
DAG1 core M1 glycosylations R-HSA-8932506 9.853999e-02 1.006 0 0
DAG1 core M2 glycosylations R-HSA-8932504 1.078465e-01 0.967 0 0
DAG1 core M3 glycosylations R-HSA-8932505 1.351970e-01 0.869 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 1.529659e-01 0.815 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 1.789410e-01 0.747 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 1.789410e-01 0.747 0 0
SHC1 events in EGFR signaling R-HSA-180336 1.789410e-01 0.747 0 0
Translesion synthesis by POLI R-HSA-5656121 1.874223e-01 0.727 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 1.958164e-01 0.708 0 0
Translesion synthesis by POLK R-HSA-5655862 1.958164e-01 0.708 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.204850e-01 0.657 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 2.285396e-01 0.641 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 2.285396e-01 0.641 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 2.285396e-01 0.641 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 2.285396e-01 0.641 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 2.285396e-01 0.641 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 8.667228e-02 1.062 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 8.865371e-02 1.052 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 9.676753e-02 1.014 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.756670e-01 0.755 0 0
Viral mRNA Translation R-HSA-192823 1.160650e-01 0.935 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 1.273623e-01 0.895 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.123469e-01 0.673 0 0
Formation of definitive endoderm R-HSA-9823730 2.285396e-01 0.641 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 1.053803e-01 0.977 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 1.053803e-01 0.977 0 0
Translesion Synthesis by POLH R-HSA-110320 2.204850e-01 0.657 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 1.261740e-01 0.899 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 1.789410e-01 0.747 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 1.170575e-01 0.932 0 0
PI3K/AKT activation R-HSA-198203 1.261740e-01 0.899 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 1.703719e-01 0.769 0 0
Translesion synthesis by REV1 R-HSA-110312 1.789410e-01 0.747 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 1.290427e-01 0.889 0 0
Peptide chain elongation R-HSA-156902 8.084418e-02 1.092 0 0
Ribosome-associated quality control R-HSA-9948299 2.180771e-01 0.661 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.585914e-02 1.018 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 1.617138e-01 0.791 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 1.255893e-01 0.901 0 0
Insulin receptor signalling cascade R-HSA-74751 1.719858e-01 0.765 0 0
Neutrophil degranulation R-HSA-6798695 1.257642e-01 0.900 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 1.078465e-01 0.967 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 1.441273e-01 0.841 0 0
CD28 dependent Vav1 pathway R-HSA-389359 1.617138e-01 0.791 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 2.204850e-01 0.657 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.529659e-01 0.815 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 1.703719e-01 0.769 0 0
Eukaryotic Translation Termination R-HSA-72764 9.884194e-02 1.005 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.261740e-01 0.899 0 0
Complex IV assembly R-HSA-9864848 1.255893e-01 0.901 0 0
Germ layer formation at gastrulation R-HSA-9754189 2.204850e-01 0.657 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 7.963645e-02 1.099 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 7.963645e-02 1.099 0 0
Regulation of PTEN localization R-HSA-8948747 9.853999e-02 1.006 0 0
Disinhibition of SNARE formation R-HSA-114516 9.853999e-02 1.006 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 1.078465e-01 0.967 0 0
Josephin domain DUBs R-HSA-5689877 1.261740e-01 0.899 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 1.261740e-01 0.899 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.529659e-01 0.815 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 2.041243e-01 0.690 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.123469e-01 0.673 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.471129e-02 1.024 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.123469e-01 0.673 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.830665e-01 0.737 0 0
Clathrin-mediated endocytosis R-HSA-8856828 2.343582e-01 0.630 0 0
Cellular response to hypoxia R-HSA-1234174 1.756670e-01 0.755 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 1.958164e-01 0.708 0 0
Eukaryotic Translation Elongation R-HSA-156842 9.065417e-02 1.043 0 0
NRIF signals cell death from the nucleus R-HSA-205043 1.703719e-01 0.769 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.683178e-01 0.774 0 0
Dectin-2 family R-HSA-5621480 1.466257e-01 0.834 0 0
Selective autophagy R-HSA-9663891 8.084418e-02 1.092 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.078465e-01 0.967 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 1.351970e-01 0.869 0 0
MET activates RAS signaling R-HSA-8851805 1.529659e-01 0.815 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.086831e-01 0.964 0 0
Interleukin-15 signaling R-HSA-8983432 1.529659e-01 0.815 0 0
TNF signaling R-HSA-75893 1.430697e-01 0.844 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 7.963645e-02 1.099 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 1.529659e-01 0.815 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 1.529659e-01 0.815 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.789410e-01 0.747 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 1.789410e-01 0.747 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 2.204850e-01 0.657 0 0
Signaling by NODAL R-HSA-1181150 2.285396e-01 0.641 0 0
Macroautophagy R-HSA-1632852 2.261887e-01 0.646 0 0
Regulation of CDH1 Function R-HSA-9764561 1.466257e-01 0.834 0 0
Signaling by Activin R-HSA-1502540 1.789410e-01 0.747 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.244421e-01 0.649 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 8.913696e-02 1.050 0 0
Selenocysteine synthesis R-HSA-2408557 1.116577e-01 0.952 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.438041e-01 0.842 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 1.441273e-01 0.841 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 1.958164e-01 0.708 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.123469e-01 0.673 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 1.364912e-01 0.865 0 0
VEGF ligand-receptor interactions R-HSA-194313 7.963645e-02 1.099 0 0
NF-kB is activated and signals survival R-HSA-209560 1.441273e-01 0.841 0 0
Regulation of IFNG signaling R-HSA-877312 1.529659e-01 0.815 0 0
VLDLR internalisation and degradation R-HSA-8866427 1.529659e-01 0.815 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 1.529659e-01 0.815 0 0
IRAK1 recruits IKK complex R-HSA-937039 1.529659e-01 0.815 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.529659e-01 0.815 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 1.617138e-01 0.791 0 0
Synthesis of 15-eicosatetraenoic acid derivatives R-HSA-2142770 2.041243e-01 0.690 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 1.182930e-01 0.927 0 0
Homology Directed Repair R-HSA-5693538 1.584244e-01 0.800 0 0
Generation of second messenger molecules R-HSA-202433 8.618980e-02 1.065 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.041243e-01 0.690 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.041243e-01 0.690 0 0
Amyloid fiber formation R-HSA-977225 2.358625e-01 0.627 0 0
TCR signaling R-HSA-202403 1.343231e-01 0.872 0 0
Generic Transcription Pathway R-HSA-212436 9.198827e-02 1.036 0 0
Maturation of protein E R-HSA-9694493 7.963645e-02 1.099 0 0
Maturation of protein E R-HSA-9683683 7.963645e-02 1.099 0 0
Lipophagy R-HSA-9613354 1.170575e-01 0.932 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.351970e-01 0.869 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 1.958164e-01 0.708 0 0
Synthesis of PG R-HSA-1483148 1.958164e-01 0.708 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 8.930876e-02 1.049 0 0
RNA Polymerase II Transcription R-HSA-73857 1.204853e-01 0.919 0 0
MAP kinase activation R-HSA-450294 1.610241e-01 0.793 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.789410e-01 0.747 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 1.874223e-01 0.727 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 1.958164e-01 0.708 0 0
Signal transduction by L1 R-HSA-445144 2.285396e-01 0.641 0 0
Interleukin-17 signaling R-HSA-448424 1.942487e-01 0.712 0 0
Modulation by Mtb of host immune system R-HSA-9637628 1.078465e-01 0.967 0 0
Physiological factors R-HSA-5578768 1.703719e-01 0.769 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 1.874223e-01 0.727 0 0
Creatine metabolism R-HSA-71288 2.285396e-01 0.641 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.320515e-01 0.634 0 0
Pexophagy R-HSA-9664873 1.261740e-01 0.899 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 8.930876e-02 1.049 0 0
Nephrin family interactions R-HSA-373753 2.285396e-01 0.641 0 0
Interleukin-1 family signaling R-HSA-446652 1.018097e-01 0.992 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.170575e-01 0.932 0 0
PECAM1 interactions R-HSA-210990 1.351970e-01 0.869 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.789410e-01 0.747 0 0
Maturation of nucleoprotein R-HSA-9694631 2.204850e-01 0.657 0 0
NRAGE signals death through JNK R-HSA-193648 1.430697e-01 0.844 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 1.709424e-01 0.767 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.182930e-01 0.927 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 2.055161e-01 0.687 0 0
Glycogen metabolism R-HSA-8982491 8.618980e-02 1.065 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.078465e-01 0.967 0 0
Regulation of KIT signaling R-HSA-1433559 1.703719e-01 0.769 0 0
Regulation of BACH1 activity R-HSA-9708530 1.874223e-01 0.727 0 0
Cyclin D associated events in G1 R-HSA-69231 1.021057e-01 0.991 0 0
G1 Phase R-HSA-69236 1.021057e-01 0.991 0 0
FOXO-mediated transcription R-HSA-9614085 1.073169e-01 0.969 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 2.017518e-01 0.695 0 0
Signaling by ERBB4 R-HSA-1236394 2.092880e-01 0.679 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.438041e-01 0.842 0 0
MAPK family signaling cascades R-HSA-5683057 8.908080e-02 1.050 0 0
HDL assembly R-HSA-8963896 1.703719e-01 0.769 0 0
Platelet sensitization by LDL R-HSA-432142 2.123469e-01 0.673 0 0
Signaling by NOTCH3 R-HSA-9012852 1.395326e-01 0.855 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.863231e-01 0.730 0 0
Signaling by Leptin R-HSA-2586552 1.261740e-01 0.899 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.537915e-01 0.813 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.078465e-01 0.967 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.170575e-01 0.932 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.886027e-02 1.005 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 1.915293e-01 0.718 0 0
G1/S Transition R-HSA-69206 1.785864e-01 0.748 0 0
Programmed Cell Death R-HSA-5357801 8.629723e-02 1.064 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.170887e-01 0.931 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 9.231102e-02 1.035 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 1.486262e-01 0.828 0 0
Hemostasis R-HSA-109582 2.155232e-01 0.667 0 0
Negative regulation of FLT3 R-HSA-9706369 1.874223e-01 0.727 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 2.123469e-01 0.673 0 0
Maturation of spike protein R-HSA-9694548 8.930876e-02 1.049 0 0
DNA Double Strand Break Response R-HSA-5693606 1.830665e-01 0.737 0 0
Mitochondrial biogenesis R-HSA-1592230 1.559562e-01 0.807 0 0
Cellular response to chemical stress R-HSA-9711123 1.809782e-01 0.742 0 0
Signaling by SCF-KIT R-HSA-1433557 9.886027e-02 1.005 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.646637e-01 0.783 0 0
Tie2 Signaling R-HSA-210993 2.123469e-01 0.673 0 0
G alpha (12/13) signalling events R-HSA-416482 2.244421e-01 0.649 0 0
Cell-cell junction organization R-HSA-421270 1.523694e-01 0.817 0 0
Infectious disease R-HSA-5663205 1.722624e-01 0.764 0 0
Adherens junctions interactions R-HSA-418990 2.348074e-01 0.629 0 0
Azathioprine ADME R-HSA-9748787 1.221587e-01 0.913 0 0
Cell junction organization R-HSA-446728 1.986819e-01 0.702 1 0
Uptake and function of anthrax toxins R-HSA-5210891 2.041243e-01 0.690 0 0
Viral Infection Pathways R-HSA-9824446 2.124708e-01 0.673 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 1.617138e-01 0.791 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.584244e-01 0.800 0 0
FLT3 Signaling R-HSA-9607240 8.930876e-02 1.049 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 2.041243e-01 0.690 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 2.055161e-01 0.687 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 1.703719e-01 0.769 0 0
Integrin cell surface interactions R-HSA-216083 2.244421e-01 0.649 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 2.204850e-01 0.657 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 2.365114e-01 0.626 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 2.365114e-01 0.626 0 0
Signalling to RAS R-HSA-167044 2.365114e-01 0.626 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 2.365114e-01 0.626 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 2.365114e-01 0.626 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 2.365114e-01 0.626 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.415190e-01 0.617 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 2.434914e-01 0.614 0 0
Interferon Signaling R-HSA-913531 2.434914e-01 0.614 0 0
Cytoprotection by HMOX1 R-HSA-9707564 2.434947e-01 0.614 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 2.444014e-01 0.612 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 2.444014e-01 0.612 0 0
Assembly Of The HIV Virion R-HSA-175474 2.444014e-01 0.612 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 2.444014e-01 0.612 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 2.473150e-01 0.607 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 2.480881e-01 0.605 0 0
S Phase R-HSA-69242 2.480881e-01 0.605 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.511374e-01 0.600 0 0
FGFR2 alternative splicing R-HSA-6803529 2.522103e-01 0.598 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 2.522103e-01 0.598 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 2.522103e-01 0.598 0 0
Potential therapeutics for SARS R-HSA-9679191 2.536154e-01 0.596 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.549615e-01 0.594 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.549615e-01 0.594 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 2.549615e-01 0.594 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 2.563858e-01 0.591 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.587869e-01 0.587 0 0
XBP1(S) activates chaperone genes R-HSA-381038 2.587869e-01 0.587 0 0
Carnitine shuttle R-HSA-200425 2.599389e-01 0.585 0 0
DNA Double-Strand Break Repair R-HSA-5693532 2.619393e-01 0.582 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 2.675084e-01 0.573 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 2.675882e-01 0.573 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 2.675882e-01 0.573 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.675882e-01 0.573 0 0
Deadenylation of mRNA R-HSA-429947 2.675882e-01 0.573 0 0
Complex III assembly R-HSA-9865881 2.675882e-01 0.573 0 0
Plasma lipoprotein assembly R-HSA-8963898 2.675882e-01 0.573 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.675882e-01 0.573 0 0
Neurodegenerative Diseases R-HSA-8863678 2.675882e-01 0.573 0 0
Autophagy R-HSA-9612973 2.702983e-01 0.568 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 2.751588e-01 0.560 0 0
Tight junction interactions R-HSA-420029 2.751588e-01 0.560 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 2.751588e-01 0.560 0 0
TGFBR3 expression R-HSA-9839394 2.751588e-01 0.560 0 0
Interleukin-7 signaling R-HSA-1266695 2.751588e-01 0.560 0 0
Cellular response to starvation R-HSA-9711097 2.758880e-01 0.559 0 0
ESR-mediated signaling R-HSA-8939211 2.776696e-01 0.556 0 0
IRE1alpha activates chaperones R-HSA-381070 2.817424e-01 0.550 0 0
Metalloprotease DUBs R-HSA-5689901 2.826517e-01 0.549 0 0
Myogenesis R-HSA-525793 2.826517e-01 0.549 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 2.826517e-01 0.549 0 0
Signaling by Insulin receptor R-HSA-74752 2.855651e-01 0.544 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 2.855651e-01 0.544 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 2.900676e-01 0.538 0 0
Signaling by BMP R-HSA-201451 2.900676e-01 0.538 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 2.900676e-01 0.538 0 0
Triglyceride biosynthesis R-HSA-75109 2.900676e-01 0.538 0 0
Synthesis of PE R-HSA-1483213 2.900676e-01 0.538 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 2.900676e-01 0.538 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 2.900676e-01 0.538 0 0
Separation of Sister Chromatids R-HSA-2467813 2.927231e-01 0.534 0 0
Selenoamino acid metabolism R-HSA-2408522 2.927231e-01 0.534 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 2.974073e-01 0.527 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 2.974073e-01 0.527 0 0
Extracellular matrix organization R-HSA-1474244 3.004774e-01 0.522 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 3.046422e-01 0.516 0 0
Potassium Channels R-HSA-1296071 3.046422e-01 0.516 0 0
Late endosomal microautophagy R-HSA-9615710 3.046715e-01 0.516 0 0
Termination of translesion DNA synthesis R-HSA-5656169 3.046715e-01 0.516 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 3.046715e-01 0.516 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 3.046715e-01 0.516 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 3.046715e-01 0.516 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 3.084480e-01 0.511 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 3.118611e-01 0.506 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 3.118611e-01 0.506 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 3.118611e-01 0.506 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 3.122497e-01 0.505 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 3.122497e-01 0.505 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 3.122497e-01 0.505 0 0
Adaptive Immune System R-HSA-1280218 3.148704e-01 0.502 0 0
G alpha (s) signalling events R-HSA-418555 3.152724e-01 0.501 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 3.189767e-01 0.496 0 0
Downstream signal transduction R-HSA-186763 3.189767e-01 0.496 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 3.189767e-01 0.496 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 3.189767e-01 0.496 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 3.189767e-01 0.496 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 3.189767e-01 0.496 0 0
Mitotic Spindle Checkpoint R-HSA-69618 3.198398e-01 0.495 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 3.206837e-01 0.494 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 3.209191e-01 0.494 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 3.209191e-01 0.494 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 3.216833e-01 0.493 0 0
Gene expression (Transcription) R-HSA-74160 3.222133e-01 0.492 0 0
Intracellular signaling by second messengers R-HSA-9006925 3.227141e-01 0.491 0 0
Interleukin-1 signaling R-HSA-9020702 3.236275e-01 0.490 0 0
Cellular responses to stimuli R-HSA-8953897 3.244951e-01 0.489 0 0
DAG1 glycosylations R-HSA-8931838 3.260193e-01 0.487 0 0
Cell Cycle Checkpoints R-HSA-69620 3.263557e-01 0.486 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 3.274100e-01 0.485 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 3.329894e-01 0.478 0 0
FGFR1 mutant receptor activation R-HSA-1839124 3.329894e-01 0.478 0 0
Regulation of necroptotic cell death R-HSA-5675482 3.329894e-01 0.478 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 3.329894e-01 0.478 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 3.329894e-01 0.478 0 0
Activation of ATR in response to replication stress R-HSA-176187 3.329894e-01 0.478 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 3.329894e-01 0.478 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 3.329894e-01 0.478 0 0
Cardiogenesis R-HSA-9733709 3.329894e-01 0.478 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 3.349580e-01 0.475 0 0
Respiratory electron transport R-HSA-611105 3.350388e-01 0.475 0 0
Influenza Infection R-HSA-168255 3.378620e-01 0.471 0 0
Resolution of D-Loop Structures R-HSA-5693537 3.398879e-01 0.469 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 3.398879e-01 0.469 0 0
Vpu mediated degradation of CD4 R-HSA-180534 3.398879e-01 0.469 0 0
Miscellaneous transport and binding events R-HSA-5223345 3.398879e-01 0.469 0 0
Effects of PIP2 hydrolysis R-HSA-114508 3.398879e-01 0.469 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 3.398879e-01 0.469 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 3.398879e-01 0.469 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 3.424816e-01 0.465 0 0
Dual Incision in GG-NER R-HSA-5696400 3.467155e-01 0.460 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 3.467155e-01 0.460 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 3.467155e-01 0.460 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 3.467155e-01 0.460 0 0
NOD1/2 Signaling Pathway R-HSA-168638 3.467155e-01 0.460 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 3.467155e-01 0.460 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 3.467155e-01 0.460 0 0
Calnexin/calreticulin cycle R-HSA-901042 3.467155e-01 0.460 0 0
Signaling by NOTCH2 R-HSA-1980145 3.467155e-01 0.460 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 3.534728e-01 0.452 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 3.534728e-01 0.452 0 0
Regulation of Apoptosis R-HSA-169911 3.534728e-01 0.452 0 0
Signalling to ERKs R-HSA-187687 3.534728e-01 0.452 0 0
Oncogene Induced Senescence R-HSA-2559585 3.534728e-01 0.452 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 3.537164e-01 0.451 0 0
Stimuli-sensing channels R-HSA-2672351 3.537164e-01 0.451 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 3.574467e-01 0.447 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 3.574467e-01 0.447 0 0
G2/M Transition R-HSA-69275 3.575996e-01 0.447 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 3.601607e-01 0.444 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 3.601607e-01 0.444 0 0
Regulation of TP53 Degradation R-HSA-6804757 3.601607e-01 0.444 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 3.601607e-01 0.444 0 0
Calmodulin induced events R-HSA-111933 3.601607e-01 0.444 0 0
CaM pathway R-HSA-111997 3.601607e-01 0.444 0 0
G1/S-Specific Transcription R-HSA-69205 3.601607e-01 0.444 0 0
FLT3 signaling in disease R-HSA-9682385 3.601607e-01 0.444 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 3.611694e-01 0.442 0 0
MyD88-independent TLR4 cascade R-HSA-166166 3.611694e-01 0.442 0 0
Mitotic G2-G2/M phases R-HSA-453274 3.632268e-01 0.440 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 3.667798e-01 0.436 0 0
Degradation of DVL R-HSA-4641258 3.667798e-01 0.436 0 0
Degradation of AXIN R-HSA-4641257 3.667798e-01 0.436 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 3.667798e-01 0.436 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.667798e-01 0.436 0 0
Toll-like Receptor Cascades R-HSA-168898 3.716535e-01 0.430 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 3.722892e-01 0.429 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 3.733308e-01 0.428 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 3.733308e-01 0.428 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 3.733308e-01 0.428 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 3.798145e-01 0.420 0 0
Stabilization of p53 R-HSA-69541 3.798145e-01 0.420 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 3.798145e-01 0.420 0 0
RAS processing R-HSA-9648002 3.798145e-01 0.420 0 0
Plasma lipoprotein clearance R-HSA-8964043 3.798145e-01 0.420 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 3.833316e-01 0.416 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 3.856517e-01 0.414 0 0
Aggrephagy R-HSA-9646399 3.862315e-01 0.413 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 3.862315e-01 0.413 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 3.862315e-01 0.413 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 3.862315e-01 0.413 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 3.862315e-01 0.413 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 3.862315e-01 0.413 0 0
Interferon alpha/beta signaling R-HSA-909733 3.869942e-01 0.412 0 0
Membrane Trafficking R-HSA-199991 3.918319e-01 0.407 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 3.925825e-01 0.406 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 3.925825e-01 0.406 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 3.925825e-01 0.406 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 3.925825e-01 0.406 0 0
Co-inhibition by PD-1 R-HSA-389948 3.967998e-01 0.401 0 0
MAP2K and MAPK activation R-HSA-5674135 3.988681e-01 0.399 0 0
Degradation of CRY and PER proteins R-HSA-9932298 3.988681e-01 0.399 0 0
Signaling by RAF1 mutants R-HSA-9656223 3.988681e-01 0.399 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.988681e-01 0.399 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 3.988681e-01 0.399 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 3.988681e-01 0.399 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 3.988681e-01 0.399 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 3.988681e-01 0.399 0 0
Negative regulation of MAPK pathway R-HSA-5675221 3.988681e-01 0.399 0 0
Translation of Structural Proteins R-HSA-9683701 3.988681e-01 0.399 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 4.015485e-01 0.396 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 4.015485e-01 0.396 0 0
MTOR signalling R-HSA-165159 4.050891e-01 0.392 0 0
Ca-dependent events R-HSA-111996 4.050891e-01 0.392 0 0
Cell Cycle, Mitotic R-HSA-69278 4.080140e-01 0.389 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 4.087653e-01 0.389 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 4.087653e-01 0.389 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 4.112461e-01 0.386 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 4.123580e-01 0.385 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 4.123580e-01 0.385 0 0
PIP3 activates AKT signaling R-HSA-1257604 4.128929e-01 0.384 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 4.159400e-01 0.381 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 4.173397e-01 0.380 0 0
RMTs methylate histone arginines R-HSA-3214858 4.173397e-01 0.380 0 0
Formation of the cornified envelope R-HSA-6809371 4.195112e-01 0.377 0 0
Fanconi Anemia Pathway R-HSA-6783310 4.233707e-01 0.373 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 4.233707e-01 0.373 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 4.233707e-01 0.373 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 4.233707e-01 0.373 0 0
DAG and IP3 signaling R-HSA-1489509 4.233707e-01 0.373 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 4.293396e-01 0.367 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 4.293396e-01 0.367 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 4.293396e-01 0.367 0 0
Signaling downstream of RAS mutants R-HSA-9649948 4.293396e-01 0.367 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 4.293396e-01 0.367 0 0
Signaling by RAS mutants R-HSA-6802949 4.293396e-01 0.367 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 4.293396e-01 0.367 0 0
Regulation of pyruvate metabolism R-HSA-9861718 4.293396e-01 0.367 0 0
Diseases of DNA repair R-HSA-9675135 4.293396e-01 0.367 0 0
Signaling by TGFBR3 R-HSA-9839373 4.293396e-01 0.367 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 4.301580e-01 0.366 0 0
Muscle contraction R-HSA-397014 4.326286e-01 0.364 0 0
G2/M Checkpoints R-HSA-69481 4.336841e-01 0.363 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 4.352471e-01 0.361 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 4.352471e-01 0.361 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 4.352471e-01 0.361 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 4.352471e-01 0.361 0 0
Synthesis of PC R-HSA-1483191 4.352471e-01 0.361 0 0
Co-stimulation by CD28 R-HSA-389356 4.410937e-01 0.355 0 0
Gluconeogenesis R-HSA-70263 4.410937e-01 0.355 0 0
NGF-stimulated transcription R-HSA-9031628 4.410937e-01 0.355 0 0
Mitotic Anaphase R-HSA-68882 4.435042e-01 0.353 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 4.462107e-01 0.350 0 0
DNA Damage Bypass R-HSA-73893 4.468803e-01 0.350 0 0
Degradation of CDH1 R-HSA-9766229 4.468803e-01 0.350 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 4.468803e-01 0.350 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 4.468803e-01 0.350 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 4.468803e-01 0.350 0 0
Gap junction trafficking and regulation R-HSA-157858 4.468803e-01 0.350 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 4.468803e-01 0.350 0 0
Cardiac conduction R-HSA-5576891 4.511385e-01 0.346 0 0
Regulation of RAS by GAPs R-HSA-5658442 4.526072e-01 0.344 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 4.526072e-01 0.344 0 0
PI3K Cascade R-HSA-109704 4.526072e-01 0.344 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 4.580353e-01 0.339 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 4.582752e-01 0.339 0 0
Hedgehog ligand biogenesis R-HSA-5358346 4.582752e-01 0.339 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 4.638849e-01 0.334 0 0
mRNA 3'-end processing R-HSA-72187 4.638849e-01 0.334 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 4.638849e-01 0.334 0 0
Orc1 removal from chromatin R-HSA-68949 4.638849e-01 0.334 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 4.638849e-01 0.334 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 4.638849e-01 0.334 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 4.694368e-01 0.328 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 4.694368e-01 0.328 0 0
Regulation of PTEN stability and activity R-HSA-8948751 4.694368e-01 0.328 0 0
Smooth Muscle Contraction R-HSA-445355 4.694368e-01 0.328 0 0
Organelle biogenesis and maintenance R-HSA-1852241 4.701835e-01 0.328 0 0
Integration of energy metabolism R-HSA-163685 4.716785e-01 0.326 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 4.749316e-01 0.323 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 4.803698e-01 0.318 0 0
G alpha (z) signalling events R-HSA-418597 4.803698e-01 0.318 0 0
Unfolded Protein Response (UPR) R-HSA-381119 4.817759e-01 0.317 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 4.857520e-01 0.314 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 4.857520e-01 0.314 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 4.857520e-01 0.314 0 0
IRS-mediated signalling R-HSA-112399 4.910788e-01 0.309 0 0
Nuclear Envelope Breakdown R-HSA-2980766 4.910788e-01 0.309 0 0
Synthesis of PA R-HSA-1483166 4.910788e-01 0.309 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 4.910788e-01 0.309 0 0
Late Phase of HIV Life Cycle R-HSA-162599 4.950544e-01 0.305 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 4.950544e-01 0.305 0 0
Dual incision in TC-NER R-HSA-6782135 4.963508e-01 0.304 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 4.963508e-01 0.304 0 0
Peroxisomal protein import R-HSA-9033241 5.015684e-01 0.300 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 5.015684e-01 0.300 0 0
Triglyceride metabolism R-HSA-8979227 5.015684e-01 0.300 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 5.067324e-01 0.295 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 5.067324e-01 0.295 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 5.067324e-01 0.295 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 5.067324e-01 0.295 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 5.067324e-01 0.295 0 0
Signaling by NOTCH R-HSA-157118 5.068811e-01 0.295 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 5.118431e-01 0.291 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 5.118431e-01 0.291 0 0
PLC beta mediated events R-HSA-112043 5.118431e-01 0.291 0 0
Cellular responses to stress R-HSA-2262752 5.161680e-01 0.287 0 0
Signaling by PDGF R-HSA-186797 5.169012e-01 0.287 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 5.169012e-01 0.287 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 5.169012e-01 0.287 0 0
tRNA processing in the nucleus R-HSA-6784531 5.169012e-01 0.287 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 5.169012e-01 0.287 0 0
Mitochondrial protein import R-HSA-1268020 5.169012e-01 0.287 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 5.219072e-01 0.282 0 0
Signaling by PTK6 R-HSA-8848021 5.219072e-01 0.282 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 5.219072e-01 0.282 0 0
CD22 mediated BCR regulation R-HSA-5690714 5.268617e-01 0.278 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 5.268617e-01 0.278 0 0
Protein localization R-HSA-9609507 5.304437e-01 0.275 0 0
PPARA activates gene expression R-HSA-1989781 5.366962e-01 0.270 0 0
G-protein mediated events R-HSA-112040 5.414208e-01 0.266 0 0
HIV Life Cycle R-HSA-162587 5.428916e-01 0.265 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 5.428916e-01 0.265 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 5.461742e-01 0.263 0 0
Regulated Necrosis R-HSA-5218859 5.461742e-01 0.263 0 0
Regulation of TP53 Activity R-HSA-5633007 5.520773e-01 0.258 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 5.555346e-01 0.255 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 5.555346e-01 0.255 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 5.555346e-01 0.255 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 5.555346e-01 0.255 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 5.601426e-01 0.252 0 0
Regulation of mitotic cell cycle R-HSA-453276 5.601426e-01 0.252 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 5.601426e-01 0.252 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 5.601426e-01 0.252 0 0
Hedgehog 'on' state R-HSA-5632684 5.601426e-01 0.252 0 0
ECM proteoglycans R-HSA-3000178 5.601426e-01 0.252 0 0
Signaling by Nuclear Receptors R-HSA-9006931 5.633429e-01 0.249 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 5.647030e-01 0.248 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 5.647030e-01 0.248 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 5.692165e-01 0.245 0 0
Switching of origins to a post-replicative state R-HSA-69052 5.692165e-01 0.245 0 0
Signaling by FGFR in disease R-HSA-1226099 5.736835e-01 0.241 0 0
Signaling by NOTCH4 R-HSA-9013694 5.736835e-01 0.241 0 0
Protein ubiquitination R-HSA-8852135 5.781044e-01 0.238 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 5.781044e-01 0.238 0 0
ISG15 antiviral mechanism R-HSA-1169408 5.781044e-01 0.238 0 0
Iron uptake and transport R-HSA-917937 5.781044e-01 0.238 0 0
UCH proteinases R-HSA-5689603 5.824797e-01 0.235 0 0
Signaling by NOTCH1 R-HSA-1980143 5.824797e-01 0.235 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 5.903744e-01 0.229 0 0
ABC transporter disorders R-HSA-5619084 5.910955e-01 0.228 0 0
PCP/CE pathway R-HSA-4086400 5.910955e-01 0.228 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 5.932182e-01 0.227 0 0
Leishmania parasite growth and survival R-HSA-9664433 5.932182e-01 0.227 0 0
Sensory processing of sound R-HSA-9659379 5.953369e-01 0.225 0 0
M Phase R-HSA-68886 6.035591e-01 0.219 0 0
Processing of DNA double-strand break ends R-HSA-5693607 6.036889e-01 0.219 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 6.036889e-01 0.219 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 6.078005e-01 0.216 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 6.078005e-01 0.216 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 6.118696e-01 0.213 0 0
Cellular Senescence R-HSA-2559583 6.127146e-01 0.213 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 6.158967e-01 0.210 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 6.158967e-01 0.210 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 6.198824e-01 0.208 0 0
Protein-protein interactions at synapses R-HSA-6794362 6.198824e-01 0.208 0 0
Post NMDA receptor activation events R-HSA-438064 6.315943e-01 0.200 0 0
Pyruvate metabolism R-HSA-70268 6.315943e-01 0.200 0 0
Vesicle-mediated transport R-HSA-5653656 6.322805e-01 0.199 0 0
Cell Cycle R-HSA-1640170 6.349315e-01 0.197 0 0
Diseases of programmed cell death R-HSA-9645723 6.354180e-01 0.197 0 0
Phospholipid metabolism R-HSA-1483257 6.364054e-01 0.196 0 0
Ion channel transport R-HSA-983712 6.367292e-01 0.196 0 0
ER-Phagosome pathway R-HSA-1236974 6.392022e-01 0.194 0 0
Downstream TCR signaling R-HSA-202424 6.429474e-01 0.192 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 6.466539e-01 0.189 0 0
Mitotic Prometaphase R-HSA-68877 6.470246e-01 0.189 0 0
EPH-Ephrin signaling R-HSA-2682334 6.539527e-01 0.184 0 0
FCGR activation R-HSA-2029481 6.575457e-01 0.182 0 0
Assembly of the pre-replicative complex R-HSA-68867 6.575457e-01 0.182 0 0
Mitochondrial protein degradation R-HSA-9837999 6.611015e-01 0.180 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 6.644874e-01 0.178 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 6.646207e-01 0.177 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 6.681036e-01 0.175 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 6.715505e-01 0.173 0 0
COPI-mediated anterograde transport R-HSA-6807878 6.715505e-01 0.173 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 6.717574e-01 0.173 0 0
Keratinization R-HSA-6805567 6.812530e-01 0.167 0 0
HATs acetylate histones R-HSA-3214847 6.816791e-01 0.166 0 0
ABC-family proteins mediated transport R-HSA-382556 6.849859e-01 0.164 0 0
Hedgehog 'off' state R-HSA-5610787 6.849859e-01 0.164 0 0
Glycolysis R-HSA-70171 6.849859e-01 0.164 0 0
Translation R-HSA-72766 6.888280e-01 0.162 0 0
PI Metabolism R-HSA-1483255 6.914973e-01 0.160 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 6.914973e-01 0.160 0 0
Opioid Signalling R-HSA-111885 6.978748e-01 0.156 0 0
RSV-host interactions R-HSA-9833110 7.010143e-01 0.154 0 0
Nucleotide Excision Repair R-HSA-5696398 7.041214e-01 0.152 0 0
Platelet homeostasis R-HSA-418346 7.071963e-01 0.150 0 0
Drug ADME R-HSA-9748784 7.084057e-01 0.150 0 0
Synthesis of DNA R-HSA-69239 7.102395e-01 0.149 0 0
Antigen processing-Cross presentation R-HSA-1236975 7.132512e-01 0.147 0 0
Neddylation R-HSA-8951664 7.148870e-01 0.146 0 0
DNA Replication Pre-Initiation R-HSA-69002 7.162318e-01 0.145 0 0
Inositol phosphate metabolism R-HSA-1483249 7.249902e-01 0.140 0 0
HIV Infection R-HSA-162906 7.274893e-01 0.138 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 7.278495e-01 0.138 0 0
Chromatin modifying enzymes R-HSA-3247509 7.415968e-01 0.130 0 0
L1CAM interactions R-HSA-373760 7.417088e-01 0.130 0 0
Glucose metabolism R-HSA-70326 7.443952e-01 0.128 0 0
Cell surface interactions at the vascular wall R-HSA-202733 7.474505e-01 0.126 0 0
Developmental Biology R-HSA-1266738 7.490300e-01 0.126 0 0
Neuronal System R-HSA-112316 7.491890e-01 0.125 0 0
Mitotic Prophase R-HSA-68875 7.522892e-01 0.124 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 7.548663e-01 0.122 0 0
DNA Repair R-HSA-73894 7.565962e-01 0.121 0 0
Host Interactions of HIV factors R-HSA-162909 7.624387e-01 0.118 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 7.673573e-01 0.115 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 7.673573e-01 0.115 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 7.673573e-01 0.115 0 0
Chromatin organization R-HSA-4839726 7.697454e-01 0.114 0 0
Platelet degranulation R-HSA-114608 7.721747e-01 0.112 0 0
Adipogenesis R-HSA-9843745 7.837888e-01 0.106 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 7.860400e-01 0.105 0 0
Circadian clock R-HSA-9909396 7.860400e-01 0.105 0 0
Estrogen-dependent gene expression R-HSA-9018519 7.969512e-01 0.099 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 7.969512e-01 0.099 0 0
O-linked glycosylation R-HSA-5173105 7.990662e-01 0.097 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 7.990662e-01 0.097 0 0
Signaling by Hedgehog R-HSA-5358351 8.011592e-01 0.096 0 0
Bacterial Infection Pathways R-HSA-9824439 8.016081e-01 0.096 0 0
PTEN Regulation R-HSA-6807070 8.032306e-01 0.095 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 8.132700e-01 0.090 0 0
FCERI mediated NF-kB activation R-HSA-2871837 8.152160e-01 0.089 0 0
ER to Golgi Anterograde Transport R-HSA-199977 8.209337e-01 0.086 0 0
Fatty acid metabolism R-HSA-8978868 8.232110e-01 0.084 0 0
Gastrulation R-HSA-9758941 8.246474e-01 0.084 0 0
Arachidonate metabolism R-HSA-2142753 8.300749e-01 0.081 0 0
DNA Replication R-HSA-69306 8.318467e-01 0.080 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 8.336002e-01 0.079 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 8.336002e-01 0.079 0 0
GPCR downstream signalling R-HSA-388396 8.369702e-01 0.077 0 0
Signaling by WNT R-HSA-195721 8.439264e-01 0.074 0 0
Diseases of metabolism R-HSA-5668914 8.460449e-01 0.073 0 0
tRNA processing R-HSA-72306 8.607749e-01 0.065 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 8.678927e-01 0.062 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 8.737183e-01 0.059 0 0
TCF dependent signaling in response to WNT R-HSA-201681 8.785363e-01 0.056 0 0
Diseases of glycosylation R-HSA-3781865 8.798053e-01 0.056 0 0
Cilium Assembly R-HSA-5617833 8.871474e-01 0.052 0 0
Signaling by GPCR R-HSA-372790 8.971317e-01 0.047 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.005207e-01 0.046 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.012462e-01 0.045 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 9.113901e-01 0.040 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.259109e-01 0.033 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.387138e-01 0.027 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.457370e-01 0.024 0 0
G alpha (q) signalling events R-HSA-416476 9.487772e-01 0.023 0 0
Transmission across Chemical Synapses R-HSA-112315 9.725556e-01 0.012 0 0
Epigenetic regulation of gene expression R-HSA-212165 9.725556e-01 0.012 0 0
G alpha (i) signalling events R-HSA-418594 9.888769e-01 0.005 0 0
Metabolism of lipids R-HSA-556833 9.904874e-01 0.004 0 0
Post-translational protein modification R-HSA-597592 9.927469e-01 0.003 0 0
Transport of small molecules R-HSA-382551 9.935204e-01 0.003 0 0
Metabolism of proteins R-HSA-392499 9.966103e-01 0.001 0 0
Metabolism R-HSA-1430728 9.998513e-01 0.000 0 0
Sensory Perception R-HSA-9709957 9.999987e-01 0.000 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.000000e+00 0.000 1 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.000000e+00 0.000 1 1
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
HSF1 activation R-HSA-3371511 1.110223e-16 15.955 0 0
Attenuation phase R-HSA-3371568 1.110223e-16 15.955 0 0
Cellular response to heat stress R-HSA-3371556 1.110223e-16 15.955 0 0
HSF1-dependent transactivation R-HSA-3371571 1.110223e-16 15.955 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.110223e-16 15.955 0 0
Cellular responses to stress R-HSA-2262752 1.110223e-16 15.955 0 0
Cellular responses to stimuli R-HSA-8953897 4.440892e-16 15.353 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 5.562217e-14 13.255 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 2.670919e-11 10.573 0 0
Axon guidance R-HSA-422475 3.580924e-11 10.446 0 0
Nervous system development R-HSA-9675108 2.340211e-10 9.631 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 6.512482e-10 9.186 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.042104e-09 8.982 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 2.052984e-09 8.688 0 0
Post NMDA receptor activation events R-HSA-438064 6.027758e-09 8.220 0 0
Interleukin-12 signaling R-HSA-9020591 8.760434e-09 8.057 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.445081e-08 7.840 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.445081e-08 7.840 0 0
PKR-mediated signaling R-HSA-9833482 1.553659e-08 7.809 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 2.417347e-08 7.617 0 0
Interleukin-12 family signaling R-HSA-447115 4.491402e-08 7.348 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 4.982202e-08 7.303 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 8.044737e-08 7.094 0 0
SARS-CoV-1-host interactions R-HSA-9692914 8.647559e-08 7.063 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.173947e-07 6.930 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.356058e-07 6.868 0 0
Apoptosis R-HSA-109581 1.557813e-07 6.807 0 0
Programmed Cell Death R-HSA-5357801 2.044598e-07 6.689 0 0
EPHB-mediated forward signaling R-HSA-3928662 3.289015e-07 6.483 0 0
Recycling pathway of L1 R-HSA-437239 5.439884e-07 6.264 0 0
EPH-Ephrin signaling R-HSA-2682334 6.102185e-07 6.215 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 6.110811e-07 6.214 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 7.507082e-07 6.125 0 0
Gap junction trafficking and regulation R-HSA-157858 7.481760e-07 6.126 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 8.591224e-07 6.066 0 0
Cytokine Signaling in Immune system R-HSA-1280215 8.368813e-07 6.077 0 0
Membrane Trafficking R-HSA-199991 9.317855e-07 6.031 0 0
SARS-CoV-2-host interactions R-HSA-9705683 9.102211e-07 6.041 0 0
G2/M Transition R-HSA-69275 9.897836e-07 6.004 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.005748e-06 5.998 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.133317e-06 5.946 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.143587e-06 5.942 0 0
Aggrephagy R-HSA-9646399 1.321897e-06 5.879 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.299144e-06 5.886 0 0
Viral Infection Pathways R-HSA-9824446 1.418008e-06 5.848 0 0
L1CAM interactions R-HSA-373760 1.610912e-06 5.793 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 1.736778e-06 5.760 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.739523e-06 5.760 0 0
Activation of BH3-only proteins R-HSA-114452 1.739523e-06 5.760 0 0
Chaperonin-mediated protein folding R-HSA-390466 2.009014e-06 5.697 0 0
SARS-CoV-1 Infection R-HSA-9678108 2.031740e-06 5.692 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.231318e-06 5.651 0 0
Selective autophagy R-HSA-9663891 2.231318e-06 5.651 0 0
Developmental Biology R-HSA-1266738 2.490058e-06 5.604 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 2.726260e-06 5.564 0 0
Gap junction trafficking R-HSA-190828 2.984801e-06 5.525 0 0
Protein folding R-HSA-391251 3.701492e-06 5.432 0 0
Signaling by ERBB2 R-HSA-1227986 3.536184e-06 5.451 0 0
Signaling by PTK6 R-HSA-8848021 5.140613e-06 5.289 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 5.140613e-06 5.289 0 0
Signal Transduction R-HSA-162582 6.912530e-06 5.160 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 7.447177e-06 5.128 0 0
Autophagy R-HSA-9612973 9.788017e-06 5.009 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.044556e-05 4.981 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.859722e-06 5.006 0 0
Signaling by Hedgehog R-HSA-5358351 1.160398e-05 4.935 0 0
Translation initiation complex formation R-HSA-72649 1.201313e-05 4.920 0 0
Ephrin signaling R-HSA-3928664 1.431922e-05 4.844 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.426769e-05 4.846 0 0
Cell Cycle R-HSA-1640170 1.534489e-05 4.814 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.538926e-05 4.813 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.603145e-05 4.795 0 0
MAP2K and MAPK activation R-HSA-5674135 1.603145e-05 4.795 0 0
Regulation of CDH1 Function R-HSA-9764561 1.736016e-05 4.760 0 0
Vesicle-mediated transport R-HSA-5653656 1.801515e-05 4.744 0 0
Nuclear Receptor transcription pathway R-HSA-383280 2.621256e-05 4.581 0 0
MAPK family signaling cascades R-HSA-5683057 2.753163e-05 4.560 0 0
Signaling downstream of RAS mutants R-HSA-9649948 3.174202e-05 4.498 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 3.174202e-05 4.498 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 3.174202e-05 4.498 0 0
Signaling by RAS mutants R-HSA-6802949 3.174202e-05 4.498 0 0
Apoptotic execution phase R-HSA-75153 3.174202e-05 4.498 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 3.007873e-05 4.522 0 0
Infectious disease R-HSA-5663205 3.158104e-05 4.501 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 3.607512e-05 4.443 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 3.673976e-05 4.435 0 0
Cap-dependent Translation Initiation R-HSA-72737 3.953491e-05 4.403 0 0
Eukaryotic Translation Initiation R-HSA-72613 3.953491e-05 4.403 0 0
Gap junction assembly R-HSA-190861 4.112797e-05 4.386 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 4.238191e-05 4.373 0 0
Glycolysis R-HSA-70171 4.415736e-05 4.355 0 0
Hedgehog 'off' state R-HSA-5610787 4.415736e-05 4.355 0 0
Signaling by Interleukins R-HSA-449147 4.833879e-05 4.316 0 0
Oncogenic MAPK signaling R-HSA-6802957 5.013743e-05 4.300 0 0
Macroautophagy R-HSA-1632852 6.070740e-05 4.217 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 7.113308e-05 4.148 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 7.221652e-05 4.141 0 0
Smooth Muscle Contraction R-HSA-445355 7.377606e-05 4.132 0 0
Translation R-HSA-72766 7.389910e-05 4.131 0 0
Signaling by VEGF R-HSA-194138 7.929680e-05 4.101 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 8.208845e-05 4.086 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 7.699108e-05 4.114 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 8.755137e-05 4.058 0 0
G2/M Checkpoints R-HSA-69481 9.044875e-05 4.044 0 0
SARS-CoV Infections R-HSA-9679506 9.108331e-05 4.041 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.197579e-05 4.036 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 9.294976e-05 4.032 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.017194e-04 3.993 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.023831e-04 3.990 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.145264e-04 3.941 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.234498e-04 3.909 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.660241e-04 3.780 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.714086e-04 3.766 0 0
Glucose metabolism R-HSA-70326 1.859909e-04 3.731 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.921541e-04 3.716 0 0
FOXO-mediated transcription R-HSA-9614085 1.941817e-04 3.712 0 0
RAF/MAP kinase cascade R-HSA-5673001 2.071485e-04 3.684 0 0
Folding of actin by CCT/TriC R-HSA-390450 2.158603e-04 3.666 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 2.479473e-04 3.606 0 0
Cilium Assembly R-HSA-5617833 2.664811e-04 3.574 0 0
Cell Cycle, Mitotic R-HSA-69278 2.901519e-04 3.537 0 0
Mitotic Prometaphase R-HSA-68877 3.069233e-04 3.513 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 3.307547e-04 3.480 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 3.307547e-04 3.480 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 3.830997e-04 3.417 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 3.830997e-04 3.417 0 0
Signaling by ROBO receptors R-HSA-376176 4.819694e-04 3.317 0 0
Eukaryotic Translation Elongation R-HSA-156842 4.966864e-04 3.304 0 0
Signaling by NOTCH4 R-HSA-9013694 5.305781e-04 3.275 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 5.827299e-04 3.235 0 0
Signaling by EGFR R-HSA-177929 6.064631e-04 3.217 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 6.273059e-04 3.203 0 0
Organelle biogenesis and maintenance R-HSA-1852241 6.310303e-04 3.200 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 7.281891e-04 3.138 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 6.730235e-04 3.172 0 0
Long-term potentiation R-HSA-9620244 6.744749e-04 3.171 0 0
Metabolism of RNA R-HSA-8953854 6.945997e-04 3.158 0 0
M Phase R-HSA-68886 7.115861e-04 3.148 0 0
Muscle contraction R-HSA-397014 7.357702e-04 3.133 0 0
Interferon Signaling R-HSA-913531 7.332200e-04 3.135 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 7.499088e-04 3.125 0 0
Kinesins R-HSA-983189 8.610957e-04 3.065 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 8.886603e-04 3.051 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 9.239037e-04 3.034 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.102259e-03 2.958 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.102259e-03 2.958 0 0
Semaphorin interactions R-HSA-373755 1.102259e-03 2.958 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.105145e-03 2.957 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.152721e-03 2.938 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 1.281591e-03 2.892 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.289710e-03 2.890 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.289710e-03 2.890 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.303807e-03 2.885 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.393501e-03 2.856 0 0
Intraflagellar transport R-HSA-5620924 1.635877e-03 2.786 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.615201e-03 2.792 0 0
Co-stimulation by CD28 R-HSA-389356 1.635877e-03 2.786 0 0
Gluconeogenesis R-HSA-70263 1.635877e-03 2.786 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.405511e-03 2.852 0 0
Transmission across Chemical Synapses R-HSA-112315 1.773230e-03 2.751 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.782200e-03 2.749 0 0
ESR-mediated signaling R-HSA-8939211 1.900821e-03 2.721 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.938681e-03 2.712 0 0
Immune System R-HSA-168256 1.949439e-03 2.710 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 2.008843e-03 2.697 0 0
Striated Muscle Contraction R-HSA-390522 2.057365e-03 2.687 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 2.153817e-03 2.667 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.306744e-03 2.637 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.324414e-03 2.634 0 0
Co-inhibition by CTLA4 R-HSA-389513 2.404365e-03 2.619 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 2.434380e-03 2.614 0 0
Signaling by ERBB4 R-HSA-1236394 2.467909e-03 2.608 0 0
Mitotic Anaphase R-HSA-68882 2.478179e-03 2.606 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 2.568355e-03 2.590 0 0
Separation of Sister Chromatids R-HSA-2467813 2.611287e-03 2.583 0 0
Centrosome maturation R-HSA-380287 2.637605e-03 2.579 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 2.637605e-03 2.579 0 0
Clathrin-mediated endocytosis R-HSA-8856828 3.326302e-03 2.478 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 3.098702e-03 2.509 0 0
COPI-mediated anterograde transport R-HSA-6807878 2.798481e-03 2.553 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 3.227015e-03 2.491 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 3.326643e-03 2.478 0 0
Cell-Cell communication R-HSA-1500931 3.514481e-03 2.454 1 0
mTORC1-mediated signalling R-HSA-166208 3.595070e-03 2.444 0 0
Cell Cycle Checkpoints R-HSA-69620 3.806603e-03 2.419 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 4.579435e-03 2.339 0 0
Neutrophil degranulation R-HSA-6798695 4.976600e-03 2.303 0 0
MTOR signalling R-HSA-165159 5.265490e-03 2.279 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 5.505539e-03 2.259 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 6.005519e-03 2.221 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 6.185485e-03 2.209 0 0
Neuronal System R-HSA-112316 6.327813e-03 2.199 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 6.498787e-03 2.187 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 6.760716e-03 2.170 0 0
Cell junction organization R-HSA-446728 6.851386e-03 2.164 1 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 7.043703e-03 2.152 0 0
Adherens junctions interactions R-HSA-418990 7.044039e-03 2.152 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 7.212937e-03 2.142 0 0
Regulation of KIT signaling R-HSA-1433559 7.592006e-03 2.120 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 7.795224e-03 2.108 0 0
Ribosome-associated quality control R-HSA-9948299 7.935996e-03 2.100 0 0
mRNA Splicing - Major Pathway R-HSA-72163 8.178798e-03 2.087 0 0
Interleukin-37 signaling R-HSA-9008059 8.578864e-03 2.067 0 0
HCMV Early Events R-HSA-9609690 8.727753e-03 2.059 0 0
Protein methylation R-HSA-8876725 8.787416e-03 2.056 0 0
Cell-extracellular matrix interactions R-HSA-446353 8.787416e-03 2.056 1 0
SHC1 events in ERBB4 signaling R-HSA-1250347 1.149224e-02 1.940 0 0
EGFR downregulation R-HSA-182971 9.412302e-03 2.026 0 0
mRNA Splicing R-HSA-72172 1.155943e-02 1.937 0 0
Integrin signaling R-HSA-354192 1.123320e-02 1.949 0 0
G-protein beta:gamma signalling R-HSA-397795 1.123320e-02 1.949 0 0
Developmental Cell Lineages R-HSA-9734767 1.067440e-02 1.972 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.006837e-02 1.997 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.029671e-02 1.987 0 0
ER to Golgi Anterograde Transport R-HSA-199977 1.156387e-02 1.937 0 0
MHC class II antigen presentation R-HSA-2132295 1.160672e-02 1.935 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.222283e-02 1.913 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.300469e-02 1.886 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.300469e-02 1.886 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 1.300469e-02 1.886 0 0
Signaling by Hippo R-HSA-2028269 1.300469e-02 1.886 0 0
Influenza Infection R-HSA-168255 1.312250e-02 1.882 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.366239e-02 1.864 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.442386e-02 1.841 0 0
GAB1 signalosome R-HSA-180292 1.462543e-02 1.835 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.510119e-02 1.821 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 1.526269e-02 1.816 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 1.552038e-02 1.809 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 1.577751e-02 1.802 0 0
Rap1 signalling R-HSA-392517 1.635536e-02 1.786 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 1.704368e-02 1.768 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.704579e-02 1.768 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.759095e-02 1.755 0 0
Cell-cell junction organization R-HSA-421270 1.787937e-02 1.748 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 1.932906e-02 1.714 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.997962e-02 1.699 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 2.014527e-02 1.696 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 2.014527e-02 1.696 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 2.014527e-02 1.696 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.025540e-02 1.693 0 0
Pyruvate metabolism R-HSA-70268 2.027328e-02 1.693 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 2.071571e-02 1.684 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 2.074574e-02 1.683 0 0
Disease R-HSA-1643685 2.080660e-02 1.682 0 0
Peptide chain elongation R-HSA-156902 2.119438e-02 1.674 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.216198e-02 1.654 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 2.220598e-02 1.654 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.286414e-02 1.641 0 0
RNA Polymerase II Transcription R-HSA-73857 2.323470e-02 1.634 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.336244e-02 1.631 0 0
FGFR2 alternative splicing R-HSA-6803529 2.437734e-02 1.613 0 0
Formation of annular gap junctions R-HSA-196025 2.474700e-02 1.606 0 0
Interleukin-23 signaling R-HSA-9020933 2.474700e-02 1.606 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 2.474700e-02 1.606 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 2.474700e-02 1.606 0 0
Gap junction degradation R-HSA-190873 2.903484e-02 1.537 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 2.903484e-02 1.537 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.665926e-02 1.574 0 0
Deadenylation of mRNA R-HSA-429947 2.905145e-02 1.537 0 0
Formation of a pool of free 40S subunits R-HSA-72689 3.077852e-02 1.512 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.785245e-02 1.555 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 3.030512e-02 1.518 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.903484e-02 1.537 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 3.302583e-02 1.481 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 2.903484e-02 1.537 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 2.822097e-02 1.549 0 0
Platelet activation, signaling and aggregation R-HSA-76002 3.077736e-02 1.512 0 0
Signaling by NOTCH R-HSA-157118 3.026143e-02 1.519 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.903484e-02 1.537 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 2.903484e-02 1.537 0 0
Generic Transcription Pathway R-HSA-212436 2.773800e-02 1.557 0 0
Hemostasis R-HSA-109582 3.303592e-02 1.481 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 3.359504e-02 1.474 0 0
Signaling by EGFR in Cancer R-HSA-1643713 3.416479e-02 1.466 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 3.427788e-02 1.465 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 3.567030e-02 1.448 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 3.688463e-02 1.433 0 0
Interaction between L1 and Ankyrins R-HSA-445095 3.688463e-02 1.433 0 0
HCMV Infection R-HSA-9609646 3.801496e-02 1.420 0 0
PECAM1 interactions R-HSA-210990 3.841382e-02 1.416 0 0
Hedgehog ligand biogenesis R-HSA-5358346 4.212597e-02 1.375 0 0
PCP/CE pathway R-HSA-4086400 4.244016e-02 1.372 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 4.289817e-02 1.368 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 4.289817e-02 1.368 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 4.347791e-02 1.362 0 0
Activation of RAC1 R-HSA-428540 4.347791e-02 1.362 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 4.522405e-02 1.345 0 0
Signaling by Nuclear Receptors R-HSA-9006931 4.535511e-02 1.343 0 0
Signaling by FGFR2 R-HSA-5654738 4.600576e-02 1.337 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 4.706103e-02 1.327 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 4.877447e-02 1.312 0 0
Scavenging by Class F Receptors R-HSA-3000484 4.877447e-02 1.312 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 4.877447e-02 1.312 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 4.883056e-02 1.311 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 4.888319e-02 1.311 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 4.974463e-02 1.303 0 0
Signaling by WNT R-HSA-195721 5.027342e-02 1.299 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 5.429108e-02 1.265 0 0
Interleukin-6 signaling R-HSA-1059683 5.429108e-02 1.265 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 5.429108e-02 1.265 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 5.429108e-02 1.265 0 0
CD28 dependent Vav1 pathway R-HSA-389359 5.429108e-02 1.265 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 5.460387e-02 1.263 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 5.567877e-02 1.254 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 6.365405e-02 1.196 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 6.365405e-02 1.196 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 8.396107e-02 1.076 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 8.396107e-02 1.076 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 8.396107e-02 1.076 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 8.396107e-02 1.076 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 8.396107e-02 1.076 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 8.396107e-02 1.076 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 8.396107e-02 1.076 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 8.396107e-02 1.076 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 8.396107e-02 1.076 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 8.396107e-02 1.076 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 8.396107e-02 1.076 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 8.396107e-02 1.076 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 7.204363e-02 1.142 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 7.832484e-02 1.106 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 7.104327e-02 1.148 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 7.341049e-02 1.134 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 8.330392e-02 1.079 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 5.749016e-02 1.240 0 0
Regulation of Apoptosis R-HSA-169911 6.606984e-02 1.180 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 5.749016e-02 1.240 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 6.242465e-02 1.205 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 7.832484e-02 1.106 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 6.242465e-02 1.205 0 0
DCC mediated attractive signaling R-HSA-418885 6.593703e-02 1.181 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 5.887653e-02 1.230 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 6.593703e-02 1.181 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 6.157789e-02 1.211 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 7.757059e-02 1.110 0 0
eNOS activation R-HSA-203615 6.242465e-02 1.205 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 8.115449e-02 1.091 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 6.365405e-02 1.196 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 6.365405e-02 1.196 0 0
Manipulation of host energy metabolism R-HSA-9636667 6.365405e-02 1.196 0 0
mRNA Editing: A to I Conversion R-HSA-75064 8.396107e-02 1.076 0 0
C6 deamination of adenosine R-HSA-75102 8.396107e-02 1.076 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 8.396107e-02 1.076 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 6.593703e-02 1.181 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 7.832484e-02 1.106 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 7.204363e-02 1.142 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 8.338117e-02 1.079 0 0
Spry regulation of FGF signaling R-HSA-1295596 6.593703e-02 1.181 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 7.364459e-02 1.133 0 0
Diseases of cellular response to stress R-HSA-9675132 8.396107e-02 1.076 0 0
Diseases of Cellular Senescence R-HSA-9630747 8.396107e-02 1.076 0 0
Nuclear Envelope Breakdown R-HSA-2980766 5.620247e-02 1.250 0 0
Rab regulation of trafficking R-HSA-9007101 7.073851e-02 1.150 0 0
Gene expression (Transcription) R-HSA-74160 5.826575e-02 1.235 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 7.832484e-02 1.106 0 0
TCF dependent signaling in response to WNT R-HSA-201681 7.950059e-02 1.100 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 6.489738e-02 1.188 0 0
RET signaling R-HSA-8853659 6.981040e-02 1.156 0 0
Innate Immune System R-HSA-168249 6.830674e-02 1.166 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 6.044865e-02 1.219 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 7.832484e-02 1.106 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 7.482131e-02 1.126 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 5.713265e-02 1.243 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 8.477025e-02 1.072 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 8.569048e-02 1.067 0 0
Generation of second messenger molecules R-HSA-202433 8.569048e-02 1.067 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 8.569048e-02 1.067 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 8.588234e-02 1.066 0 0
Eukaryotic Translation Termination R-HSA-72764 8.588234e-02 1.066 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 8.988051e-02 1.046 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 8.988051e-02 1.046 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 9.092803e-02 1.041 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 9.136984e-02 1.039 0 0
PKA activation R-HSA-163615 9.136984e-02 1.039 0 0
Synaptic adhesion-like molecules R-HSA-8849932 9.136984e-02 1.039 0 0
PKA activation in glucagon signalling R-HSA-164378 9.136984e-02 1.039 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 9.136984e-02 1.039 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 9.136984e-02 1.039 0 0
Signaling by FGFR R-HSA-190236 9.386574e-02 1.027 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.415463e-02 1.026 0 0
HIV Transcription Initiation R-HSA-167161 9.415463e-02 1.026 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.415463e-02 1.026 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 9.415463e-02 1.026 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.415463e-02 1.026 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.415463e-02 1.026 0 0
Negative regulation of MAPK pathway R-HSA-5675221 9.415463e-02 1.026 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 9.419834e-02 1.026 0 0
Platelet degranulation R-HSA-114608 9.481229e-02 1.023 0 0
HIV Infection R-HSA-162906 9.690331e-02 1.014 0 0
Hedgehog 'on' state R-HSA-5632684 9.752367e-02 1.011 0 0
Regulation of signaling by CBL R-HSA-912631 9.811394e-02 1.008 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 9.811394e-02 1.008 0 0
The NLRP3 inflammasome R-HSA-844456 9.811394e-02 1.008 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.851080e-02 1.007 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 9.851080e-02 1.007 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.009033e-01 0.996 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.009033e-01 0.996 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 1.022151e-01 0.990 0 0
Selenocysteine synthesis R-HSA-2408557 1.022151e-01 0.990 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 1.029470e-01 0.987 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 1.029470e-01 0.987 0 0
Signaling by SCF-KIT R-HSA-1433557 1.029470e-01 0.987 0 0
Response of Mtb to phagocytosis R-HSA-9637690 1.029470e-01 0.987 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 1.038289e-01 0.984 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.043365e-01 0.982 0 0
Negative regulation of MET activity R-HSA-6807004 1.049932e-01 0.979 0 0
Protein hydroxylation R-HSA-9629569 1.049932e-01 0.979 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 1.049932e-01 0.979 0 0
Signal transduction by L1 R-HSA-445144 1.049932e-01 0.979 0 0
Cellular response to chemical stress R-HSA-9711123 1.052485e-01 0.978 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.232670e-01 0.909 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.232670e-01 0.909 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 1.232670e-01 0.909 0 0
IRS activation R-HSA-74713 1.422847e-01 0.847 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 1.422847e-01 0.847 0 0
G2 Phase R-HSA-68911 1.422847e-01 0.847 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 1.422847e-01 0.847 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 1.608910e-01 0.793 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 1.608910e-01 0.793 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 1.608910e-01 0.793 0 0
Signaling by MAPK mutants R-HSA-9652817 1.608910e-01 0.793 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 1.790947e-01 0.747 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 1.790947e-01 0.747 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 1.969047e-01 0.706 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.969047e-01 0.706 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 1.120510e-01 0.951 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.872354e-01 0.728 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.951216e-01 0.710 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.951216e-01 0.710 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.110114e-01 0.676 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.110114e-01 0.676 0 0
mRNA 3'-end processing R-HSA-72187 1.461240e-01 0.835 0 0
Viral mRNA Translation R-HSA-192823 1.079802e-01 0.967 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 1.074611e-01 0.969 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 1.969047e-01 0.706 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 1.461240e-01 0.835 0 0
Regulation of gap junction activity R-HSA-191650 1.232670e-01 0.909 0 0
Signaling by MST1 R-HSA-8852405 1.608910e-01 0.793 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.830705e-01 0.737 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 1.119987e-01 0.951 0 0
Interleukin-6 family signaling R-HSA-6783589 1.411138e-01 0.850 0 0
PTK6 Expression R-HSA-8849473 1.969047e-01 0.706 0 0
G1 Phase R-HSA-69236 1.074611e-01 0.969 0 0
Cyclin D associated events in G1 R-HSA-69231 1.074611e-01 0.969 0 0
Mitochondrial protein import R-HSA-1268020 1.996029e-01 0.700 0 0
Late Phase of HIV Life Cycle R-HSA-162599 1.423779e-01 0.847 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 1.263538e-01 0.898 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 1.772309e-01 0.751 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 1.608910e-01 0.793 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 1.608910e-01 0.793 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 1.951216e-01 0.710 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.248903e-01 0.903 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 1.638806e-01 0.785 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 1.232670e-01 0.909 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 1.232670e-01 0.909 0 0
Reelin signalling pathway R-HSA-8866376 1.422847e-01 0.847 0 0
Suppression of autophagy R-HSA-9636569 1.422847e-01 0.847 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 1.608910e-01 0.793 0 0
Cristae formation R-HSA-8949613 1.638806e-01 0.785 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 1.120510e-01 0.951 0 0
Orc1 removal from chromatin R-HSA-68949 1.461240e-01 0.835 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 1.564192e-01 0.806 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.940518e-01 0.712 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 1.960907e-01 0.708 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 1.716089e-01 0.765 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 1.793958e-01 0.746 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 1.120510e-01 0.951 0 0
Cellular response to starvation R-HSA-9711097 1.921655e-01 0.716 0 0
HIV Life Cycle R-HSA-162587 1.888738e-01 0.724 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.167146e-01 0.933 0 0
GPER1 signaling R-HSA-9634597 1.262544e-01 0.899 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 2.110114e-01 0.676 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 1.830705e-01 0.737 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 1.872354e-01 0.728 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.109213e-01 0.955 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.457222e-01 0.836 0 0
Mitotic Prophase R-HSA-68875 1.736084e-01 0.760 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.542171e-01 0.812 0 0
NADE modulates death signalling R-HSA-205025 1.232670e-01 0.909 0 0
VLDL clearance R-HSA-8964046 1.969047e-01 0.706 0 0
LDL remodeling R-HSA-8964041 1.969047e-01 0.706 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 1.263538e-01 0.898 0 0
DARPP-32 events R-HSA-180024 1.793958e-01 0.746 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.872354e-01 0.728 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 2.030487e-01 0.692 0 0
Metabolism of non-coding RNA R-HSA-194441 1.830705e-01 0.737 0 0
snRNP Assembly R-HSA-191859 1.830705e-01 0.737 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 1.534637e-01 0.814 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 1.790947e-01 0.747 0 0
Signaling by KIT in disease R-HSA-9669938 1.263538e-01 0.898 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 1.263538e-01 0.898 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 1.120510e-01 0.951 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.725811e-01 0.763 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.298006e-01 0.887 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 1.608910e-01 0.793 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 1.969047e-01 0.706 0 0
Netrin mediated repulsion signals R-HSA-418886 1.969047e-01 0.706 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.336871e-01 0.874 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 1.336871e-01 0.874 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 1.951216e-01 0.710 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 1.109213e-01 0.955 0 0
PLC beta mediated events R-HSA-112043 1.940518e-01 0.712 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.940518e-01 0.712 0 0
Aquaporin-mediated transport R-HSA-445717 1.940518e-01 0.712 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 1.562176e-01 0.806 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 1.534637e-01 0.814 0 0
HDMs demethylate histones R-HSA-3214842 1.486263e-01 0.828 0 0
TCR signaling R-HSA-202403 1.325647e-01 0.878 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 1.227315e-01 0.911 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 1.996029e-01 0.700 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 1.121490e-01 0.950 0 0
Plasma lipoprotein assembly R-HSA-8963898 1.411138e-01 0.850 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.422847e-01 0.847 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.608910e-01 0.793 1 1
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 1.608910e-01 0.793 0 0
Nef and signal transduction R-HSA-164944 1.790947e-01 0.747 0 0
VLDL assembly R-HSA-8866423 1.790947e-01 0.747 0 0
CHL1 interactions R-HSA-447041 1.969047e-01 0.706 0 0
Degradation of CDH1 R-HSA-9766229 1.311263e-01 0.882 0 0
Diseases of mitotic cell cycle R-HSA-9675126 2.030487e-01 0.692 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.110114e-01 0.676 0 0
Signaling by NOTCH3 R-HSA-9012852 1.616494e-01 0.791 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 1.940518e-01 0.712 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.722641e-01 0.764 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 1.562176e-01 0.806 0 0
Cellular Senescence R-HSA-2559583 1.504823e-01 0.823 0 0
Regulation of PTEN stability and activity R-HSA-8948751 1.512434e-01 0.820 0 0
Host Interactions of HIV factors R-HSA-162909 1.882671e-01 0.725 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.191217e-01 0.924 0 0
Inflammasomes R-HSA-622312 1.716089e-01 0.765 0 0
Regulation of necroptotic cell death R-HSA-5675482 2.110114e-01 0.676 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 1.311263e-01 0.882 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 1.311263e-01 0.882 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 1.486263e-01 0.828 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 1.969047e-01 0.706 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 1.872354e-01 0.728 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.113603e-01 0.953 0 0
Gene Silencing by RNA R-HSA-211000 1.230671e-01 0.910 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 2.051915e-01 0.688 0 0
Selenoamino acid metabolism R-HSA-2408522 1.084161e-01 0.965 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 1.872354e-01 0.728 0 0
Potential therapeutics for SARS R-HSA-9679191 1.664764e-01 0.779 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 1.263538e-01 0.898 0 0
Formation of paraxial mesoderm R-HSA-9793380 1.940518e-01 0.712 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.191217e-01 0.924 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.191217e-01 0.924 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 1.669317e-01 0.777 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 1.716089e-01 0.765 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 2.110114e-01 0.676 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 1.461240e-01 0.835 0 0
XBP1(S) activates chaperone genes R-HSA-381038 1.575573e-01 0.803 0 0
IRE1alpha activates chaperones R-HSA-381070 1.829291e-01 0.738 0 0
Interleukin-1 family signaling R-HSA-446652 1.727568e-01 0.763 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.140714e-01 0.669 0 0
Type I hemidesmosome assembly R-HSA-446107 2.143293e-01 0.669 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 2.143293e-01 0.669 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 2.143293e-01 0.669 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 2.143293e-01 0.669 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 2.143293e-01 0.669 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 2.143293e-01 0.669 0 0
TGFBR3 PTM regulation R-HSA-9839383 2.143293e-01 0.669 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 2.143293e-01 0.669 0 0
Cellular response to hypoxia R-HSA-1234174 2.164734e-01 0.665 0 0
Leishmania infection R-HSA-9658195 2.186247e-01 0.660 0 0
Parasitic Infection Pathways R-HSA-9824443 2.186247e-01 0.660 0 0
Regulation of insulin secretion R-HSA-422356 2.186369e-01 0.660 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 2.190044e-01 0.660 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 2.190044e-01 0.660 0 0
Vpu mediated degradation of CD4 R-HSA-180534 2.190044e-01 0.660 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.190044e-01 0.660 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 2.190044e-01 0.660 0 0
HATs acetylate histones R-HSA-3214847 2.232286e-01 0.651 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.232286e-01 0.651 0 0
Circadian clock R-HSA-9909396 2.267006e-01 0.645 0 0
RAF activation R-HSA-5673000 2.270226e-01 0.644 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 2.270226e-01 0.644 0 0
Nuclear import of Rev protein R-HSA-180746 2.270226e-01 0.644 0 0
Mitophagy R-HSA-5205647 2.270226e-01 0.644 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 2.270226e-01 0.644 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 2.270226e-01 0.644 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 2.270226e-01 0.644 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 2.270226e-01 0.644 0 0
ABC-family proteins mediated transport R-HSA-382556 2.278453e-01 0.642 0 0
DNA Double Strand Break Response R-HSA-5693606 2.278816e-01 0.642 0 0
G-protein mediated events R-HSA-112040 2.278816e-01 0.642 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 2.313770e-01 0.636 0 0
Lipophagy R-HSA-9613354 2.313770e-01 0.636 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 2.313770e-01 0.636 0 0
mRNA Editing R-HSA-75072 2.313770e-01 0.636 0 0
ARMS-mediated activation R-HSA-170984 2.313770e-01 0.636 0 0
MAPK1 (ERK2) activation R-HSA-112411 2.313770e-01 0.636 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 2.313770e-01 0.636 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 2.313770e-01 0.636 0 0
Regulated proteolysis of p75NTR R-HSA-193692 2.313770e-01 0.636 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 2.313770e-01 0.636 0 0
Transcription of the HIV genome R-HSA-167172 2.336281e-01 0.631 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.336281e-01 0.631 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 2.350611e-01 0.629 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 2.350611e-01 0.629 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 2.350611e-01 0.629 0 0
Signalling to ERKs R-HSA-187687 2.350611e-01 0.629 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 2.431155e-01 0.614 0 0
Calmodulin induced events R-HSA-111933 2.431155e-01 0.614 0 0
CaM pathway R-HSA-111997 2.431155e-01 0.614 0 0
Triglyceride catabolism R-HSA-163560 2.431155e-01 0.614 0 0
Regulation of TP53 Degradation R-HSA-6804757 2.431155e-01 0.614 0 0
RUNX2 regulates bone development R-HSA-8941326 2.431155e-01 0.614 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.439394e-01 0.613 0 0
Extracellular matrix organization R-HSA-1474244 2.445355e-01 0.612 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 2.480557e-01 0.605 0 0
Interleukin-27 signaling R-HSA-9020956 2.480557e-01 0.605 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 2.480557e-01 0.605 0 0
MAPK3 (ERK1) activation R-HSA-110056 2.480557e-01 0.605 0 0
Josephin domain DUBs R-HSA-5689877 2.480557e-01 0.605 0 0
Signal attenuation R-HSA-74749 2.480557e-01 0.605 0 0
Receptor Mediated Mitophagy R-HSA-8934903 2.480557e-01 0.605 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 2.488889e-01 0.604 0 0
Regulation of mitotic cell cycle R-HSA-453276 2.510152e-01 0.600 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 2.510152e-01 0.600 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.511811e-01 0.600 0 0
Degradation of DVL R-HSA-4641258 2.511811e-01 0.600 0 0
Degradation of AXIN R-HSA-4641257 2.511811e-01 0.600 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 2.511811e-01 0.600 0 0
RSV-host interactions R-HSA-9833110 2.512703e-01 0.600 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 2.568538e-01 0.590 0 0
PTEN Regulation R-HSA-6807070 2.589624e-01 0.587 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.592538e-01 0.586 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 2.592538e-01 0.586 0 0
Switching of origins to a post-replicative state R-HSA-69052 2.627109e-01 0.581 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 2.630721e-01 0.580 0 0
Parasite infection R-HSA-9664407 2.630721e-01 0.580 0 0
Leishmania phagocytosis R-HSA-9664417 2.630721e-01 0.580 0 0
vRNP Assembly R-HSA-192905 2.643735e-01 0.578 0 0
Chylomicron assembly R-HSA-8963888 2.643735e-01 0.578 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 2.643735e-01 0.578 0 0
Suppression of apoptosis R-HSA-9635465 2.643735e-01 0.578 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 2.643735e-01 0.578 0 0
Dissolution of Fibrin Clot R-HSA-75205 2.643735e-01 0.578 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 2.673294e-01 0.573 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 2.673294e-01 0.573 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.673294e-01 0.573 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 2.673294e-01 0.573 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 2.673294e-01 0.573 0 0
Pentose phosphate pathway R-HSA-71336 2.673294e-01 0.573 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.673294e-01 0.573 0 0
Stabilization of p53 R-HSA-69541 2.673294e-01 0.573 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 2.673294e-01 0.573 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.685846e-01 0.571 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 2.744734e-01 0.561 0 0
DNA Replication Pre-Initiation R-HSA-69002 2.751730e-01 0.560 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 2.754040e-01 0.560 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 2.754040e-01 0.560 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 2.754040e-01 0.560 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 2.754040e-01 0.560 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 2.803382e-01 0.552 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 2.803382e-01 0.552 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 2.803382e-01 0.552 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 2.803382e-01 0.552 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 2.803382e-01 0.552 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 2.803382e-01 0.552 0 0
Signaling by NOTCH1 R-HSA-1980143 2.803754e-01 0.552 0 0
UCH proteinases R-HSA-5689603 2.803754e-01 0.552 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 2.834740e-01 0.547 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 2.834740e-01 0.547 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 2.834740e-01 0.547 0 0
FLT3 Signaling R-HSA-9607240 2.834740e-01 0.547 0 0
Degradation of CRY and PER proteins R-HSA-9932298 2.915357e-01 0.535 0 0
ABC transporter disorders R-HSA-5619084 2.922125e-01 0.534 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 2.959574e-01 0.529 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 2.959574e-01 0.529 0 0
GRB2 events in EGFR signaling R-HSA-179812 2.959574e-01 0.529 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 2.959574e-01 0.529 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 2.959574e-01 0.529 0 0
Interleukin-35 Signalling R-HSA-8984722 2.959574e-01 0.529 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.959574e-01 0.529 0 0
Sensory processing of sound R-HSA-9659379 2.981443e-01 0.526 0 0
Ca-dependent events R-HSA-111996 2.995856e-01 0.523 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 2.995856e-01 0.523 0 0
Depyrimidination R-HSA-73928 2.995856e-01 0.523 0 0
Signaling by MET R-HSA-6806834 3.040829e-01 0.517 0 0
TBC/RABGAPs R-HSA-8854214 3.076206e-01 0.512 0 0
Signaling by FGFR4 R-HSA-5654743 3.076206e-01 0.512 0 0
MITF-M-dependent gene expression R-HSA-9856651 3.091373e-01 0.510 0 0
Processing of DNA double-strand break ends R-HSA-5693607 3.100267e-01 0.509 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 3.112386e-01 0.507 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 3.112386e-01 0.507 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 3.112386e-01 0.507 0 0
Frs2-mediated activation R-HSA-170968 3.112386e-01 0.507 0 0
Maturation of nucleoprotein R-HSA-9683610 3.112386e-01 0.507 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 3.112386e-01 0.507 0 0
Proteasome assembly R-HSA-9907900 3.156374e-01 0.501 0 0
Netrin-1 signaling R-HSA-373752 3.156374e-01 0.501 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 3.159742e-01 0.500 0 0
rRNA processing R-HSA-72312 3.171718e-01 0.499 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 3.176449e-01 0.498 0 0
Nucleosome assembly R-HSA-774815 3.236332e-01 0.490 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 3.236332e-01 0.490 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 3.236332e-01 0.490 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 3.236332e-01 0.490 0 0
DAG and IP3 signaling R-HSA-1489509 3.236332e-01 0.490 0 0
Signaling by FGFR3 R-HSA-5654741 3.236332e-01 0.490 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 3.236332e-01 0.490 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 3.236332e-01 0.490 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 3.236332e-01 0.490 0 0
Somitogenesis R-HSA-9824272 3.236332e-01 0.490 0 0
Mitochondrial biogenesis R-HSA-1592230 3.239320e-01 0.490 0 0
Death Receptor Signaling R-HSA-73887 3.261814e-01 0.487 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 3.261890e-01 0.487 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 3.261890e-01 0.487 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 3.261890e-01 0.487 0 0
NRIF signals cell death from the nucleus R-HSA-205043 3.261890e-01 0.487 0 0
HDL assembly R-HSA-8963896 3.261890e-01 0.487 0 0
Signal regulatory protein family interactions R-HSA-391160 3.261890e-01 0.487 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 3.278741e-01 0.484 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 3.316050e-01 0.479 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 3.316050e-01 0.479 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 3.316050e-01 0.479 0 0
Regulation of pyruvate metabolism R-HSA-9861718 3.316050e-01 0.479 0 0
Signaling by TGFBR3 R-HSA-9839373 3.316050e-01 0.479 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 3.316050e-01 0.479 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 3.316050e-01 0.479 0 0
Meiosis R-HSA-1500620 3.338237e-01 0.476 0 0
Protein-protein interactions at synapses R-HSA-6794362 3.338237e-01 0.476 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 3.395501e-01 0.469 0 0
SHC1 events in EGFR signaling R-HSA-180336 3.408157e-01 0.467 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 3.408157e-01 0.467 0 0
p38MAPK events R-HSA-171007 3.408157e-01 0.467 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 3.408157e-01 0.467 0 0
Protein lipoylation R-HSA-9857492 3.408157e-01 0.467 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 3.408157e-01 0.467 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 3.408157e-01 0.467 0 0
Chromosome Maintenance R-HSA-73886 3.436301e-01 0.464 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 3.457153e-01 0.461 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 3.474660e-01 0.459 0 0
Co-inhibition by PD-1 R-HSA-389948 3.488883e-01 0.457 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 3.551259e-01 0.450 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 3.551259e-01 0.450 0 0
Prolonged ERK activation events R-HSA-169893 3.551259e-01 0.450 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 3.551259e-01 0.450 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 3.551259e-01 0.450 0 0
Negative regulation of FLT3 R-HSA-9706369 3.551259e-01 0.450 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 3.551259e-01 0.450 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 3.551259e-01 0.450 0 0
Activation of SMO R-HSA-5635838 3.551259e-01 0.450 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 3.551259e-01 0.450 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 3.551259e-01 0.450 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 3.551259e-01 0.450 0 0
Attachment and Entry R-HSA-9678110 3.551259e-01 0.450 0 0
Regulation of RAS by GAPs R-HSA-5658442 3.632002e-01 0.440 0 0
Metabolism of proteins R-HSA-392499 3.642821e-01 0.439 0 0
G1/S Transition R-HSA-69206 3.682877e-01 0.434 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 3.691262e-01 0.433 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 3.691262e-01 0.433 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 3.691262e-01 0.433 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 3.691262e-01 0.433 0 0
Passive transport by Aquaporins R-HSA-432047 3.691262e-01 0.433 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 3.691262e-01 0.433 0 0
Meiotic recombination R-HSA-912446 3.710140e-01 0.431 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 3.710140e-01 0.431 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 3.710140e-01 0.431 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 3.732158e-01 0.428 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 3.787894e-01 0.422 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 3.787894e-01 0.422 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 3.787894e-01 0.422 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 3.828234e-01 0.417 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 3.828234e-01 0.417 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 3.828234e-01 0.417 0 0
Uptake and function of anthrax toxins R-HSA-5210891 3.828234e-01 0.417 0 0
Meiotic synapsis R-HSA-1221632 3.865244e-01 0.413 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 3.865244e-01 0.413 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 3.865244e-01 0.413 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 3.865244e-01 0.413 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 3.865244e-01 0.413 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 3.871175e-01 0.412 0 0
Assembly of the pre-replicative complex R-HSA-68867 3.929881e-01 0.406 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 3.942170e-01 0.404 0 0
Adaptive Immune System R-HSA-1280218 3.948902e-01 0.404 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 3.962241e-01 0.402 0 0
Presynaptic function of Kainate receptors R-HSA-500657 3.962241e-01 0.402 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 3.962241e-01 0.402 0 0
Deubiquitination R-HSA-5688426 3.982910e-01 0.400 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 4.018656e-01 0.396 0 0
G alpha (s) signalling events R-HSA-418555 4.035641e-01 0.394 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 4.046851e-01 0.393 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 4.093346e-01 0.388 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 4.093346e-01 0.388 0 0
STING mediated induction of host immune responses R-HSA-1834941 4.093346e-01 0.388 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 4.093346e-01 0.388 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 4.093346e-01 0.388 0 0
Translesion Synthesis by POLH R-HSA-110320 4.093346e-01 0.388 0 0
Maturation of nucleoprotein R-HSA-9694631 4.093346e-01 0.388 0 0
Other interleukin signaling R-HSA-449836 4.093346e-01 0.388 0 0
NRAGE signals death through JNK R-HSA-193648 4.094683e-01 0.388 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 4.094683e-01 0.388 0 0
Signaling by FGFR1 R-HSA-5654736 4.094683e-01 0.388 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 4.094683e-01 0.388 0 0
Ub-specific processing proteases R-HSA-5689880 4.121460e-01 0.385 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 4.163161e-01 0.381 0 0
Telomere Maintenance R-HSA-157579 4.221044e-01 0.375 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 4.221612e-01 0.375 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 4.221612e-01 0.375 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 4.221612e-01 0.375 0 0
Nephrin family interactions R-HSA-373753 4.221612e-01 0.375 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 4.245299e-01 0.372 0 0
Integration of energy metabolism R-HSA-163685 4.319245e-01 0.365 0 0
Triglyceride metabolism R-HSA-8979227 4.319859e-01 0.365 0 0
Regulation of beta-cell development R-HSA-186712 4.319859e-01 0.365 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 4.347101e-01 0.362 0 0
Signalling to RAS R-HSA-167044 4.347101e-01 0.362 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 4.347101e-01 0.362 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 4.347101e-01 0.362 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 4.347101e-01 0.362 0 0
Basigin interactions R-HSA-210991 4.347101e-01 0.362 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 4.393901e-01 0.357 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 4.393901e-01 0.357 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 4.393901e-01 0.357 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 4.393901e-01 0.357 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 4.393901e-01 0.357 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 4.393901e-01 0.357 0 0
Regulation of PTEN gene transcription R-HSA-8943724 4.393901e-01 0.357 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 4.393901e-01 0.357 0 0
Metabolism of polyamines R-HSA-351202 4.393901e-01 0.357 0 0
Unfolded Protein Response (UPR) R-HSA-381119 4.463974e-01 0.350 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 4.469872e-01 0.350 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 4.469872e-01 0.350 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 4.469872e-01 0.350 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 4.469872e-01 0.350 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 4.469872e-01 0.350 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 4.469872e-01 0.350 0 0
Attachment and Entry R-HSA-9694614 4.469872e-01 0.350 0 0
Ribavirin ADME R-HSA-9755088 4.469872e-01 0.350 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 4.507362e-01 0.346 0 0
DNA Repair R-HSA-73894 4.539748e-01 0.343 0 0
tRNA processing in the nucleus R-HSA-6784531 4.540384e-01 0.343 0 0
Signaling by PDGF R-HSA-186797 4.540384e-01 0.343 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 4.540384e-01 0.343 0 0
Heme signaling R-HSA-9707616 4.540384e-01 0.343 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 4.589983e-01 0.338 0 0
Notch-HLH transcription pathway R-HSA-350054 4.589983e-01 0.338 0 0
LDL clearance R-HSA-8964038 4.589983e-01 0.338 0 0
Complex I biogenesis R-HSA-6799198 4.612802e-01 0.336 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 4.612802e-01 0.336 0 0
Opioid Signalling R-HSA-111885 4.620285e-01 0.335 0 0
Activation of HOX genes during differentiation R-HSA-5619507 4.676370e-01 0.330 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 4.676370e-01 0.330 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 4.684656e-01 0.329 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 4.707494e-01 0.327 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 4.707494e-01 0.327 0 0
Termination of O-glycan biosynthesis R-HSA-977068 4.707494e-01 0.327 0 0
Interleukin-20 family signaling R-HSA-8854691 4.707494e-01 0.327 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 4.707494e-01 0.327 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 4.707494e-01 0.327 0 0
Nucleotide Excision Repair R-HSA-5696398 4.732196e-01 0.325 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 4.822459e-01 0.317 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 4.822459e-01 0.317 0 0
Complex III assembly R-HSA-9865881 4.822459e-01 0.317 0 0
Mitochondrial RNA degradation R-HSA-9836573 4.822459e-01 0.317 0 0
Neurodegenerative Diseases R-HSA-8863678 4.822459e-01 0.317 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 4.822459e-01 0.317 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 4.826637e-01 0.316 0 0
Chromatin modifying enzymes R-HSA-3247509 4.834729e-01 0.316 0 0
Synthesis of DNA R-HSA-69239 4.843039e-01 0.315 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 4.843039e-01 0.315 0 0
Signaling by ALK in cancer R-HSA-9700206 4.843039e-01 0.315 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 4.934933e-01 0.307 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 4.934933e-01 0.307 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 4.934933e-01 0.307 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 4.934933e-01 0.307 0 0
Sema4D in semaphorin signaling R-HSA-400685 4.934933e-01 0.307 0 0
S Phase R-HSA-69242 4.937308e-01 0.307 0 0
Regulated Necrosis R-HSA-5218859 4.966258e-01 0.304 0 0
Gastrulation R-HSA-9758941 4.983740e-01 0.302 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 5.044971e-01 0.297 0 0
MET activates PTK2 signaling R-HSA-8874081 5.044971e-01 0.297 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 5.044971e-01 0.297 0 0
Asparagine N-linked glycosylation R-HSA-446203 5.067279e-01 0.295 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 5.103459e-01 0.292 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 5.103459e-01 0.292 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 5.103459e-01 0.292 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 5.103459e-01 0.292 0 0
FCERI mediated MAPK activation R-HSA-2871796 5.115126e-01 0.291 0 0
Inositol phosphate metabolism R-HSA-1483249 5.115126e-01 0.291 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 5.152625e-01 0.288 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 5.152625e-01 0.288 0 0
Packaging Of Telomere Ends R-HSA-171306 5.152625e-01 0.288 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 5.152625e-01 0.288 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 5.152625e-01 0.288 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 5.152625e-01 0.288 0 0
Insulin processing R-HSA-264876 5.152625e-01 0.288 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 5.152625e-01 0.288 0 0
Maturation of hRSV A proteins R-HSA-9828806 5.152625e-01 0.288 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 5.152625e-01 0.288 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 5.152625e-01 0.288 0 0
DNA Double-Strand Break Repair R-HSA-5693532 5.167605e-01 0.287 0 0
Protein localization R-HSA-9609507 5.167605e-01 0.287 0 0
DNA Replication R-HSA-69306 5.167605e-01 0.287 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 5.171136e-01 0.286 0 0
Metabolism of cofactors R-HSA-8978934 5.171136e-01 0.286 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 5.221832e-01 0.282 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 5.238190e-01 0.281 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 5.257947e-01 0.279 0 0
HIV elongation arrest and recovery R-HSA-167287 5.257947e-01 0.279 0 0
Formation of the Early Elongation Complex R-HSA-113418 5.257947e-01 0.279 0 0
Pausing and recovery of HIV elongation R-HSA-167290 5.257947e-01 0.279 0 0
Insulin receptor recycling R-HSA-77387 5.257947e-01 0.279 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 5.257947e-01 0.279 0 0
Telomere Extension By Telomerase R-HSA-171319 5.257947e-01 0.279 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 5.257947e-01 0.279 0 0
DNA methylation R-HSA-5334118 5.360987e-01 0.271 0 0
Late endosomal microautophagy R-HSA-9615710 5.360987e-01 0.271 0 0
mRNA Capping R-HSA-72086 5.360987e-01 0.271 0 0
Thyroxine biosynthesis R-HSA-209968 5.360987e-01 0.271 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 5.360987e-01 0.271 0 0
Glucagon-type ligand receptors R-HSA-420092 5.360987e-01 0.271 0 0
Regulation of gene expression in beta cells R-HSA-210745 5.360987e-01 0.271 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 5.363805e-01 0.271 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 5.368691e-01 0.270 0 0
Interferon alpha/beta signaling R-HSA-909733 5.379478e-01 0.269 0 0
Chromatin organization R-HSA-4839726 5.388477e-01 0.269 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 5.435570e-01 0.265 0 0
Protein ubiquitination R-HSA-8852135 5.435570e-01 0.265 0 0
DAP12 signaling R-HSA-2424491 5.461793e-01 0.263 0 0
Activation of the pre-replicative complex R-HSA-68962 5.461793e-01 0.263 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 5.461793e-01 0.263 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 5.461793e-01 0.263 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 5.461793e-01 0.263 0 0
Bacterial Infection Pathways R-HSA-9824439 5.473440e-01 0.262 0 0
Regulation of TP53 Activity R-HSA-5633007 5.481577e-01 0.261 0 0
Homology Directed Repair R-HSA-5693538 5.534125e-01 0.257 0 0
Budding and maturation of HIV virion R-HSA-162588 5.560416e-01 0.255 0 0
Downstream signal transduction R-HSA-186763 5.560416e-01 0.255 0 0
Translation of Structural Proteins R-HSA-9694635 5.563966e-01 0.255 0 0
G alpha (12/13) signalling events R-HSA-416482 5.627198e-01 0.250 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 5.656901e-01 0.247 0 0
G0 and Early G1 R-HSA-1538133 5.656901e-01 0.247 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 5.685666e-01 0.245 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 5.689783e-01 0.245 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 5.751295e-01 0.240 0 0
Activation of ATR in response to replication stress R-HSA-176187 5.751295e-01 0.240 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 5.751295e-01 0.240 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 5.751295e-01 0.240 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 5.751295e-01 0.240 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 5.813005e-01 0.236 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 5.843643e-01 0.233 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 5.931099e-01 0.227 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 5.931099e-01 0.227 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 5.931099e-01 0.227 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 5.933622e-01 0.227 0 0
Cytoprotection by HMOX1 R-HSA-9707564 5.933622e-01 0.227 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 5.933989e-01 0.227 0 0
Signaling by NOTCH2 R-HSA-1980145 5.933989e-01 0.227 0 0
Signal amplification R-HSA-392518 5.933989e-01 0.227 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 5.933989e-01 0.227 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 5.992953e-01 0.222 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 6.022377e-01 0.220 0 0
Oncogene Induced Senescence R-HSA-2559585 6.022377e-01 0.220 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 6.075832e-01 0.216 0 0
Leishmania parasite growth and survival R-HSA-9664433 6.075832e-01 0.216 0 0
PRC2 methylates histones and DNA R-HSA-212300 6.108849e-01 0.214 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 6.108849e-01 0.214 0 0
FGFR2 mutant receptor activation R-HSA-1839126 6.108849e-01 0.214 0 0
GPVI-mediated activation cascade R-HSA-114604 6.108849e-01 0.214 0 0
FLT3 signaling in disease R-HSA-9682385 6.108849e-01 0.214 0 0
Amplification of signal from the kinetochores R-HSA-141424 6.109658e-01 0.214 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 6.109658e-01 0.214 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 6.167034e-01 0.210 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 6.167034e-01 0.210 0 0
Voltage gated Potassium channels R-HSA-1296072 6.193447e-01 0.208 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 6.193447e-01 0.208 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 6.193447e-01 0.208 0 0
Cleavage of the damaged purine R-HSA-110331 6.193447e-01 0.208 0 0
Ovarian tumor domain proteases R-HSA-5689896 6.193447e-01 0.208 0 0
Reproduction R-HSA-1474165 6.213461e-01 0.207 0 0
Adipogenesis R-HSA-9843745 6.259206e-01 0.203 0 0
MET promotes cell motility R-HSA-8875878 6.276210e-01 0.202 0 0
Depurination R-HSA-73927 6.276210e-01 0.202 0 0
Diseases of programmed cell death R-HSA-9645723 6.279835e-01 0.202 0 0
ER-Phagosome pathway R-HSA-1236974 6.335263e-01 0.198 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 6.357178e-01 0.197 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 6.357178e-01 0.197 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 6.357178e-01 0.197 0 0
Plasma lipoprotein clearance R-HSA-8964043 6.357178e-01 0.197 0 0
Signaling by ALK R-HSA-201556 6.357178e-01 0.197 0 0
Base Excision Repair R-HSA-73884 6.390045e-01 0.194 0 0
Downstream TCR signaling R-HSA-202424 6.390045e-01 0.194 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 6.436391e-01 0.191 0 0
HIV Transcription Elongation R-HSA-167169 6.436391e-01 0.191 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 6.436391e-01 0.191 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 6.436391e-01 0.191 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 6.436391e-01 0.191 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 6.436391e-01 0.191 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 6.436391e-01 0.191 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 6.444182e-01 0.191 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 6.513887e-01 0.186 0 0
Maturation of spike protein R-HSA-9694548 6.513887e-01 0.186 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 6.513887e-01 0.186 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 6.513887e-01 0.186 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 6.550533e-01 0.184 0 0
Intra-Golgi traffic R-HSA-6811438 6.589701e-01 0.181 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 6.589701e-01 0.181 0 0
Translation of Structural Proteins R-HSA-9683701 6.589701e-01 0.181 0 0
FCGR activation R-HSA-2029481 6.602751e-01 0.180 0 0
Mitochondrial protein degradation R-HSA-9837999 6.654335e-01 0.177 0 0
Collagen formation R-HSA-1474290 6.654335e-01 0.177 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 6.663872e-01 0.176 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 6.663872e-01 0.176 0 0
Defective pyroptosis R-HSA-9710421 6.736434e-01 0.172 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 6.736434e-01 0.172 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 6.805307e-01 0.167 0 0
DAP12 interactions R-HSA-2172127 6.807422e-01 0.167 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 6.876870e-01 0.163 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 6.944812e-01 0.158 0 0
Regulation of TNFR1 signaling R-HSA-5357905 6.944812e-01 0.158 0 0
Disorders of transmembrane transporters R-HSA-5619115 6.969621e-01 0.157 0 0
Mitotic Spindle Checkpoint R-HSA-69618 6.997912e-01 0.155 0 0
Interleukin-1 signaling R-HSA-9020702 7.044536e-01 0.152 0 0
Signaling by NTRKs R-HSA-166520 7.055669e-01 0.151 0 0
Plasma lipoprotein remodeling R-HSA-8963899 7.076305e-01 0.150 0 0
Regulation of endogenous retroelements R-HSA-9842860 7.090556e-01 0.149 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 7.139920e-01 0.146 0 0
DNA Damage Bypass R-HSA-73893 7.139920e-01 0.146 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 7.139920e-01 0.146 0 0
Azathioprine ADME R-HSA-9748787 7.202154e-01 0.143 0 0
Signaling by FGFR2 in disease R-HSA-5655253 7.202154e-01 0.143 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 7.263038e-01 0.139 0 0
Branched-chain amino acid catabolism R-HSA-70895 7.263038e-01 0.139 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 7.268691e-01 0.139 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 7.278577e-01 0.138 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 7.322601e-01 0.135 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 7.322601e-01 0.135 0 0
Neurexins and neuroligins R-HSA-6794361 7.322601e-01 0.135 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 7.322601e-01 0.135 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 7.380871e-01 0.132 0 0
Amino acids regulate mTORC1 R-HSA-9639288 7.380871e-01 0.132 0 0
Antigen processing-Cross presentation R-HSA-1236975 7.396172e-01 0.131 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 7.419716e-01 0.130 0 0
MyD88-independent TLR4 cascade R-HSA-166166 7.478315e-01 0.126 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 7.478315e-01 0.126 0 0
Signaling by TGFB family members R-HSA-9006936 7.488080e-01 0.126 0 0
HDACs deacetylate histones R-HSA-3214815 7.493645e-01 0.125 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 7.548203e-01 0.122 0 0
Metabolism of amine-derived hormones R-HSA-209776 7.548203e-01 0.122 0 0
TNF signaling R-HSA-75893 7.548203e-01 0.122 0 0
Ion homeostasis R-HSA-5578775 7.548203e-01 0.122 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 7.597359e-01 0.119 0 0
Dectin-2 family R-HSA-5621480 7.601576e-01 0.119 0 0
Dual incision in TC-NER R-HSA-6782135 7.653791e-01 0.116 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 7.653791e-01 0.116 0 0
Extension of Telomeres R-HSA-180786 7.704872e-01 0.113 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 7.704872e-01 0.113 0 0
Neddylation R-HSA-8951664 7.746290e-01 0.111 0 0
tRNA Aminoacylation R-HSA-379724 7.754844e-01 0.110 0 0
Peptide hormone metabolism R-HSA-2980736 7.820929e-01 0.107 0 0
NCAM signaling for neurite out-growth R-HSA-375165 7.851557e-01 0.105 0 0
Insulin receptor signalling cascade R-HSA-74751 7.944115e-01 0.100 0 0
Formation of the cornified envelope R-HSA-6809371 8.058550e-01 0.094 0 0
O-linked glycosylation of mucins R-HSA-913709 8.117471e-01 0.091 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 8.117471e-01 0.091 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 8.117471e-01 0.091 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 8.198602e-01 0.086 0 0
COPII-mediated vesicle transport R-HSA-204005 8.198602e-01 0.086 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 8.213918e-01 0.085 0 0
Post-translational protein modification R-HSA-597592 8.225087e-01 0.085 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 8.237851e-01 0.084 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 8.237851e-01 0.084 0 0
Metabolism of amino acids and derivatives R-HSA-71291 8.301787e-01 0.081 0 0
Ca2+ pathway R-HSA-4086398 8.313809e-01 0.080 0 0
GPCR downstream signalling R-HSA-388396 8.324913e-01 0.080 0 0
Signaling by FGFR in disease R-HSA-1226099 8.350554e-01 0.078 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 8.421666e-01 0.075 0 0
Interleukin-10 signaling R-HSA-6783783 8.489721e-01 0.071 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 8.489721e-01 0.071 0 0
RNA Polymerase I Transcription R-HSA-73864 8.489721e-01 0.071 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 8.522643e-01 0.069 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 8.554850e-01 0.068 0 0
Amyloid fiber formation R-HSA-977225 8.586356e-01 0.066 0 0
G alpha (q) signalling events R-HSA-416476 8.700999e-01 0.060 0 0
FCERI mediated NF-kB activation R-HSA-2871837 8.707420e-01 0.060 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 8.793921e-01 0.056 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 8.835142e-01 0.054 0 0
Neurotransmitter release cycle R-HSA-112310 8.866092e-01 0.052 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 8.866092e-01 0.052 0 0
PPARA activates gene expression R-HSA-1989781 8.932568e-01 0.049 0 0
Signaling by Insulin receptor R-HSA-74752 8.938702e-01 0.049 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 8.961860e-01 0.048 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.969379e-01 0.047 0 0
HCMV Late Events R-HSA-9610379 8.969379e-01 0.047 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.006675e-01 0.045 0 0
Potassium Channels R-HSA-1296071 9.049560e-01 0.043 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 9.070305e-01 0.042 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.090599e-01 0.041 0 0
SLC transporter disorders R-HSA-5619102 9.136359e-01 0.039 0 0
Signaling by GPCR R-HSA-372790 9.166051e-01 0.038 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.185630e-01 0.037 0 0
tRNA processing R-HSA-72306 9.195775e-01 0.036 0 0
Metabolism of nucleotides R-HSA-15869 9.199520e-01 0.036 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.211975e-01 0.036 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.220808e-01 0.035 0 0
Stimuli-sensing channels R-HSA-2672351 9.286684e-01 0.032 0 0
Respiratory electron transport R-HSA-611105 9.303272e-01 0.031 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.388883e-01 0.027 0 0
Peptide ligand-binding receptors R-HSA-375276 9.397110e-01 0.027 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.415303e-01 0.026 0 0
Epigenetic regulation of gene expression R-HSA-212165 9.434410e-01 0.025 0 0
Toll-like Receptor Cascades R-HSA-168898 9.449539e-01 0.025 0 0
Keratinization R-HSA-6805567 9.589699e-01 0.018 0 0
Cardiac conduction R-HSA-5576891 9.607279e-01 0.017 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.615872e-01 0.017 0 0
O-linked glycosylation R-HSA-5173105 9.663633e-01 0.015 0 0
Mitochondrial translation R-HSA-5368287 9.670997e-01 0.015 0 0
G alpha (i) signalling events R-HSA-418594 9.848025e-01 0.007 0 0
Diseases of glycosylation R-HSA-3781865 9.886476e-01 0.005 0 0
Ion channel transport R-HSA-983712 9.898406e-01 0.004 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.903021e-01 0.004 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.906843e-01 0.004 0 0
Drug ADME R-HSA-9748784 9.947851e-01 0.002 0 0
Metabolism of steroids R-HSA-8957322 9.957409e-01 0.002 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.960075e-01 0.002 0 0
Phase II - Conjugation of compounds R-HSA-156580 9.967327e-01 0.001 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.986311e-01 0.001 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.987166e-01 0.001 0 0
Transport of small molecules R-HSA-382551 9.988159e-01 0.001 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.989727e-01 0.000 0 0
Diseases of metabolism R-HSA-5668914 9.994754e-01 0.000 0 0
GPCR ligand binding R-HSA-500792 9.998664e-01 0.000 0 0
Fatty acid metabolism R-HSA-8978868 9.999258e-01 0.000 0 0
Biological oxidations R-HSA-211859 9.999281e-01 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways