SGK2

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A5A3E0 S939 Sugiyama POTEF A26C1B VALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPE
O14617 S658 Sugiyama AP3D1 PRO0039 DERPRAVFHEEEQRRPKHRPsEADEEELARRREARKQEQAN
O14974 S910 Sugiyama PPP1R12A MBS MYPT1 yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O15530 S176 Sugiyama PDPK1 PDK1 YFGLSYAKNGELLKYIRKIGsFDETCTRFYTAEIVSALEYL
O43175 T78 Sugiyama PHGDH PGDH3 KVTADVINAAEKLQVVGRAGtGVDNVDLEAAtRKGILVMNT
O43390 S428 Sugiyama HNRNPR HNRPR LAKPPDKKRKERQAARQAsRstAyEDyyyHPPPRMPPPIRG
O43524 S253 SIGNOR|ELM FOXO3 FKHRL1 FOXO3A WWIINPDGGKsGKAPRRRAVsMDNsNKYTKSRGRAAKKKAA
O43524 S315 ELM FOXO3 FKHRL1 FOXO3A PtSRssDELDAWTDFRsRTNsNAsTVsGRLSPIMAsTELDE
O43524 T32 SIGNOR|ELM FOXO3 FKHRL1 FOXO3A sPLEVELDPEFEPQSRPRsCtWPLQRPELQAsPAKPSGETA
O43707 T69 Sugiyama ACTN4 EKQQRKTFTAWCNsHLRKAGtQIENIDEDFRDGLKLMLLLE
O43847 S96 Sugiyama NRDC NRD1 SRVARLGADEsEEEGRRGsLsNAGDPEIVKsPsDPKQYRYI
O43852 S44 Sugiyama CALU KKDRVHHEPQLsDKVHNDAQsFDyDHDAFLGAEEAKtFDQL
O60220 S94 Sugiyama TIMM8A DDP DDP1 TIM8A SQFILNRLEQTQKSKPVFSEsLsD_________________
O60271 T595 Sugiyama SPAG9 HSS KIAA0516 MAPK8IP4 SYD1 HLC6 NLKYNAPTSHVtPsVKKRsstLsQLPGDKSKAFDFLSEETE
O60293 S42 Sugiyama ZFC3H1 CCDC131 KIAA0546 PSRC2 LEDGEIsDDDNNSQIRSRsssSsSGGGLLPYPRRRPPHSAR
O60343 S588 Sugiyama TBC1D4 AS160 KIAA0603 tssLENIFSRGANRMRGRLGsVDsFERsNsLASEKDYsPGD
O60739 T45 Sugiyama EIF1B AGTEDyIHIRIQQRNGRKtLttVQGIADDyDKKKLVKAFKK
O60814 S37 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
O60814 S39 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
O60841 S107 Sugiyama EIF5B IF2 KIAA0741 NEEEFtsKDKKKKGQKGKKQsFDDNDsEELEDKDsKSKKTA
O60841 S182 Sugiyama EIF5B IF2 KIAA0741 DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O60841 S186 Sugiyama EIF5B IF2 KIAA0741 EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O75369 S1442 Sugiyama FLNB FLN1L FLN3 TABP TAP SKVKIAGPGLGsGVRARVLQsFtVDSSKAGLAPLEVRVLGP
O75937 S81 Sugiyama DNAJC8 SPF31 HSPC315 HSPC331 VLQIDPEVTDEEIKKRFRQLsILVHPDKNQDDADRAQKAFE
O95155 S105 Sugiyama UBE4B HDNB1 KIAA0684 UFD2 LsssPsNsLEtQsQsLsRsQsMDIDGVSCEKsMsQVDVDsG
O95218 S181 Sugiyama ZRANB2 ZIS ZNF265 DEDLsKyKLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRR
P00491 S163 Sugiyama PNP NP GQNPLRGPNDERFGDRFPAMsDAyDRtMRQRALstWKQMGE
P00491 S176 Sugiyama PNP NP GDRFPAMsDAyDRtMRQRALstWKQMGEQRELQEGTYVMVA
P04075 S336 Sugiyama ALDOA ALDA GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04075 S356 Sugiyama ALDOA ALDA sLACQGKytPsGQAGAAAsEsLFVsNHAy____________
P04075 S360 Sugiyama ALDOA ALDA QGKytPsGQAGAAAsEsLFVsNHAy________________
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05362 S43 Sugiyama ICAM1 GPGNAQTSVSPSKVILPRGGsVLVTCstsCDQPKLLGIETP
P05455 S94 Sugiyama SSB KSKAELMEIsEDKTKIRRsPsKPLPEVTDEyKNDVKNRsVY
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P07195 T302 Sugiyama LDHB YGIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsAD
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07814 S739 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 TKVEATKNETSAPFKERPtPsLNNNCttsEDsLVLyNRVAV
P07900 T317 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA WtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 T309 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB WtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P08758 T8 Sugiyama ANXA5 ANX5 ENX2 PP4 _____________MAQVLRGtVtDFPGFDERADAEtLRKAM
P0CAP2 S179 Sugiyama POLR2M GRINL1A RDRVPPSSEASEHHPRHRVssQAEDtSssFDNLFIDRLQRI
P0CAP2 T184 Sugiyama POLR2M GRINL1A PSSEASEHHPRHRVssQAEDtSssFDNLFIDRLQRITIADQ
P10412 S36 Sugiyama H1-4 H1F4 HIST1H1E EKtPVKKKARKsAGAAKRKAsGPPVsELItKAVAASKERsG
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P13010 S318 Sugiyama XRCC5 G22P2 NDDDETEVLKEDIIQGFRyGsDIVPFSKVDEEQMKYKSEGK
P13639 S23 Sugiyama EEF2 EF2 NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639 S593 Sugiyama EEF2 EF2 SDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGL
P13796 S5 PSP LCP1 PLS2 ________________MARGsVsDEEMMELREAFAKVDtDG
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14625 S514 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 LGVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEK
P14625 S64 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 tDDEVVQREEEAIQLDGLNAsQIRELREKSEKFAFQAEVNR
P14625 T519 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 DHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEKQDKIy
P14866 S544 Sugiyama HNRNPL HNRPL P/OKcl.14 LGVKRPSSVKVFSGKsERsssGLLEWEsKSDALETLGFLNH
P15056 S365 ELM BRAF BRAF1 RAFB1 PFRPADEDHRNQFGQRDRsssAPNVHINtIEPVNIDDLIRD
P16402 S37 Sugiyama H1-3 H1F3 HIST1H1D KtPVKKKAKKAGATAGKRKAsGPPVsELItKAVAASKERsG
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17655 T464 Sugiyama CAPN2 CANPL2 TNIHLSKNFFLTNRARERsDtFINLREVLNRFKLPPGEYIL
P17812 S573 Sugiyama CTPS1 CTPS HYLQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD__
P18583 S2011 Sugiyama SON C21orf50 DBP5 KIAA1019 NREBP HSPC310 HSPC312 RSRTPSRRRRSRSVVRRRsFsIsPVRLRRSRTPLRRRFsRs
P18621 S5 Sugiyama RPL17 ________________MVRysLDPENPtKsCKSRGSNLRVH
P18858 S901 Sugiyama LIG1 DKQPEQATTSAQVACLYRKQsQIQNQQGEDsGsDPEDTY__
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P19338 S580 Sugiyama NCL PRGsPNARSQPSKTLFVKGLsEDttEEtLKEsFDGsVRARI
P20810 S366 Sugiyama CAST DKDGKPLLPEPEEKPKPRsEsELIDELsEDFDRsECKEKPS
P21333 S2152 Sugiyama FLNA FLN FLN1 VKVTGEGRVKEsITRRRRAPsVANVGsHCDLsLKIPEIsIQ
P23588 S207 Sugiyama EIF4B DRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYRDR
P25789 T10 Sugiyama PSMA4 HC9 PSC9 ___________MSRRyDsRttIFsPEGRLYQVEYAMEAIGH
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373 T107 Sugiyama RPL13 BBC1 OK/SW-cl.46 HKKVARTIGIsVDPRRRNKstEsLQANVQRLKEYRSKLILF
P27348 S45 Sugiyama YWHAQ CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P27708 S1859 Sugiyama CAD RGIPGLPDGRFHLPPRIHRAsDPGLPAEEPKEKSSRKVAEP
P29692 S162 Sugiyama EEF1D EF1D AKKPAtPAEDDEDDDIDLFGsDNEEEDKEAAQLREERLRQY
P30086 S52 Sugiyama PEBP1 PBP PEBP AAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPD
P30533 S242 Sugiyama LRPAP1 A2MRAP TELKEKLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWD
P31946 S47 Sugiyama YWHAB AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31947 S45 Sugiyama SFN HME1 FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P34932 S76 Sugiyama HSPA4 APG2 HSPH2 VISNAKNTVQGFKRFHGRAFsDPFVEAEKSNLAYDIVQLPT
P35269 T154 Sugiyama GTF2F1 RAP74 AFEAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHF
P35269 T156 Sugiyama GTF2F1 RAP74 EAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHFSI
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37837 S13 Sugiyama TALDO1 TAL TALDO TALDOR ________MsssPVKRQRMEsALDQLKQFTTVVADTGDFHA
P38646 S89 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P38646 T116 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P40818 S719 Sugiyama USP8 KIAA0055 UBPY KPQIPAERDREPSKLKRsyssPDItQAIQEEEKRKPTVtPT
P41567 T45 Sugiyama EIF1 SUI1 AGTEDyIHIRIQQRNGRKtLttVQGIADDyDKKKLVKAFKK
P43243 S234 Sugiyama MATR3 KIAA0723 yDRMDyEDDRLRDGERCRDDsFFGEtsHNyHKFDsEyERMG
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P47712 S727 Sugiyama PLA2G4A CPLA2 PLA2G4 VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP
P48048 S44 ELM KCNJ1 ROMK1 LRKWVVTRFFGHSRQRARLVsKDGRCNIEFGNVEAQSRFIF
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P49321 T700 Sugiyama NASP sGFtPGGGGssVsMIASRKPtDGAsssNCVTDIsHLVRKKR
P49419 S84 Sugiyama ALDH7A1 ATQ1 EVIttyCPANNEPIARVRQAsVADyEEtVKKAREAWKIWAD
P49753 T118 Sugiyama ACOT2 PTE2 PTE2A ASLRDEKGALFQAHARyRADtLGELDLERAPALGGSFAGLE
P49753 Y114 Sugiyama ACOT2 PTE2 PTE2A VTLRASLRDEKGALFQAHARyRADtLGELDLERAPALGGSF
P49841 S21 ELM GSK3B MSGRPRttsFAEsCKPVQQPsAFGsMKVSRDKDGSKVTTVV
P51116 S601 Sugiyama FXR2 FMR1L2 RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P51116 T598 Sugiyama FXR2 FMR1L2 DESRPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRA
P52298 S13 Sugiyama NCBP2 CBP20 PIG55 ________MSGGLLKALRsDsyVELSQYRDQHFRGDNEEQE
P53396 S455 Sugiyama ACLY ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P57053 S37 Sugiyama H2BC12L H2BFS H2BS1 KAVTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIss
P57053 S39 Sugiyama H2BC12L H2BFS H2BS1 VTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P58876 S37 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
P58876 S39 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P60174 S21 Sugiyama TPI1 TPI MAPSRKFFVGGNWKMNGRKQsLGELIGtLNAAKVPADtEVV
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709 S239 Sugiyama ACTB VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P61981 S46 Sugiyama YWHAG AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P62258 S46 Sugiyama YWHAE SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62736 S241 Sugiyama ACTA2 ACTSA ACTVS GIG46 VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62807 S37 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI KAVTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIss
P62807 S39 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI VTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssKA
P62906 S64 Sugiyama RPL10A NEDD6 QKDKRFsGTVRLKSTPRPKFsVCVLGDQQHCDEAKAVDIPH
P62942 T22 Sugiyama FKBP1A FKBP1 FKBP12 GVQVEtIsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRD
P63104 S45 Sugiyama YWHAZ CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261 S239 Sugiyama ACTG1 ACTG VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63267 S240 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P67809 S209 Sugiyama YBX1 NSEP1 YB1 RRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGEQ
P68032 S241 Sugiyama ACTC1 ACTC VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 S241 Sugiyama ACTA1 ACTA VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P83731 T83 Sugiyama RPL24 QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
P84098 S12 Sugiyama RPL19 _________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
Q00610 S147 Sugiyama CLTC CLH17 CLTCL2 KIAA0034 VYHWSMEGESQPVKMFDRHssLAGCQIINYRTDAKQKWLLL
Q00987 S166 PSP MDM2 KPSSSHLVSRPstSSRRRAIsEtEENsDELsGERQRKRHKs
Q04917 S46 Sugiyama YWHAH YWHA1 AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q06124 S134 Sugiyama PTPN11 PTP2C SHPTP2 HGHLSGKEAEKLLTEKGKHGsFLVREsQsHPGDFVLSVRTG
Q07020 T85 Sugiyama RPL18 RMIRKMKLPGRENKtAVVVGtItDDVRVQEVPKLKVCALRV
Q09161 S22 Sugiyama NCBP1 CBP80 NCBP SRRRHsDENDGGQPHKRRKtsDANEtEDHLEsLICKVGEKS
Q12778 S256 ELM FOXO1 FKHR FOXO1A WWMLNPEGGKSGKsPRRRAAsMDNNSKFAKSRSRAAKKKAs
Q12778 S319 ELM FOXO1 FKHR FOXO1A PGsHsNDDFDNWSTFRPRtssNAstIsGRLsPIMtEQDDLG
Q12778 T24 ELM FOXO1 FKHR FOXO1A APQVVEIDPDFEPLPRPRsCtWPLPRPEFSQSNSATSSPAP
Q12931 T494 Sugiyama TRAP1 HSP75 HSPC5 ALPsGQLtsLsEyASRMRAGtRNIyyLCAPNRHLAEHsPyy
Q12965 T936 Sugiyama MYO1E MYO1C LQVSIGPGLPKNSRPTRRNttQNtGySsGtQNANyPVRAAP
Q12982 S114 Sugiyama BNIP2 NIP2 EFEWEDDLPKPKTTEVIRKGsItEyTAAEEKEDGRRWRMFR
Q13206 S831 Sugiyama DDX10 DMENKISDTKKKQGMKKRsNsEVEDVGPTsHNRKKARWDTL
Q13439 S41 Sugiyama GOLGA4 APAQAssNsstPtRMRsRtssFtEQLDEGtPNRESGDTQSF
Q13439 T39 Sugiyama GOLGA4 ALAPAQAssNsstPtRMRsRtssFtEQLDEGtPNRESGDTQ
Q13442 S19 Sugiyama PDAP1 HASPP28 __MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEEE
Q13442 T18 Sugiyama PDAP1 HASPP28 ___MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEE
Q13501 S28 Sugiyama SQSTM1 ORCA OSIL AYLLGKEDAAREIRRFsFCCsPEPEAEAEAAAGPGPCERLL
Q13586 S618 Sugiyama STIM1 GOK ELsPsAPPGGsPHLDssRsHsPssPDPDtPsPVGDSRALQA
Q14152 S492 Sugiyama EIF3A EIF3S10 KIAA0139 VDAARHCDLQVRIDHTSRTLsFGsDLNyAtREDAPIGPHLQ
Q14152 S584 Sugiyama EIF3A EIF3S10 KIAA0139 EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV
Q14432 S312 Sugiyama PDE3A sssVVsAEMSGCSSKSHRRtsLPCIPREQLMGHSEWDHKRG
Q14432 T311 Sugiyama PDE3A RsssVVsAEMSGCSSKSHRRtsLPCIPREQLMGHSEWDHKR
Q14671 S709 Sugiyama PUM1 KIAA0099 PUMH1 LGGFGTAVANSNTGSGSRRDsLtGSsDLYKRTSSSLTPIGH
Q15080 S67 Sugiyama NCF4 SH3PXD4 TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q15642 S296 Sugiyama TRIP10 CIP4 STOT STP FARPGDVEFEDFsQPMNRAPsDssLGtPsDGRPELRGPGRS
Q15751 S1514 Sugiyama HERC1 AESRLVHtsPNYRLIKsRsEsDLsQPEsDEEGYALsGRRNV
Q16513 S583 Sugiyama PKN2 PRK2 PRKCL2 VTKLDFDLEPEPPPAPPRAssLGEIDEssELRVLDIPGQDs
Q16637 S28 Sugiyama SMN1 SMN SMNT; SMN2 SMNC sGGGVPEQEDsVLFRRGtGQsDDsDIWDDtALIKAYDKAVA
Q16637 S31 Sugiyama SMN1 SMN SMNT; SMN2 SMNC GVPEQEDsVLFRRGtGQsDDsDIWDDtALIKAYDKAVAsFK
Q3KQU3 S116 Sugiyama MAP7D1 KIAA1187 PARCC1 RPRC1 PP2464 PtPPAMGPRDARPPRRssQPsPtAVPAsDsPPtKQEVKKAG
Q4G0J3 S300 Sugiyama LARP7 HDCMA18P DRVEAssLPEVRTGKRKRsssEDAEsLAPRSKVKKIIQKDI
Q562R1 S240 Sugiyama ACTBL2 VALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPE
Q5H9R7 S579 Sugiyama PPP6R3 C11orf23 KIAA1558 PP6R3 SAPL SAPS3 IDQFGFNDEKFADQDDIGNVsFDRVSDINFTLNTNESGNIA
Q5QNW6 S37 Sugiyama H2BC18 HIST2H2BF KAVTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q5QNW6 S39 Sugiyama H2BC18 HIST2H2BF VTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q5T1M5 S1161 Sugiyama FKBP15 KIAA0674 TEAGstVAGAALRPsHHsQRssLsGDEEDELFKGATLKALR
Q5T1M5 S1162 Sugiyama FKBP15 KIAA0674 EAGstVAGAALRPsHHsQRssLsGDEEDELFKGATLKALRP
Q5VTB9 T368 Sugiyama RNF220 C1orf164 ENNNRFEEYEWCGQKRIRATtLLEGGFRGSGFIMCSGKENP
Q6A1A2 S149 Sugiyama PDPK2P PDPK2 YFGLSYAKNGELLKYIRKIGsFDETCTRFYTAEIVSALEYL
Q6S8J3 S939 Sugiyama POTEE A26C1A POTE2 VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
Q6ZN18 S206 Sugiyama AEBP2 DEGYGTGGGGSSATSGGRRGsLEMssDGEPLSRMDSEDSIS
Q86TX2 T56 Sugiyama ACOT1 CTE1 ASLRDEKGALFQAHARyRADtLGELDLERAPALGGSFAGLE
Q86TX2 Y52 Sugiyama ACOT1 CTE1 VTLRASLRDEKGALFQAHARyRADtLGELDLERAPALGGSF
Q86U44 S219 Sugiyama METTL3 MTA70 NSSASEPAKEPAKKSRKHAAsDVDLEIESLLNQQSTKEQQS
Q86V48 S996 Sugiyama LUZP1 RRVGPSSGDAPEPSSRRtQssLtVSEVLTRRNRVGDTITVA
Q86V81 S239 Sugiyama ALYREF ALY BEF THOC4 tRGGARGRGRGAGRNSKQQLsAEELDAQLDAyNARMDts__
Q86VQ1 S223 Sugiyama GLCCI1 QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q86YD1 S36 PSP PTOV1 ACID2 PP642 UNQ6127/PRO20092 PLGGRGRPPRPLVVRAVRsRsWPASPRGPQPPRIRARsAPP
Q86YD1 S53 PSP PTOV1 ACID2 PP642 UNQ6127/PRO20092 RsRsWPASPRGPQPPRIRARsAPPMEGARVFGALGPIGPss
Q8IWX8 S904 Sugiyama CHERP DAN26 SCAF6 KGVGVALDDPyENyRRNKsysFIARMKARDECK________
Q8NBJ7 S256 Sugiyama SUMF2 PSEC0171 UNQ1968/PRO4500 EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG
Q8NBJ7 T273 Sugiyama SUMF2 PSEC0171 UNQ1968/PRO4500 RGAsWIDtADGsANHRARVttRMGNtPDsAsDNLGFRCAAD
Q8TD19 S332 Sugiyama NEK9 KIAA1995 NEK8 NERCC RREMEEKVTLLNAPTKRPRsstVtEAPIAVVTSRTSEVYVW
Q8TE77 S37 Sugiyama SSH3 SSH3L tPVGPWDQAVQRRSRLQRRQsFAVLRGAVLGLQDGGDNDDA
Q8WYP5 T1277 Sugiyama AHCTF1 ELYS TMBS62 MSTP108 tPKKCAVPVETEWLKSKDRttsFFLNsPEKEHQEMDEGsQs
Q92597 S330 ELM|Sugiyama NDRG1 CAP43 DRG1 RTP QGMGYMPsAsMtRLMRsRtAsGssVtsLDGtRsRsHtSEGT
Q92597 T328 ELM NDRG1 CAP43 DRG1 RTP FVQGMGYMPsAsMtRLMRsRtAsGssVtsLDGtRsRsHtSE
Q92597 T346 ELM NDRG1 CAP43 DRG1 RTP sRtAsGssVtsLDGtRsRsHtSEGTRsRsHtsEGtRsRsHt
Q92597 T356 ELM NDRG1 CAP43 DRG1 RTP sLDGtRsRsHtSEGTRsRsHtsEGtRsRsHtsEGAHLDItP
Q92597 T375 Sugiyama NDRG1 CAP43 DRG1 RTP HtsEGtRsRsHtsEGAHLDItPNsGAAGNsAGPKSMEVSC_
Q93079 S37 Sugiyama H2BC9 H2BFJ HIST1H2BH KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q93079 S39 Sugiyama H2BC9 H2BFJ HIST1H2BH VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q96G46 S236 Sugiyama DUS3L QQLRKREVRFERAEQALRRFsQGPtPAAAVPEGTAAEGAPR
Q96HE7 S143 Sugiyama ERO1A ERO1L UNQ434/PRO865 EANNLIEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSD
Q96PU5 S342 ELM NEDD4L KIAA0439 NEDL3 NGEQFsSLIQREPssRLRsCsVtDAVAEQGHLPPPSAPAGR
Q96PU5 S448 ELM NEDD4L KIAA0439 NEDL3 sATNSNNHLIEPQIRRPRsLssPtVTLSAPLEGAKDsPVRR
Q96PU5 T367 ELM NEDD4L KIAA0439 NEDL3 VAEQGHLPPPSAPAGRARsstVtGGEEPTPsVAYVHttPGL
Q96RU3 Y500 Sugiyama FNBP1 FBP17 KIAA0554 AEVEGRLPARSEQARRQsGLyDSQNPPTVNNCAQDREsPDG
Q96T58 S1268 Sugiyama SPEN KIAA0929 MINT SHARP SRQISEDsERtGGsPsVRHGsFHEDEDPIGsPRLLSVKGsP
Q99613 S865 Sugiyama EIF3C EIF3S8 HRTEPTAQQNLALQLAEKLGsLVENNERVFDHKQGtyGGyF
Q99759 S166 ELM MAP3K3 MAPKKK3 MEKK3 QsAGDINtIyQPPEPRsRHLsVssQNPGRssPPPGYVPERQ
Q99759 S337 ELM MAP3K3 MAPKKK3 MEKK3 tNGENMGLAVQYLDPRGRLRsADsENALsVQERNVPTKsPs
Q99877 S37 Sugiyama H2BC15 H2BFD HIST1H2BN KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99877 S39 Sugiyama H2BC15 H2BFD HIST1H2BN VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99879 S37 Sugiyama H2BC14 H2BFE HIST1H2BM KAINKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99879 S39 Sugiyama H2BC14 H2BFE HIST1H2BM INKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99880 S37 Sugiyama H2BC13 H2BFC HIST1H2BL KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99880 S39 Sugiyama H2BC13 H2BFC HIST1H2BL VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q9BYX7 S239 Sugiyama POTEKP ACTBL3 FKSG30 VALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPE
Q9C0C2 S429 Sugiyama TNKS1BP1 KIAA1741 TAB182 EEEAKGDAHLRPtsLVQRRFsEGVLQsPsQDQEKLGGsLAA
Q9H0H5 T251 Sugiyama RACGAP1 KIAA1478 MGCRACGAP EAVSTIETVPYWtRSRRKtGtLQPWNsDstLNSRQLEPRTE
Q9H2U1 S167 Sugiyama DHX36 DDX36 KIAA1488 MLEL1 RHAU LINQEKKMFRIRNRsyIDRDsEyLLQENEPDGtLDQKLLED
Q9H3Q1 S311 Sugiyama CDC42EP4 BORG4 CEP4 PsPGsARSMGSHTTRDSSsLssCtsGILEERsPAFRGPDRA
Q9H4A3 T2245 Sugiyama WNK1 HSN2 KDP KIAA0344 PRKWNK1 TVNSQAAQAQPPAMTSSRKGtFtDDLHKLVDNWARDAMNLS
Q9H4A3 T2247 Sugiyama WNK1 HSN2 KDP KIAA0344 PRKWNK1 NSQAAQAQPPAMTSSRKGtFtDDLHKLVDNWARDAMNLSGR
Q9H6H4 S152 Sugiyama REEP4 C8orf20 PP432 AAVQAATKSQGALAGRLRsFsMQDLRSISDAPAPAyHDPLy
Q9H788 S315 Sugiyama SH2D4A PPP1R38 SH2A LNSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRA
Q9HA77 S548 Sugiyama CARS2 OK/SW-cl.10 TLRRGLTAHGINIKDRssttstWELLDQRTKDQKSAG____
Q9NTI5 S1257 Sugiyama PDS5B APRIN AS3 KIAA0979 LVQEQKPKGSQRSRKRGHtAsEsDEQQWPEEKRLKEDILEN
Q9NUU7 T467 Sugiyama DDX19A DDX19L SMNILNRIQEHFNKKIERLDtDDLDEIEKIAN_________
Q9NVR5 S773 Sugiyama DNAAF2 C14orf104 KTU EFIKEKSATCSNEEKDNLNEsVITEEKETDGDHLsSLLNKT
Q9NZN5 S1288 Sugiyama ARHGEF12 KIAA0382 LARG GLTEKsVQEDWQHFPRyRtAsQGPQtDSVIQNSENIKAyHs
Q9NZN5 T1293 Sugiyama ARHGEF12 KIAA0382 LARG sVQEDWQHFPRyRtAsQGPQtDSVIQNSENIKAyHsGEGHM
Q9UBP6 S27 Sugiyama METTL1 C12orf1 NVAGAEAPPPQKRYYRQRAHsNPMADHTLRYPVKPEEMDWS
Q9UGV2 S327 Sugiyama NDRG3 KYFLQGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsV
Q9UGV2 S331 Sugiyama NDRG3 QGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQ
Q9UGV2 T329 Sugiyama NDRG3 FLQGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVts
Q9UGV2 T332 Sugiyama NDRG3 GMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQs
Q9ULL1 T617 Sugiyama PLEKHG1 KIAA1209 ETSSSGHRIVRRAssAGEsNtCPPEIGTSDRTRELQNSPKT
Q9UMR2 T468 Sugiyama DDX19B DBP5 DDX19 TDBP SMNILNRIQEHFNKKIERLDtDDLDEIEKIAN_________
Q9UN36 S332 ELM NDRG2 KIAA1248 SYLD QGMGYMASSCMTRLsRsRtAsLtsAAsVDGNRsRsRtLsQs
Q9UN36 T330 ELM NDRG2 KIAA1248 SYLD FLQGMGYMASSCMTRLsRsRtAsLtsAAsVDGNRsRsRtLs
Q9UN36 T348 ELM NDRG2 KIAA1248 SYLD sRtAsLtsAAsVDGNRsRsRtLsQssEsGtLsSGPPGHTME
Q9UPQ0 S201 Sugiyama LIMCH1 KIAA1102 DCWDsERsDsLsPPRHGRDDsFDsLDsFGsRsRQtPsPDVV
Q9UQ35 S1541 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEsDs
Q9UQ35 S2692 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2I7 S307 Sugiyama PIKFYVE KIAA0981 PIP5K3 TRLVSVQEDAGKsPARNRsAsItNLsLDRsGsPMVPSYEts
Q9Y2V2 S52 ELM CARHSP1 sPLRGNVVPsPLPtRRtRtFsAtVRASQGPVYKGVCKCFCR
Q9Y3S1 T2157 Sugiyama WNK2 KIAA1760 PRKWNK2 SDCCAG43 P/OKcl.13 GPQPALHVQAQVNNSNNKKGtFtDDLHKLVDEWTSKTVGAA
Q9Y3S1 T2159 Sugiyama WNK2 KIAA1760 PRKWNK2 SDCCAG43 P/OKcl.13 QPALHVQAQVNNSNNKKGtFtDDLHKLVDEWTSKTVGAAQL
Q9Y6D5 S277 Sugiyama ARFGEF2 ARFGEP2 BIG2 RSDSGKVSTENGDAPRERGssLsGtDDGAQEVVKDILEDVV
Q9Y6X9 S739 Sugiyama MORC2 KIAA0852 ZCWCC1 VVKKtEsPIKLsPAtPsRKRsVAVsDEEEVEEEAERRKERC
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Cellular response to heat stress R-HSA-3371556 1.887379e-15 14.724 0 0
HSF1-dependent transactivation R-HSA-3371571 5.961898e-14 13.225 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.086908e-13 12.964 0 0
Cell Cycle R-HSA-1640170 7.097656e-13 12.149 0 0
Attenuation phase R-HSA-3371568 2.778666e-12 11.556 0 0
Cell Cycle, Mitotic R-HSA-69278 1.800793e-11 10.745 0 0
Cell Cycle Checkpoints R-HSA-69620 3.488265e-11 10.457 0 0
HSF1 activation R-HSA-3371511 6.728367e-10 9.172 0 0
M Phase R-HSA-68886 2.963576e-09 8.528 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 8.638338e-09 8.064 0 0
G2/M Checkpoints R-HSA-69481 3.850539e-08 7.414 0 0
Cell-Cell communication R-HSA-1500931 4.196850e-08 7.377 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 7.627466e-08 7.118 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.357070e-07 6.867 0 0
Apoptotic execution phase R-HSA-75153 1.471669e-07 6.832 0 0
Cellular Senescence R-HSA-2559583 1.589445e-07 6.799 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.715971e-07 6.566 0 0
Assembly of the pre-replicative complex R-HSA-68867 3.134356e-07 6.504 0 0
Apoptosis R-HSA-109581 5.511195e-07 6.259 0 0
G2/M DNA damage checkpoint R-HSA-69473 6.038869e-07 6.219 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 8.225003e-07 6.085 0 0
Cellular responses to stimuli R-HSA-8953897 7.906100e-07 6.102 0 0
mRNA Splicing - Major Pathway R-HSA-72163 9.212933e-07 6.036 0 0
Cell junction organization R-HSA-446728 1.049326e-06 5.979 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.030248e-06 5.987 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.030248e-06 5.987 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 1.294538e-06 5.888 0 0
Chromatin organization R-HSA-4839726 1.298644e-06 5.887 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.377737e-06 5.861 0 0
Cellular responses to stress R-HSA-2262752 1.544887e-06 5.811 0 0
DNA Double Strand Break Response R-HSA-5693606 1.684506e-06 5.774 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.777728e-06 5.750 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.737034e-06 5.563 0 0
mRNA Splicing R-HSA-72172 3.213989e-06 5.493 0 0
Meiotic synapsis R-HSA-1221632 3.630650e-06 5.440 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 3.806475e-06 5.419 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 4.199476e-06 5.377 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 5.903290e-06 5.229 0 0
DNA Replication Pre-Initiation R-HSA-69002 6.443104e-06 5.191 0 0
Chromatin modifying enzymes R-HSA-3247509 6.525105e-06 5.185 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 7.084714e-06 5.150 0 0
Nucleosome assembly R-HSA-774815 7.969935e-06 5.099 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 7.969935e-06 5.099 0 0
TCF dependent signaling in response to WNT R-HSA-201681 7.946367e-06 5.100 0 0
Processing of DNA double-strand break ends R-HSA-5693607 7.643608e-06 5.117 0 0
Programmed Cell Death R-HSA-5357801 8.040936e-06 5.095 0 0
Intracellular signaling by second messengers R-HSA-9006925 8.395415e-06 5.076 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.022910e-05 4.990 0 0
mRNA 3'-end processing R-HSA-72187 1.063060e-05 4.973 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.100033e-05 4.959 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.281327e-05 4.892 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.325704e-05 4.878 0 0
Adherens junctions interactions R-HSA-418990 1.359610e-05 4.867 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.489879e-05 4.827 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.489879e-05 4.827 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.504185e-05 4.823 0 0
Mitotic Prophase R-HSA-68875 1.514367e-05 4.820 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.593841e-05 4.798 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.617616e-05 4.791 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.778639e-05 4.750 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 2.086882e-05 4.681 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 2.208180e-05 4.656 0 0
S Phase R-HSA-69242 2.188287e-05 4.660 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 2.384767e-05 4.623 0 0
Mitotic Anaphase R-HSA-68882 2.392711e-05 4.621 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 2.629888e-05 4.580 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 2.813344e-05 4.551 0 0
Signal Transduction R-HSA-162582 2.747406e-05 4.561 0 0
Homology Directed Repair R-HSA-5693538 2.975023e-05 4.527 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 3.726563e-05 4.429 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 4.552490e-05 4.342 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 5.162855e-05 4.287 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 4.953038e-05 4.305 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 5.287527e-05 4.277 0 0
Separation of Sister Chromatids R-HSA-2467813 5.533011e-05 4.257 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 5.959333e-05 4.225 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 6.116417e-05 4.214 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 6.252431e-05 4.204 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 6.341794e-05 4.198 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 6.767924e-05 4.170 0 0
HDACs deacetylate histones R-HSA-3214815 6.703174e-05 4.174 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 6.767924e-05 4.170 0 0
HATs acetylate histones R-HSA-3214847 6.992793e-05 4.155 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 7.850156e-05 4.105 0 0
Mitotic Spindle Checkpoint R-HSA-69618 8.006398e-05 4.097 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 7.803445e-05 4.108 0 0
DNA Double-Strand Break Repair R-HSA-5693532 8.741318e-05 4.058 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 9.700290e-05 4.013 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 9.734960e-05 4.012 0 0
Mitotic Prometaphase R-HSA-68877 1.040233e-04 3.983 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 1.049561e-04 3.979 0 0
p75NTR recruits signalling complexes R-HSA-209543 1.097587e-04 3.960 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.191575e-04 3.924 0 0
Meiosis R-HSA-1500620 1.216964e-04 3.915 0 0
Cell-cell junction organization R-HSA-421270 1.219976e-04 3.914 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.409223e-04 3.851 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.481510e-04 3.829 0 0
Gene expression (Transcription) R-HSA-74160 1.495948e-04 3.825 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.563784e-04 3.806 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.583551e-04 3.800 0 0
Metabolism of RNA R-HSA-8953854 1.583574e-04 3.800 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.651358e-04 3.782 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.792281e-04 3.747 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 1.889575e-04 3.724 0 0
DNA Replication R-HSA-69306 1.924744e-04 3.716 0 0
Protein ubiquitination R-HSA-8852135 2.114086e-04 3.675 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.972191e-04 3.705 0 0
ISG15 antiviral mechanism R-HSA-1169408 2.114086e-04 3.675 0 0
Packaging Of Telomere Ends R-HSA-171306 2.193373e-04 3.659 0 0
Gene Silencing by RNA R-HSA-211000 2.212047e-04 3.655 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 2.384801e-04 3.623 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 2.447951e-04 3.611 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.561277e-04 3.592 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 2.784425e-04 3.555 0 0
Regulation of CDH1 Function R-HSA-9764561 2.977982e-04 3.526 0 0
Regulation of PTEN localization R-HSA-8948747 3.039938e-04 3.517 0 0
RNA Polymerase I Transcription R-HSA-73864 3.256264e-04 3.487 0 0
p75NTR signals via NF-kB R-HSA-193639 3.450942e-04 3.462 0 0
Cell-extracellular matrix interactions R-HSA-446353 3.450942e-04 3.462 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 3.450942e-04 3.462 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 3.450942e-04 3.462 0 0
DNA methylation R-HSA-5334118 3.581867e-04 3.446 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 3.869416e-04 3.412 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 3.689058e-04 3.433 0 0
Amplification of signal from the kinetochores R-HSA-141424 3.689058e-04 3.433 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 3.711805e-04 3.430 0 0
NF-kB is activated and signals survival R-HSA-209560 4.388987e-04 3.358 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 4.430304e-04 3.354 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 4.515225e-04 3.345 0 0
Activation of BH3-only proteins R-HSA-114452 4.515225e-04 3.345 0 0
Negative regulation of MET activity R-HSA-6807004 4.649311e-04 3.333 0 0
Epigenetic regulation of gene expression R-HSA-212165 5.189666e-04 3.285 0 0
Regulation of TP53 Degradation R-HSA-6804757 5.615626e-04 3.251 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 5.615626e-04 3.251 0 0
EGFR downregulation R-HSA-182971 5.644023e-04 3.248 0 0
Chromosome Maintenance R-HSA-73886 5.671122e-04 3.246 0 0
HIV Life Cycle R-HSA-162587 5.923276e-04 3.227 0 0
Membrane Trafficking R-HSA-199991 6.330286e-04 3.199 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 6.396432e-04 3.194 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 6.396432e-04 3.194 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 6.839815e-04 3.165 0 0
Cleavage of the damaged purine R-HSA-110331 6.839815e-04 3.165 0 0
Signaling by EGFR R-HSA-177929 7.404104e-04 3.131 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 7.563823e-04 3.121 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 7.563823e-04 3.121 0 0
Defective pyroptosis R-HSA-9710421 7.721962e-04 3.112 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 8.321690e-04 3.080 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 7.968283e-04 3.099 0 0
Depurination R-HSA-73927 8.279856e-04 3.082 0 0
Nuclear Envelope Breakdown R-HSA-2980766 8.627175e-04 3.064 0 0
Signaling by Hippo R-HSA-2028269 8.873206e-04 3.052 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 9.071127e-04 3.042 0 0
SARS-CoV-2-host interactions R-HSA-9705683 9.738283e-04 3.012 0 0
Meiotic recombination R-HSA-912446 9.746003e-04 3.011 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 9.909566e-04 3.004 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 9.964420e-04 3.002 0 0
Switching of origins to a post-replicative state R-HSA-69052 1.129717e-03 2.947 0 0
RNA Polymerase II Transcription R-HSA-73857 1.143407e-03 2.942 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.153972e-03 2.938 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.176132e-03 2.930 0 0
Amyloid fiber formation R-HSA-977225 1.234464e-03 2.909 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.240251e-03 2.906 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.255730e-03 2.901 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 1.419385e-03 2.848 0 0
Late Phase of HIV Life Cycle R-HSA-162599 1.347625e-03 2.870 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.419385e-03 2.848 0 0
Nuclear import of Rev protein R-HSA-180746 1.277442e-03 2.894 0 0
FLT3 Signaling R-HSA-9607240 1.419385e-03 2.848 0 0
Diseases of programmed cell death R-HSA-9645723 1.319783e-03 2.879 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 1.529174e-03 2.816 0 0
Axon guidance R-HSA-422475 1.545528e-03 2.811 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.622553e-03 2.790 0 0
Reproduction R-HSA-1474165 1.640113e-03 2.785 0 0
Signaling by WNT R-HSA-195721 1.690116e-03 2.772 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.761587e-03 2.754 0 0
G2/M Transition R-HSA-69275 1.766248e-03 2.753 0 0
ESR-mediated signaling R-HSA-8939211 1.796846e-03 2.745 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 2.125365e-03 2.673 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 2.032850e-03 2.692 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 2.032850e-03 2.692 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.975317e-03 2.704 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.975317e-03 2.704 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.199182e-03 2.658 0 0
Nephrin family interactions R-HSA-373753 1.965101e-03 2.707 0 0
MTOR signalling R-HSA-165159 1.980601e-03 2.703 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 2.199182e-03 2.658 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.045321e-03 2.689 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 1.980601e-03 2.703 0 0
Depyrimidination R-HSA-73928 1.980601e-03 2.703 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.203203e-03 2.657 0 0
Nervous system development R-HSA-9675108 2.203852e-03 2.657 0 0
Negative regulation of FLT3 R-HSA-9706369 2.260939e-03 2.646 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 2.493406e-03 2.603 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 2.493406e-03 2.603 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 2.493406e-03 2.603 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.605350e-03 2.584 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.605400e-03 2.584 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 2.609235e-03 2.583 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.805016e-03 2.552 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.865874e-03 2.543 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.865874e-03 2.543 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 3.186955e-03 2.497 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 3.186955e-03 2.497 0 0
IRAK1 recruits IKK complex R-HSA-937039 3.280833e-03 2.484 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 3.280833e-03 2.484 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 3.417886e-03 2.466 0 0
snRNP Assembly R-HSA-191859 3.069724e-03 2.513 0 0
Metabolism of non-coding RNA R-HSA-194441 3.069724e-03 2.513 0 0
Signaling by ERBB2 R-HSA-1227986 3.490771e-03 2.457 0 0
Orc1 removal from chromatin R-HSA-68949 3.143307e-03 2.503 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 3.186955e-03 2.497 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 3.070023e-03 2.513 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 3.417886e-03 2.466 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 3.070023e-03 2.513 0 0
Centrosome maturation R-HSA-380287 3.534781e-03 2.452 0 0
Death Receptor Signaling R-HSA-73887 3.571511e-03 2.447 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 3.599064e-03 2.444 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 3.599064e-03 2.444 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 3.648442e-03 2.438 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 3.648442e-03 2.438 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 3.648442e-03 2.438 0 0
Signaling downstream of RAS mutants R-HSA-9649948 3.648442e-03 2.438 0 0
Signaling by RAS mutants R-HSA-6802949 3.648442e-03 2.438 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 3.758543e-03 2.425 0 0
Signaling by NOTCH R-HSA-157118 3.777908e-03 2.423 0 0
PTEN Regulation R-HSA-6807070 3.813798e-03 2.419 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 4.114906e-03 2.386 0 0
Telomere Maintenance R-HSA-157579 4.199828e-03 2.377 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 4.387703e-03 2.358 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 4.585365e-03 2.339 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 5.596875e-03 2.252 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 5.596875e-03 2.252 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 5.596875e-03 2.252 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 5.596875e-03 2.252 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 5.596875e-03 2.252 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 5.596875e-03 2.252 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 5.596875e-03 2.252 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 5.596875e-03 2.252 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 5.596875e-03 2.252 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 5.596875e-03 2.252 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 5.596875e-03 2.252 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 4.773622e-03 2.321 0 0
Signaling by RAF1 mutants R-HSA-9656223 4.875044e-03 2.312 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 4.810550e-03 2.318 0 0
Synthesis of DNA R-HSA-69239 5.495461e-03 2.260 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 5.299063e-03 2.276 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 4.773622e-03 2.321 0 0
Clathrin-mediated endocytosis R-HSA-8856828 5.596316e-03 2.252 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 5.315666e-03 2.274 0 0
Regulation of TP53 Activity R-HSA-5633007 5.534630e-03 2.257 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 5.495461e-03 2.260 0 0
Signaling by ALK in cancer R-HSA-9700206 5.495461e-03 2.260 0 0
Interferon Signaling R-HSA-913531 5.198249e-03 2.284 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 5.634994e-03 2.249 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 5.748060e-03 2.240 0 0
NRIF signals cell death from the nucleus R-HSA-205043 5.748060e-03 2.240 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 5.794124e-03 2.237 0 0
Maturation of protein E R-HSA-9694493 5.864721e-03 2.232 0 0
Maturation of protein E R-HSA-9683683 5.864721e-03 2.232 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 5.913513e-03 2.228 0 0
Regulation of signaling by CBL R-HSA-912631 6.016695e-03 2.221 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 6.372605e-03 2.196 0 0
Josephin domain DUBs R-HSA-5689877 6.372605e-03 2.196 0 0
Pexophagy R-HSA-9664873 6.372605e-03 2.196 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 6.533422e-03 2.185 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 6.662076e-03 2.176 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 6.751474e-03 2.171 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 6.964673e-03 2.157 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 7.392894e-03 2.131 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 7.392894e-03 2.131 0 0
Spry regulation of FGF signaling R-HSA-1295596 7.392894e-03 2.131 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 8.098059e-03 2.092 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 8.130630e-03 2.090 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 8.149049e-03 2.089 0 0
Signaling by EGFR in Cancer R-HSA-1643713 8.356021e-03 2.078 0 0
HIV Infection R-HSA-162906 8.523353e-03 2.069 0 0
Regulation of PTEN gene transcription R-HSA-8943724 8.551688e-03 2.068 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 8.599071e-03 2.066 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 8.599071e-03 2.066 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 8.772949e-03 2.057 0 0
Deubiquitination R-HSA-5688426 8.791436e-03 2.056 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 9.137434e-03 2.039 0 0
Signaling by ROBO receptors R-HSA-376176 9.641213e-03 2.016 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.649099e-03 2.016 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 9.649099e-03 2.016 0 0
Oncogenic MAPK signaling R-HSA-6802957 9.879756e-03 2.005 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 9.879756e-03 2.005 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 9.916842e-03 2.004 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.249005e-02 1.903 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.249005e-02 1.903 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 1.131250e-02 1.946 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 1.099238e-02 1.959 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 1.093229e-02 1.961 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 1.086132e-02 1.964 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.249005e-02 1.903 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 1.165783e-02 1.933 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.146105e-02 1.941 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.176309e-02 1.929 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.189073e-02 1.925 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 1.165783e-02 1.933 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 1.131250e-02 1.946 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.086132e-02 1.964 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.146105e-02 1.941 0 0
NRAGE signals death through JNK R-HSA-193648 1.288578e-02 1.890 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.288578e-02 1.890 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.305108e-02 1.884 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.315793e-02 1.881 0 0
Signaling by MET R-HSA-6806834 1.315793e-02 1.881 0 0
mTORC1-mediated signalling R-HSA-166208 1.317201e-02 1.880 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 1.317201e-02 1.880 0 0
Co-inhibition by PD-1 R-HSA-389948 1.362359e-02 1.866 0 0
Late endosomal microautophagy R-HSA-9615710 1.367339e-02 1.864 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.367339e-02 1.864 0 0
Ub-specific processing proteases R-HSA-5689880 1.374493e-02 1.862 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.379486e-02 1.860 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.379486e-02 1.860 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.379486e-02 1.860 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.379486e-02 1.860 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.379486e-02 1.860 0 0
VLDLR internalisation and degradation R-HSA-8866427 1.455706e-02 1.837 0 0
G1/S Transition R-HSA-69206 1.474222e-02 1.831 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.479766e-02 1.830 0 0
Ca-dependent events R-HSA-111996 1.480124e-02 1.830 0 0
Calmodulin induced events R-HSA-111933 1.552764e-02 1.809 0 0
CaM pathway R-HSA-111997 1.552764e-02 1.809 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 1.660607e-02 1.780 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.660607e-02 1.780 0 0
Base Excision Repair R-HSA-73884 1.674038e-02 1.776 0 0
Type I hemidesmosome assembly R-HSA-446107 1.708541e-02 1.767 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.708541e-02 1.767 0 0
Modulation by Mtb of host immune system R-HSA-9637628 1.708541e-02 1.767 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.732342e-02 1.761 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.765463e-02 1.753 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.771090e-02 1.752 0 0
Degradation of DVL R-HSA-4641258 1.771090e-02 1.752 0 0
HCMV Early Events R-HSA-9609690 1.807171e-02 1.743 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.881803e-02 1.725 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 1.939715e-02 1.712 0 0
Influenza Infection R-HSA-168255 1.943184e-02 1.711 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 2.092120e-02 1.679 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.092120e-02 1.679 0 0
DAG and IP3 signaling R-HSA-1489509 2.110234e-02 1.676 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 2.110234e-02 1.676 0 0
DNA Repair R-HSA-73894 2.145062e-02 1.669 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 2.155162e-02 1.667 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 2.155162e-02 1.667 0 0
Viral Messenger RNA Synthesis R-HSA-168325 2.160642e-02 1.665 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 2.261382e-02 1.646 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.785181e-02 1.555 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.487538e-02 1.604 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.487538e-02 1.604 0 0
Metalloprotease DUBs R-HSA-5689901 2.501362e-02 1.602 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 2.884153e-02 1.540 0 0
Interaction between L1 and Ankyrins R-HSA-445095 2.884153e-02 1.540 0 0
Striated Muscle Contraction R-HSA-390522 2.743890e-02 1.562 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 2.559468e-02 1.592 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 2.358205e-02 1.627 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 2.637933e-02 1.579 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 2.786040e-02 1.555 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 2.279433e-02 1.642 0 0
Translesion synthesis by REV1 R-HSA-110312 2.785181e-02 1.555 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.263247e-02 1.645 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.870118e-02 1.542 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 2.555773e-02 1.592 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 2.785181e-02 1.555 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 2.559468e-02 1.592 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.261382e-02 1.646 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 2.884153e-02 1.540 0 0
Unwinding of DNA R-HSA-176974 2.261382e-02 1.646 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 2.279433e-02 1.642 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 2.387672e-02 1.622 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 2.377702e-02 1.624 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 2.214718e-02 1.655 0 0
Generic Transcription Pathway R-HSA-212436 2.168270e-02 1.664 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.413178e-02 1.617 0 0
Semaphorin interactions R-HSA-373755 2.610371e-02 1.583 0 0
Host Interactions of HIV factors R-HSA-162909 2.332760e-02 1.632 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 2.906609e-02 1.537 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 2.911530e-02 1.536 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 2.911530e-02 1.536 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 2.929887e-02 1.533 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 2.929887e-02 1.533 0 0
Breakdown of the nuclear lamina R-HSA-352238 2.930290e-02 1.533 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 2.940610e-02 1.532 0 0
RAF activation R-HSA-5673000 3.104737e-02 1.508 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 3.104737e-02 1.508 0 0
Activation of HOX genes during differentiation R-HSA-5619507 3.149600e-02 1.502 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 3.149600e-02 1.502 0 0
MAP2K and MAPK activation R-HSA-5674135 3.206269e-02 1.494 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.206269e-02 1.494 0 0
Degradation of CDH1 R-HSA-9766229 3.227433e-02 1.491 0 0
Signaling by FGFR in disease R-HSA-1226099 3.291452e-02 1.483 0 0
Signaling by NOTCH4 R-HSA-9013694 3.291452e-02 1.483 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 3.304672e-02 1.481 0 0
Translesion synthesis by POLI R-HSA-5656121 3.356929e-02 1.474 0 0
Prolonged ERK activation events R-HSA-169893 3.356929e-02 1.474 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 3.356929e-02 1.474 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 3.420946e-02 1.466 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 3.420946e-02 1.466 0 0
Assembly Of The HIV Virion R-HSA-175474 3.420946e-02 1.466 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 3.420946e-02 1.466 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 3.464757e-02 1.460 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 3.464757e-02 1.460 0 0
Oncogene Induced Senescence R-HSA-2559585 3.496787e-02 1.456 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 3.504380e-02 1.455 0 0
SARS-CoV-1-host interactions R-HSA-9692914 3.600203e-02 1.444 0 0
Termination of translesion DNA synthesis R-HSA-5656169 3.764172e-02 1.424 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 3.764172e-02 1.424 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 3.764172e-02 1.424 0 0
Regulation of gene expression in beta cells R-HSA-210745 3.764172e-02 1.424 0 0
FLT3 signaling in disease R-HSA-9682385 3.921009e-02 1.407 0 0
MAPK family signaling cascades R-HSA-5683057 3.950035e-02 1.403 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 3.996521e-02 1.398 0 0
Translesion synthesis by POLK R-HSA-5655862 3.996521e-02 1.398 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 3.996521e-02 1.398 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 3.996521e-02 1.398 0 0
Vesicle-mediated transport R-HSA-5653656 4.368158e-02 1.360 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 4.378264e-02 1.359 0 0
G alpha (12/13) signalling events R-HSA-416482 4.494266e-02 1.347 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 4.512650e-02 1.346 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 4.554869e-02 1.342 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 4.558179e-02 1.341 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 4.630558e-02 1.334 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 4.705226e-02 1.327 0 0
Glycogen storage diseases R-HSA-3229121 4.705226e-02 1.327 0 0
Regulation of PTEN stability and activity R-HSA-8948751 4.705731e-02 1.327 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 4.804285e-02 1.318 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 4.804285e-02 1.318 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 4.822001e-02 1.317 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 4.822001e-02 1.317 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 4.822001e-02 1.317 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 4.938972e-02 1.306 0 0
tRNA processing in the nucleus R-HSA-6784531 4.938972e-02 1.306 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 7.264528e-02 1.139 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 7.264528e-02 1.139 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 5.964168e-02 1.224 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 5.964168e-02 1.224 0 0
Formation of annular gap junctions R-HSA-196025 7.456155e-02 1.127 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 7.456155e-02 1.127 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 7.456155e-02 1.127 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 5.464738e-02 1.262 0 0
Repression of WNT target genes R-HSA-4641265 5.464738e-02 1.262 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 6.516566e-02 1.186 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 5.483741e-02 1.261 0 0
Dual Incision in GG-NER R-HSA-5696400 7.388074e-02 1.131 0 0
Aggrephagy R-HSA-9646399 5.955141e-02 1.225 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 5.955141e-02 1.225 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 6.801042e-02 1.167 0 0
Eukaryotic Translation Initiation R-HSA-72613 7.322909e-02 1.135 0 0
Cap-dependent Translation Initiation R-HSA-72737 7.322909e-02 1.135 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 6.823427e-02 1.166 0 0
DNA Damage Bypass R-HSA-73893 6.901276e-02 1.161 0 0
Translesion Synthesis by POLH R-HSA-110320 6.332205e-02 1.198 0 0
DNA strand elongation R-HSA-69190 5.386540e-02 1.269 0 0
Frs2-mediated activation R-HSA-170968 6.516566e-02 1.186 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 7.182114e-02 1.144 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 6.346719e-02 1.197 0 0
Diseases of mitotic cell cycle R-HSA-9675126 5.386540e-02 1.269 0 0
Myogenesis R-HSA-525793 6.648693e-02 1.177 0 0
Rap1 signalling R-HSA-392517 6.332205e-02 1.198 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 6.648693e-02 1.177 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 6.550840e-02 1.184 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 7.235683e-02 1.141 0 0
Response of endothelial cells to shear stress R-HSA-9860931 5.263504e-02 1.279 0 0
Stabilization of p53 R-HSA-69541 5.394758e-02 1.268 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 7.182114e-02 1.144 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 7.182114e-02 1.144 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 5.394758e-02 1.268 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 7.388074e-02 1.131 0 0
Signaling by FGFR2 R-HSA-5654738 5.198059e-02 1.284 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 5.876068e-02 1.231 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 5.199828e-02 1.284 0 0
Neurodegenerative Diseases R-HSA-8863678 5.199828e-02 1.284 0 0
Glycogen synthesis R-HSA-3322077 7.250224e-02 1.140 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 6.011050e-02 1.221 0 0
FGFR1 mutant receptor activation R-HSA-1839124 6.011050e-02 1.221 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 7.452869e-02 1.128 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 5.394758e-02 1.268 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 6.482052e-02 1.188 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 5.978855e-02 1.223 0 0
NOD1/2 Signaling Pathway R-HSA-168638 7.388074e-02 1.131 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 5.352610e-02 1.271 0 0
Signaling by PTK6 R-HSA-8848021 5.352610e-02 1.271 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 6.648693e-02 1.177 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 5.964168e-02 1.224 0 0
Vpu mediated degradation of CD4 R-HSA-180534 6.678172e-02 1.175 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 7.388074e-02 1.131 0 0
HCMV Late Events R-HSA-9610379 6.531823e-02 1.185 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 5.464738e-02 1.262 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 5.464738e-02 1.262 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 5.483741e-02 1.261 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 6.516566e-02 1.186 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 6.901276e-02 1.161 0 0
Glycolysis R-HSA-70171 7.154768e-02 1.145 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 5.483741e-02 1.261 0 0
Regulation of RAS by GAPs R-HSA-5658442 7.496620e-02 1.125 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 7.552346e-02 1.122 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 7.552346e-02 1.122 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 7.552346e-02 1.122 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 7.704375e-02 1.113 0 0
Rab regulation of trafficking R-HSA-9007101 7.718667e-02 1.112 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 8.061432e-02 1.094 0 0
SARS-CoV-2 Infection R-HSA-9694516 8.130300e-02 1.090 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 8.140737e-02 1.089 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 8.140737e-02 1.089 0 0
Regulation of Apoptosis R-HSA-169911 8.140737e-02 1.089 0 0
PCP/CE pathway R-HSA-4086400 8.303090e-02 1.081 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 8.309893e-02 1.080 0 0
Formation of the Early Elongation Complex R-HSA-113418 8.309893e-02 1.080 0 0
HIV elongation arrest and recovery R-HSA-167287 8.309893e-02 1.080 0 0
Pausing and recovery of HIV elongation R-HSA-167290 8.309893e-02 1.080 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 8.309893e-02 1.080 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 8.429485e-02 1.074 0 0
PDGFR mutants bind TKIs R-HSA-9674428 8.429485e-02 1.074 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 8.429485e-02 1.074 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 8.429485e-02 1.074 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 8.429485e-02 1.074 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 8.429485e-02 1.074 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 8.429485e-02 1.074 0 0
Signaling by FGFR4 R-HSA-5654743 8.551797e-02 1.068 0 0
TBC/RABGAPs R-HSA-8854214 8.551797e-02 1.068 0 0
Cytokine Signaling in Immune system R-HSA-1280215 8.583329e-02 1.066 0 0
PLC beta mediated events R-HSA-112043 8.880726e-02 1.052 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 8.894303e-02 1.051 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 8.935958e-02 1.049 0 0
ARMS-mediated activation R-HSA-170984 9.095205e-02 1.041 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 9.095205e-02 1.041 0 0
WNT mediated activation of DVL R-HSA-201688 9.095205e-02 1.041 0 0
Gap junction degradation R-HSA-190873 9.095205e-02 1.041 0 0
GP1b-IX-V activation signalling R-HSA-430116 9.095205e-02 1.041 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.124242e-02 1.040 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.219174e-02 1.035 0 0
Signaling by PDGFR in disease R-HSA-9671555 9.290848e-02 1.032 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 9.290848e-02 1.032 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 9.290848e-02 1.032 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 9.408722e-02 1.026 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 9.441114e-02 1.025 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 9.494682e-02 1.023 0 0
Regulation of mitotic cell cycle R-HSA-453276 9.494682e-02 1.023 0 0
Developmental Biology R-HSA-1266738 9.565889e-02 1.019 0 0
Autophagy R-HSA-9612973 9.598900e-02 1.018 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.628214e-02 1.016 0 0
Degradation of AXIN R-HSA-4641257 9.773354e-02 1.010 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 9.889227e-02 1.005 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 9.889227e-02 1.005 0 0
Signaling by FGFR3 R-HSA-5654741 1.006373e-01 0.997 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.017985e-01 0.992 0 0
Activation of the pre-replicative complex R-HSA-68962 1.017985e-01 0.992 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 1.019015e-01 0.992 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.019015e-01 0.992 0 0
Phosphorylation of the APC/C R-HSA-176412 1.024294e-01 0.990 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.024294e-01 0.990 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 1.024294e-01 0.990 0 0
Regulation of BACH1 activity R-HSA-9708530 1.024294e-01 0.990 0 0
FGFR2 alternative splicing R-HSA-6803529 1.041026e-01 0.983 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 1.041026e-01 0.983 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 1.069288e-01 0.971 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.086869e-01 0.964 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.087236e-01 0.964 0 0
Signaling by NOTCH3 R-HSA-9012852 1.093152e-01 0.961 0 0
Circadian clock R-HSA-9909396 1.103190e-01 0.957 0 0
Macroautophagy R-HSA-1632852 1.115140e-01 0.953 0 0
Budding and maturation of HIV virion R-HSA-162588 1.119080e-01 0.951 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.139988e-01 0.943 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.155261e-01 0.937 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.155261e-01 0.937 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 1.157226e-01 0.937 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.160560e-01 0.935 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 1.166203e-01 0.933 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 1.166203e-01 0.933 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 1.170909e-01 0.931 0 0
TNF signaling R-HSA-75893 1.170909e-01 0.931 0 0
Cilium Assembly R-HSA-5617833 1.183436e-01 0.927 0 0
Hedgehog 'off' state R-HSA-5610787 1.188948e-01 0.925 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.196224e-01 0.922 0 0
HCMV Infection R-HSA-9609646 1.202813e-01 0.920 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.206525e-01 0.918 0 0
G0 and Early G1 R-HSA-1538133 1.225066e-01 0.912 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.225066e-01 0.912 0 0
Glucose metabolism R-HSA-70326 1.230602e-01 0.910 0 0
Interleukin-1 signaling R-HSA-9020702 1.249538e-01 0.903 0 0
HIV Transcription Elongation R-HSA-167169 1.253215e-01 0.902 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 1.253215e-01 0.902 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 1.253215e-01 0.902 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.254505e-01 0.902 0 0
IRS activation R-HSA-74713 1.273052e-01 0.895 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.273052e-01 0.895 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 1.273052e-01 0.895 0 0
Signaling by APC mutants R-HSA-4839744 1.276316e-01 0.894 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.276316e-01 0.894 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.276316e-01 0.894 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.276316e-01 0.894 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 1.283626e-01 0.892 0 0
UCH proteinases R-HSA-5689603 1.285001e-01 0.891 0 0
Signaling by NOTCH1 R-HSA-1980143 1.285001e-01 0.891 0 0
G-protein mediated events R-HSA-112040 1.312505e-01 0.882 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.316129e-01 0.881 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.316129e-01 0.881 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 1.316129e-01 0.881 0 0
Specification of primordial germ cells R-HSA-9827857 1.316129e-01 0.881 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.614887e-01 0.792 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 1.614887e-01 0.792 0 0
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) R-HSA-5619043 1.614887e-01 0.792 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.614887e-01 0.792 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 1.614887e-01 0.792 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 2.321793e-01 0.634 0 0
IKBKB deficiency causes SCID R-HSA-5602636 2.321793e-01 0.634 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.321793e-01 0.634 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 2.321793e-01 0.634 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.321793e-01 0.634 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 2.321793e-01 0.634 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 2.321793e-01 0.634 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 1.573330e-01 0.803 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.573330e-01 0.803 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 1.573330e-01 0.803 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 1.885019e-01 0.725 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.476471e-01 0.831 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 2.204067e-01 0.657 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 2.204067e-01 0.657 0 0
SOS-mediated signalling R-HSA-112412 2.204067e-01 0.657 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.685931e-01 0.773 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.685931e-01 0.773 0 0
Scavenging by Class F Receptors R-HSA-3000484 1.685931e-01 0.773 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.685931e-01 0.773 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.685931e-01 0.773 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.685931e-01 0.773 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.685931e-01 0.773 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 2.527022e-01 0.597 0 0
PKA activation R-HSA-163615 1.473499e-01 0.832 0 0
PKA activation in glucagon signalling R-HSA-164378 1.473499e-01 0.832 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 2.127246e-01 0.672 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 1.808113e-01 0.743 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.356436e-01 0.628 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.690011e-01 0.772 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.690011e-01 0.772 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.690011e-01 0.772 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.451058e-01 0.838 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 2.589633e-01 0.587 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 2.164935e-01 0.665 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 2.164935e-01 0.665 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 1.835472e-01 0.736 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.985320e-01 0.702 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.564068e-01 0.806 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 2.139170e-01 0.670 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.335202e-01 0.874 0 0
Translation initiation complex formation R-HSA-72649 1.851924e-01 0.732 0 0
Recycling pathway of L1 R-HSA-437239 2.149866e-01 0.668 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 2.149866e-01 0.668 0 0
Dual incision in TC-NER R-HSA-6782135 2.302210e-01 0.638 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.392952e-01 0.856 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.392952e-01 0.856 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 2.313936e-01 0.636 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 2.424006e-01 0.615 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 2.209133e-01 0.656 0 0
Peptide chain elongation R-HSA-156902 2.407603e-01 0.618 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.651306e-01 0.782 0 0
Nucleotide Excision Repair R-HSA-5696398 1.578182e-01 0.802 0 0
Signaling by NOTCH2 R-HSA-1980145 1.570688e-01 0.804 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 1.353099e-01 0.869 0 0
EPH-Ephrin signaling R-HSA-2682334 1.946213e-01 0.711 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 2.164935e-01 0.665 0 0
TGFBR3 expression R-HSA-9839394 1.413739e-01 0.850 0 0
FOXO-mediated transcription R-HSA-9614085 1.789867e-01 0.747 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.906362e-01 0.720 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 1.353099e-01 0.869 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 2.139170e-01 0.670 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 2.341875e-01 0.630 0 0
DCC mediated attractive signaling R-HSA-418885 2.356436e-01 0.628 0 0
G1 Phase R-HSA-69236 1.789028e-01 0.747 0 0
Cyclin D associated events in G1 R-HSA-69231 1.789028e-01 0.747 0 0
ER-Phagosome pathway R-HSA-1236974 2.506416e-01 0.601 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.789028e-01 0.747 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.808113e-01 0.743 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 1.642362e-01 0.785 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.946213e-01 0.711 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.565568e-01 0.805 0 0
Long-term potentiation R-HSA-9620244 1.413739e-01 0.850 0 0
Integrin signaling R-HSA-354192 2.620765e-01 0.582 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 2.527022e-01 0.597 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.694462e-01 0.771 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 2.477979e-01 0.606 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.573330e-01 0.803 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.356436e-01 0.628 0 0
Degradation of CRY and PER proteins R-HSA-9932298 1.456761e-01 0.837 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 1.564068e-01 0.806 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 2.139170e-01 0.670 0 0
Fanconi Anemia Pathway R-HSA-6783310 1.906362e-01 0.720 0 0
Nuclear RNA decay R-HSA-9930044 2.620765e-01 0.582 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 2.149866e-01 0.668 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.985320e-01 0.702 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 1.335785e-01 0.874 0 0
Selective autophagy R-HSA-9663891 1.542694e-01 0.812 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 1.363510e-01 0.865 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 1.456341e-01 0.837 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.808113e-01 0.743 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 1.984075e-01 0.702 0 0
Ovarian tumor domain proteases R-HSA-5689896 1.953511e-01 0.709 0 0
Kinesins R-HSA-983189 1.510828e-01 0.821 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 2.330359e-01 0.633 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 1.690011e-01 0.772 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 2.149866e-01 0.668 0 0
Interleukin-1 family signaling R-HSA-446652 2.476824e-01 0.606 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 2.296628e-01 0.639 0 0
Post NMDA receptor activation events R-HSA-438064 1.467643e-01 0.833 0 0
Signaling by FGFR R-HSA-190236 1.712730e-01 0.766 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.594427e-01 0.797 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 2.321793e-01 0.634 0 0
Signaling by AXIN mutants R-HSA-4839735 1.476471e-01 0.831 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.476471e-01 0.831 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 1.637704e-01 0.786 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 2.356436e-01 0.628 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.335785e-01 0.874 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 1.541921e-01 0.812 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 2.535848e-01 0.596 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.394856e-01 0.855 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.413739e-01 0.850 0 0
Signaling by FGFR1 R-HSA-5654736 2.072234e-01 0.684 0 0
Platelet degranulation R-HSA-114608 1.934179e-01 0.714 0 0
Adaptive Immune System R-HSA-1280218 2.087558e-01 0.680 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.725195e-01 0.763 0 0
Regulation of necroptotic cell death R-HSA-5675482 2.620765e-01 0.582 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 1.350267e-01 0.870 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 1.350267e-01 0.870 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 2.392109e-01 0.621 0 0
Signaling by VEGF R-HSA-194138 2.577461e-01 0.589 0 0
Mitophagy R-HSA-5205647 1.570688e-01 0.804 0 0
Muscle contraction R-HSA-397014 2.407962e-01 0.618 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 1.906362e-01 0.720 0 0
Signaling by TGFB family members R-HSA-9006936 1.644857e-01 0.784 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 2.463770e-01 0.608 0 0
Interferon gamma signaling R-HSA-877300 1.587706e-01 0.799 0 0
Glycogen metabolism R-HSA-8982491 2.367076e-01 0.626 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.573330e-01 0.803 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 1.903308e-01 0.720 0 0
Protein methylation R-HSA-8876725 2.356436e-01 0.628 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 1.353099e-01 0.869 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 2.296628e-01 0.639 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 2.662728e-01 0.575 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 1.674875e-01 0.776 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 1.789028e-01 0.747 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.510828e-01 0.821 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.510828e-01 0.821 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.510828e-01 0.821 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.510828e-01 0.821 0 0
PI Metabolism R-HSA-1483255 2.031033e-01 0.692 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.510828e-01 0.821 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 1.573330e-01 0.803 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 2.204067e-01 0.657 0 0
Adrenoceptors R-HSA-390696 2.527022e-01 0.597 0 0
Sodium/Proton exchangers R-HSA-425986 2.527022e-01 0.597 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 2.226238e-01 0.652 0 0
PKR-mediated signaling R-HSA-9833482 1.594427e-01 0.797 0 0
MAP kinase activation R-HSA-450294 2.662728e-01 0.575 0 0
Viral Infection Pathways R-HSA-9824446 2.203903e-01 0.657 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 1.353099e-01 0.869 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 1.906362e-01 0.720 0 0
Activation of ATR in response to replication stress R-HSA-176187 2.620765e-01 0.582 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 2.016675e-01 0.695 0 0
Inositol phosphate metabolism R-HSA-1483249 1.392952e-01 0.856 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.779337e-01 0.750 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 2.356436e-01 0.628 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.697230e-01 0.770 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 1.984075e-01 0.702 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 1.984075e-01 0.702 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 2.412052e-01 0.618 0 0
Interleukin-12 signaling R-HSA-9020591 2.114454e-01 0.675 0 0
Plasma lipoprotein clearance R-HSA-8964043 2.226238e-01 0.652 0 0
Translation of Structural Proteins R-HSA-9683701 2.656344e-01 0.576 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 2.666906e-01 0.574 0 0
Hedgehog ligand biogenesis R-HSA-5358346 2.666906e-01 0.574 0 0
SARS-CoV-1 Infection R-HSA-9678108 2.695290e-01 0.569 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.730355e-01 0.564 0 0
Deadenylation of mRNA R-HSA-429947 2.730355e-01 0.564 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 2.764356e-01 0.558 0 0
Heme signaling R-HSA-9707616 2.786431e-01 0.555 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.825658e-01 0.549 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 2.825658e-01 0.549 0 0
TCR signaling R-HSA-202403 2.830354e-01 0.548 0 0
Lipophagy R-HSA-9613354 2.850959e-01 0.545 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 2.850959e-01 0.545 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 2.850959e-01 0.545 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 2.850959e-01 0.545 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 2.850959e-01 0.545 0 0
SARS-CoV Infections R-HSA-9679506 2.891315e-01 0.539 0 0
Developmental Cell Lineages R-HSA-9734767 2.928961e-01 0.533 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 2.937248e-01 0.532 0 0
Smooth Muscle Contraction R-HSA-445355 2.937248e-01 0.532 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 2.953888e-01 0.530 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 2.954529e-01 0.530 0 0
eNOS activation R-HSA-203615 2.954529e-01 0.530 0 0
Calnexin/calreticulin cycle R-HSA-901042 2.954529e-01 0.530 0 0
Ribosome-associated quality control R-HSA-9948299 2.957753e-01 0.529 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 2.969141e-01 0.527 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 2.969141e-01 0.527 0 0
Potassium transport channels R-HSA-1296067 2.969141e-01 0.527 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 2.969141e-01 0.527 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 2.969141e-01 0.527 0 0
Interleukin-33 signaling R-HSA-9014843 2.969141e-01 0.527 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 2.969141e-01 0.527 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 2.969141e-01 0.527 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.971965e-01 0.527 0 0
Signaling by ERBB4 R-HSA-1236394 2.998447e-01 0.523 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 3.038178e-01 0.517 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 3.063408e-01 0.514 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 3.063408e-01 0.514 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 3.063408e-01 0.514 0 0
Organelle biogenesis and maintenance R-HSA-1852241 3.100451e-01 0.509 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 3.117263e-01 0.506 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 3.119981e-01 0.506 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 3.119981e-01 0.506 0 0
Suppression of phagosomal maturation R-HSA-9637687 3.119981e-01 0.506 0 0
Signalling to ERKs R-HSA-187687 3.124035e-01 0.505 0 0
Folding of actin by CCT/TriC R-HSA-390450 3.173419e-01 0.498 0 0
Regulation of CDH11 function R-HSA-9762292 3.173419e-01 0.498 0 0
PI3K/AKT activation R-HSA-198203 3.173419e-01 0.498 0 0
Signal attenuation R-HSA-74749 3.173419e-01 0.498 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 3.173419e-01 0.498 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 3.173419e-01 0.498 0 0
Signaling by Leptin R-HSA-2586552 3.173419e-01 0.498 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 3.173586e-01 0.498 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 3.180730e-01 0.497 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 3.293950e-01 0.482 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 3.293950e-01 0.482 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 3.294778e-01 0.482 0 0
RNA Polymerase III Transcription R-HSA-74158 3.294778e-01 0.482 0 0
RET signaling R-HSA-8853659 3.294778e-01 0.482 0 0
G1/S-Specific Transcription R-HSA-69205 3.294778e-01 0.482 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 3.301860e-01 0.481 0 0
GAB1 signalosome R-HSA-180292 3.301860e-01 0.481 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 3.301860e-01 0.481 0 0
Synaptic adhesion-like molecules R-HSA-8849932 3.301860e-01 0.481 0 0
Polo-like kinase mediated events R-HSA-156711 3.301860e-01 0.481 0 0
Mismatch Repair R-HSA-5358508 3.301860e-01 0.481 0 0
Platelet sensitization by LDL R-HSA-432142 3.301860e-01 0.481 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 3.301860e-01 0.481 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 3.316787e-01 0.479 0 0
Formation of a pool of free 40S subunits R-HSA-72689 3.340200e-01 0.476 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 3.352916e-01 0.475 0 0
Interleukin-12 family signaling R-HSA-447115 3.407941e-01 0.468 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 3.410901e-01 0.467 0 0
Signaling by TGFBR3 R-HSA-9839373 3.410901e-01 0.467 0 0
Neutrophil degranulation R-HSA-6798695 3.453974e-01 0.462 0 0
PECAM1 interactions R-HSA-210990 3.492353e-01 0.457 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 3.492353e-01 0.457 0 0
Bicarbonate transporters R-HSA-425381 3.492353e-01 0.457 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 3.492353e-01 0.457 0 0
Interleukin-2 signaling R-HSA-9020558 3.492353e-01 0.457 0 0
ChREBP activates metabolic gene expression R-HSA-163765 3.492353e-01 0.457 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 3.492353e-01 0.457 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 3.540071e-01 0.451 0 0
STING mediated induction of host immune responses R-HSA-1834941 3.540071e-01 0.451 0 0
Signaling by Interleukins R-HSA-449147 3.549912e-01 0.450 0 0
Transcription of the HIV genome R-HSA-167172 3.554528e-01 0.449 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 3.561947e-01 0.448 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 3.561947e-01 0.448 0 0
MET activates PTPN11 R-HSA-8865999 3.561947e-01 0.448 0 0
MET interacts with TNS proteins R-HSA-8875513 3.561947e-01 0.448 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 3.561947e-01 0.448 0 0
L1CAM interactions R-HSA-373760 3.608721e-01 0.443 0 0
MET promotes cell motility R-HSA-8875878 3.638495e-01 0.439 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 3.638495e-01 0.439 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 3.638495e-01 0.439 0 0
mRNA Capping R-HSA-72086 3.711604e-01 0.430 0 0
DARPP-32 events R-HSA-180024 3.711604e-01 0.430 0 0
Co-stimulation by CD28 R-HSA-389356 3.719576e-01 0.430 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 3.719576e-01 0.430 0 0
Downstream TCR signaling R-HSA-202424 3.753452e-01 0.426 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 3.772087e-01 0.423 0 0
rRNA processing R-HSA-72312 3.775650e-01 0.423 0 0
Regulation of beta-cell development R-HSA-186712 3.775887e-01 0.423 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 3.806062e-01 0.420 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 3.806062e-01 0.420 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 3.806062e-01 0.420 0 0
Interleukin-17 signaling R-HSA-448424 3.816576e-01 0.418 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 3.829138e-01 0.417 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 3.869444e-01 0.412 0 0
Interleukin-37 signaling R-HSA-9008059 3.908588e-01 0.408 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 3.909673e-01 0.408 0 0
Hedgehog 'on' state R-HSA-5632684 3.948023e-01 0.404 0 0
Interleukin-2 family signaling R-HSA-451927 3.982847e-01 0.400 0 0
Lagging Strand Synthesis R-HSA-69186 4.012399e-01 0.397 0 0
Early Phase of HIV Life Cycle R-HSA-162594 4.012399e-01 0.397 0 0
Basigin interactions R-HSA-210991 4.012399e-01 0.397 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 4.012399e-01 0.397 0 0
PI3K Cascade R-HSA-109704 4.029061e-01 0.395 0 0
Signaling by FGFR2 in disease R-HSA-5655253 4.029061e-01 0.395 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 4.059303e-01 0.392 0 0
Trafficking of AMPA receptors R-HSA-399719 4.104657e-01 0.387 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 4.104803e-01 0.387 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 4.104803e-01 0.387 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.104803e-01 0.387 0 0
Regulation of gap junction activity R-HSA-191650 4.104803e-01 0.387 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 4.104803e-01 0.387 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 4.104803e-01 0.387 0 0
NADE modulates death signalling R-HSA-205025 4.104803e-01 0.387 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 4.104803e-01 0.387 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 4.113163e-01 0.386 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 4.113163e-01 0.386 0 0
Leading Strand Synthesis R-HSA-69109 4.113163e-01 0.386 0 0
Polymerase switching R-HSA-69091 4.113163e-01 0.386 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 4.113163e-01 0.386 0 0
OAS antiviral response R-HSA-8983711 4.113163e-01 0.386 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 4.154438e-01 0.381 0 0
Viral mRNA Translation R-HSA-192823 4.218093e-01 0.375 0 0
Immune System R-HSA-168256 4.260348e-01 0.371 0 0
Signaling by WNT in cancer R-HSA-4791275 4.299374e-01 0.367 0 0
MHC class II antigen presentation R-HSA-2132295 4.313803e-01 0.365 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 4.325229e-01 0.364 0 0
Opioid Signalling R-HSA-111885 4.328619e-01 0.364 0 0
Neurexins and neuroligins R-HSA-6794361 4.337449e-01 0.363 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 4.337449e-01 0.363 0 0
Formation of axial mesoderm R-HSA-9796292 4.412540e-01 0.355 0 0
Maturation of nucleoprotein R-HSA-9683610 4.412540e-01 0.355 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 4.412540e-01 0.355 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 4.462345e-01 0.350 0 0
Notch-HLH transcription pathway R-HSA-350054 4.474446e-01 0.349 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 4.474446e-01 0.349 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 4.474446e-01 0.349 0 0
IGF1R signaling cascade R-HSA-2428924 4.482896e-01 0.348 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 4.492334e-01 0.348 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 4.492334e-01 0.348 0 0
G-protein beta:gamma signalling R-HSA-397795 4.492334e-01 0.348 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 4.492334e-01 0.348 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 4.492334e-01 0.348 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 4.492334e-01 0.348 0 0
Eukaryotic Translation Termination R-HSA-72764 4.566745e-01 0.340 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 4.601915e-01 0.337 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 4.601915e-01 0.337 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 4.601915e-01 0.337 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 4.601915e-01 0.337 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 4.601915e-01 0.337 0 0
Activation of AKT2 R-HSA-165158 4.601915e-01 0.337 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 4.601915e-01 0.337 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 4.601915e-01 0.337 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 4.601915e-01 0.337 0 0
Reelin signalling pathway R-HSA-8866376 4.601915e-01 0.337 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 4.601915e-01 0.337 0 0
Interleukin-36 pathway R-HSA-9014826 4.601915e-01 0.337 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 4.601915e-01 0.337 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 4.623000e-01 0.335 0 0
Cellular response to hypoxia R-HSA-1234174 4.623000e-01 0.335 0 0
Response of Mtb to phagocytosis R-HSA-9637690 4.663285e-01 0.331 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 4.682261e-01 0.330 0 0
Resolution of D-Loop Structures R-HSA-5693537 4.683167e-01 0.329 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 4.683167e-01 0.329 0 0
Interleukin receptor SHC signaling R-HSA-912526 4.700089e-01 0.328 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 4.700089e-01 0.328 0 0
Syndecan interactions R-HSA-3000170 4.700089e-01 0.328 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 4.703313e-01 0.328 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 4.703313e-01 0.328 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 4.703313e-01 0.328 0 0
CRMPs in Sema3A signaling R-HSA-399956 4.703313e-01 0.328 0 0
Signaling by FGFR4 in disease R-HSA-5655291 4.703313e-01 0.328 0 0
Regulation of KIT signaling R-HSA-1433559 4.703313e-01 0.328 0 0
Signal regulatory protein family interactions R-HSA-391160 4.703313e-01 0.328 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 4.768742e-01 0.322 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 4.871531e-01 0.312 0 0
Antigen processing-Cross presentation R-HSA-1236975 4.877878e-01 0.312 0 0
Stimuli-sensing channels R-HSA-2672351 4.877878e-01 0.312 1 1
Signaling by NTRK1 (TRKA) R-HSA-187037 4.917532e-01 0.308 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 4.921475e-01 0.308 0 0
Ion homeostasis R-HSA-5578775 4.944033e-01 0.306 0 0
Signaling by NTRKs R-HSA-166520 4.950723e-01 0.305 0 0
Signaling by Hedgehog R-HSA-5358351 4.982729e-01 0.303 0 0
Erythropoietin activates RAS R-HSA-9027284 4.984804e-01 0.302 0 0
Processive synthesis on the lagging strand R-HSA-69183 4.984804e-01 0.302 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 4.984804e-01 0.302 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 4.984804e-01 0.302 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 4.994932e-01 0.301 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 4.994932e-01 0.301 0 0
Regulated Necrosis R-HSA-5218859 5.037833e-01 0.298 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.057135e-01 0.296 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.057135e-01 0.296 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 5.057135e-01 0.296 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 5.057135e-01 0.296 0 0
Signaling by RNF43 mutants R-HSA-5340588 5.057135e-01 0.296 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.057135e-01 0.296 0 0
PDE3B signalling R-HSA-165160 5.057135e-01 0.296 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 5.057135e-01 0.296 0 0
PKB-mediated events R-HSA-109703 5.057135e-01 0.296 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.057135e-01 0.296 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.057135e-01 0.296 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 5.057135e-01 0.296 0 0
IRS-mediated signalling R-HSA-112399 5.092434e-01 0.293 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 5.092434e-01 0.293 0 0
HDMs demethylate histones R-HSA-3214842 5.138184e-01 0.289 0 0
ABC-family proteins mediated transport R-HSA-382556 5.138955e-01 0.289 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 5.157777e-01 0.288 0 0
Regulation of pyruvate metabolism R-HSA-9861718 5.157777e-01 0.288 0 0
Platelet activation, signaling and aggregation R-HSA-76002 5.180593e-01 0.286 0 0
FGFR2 mutant receptor activation R-HSA-1839126 5.239649e-01 0.281 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 5.251367e-01 0.280 0 0
Selenocysteine synthesis R-HSA-2408557 5.251367e-01 0.280 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 5.256512e-01 0.279 0 0
Killing mechanisms R-HSA-9664420 5.256512e-01 0.279 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 5.256512e-01 0.279 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 5.256512e-01 0.279 0 0
Differentiation of T cells R-HSA-9945266 5.256512e-01 0.279 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 5.256512e-01 0.279 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 5.256512e-01 0.279 0 0
Adipogenesis R-HSA-9843745 5.312641e-01 0.275 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 5.349857e-01 0.272 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 5.349857e-01 0.272 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 5.349857e-01 0.272 0 0
Peroxisomal protein import R-HSA-9033241 5.384163e-01 0.269 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 5.409982e-01 0.267 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 5.473992e-01 0.262 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 5.473992e-01 0.262 0 0
Signaling by LTK in cancer R-HSA-9842640 5.473992e-01 0.262 0 0
Erythropoietin activates STAT5 R-HSA-9027283 5.473992e-01 0.262 0 0
STAT5 Activation R-HSA-9645135 5.473992e-01 0.262 0 0
Autointegration results in viral DNA circles R-HSA-177539 5.473992e-01 0.262 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 5.473992e-01 0.262 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 5.473992e-01 0.262 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 5.473992e-01 0.262 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 5.473992e-01 0.262 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 5.473992e-01 0.262 0 0
Lactose synthesis R-HSA-5653890 5.473992e-01 0.262 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 5.473992e-01 0.262 0 0
Nef and signal transduction R-HSA-164944 5.473992e-01 0.262 0 0
NGF-stimulated transcription R-HSA-9031628 5.476510e-01 0.261 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 5.518086e-01 0.258 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 5.518086e-01 0.258 0 0
Coenzyme A biosynthesis R-HSA-196783 5.518086e-01 0.258 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 5.527198e-01 0.257 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 5.556195e-01 0.255 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 5.556195e-01 0.255 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 5.556195e-01 0.255 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 5.594579e-01 0.252 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 5.632049e-01 0.249 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 5.654659e-01 0.248 0 0
RSV-host interactions R-HSA-9833110 5.691692e-01 0.245 0 0
Ca2+ pathway R-HSA-4086398 5.702869e-01 0.244 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 5.756948e-01 0.240 0 0
RAS processing R-HSA-9648002 5.766565e-01 0.239 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 5.768236e-01 0.239 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 5.769301e-01 0.239 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 5.769301e-01 0.239 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 5.769301e-01 0.239 0 0
Choline catabolism R-HSA-6798163 5.769301e-01 0.239 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 5.799104e-01 0.237 0 0
Cellular response to starvation R-HSA-9711097 5.852294e-01 0.233 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 5.855715e-01 0.232 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 5.855715e-01 0.232 0 0
IFNG signaling activates MAPKs R-HSA-9732724 5.855715e-01 0.232 0 0
Recycling of eIF2:GDP R-HSA-72731 5.855715e-01 0.232 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 5.855715e-01 0.232 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 5.855715e-01 0.232 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 5.855715e-01 0.232 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 5.855715e-01 0.232 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 5.855715e-01 0.232 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 5.855715e-01 0.232 0 0
VLDL clearance R-HSA-8964046 5.855715e-01 0.232 0 0
CHL1 interactions R-HSA-447041 5.855715e-01 0.232 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 5.934668e-01 0.227 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 5.934668e-01 0.227 0 0
Signaling by Erythropoietin R-HSA-9006335 5.951921e-01 0.225 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 5.951921e-01 0.225 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 5.991301e-01 0.222 0 0
Ephrin signaling R-HSA-3928664 6.010045e-01 0.221 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 6.010045e-01 0.221 0 0
Nephron development R-HSA-9831926 6.010045e-01 0.221 0 0
Insulin receptor signalling cascade R-HSA-74751 6.077580e-01 0.216 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 6.098747e-01 0.215 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 6.140959e-01 0.212 0 0
Translation of Structural Proteins R-HSA-9694635 6.203224e-01 0.207 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 6.205264e-01 0.207 0 0
phospho-PLA2 pathway R-HSA-111995 6.205264e-01 0.207 0 0
MET receptor recycling R-HSA-8875656 6.205264e-01 0.207 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 6.205264e-01 0.207 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 6.205264e-01 0.207 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 6.205264e-01 0.207 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 6.205264e-01 0.207 0 0
TGFBR3 PTM regulation R-HSA-9839383 6.205264e-01 0.207 0 0
SLC-mediated bile acid transport R-HSA-9958517 6.205264e-01 0.207 0 0
Alpha-defensins R-HSA-1462054 6.205264e-01 0.207 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 6.205264e-01 0.207 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 6.208506e-01 0.207 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 6.208506e-01 0.207 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 6.208506e-01 0.207 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 6.240297e-01 0.205 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 6.240297e-01 0.205 0 0
Maturation of nucleoprotein R-HSA-9694631 6.240297e-01 0.205 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 6.258684e-01 0.204 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 6.258684e-01 0.204 0 0
MyD88-independent TLR4 cascade R-HSA-166166 6.317230e-01 0.199 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 6.317230e-01 0.199 0 0
ABC transporter disorders R-HSA-5619084 6.323197e-01 0.199 0 0
Cellular response to chemical stress R-HSA-9711123 6.348289e-01 0.197 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 6.365965e-01 0.196 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 6.414385e-01 0.193 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 6.460113e-01 0.190 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 6.460113e-01 0.190 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 6.460113e-01 0.190 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 6.460113e-01 0.190 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 6.460113e-01 0.190 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 6.460113e-01 0.190 0 0
Signal transduction by L1 R-HSA-445144 6.460113e-01 0.190 0 0
Signaling by NODAL R-HSA-1181150 6.460113e-01 0.190 0 0
Formation of definitive endoderm R-HSA-9823730 6.460113e-01 0.190 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 6.500826e-01 0.187 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 6.500826e-01 0.187 0 0
Disorders of transmembrane transporters R-HSA-5619115 6.518038e-01 0.186 0 0
ALK mutants bind TKIs R-HSA-9700645 6.525350e-01 0.185 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 6.525350e-01 0.185 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 6.525350e-01 0.185 0 0
Calcineurin activates NFAT R-HSA-2025928 6.525350e-01 0.185 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 6.525350e-01 0.185 0 0
Interleukin-1 processing R-HSA-448706 6.525350e-01 0.185 0 0
p75NTR regulates axonogenesis R-HSA-193697 6.525350e-01 0.185 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 6.525350e-01 0.185 0 0
Regulation of signaling by NODAL R-HSA-1433617 6.525350e-01 0.185 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 6.525350e-01 0.185 0 0
Regulated proteolysis of p75NTR R-HSA-193692 6.525350e-01 0.185 0 0
Cellular response to mitochondrial stress R-HSA-9840373 6.525350e-01 0.185 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 6.525350e-01 0.185 0 0
SLC transporter disorders R-HSA-5619102 6.601975e-01 0.180 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 6.637234e-01 0.178 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 6.669617e-01 0.176 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 6.669836e-01 0.176 0 0
Cardiogenesis R-HSA-9733709 6.671542e-01 0.176 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 6.671542e-01 0.176 0 0
RMTs methylate histone arginines R-HSA-3214858 6.712800e-01 0.173 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 6.818454e-01 0.166 0 0
Binding and entry of HIV virion R-HSA-173107 6.818454e-01 0.166 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 6.818454e-01 0.166 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 6.818454e-01 0.166 0 0
2-LTR circle formation R-HSA-164843 6.818454e-01 0.166 0 0
Tandem pore domain potassium channels R-HSA-1296346 6.818454e-01 0.166 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 6.818454e-01 0.166 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 6.836091e-01 0.165 0 0
Effects of PIP2 hydrolysis R-HSA-114508 6.836091e-01 0.165 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 6.836091e-01 0.165 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 6.836091e-01 0.165 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 6.855423e-01 0.164 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 6.889408e-01 0.162 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 6.891410e-01 0.162 0 0
Diseases of DNA repair R-HSA-9675135 6.993625e-01 0.155 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 6.994491e-01 0.155 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 6.994491e-01 0.155 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 6.994491e-01 0.155 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 7.007180e-01 0.154 0 0
Extension of Telomeres R-HSA-180786 7.018685e-01 0.154 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 7.018685e-01 0.154 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 7.058429e-01 0.151 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 7.058429e-01 0.151 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 7.086850e-01 0.150 0 0
LGI-ADAM interactions R-HSA-5682910 7.086850e-01 0.150 0 0
vRNP Assembly R-HSA-192905 7.086850e-01 0.150 0 0
Synthesis of PI R-HSA-1483226 7.086850e-01 0.150 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 7.086850e-01 0.150 0 0
Suppression of apoptosis R-HSA-9635465 7.086850e-01 0.150 0 0
Transport of RCbl within the body R-HSA-9758890 7.086850e-01 0.150 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.086850e-01 0.150 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 7.146786e-01 0.146 0 0
Potential therapeutics for SARS R-HSA-9679191 7.162142e-01 0.145 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 7.238213e-01 0.140 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 7.238213e-01 0.140 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 7.238213e-01 0.140 0 0
Growth hormone receptor signaling R-HSA-982772 7.238213e-01 0.140 0 0
Aquaporin-mediated transport R-HSA-445717 7.255703e-01 0.139 0 0
GPER1 signaling R-HSA-9634597 7.256763e-01 0.139 0 0
Gluconeogenesis R-HSA-70263 7.256763e-01 0.139 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.282443e-01 0.138 0 0
Glycosphingolipid transport R-HSA-9845576 7.293040e-01 0.137 0 0
RUNX2 regulates bone development R-HSA-8941326 7.293040e-01 0.137 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 7.312001e-01 0.136 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 7.325702e-01 0.135 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 7.325702e-01 0.135 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 7.332618e-01 0.135 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 7.332618e-01 0.135 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 7.332618e-01 0.135 0 0
Integration of provirus R-HSA-162592 7.332618e-01 0.135 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 7.332618e-01 0.135 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 7.332618e-01 0.135 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 7.332618e-01 0.135 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 7.332618e-01 0.135 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 7.332618e-01 0.135 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 7.369136e-01 0.133 0 0
Gap junction trafficking and regulation R-HSA-157858 7.381733e-01 0.132 0 0
Ion channel transport R-HSA-983712 7.391270e-01 0.131 1 0
Chaperonin-mediated protein folding R-HSA-390466 7.396334e-01 0.131 0 0
Pyruvate metabolism R-HSA-70268 7.396334e-01 0.131 0 0
Mitochondrial RNA degradation R-HSA-9836573 7.408613e-01 0.130 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 7.557665e-01 0.122 0 0
Maple Syrup Urine Disease R-HSA-9865114 7.557665e-01 0.122 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 7.557665e-01 0.122 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 7.557665e-01 0.122 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 7.557665e-01 0.122 0 0
GRB2 events in EGFR signaling R-HSA-179812 7.557665e-01 0.122 0 0
Signaling by LTK R-HSA-9842663 7.557665e-01 0.122 0 0
MET activates RAS signaling R-HSA-8851805 7.557665e-01 0.122 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 7.557665e-01 0.122 0 0
Disorders of Nervous System Development R-HSA-9697154 7.557665e-01 0.122 0 0
Pervasive developmental disorders R-HSA-9005895 7.557665e-01 0.122 0 0
Interleukin-15 signaling R-HSA-8983432 7.557665e-01 0.122 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 7.566057e-01 0.121 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 7.566057e-01 0.121 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 7.567774e-01 0.121 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 7.569935e-01 0.121 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 7.569935e-01 0.121 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.569935e-01 0.121 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 7.569935e-01 0.121 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.569935e-01 0.121 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 7.569935e-01 0.121 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 7.569935e-01 0.121 0 0
Interleukin-7 signaling R-HSA-1266695 7.569935e-01 0.121 0 0
Ion transport by P-type ATPases R-HSA-936837 7.585269e-01 0.120 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 7.696469e-01 0.114 0 0
Signaling by ALK R-HSA-201556 7.696469e-01 0.114 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 7.696469e-01 0.114 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 7.696976e-01 0.114 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 7.722496e-01 0.112 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 7.722496e-01 0.112 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 7.722496e-01 0.112 0 0
Sphingolipid catabolism R-HSA-9845614 7.722496e-01 0.112 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 7.730695e-01 0.112 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 7.763737e-01 0.110 0 0
Adenylate cyclase activating pathway R-HSA-170660 7.763737e-01 0.110 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 7.763737e-01 0.110 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 7.763737e-01 0.110 0 0
Chylomicron remodeling R-HSA-8963901 7.763737e-01 0.110 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 7.763737e-01 0.110 0 0
rRNA modification in the mitochondrion R-HSA-6793080 7.763737e-01 0.110 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 7.763737e-01 0.110 0 0
Interleukin-6 signaling R-HSA-1059683 7.763737e-01 0.110 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 7.819545e-01 0.107 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 7.866626e-01 0.104 0 0
Signaling by FGFR3 in disease R-HSA-5655332 7.866626e-01 0.104 0 0
Protein folding R-HSA-391251 7.924359e-01 0.101 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 7.924359e-01 0.101 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 7.924359e-01 0.101 0 0
Removal of the Flap Intermediate R-HSA-69166 7.952433e-01 0.099 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 7.952433e-01 0.099 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 7.952433e-01 0.099 0 0
Hydrolysis of LPC R-HSA-1483115 7.952433e-01 0.099 0 0
Retrograde neurotrophin signalling R-HSA-177504 7.952433e-01 0.099 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 7.952433e-01 0.099 0 0
Physiological factors R-HSA-5578768 7.952433e-01 0.099 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 7.952433e-01 0.099 0 0
Acyl chain remodeling of CL R-HSA-1482798 7.952433e-01 0.099 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 7.977161e-01 0.098 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 8.002661e-01 0.097 0 0
Pyroptosis R-HSA-5620971 8.002661e-01 0.097 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.125217e-01 0.090 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.125217e-01 0.090 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.125217e-01 0.090 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.125217e-01 0.090 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.125217e-01 0.090 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 8.125217e-01 0.090 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 8.130941e-01 0.090 0 0
Glucagon-type ligand receptors R-HSA-420092 8.130941e-01 0.090 0 0
Mitochondrial biogenesis R-HSA-1592230 8.132293e-01 0.090 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.198024e-01 0.086 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.206731e-01 0.086 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 8.236867e-01 0.084 0 0
DAP12 signaling R-HSA-2424491 8.251805e-01 0.083 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 8.251805e-01 0.083 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 8.251805e-01 0.083 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 8.251805e-01 0.083 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 8.251805e-01 0.083 0 0
Signaling by SCF-KIT R-HSA-1433557 8.258494e-01 0.083 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 8.283430e-01 0.082 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 8.283430e-01 0.082 0 0
Phase 4 - resting membrane potential R-HSA-5576886 8.283430e-01 0.082 0 0
Virus Assembly and Release R-HSA-168268 8.283430e-01 0.082 0 0
Cardiac conduction R-HSA-5576891 8.317077e-01 0.080 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 8.317208e-01 0.080 0 0
Proteasome assembly R-HSA-9907900 8.355657e-01 0.078 0 0
Netrin-1 signaling R-HSA-373752 8.355657e-01 0.078 0 0
Gap junction trafficking R-HSA-190828 8.355657e-01 0.078 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 8.365591e-01 0.078 0 0
Downstream signal transduction R-HSA-186763 8.365591e-01 0.078 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.365591e-01 0.078 0 0
Molecules associated with elastic fibres R-HSA-2129379 8.365591e-01 0.078 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 8.394540e-01 0.076 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 8.402036e-01 0.076 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 8.428300e-01 0.074 0 0
Phase 2 - plateau phase R-HSA-5576893 8.428300e-01 0.074 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 8.428300e-01 0.074 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 8.428300e-01 0.074 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 8.428300e-01 0.074 0 0
Passive transport by Aquaporins R-HSA-432047 8.428300e-01 0.074 0 0
Disorders of Developmental Biology R-HSA-9675151 8.428300e-01 0.074 0 0
Somitogenesis R-HSA-9824272 8.448109e-01 0.073 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 8.475393e-01 0.072 0 0
Neddylation R-HSA-8951664 8.502195e-01 0.070 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.524151e-01 0.069 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.536016e-01 0.069 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 8.560952e-01 0.067 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 8.560952e-01 0.067 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 8.560952e-01 0.067 0 0
Signaling by PDGF R-HSA-186797 8.634127e-01 0.064 0 0
NCAM signaling for neurite out-growth R-HSA-375165 8.634127e-01 0.064 0 0
Integration of energy metabolism R-HSA-163685 8.644141e-01 0.063 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 8.662504e-01 0.062 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.667786e-01 0.062 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 8.682415e-01 0.061 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 8.682415e-01 0.061 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 8.682415e-01 0.061 0 0
Metal ion SLC transporters R-HSA-425410 8.698849e-01 0.061 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 8.704798e-01 0.060 0 0
Integrin cell surface interactions R-HSA-216083 8.738442e-01 0.059 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.756530e-01 0.058 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 8.756530e-01 0.058 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 8.793633e-01 0.056 0 0
Pyrimidine biosynthesis R-HSA-500753 8.793633e-01 0.056 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 8.793633e-01 0.056 0 0
E2F mediated regulation of DNA replication R-HSA-113510 8.793633e-01 0.056 0 0
The NLRP3 inflammasome R-HSA-844456 8.793633e-01 0.056 0 0
Specification of the neural plate border R-HSA-9834899 8.793633e-01 0.056 0 0
Interferon alpha/beta signaling R-HSA-909733 8.795327e-01 0.056 0 0
Sensory processing of sound R-HSA-9659379 8.799172e-01 0.056 0 0
Toll-like Receptor Cascades R-HSA-168898 8.823847e-01 0.054 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 8.839792e-01 0.054 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 8.839792e-01 0.054 0 0
Signaling by Insulin receptor R-HSA-74752 8.839809e-01 0.054 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 8.895468e-01 0.051 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 8.895468e-01 0.051 0 0
Acyl chain remodelling of PI R-HSA-1482922 8.895468e-01 0.051 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 8.895468e-01 0.051 0 0
Protein hydroxylation R-HSA-9629569 8.895468e-01 0.051 0 0
The phototransduction cascade R-HSA-2514856 8.913101e-01 0.050 0 0
GPVI-mediated activation cascade R-HSA-114604 8.917865e-01 0.050 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.917865e-01 0.050 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 8.977160e-01 0.047 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 8.988713e-01 0.046 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 8.988713e-01 0.046 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 8.988713e-01 0.046 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 8.988713e-01 0.046 0 0
Abacavir metabolism R-HSA-2161541 8.988713e-01 0.046 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 8.988713e-01 0.046 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 8.988713e-01 0.046 0 0
Acyl chain remodelling of PG R-HSA-1482925 8.988713e-01 0.046 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.037243e-01 0.044 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.037799e-01 0.044 0 0
Elastic fibre formation R-HSA-1566948 9.059562e-01 0.043 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 9.074091e-01 0.042 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.074091e-01 0.042 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.074091e-01 0.042 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.074091e-01 0.042 0 0
Serine metabolism R-HSA-977347 9.074091e-01 0.042 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 9.074091e-01 0.042 0 0
COPI-mediated anterograde transport R-HSA-6807878 9.083841e-01 0.042 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.149417e-01 0.039 0 0
G alpha (z) signalling events R-HSA-418597 9.149417e-01 0.039 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 9.152266e-01 0.038 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.152266e-01 0.038 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 9.152266e-01 0.038 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.152266e-01 0.038 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 9.152266e-01 0.038 0 0
Cellular hexose transport R-HSA-189200 9.152266e-01 0.038 0 0
Ethanol oxidation R-HSA-71384 9.152266e-01 0.038 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.152266e-01 0.038 0 0
LDL clearance R-HSA-8964038 9.152266e-01 0.038 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.152266e-01 0.038 0 0
Regulation of insulin secretion R-HSA-422356 9.168260e-01 0.038 0 0
Generation of second messenger molecules R-HSA-202433 9.183752e-01 0.037 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.183752e-01 0.037 0 0
Diseases of Immune System R-HSA-5260271 9.183752e-01 0.037 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.183752e-01 0.037 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.183752e-01 0.037 0 0
XBP1(S) activates chaperone genes R-HSA-381038 9.200808e-01 0.036 0 0
Hemostasis R-HSA-109582 9.202097e-01 0.036 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.223845e-01 0.035 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.223845e-01 0.035 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.223845e-01 0.035 0 0
Carnitine shuttle R-HSA-200425 9.223845e-01 0.035 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 9.223845e-01 0.035 0 0
Selenoamino acid metabolism R-HSA-2408522 9.246572e-01 0.034 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 9.289384e-01 0.032 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 9.289384e-01 0.032 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.289384e-01 0.032 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 9.289384e-01 0.032 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.289384e-01 0.032 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.289384e-01 0.032 0 0
Complex III assembly R-HSA-9865881 9.289384e-01 0.032 0 0
Interleukin-6 family signaling R-HSA-6783589 9.289384e-01 0.032 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.292390e-01 0.032 0 0
HIV Transcription Initiation R-HSA-167161 9.292390e-01 0.032 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.292390e-01 0.032 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.292390e-01 0.032 0 0
Protein localization R-HSA-9609507 9.330218e-01 0.030 0 0
Iron uptake and transport R-HSA-917937 9.334634e-01 0.030 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.337997e-01 0.030 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.349392e-01 0.029 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 9.349392e-01 0.029 0 0
Tight junction interactions R-HSA-420029 9.349392e-01 0.029 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.349392e-01 0.029 0 0
Hyaluronan degradation R-HSA-2160916 9.349392e-01 0.029 0 0
Laminin interactions R-HSA-3000157 9.349392e-01 0.029 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.349392e-01 0.029 0 0
Metabolism of polyamines R-HSA-351202 9.378702e-01 0.028 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.387255e-01 0.027 0 0
MET activates PTK2 signaling R-HSA-8874081 9.404336e-01 0.027 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.404336e-01 0.027 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.404336e-01 0.027 0 0
Abacavir ADME R-HSA-2161522 9.404336e-01 0.027 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.407308e-01 0.027 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.417083e-01 0.026 0 0
IRE1alpha activates chaperones R-HSA-381070 9.418977e-01 0.026 0 0
DAP12 interactions R-HSA-2172127 9.430033e-01 0.025 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.430033e-01 0.025 0 0
Amine ligand-binding receptors R-HSA-375280 9.430033e-01 0.025 0 0
tRNA processing R-HSA-72306 9.430739e-01 0.025 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.454643e-01 0.024 0 0
Cristae formation R-HSA-8949613 9.454643e-01 0.024 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.454643e-01 0.024 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 9.454643e-01 0.024 0 0
Triglyceride biosynthesis R-HSA-75109 9.454643e-01 0.024 0 0
Insulin processing R-HSA-264876 9.454643e-01 0.024 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 9.459203e-01 0.024 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.469960e-01 0.024 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.472676e-01 0.024 0 0
Telomere Extension By Telomerase R-HSA-171319 9.500704e-01 0.022 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.500704e-01 0.022 0 0
Inflammasomes R-HSA-622312 9.500704e-01 0.022 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.507211e-01 0.022 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.507211e-01 0.022 0 0
Platelet calcium homeostasis R-HSA-418360 9.542877e-01 0.020 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.542877e-01 0.020 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 9.542877e-01 0.020 0 0
Intraflagellar transport R-HSA-5620924 9.574347e-01 0.019 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.581491e-01 0.019 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.584007e-01 0.018 0 0
Formation of the cornified envelope R-HSA-6809371 9.585290e-01 0.018 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.604538e-01 0.018 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.604779e-01 0.018 0 0
Azathioprine ADME R-HSA-9748787 9.632669e-01 0.016 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.641410e-01 0.016 0 0
DAG1 glycosylations R-HSA-8931838 9.649214e-01 0.016 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.649214e-01 0.016 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.658329e-01 0.015 0 0
Parasite infection R-HSA-9664407 9.658329e-01 0.015 0 0
Leishmania phagocytosis R-HSA-9664417 9.658329e-01 0.015 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.658871e-01 0.015 0 0
PPARA activates gene expression R-HSA-1989781 9.675390e-01 0.014 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 9.678850e-01 0.014 0 0
Phospholipid metabolism R-HSA-1483257 9.679478e-01 0.014 0 0
Translation R-HSA-72766 9.684649e-01 0.014 0 0
Metabolism of cofactors R-HSA-8978934 9.696588e-01 0.013 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.704486e-01 0.013 0 0
Nucleotide biosynthesis R-HSA-8956320 9.705983e-01 0.013 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.705984e-01 0.013 0 0
Heme degradation R-HSA-189483 9.705984e-01 0.013 0 0
G alpha (s) signalling events R-HSA-418555 9.706957e-01 0.013 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.716165e-01 0.013 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.730827e-01 0.012 0 0
Hyaluronan metabolism R-HSA-2142845 9.730827e-01 0.012 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.730827e-01 0.012 0 0
Signal amplification R-HSA-392518 9.730827e-01 0.012 0 0
Infectious disease R-HSA-5663205 9.744212e-01 0.011 0 0
Paracetamol ADME R-HSA-9753281 9.746788e-01 0.011 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.753573e-01 0.011 0 0
PERK regulates gene expression R-HSA-381042 9.753573e-01 0.011 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.753573e-01 0.011 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.767960e-01 0.010 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.774397e-01 0.010 0 0
Platelet homeostasis R-HSA-418346 9.776804e-01 0.010 0 0
Gastrulation R-HSA-9758941 9.791774e-01 0.009 0 0
Voltage gated Potassium channels R-HSA-1296072 9.793463e-01 0.009 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.793463e-01 0.009 0 0
NCAM1 interactions R-HSA-419037 9.793463e-01 0.009 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.793463e-01 0.009 0 0
Lysine catabolism R-HSA-71064 9.793463e-01 0.009 0 0
Collagen chain trimerization R-HSA-8948216 9.793463e-01 0.009 0 0
Metabolism of folate and pterines R-HSA-196757 9.793463e-01 0.009 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.797907e-01 0.009 0 0
Leishmania infection R-HSA-9658195 9.809217e-01 0.008 0 0
Parasitic Infection Pathways R-HSA-9824443 9.809217e-01 0.008 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.810679e-01 0.008 0 0
Cholesterol biosynthesis R-HSA-191273 9.810679e-01 0.008 0 0
Collagen formation R-HSA-1474290 9.812900e-01 0.008 0 0
Mitochondrial protein degradation R-HSA-9837999 9.812900e-01 0.008 0 0
tRNA Aminoacylation R-HSA-379724 9.826266e-01 0.008 0 0
Pentose phosphate pathway R-HSA-71336 9.826900e-01 0.008 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.841531e-01 0.007 0 0
Mitochondrial protein import R-HSA-1268020 9.850744e-01 0.007 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.854927e-01 0.006 0 0
Maturation of spike protein R-HSA-9694548 9.854927e-01 0.006 0 0
Extracellular matrix organization R-HSA-1474244 9.858327e-01 0.006 0 0
Neuronal System R-HSA-112316 9.859749e-01 0.006 0 0
Intra-Golgi traffic R-HSA-6811438 9.867191e-01 0.006 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.867191e-01 0.006 0 0
Heme biosynthesis R-HSA-189451 9.867191e-01 0.006 0 0
Activation of GABAB receptors R-HSA-991365 9.878419e-01 0.005 0 0
GABA B receptor activation R-HSA-977444 9.878419e-01 0.005 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.878419e-01 0.005 0 0
Defensins R-HSA-1461973 9.888698e-01 0.005 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.898108e-01 0.004 0 0
Nicotinate metabolism R-HSA-196807 9.898167e-01 0.004 0 0
Kidney development R-HSA-9830369 9.898167e-01 0.004 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.900186e-01 0.004 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.919180e-01 0.004 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.919696e-01 0.004 0 0
Synthesis of PC R-HSA-1483191 9.921833e-01 0.003 0 0
Neurotransmitter release cycle R-HSA-112310 9.923188e-01 0.003 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.923188e-01 0.003 0 0
Metabolism of porphyrins R-HSA-189445 9.925192e-01 0.003 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.928443e-01 0.003 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.942148e-01 0.003 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.944745e-01 0.002 0 0
Complex IV assembly R-HSA-9864848 9.945108e-01 0.002 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.956535e-01 0.002 0 0
Potassium Channels R-HSA-1296071 9.956535e-01 0.002 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.956603e-01 0.002 0 0
Interleukin-10 signaling R-HSA-6783783 9.956603e-01 0.002 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.962359e-01 0.002 0 0
Transmission across Chemical Synapses R-HSA-112315 9.967610e-01 0.001 0 0
Dectin-2 family R-HSA-5621480 9.967703e-01 0.001 0 0
Synthesis of PA R-HSA-1483166 9.967703e-01 0.001 0 0
Disease R-HSA-1643685 9.970245e-01 0.001 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.970436e-01 0.001 0 0
Triglyceride metabolism R-HSA-8979227 9.972938e-01 0.001 0 0
GABA receptor activation R-HSA-977443 9.975228e-01 0.001 0 0
Collagen degradation R-HSA-1442490 9.977325e-01 0.001 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.978622e-01 0.001 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.978994e-01 0.001 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.978994e-01 0.001 0 0
Complex I biogenesis R-HSA-6799198 9.981001e-01 0.001 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.983004e-01 0.001 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.985997e-01 0.001 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.987415e-01 0.001 0 0
Innate Immune System R-HSA-168249 9.987523e-01 0.001 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.987792e-01 0.001 0 0
Sphingolipid metabolism R-HSA-428157 9.988817e-01 0.000 0 0
COPII-mediated vesicle transport R-HSA-204005 9.989772e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.989924e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.990131e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.990352e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.990638e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.990638e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.990638e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.991316e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.991316e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.992821e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.993538e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.995389e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.996137e-01 0.000 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.996490e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.997049e-01 0.000 0 0
Keratinization R-HSA-6805567 9.997448e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.997549e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.997740e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.998882e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999061e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999216e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999325e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999343e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999430e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999556e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999579e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999647e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999662e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999664e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999666e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999739e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999773e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999907e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999927e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999953e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999954e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999961e-01 0.000 1 0
G alpha (i) signalling events R-HSA-418594 9.999974e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999976e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999981e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999987e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999988e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999989e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999995e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999995e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999996e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999997e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999997e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999998e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999999e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways