ROR2

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
Y Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: Y Sites / Y Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
A5A3E0 S939 Sugiyama POTEF A26C1B VALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPE
O43707 Y906 Sugiyama ACTN4 yQGPDAVPGALDyKsFStALyGEsDL_______________
O60361 Y136 Sugiyama NME2P1 SLRFKPEELVDYKSCAHDWVyE___________________
P00558 Y161 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 KAEPAKIEAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNL
P04406 Y314 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 tFDAGAGIALNDHFVKLIsWyDNEFGysNRVVDLMAHMAsK
P04406 Y320 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 GIALNDHFVKLIsWyDNEFGysNRVVDLMAHMAsKE_____
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05386 S104 Sugiyama RPLP1 RRP1 tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387 S105 Sugiyama RPLP2 D11S2243E RPP2 GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P06733 Y270 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 EFFRsGKyDLDFKsPDDPsRyIsPDQLADLyKsFIKDyPVV
P06733 Y280 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 DFKsPDDPsRyIsPDQLADLyKsFIKDyPVVsIEDPFDQDD
P06733 Y44 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 LFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKGVSK
P07205 Y161 Sugiyama PGK2 PGKB KAEPDKIEAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNL
P07355 S184 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D sGDFRKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVK
P07814 Y827 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 EIGQNIssNssAsILESKsLyDEVAAQGEVVRKLKAEKSPK
P07900 Y309 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA ELNKtKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHF
P07900 Y313 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA tKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEG
P08238 Y301 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB ELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHF
P08238 Y305 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB tKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEG
P11142 T427 Sugiyama HSPA8 HSC70 HSP73 HSPA10 GGVMTVLIKRNtTIPTKQtQtFttysDNQPGVLIQVyEGER
P11142 Y443 Sugiyama HSPA8 HSC70 HSP73 HSPA10 KQtQtFttysDNQPGVLIQVyEGERAMTKDNNLLGKFELTG
P13667 T449 Sugiyama PDIA4 ERP70 ERP72 AATQFWRSKVLEVAKDFPEytFAIADEEDyAGEVKDLGLsE
P13667 Y458 Sugiyama PDIA4 ERP70 ERP72 VLEVAKDFPEytFAIADEEDyAGEVKDLGLsEsGEDVNAAI
P22392 Y151 Sugiyama NME2 NM23B SLWFKPEELVDyKSCAHDWVyE___________________
P23588 Y609 Sugiyama EIF4B sASKyAALsVDGEDENEGEDyAE__________________
P29320 Y596 Sugiyama EPHA3 ETK ETK1 HEK TYRO4 ADEKRLHFGNGHLKLPGLRtyVDPHtyEDPtQAVHEFAKEL
P29320 Y937 Sugiyama EPHA3 ETK ETK1 HEK TYRO4 GDWLNGVWTAHCKEIFtGVEyssCDTIAKISTDDMKKVGVT
P30101 Y264 Sugiyama PDIA3 ERP57 ERP60 GRP58 CPHMTEDNKDLIQGKDLLIAyyDVDyEKNAKGSNYWRNRVM
P30101 Y265 Sugiyama PDIA3 ERP57 ERP60 GRP58 PHMTEDNKDLIQGKDLLIAyyDVDyEKNAKGSNYWRNRVMM
P39019 Y48 Sugiyama RPS19 LKVPEWVDtVKLAKHKELAPyDENWFytRAAstARHLYLRG
P39019 Y54 Sugiyama RPS19 VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P60660 Y86 Sugiyama MYL6 DFEHFLPMLQTVAKNKDQGtyEDyVEGLRVFDKEGNGtVMG
P60660 Y89 Sugiyama MYL6 HFLPMLQTVAKNKDQGtyEDyVEGLRVFDKEGNGtVMGAEI
P60709 S239 Sugiyama ACTB VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P60709 T297 Sugiyama ACTB TTFNSIMKCDVDIRKDLyANtVLsGGttMyPGIADRMQKEI
P60709 Y306 Sugiyama ACTB DVDIRKDLyANtVLsGGttMyPGIADRMQKEItALAPstMK
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62736 S241 Sugiyama ACTA2 ACTSA ACTVS GIG46 VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P62750 Y144 Sugiyama RPL23A VNtLIRPDGEKKAYVRLAPDyDALDVANKIGII________
P63261 S239 Sugiyama ACTG1 ACTG VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63261 T297 Sugiyama ACTG1 ACTG TTFNSIMKCDVDIRKDLyANtVLsGGttMyPGIADRMQKEI
P63261 Y306 Sugiyama ACTG1 ACTG DVDIRKDLyANtVLsGGttMyPGIADRMQKEItALAPstMK
P63267 S240 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68032 S241 Sugiyama ACTC1 ACTC VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68133 S241 Sugiyama ACTA1 ACTA VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68363 Y432 Sugiyama TUBA1B GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
P68363 Y451 Sugiyama TUBA1B DyEEVGVDsVEGEGEEEGEEy____________________
Q01974 S447 Sugiyama ROR2 NTRKR2 MCRNKQKASASTPQRRQLMAsPsQDMEMPLINQHKQAKLKE
Q01974 S469 Sugiyama ROR2 NTRKR2 sQDMEMPLINQHKQAKLKEIsLSAVRFMEELGEDRFGKVYK
Q15293 Y278 Sugiyama RCN1 RCN LNKDGKLDKDEIRHWILPQDyDHAQAEARHLVyESDKNKDE
Q562R1 S240 Sugiyama ACTBL2 VALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPE
Q6S8J3 S939 Sugiyama POTEE A26C1A POTE2 VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
Q71U36 Y432 Sugiyama TUBA1A TUBA3 GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q71U36 Y451 Sugiyama TUBA1A TUBA3 DyEEVGVDsVEGEGEEEGEEy____________________
Q92882 Y207 Sugiyama OSTF1 sLLKKKQGTDAVRtLsNAEDyLDDEDsD_____________
Q9BQE3 Y432 Sugiyama TUBA1C TUBA6 GMEEGEFSEAREDMAALEKDyEEVGADsADGEDEGEEy___
Q9BYX7 S239 Sugiyama POTEKP ACTBL3 FKSG30 VALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPE
Q9H1E3 Y146 Sugiyama NUCKS1 NUCKS JC7 QEKDsGsDEDFLMEDDDDsDyGSsKKKNKKMVKKSKPERKE
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Regulation of CDH1 Function R-HSA-9764561 1.003766e-09 8.998 0 0
Smooth Muscle Contraction R-HSA-445355 6.398122e-09 8.194 0 0
Axon guidance R-HSA-422475 4.523805e-08 7.344 0 0
Nervous system development R-HSA-9675108 1.690282e-07 6.772 0 0
Signal Transduction R-HSA-162582 2.343166e-07 6.630 1 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 2.639599e-07 6.578 0 0
EPH-Ephrin signaling R-HSA-2682334 1.032017e-06 5.986 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.313435e-06 5.882 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 3.686509e-06 5.433 0 0
Striated Muscle Contraction R-HSA-390522 4.594004e-06 5.338 0 0
Muscle contraction R-HSA-397014 6.480548e-06 5.188 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 7.880662e-06 5.103 0 0
Apoptosis R-HSA-109581 8.550558e-06 5.068 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.672757e-05 4.777 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.672757e-05 4.777 0 0
Programmed Cell Death R-HSA-5357801 2.004005e-05 4.698 0 0
Somitogenesis R-HSA-9824272 2.764574e-05 4.558 0 0
Cell junction organization R-HSA-446728 3.055885e-05 4.515 0 0
Adherens junctions interactions R-HSA-418990 3.666688e-05 4.436 0 0
Cell-cell junction organization R-HSA-421270 3.853549e-05 4.414 0 0
Cell-Cell communication R-HSA-1500931 3.606057e-05 4.443 0 0
Gluconeogenesis R-HSA-70263 3.903773e-05 4.409 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 3.394266e-05 4.469 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 5.278883e-05 4.277 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 5.254399e-05 4.279 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 6.771988e-05 4.169 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 7.724426e-05 4.112 0 0
Neutrophil degranulation R-HSA-6798695 1.024397e-04 3.990 0 0
G2/M Checkpoints R-HSA-69481 1.150454e-04 3.939 0 0
Aggrephagy R-HSA-9646399 1.249355e-04 3.903 0 0
Metabolism of RNA R-HSA-8953854 1.245030e-04 3.905 0 0
Formation of paraxial mesoderm R-HSA-9793380 1.413432e-04 3.850 0 0
G2/M Transition R-HSA-69275 1.375281e-04 3.862 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.502818e-04 3.823 0 0
Deubiquitination R-HSA-5688426 1.651295e-04 3.782 0 0
TCR signaling R-HSA-202403 1.791360e-04 3.747 0 0
Developmental Biology R-HSA-1266738 1.783203e-04 3.749 0 0
Ribosome-associated quality control R-HSA-9948299 2.309515e-04 3.636 0 0
PTEN Regulation R-HSA-6807070 2.429244e-04 3.615 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 2.542119e-04 3.595 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.689532e-04 3.570 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 3.562018e-04 3.448 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 3.507775e-04 3.455 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 3.483879e-04 3.458 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 3.483879e-04 3.458 0 0
Gap junction trafficking and regulation R-HSA-157858 3.483879e-04 3.458 0 0
Ub-specific processing proteases R-HSA-5689880 3.109787e-04 3.507 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 3.730569e-04 3.428 0 0
Signaling by NOTCH4 R-HSA-9013694 3.975515e-04 3.401 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 4.018038e-04 3.396 0 0
Orc1 removal from chromatin R-HSA-68949 4.555818e-04 3.341 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 4.466322e-04 3.350 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 4.732409e-04 3.325 0 0
Signaling by VEGF R-HSA-194138 4.833584e-04 3.316 0 0
Cellular responses to stimuli R-HSA-8953897 5.199579e-04 3.284 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 5.652667e-04 3.248 0 0
Signaling by Interleukins R-HSA-449147 7.815300e-04 3.107 0 0
Intracellular signaling by second messengers R-HSA-9006925 8.278277e-04 3.082 0 0
Stabilization of p53 R-HSA-69541 9.423846e-04 3.026 0 0
Signaling by Hedgehog R-HSA-5358351 9.846574e-04 3.007 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.082507e-03 2.966 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 1.035990e-03 2.985 0 0
Manipulation of host energy metabolism R-HSA-9636667 1.106226e-03 2.956 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 1.136323e-03 2.944 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 1.136323e-03 2.944 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 1.136323e-03 2.944 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.245732e-03 2.905 0 0
CASP4 inflammasome assembly R-HSA-9948001 1.262427e-03 2.899 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.275141e-03 2.894 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.300519e-03 2.886 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.471062e-03 2.832 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.439770e-03 2.842 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 1.480633e-03 2.830 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.558385e-03 2.807 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 1.610835e-03 2.793 0 0
Gap junction trafficking R-HSA-190828 1.610835e-03 2.793 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 1.749257e-03 2.757 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 1.749257e-03 2.757 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 1.736206e-03 2.760 0 0
Apoptotic execution phase R-HSA-75153 1.896205e-03 2.722 0 0
Regulation of TP53 Expression R-HSA-6804754 1.946063e-03 2.711 0 0
Recycling pathway of L1 R-HSA-437239 2.051986e-03 2.688 0 0
Switching of origins to a post-replicative state R-HSA-69052 2.093591e-03 2.679 0 0
Hedgehog 'off' state R-HSA-5610787 2.249096e-03 2.648 0 0
Glycolysis R-HSA-70171 2.249096e-03 2.648 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 2.309799e-03 2.636 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 2.561923e-03 2.591 0 0
Regulation of RAS by GAPs R-HSA-5658442 2.575413e-03 2.589 0 0
UCH proteinases R-HSA-5689603 2.503921e-03 2.601 0 0
Degradation of CDH1 R-HSA-9766229 2.391279e-03 2.621 0 0
Interleukin-1 signaling R-HSA-9020702 2.363208e-03 2.626 0 0
Interleukin-12 signaling R-HSA-9020591 2.503921e-03 2.601 0 0
Microbial factors inhibit CASP4 activity R-HSA-9956593 2.694046e-03 2.570 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 2.694046e-03 2.570 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 2.769619e-03 2.558 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 2.769619e-03 2.558 0 0
Hedgehog ligand biogenesis R-HSA-5358346 2.769619e-03 2.558 0 0
TRKA activation by NGF R-HSA-187042 3.008974e-03 2.522 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 3.160867e-03 2.500 0 0
Regulation of PTEN stability and activity R-HSA-8948751 3.189494e-03 2.496 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 2.974208e-03 2.527 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 3.444478e-03 2.463 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 3.121620e-03 2.506 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 3.415786e-03 2.467 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 3.430453e-03 2.465 0 0
Activation of BH3-only proteins R-HSA-114452 2.832318e-03 2.548 0 0
Cell Cycle, Mitotic R-HSA-69278 3.086831e-03 2.510 0 0
Cell Cycle R-HSA-1640170 3.462027e-03 2.461 0 0
Platelet activation, signaling and aggregation R-HSA-76002 3.031618e-03 2.518 0 0
Innate Immune System R-HSA-168249 3.162857e-03 2.500 0 0
Non-canonical inflammasome activation R-HSA-9686114 3.160867e-03 2.500 0 0
Infectious disease R-HSA-5663205 3.332426e-03 2.477 0 0
SARS-CoV-1-host interactions R-HSA-9692914 3.144493e-03 2.502 0 0
Signaling by ROBO receptors R-HSA-376176 3.347519e-03 2.475 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 3.674379e-03 2.435 0 0
Protein methylation R-HSA-8876725 3.674379e-03 2.435 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 3.674379e-03 2.435 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 3.674379e-03 2.435 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 3.824960e-03 2.417 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 3.956062e-03 2.403 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 4.100394e-03 2.387 0 0
Vpu mediated degradation of CD4 R-HSA-180534 4.109167e-03 2.386 0 0
Chaperonin-mediated protein folding R-HSA-390466 4.770690e-03 2.321 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 4.846878e-03 2.315 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 4.873258e-03 2.312 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 4.873258e-03 2.312 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 4.315541e-03 2.365 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 4.480248e-03 2.349 0 0
Regulation of Apoptosis R-HSA-169911 4.873258e-03 2.312 0 0
Interleukin-12 family signaling R-HSA-447115 4.770690e-03 2.321 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 5.483994e-03 2.261 0 0
PIP3 activates AKT signaling R-HSA-1257604 5.193126e-03 2.285 0 0
HSF1 activation R-HSA-3371511 5.288770e-03 2.277 0 0
Eukaryotic Translation Initiation R-HSA-72613 5.283654e-03 2.277 0 0
Cap-dependent Translation Initiation R-HSA-72737 5.283654e-03 2.277 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 5.508316e-03 2.259 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 5.273130e-03 2.278 0 0
Degradation of DVL R-HSA-4641258 5.727343e-03 2.242 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 5.288770e-03 2.277 0 0
Degradation of AXIN R-HSA-4641257 5.727343e-03 2.242 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 5.727343e-03 2.242 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 5.659521e-03 2.247 0 0
Glucose metabolism R-HSA-70326 5.501556e-03 2.260 0 0
Downstream TCR signaling R-HSA-202424 5.518319e-03 2.258 0 0
L1CAM interactions R-HSA-373760 5.283654e-03 2.277 0 0
Cellular responses to stress R-HSA-2262752 4.928109e-03 2.307 0 0
Immune System R-HSA-168256 5.644000e-03 2.248 0 0
Selective autophagy R-HSA-9663891 5.011061e-03 2.300 0 0
Viral Infection Pathways R-HSA-9824446 5.592760e-03 2.252 0 0
Cytokine Signaling in Immune system R-HSA-1280215 5.367770e-03 2.270 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 5.998753e-03 2.222 0 0
Signaling by PTK6 R-HSA-8848021 5.998753e-03 2.222 0 0
Semaphorin interactions R-HSA-373755 5.998753e-03 2.222 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 6.062161e-03 2.217 0 0
Chaperone Mediated Autophagy R-HSA-9613829 6.221354e-03 2.206 0 0
Transport of connexons to the plasma membrane R-HSA-190872 6.221354e-03 2.206 0 0
Protein folding R-HSA-391251 6.348261e-03 2.197 0 0
MAPK family signaling cascades R-HSA-5683057 6.660625e-03 2.176 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 6.675839e-03 2.175 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 6.675839e-03 2.175 0 0
Cellular response to hypoxia R-HSA-1234174 6.719702e-03 2.173 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 7.464806e-03 2.127 0 0
Formation of a pool of free 40S subunits R-HSA-72689 7.591457e-03 2.120 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 7.911713e-03 2.102 0 0
Signaling by RAF1 mutants R-HSA-9656223 8.284748e-03 2.082 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 7.806115e-03 2.108 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 7.722954e-03 2.112 0 0
G1/S Transition R-HSA-69206 7.777662e-03 2.109 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 7.464806e-03 2.127 0 0
Degradation of CRY and PER proteins R-HSA-9932298 8.284748e-03 2.082 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 8.284748e-03 2.082 0 0
The NLRP3 inflammasome R-HSA-844456 6.986986e-03 2.156 0 0
Autophagy R-HSA-9612973 7.406413e-03 2.130 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 8.284748e-03 2.082 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 8.284748e-03 2.082 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 8.274878e-03 2.082 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 7.186815e-03 2.143 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 8.783447e-03 2.056 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 8.783447e-03 2.056 0 0
Regulation of mitotic cell cycle R-HSA-453276 9.243270e-03 2.034 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 9.243270e-03 2.034 0 0
Hedgehog 'on' state R-HSA-5632684 9.243270e-03 2.034 0 0
Co-inhibition by PD-1 R-HSA-389948 9.282941e-03 2.032 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 9.608068e-03 2.017 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 9.719427e-03 2.012 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.012875e-02 1.994 0 0
Proteasome assembly R-HSA-9907900 1.012875e-02 1.994 0 0
Hemostasis R-HSA-109582 1.051653e-02 1.978 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 1.079778e-02 1.967 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 1.079778e-02 1.967 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 1.079778e-02 1.967 0 0
Activation of TRKA receptors R-HSA-187015 1.142286e-02 1.942 0 0
Formation of annular gap junctions R-HSA-196025 1.367847e-02 1.864 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 1.163282e-02 1.934 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 1.284235e-02 1.891 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.333025e-02 1.875 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.149470e-02 1.940 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.149470e-02 1.940 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.149470e-02 1.940 0 0
Signaling by RAS mutants R-HSA-6802949 1.149470e-02 1.940 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.367847e-02 1.864 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 1.149470e-02 1.940 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.101581e-02 1.958 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 1.221991e-02 1.913 0 0
NGF-stimulated transcription R-HSA-9031628 1.297380e-02 1.887 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.168010e-02 1.933 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 1.220189e-02 1.914 1 0
Synthesis of DNA R-HSA-69239 1.284235e-02 1.891 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.358272e-02 1.867 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 1.142286e-02 1.942 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.367847e-02 1.864 0 0
ABC transporter disorders R-HSA-5619084 1.293408e-02 1.888 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.342973e-02 1.872 0 0
M Phase R-HSA-68886 1.368022e-02 1.864 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.383098e-02 1.859 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.388478e-02 1.857 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.388478e-02 1.857 0 0
PKR-mediated signaling R-HSA-9833482 1.414794e-02 1.849 0 0
Signaling by WNT R-HSA-195721 1.416723e-02 1.849 1 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.416903e-02 1.849 0 0
Translation R-HSA-72766 1.427003e-02 1.846 0 0
Macroautophagy R-HSA-1632852 1.431048e-02 1.844 0 0
Cell Cycle Checkpoints R-HSA-69620 1.482300e-02 1.829 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.541176e-02 1.812 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.541176e-02 1.812 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.569407e-02 1.804 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.583356e-02 1.800 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.583356e-02 1.800 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.583356e-02 1.800 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.583356e-02 1.800 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.583356e-02 1.800 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.583356e-02 1.800 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.583356e-02 1.800 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.583356e-02 1.800 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 1.610867e-02 1.793 0 0
Gap junction degradation R-HSA-190873 1.611009e-02 1.793 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.611009e-02 1.793 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 1.611009e-02 1.793 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 1.628327e-02 1.788 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 1.636723e-02 1.786 0 0
Signaling by BMP R-HSA-201451 1.636723e-02 1.786 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.636723e-02 1.786 0 0
SARS-CoV-2 Infection R-HSA-9694516 1.651404e-02 1.782 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.653266e-02 1.782 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.682714e-02 1.774 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 1.718578e-02 1.765 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 1.718578e-02 1.765 0 0
Inflammasomes R-HSA-622312 1.769563e-02 1.752 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.871162e-02 1.728 0 0
PECAM1 interactions R-HSA-210990 2.147711e-02 1.668 0 0
Translation initiation complex formation R-HSA-72649 1.811895e-02 1.742 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.055524e-02 1.687 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 2.305169e-02 1.637 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.222667e-02 1.653 0 0
Peptide chain elongation R-HSA-156902 2.055524e-02 1.687 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 2.110510e-02 1.676 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 2.216351e-02 1.654 0 0
Gastrulation R-HSA-9758941 1.874185e-02 1.727 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 1.871162e-02 1.728 0 0
ChREBP activates metabolic gene expression R-HSA-163765 2.147711e-02 1.668 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 1.908305e-02 1.719 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 2.007835e-02 1.697 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 2.089691e-02 1.680 0 0
Interleukin-1 family signaling R-HSA-446652 2.041188e-02 1.690 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.925330e-02 1.715 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 2.007835e-02 1.697 0 0
SARS-CoV Infections R-HSA-9679506 2.374882e-02 1.624 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 2.405807e-02 1.619 0 0
Regulation of PTEN gene transcription R-HSA-8943724 2.437618e-02 1.613 0 0
Metabolism of polyamines R-HSA-351202 2.437618e-02 1.613 0 0
Eukaryotic Translation Elongation R-HSA-156842 2.482039e-02 1.605 0 0
Signaling by NOTCH R-HSA-157118 2.508718e-02 1.601 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.521543e-02 1.598 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 2.521543e-02 1.598 0 0
Regulation of TP53 Activity R-HSA-5633007 2.536701e-02 1.596 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 2.553082e-02 1.593 0 0
Assembly of the pre-replicative complex R-HSA-68867 2.573653e-02 1.589 0 0
Extracellular matrix organization R-HSA-1474244 2.679613e-02 1.572 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 2.747553e-02 1.561 0 0
Platelet degranulation R-HSA-114608 2.757490e-02 1.559 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 2.763315e-02 1.559 0 0
Separation of Sister Chromatids R-HSA-2467813 2.812961e-02 1.551 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 2.839447e-02 1.547 0 0
Eukaryotic Translation Termination R-HSA-72764 2.861390e-02 1.543 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 2.863328e-02 1.543 0 0
Gap junction assembly R-HSA-190861 2.863328e-02 1.543 0 0
mRNA Splicing R-HSA-72172 2.874947e-02 1.541 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 3.042967e-02 1.517 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 3.047511e-02 1.516 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 3.070008e-02 1.513 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 3.070008e-02 1.513 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 3.070008e-02 1.513 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 3.141739e-02 1.503 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 3.141739e-02 1.503 0 0
Diseases of Telomere Maintenance R-HSA-9673013 3.141739e-02 1.503 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 3.141739e-02 1.503 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 3.141739e-02 1.503 0 0
CaM pathway R-HSA-111997 3.228412e-02 1.491 0 0
Calmodulin induced events R-HSA-111933 3.228412e-02 1.491 0 0
Circadian clock R-HSA-9909396 3.273311e-02 1.485 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 3.344249e-02 1.476 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 3.364967e-02 1.473 0 0
ABC-family proteins mediated transport R-HSA-382556 3.384695e-02 1.470 0 0
Regulation of KIT signaling R-HSA-1433559 3.406481e-02 1.468 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 3.419638e-02 1.466 0 0
Ovarian tumor domain proteases R-HSA-5689896 3.419638e-02 1.466 0 0
Selenocysteine synthesis R-HSA-2408557 3.496020e-02 1.456 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 4.675539e-02 1.330 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 4.675539e-02 1.330 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 3.756589e-02 1.425 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 4.883654e-02 1.311 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 4.883654e-02 1.311 0 0
Ephrin signaling R-HSA-3928664 5.283299e-02 1.277 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 4.027699e-02 1.395 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 4.027699e-02 1.395 0 0
Viral mRNA Translation R-HSA-192823 3.725408e-02 1.429 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 3.888102e-02 1.410 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 5.251716e-02 1.280 0 0
Attenuation phase R-HSA-3371568 4.027699e-02 1.395 0 0
RNA Polymerase I Transcription R-HSA-73864 5.020080e-02 1.299 0 0
MAP2K and MAPK activation R-HSA-5674135 4.461364e-02 1.351 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 4.686558e-02 1.329 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 4.119818e-02 1.385 0 0
Prolonged ERK activation events R-HSA-169893 4.119818e-02 1.385 0 0
Ca-dependent events R-HSA-111996 4.686558e-02 1.329 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 4.241730e-02 1.372 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 5.005323e-02 1.301 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 3.756589e-02 1.425 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 3.819315e-02 1.418 0 0
S Phase R-HSA-69242 5.181095e-02 1.286 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 3.756589e-02 1.425 0 0
Negative regulation of FLT3 R-HSA-9706369 4.119818e-02 1.385 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 4.468029e-02 1.350 0 0
Signaling by NTRKs R-HSA-166520 5.181095e-02 1.286 0 0
Membrane Trafficking R-HSA-199991 4.143131e-02 1.383 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 4.039831e-02 1.394 0 0
G2/M DNA damage checkpoint R-HSA-69473 4.353280e-02 1.361 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 3.843489e-02 1.415 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 4.686558e-02 1.329 0 0
FCERI mediated NF-kB activation R-HSA-2871837 4.709186e-02 1.327 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 4.039831e-02 1.394 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 5.283299e-02 1.277 0 0
Mitotic Anaphase R-HSA-68882 3.725685e-02 1.429 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 3.803458e-02 1.420 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 3.739702e-02 1.427 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 3.762236e-02 1.425 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 4.552781e-02 1.342 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 3.888102e-02 1.410 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 3.888102e-02 1.410 0 0
Cell-extracellular matrix interactions R-HSA-446353 3.756589e-02 1.425 0 0
Response of Mtb to phagocytosis R-HSA-9637690 4.917263e-02 1.308 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 4.461364e-02 1.351 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 3.848130e-02 1.415 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 4.338551e-02 1.363 0 0
Signaling by ALK in cancer R-HSA-9700206 4.338551e-02 1.363 0 0
PCP/CE pathway R-HSA-4086400 5.020080e-02 1.299 1 1
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 5.373354e-02 1.270 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 5.373354e-02 1.270 0 0
DAG and IP3 signaling R-HSA-1489509 5.395000e-02 1.268 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 5.395000e-02 1.268 0 0
MITF-M-dependent gene expression R-HSA-9856651 5.427508e-02 1.265 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 5.553340e-02 1.255 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 5.641925e-02 1.249 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 5.641925e-02 1.249 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 5.641925e-02 1.249 0 0
Regulation of signaling by CBL R-HSA-912631 5.694139e-02 1.245 0 0
Adaptive Immune System R-HSA-1280218 5.771738e-02 1.239 0 0
DNA Replication R-HSA-69306 5.810263e-02 1.236 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 5.894142e-02 1.230 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 5.894142e-02 1.230 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 5.941358e-02 1.226 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 6.074209e-02 1.217 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 6.115723e-02 1.214 0 0
Negative regulation of MET activity R-HSA-6807004 6.115723e-02 1.214 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 6.115723e-02 1.214 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 6.119310e-02 1.213 0 0
Intraflagellar transport R-HSA-5620924 6.151593e-02 1.211 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 6.185144e-02 1.209 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 6.185144e-02 1.209 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 6.185144e-02 1.209 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 6.185144e-02 1.209 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 6.185144e-02 1.209 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 6.185144e-02 1.209 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 6.185144e-02 1.209 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 6.185144e-02 1.209 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 6.185144e-02 1.209 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 6.185144e-02 1.209 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 6.185144e-02 1.209 0 0
Oncogenic MAPK signaling R-HSA-6802957 6.313941e-02 1.200 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 6.547612e-02 1.184 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 6.547612e-02 1.184 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 6.547612e-02 1.184 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 6.712875e-02 1.173 0 0
Post NMDA receptor activation events R-HSA-438064 6.917146e-02 1.160 0 0
HSF1-dependent transactivation R-HSA-3371571 6.954714e-02 1.158 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 6.989375e-02 1.156 0 0
Attachment and Entry R-HSA-9694614 6.989375e-02 1.156 0 0
Host Interactions of HIV factors R-HSA-162909 7.192206e-02 1.143 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 7.232457e-02 1.141 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 7.232457e-02 1.141 0 0
ER-Phagosome pathway R-HSA-1236974 7.335208e-02 1.135 0 0
Selenoamino acid metabolism R-HSA-2408522 7.348971e-02 1.134 0 0
PLC-gamma1 signalling R-HSA-167021 7.670934e-02 1.115 0 0
Signalling to STAT3 R-HSA-198745 7.670934e-02 1.115 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 7.765833e-02 1.110 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 8.094824e-02 1.092 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 9.133283e-02 1.039 0 0
G2 Phase R-HSA-68911 1.057256e-01 0.976 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 1.057256e-01 0.976 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 1.057256e-01 0.976 0 0
NGF-independant TRKA activation R-HSA-187024 1.198912e-01 0.921 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 1.198912e-01 0.921 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.198912e-01 0.921 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 1.198912e-01 0.921 0 0
Erythropoietin activates STAT5 R-HSA-9027283 1.338334e-01 0.873 0 0
Autointegration results in viral DNA circles R-HSA-177539 1.338334e-01 0.873 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 1.338334e-01 0.873 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.475555e-01 0.831 0 0
Regulation of PTEN localization R-HSA-8948747 1.475555e-01 0.831 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.475555e-01 0.831 0 0
Type I hemidesmosome assembly R-HSA-446107 1.610610e-01 0.793 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 1.610610e-01 0.793 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.345455e-01 0.871 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 8.391751e-02 1.076 0 0
Voltage gated Potassium channels R-HSA-1296072 1.564382e-01 0.806 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 9.624821e-02 1.017 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.059507e-01 0.975 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.059507e-01 0.975 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.160189e-01 0.935 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.408088e-01 0.851 0 0
Centrosome maturation R-HSA-380287 1.481953e-01 0.829 0 0
Signaling by EGFR in Cancer R-HSA-1643713 9.332049e-02 1.030 0 0
Downstream signal transduction R-HSA-186763 1.186324e-01 0.926 0 0
COPI-mediated anterograde transport R-HSA-6807878 9.369432e-02 1.028 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.057256e-01 0.976 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.610610e-01 0.793 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.564382e-01 0.806 0 0
Activation of the pre-replicative complex R-HSA-68962 1.134404e-01 0.945 0 0
Regulation of gap junction activity R-HSA-191650 9.133283e-02 1.039 0 0
Adipogenesis R-HSA-9843745 8.831132e-02 1.054 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.335517e-01 0.874 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 1.057256e-01 0.976 0 0
PTK6 Expression R-HSA-8849473 1.475555e-01 0.831 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 9.133283e-02 1.039 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 9.133283e-02 1.039 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 1.198912e-01 0.921 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.238826e-01 0.907 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.519351e-01 0.818 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 9.824646e-02 1.008 0 0
Signalling to ERKs R-HSA-187687 1.454049e-01 0.837 0 0
Mitotic Prometaphase R-HSA-68877 1.260295e-01 0.900 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 9.133283e-02 1.039 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 1.198912e-01 0.921 0 0
Cam-PDE 1 activation R-HSA-111957 1.198912e-01 0.921 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 1.475555e-01 0.831 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.475555e-01 0.831 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 8.369787e-02 1.077 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.399521e-01 0.854 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.264307e-01 0.898 0 0
eNOS activation R-HSA-203615 1.399521e-01 0.854 0 0
PLC beta mediated events R-HSA-112043 9.944042e-02 1.002 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.085837e-01 0.964 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.083098e-01 0.965 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.291880e-01 0.889 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 8.846974e-02 1.053 0 0
Ca2+ pathway R-HSA-4086398 1.408088e-01 0.851 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 9.133283e-02 1.039 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 1.475555e-01 0.831 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.509012e-01 0.821 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 1.291880e-01 0.889 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.026749e-01 0.989 0 0
Protein ubiquitination R-HSA-8852135 1.481953e-01 0.829 0 0
G-protein mediated events R-HSA-112040 1.194524e-01 0.923 0 0
rRNA processing R-HSA-72312 1.113164e-01 0.953 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 1.620132e-01 0.790 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.134404e-01 0.945 0 0
Cilium Assembly R-HSA-5617833 1.201076e-01 0.920 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 1.338334e-01 0.873 0 0
SLC-mediated bile acid transport R-HSA-9958517 1.610610e-01 0.793 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.137702e-01 0.944 0 0
Oncogene Induced Senescence R-HSA-2559585 1.454049e-01 0.837 0 0
Opioid Signalling R-HSA-111885 1.137702e-01 0.944 0 0
RNA Polymerase II Transcription R-HSA-73857 1.500172e-01 0.824 0 0
Gene expression (Transcription) R-HSA-74160 1.029773e-01 0.987 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 1.057256e-01 0.976 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 1.057256e-01 0.976 0 0
DARPP-32 events R-HSA-180024 1.083098e-01 0.965 0 0
GPVI-mediated activation cascade R-HSA-114604 1.509012e-01 0.821 0 0
Signaling by ERBB2 R-HSA-1227986 9.624821e-02 1.017 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.099134e-02 1.041 0 0
Vesicle-mediated transport R-HSA-5653656 1.167822e-01 0.933 0 0
Organelle biogenesis and maintenance R-HSA-1852241 9.723888e-02 1.012 0 0
Developmental Cell Lineages R-HSA-9734767 8.612914e-02 1.065 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.291880e-01 0.889 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.057256e-01 0.976 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.198912e-01 0.921 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.345455e-01 0.871 0 0
RUNX2 regulates bone development R-HSA-8941326 1.509012e-01 0.821 0 0
RSV-host interactions R-HSA-9833110 1.164040e-01 0.934 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 1.198912e-01 0.921 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 1.291880e-01 0.889 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 1.557047e-01 0.808 0 0
Cardiogenesis R-HSA-9733709 1.291880e-01 0.889 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 9.824646e-02 1.008 0 0
Kinesins R-HSA-983189 9.624821e-02 1.017 0 0
Cellular response to starvation R-HSA-9711097 1.526882e-01 0.816 0 0
Disease R-HSA-1643685 1.289873e-01 0.889 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 1.134404e-01 0.945 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 1.059507e-01 0.975 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 1.092673e-01 0.962 0 0
Signaling by TGFB family members R-HSA-9006936 1.577142e-01 0.802 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 1.633302e-01 0.787 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.999367e-02 1.046 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 1.399521e-01 0.854 0 0
Antigen processing-Cross presentation R-HSA-1236975 1.272013e-01 0.896 0 0
Bacterial Infection Pathways R-HSA-9824439 1.249972e-01 0.903 0 0
Sema4D in semaphorin signaling R-HSA-400685 8.846974e-02 1.053 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 8.896236e-02 1.051 0 0
G1/S-Specific Transcription R-HSA-69205 1.509012e-01 0.821 0 0
Cellular response to chemical stress R-HSA-9711123 9.285483e-02 1.032 0 0
Influenza Infection R-HSA-168255 9.963333e-02 1.002 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 1.240398e-01 0.906 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.671844e-01 0.777 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 1.676237e-01 0.776 0 0
Cellular response to heat stress R-HSA-3371556 1.710984e-01 0.767 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 1.710984e-01 0.767 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.732672e-01 0.761 0 0
Generation of second messenger molecules R-HSA-202433 1.732672e-01 0.761 0 0
Diseases of Immune System R-HSA-5260271 1.732672e-01 0.761 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 1.732672e-01 0.761 0 0
ARMS-mediated activation R-HSA-170984 1.743535e-01 0.759 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.743535e-01 0.759 0 0
Calcineurin activates NFAT R-HSA-2025928 1.743535e-01 0.759 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.743535e-01 0.759 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 1.743535e-01 0.759 0 0
Interleukin-1 processing R-HSA-448706 1.743535e-01 0.759 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.743535e-01 0.759 0 0
Generic Transcription Pathway R-HSA-212436 1.765880e-01 0.753 0 0
MHC class II antigen presentation R-HSA-2132295 1.773141e-01 0.751 0 0
FLT3 Signaling R-HSA-9607240 1.789412e-01 0.747 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.828587e-01 0.738 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 1.874361e-01 0.727 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 1.874361e-01 0.727 0 0
Regulation of CDH11 function R-HSA-9762292 1.874361e-01 0.727 0 0
PI3K/AKT activation R-HSA-198203 1.874361e-01 0.727 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.874361e-01 0.727 0 0
2-LTR circle formation R-HSA-164843 1.874361e-01 0.727 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.874361e-01 0.727 0 0
Josephin domain DUBs R-HSA-5689877 1.874361e-01 0.727 0 0
Neddylation R-HSA-8951664 1.900218e-01 0.721 0 0
Signaling by SCF-KIT R-HSA-1433557 1.961232e-01 0.707 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 2.003121e-01 0.698 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 2.003121e-01 0.698 0 0
Ionotropic activity of kainate receptors R-HSA-451306 2.003121e-01 0.698 0 0
vRNP Assembly R-HSA-192905 2.003121e-01 0.698 0 0
Bicarbonate transporters R-HSA-425381 2.003121e-01 0.698 0 0
Suppression of apoptosis R-HSA-9635465 2.003121e-01 0.698 0 0
Dissolution of Fibrin Clot R-HSA-75205 2.003121e-01 0.698 0 0
G1 Phase R-HSA-69236 2.018963e-01 0.695 0 0
Cyclin D associated events in G1 R-HSA-69231 2.018963e-01 0.695 0 0
HIV Infection R-HSA-162906 2.046142e-01 0.689 0 0
Parasitic Infection Pathways R-HSA-9824443 2.081490e-01 0.682 0 0
Leishmania infection R-HSA-9658195 2.081490e-01 0.682 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.111558e-01 0.675 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 2.129850e-01 0.672 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.129850e-01 0.672 0 0
Integration of provirus R-HSA-162592 2.129850e-01 0.672 0 0
NF-kB is activated and signals survival R-HSA-209560 2.129850e-01 0.672 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 2.129850e-01 0.672 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 2.129850e-01 0.672 0 0
Sodium/Calcium exchangers R-HSA-425561 2.129850e-01 0.672 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 2.129850e-01 0.672 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 2.254578e-01 0.647 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.254578e-01 0.647 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.254578e-01 0.647 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 2.254578e-01 0.647 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 2.254578e-01 0.647 0 0
Scavenging by Class F Receptors R-HSA-3000484 2.254578e-01 0.647 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.254578e-01 0.647 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.254578e-01 0.647 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.254578e-01 0.647 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.254578e-01 0.647 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.254578e-01 0.647 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.254578e-01 0.647 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 2.254578e-01 0.647 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.254578e-01 0.647 0 0
Disorders of Nervous System Development R-HSA-9697154 2.254578e-01 0.647 0 0
Pervasive developmental disorders R-HSA-9005895 2.254578e-01 0.647 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 2.254578e-01 0.647 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.254578e-01 0.647 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 2.310120e-01 0.636 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 2.377336e-01 0.624 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.377336e-01 0.624 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 2.377336e-01 0.624 0 0
Frs2-mediated activation R-HSA-170968 2.377336e-01 0.624 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 2.377336e-01 0.624 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 2.377336e-01 0.624 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 2.377336e-01 0.624 0 0
Formation of axial mesoderm R-HSA-9796292 2.377336e-01 0.624 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 2.377336e-01 0.624 0 0
Maturation of nucleoprotein R-HSA-9683610 2.377336e-01 0.624 0 0
Interleukin-6 signaling R-HSA-1059683 2.377336e-01 0.624 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.445501e-01 0.612 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 2.465504e-01 0.608 0 0
mRNA 3'-end processing R-HSA-72187 2.486129e-01 0.604 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 2.486129e-01 0.604 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 2.486129e-01 0.604 0 0
Retrograde neurotrophin signalling R-HSA-177504 2.498157e-01 0.602 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 2.498157e-01 0.602 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 2.498157e-01 0.602 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 2.498157e-01 0.602 0 0
CRMPs in Sema3A signaling R-HSA-399956 2.498157e-01 0.602 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 2.498157e-01 0.602 0 0
Signal regulatory protein family interactions R-HSA-391160 2.498157e-01 0.602 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 2.530322e-01 0.597 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 2.530322e-01 0.597 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 2.530322e-01 0.597 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 2.544912e-01 0.594 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.544912e-01 0.594 0 0
Disorders of transmembrane transporters R-HSA-5619115 2.558896e-01 0.592 0 0
FOXO-mediated transcription R-HSA-9614085 2.572893e-01 0.590 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 2.603724e-01 0.584 0 0
Chromatin organization R-HSA-4839726 2.612067e-01 0.583 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 2.617070e-01 0.582 0 0
Erythropoietin activates RAS R-HSA-9027284 2.617070e-01 0.582 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 2.617070e-01 0.582 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 2.617070e-01 0.582 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.617070e-01 0.582 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 2.617070e-01 0.582 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 2.617070e-01 0.582 0 0
Spry regulation of FGF signaling R-HSA-1295596 2.617070e-01 0.582 0 0
p75NTR signals via NF-kB R-HSA-193639 2.617070e-01 0.582 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 2.658323e-01 0.575 0 0
HDACs deacetylate histones R-HSA-3214815 2.662550e-01 0.575 0 0
Regulation of endogenous retroelements R-HSA-9842860 2.701167e-01 0.568 0 0
PI Metabolism R-HSA-1483255 2.701167e-01 0.568 0 0
ER to Golgi Anterograde Transport R-HSA-199977 2.708586e-01 0.567 0 0
Signaling by EGFR R-HSA-177929 2.721374e-01 0.565 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.721374e-01 0.565 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 2.734105e-01 0.563 0 0
Activation of SMO R-HSA-5635838 2.734105e-01 0.563 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 2.734105e-01 0.563 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 2.734105e-01 0.563 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 2.734105e-01 0.563 0 0
Attachment and Entry R-HSA-9678110 2.734105e-01 0.563 0 0
Potential therapeutics for SARS R-HSA-9679191 2.814052e-01 0.551 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.838960e-01 0.547 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 2.849292e-01 0.545 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 2.849292e-01 0.545 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 2.849292e-01 0.545 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 2.849292e-01 0.545 0 0
Passive transport by Aquaporins R-HSA-432047 2.849292e-01 0.545 0 0
Disorders of Developmental Biology R-HSA-9675151 2.849292e-01 0.545 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 2.873260e-01 0.542 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 2.897695e-01 0.538 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.962660e-01 0.528 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 2.962660e-01 0.528 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 2.962660e-01 0.528 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 2.962660e-01 0.528 0 0
Choline catabolism R-HSA-6798163 2.962660e-01 0.528 0 0
Uptake and function of anthrax toxins R-HSA-5210891 2.962660e-01 0.528 0 0
Signaling by Hippo R-HSA-2028269 2.962660e-01 0.528 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 3.002898e-01 0.522 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 3.014978e-01 0.521 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 3.046185e-01 0.516 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 3.046185e-01 0.516 0 0
Signaling by PDGF R-HSA-186797 3.073502e-01 0.512 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 3.073502e-01 0.512 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 3.074237e-01 0.512 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 3.074237e-01 0.512 0 0
Platelet sensitization by LDL R-HSA-432142 3.074237e-01 0.512 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 3.074237e-01 0.512 0 0
PKA activation R-HSA-163615 3.074237e-01 0.512 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 3.074237e-01 0.512 0 0
GAB1 signalosome R-HSA-180292 3.074237e-01 0.512 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 3.074237e-01 0.512 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 3.089501e-01 0.510 0 0
MyD88-independent TLR4 cascade R-HSA-166166 3.089501e-01 0.510 0 0
Epigenetic regulation of gene expression R-HSA-212165 3.090163e-01 0.510 0 0
Germ layer formation at gastrulation R-HSA-9754189 3.184052e-01 0.497 0 0
Specification of the neural plate border R-HSA-9834899 3.184052e-01 0.497 0 0
Rap1 signalling R-HSA-392517 3.184052e-01 0.497 0 0
Translesion Synthesis by POLH R-HSA-110320 3.184052e-01 0.497 0 0
E2F mediated regulation of DNA replication R-HSA-113510 3.184052e-01 0.497 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 3.184052e-01 0.497 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 3.184052e-01 0.497 0 0
Other interleukin signaling R-HSA-449836 3.184052e-01 0.497 0 0
Maturation of nucleoprotein R-HSA-9694631 3.184052e-01 0.497 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 3.219554e-01 0.492 0 0
Metabolism of amino acids and derivatives R-HSA-71291 3.240704e-01 0.489 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 3.292133e-01 0.483 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 3.292133e-01 0.483 0 0
Co-inhibition by CTLA4 R-HSA-389513 3.292133e-01 0.483 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 3.292133e-01 0.483 0 0
Formation of definitive endoderm R-HSA-9823730 3.292133e-01 0.483 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 3.292133e-01 0.483 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 3.306537e-01 0.481 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 3.349648e-01 0.475 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 3.392996e-01 0.469 0 0
Signalling to RAS R-HSA-167044 3.398506e-01 0.469 0 0
Early Phase of HIV Life Cycle R-HSA-162594 3.398506e-01 0.469 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 3.398506e-01 0.469 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 3.398506e-01 0.469 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 3.398506e-01 0.469 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 3.422264e-01 0.466 0 0
Regulated Necrosis R-HSA-5218859 3.422264e-01 0.466 0 0
Mitochondrial biogenesis R-HSA-1592230 3.479635e-01 0.458 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 3.503199e-01 0.456 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 3.503199e-01 0.456 0 0
Signaling by PDGFR in disease R-HSA-9671555 3.503199e-01 0.456 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 3.503199e-01 0.456 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 3.503199e-01 0.456 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 3.503199e-01 0.456 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 3.503199e-01 0.456 0 0
Ribavirin ADME R-HSA-9755088 3.503199e-01 0.456 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 3.505199e-01 0.455 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 3.522916e-01 0.453 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 3.566164e-01 0.448 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 3.566164e-01 0.448 0 0
Metabolism of cofactors R-HSA-8978934 3.594642e-01 0.444 0 0
FGFR2 alternative splicing R-HSA-6803529 3.606238e-01 0.443 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 3.606238e-01 0.443 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 3.606238e-01 0.443 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 3.606238e-01 0.443 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 3.606238e-01 0.443 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 3.606238e-01 0.443 0 0
Signaling by KIT in disease R-HSA-9669938 3.606238e-01 0.443 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 3.606238e-01 0.443 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 3.606238e-01 0.443 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 3.651740e-01 0.438 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 3.652544e-01 0.437 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 3.652544e-01 0.437 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 3.695665e-01 0.432 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 3.695665e-01 0.432 0 0
Syndecan interactions R-HSA-3000170 3.707649e-01 0.431 0 0
Growth hormone receptor signaling R-HSA-982772 3.707649e-01 0.431 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.707649e-01 0.431 0 0
Metabolism of proteins R-HSA-392499 3.753589e-01 0.426 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 3.765345e-01 0.424 0 0
Deadenylation of mRNA R-HSA-429947 3.807457e-01 0.419 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 3.807457e-01 0.419 0 0
Neurodegenerative Diseases R-HSA-8863678 3.807457e-01 0.419 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 3.807457e-01 0.419 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 3.807457e-01 0.419 0 0
Mitochondrial RNA degradation R-HSA-9836573 3.807457e-01 0.419 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 3.807457e-01 0.419 0 0
Interleukin-6 family signaling R-HSA-6783589 3.807457e-01 0.419 0 0
Chromatin modifying enzymes R-HSA-3247509 3.817482e-01 0.418 0 0
Long-term potentiation R-HSA-9620244 3.905689e-01 0.408 0 0
TGFBR3 expression R-HSA-9839394 3.905689e-01 0.408 0 0
Tight junction interactions R-HSA-420029 3.905689e-01 0.408 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 3.905689e-01 0.408 0 0
Formation of the nephric duct R-HSA-9830364 3.905689e-01 0.408 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 3.905689e-01 0.408 0 0
ESR-mediated signaling R-HSA-8939211 3.911713e-01 0.408 0 0
Cellular Senescence R-HSA-2559583 3.923738e-01 0.406 0 0
Nuclear Receptor transcription pathway R-HSA-383280 3.989970e-01 0.399 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 3.989970e-01 0.399 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 4.002368e-01 0.398 0 0
Myogenesis R-HSA-525793 4.002368e-01 0.398 0 0
Urea cycle R-HSA-70635 4.002368e-01 0.398 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 4.002368e-01 0.398 0 0
Sensory processing of sound R-HSA-9659379 4.045545e-01 0.393 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 4.097520e-01 0.387 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 4.097520e-01 0.387 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 4.097520e-01 0.387 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 4.097520e-01 0.387 0 0
Cristae formation R-HSA-8949613 4.097520e-01 0.387 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 4.097520e-01 0.387 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 4.097520e-01 0.387 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 4.097520e-01 0.387 0 0
Signaling by FGFR2 R-HSA-5654738 4.100875e-01 0.387 0 0
Signaling by MET R-HSA-6806834 4.100875e-01 0.387 0 0
Signaling by Nuclear Receptors R-HSA-9006931 4.119862e-01 0.385 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 4.155954e-01 0.381 0 0
HIV elongation arrest and recovery R-HSA-167287 4.191167e-01 0.378 0 0
Pausing and recovery of HIV elongation R-HSA-167290 4.191167e-01 0.378 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 4.191167e-01 0.378 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 4.191167e-01 0.378 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 4.191167e-01 0.378 0 0
Telomere Extension By Telomerase R-HSA-171319 4.191167e-01 0.378 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 4.191167e-01 0.378 0 0
Pyroptosis R-HSA-5620971 4.191167e-01 0.378 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 4.207828e-01 0.376 0 0
Cytoprotection by HMOX1 R-HSA-9707564 4.265332e-01 0.370 0 0
Signaling by Erythropoietin R-HSA-9006335 4.283335e-01 0.368 0 0
Late endosomal microautophagy R-HSA-9615710 4.283335e-01 0.368 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 4.283335e-01 0.368 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 4.283335e-01 0.368 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 4.283335e-01 0.368 0 0
Platelet calcium homeostasis R-HSA-418360 4.283335e-01 0.368 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 4.319621e-01 0.365 0 0
Post-translational protein modification R-HSA-597592 4.338103e-01 0.363 0 0
DAP12 signaling R-HSA-2424491 4.374046e-01 0.359 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 4.374046e-01 0.359 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 4.374046e-01 0.359 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 4.374046e-01 0.359 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 4.374046e-01 0.359 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 4.374046e-01 0.359 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 4.374046e-01 0.359 0 0
Estrogen-dependent gene expression R-HSA-9018519 4.417309e-01 0.355 0 0
EGFR downregulation R-HSA-182971 4.463323e-01 0.350 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 4.463323e-01 0.350 0 0
XBP1(S) activates chaperone genes R-HSA-381038 4.480826e-01 0.349 0 0
HS-GAG degradation R-HSA-2024096 4.551188e-01 0.342 0 0
Signaling by WNT in cancer R-HSA-4791275 4.551188e-01 0.342 0 0
G0 and Early G1 R-HSA-1538133 4.551188e-01 0.342 0 0
Parasite infection R-HSA-9664407 4.582780e-01 0.339 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 4.582780e-01 0.339 0 0
Leishmania phagocytosis R-HSA-9664417 4.582780e-01 0.339 0 0
Diseases of programmed cell death R-HSA-9645723 4.586863e-01 0.338 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.630599e-01 0.334 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 4.637665e-01 0.334 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 4.637665e-01 0.334 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 4.637665e-01 0.334 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 4.637665e-01 0.334 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 4.637665e-01 0.334 0 0
Integrin signaling R-HSA-354192 4.637665e-01 0.334 0 0
Regulation of necroptotic cell death R-HSA-5675482 4.637665e-01 0.334 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 4.637665e-01 0.334 0 0
Interferon Signaling R-HSA-913531 4.661275e-01 0.331 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 4.699873e-01 0.328 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 4.705517e-01 0.327 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 4.722774e-01 0.326 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 4.722774e-01 0.326 0 0
Effects of PIP2 hydrolysis R-HSA-114508 4.722774e-01 0.326 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 4.722774e-01 0.326 0 0
Heme degradation R-HSA-189483 4.722774e-01 0.326 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 4.743687e-01 0.324 0 0
IRE1alpha activates chaperones R-HSA-381070 4.795351e-01 0.319 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 4.806538e-01 0.318 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 4.806538e-01 0.318 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 4.806538e-01 0.318 0 0
RAF activation R-HSA-5673000 4.806538e-01 0.318 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 4.806538e-01 0.318 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 4.806538e-01 0.318 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 4.897744e-01 0.310 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 4.947150e-01 0.306 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 4.970113e-01 0.304 0 0
HS-GAG biosynthesis R-HSA-2022928 4.970113e-01 0.304 0 0
RNA Polymerase III Transcription R-HSA-74158 4.970113e-01 0.304 0 0
RET signaling R-HSA-8853659 4.970113e-01 0.304 0 0
FLT3 signaling in disease R-HSA-9682385 4.970113e-01 0.304 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 4.970113e-01 0.304 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 5.049965e-01 0.297 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 5.074664e-01 0.295 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 5.098706e-01 0.293 0 0
Potassium Channels R-HSA-1296071 5.098706e-01 0.293 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 5.105174e-01 0.292 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 5.128555e-01 0.290 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 5.128555e-01 0.290 0 0
Telomere Maintenance R-HSA-157579 5.148134e-01 0.288 0 0
Signaling by FGFR R-HSA-190236 5.197234e-01 0.284 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 5.205902e-01 0.284 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 5.205902e-01 0.284 0 0
RAS processing R-HSA-9648002 5.205902e-01 0.284 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 5.205902e-01 0.284 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 5.205902e-01 0.284 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 5.205902e-01 0.284 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 5.246002e-01 0.280 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 5.282025e-01 0.277 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 5.282025e-01 0.277 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 5.282025e-01 0.277 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 5.282025e-01 0.277 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 5.282025e-01 0.277 0 0
HIV Transcription Elongation R-HSA-167169 5.282025e-01 0.277 0 0
Glycogen metabolism R-HSA-8982491 5.282025e-01 0.277 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 5.287569e-01 0.277 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 5.356945e-01 0.271 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 5.356945e-01 0.271 0 0
PKMTs methylate histone lysines R-HSA-3214841 5.356945e-01 0.271 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 5.390301e-01 0.268 0 0
Intra-Golgi traffic R-HSA-6811438 5.430679e-01 0.265 0 0
Translation of Structural Proteins R-HSA-9683701 5.430679e-01 0.265 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 5.503247e-01 0.259 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 5.503247e-01 0.259 0 0
Signaling by FGFR4 R-HSA-5654743 5.574666e-01 0.254 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 5.574666e-01 0.254 0 0
Nucleotide Excision Repair R-HSA-5696398 5.577967e-01 0.254 0 0
Platelet homeostasis R-HSA-418346 5.624030e-01 0.250 0 0
DAP12 interactions R-HSA-2172127 5.644956e-01 0.248 0 0
Surfactant metabolism R-HSA-5683826 5.644956e-01 0.248 0 0
RMTs methylate histone arginines R-HSA-3214858 5.644956e-01 0.248 0 0
Gene Silencing by RNA R-HSA-211000 5.669749e-01 0.246 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 5.714133e-01 0.243 0 0
Signaling by FGFR3 R-HSA-5654741 5.714133e-01 0.243 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 5.714133e-01 0.243 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 5.714133e-01 0.243 0 0
Signaling by TGFBR3 R-HSA-9839373 5.782216e-01 0.238 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 5.782216e-01 0.238 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 5.782216e-01 0.238 0 0
Synthesis of PC R-HSA-1483191 5.849222e-01 0.233 0 0
Cell surface interactions at the vascular wall R-HSA-202733 5.878215e-01 0.231 0 0
FCERI mediated MAPK activation R-HSA-2871796 5.893180e-01 0.230 0 0
Inositol phosphate metabolism R-HSA-1483249 5.893180e-01 0.230 0 0
Co-stimulation by CD28 R-HSA-389356 5.915167e-01 0.228 0 0
Metal ion SLC transporters R-HSA-425410 5.915167e-01 0.228 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 5.936829e-01 0.226 0 0
DNA Damage Bypass R-HSA-73893 5.980068e-01 0.223 0 0
Chemokine receptors bind chemokines R-HSA-380108 5.980068e-01 0.223 0 0
Azathioprine ADME R-HSA-9748787 6.043942e-01 0.219 0 0
The phototransduction cascade R-HSA-2514856 6.106805e-01 0.214 0 0
Meiotic recombination R-HSA-912446 6.106805e-01 0.214 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 6.168673e-01 0.210 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 6.168673e-01 0.210 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 6.260270e-01 0.203 0 0
Mitotic Prophase R-HSA-68875 6.314116e-01 0.200 0 0
G alpha (z) signalling events R-HSA-418597 6.348463e-01 0.197 0 0
Chromosome Maintenance R-HSA-73886 6.354314e-01 0.197 0 0
Peptide ligand-binding receptors R-HSA-375276 6.365233e-01 0.196 0 0
Ion homeostasis R-HSA-5578775 6.406505e-01 0.193 0 0
NRAGE signals death through JNK R-HSA-193648 6.406505e-01 0.193 0 0
Signaling by FGFR1 R-HSA-5654736 6.406505e-01 0.193 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 6.433682e-01 0.192 0 0
Nuclear Envelope Breakdown R-HSA-2980766 6.463628e-01 0.190 0 0
Dectin-2 family R-HSA-5621480 6.463628e-01 0.190 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 6.519846e-01 0.186 0 0
Toll-like Receptor Cascades R-HSA-168898 6.525663e-01 0.185 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 6.575175e-01 0.182 0 0
Metabolism of non-coding RNA R-HSA-194441 6.575175e-01 0.182 0 0
snRNP Assembly R-HSA-191859 6.575175e-01 0.182 0 0
Extension of Telomeres R-HSA-180786 6.575175e-01 0.182 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 6.575175e-01 0.182 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 6.575175e-01 0.182 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 6.588331e-01 0.181 0 0
tRNA Aminoacylation R-HSA-379724 6.629626e-01 0.179 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 6.629626e-01 0.179 0 0
Neuronal System R-HSA-112316 6.657146e-01 0.177 0 0
HCMV Early Events R-HSA-9609690 6.680997e-01 0.175 0 0
Aquaporin-mediated transport R-HSA-445717 6.683216e-01 0.175 0 0
Collagen degradation R-HSA-1442490 6.683216e-01 0.175 0 0
tRNA processing in the nucleus R-HSA-6784531 6.735957e-01 0.172 0 0
Mitochondrial protein import R-HSA-1268020 6.735957e-01 0.172 0 0
Heme signaling R-HSA-9707616 6.735957e-01 0.172 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 6.735957e-01 0.172 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 6.737583e-01 0.171 0 0
Complex I biogenesis R-HSA-6799198 6.787862e-01 0.168 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 6.787862e-01 0.168 0 0
G alpha (i) signalling events R-HSA-418594 6.804630e-01 0.167 0 0
CD22 mediated BCR regulation R-HSA-5690714 6.838945e-01 0.165 0 0
Ion transport by P-type ATPases R-HSA-936837 6.838945e-01 0.165 0 0
Infection with Enterobacteria R-HSA-9640148 6.889890e-01 0.162 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 6.938696e-01 0.159 0 0
Kidney development R-HSA-9830369 6.987389e-01 0.156 0 0
DNA Double Strand Break Response R-HSA-5693606 6.987389e-01 0.156 0 0
Integration of energy metabolism R-HSA-163685 7.020197e-01 0.154 0 0
Transcription of the HIV genome R-HSA-167172 7.035311e-01 0.153 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 7.035311e-01 0.153 0 0
Asparagine N-linked glycosylation R-HSA-446203 7.117794e-01 0.148 0 0
Unfolded Protein Response (UPR) R-HSA-381119 7.120831e-01 0.147 0 0
COPII-mediated vesicle transport R-HSA-204005 7.128889e-01 0.147 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 7.128889e-01 0.147 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 7.128889e-01 0.147 0 0
Retinoid metabolism and transport R-HSA-975634 7.174568e-01 0.144 0 0
Metabolism of porphyrins R-HSA-189445 7.174568e-01 0.144 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 7.263766e-01 0.139 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 7.263766e-01 0.139 0 0
DNA Repair R-HSA-73894 7.267397e-01 0.139 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 7.350159e-01 0.134 0 0
ISG15 antiviral mechanism R-HSA-1169408 7.350159e-01 0.134 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 7.350159e-01 0.134 0 0
Iron uptake and transport R-HSA-917937 7.350159e-01 0.134 0 0
Visual phototransduction R-HSA-2187338 7.405811e-01 0.130 0 0
Phospholipid metabolism R-HSA-1483257 7.415670e-01 0.130 0 0
Translation of Structural Proteins R-HSA-9694635 7.433835e-01 0.129 0 0
G alpha (12/13) signalling events R-HSA-416482 7.474680e-01 0.126 0 0
SLC-mediated transport of organic anions R-HSA-9955298 7.474680e-01 0.126 0 0
Integrin cell surface interactions R-HSA-216083 7.474680e-01 0.126 0 0
Protein localization R-HSA-9609507 7.582174e-01 0.120 0 0
DNA Double-Strand Break Repair R-HSA-5693532 7.582174e-01 0.120 0 0
Amyloid fiber formation R-HSA-977225 7.593372e-01 0.120 0 0
Processing of DNA double-strand break ends R-HSA-5693607 7.593372e-01 0.120 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 7.593372e-01 0.120 0 0
Death Receptor Signaling R-HSA-73887 7.610543e-01 0.119 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 7.631687e-01 0.117 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 7.631687e-01 0.117 0 0
PPARA activates gene expression R-HSA-1989781 7.638625e-01 0.117 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 7.693932e-01 0.114 0 0
HIV Life Cycle R-HSA-162587 7.693932e-01 0.114 0 0
Meiosis R-HSA-1500620 7.743026e-01 0.111 0 0
Protein-protein interactions at synapses R-HSA-6794362 7.743026e-01 0.111 0 0
Transmission across Chemical Synapses R-HSA-112315 7.984066e-01 0.098 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 8.046716e-01 0.094 0 0
tRNA processing R-HSA-72306 8.050421e-01 0.094 0 0
HCMV Infection R-HSA-9609646 8.062197e-01 0.094 0 0
FCGR activation R-HSA-2029481 8.077839e-01 0.093 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 8.108468e-01 0.091 0 0
Collagen formation R-HSA-1474290 8.108468e-01 0.091 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 8.120156e-01 0.090 0 0
Leishmania parasite growth and survival R-HSA-9664433 8.120156e-01 0.090 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 8.197469e-01 0.086 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 8.226198e-01 0.085 0 0
Respiratory electron transport R-HSA-611105 8.231460e-01 0.085 0 0
Post-translational protein phosphorylation R-HSA-8957275 8.254472e-01 0.083 0 0
HATs acetylate histones R-HSA-3214847 8.282297e-01 0.082 0 0
G alpha (q) signalling events R-HSA-416476 8.325333e-01 0.080 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 8.363148e-01 0.078 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 8.440208e-01 0.074 0 0
Stimuli-sensing channels R-HSA-2672351 8.537361e-01 0.069 0 0
Metabolism of vitamins and cofactors R-HSA-196854 8.630442e-01 0.064 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 8.671903e-01 0.062 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 8.693096e-01 0.061 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 8.734477e-01 0.059 0 0
Peptide hormone metabolism R-HSA-2980736 8.774553e-01 0.057 0 0
Homology Directed Repair R-HSA-5693538 8.794114e-01 0.056 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 8.887351e-01 0.051 0 0
Formation of the cornified envelope R-HSA-6809371 8.905118e-01 0.050 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 8.939809e-01 0.049 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 8.939809e-01 0.049 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 8.939809e-01 0.049 0 0
Reproduction R-HSA-1474165 9.037448e-01 0.044 0 0
Cardiac conduction R-HSA-5576891 9.052827e-01 0.043 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.067961e-01 0.042 0 0
Metabolism of steroids R-HSA-8957322 9.133382e-01 0.039 0 0
Metabolism of nucleotides R-HSA-15869 9.161894e-01 0.038 0 0
Late Phase of HIV Life Cycle R-HSA-162599 9.231832e-01 0.035 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.324795e-01 0.030 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 9.366984e-01 0.028 0 0
GPCR downstream signalling R-HSA-388396 9.411006e-01 0.026 0 0
Interferon gamma signaling R-HSA-877300 9.416045e-01 0.026 0 0
SLC transporter disorders R-HSA-5619102 9.486786e-01 0.023 0 0
G alpha (s) signalling events R-HSA-418555 9.526593e-01 0.021 0 0
Transport of small molecules R-HSA-382551 9.611543e-01 0.017 0 0
Diseases of glycosylation R-HSA-3781865 9.616279e-01 0.017 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.624480e-01 0.017 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.637927e-01 0.016 0 0
Ion channel transport R-HSA-983712 9.646075e-01 0.016 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.668243e-01 0.015 0 0
Sphingolipid metabolism R-HSA-428157 9.708515e-01 0.013 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.717798e-01 0.012 0 0
Signaling by GPCR R-HSA-372790 9.718689e-01 0.012 0 0
Keratinization R-HSA-6805567 9.735489e-01 0.012 0 0
Drug ADME R-HSA-9748784 9.782202e-01 0.010 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.796860e-01 0.009 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.817762e-01 0.008 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.820692e-01 0.008 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.917749e-01 0.004 0 0
GPCR ligand binding R-HSA-500792 9.969593e-01 0.001 0 0
Fatty acid metabolism R-HSA-8978868 9.990153e-01 0.000 0 0
Diseases of metabolism R-HSA-5668914 9.992908e-01 0.000 0 0
Biological oxidations R-HSA-211859 9.998540e-01 0.000 0 0
Metabolism of lipids R-HSA-556833 9.999185e-01 0.000 0 0
Metabolism R-HSA-1430728 9.999345e-01 0.000 0 0
Sensory Perception R-HSA-9709957 9.999984e-01 0.000 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 1.000000e+00 0.000 1 1
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways