ROR1

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
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Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
O60220 S94 Sugiyama TIMM8A DDP DDP1 TIM8A SQFILNRLEQTQKSKPVFSEsLsD_________________
O60841 S196 Sugiyama EIF5B IF2 KIAA0741 ERsRINssGEsGDEsDEFLQsRKGQKKNQKNKPGPNIEsGN
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P08238 Y301 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB ELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHF
P08238 Y305 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB tKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEG
P18615 S113 Sugiyama NELFE RD RDBP EGKLKDPEKGPVPTFQPFQRsIsADDDLQEsSRRPQRKsLy
P18615 S135 Sugiyama NELFE RD RDBP sADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGEEAEG
P21860 Y1307 PSP ERBB3 HER3 QGyEEMRAFQGPGHQAPHVHyARLKTLRsLEATDSAFDNPD
P26373 T148 Sugiyama RPL13 BBC1 OK/SW-cl.46 PRKPSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARV
P26373 T151 Sugiyama RPL13 BBC1 OK/SW-cl.46 PSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARVItE
P27797 S52 Sugiyama CALR CRTC GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P27797 S53 Sugiyama CALR CRTC WtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDAR
P29692 S64 Sugiyama EEF1D EF1D sVILRDIARARENIQKsLAGssGPGAssGtsGDHGELVVRI
P35579 T1208 Sugiyama MYH9 QEMRQKHsQAVEELAEQLEQtKRVKANLEKAKQtLENERGE
P51813 Y90 Sugiyama BMX EQtPVERQyPFQIVyKDGLLyVyASNEESRSQWLKALQKEI
P51813 Y92 Sugiyama BMX tPVERQyPFQIVyKDGLLyVyASNEESRSQWLKALQKEIRG
P51957 S639 Sugiyama NEK4 STK2 RRLKQsQEEMSSsGPSVRKAsLsVAGPGKPQEEDQPLPARR
P51957 S641 Sugiyama NEK4 STK2 LKQsQEEMSSsGPSVRKAsLsVAGPGKPQEEDQPLPARRLs
P60709 T318 Sugiyama ACTB VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P60709 T324 Sugiyama ACTB tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P61254 T8 Sugiyama RPL26 _____________MKFNPFVtsDRsKNRKRHFNAPsHIRRK
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62736 T320 Sugiyama ACTA2 ACTSA ACTVS GIG46 VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P62736 T326 Sugiyama ACTA2 ACTSA ACTVS GIG46 TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62899 T119 Sugiyama RPL31 PNKLytLVtyVPVttFKNLQtVNVDEN______________
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917 Y133 Sugiyama RPL8 VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P62979 S134 Sugiyama RPS27A UBA80 UBCEP1 IsRLRRECPsDECGAGVFMAsHFDRHyCGKCCLtyCFNKPE
P63261 T318 Sugiyama ACTG1 ACTG VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P63261 T324 Sugiyama ACTG1 ACTG tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63267 T319 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P63267 T325 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68032 T320 Sugiyama ACTC1 ACTC VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68032 T326 Sugiyama ACTC1 ACTC TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68133 T320 Sugiyama ACTA1 ACTA VMSGGTTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68133 T326 Sugiyama ACTA1 ACTA TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68363 Y432 Sugiyama TUBA1B GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q01973 S642 Sugiyama ROR1 NTRKR1 LIGEQLHVKISDLGLSREIYsADYYRVQSKSLLPIRWMPPE
Q15080 S67 Sugiyama NCF4 SH3PXD4 TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q71U36 Y432 Sugiyama TUBA1A TUBA3 GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q7Z2W4 T273 Sugiyama ZC3HAV1 ZC3HDC2 PRO1677 FFQGsQEFLASASAsAERsCtPsPDQIsHRAsLEDAPVDDL
Q8IZ21 S118 Sugiyama PHACTR4 PRO2963 PSDAMLKNGHTTPIGNARsssPVQVEEEPVRLAsLRKAIPE
Q9BXS6 S363 Sugiyama NUSAP1 ANKT BM-037 PRO0310 TtEAtQtPVsNKKPVFDLKAsLsRPLNyEPHKGKLKPWGQS
Q9UNX3 T8 Sugiyama RPL26L1 RPL26P1 _____________MKFNPFVtsDRsKNRKRHFNAPSHVRRK
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Axon guidance R-HSA-422475 4.158053e-07 6.381 0 0
Nervous system development R-HSA-9675108 5.668331e-07 6.247 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.338990e-06 5.873 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.807494e-06 5.743 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 3.430860e-06 5.465 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 3.977277e-06 5.400 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.109050e-05 4.955 0 0
Signaling by ERBB2 R-HSA-1227986 3.037051e-05 4.518 0 0
Cell-Cell communication R-HSA-1500931 2.879899e-05 4.541 0 0
Signaling by ERBB4 R-HSA-1236394 8.092320e-05 4.092 0 0
Regulation of PTEN localization R-HSA-8948747 8.116597e-05 4.091 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 9.077941e-05 4.042 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.337184e-04 3.874 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.337184e-04 3.874 0 0
EPH-Ephrin signaling R-HSA-2682334 1.260366e-04 3.900 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.492736e-04 3.826 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.492736e-04 3.826 0 0
FLT3 Signaling R-HSA-9607240 1.667817e-04 3.778 0 0
Regulation of CDH1 Function R-HSA-9764561 2.278037e-04 3.642 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.207740e-04 3.656 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.383311e-04 3.623 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 2.651450e-04 3.577 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 3.180118e-04 3.498 0 0
Signaling by ALK in cancer R-HSA-9700206 3.180118e-04 3.498 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 3.836291e-04 3.416 0 0
PECAM1 interactions R-HSA-210990 4.850382e-04 3.314 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 5.499894e-04 3.260 0 0
Semaphorin interactions R-HSA-373755 5.403394e-04 3.267 0 0
Signaling by PTK6 R-HSA-8848021 5.403394e-04 3.267 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 5.403394e-04 3.267 0 0
Apoptotic execution phase R-HSA-75153 4.738792e-04 3.324 0 0
Cell junction organization R-HSA-446728 5.808550e-04 3.236 0 0
MTF1 activates gene expression R-HSA-5660489 8.682295e-04 3.061 0 0
Late endosomal microautophagy R-HSA-9615710 8.673319e-04 3.062 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 8.540664e-04 3.069 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 8.371267e-04 3.077 0 0
UCH proteinases R-HSA-5689603 9.415236e-04 3.026 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 9.689180e-04 3.014 0 0
VLDLR internalisation and degradation R-HSA-8866427 9.632805e-04 3.016 0 0
p75NTR recruits signalling complexes R-HSA-209543 9.632805e-04 3.016 0 0
Syndecan interactions R-HSA-3000170 1.065760e-03 2.972 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 1.016756e-03 2.993 0 0
Cell Cycle R-HSA-1640170 1.125548e-03 2.949 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.183578e-03 2.927 0 0
Budding and maturation of HIV virion R-HSA-162588 1.268675e-03 2.897 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 1.308556e-03 2.883 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 1.317403e-03 2.880 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.413086e-03 2.850 0 0
Signal Transduction R-HSA-162582 1.419321e-03 2.848 1 0
Cell-cell junction organization R-HSA-421270 1.520346e-03 2.818 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 1.523919e-03 2.817 0 0
Regulation of KIT signaling R-HSA-1433559 1.741150e-03 2.759 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 1.741150e-03 2.759 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.691285e-03 2.772 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 1.864995e-03 2.729 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.829406e-03 2.738 0 0
Metalloprotease DUBs R-HSA-5689901 1.961427e-03 2.707 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.043127e-03 2.690 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.066753e-03 2.685 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 2.458714e-03 2.609 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 2.458714e-03 2.609 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.138868e-03 2.670 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 2.372055e-03 2.625 0 0
Eukaryotic Translation Elongation R-HSA-156842 2.383161e-03 2.623 0 0
Josephin domain DUBs R-HSA-5689877 2.269825e-03 2.644 0 0
p75NTR signals via NF-kB R-HSA-193639 2.274373e-03 2.643 0 0
Pexophagy R-HSA-9664873 2.269825e-03 2.644 0 0
Programmed Cell Death R-HSA-5357801 2.466001e-03 2.608 0 0
Maturation of protein E R-HSA-9694493 2.463359e-03 2.608 0 0
Maturation of protein E R-HSA-9683683 2.463359e-03 2.608 0 0
DNA Double Strand Break Response R-HSA-5693606 2.568047e-03 2.590 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.711078e-03 2.567 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 2.824621e-03 2.549 0 0
Negative regulation of FLT3 R-HSA-9706369 2.922106e-03 2.534 0 0
Cell Cycle, Mitotic R-HSA-69278 2.987516e-03 2.525 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 3.021173e-03 2.520 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 3.109560e-03 2.507 0 0
Cellular responses to stimuli R-HSA-8953897 3.335281e-03 2.477 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 3.365496e-03 2.473 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 3.518457e-03 2.454 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 3.365496e-03 2.473 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 3.429056e-03 2.465 0 0
Cellular Senescence R-HSA-2559583 3.617217e-03 2.442 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 3.776186e-03 2.423 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 3.975171e-03 2.401 0 0
Smooth Muscle Contraction R-HSA-445355 3.972328e-03 2.401 0 0
Signaling by ROBO receptors R-HSA-376176 3.931533e-03 2.405 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 4.152834e-03 2.382 0 0
NF-kB is activated and signals survival R-HSA-209560 4.152834e-03 2.382 0 0
Translation initiation complex formation R-HSA-72649 4.471699e-03 2.350 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 4.356939e-03 2.361 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 4.560112e-03 2.341 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 4.560112e-03 2.341 0 0
Signaling by Hippo R-HSA-2028269 4.618668e-03 2.335 0 0
L1CAM interactions R-HSA-373760 4.830840e-03 2.316 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 5.307273e-03 2.275 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 5.219739e-03 2.282 0 0
Adherens junctions interactions R-HSA-418990 5.206692e-03 2.283 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 5.424557e-03 2.266 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 5.424557e-03 2.266 0 0
Recycling pathway of L1 R-HSA-437239 5.553421e-03 2.255 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 5.845139e-03 2.233 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 5.566372e-03 2.254 0 0
Iron uptake and transport R-HSA-917937 5.878331e-03 2.231 0 0
NRAGE signals death through JNK R-HSA-193648 5.619461e-03 2.250 0 0
Oncogenic MAPK signaling R-HSA-6802957 6.090696e-03 2.215 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 6.949161e-03 2.158 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 8.750271e-03 2.058 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 6.948098e-03 2.158 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 8.695720e-03 2.061 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 6.987571e-03 2.156 0 0
Nuclear Receptor transcription pathway R-HSA-383280 7.767174e-03 2.110 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 7.306563e-03 2.136 0 0
Ribosome-associated quality control R-HSA-9948299 6.540807e-03 2.184 0 0
Signaling by EGFR in Cancer R-HSA-1643713 7.427278e-03 2.129 0 0
mRNA Splicing - Major Pathway R-HSA-72163 8.178656e-03 2.087 0 0
Translesion Synthesis by POLH R-HSA-110320 6.948098e-03 2.158 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 8.750271e-03 2.058 0 0
Peptide chain elongation R-HSA-156902 8.596240e-03 2.066 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 8.616087e-03 2.065 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 7.496991e-03 2.125 0 0
G alpha (12/13) signalling events R-HSA-416482 7.767174e-03 2.110 0 0
HIV Infection R-HSA-162906 8.323724e-03 2.080 0 0
Chromatin organization R-HSA-4839726 8.025550e-03 2.096 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 7.496991e-03 2.125 0 0
Chromatin modifying enzymes R-HSA-3247509 6.701540e-03 2.174 0 0
NRIF signals cell death from the nucleus R-HSA-205043 8.750271e-03 2.058 0 0
Regulation of signaling by CBL R-HSA-912631 6.948098e-03 2.158 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 8.750271e-03 2.058 0 0
Apoptosis R-HSA-109581 8.177930e-03 2.087 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 7.474607e-03 2.126 0 0
Modulation by Mtb of host immune system R-HSA-9637628 7.496991e-03 2.125 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 7.496991e-03 2.125 0 0
Gene expression (Transcription) R-HSA-74160 8.783662e-03 2.056 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 8.795419e-03 2.056 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 9.108133e-03 2.041 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.002797e-02 1.999 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 1.006648e-02 1.997 0 0
Signaling by FGFR2 R-HSA-5654738 9.271897e-03 2.033 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.006648e-02 1.997 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.085042e-02 1.965 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 1.085042e-02 1.965 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.085042e-02 1.965 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.085042e-02 1.965 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.085042e-02 1.965 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 1.092839e-02 1.961 0 0
DCC mediated attractive signaling R-HSA-418885 1.085042e-02 1.965 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.112316e-02 1.954 0 0
Translesion synthesis by REV1 R-HSA-110312 1.085042e-02 1.965 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.085042e-02 1.965 0 0
Metabolism of RNA R-HSA-8953854 1.138774e-02 1.944 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.085827e-02 1.964 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.153503e-02 1.938 0 0
Signaling by PDGFR in disease R-HSA-9671555 1.188510e-02 1.925 0 0
Assembly Of The HIV Virion R-HSA-175474 1.188510e-02 1.925 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.238834e-02 1.907 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.238834e-02 1.907 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.244673e-02 1.905 0 0
Fanconi Anemia Pathway R-HSA-6783310 1.244673e-02 1.905 0 0
Translesion synthesis by POLI R-HSA-5656121 1.327080e-02 1.877 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.327080e-02 1.877 0 0
FGFR2 alternative splicing R-HSA-6803529 1.397192e-02 1.855 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 1.388407e-02 1.857 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.392890e-02 1.856 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.392890e-02 1.856 0 0
mRNA Splicing R-HSA-72172 1.441394e-02 1.841 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.295858e-02 1.887 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 1.314692e-02 1.881 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.409137e-02 1.851 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.380633e-02 1.860 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.345250e-02 1.871 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 1.397192e-02 1.855 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.477493e-02 1.830 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.477493e-02 1.830 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 1.538761e-02 1.813 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.538761e-02 1.813 0 0
MAPK family signaling cascades R-HSA-5683057 1.558823e-02 1.807 0 0
RNA Polymerase II Transcription R-HSA-73857 1.591984e-02 1.798 0 0
Translesion synthesis by POLK R-HSA-5655862 1.603103e-02 1.795 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 1.603103e-02 1.795 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 1.603103e-02 1.795 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 1.639528e-02 1.785 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.672269e-02 1.777 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 1.676961e-02 1.775 0 0
NGF-stimulated transcription R-HSA-9031628 1.712163e-02 1.766 0 0
Protein localization R-HSA-9609507 1.721723e-02 1.764 0 0
G2/M Transition R-HSA-69275 1.738572e-02 1.760 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.751232e-02 1.757 0 0
Aggrephagy R-HSA-9646399 1.763303e-02 1.754 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 2.025380e-02 1.693 0 0
Integrin signaling R-HSA-354192 1.983560e-02 1.703 0 0
Regulation of necroptotic cell death R-HSA-5675482 1.983560e-02 1.703 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.918136e-02 1.717 0 0
Regulated Necrosis R-HSA-5218859 1.809846e-02 1.742 0 0
Sensory processing of sound R-HSA-9659379 1.948180e-02 1.710 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.087458e-02 1.680 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 2.096035e-02 1.679 0 0
Cellular responses to stress R-HSA-2262752 2.132845e-02 1.671 0 0
HIV Life Cycle R-HSA-162587 2.132944e-02 1.671 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 2.136825e-02 1.670 0 0
Kinesins R-HSA-983189 2.136825e-02 1.670 0 0
MAP2K and MAPK activation R-HSA-5674135 2.191292e-02 1.659 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 2.198563e-02 1.658 0 0
Striated Muscle Contraction R-HSA-390522 2.236575e-02 1.650 0 0
DNA Replication Pre-Initiation R-HSA-69002 2.301954e-02 1.638 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 2.652023e-02 1.576 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.652023e-02 1.576 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 2.430705e-02 1.614 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 2.519411e-02 1.599 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 2.360456e-02 1.627 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 2.511060e-02 1.600 0 0
PTEN Regulation R-HSA-6807070 2.570197e-02 1.590 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.440168e-02 1.613 0 0
Nef and signal transduction R-HSA-164944 2.502116e-02 1.602 0 0
Switching of origins to a post-replicative state R-HSA-69052 2.707077e-02 1.567 0 0
DNA Repair R-HSA-73894 2.471824e-02 1.607 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.443721e-02 1.612 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 2.330612e-02 1.633 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 2.573948e-02 1.589 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 2.573948e-02 1.589 0 0
IRAK1 recruits IKK complex R-HSA-937039 2.573948e-02 1.589 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 2.573948e-02 1.589 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 3.157441e-02 1.501 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 3.157441e-02 1.501 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 3.157441e-02 1.501 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 3.157441e-02 1.501 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 3.157441e-02 1.501 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 3.157441e-02 1.501 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 3.157441e-02 1.501 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 3.157441e-02 1.501 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 3.157441e-02 1.501 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 3.157441e-02 1.501 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 3.157441e-02 1.501 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 3.157441e-02 1.501 0 0
CD28 dependent Vav1 pathway R-HSA-389359 3.112189e-02 1.507 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 3.079942e-02 1.511 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.827831e-02 1.549 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.827831e-02 1.549 0 0
HIV elongation arrest and recovery R-HSA-167287 3.198775e-02 1.495 0 0
Pausing and recovery of HIV elongation R-HSA-167290 3.198775e-02 1.495 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 2.807748e-02 1.552 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.757381e-02 1.560 0 0
Protein ubiquitination R-HSA-8852135 3.143193e-02 1.503 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.871870e-02 1.542 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 3.112189e-02 1.507 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 2.807748e-02 1.552 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 3.198775e-02 1.495 0 0
Regulation of Apoptosis R-HSA-169911 2.807748e-02 1.552 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 2.821798e-02 1.549 0 0
Late Phase of HIV Life Cycle R-HSA-162599 3.169768e-02 1.499 0 0
Cyclin D associated events in G1 R-HSA-69231 2.963298e-02 1.528 0 0
G1 Phase R-HSA-69236 2.963298e-02 1.528 0 0
Nephrin family interactions R-HSA-373753 3.079942e-02 1.511 0 0
Oncogene Induced Senescence R-HSA-2559585 2.807748e-02 1.552 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 3.010732e-02 1.521 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 3.088227e-02 1.510 0 0
rRNA processing R-HSA-72312 2.982522e-02 1.525 0 0
DNA Double-Strand Break Repair R-HSA-5693532 3.103102e-02 1.508 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 3.115902e-02 1.506 0 0
RMTs methylate histone arginines R-HSA-3214858 2.963298e-02 1.528 0 0
Circadian clock R-HSA-9909396 3.059979e-02 1.514 0 0
Death Receptor Signaling R-HSA-73887 3.259440e-02 1.487 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 3.265783e-02 1.486 0 0
Host Interactions of HIV factors R-HSA-162909 3.272641e-02 1.485 0 0
HDACs deacetylate histones R-HSA-3214815 3.279888e-02 1.484 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 3.470396e-02 1.460 0 0
Degradation of DVL R-HSA-4641258 3.470396e-02 1.460 0 0
M Phase R-HSA-68886 3.484890e-02 1.458 0 0
AURKA Activation by TPX2 R-HSA-8854518 3.492757e-02 1.457 0 0
Eukaryotic Translation Termination R-HSA-72764 3.507573e-02 1.455 0 0
Nucleotide Excision Repair R-HSA-5696398 3.514796e-02 1.454 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 3.548811e-02 1.450 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 3.548811e-02 1.450 0 0
Basigin interactions R-HSA-210991 3.548811e-02 1.450 0 0
Signaling by EGFR R-HSA-177929 3.565250e-02 1.448 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 3.571117e-02 1.447 0 0
Signaling downstream of RAS mutants R-HSA-9649948 3.571117e-02 1.447 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 3.571117e-02 1.447 0 0
Signaling by RAS mutants R-HSA-6802949 3.571117e-02 1.447 0 0
Autophagy R-HSA-9612973 3.589562e-02 1.445 0 0
Termination of translesion DNA synthesis R-HSA-5656169 3.599999e-02 1.444 0 0
Formation of annular gap junctions R-HSA-196025 4.136730e-02 1.383 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 3.711725e-02 1.430 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 4.373017e-02 1.359 0 0
DAP12 signaling R-HSA-2424491 4.032157e-02 1.394 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 4.229246e-02 1.374 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 3.904428e-02 1.408 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 4.186059e-02 1.378 0 0
DNA Damage Bypass R-HSA-73893 4.631896e-02 1.334 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 4.032157e-02 1.394 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 4.180204e-02 1.379 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 3.966179e-02 1.402 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 4.032157e-02 1.394 0 0
Cellular response to starvation R-HSA-9711097 3.943675e-02 1.404 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 4.059397e-02 1.392 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 4.059397e-02 1.392 0 0
Membrane Trafficking R-HSA-199991 4.585948e-02 1.339 0 0
Degradation of CDH1 R-HSA-9766229 4.631896e-02 1.334 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 3.837539e-02 1.416 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 4.059397e-02 1.392 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 4.265258e-02 1.370 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 4.373017e-02 1.359 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 4.373017e-02 1.359 0 0
Signaling by FGFR R-HSA-190236 4.210700e-02 1.376 0 0
Signaling by MET R-HSA-6806834 4.447308e-02 1.352 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 4.136730e-02 1.383 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 4.587072e-02 1.338 0 0
Homology Directed Repair R-HSA-5693538 4.351680e-02 1.361 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 4.351680e-02 1.361 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 4.645951e-02 1.333 0 0
Glycogen metabolism R-HSA-8982491 4.645951e-02 1.333 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 4.716966e-02 1.326 0 0
MET interacts with TNS proteins R-HSA-8875513 4.718328e-02 1.326 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 4.718328e-02 1.326 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 4.991316e-02 1.302 0 0
Selenocysteine synthesis R-HSA-2408557 5.007315e-02 1.300 0 0
Regulation of mitotic cell cycle R-HSA-453276 5.007766e-02 1.300 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 5.007766e-02 1.300 0 0
Drug resistance of KIT mutants R-HSA-9669937 6.649522e-02 1.177 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 6.649522e-02 1.177 0 0
KIT mutants bind TKIs R-HSA-9669921 6.649522e-02 1.177 0 0
PDGFR mutants bind TKIs R-HSA-9674428 6.649522e-02 1.177 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 6.649522e-02 1.177 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 6.649522e-02 1.177 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 6.649522e-02 1.177 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 6.649522e-02 1.177 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 6.649522e-02 1.177 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 6.649522e-02 1.177 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 6.649522e-02 1.177 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 6.649522e-02 1.177 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 6.649522e-02 1.177 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 6.649522e-02 1.177 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 6.649522e-02 1.177 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 6.499821e-02 1.187 0 0
Gap junction degradation R-HSA-190873 5.112109e-02 1.291 0 0
ALK mutants bind TKIs R-HSA-9700645 5.112109e-02 1.291 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 5.880385e-02 1.231 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 5.880385e-02 1.231 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 6.725144e-02 1.172 0 0
Deadenylation of mRNA R-HSA-429947 5.845905e-02 1.233 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 5.519056e-02 1.258 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 5.555743e-02 1.255 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 5.880059e-02 1.231 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 5.880059e-02 1.231 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 6.338948e-02 1.198 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 6.496227e-02 1.187 0 0
Viral mRNA Translation R-HSA-192823 5.592561e-02 1.252 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 5.088018e-02 1.293 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 5.356217e-02 1.271 0 0
Signaling by RAF1 mutants R-HSA-9656223 5.555743e-02 1.255 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 5.555743e-02 1.255 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 6.526763e-02 1.185 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 6.526763e-02 1.185 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 5.636777e-02 1.249 0 0
Degradation of CRY and PER proteins R-HSA-9932298 5.555743e-02 1.255 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 5.880385e-02 1.231 0 0
Orc1 removal from chromatin R-HSA-68949 5.880059e-02 1.231 0 0
Clathrin-mediated endocytosis R-HSA-8856828 5.789645e-02 1.237 0 0
Tight junction interactions R-HSA-420029 6.526763e-02 1.185 0 0
Dual Incision in GG-NER R-HSA-5696400 6.671856e-02 1.176 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 5.088018e-02 1.293 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 5.207710e-02 1.283 0 0
Mitophagy R-HSA-5205647 6.671856e-02 1.176 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 6.699202e-02 1.174 0 0
Regulation of PTEN stability and activity R-HSA-8948751 6.338948e-02 1.198 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 6.725144e-02 1.172 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 5.636777e-02 1.249 0 0
Signaling by FGFR4 R-HSA-5654743 6.569005e-02 1.183 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 5.356217e-02 1.271 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 5.618209e-02 1.250 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 5.833600e-02 1.234 0 0
Vpu mediated degradation of CD4 R-HSA-180534 6.079208e-02 1.216 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 6.671856e-02 1.176 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 6.671856e-02 1.176 0 0
Laminin interactions R-HSA-3000157 6.526763e-02 1.185 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 5.880385e-02 1.231 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 6.081111e-02 1.216 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 5.880385e-02 1.231 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 5.096055e-02 1.293 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 5.768696e-02 1.239 0 0
IRE1alpha activates chaperones R-HSA-381070 5.054358e-02 1.296 0 0
Response to metal ions R-HSA-5660526 5.880385e-02 1.231 0 0
Regulation of BACH1 activity R-HSA-9708530 5.096055e-02 1.293 0 0
Glycogen storage diseases R-HSA-3229121 6.725144e-02 1.172 0 0
XBP1(S) activates chaperone genes R-HSA-381038 6.832187e-02 1.165 0 0
SARS-CoV-1-host interactions R-HSA-9692914 6.897987e-02 1.161 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 7.114784e-02 1.148 0 0
Netrin-1 signaling R-HSA-373752 7.114784e-02 1.148 0 0
Signaling by NTRKs R-HSA-166520 7.187687e-02 1.143 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 7.250016e-02 1.140 0 0
MET activates PTK2 signaling R-HSA-8874081 7.250016e-02 1.140 0 0
Myogenesis R-HSA-525793 7.250016e-02 1.140 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 7.250016e-02 1.140 0 0
Synthesis of DNA R-HSA-69239 7.253091e-02 1.139 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 7.296975e-02 1.137 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 7.321885e-02 1.135 0 0
Signaling by NOTCH3 R-HSA-9012852 7.321885e-02 1.135 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 7.459762e-02 1.127 0 0
Ephrin signaling R-HSA-3928664 7.629094e-02 1.118 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 7.629094e-02 1.118 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 7.629094e-02 1.118 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 7.629094e-02 1.118 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 7.629094e-02 1.118 0 0
Nucleosome assembly R-HSA-774815 7.686706e-02 1.114 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 7.686706e-02 1.114 0 0
Signaling by FGFR3 R-HSA-5654741 7.686706e-02 1.114 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 7.686706e-02 1.114 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 7.686706e-02 1.114 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 7.846071e-02 1.105 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 7.846071e-02 1.105 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 7.846071e-02 1.105 0 0
HSF1 activation R-HSA-3371511 7.954429e-02 1.099 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 7.954429e-02 1.099 0 0
GPVI-mediated activation cascade R-HSA-114604 7.954429e-02 1.099 0 0
FLT3 signaling in disease R-HSA-9682385 7.954429e-02 1.099 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 8.015208e-02 1.096 0 0
Interaction between L1 and Ankyrins R-HSA-445095 8.015208e-02 1.096 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 8.015208e-02 1.096 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 8.015208e-02 1.096 0 0
ER-Phagosome pathway R-HSA-1236974 8.066339e-02 1.093 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 8.465737e-02 1.072 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 8.465737e-02 1.072 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 8.465737e-02 1.072 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 8.465737e-02 1.072 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 8.465737e-02 1.072 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 1.058372e-01 0.975 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 8.621510e-02 1.064 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 9.967752e-02 1.001 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 1.139204e-01 0.943 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 1.139204e-01 0.943 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.139204e-01 0.943 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 9.607968e-02 1.017 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 8.821709e-02 1.054 0 0
Formation of the Early Elongation Complex R-HSA-113418 8.821709e-02 1.054 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 9.668720e-02 1.015 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 8.284719e-02 1.082 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 1.090124e-01 0.963 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 1.090124e-01 0.963 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.212042e-01 0.916 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.212042e-01 0.916 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 9.722887e-02 1.012 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.127919e-01 0.948 0 0
Regulation of endogenous retroelements R-HSA-9842860 9.563278e-02 1.019 0 0
HIV Transcription Elongation R-HSA-167169 1.090124e-01 0.963 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 1.090124e-01 0.963 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 8.821709e-02 1.054 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 9.668720e-02 1.015 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 9.975109e-02 1.001 0 0
Deubiquitination R-HSA-5688426 1.014340e-01 0.994 0 0
ESR-mediated signaling R-HSA-8939211 8.614438e-02 1.065 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 1.011788e-01 0.995 0 0
Regulation of RAS by GAPs R-HSA-5658442 1.093424e-01 0.961 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 9.549328e-02 1.020 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.150378e-01 0.939 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 9.967752e-02 1.001 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.079267e-01 0.967 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.175537e-01 0.930 0 0
Peroxisomal protein import R-HSA-9033241 9.549328e-02 1.020 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 1.165955e-01 0.933 0 0
Translation R-HSA-72766 8.815768e-02 1.055 0 0
Ovarian tumor domain proteases R-HSA-5689896 8.643977e-02 1.063 0 0
MET promotes cell motility R-HSA-8875878 9.365274e-02 1.028 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 9.607968e-02 1.017 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 1.171475e-01 0.931 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 9.975109e-02 1.001 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.668720e-02 1.015 0 0
Macroautophagy R-HSA-1632852 8.487417e-02 1.071 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 8.465737e-02 1.072 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.139204e-01 0.943 0 0
Degradation of AXIN R-HSA-4641257 8.643977e-02 1.063 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 8.643977e-02 1.063 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 8.908699e-02 1.050 0 0
Signaling by VEGF R-HSA-194138 1.093191e-01 0.961 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 8.443575e-02 1.073 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.016032e-01 0.993 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 9.418476e-02 1.026 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.006822e-01 0.997 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 8.590660e-02 1.066 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.049602e-01 0.979 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.058372e-01 0.975 0 0
Mitotic Anaphase R-HSA-68882 9.815739e-02 1.008 0 0
EGFR downregulation R-HSA-182971 1.148031e-01 0.940 0 0
Regulation of pyruvate metabolism R-HSA-9861718 8.284719e-02 1.082 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.013243e-01 0.994 0 0
Generic Transcription Pathway R-HSA-212436 9.135535e-02 1.039 0 0
G1/S Transition R-HSA-69206 1.093191e-01 0.961 0 0
MAP kinase activation R-HSA-450294 1.079267e-01 0.967 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 8.284719e-02 1.082 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 1.090124e-01 0.963 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 1.171475e-01 0.931 0 0
Cell Cycle Checkpoints R-HSA-69620 1.105800e-01 0.956 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 1.023374e-01 0.990 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 1.023374e-01 0.990 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.212042e-01 0.916 0 0
Stabilization of p53 R-HSA-69541 1.011788e-01 0.995 0 0
Interleukin-2 family signaling R-HSA-451927 1.090124e-01 0.963 0 0
Negative regulation of MET activity R-HSA-6807004 9.607968e-02 1.017 0 0
G2/M Checkpoints R-HSA-69481 1.184208e-01 0.927 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 1.171475e-01 0.931 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 9.418476e-02 1.026 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 1.180101e-01 0.928 0 0
Signaling by NOTCH4 R-HSA-9013694 1.175537e-01 0.930 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 1.067887e-01 0.971 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 8.904228e-02 1.050 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 9.142230e-02 1.039 0 0
Plasma lipoprotein clearance R-HSA-8964043 1.011788e-01 0.995 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 1.067887e-01 0.971 0 0
Glycogen synthesis R-HSA-3322077 9.607968e-02 1.017 0 0
mRNA 3'-end processing R-HSA-72187 1.240926e-01 0.906 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.243364e-01 0.905 0 0
G0 and Early G1 R-HSA-1538133 1.244256e-01 0.905 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.255011e-01 0.901 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 1.255767e-01 0.901 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.255767e-01 0.901 0 0
Cell surface interactions at the vascular wall R-HSA-202733 1.260131e-01 0.900 0 0
Unfolded Protein Response (UPR) R-HSA-381119 1.262355e-01 0.899 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 1.282489e-01 0.892 0 0
Autointegration results in viral DNA circles R-HSA-177539 1.282489e-01 0.892 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 1.282489e-01 0.892 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 1.282489e-01 0.892 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 1.282489e-01 0.892 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.283727e-01 0.892 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.285725e-01 0.891 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.285725e-01 0.891 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.285725e-01 0.891 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.285725e-01 0.891 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.285725e-01 0.891 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.285725e-01 0.891 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.285725e-01 0.891 0 0
CRMPs in Sema3A signaling R-HSA-399956 1.288785e-01 0.890 0 0
Signal regulatory protein family interactions R-HSA-391160 1.288785e-01 0.890 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.288785e-01 0.890 0 0
Signaling by KIT in disease R-HSA-9669938 1.297180e-01 0.887 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 1.297180e-01 0.887 0 0
mTORC1-mediated signalling R-HSA-166208 1.297180e-01 0.887 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 1.297180e-01 0.887 0 0
Antigen processing-Cross presentation R-HSA-1236975 1.305393e-01 0.884 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.318286e-01 0.880 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 1.344070e-01 0.872 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.344070e-01 0.872 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 1.344070e-01 0.872 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.374241e-01 0.862 0 0
Selective autophagy R-HSA-9663891 1.374241e-01 0.862 0 0
DNA Replication R-HSA-69306 1.379700e-01 0.860 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.426950e-01 0.846 0 0
HATs acetylate histones R-HSA-3214847 1.430001e-01 0.845 0 0
Signaling by SCF-KIT R-HSA-1433557 1.432854e-01 0.844 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 1.432854e-01 0.844 0 0
Response of Mtb to phagocytosis R-HSA-9637690 1.432854e-01 0.844 0 0
Integrin cell surface interactions R-HSA-216083 1.437922e-01 0.842 0 0
Chromosome Maintenance R-HSA-73886 1.453423e-01 0.838 0 0
Influenza Infection R-HSA-168255 1.457203e-01 0.836 0 0
Hedgehog 'off' state R-HSA-5610787 1.491051e-01 0.827 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.501903e-01 0.823 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 1.516355e-01 0.819 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 1.516355e-01 0.819 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 1.516355e-01 0.819 0 0
SOS-mediated signalling R-HSA-112412 1.516355e-01 0.819 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.516355e-01 0.819 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 1.516355e-01 0.819 0 0
PTK6 Expression R-HSA-8849473 1.516355e-01 0.819 0 0
CHL1 interactions R-HSA-447041 1.516355e-01 0.819 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 1.516355e-01 0.819 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 1.516355e-01 0.819 0 0
DAP12 interactions R-HSA-2172127 1.525468e-01 0.817 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 1.553427e-01 0.809 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.553868e-01 0.809 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 1.553868e-01 0.809 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 1.553868e-01 0.809 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 1.553868e-01 0.809 0 0
Calnexin/calreticulin cycle R-HSA-901042 1.553868e-01 0.809 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.553868e-01 0.809 0 0
Signaling by FGFR1 R-HSA-5654736 1.564127e-01 0.806 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.579346e-01 0.802 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 1.606736e-01 0.794 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 1.606736e-01 0.794 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.606736e-01 0.794 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.606736e-01 0.794 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 1.620664e-01 0.790 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 1.620664e-01 0.790 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 1.620664e-01 0.790 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 1.620664e-01 0.790 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.620664e-01 0.790 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.643125e-01 0.784 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.650445e-01 0.782 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.652495e-01 0.782 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.663533e-01 0.779 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.674814e-01 0.776 0 0
Long-term potentiation R-HSA-9620244 1.674814e-01 0.776 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 1.718336e-01 0.765 0 0
Signaling by TGFB family members R-HSA-9006936 1.728825e-01 0.762 0 0
Regulation of TP53 Activity R-HSA-5633007 1.728825e-01 0.762 0 0
Dual incision in TC-NER R-HSA-6782135 1.738830e-01 0.760 0 0
Interleukin-17 signaling R-HSA-448424 1.739236e-01 0.760 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.757683e-01 0.755 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.757683e-01 0.755 0 0
Adrenoceptors R-HSA-390696 1.757683e-01 0.755 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.757683e-01 0.755 0 0
Nef mediated downregulation of CD28 cell surface expression R-HSA-164939 1.865253e-01 0.729 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 1.865253e-01 0.729 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 1.865253e-01 0.729 0 0
Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1) R-HSA-5619096 1.865253e-01 0.729 0 0
Defective VWF binding to collagen type I R-HSA-9845622 1.865253e-01 0.729 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 1.865253e-01 0.729 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 1.865253e-01 0.729 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 1.865253e-01 0.729 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 1.865253e-01 0.729 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 1.865253e-01 0.729 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 2.406272e-01 0.619 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 2.406272e-01 0.619 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 2.406272e-01 0.619 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 2.406272e-01 0.619 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 2.406272e-01 0.619 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) R-HSA-5655799 2.406272e-01 0.619 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 2.406272e-01 0.619 0 0
PLC-gamma1 signalling R-HSA-167021 2.911339e-01 0.536 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 2.911339e-01 0.536 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 2.911339e-01 0.536 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 3.382843e-01 0.471 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 3.382843e-01 0.471 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 3.382843e-01 0.471 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 3.382843e-01 0.471 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 2.254871e-01 0.647 0 0
Folding of actin by CCT/TriC R-HSA-390450 2.254871e-01 0.647 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.945300e-01 0.711 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.945300e-01 0.711 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 1.945300e-01 0.711 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 2.760557e-01 0.559 0 0
Maple Syrup Urine Disease R-HSA-9865114 3.013233e-01 0.521 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 3.013233e-01 0.521 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 3.013233e-01 0.521 0 0
Scavenging by Class F Receptors R-HSA-3000484 3.013233e-01 0.521 0 0
Cristae formation R-HSA-8949613 1.945586e-01 0.711 0 0
Packaging Of Telomere Ends R-HSA-171306 1.945586e-01 0.711 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 2.480545e-01 0.605 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 3.264346e-01 0.486 0 0
Retrograde neurotrophin signalling R-HSA-177504 3.512986e-01 0.454 0 0
Downstream signal transduction R-HSA-186763 2.521579e-01 0.598 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 3.034474e-01 0.518 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.034474e-01 0.518 0 0
Attenuation phase R-HSA-3371568 2.252544e-01 0.647 0 0
Interleukin receptor SHC signaling R-HSA-912526 3.220785e-01 0.492 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 3.220785e-01 0.492 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 3.220785e-01 0.492 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 3.220785e-01 0.492 0 0
HSF1-dependent transactivation R-HSA-3371571 2.239812e-01 0.650 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 2.973973e-01 0.527 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.992082e-01 0.701 0 0
Centrosome maturation R-HSA-380287 2.168448e-01 0.664 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.510358e-01 0.600 0 0
PRC2 methylates histones and DNA R-HSA-212300 3.435043e-01 0.464 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.717824e-01 0.566 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.462699e-01 0.609 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 3.253578e-01 0.488 0 0
Cellular response to heat stress R-HSA-3371556 3.284062e-01 0.484 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.480993e-01 0.605 0 0
Co-inhibition by PD-1 R-HSA-389948 3.418748e-01 0.466 0 0
Chaperonin-mediated protein folding R-HSA-390466 3.425502e-01 0.465 0 0
Protein folding R-HSA-391251 2.728915e-01 0.564 0 0
Ub-specific processing proteases R-HSA-5689880 2.543687e-01 0.595 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 3.223207e-01 0.492 0 0
Telomere Maintenance R-HSA-157579 3.283396e-01 0.484 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 2.521579e-01 0.598 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 2.821834e-01 0.549 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 2.461558e-01 0.609 0 0
G-protein activation R-HSA-202040 2.663850e-01 0.574 0 0
Meiotic synapsis R-HSA-1221632 2.461558e-01 0.609 0 0
Signaling by PDGF R-HSA-186797 3.518065e-01 0.454 0 0
Regulation of CDH11 function R-HSA-9762292 2.254871e-01 0.647 0 0
Generation of second messenger molecules R-HSA-202433 2.252544e-01 0.647 0 0
Regulation of gap junction activity R-HSA-191650 3.382843e-01 0.471 0 0
Activation of RAC1 R-HSA-428540 2.760557e-01 0.559 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 2.129928e-01 0.672 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 2.252544e-01 0.647 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 2.967252e-01 0.528 0 0
Adipogenesis R-HSA-9843745 3.158655e-01 0.500 0 0
Signal attenuation R-HSA-74749 2.254871e-01 0.647 0 0
Integration of provirus R-HSA-162592 2.760557e-01 0.559 0 0
Mitochondrial protein import R-HSA-1268020 2.111435e-01 0.675 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.252544e-01 0.647 0 0
MTOR signalling R-HSA-165159 2.631798e-01 0.580 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 1.945300e-01 0.711 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 2.606979e-01 0.584 0 0
Mitotic Prometaphase R-HSA-68877 2.158942e-01 0.666 0 0
Separation of Sister Chromatids R-HSA-2467813 1.946803e-01 0.711 0 0
Platelet activation, signaling and aggregation R-HSA-76002 2.959285e-01 0.529 0 0
Neurodegenerative Diseases R-HSA-8863678 3.407140e-01 0.468 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 3.407140e-01 0.468 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.906175e-01 0.720 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 1.945300e-01 0.711 0 0
S Phase R-HSA-69242 2.583773e-01 0.588 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 2.004452e-01 0.698 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 2.299298e-01 0.638 0 0
PKMTs methylate histone lysines R-HSA-3214841 2.377188e-01 0.624 0 0
G alpha (z) signalling events R-HSA-418597 2.689273e-01 0.570 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.228676e-01 0.652 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.945586e-01 0.711 0 0
TCR signaling R-HSA-202403 2.244359e-01 0.649 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 1.865253e-01 0.729 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 2.406272e-01 0.619 0 0
Interleukin-33 signaling R-HSA-9014843 2.406272e-01 0.619 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 2.911339e-01 0.536 0 0
Unwinding of DNA R-HSA-176974 2.004452e-01 0.698 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 3.382843e-01 0.471 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 3.382843e-01 0.471 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 2.299298e-01 0.638 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 3.264346e-01 0.486 0 0
Hedgehog 'on' state R-HSA-5632684 1.821873e-01 0.739 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.821834e-01 0.549 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 2.721390e-01 0.565 0 0
Vesicle-mediated transport R-HSA-5653656 3.134807e-01 0.504 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 2.929590e-01 0.533 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 1.945586e-01 0.711 0 0
Aquaporin-mediated transport R-HSA-445717 3.397680e-01 0.469 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 3.220785e-01 0.492 0 0
Cellular response to hypoxia R-HSA-1234174 2.408482e-01 0.618 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.553842e-01 0.593 0 0
NCAM signaling for neurite out-growth R-HSA-375165 3.518065e-01 0.454 0 0
Regulation of TNFR1 signaling R-HSA-5357905 3.156980e-01 0.501 0 0
Post NMDA receptor activation events R-HSA-438064 2.206005e-01 0.656 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 2.377188e-01 0.624 0 0
Signaling by WNT R-HSA-195721 2.779000e-01 0.556 1 0
Hemostasis R-HSA-109582 2.373111e-01 0.625 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.129928e-01 0.672 0 0
TNF signaling R-HSA-75893 2.805038e-01 0.552 0 0
Uptake and function of anthrax toxins R-HSA-5210891 1.945300e-01 0.711 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 3.153562e-01 0.501 0 0
Developmental Biology R-HSA-1266738 1.769458e-01 0.752 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.929590e-01 0.533 0 0
Breakdown of the nuclear lamina R-HSA-352238 1.865253e-01 0.729 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 2.911339e-01 0.536 0 0
TNFR1-mediated ceramide production R-HSA-5626978 3.382843e-01 0.471 0 0
2-LTR circle formation R-HSA-164843 2.254871e-01 0.647 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 2.760557e-01 0.559 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.120683e-01 0.674 0 0
Signaling by FGFR4 in disease R-HSA-5655291 3.512986e-01 0.454 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 3.253578e-01 0.488 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 2.521579e-01 0.598 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.920661e-01 0.717 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 3.377945e-01 0.471 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 3.377945e-01 0.471 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 3.377945e-01 0.471 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 3.241867e-01 0.489 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 2.254871e-01 0.647 0 0
Suppression of apoptosis R-HSA-9635465 2.507367e-01 0.601 0 0
DAG and IP3 signaling R-HSA-1489509 3.024159e-01 0.519 0 0
Muscle contraction R-HSA-397014 3.365223e-01 0.473 0 0
Signaling by FGFR in disease R-HSA-1226099 3.362872e-01 0.473 0 0
NOD1/2 Signaling Pathway R-HSA-168638 3.127070e-01 0.505 0 0
Mitochondrial biogenesis R-HSA-1592230 2.951603e-01 0.530 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.960371e-01 0.708 0 0
MHC class II antigen presentation R-HSA-2132295 3.453180e-01 0.462 0 0
RSV-host interactions R-HSA-9833110 2.806406e-01 0.552 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 3.518065e-01 0.454 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 2.004452e-01 0.698 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 2.254871e-01 0.647 0 0
Bicarbonate transporters R-HSA-425381 2.507367e-01 0.601 0 0
PCP/CE pathway R-HSA-4086400 2.443353e-01 0.612 1 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 2.728955e-01 0.564 0 0
Base Excision Repair R-HSA-73884 2.462699e-01 0.609 0 0
Amyloid fiber formation R-HSA-977225 2.728955e-01 0.564 0 0
Signaling by NOTCH R-HSA-157118 3.385452e-01 0.470 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.776152e-01 0.751 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 3.013233e-01 0.521 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 2.111435e-01 0.675 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 2.406272e-01 0.619 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 2.004452e-01 0.698 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 2.129928e-01 0.672 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 2.670938e-01 0.573 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 2.239812e-01 0.650 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.122826e-01 0.673 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.921485e-01 0.716 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 1.808504e-01 0.743 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 2.521579e-01 0.598 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 2.349873e-01 0.629 0 0
Interleukin-2 signaling R-HSA-9020558 2.507367e-01 0.601 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 3.034474e-01 0.518 0 0
ChREBP activates metabolic gene expression R-HSA-163765 2.507367e-01 0.601 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 2.631798e-01 0.580 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 1.817842e-01 0.740 0 0
Depyrimidination R-HSA-73928 2.631798e-01 0.580 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.848666e-01 0.545 0 0
G1/S-Specific Transcription R-HSA-69205 3.435043e-01 0.464 0 0
Hedgehog ligand biogenesis R-HSA-5358346 2.239812e-01 0.650 0 0
RUNX2 regulates bone development R-HSA-8941326 3.435043e-01 0.464 0 0
Suppression of phagosomal maturation R-HSA-9637687 1.808504e-01 0.743 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 3.284062e-01 0.484 0 0
Signal transduction by L1 R-HSA-445144 2.480545e-01 0.605 0 0
Signaling by NOTCH2 R-HSA-1980145 3.127070e-01 0.505 0 0
Selenoamino acid metabolism R-HSA-2408522 2.763740e-01 0.559 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.893013e-01 0.723 0 0
Pyroptosis R-HSA-5620971 2.085748e-01 0.681 0 0
Translation of Structural Proteins R-HSA-9683701 2.503670e-01 0.601 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 2.120683e-01 0.674 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 3.034474e-01 0.518 0 0
Gap junction trafficking and regulation R-HSA-157858 3.559015e-01 0.449 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 3.559015e-01 0.449 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 3.559015e-01 0.449 0 0
Mitotic Spindle Checkpoint R-HSA-69618 3.568311e-01 0.448 0 0
ABC-family proteins mediated transport R-HSA-382556 3.568311e-01 0.448 0 0
Cleavage of the damaged purine R-HSA-110331 3.589396e-01 0.445 0 0
TGFBR3 expression R-HSA-9839394 3.593110e-01 0.445 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 3.593110e-01 0.445 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 3.599598e-01 0.444 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 3.642510e-01 0.439 1 0
Interleukin-1 signaling R-HSA-9020702 3.664005e-01 0.436 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 3.693298e-01 0.433 0 0
Signaling by FGFR2 in disease R-HSA-5655253 3.693640e-01 0.433 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 3.709478e-01 0.431 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 3.709478e-01 0.431 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 3.709478e-01 0.431 0 0
Potential therapeutics for SARS R-HSA-9679191 3.735396e-01 0.428 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 3.743663e-01 0.427 0 0
Depurination R-HSA-73927 3.743663e-01 0.427 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 3.743663e-01 0.427 0 0
Erythropoietin activates RAS R-HSA-9027284 3.758372e-01 0.425 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 3.758372e-01 0.425 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 3.758372e-01 0.425 0 0
G beta:gamma signalling through BTK R-HSA-8964315 3.758372e-01 0.425 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 3.758372e-01 0.425 0 0
Other semaphorin interactions R-HSA-416700 3.758372e-01 0.425 0 0
Protein methylation R-HSA-8876725 3.758372e-01 0.425 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 3.758372e-01 0.425 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 3.758372e-01 0.425 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 3.778295e-01 0.423 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 3.813928e-01 0.419 0 0
IRS activation R-HSA-74713 3.823011e-01 0.418 0 0
NTRK2 activates RAC1 R-HSA-9032759 3.823011e-01 0.418 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 3.823011e-01 0.418 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 3.823011e-01 0.418 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 3.823011e-01 0.418 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 3.823011e-01 0.418 0 0
Activation of C3 and C5 R-HSA-174577 3.823011e-01 0.418 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 3.823011e-01 0.418 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 3.823011e-01 0.418 0 0
Interleukin-36 pathway R-HSA-9014826 3.823011e-01 0.418 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 3.823011e-01 0.418 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 3.823011e-01 0.418 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 3.823011e-01 0.418 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 3.823011e-01 0.418 0 0
Reelin signalling pathway R-HSA-8866376 3.823011e-01 0.418 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 3.823011e-01 0.418 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 3.871185e-01 0.412 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 3.880690e-01 0.411 0 0
RAS processing R-HSA-9648002 3.897610e-01 0.409 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 3.962328e-01 0.402 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 3.962328e-01 0.402 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 3.962328e-01 0.402 0 0
Neurexins and neuroligins R-HSA-6794361 3.962823e-01 0.402 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 3.962823e-01 0.402 0 0
Phosphorylation of the APC/C R-HSA-176412 3.999838e-01 0.398 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 3.999838e-01 0.398 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 3.999838e-01 0.398 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 3.999838e-01 0.398 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 4.025579e-01 0.395 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 4.051014e-01 0.392 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 4.051014e-01 0.392 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 4.051014e-01 0.392 0 0
Amino acids regulate mTORC1 R-HSA-9639288 4.097071e-01 0.388 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 4.144867e-01 0.382 0 0
Telomere Extension By Telomerase R-HSA-171319 4.144867e-01 0.382 0 0
Insulin receptor recycling R-HSA-77387 4.144867e-01 0.382 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 4.144867e-01 0.382 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 4.203664e-01 0.376 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 4.203664e-01 0.376 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 4.203664e-01 0.376 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 4.203664e-01 0.376 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 4.230374e-01 0.374 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 4.230892e-01 0.374 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 4.233923e-01 0.373 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 4.233923e-01 0.373 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 4.233923e-01 0.373 0 0
Cam-PDE 1 activation R-HSA-111957 4.233923e-01 0.373 0 0
Phosphorylation of Emi1 R-HSA-176417 4.233923e-01 0.373 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 4.233923e-01 0.373 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 4.233923e-01 0.373 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 4.233923e-01 0.373 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 4.233923e-01 0.373 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 4.233923e-01 0.373 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 4.233923e-01 0.373 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 4.233923e-01 0.373 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 4.233923e-01 0.373 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 4.233923e-01 0.373 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 4.233923e-01 0.373 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 4.233923e-01 0.373 0 0
Synthesis of PS R-HSA-1483101 4.233923e-01 0.373 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 4.233923e-01 0.373 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 4.233923e-01 0.373 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 4.233923e-01 0.373 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 4.233923e-01 0.373 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 4.233923e-01 0.373 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 4.236821e-01 0.373 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 4.236821e-01 0.373 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 4.236821e-01 0.373 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 4.236821e-01 0.373 0 0
Fibronectin matrix formation R-HSA-1566977 4.236821e-01 0.373 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 4.236821e-01 0.373 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 4.236821e-01 0.373 0 0
Passive transport by Aquaporins R-HSA-432047 4.236821e-01 0.373 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 4.236821e-01 0.373 0 0
Transcription of the HIV genome R-HSA-167172 4.243060e-01 0.372 0 0
Signaling by Erythropoietin R-HSA-9006335 4.325603e-01 0.364 0 0
DNA methylation R-HSA-5334118 4.325603e-01 0.364 0 0
mRNA Capping R-HSA-72086 4.325603e-01 0.364 0 0
DARPP-32 events R-HSA-180024 4.325603e-01 0.364 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 4.325603e-01 0.364 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 4.326051e-01 0.364 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 4.326051e-01 0.364 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 4.345919e-01 0.362 0 0
Intra-Golgi traffic R-HSA-6811438 4.355362e-01 0.361 0 0
Signaling by FGFR1 in disease R-HSA-5655302 4.355362e-01 0.361 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 4.385399e-01 0.358 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 4.400033e-01 0.357 0 0
Mitotic Prophase R-HSA-68875 4.416918e-01 0.355 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 4.468848e-01 0.350 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 4.468848e-01 0.350 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 4.468848e-01 0.350 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 4.468848e-01 0.350 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 4.468848e-01 0.350 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 4.468848e-01 0.350 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 4.483036e-01 0.348 0 0
Activation of the pre-replicative complex R-HSA-68962 4.504250e-01 0.346 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 4.504250e-01 0.346 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 4.504250e-01 0.346 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 4.552921e-01 0.342 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 4.598174e-01 0.337 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 4.598174e-01 0.337 0 0
ECM proteoglycans R-HSA-3000178 4.602237e-01 0.337 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 4.602237e-01 0.337 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 4.602680e-01 0.337 0 0
Erythropoietin activates STAT5 R-HSA-9027283 4.617524e-01 0.336 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 4.617524e-01 0.336 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 4.617524e-01 0.336 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 4.617524e-01 0.336 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 4.617524e-01 0.336 0 0
G2/M DNA replication checkpoint R-HSA-69478 4.617524e-01 0.336 0 0
CREB phosphorylation R-HSA-199920 4.617524e-01 0.336 0 0
Neurofascin interactions R-HSA-447043 4.617524e-01 0.336 0 0
MyD88-independent TLR4 cascade R-HSA-166166 4.625475e-01 0.335 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 4.625475e-01 0.335 0 0
Defective pyroptosis R-HSA-9710421 4.655166e-01 0.332 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 4.680554e-01 0.330 0 0
Trafficking of AMPA receptors R-HSA-399719 4.680554e-01 0.330 0 0
Molecules associated with elastic fibres R-HSA-2129379 4.680554e-01 0.330 0 0
Amplification of signal from the kinetochores R-HSA-141424 4.686253e-01 0.329 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 4.686253e-01 0.329 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 4.688473e-01 0.329 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 4.695531e-01 0.328 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 4.695531e-01 0.328 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 4.695531e-01 0.328 0 0
Mismatch Repair R-HSA-5358508 4.695531e-01 0.328 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 4.695531e-01 0.328 0 0
Presynaptic function of Kainate receptors R-HSA-500657 4.695531e-01 0.328 0 0
Polo-like kinase mediated events R-HSA-156711 4.695531e-01 0.328 0 0
Synaptic adhesion-like molecules R-HSA-8849932 4.695531e-01 0.328 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 4.695531e-01 0.328 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 4.720787e-01 0.326 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 4.720787e-01 0.326 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 4.759205e-01 0.322 0 0
Organelle biogenesis and maintenance R-HSA-1852241 4.778494e-01 0.321 0 0
Gap junction trafficking R-HSA-190828 4.802933e-01 0.318 0 0
DNA strand elongation R-HSA-69190 4.854282e-01 0.314 0 0
FOXO-mediated transcription R-HSA-9614085 4.856961e-01 0.314 0 0
Pyruvate metabolism R-HSA-70268 4.902982e-01 0.310 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 4.916554e-01 0.308 0 0
STING mediated induction of host immune responses R-HSA-1834941 4.916554e-01 0.308 0 0
Other interleukin signaling R-HSA-449836 4.916554e-01 0.308 0 0
Somitogenesis R-HSA-9824272 4.949071e-01 0.305 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 4.975626e-01 0.303 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 4.975626e-01 0.303 0 0
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 R-HSA-964827 4.975626e-01 0.303 0 0
TRIF-mediated programmed cell death R-HSA-2562578 4.975626e-01 0.303 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 4.975626e-01 0.303 0 0
Disinhibition of SNARE formation R-HSA-114516 4.975626e-01 0.303 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 4.975626e-01 0.303 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 4.975626e-01 0.303 0 0
Reuptake of GABA R-HSA-888593 4.975626e-01 0.303 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 4.975626e-01 0.303 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 4.975626e-01 0.303 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 4.975626e-01 0.303 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 4.975626e-01 0.303 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 4.975626e-01 0.303 0 0
Signaling by Hedgehog R-HSA-5358351 4.999740e-01 0.301 0 0
Diseases of programmed cell death R-HSA-9645723 5.010366e-01 0.300 0 0
RAB geranylgeranylation R-HSA-8873719 5.017459e-01 0.300 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 5.017459e-01 0.300 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 5.017459e-01 0.300 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 5.017459e-01 0.300 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 5.017459e-01 0.300 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 5.017459e-01 0.300 0 0
Nuclear RNA decay R-HSA-9930044 5.025227e-01 0.299 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 5.025227e-01 0.299 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 5.025227e-01 0.299 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 5.025227e-01 0.299 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 5.093441e-01 0.293 0 0
Signaling by TGFBR3 R-HSA-9839373 5.093441e-01 0.293 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 5.131667e-01 0.290 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 5.131667e-01 0.290 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 5.131667e-01 0.290 0 0
Signaling by NODAL R-HSA-1181150 5.131667e-01 0.290 0 0
Co-inhibition by CTLA4 R-HSA-389513 5.131667e-01 0.290 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 5.131667e-01 0.290 0 0
Leishmania phagocytosis R-HSA-9664417 5.168367e-01 0.287 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 5.168367e-01 0.287 0 0
Parasite infection R-HSA-9664407 5.168367e-01 0.287 0 0
Signaling by NOTCH1 R-HSA-1980143 5.186731e-01 0.285 0 0
Interleukin-12 signaling R-HSA-9020591 5.186731e-01 0.285 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 5.193208e-01 0.285 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 5.193208e-01 0.285 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 5.193208e-01 0.285 0 0
Effects of PIP2 hydrolysis R-HSA-114508 5.193208e-01 0.285 0 0
Downstream TCR signaling R-HSA-202424 5.222847e-01 0.282 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 5.235913e-01 0.281 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 5.270623e-01 0.278 0 0
Heme signaling R-HSA-9707616 5.270623e-01 0.278 0 0
Translation of Structural Proteins R-HSA-9694635 5.300752e-01 0.276 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 5.309924e-01 0.275 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 5.309924e-01 0.275 0 0
Type I hemidesmosome assembly R-HSA-446107 5.309924e-01 0.275 0 0
RSK activation R-HSA-444257 5.309924e-01 0.275 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 5.309924e-01 0.275 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 5.309924e-01 0.275 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 5.309924e-01 0.275 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 5.309924e-01 0.275 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 5.309924e-01 0.275 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 5.309924e-01 0.275 0 0
Sodium/Proton exchangers R-HSA-425986 5.309924e-01 0.275 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 5.309924e-01 0.275 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 5.340678e-01 0.272 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 5.340678e-01 0.272 0 0
ERK/MAPK targets R-HSA-198753 5.340678e-01 0.272 0 0
Early Phase of HIV Life Cycle R-HSA-162594 5.340678e-01 0.272 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 5.340678e-01 0.272 0 0
Opioid Signalling R-HSA-111885 5.352656e-01 0.271 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 5.358063e-01 0.271 0 0
eNOS activation R-HSA-203615 5.358063e-01 0.271 0 0
GPER1 signaling R-HSA-9634597 5.376371e-01 0.270 0 0
Co-stimulation by CD28 R-HSA-389356 5.376371e-01 0.270 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 5.376371e-01 0.270 0 0
RNA Polymerase I Transcription R-HSA-73864 5.413643e-01 0.267 0 0
ABC transporter disorders R-HSA-5619084 5.413643e-01 0.267 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 5.517961e-01 0.258 0 0
PERK regulates gene expression R-HSA-381042 5.519651e-01 0.258 0 0
Transferrin endocytosis and recycling R-HSA-917977 5.519651e-01 0.258 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 5.543448e-01 0.256 0 0
Attachment and Entry R-HSA-9694614 5.543448e-01 0.256 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 5.543448e-01 0.256 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 5.545869e-01 0.256 0 0
ARMS-mediated activation R-HSA-170984 5.621997e-01 0.250 0 0
Interleukin-21 signaling R-HSA-9020958 5.621997e-01 0.250 0 0
GP1b-IX-V activation signalling R-HSA-430116 5.621997e-01 0.250 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 5.621997e-01 0.250 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 5.621997e-01 0.250 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 5.621997e-01 0.250 0 0
Cellular response to mitochondrial stress R-HSA-9840373 5.621997e-01 0.250 0 0
Regulation of signaling by NODAL R-HSA-1433617 5.621997e-01 0.250 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 5.621997e-01 0.250 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 5.621997e-01 0.250 0 0
WNT mediated activation of DVL R-HSA-201688 5.621997e-01 0.250 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 5.621997e-01 0.250 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 5.621997e-01 0.250 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 5.635771e-01 0.249 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 5.677855e-01 0.246 0 0
RNA Polymerase III Transcription R-HSA-74158 5.677855e-01 0.246 0 0
Calmodulin induced events R-HSA-111933 5.677855e-01 0.246 0 0
CaM pathway R-HSA-111997 5.677855e-01 0.246 0 0
Triglyceride catabolism R-HSA-163560 5.677855e-01 0.246 0 0
RET signaling R-HSA-8853659 5.677855e-01 0.246 0 0
FGFR2 mutant receptor activation R-HSA-1839126 5.677855e-01 0.246 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 5.739881e-01 0.241 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 5.739881e-01 0.241 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 5.739881e-01 0.241 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 5.832571e-01 0.234 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 5.832571e-01 0.234 0 0
Metabolism of folate and pterines R-HSA-196757 5.832571e-01 0.234 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 5.837875e-01 0.234 0 0
Neutrophil degranulation R-HSA-6798695 5.869287e-01 0.231 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 5.902550e-01 0.229 0 0
Formation of apoptosome R-HSA-111458 5.913323e-01 0.228 0 0
PI3K/AKT activation R-HSA-198203 5.913323e-01 0.228 0 0
Regulation of the apoptosome activity R-HSA-9627069 5.913323e-01 0.228 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 5.913323e-01 0.228 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 5.913323e-01 0.228 1 1
DNA replication initiation R-HSA-68952 5.913323e-01 0.228 0 0
Formation of intermediate mesoderm R-HSA-9761174 5.913323e-01 0.228 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 5.913323e-01 0.228 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 5.913323e-01 0.228 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 5.913323e-01 0.228 0 0
Signaling by Leptin R-HSA-2586552 5.913323e-01 0.228 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 5.916066e-01 0.228 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 5.921665e-01 0.228 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 5.929923e-01 0.227 0 0
Formation of the ureteric bud R-HSA-9830674 5.929923e-01 0.227 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 5.929923e-01 0.227 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 5.958967e-01 0.225 0 0
Elastic fibre formation R-HSA-1566948 5.983717e-01 0.223 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 6.034097e-01 0.219 0 0
Viral Infection Pathways R-HSA-9824446 6.084917e-01 0.216 0 0
Signaling by Interleukins R-HSA-449147 6.090475e-01 0.215 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 6.113554e-01 0.214 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 6.113554e-01 0.214 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 6.113554e-01 0.214 0 0
Thromboxane signalling through TP receptor R-HSA-428930 6.113554e-01 0.214 0 0
Complex III assembly R-HSA-9865881 6.113554e-01 0.214 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 6.113554e-01 0.214 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 6.113554e-01 0.214 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 6.113554e-01 0.214 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 6.131225e-01 0.212 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 6.131225e-01 0.212 0 0
Signaling by ALK R-HSA-201556 6.131225e-01 0.212 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 6.131225e-01 0.212 0 0
Meiosis R-HSA-1500620 6.167187e-01 0.210 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 6.185280e-01 0.209 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 6.185280e-01 0.209 0 0
vRNP Assembly R-HSA-192905 6.185280e-01 0.209 0 0
Synthesis of PI R-HSA-1483226 6.185280e-01 0.209 0 0
Transport of RCbl within the body R-HSA-9758890 6.185280e-01 0.209 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 6.185280e-01 0.209 0 0
Interleukin-1 family signaling R-HSA-446652 6.212373e-01 0.207 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 6.219137e-01 0.206 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 6.275043e-01 0.202 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 6.275043e-01 0.202 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 6.275043e-01 0.202 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 6.290786e-01 0.201 0 0
G protein gated Potassium channels R-HSA-1296059 6.290786e-01 0.201 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 6.290786e-01 0.201 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 6.290786e-01 0.201 0 0
HDMs demethylate histones R-HSA-3214842 6.290786e-01 0.201 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 6.290786e-01 0.201 0 0
Interleukin-7 signaling R-HSA-1266695 6.290786e-01 0.201 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 6.303783e-01 0.200 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 6.439154e-01 0.191 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 6.439154e-01 0.191 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 6.439154e-01 0.191 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 6.439154e-01 0.191 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 6.439154e-01 0.191 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 6.439154e-01 0.191 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 6.439154e-01 0.191 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 6.439154e-01 0.191 0 0
Anchoring fibril formation R-HSA-2214320 6.439154e-01 0.191 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 6.439154e-01 0.191 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 6.461658e-01 0.190 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 6.461658e-01 0.190 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 6.461658e-01 0.190 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 6.461658e-01 0.190 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 6.461658e-01 0.190 0 0
Interleukin-12 family signaling R-HSA-447115 6.467848e-01 0.189 0 0
Nuclear Envelope Breakdown R-HSA-2980766 6.535431e-01 0.185 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 6.551471e-01 0.184 0 0
HIV Transcription Initiation R-HSA-167161 6.551471e-01 0.184 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 6.551471e-01 0.184 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 6.592114e-01 0.181 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 6.626231e-01 0.179 0 0
Signaling by FGFR3 in disease R-HSA-5655332 6.626231e-01 0.179 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 6.626231e-01 0.179 0 0
Developmental Cell Lineages R-HSA-9734767 6.631487e-01 0.178 0 0
G2/M DNA damage checkpoint R-HSA-69473 6.648302e-01 0.177 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 6.653943e-01 0.177 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 6.676146e-01 0.175 0 0
GRB2 events in EGFR signaling R-HSA-179812 6.676146e-01 0.175 0 0
Leading Strand Synthesis R-HSA-69109 6.676146e-01 0.175 0 0
Polymerase switching R-HSA-69091 6.676146e-01 0.175 0 0
Repression of WNT target genes R-HSA-4641265 6.676146e-01 0.175 0 0
MET activates RAS signaling R-HSA-8851805 6.676146e-01 0.175 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 6.676146e-01 0.175 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 6.676146e-01 0.175 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 6.676146e-01 0.175 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 6.676146e-01 0.175 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 6.676146e-01 0.175 0 0
Pervasive developmental disorders R-HSA-9005895 6.676146e-01 0.175 0 0
Disorders of Nervous System Development R-HSA-9697154 6.676146e-01 0.175 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 6.676146e-01 0.175 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 6.676146e-01 0.175 0 0
Signaling by LTK R-HSA-9842663 6.676146e-01 0.175 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 6.676146e-01 0.175 0 0
Interleukin-15 signaling R-HSA-8983432 6.676146e-01 0.175 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 6.684042e-01 0.175 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 6.684042e-01 0.175 0 0
Ca-dependent events R-HSA-111996 6.684042e-01 0.175 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 6.750478e-01 0.171 0 0
Neurotransmitter release cycle R-HSA-112310 6.753777e-01 0.170 0 0
Extension of Telomeres R-HSA-180786 6.764788e-01 0.170 0 0
Adaptive Immune System R-HSA-1280218 6.770356e-01 0.169 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 6.784586e-01 0.168 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 6.784586e-01 0.168 0 0
Cilium Assembly R-HSA-5617833 6.793987e-01 0.168 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 6.812846e-01 0.167 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 6.845707e-01 0.165 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 6.850565e-01 0.164 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 6.897379e-01 0.161 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 6.897379e-01 0.161 0 0
Formation of axial mesoderm R-HSA-9796292 6.897379e-01 0.161 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 6.897379e-01 0.161 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 6.897379e-01 0.161 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 6.897379e-01 0.161 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 6.897379e-01 0.161 0 0
rRNA modification in the mitochondrion R-HSA-6793080 6.897379e-01 0.161 0 0
Maturation of nucleoprotein R-HSA-9683610 6.897379e-01 0.161 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 6.897379e-01 0.161 0 0
Thyroxine biosynthesis R-HSA-209968 6.936821e-01 0.159 0 0
Platelet calcium homeostasis R-HSA-418360 6.936821e-01 0.159 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 6.936821e-01 0.159 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 6.936821e-01 0.159 0 0
Glucagon-type ligand receptors R-HSA-420092 6.936821e-01 0.159 0 0
ER to Golgi Anterograde Transport R-HSA-199977 6.977850e-01 0.156 0 0
Viral Messenger RNA Synthesis R-HSA-168325 6.983372e-01 0.156 0 0
Formation of paraxial mesoderm R-HSA-9793380 6.983372e-01 0.156 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 7.024401e-01 0.153 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 7.024401e-01 0.153 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 7.059195e-01 0.151 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 7.059195e-01 0.151 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 7.083050e-01 0.150 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 7.083050e-01 0.150 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 7.083050e-01 0.150 0 0
Activation of BH3-only proteins R-HSA-114452 7.083050e-01 0.150 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 7.083050e-01 0.150 0 0
Interleukin-37 signaling R-HSA-9008059 7.083050e-01 0.150 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 7.098971e-01 0.149 0 0
Gene Silencing by RNA R-HSA-211000 7.099932e-01 0.149 0 0
Removal of the Flap Intermediate R-HSA-69166 7.103899e-01 0.149 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 7.103899e-01 0.149 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 7.103899e-01 0.149 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 7.103899e-01 0.149 0 0
N-glycan trimming and elongation in the cis-Golgi R-HSA-964739 7.103899e-01 0.149 0 0
Zinc transporters R-HSA-435354 7.103899e-01 0.149 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 7.191143e-01 0.143 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 7.191143e-01 0.143 0 0
PKR-mediated signaling R-HSA-9833482 7.229805e-01 0.141 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 7.296684e-01 0.137 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 7.296684e-01 0.137 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 7.296684e-01 0.137 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 7.296684e-01 0.137 0 0
Processive synthesis on the lagging strand R-HSA-69183 7.296684e-01 0.137 0 0
Telomere C-strand synthesis initiation R-HSA-174430 7.296684e-01 0.137 0 0
SHC1 events in EGFR signaling R-HSA-180336 7.296684e-01 0.137 0 0
Signaling by Activin R-HSA-1502540 7.296684e-01 0.137 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 7.296684e-01 0.137 0 0
DNA Damage Reversal R-HSA-73942 7.296684e-01 0.137 0 0
Transmission across Chemical Synapses R-HSA-112315 7.342190e-01 0.134 0 0
Inwardly rectifying K+ channels R-HSA-1296065 7.357999e-01 0.133 0 0
HS-GAG degradation R-HSA-2024096 7.357999e-01 0.133 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 7.357999e-01 0.133 0 0
Metal ion SLC transporters R-HSA-425410 7.400955e-01 0.131 0 0
SARS-CoV Infections R-HSA-9679506 7.436521e-01 0.129 0 0
COPI-mediated anterograde transport R-HSA-6807878 7.440632e-01 0.128 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 7.476647e-01 0.126 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 7.476647e-01 0.126 0 0
Prolonged ERK activation events R-HSA-169893 7.476647e-01 0.126 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 7.476647e-01 0.126 0 0
Fructose catabolism R-HSA-70350 7.476647e-01 0.126 0 0
Carnitine synthesis R-HSA-71262 7.476647e-01 0.126 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 7.476647e-01 0.126 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 7.476647e-01 0.126 0 0
Differentiation of T cells R-HSA-9945266 7.476647e-01 0.126 0 0
FCERI mediated MAPK activation R-HSA-2871796 7.482577e-01 0.126 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 7.486996e-01 0.126 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 7.486996e-01 0.126 0 0
G-protein beta:gamma signalling R-HSA-397795 7.486996e-01 0.126 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 7.486996e-01 0.126 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 7.486996e-01 0.126 0 0
FGFR1 mutant receptor activation R-HSA-1839124 7.486996e-01 0.126 0 0
Activation of ATR in response to replication stress R-HSA-176187 7.486996e-01 0.126 0 0
Resolution of D-Loop Structures R-HSA-5693537 7.610539e-01 0.119 0 0
Heme degradation R-HSA-189483 7.610539e-01 0.119 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 7.644639e-01 0.117 0 0
Disorders of Developmental Biology R-HSA-9675151 7.644639e-01 0.117 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 7.663766e-01 0.116 0 0
Ion channel transport R-HSA-983712 7.670806e-01 0.115 0 0
Cellular response to chemical stress R-HSA-9711123 7.691624e-01 0.114 0 0
Extracellular matrix organization R-HSA-1474244 7.694611e-01 0.114 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 7.701549e-01 0.113 0 0
Meiotic recombination R-HSA-912446 7.710397e-01 0.113 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 7.728781e-01 0.112 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 7.728781e-01 0.112 0 0
Nuclear import of Rev protein R-HSA-180746 7.728781e-01 0.112 0 0
RAF activation R-HSA-5673000 7.728781e-01 0.112 0 0
Signal amplification R-HSA-392518 7.728781e-01 0.112 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 7.728781e-01 0.112 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 7.801457e-01 0.108 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 7.801457e-01 0.108 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 7.801457e-01 0.108 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 7.801457e-01 0.108 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 7.801457e-01 0.108 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 7.806616e-01 0.108 0 0
COPII-mediated vesicle transport R-HSA-204005 7.834535e-01 0.106 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 7.841881e-01 0.106 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 7.841881e-01 0.106 0 0
Signalling to ERKs R-HSA-187687 7.841881e-01 0.106 0 0
PI Metabolism R-HSA-1483255 7.882643e-01 0.103 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 7.916122e-01 0.101 0 0
Metabolism of porphyrins R-HSA-189445 7.916122e-01 0.101 0 0
Interferon Signaling R-HSA-913531 7.928541e-01 0.101 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 7.947843e-01 0.100 0 0
PKA activation R-HSA-163615 7.947843e-01 0.100 0 0
PKA activation in glucagon signalling R-HSA-164378 7.947843e-01 0.100 0 0
Apoptotic factor-mediated response R-HSA-111471 7.947843e-01 0.100 0 0
Platelet sensitization by LDL R-HSA-432142 7.947843e-01 0.100 0 0
Transport of connexons to the plasma membrane R-HSA-190872 7.947843e-01 0.100 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 7.947843e-01 0.100 0 0
Tie2 Signaling R-HSA-210993 7.947843e-01 0.100 0 0
GAB1 signalosome R-HSA-180292 7.947843e-01 0.100 0 0
HS-GAG biosynthesis R-HSA-2022928 7.950000e-01 0.100 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 7.989042e-01 0.098 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 7.995224e-01 0.097 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 8.029066e-01 0.095 0 0
Collagen chain trimerization R-HSA-8948216 8.053298e-01 0.094 0 0
Ca2+ pathway R-HSA-4086398 8.071882e-01 0.093 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 8.071882e-01 0.093 0 0
Crosslinking of collagen fibrils R-HSA-2243919 8.084490e-01 0.092 0 0
Germ layer formation at gastrulation R-HSA-9754189 8.084490e-01 0.092 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 8.084490e-01 0.092 0 0
The NLRP3 inflammasome R-HSA-844456 8.084490e-01 0.092 0 0
Diseases of hemostasis R-HSA-9671793 8.084490e-01 0.092 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 8.084490e-01 0.092 0 0
Rap1 signalling R-HSA-392517 8.084490e-01 0.092 0 0
Specification of the neural plate border R-HSA-9834899 8.084490e-01 0.092 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 8.084490e-01 0.092 0 0
Maturation of nucleoprotein R-HSA-9694631 8.084490e-01 0.092 0 0
Neuronal System R-HSA-112316 8.150177e-01 0.089 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 8.151938e-01 0.089 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 8.151938e-01 0.089 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 8.158586e-01 0.088 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 8.212046e-01 0.086 0 0
Formation of definitive endoderm R-HSA-9823730 8.212046e-01 0.086 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 8.212046e-01 0.086 0 0
Protein hydroxylation R-HSA-9629569 8.212046e-01 0.086 0 0
Dectin-2 family R-HSA-5621480 8.238710e-01 0.084 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 8.246082e-01 0.084 0 0
Signaling by Insulin receptor R-HSA-74752 8.295403e-01 0.081 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 8.315837e-01 0.080 0 0
Stimuli-sensing channels R-HSA-2672351 8.321857e-01 0.080 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 8.331115e-01 0.079 0 0
Lagging Strand Synthesis R-HSA-69186 8.331115e-01 0.079 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 8.331115e-01 0.079 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 8.331115e-01 0.079 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 8.331115e-01 0.079 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 8.331115e-01 0.079 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 8.331115e-01 0.079 0 0
Signalling to RAS R-HSA-167044 8.331115e-01 0.079 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 8.356786e-01 0.078 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 8.390044e-01 0.076 0 0
Amino acid transport across the plasma membrane R-HSA-352230 8.390044e-01 0.076 0 0
Triglyceride metabolism R-HSA-8979227 8.390044e-01 0.076 0 0
PPARA activates gene expression R-HSA-1989781 8.399793e-01 0.076 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.405367e-01 0.075 0 0
Mitochondrial protein degradation R-HSA-9837999 8.416349e-01 0.075 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 8.442261e-01 0.074 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 8.442261e-01 0.074 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 8.442261e-01 0.074 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 8.442261e-01 0.074 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 8.442261e-01 0.074 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 8.442261e-01 0.074 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 8.442261e-01 0.074 0 0
tRNA Aminoacylation R-HSA-379724 8.461408e-01 0.073 0 0
Signaling by Retinoic Acid R-HSA-5362517 8.461408e-01 0.073 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 8.482877e-01 0.071 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.490801e-01 0.071 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.503144e-01 0.070 0 0
Scavenging by Class A Receptors R-HSA-3000480 8.503144e-01 0.070 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 8.503144e-01 0.070 0 0
Heme biosynthesis R-HSA-189451 8.503144e-01 0.070 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.503144e-01 0.070 0 0
Collagen degradation R-HSA-1442490 8.530009e-01 0.069 0 0
PLC beta mediated events R-HSA-112043 8.530009e-01 0.069 0 0
Inositol phosphate metabolism R-HSA-1483249 8.538121e-01 0.069 0 0
Toll-like Receptor Cascades R-HSA-168898 8.539225e-01 0.069 0 0
Notch-HLH transcription pathway R-HSA-350054 8.546011e-01 0.068 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 8.546011e-01 0.068 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 8.546011e-01 0.068 0 0
LDL clearance R-HSA-8964038 8.546011e-01 0.068 0 0
Fructose metabolism R-HSA-5652084 8.546011e-01 0.068 0 0
Ethanol oxidation R-HSA-71384 8.546011e-01 0.068 0 0
Cytokine Signaling in Immune system R-HSA-1280215 8.549497e-01 0.068 0 0
Platelet degranulation R-HSA-114608 8.558681e-01 0.068 0 0
Activation of GABAB receptors R-HSA-991365 8.580898e-01 0.066 0 0
GABA B receptor activation R-HSA-977444 8.580898e-01 0.066 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 8.580898e-01 0.066 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 8.588468e-01 0.066 0 0
tRNA processing in the nucleus R-HSA-6784531 8.595925e-01 0.066 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 8.642857e-01 0.063 0 0
Termination of O-glycan biosynthesis R-HSA-977068 8.642857e-01 0.063 0 0
Interleukin-20 family signaling R-HSA-8854691 8.642857e-01 0.063 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 8.642857e-01 0.063 0 0
Organic anion transport by SLCO transporters R-HSA-879518 8.642857e-01 0.063 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 8.642857e-01 0.063 0 0
Growth hormone receptor signaling R-HSA-982772 8.642857e-01 0.063 0 0
TBC/RABGAPs R-HSA-8854214 8.654942e-01 0.063 0 0
Post-translational protein phosphorylation R-HSA-8957275 8.688012e-01 0.061 0 0
SARS-CoV-2-host interactions R-HSA-9705683 8.701122e-01 0.060 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.713664e-01 0.060 0 0
Ion transport by P-type ATPases R-HSA-936837 8.720015e-01 0.059 0 0
Amine ligand-binding receptors R-HSA-375280 8.725425e-01 0.059 0 0
Proteasome assembly R-HSA-9907900 8.725425e-01 0.059 0 0
Surfactant metabolism R-HSA-5683826 8.725425e-01 0.059 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 8.733258e-01 0.059 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 8.733258e-01 0.059 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 8.733258e-01 0.059 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 8.733258e-01 0.059 0 0
Interferon alpha/beta signaling R-HSA-909733 8.775741e-01 0.057 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 8.792493e-01 0.056 0 0
Leishmania infection R-HSA-9658195 8.793277e-01 0.056 0 0
Parasitic Infection Pathways R-HSA-9824443 8.793277e-01 0.056 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 8.817642e-01 0.055 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 8.817642e-01 0.055 0 0
Hyaluronan degradation R-HSA-2160916 8.817642e-01 0.055 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 8.817642e-01 0.055 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 8.817642e-01 0.055 0 0
SARS-CoV-2 Infection R-HSA-9694516 8.846519e-01 0.053 0 0
HCMV Infection R-HSA-9609646 8.865607e-01 0.052 0 0
Gastrulation R-HSA-9758941 8.870244e-01 0.052 0 0
SLC-mediated transport of amino acids R-HSA-9958863 8.887964e-01 0.051 0 0
G-protein mediated events R-HSA-112040 8.887964e-01 0.051 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 8.896410e-01 0.051 0 0
TRP channels R-HSA-3295583 8.896410e-01 0.051 0 0
Sphingolipid catabolism R-HSA-9845614 8.896410e-01 0.051 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 8.896410e-01 0.051 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 8.896410e-01 0.051 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 8.928520e-01 0.049 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 8.939404e-01 0.049 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 8.969934e-01 0.047 0 0
Signaling by BMP R-HSA-201451 8.969934e-01 0.047 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 8.969934e-01 0.047 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 8.969934e-01 0.047 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 8.969934e-01 0.047 0 0
Insulin processing R-HSA-264876 8.969934e-01 0.047 0 0
Maturation of hRSV A proteins R-HSA-9828806 8.969934e-01 0.047 0 0
Intraflagellar transport R-HSA-5620924 8.974604e-01 0.047 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 8.988697e-01 0.046 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 9.001401e-01 0.046 0 0
Activation of HOX genes during differentiation R-HSA-5619507 9.001401e-01 0.046 0 0
Neddylation R-HSA-8951664 9.010812e-01 0.045 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.017225e-01 0.045 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.038565e-01 0.044 0 0
Inflammasomes R-HSA-622312 9.038565e-01 0.044 0 0
Platelet homeostasis R-HSA-418346 9.078082e-01 0.042 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 9.124727e-01 0.040 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.130859e-01 0.039 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.130859e-01 0.039 0 0
HCMV Late Events R-HSA-9610379 9.134596e-01 0.039 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 9.143755e-01 0.039 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 9.162423e-01 0.038 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.162423e-01 0.038 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 9.162423e-01 0.038 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.205478e-01 0.036 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 9.218238e-01 0.035 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 9.218238e-01 0.035 0 0
HCMV Early Events R-HSA-9609690 9.245353e-01 0.034 0 0
Collagen formation R-HSA-1474290 9.266496e-01 0.033 0 0
DAG1 glycosylations R-HSA-8931838 9.270337e-01 0.033 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.282139e-01 0.032 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 9.318967e-01 0.031 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 9.318967e-01 0.031 0 0
Cardiogenesis R-HSA-9733709 9.318967e-01 0.031 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.342637e-01 0.030 0 0
Ion homeostasis R-HSA-5578775 9.342637e-01 0.030 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.342637e-01 0.030 0 0
Interleukin-10 signaling R-HSA-6783783 9.347361e-01 0.029 0 0
Reproduction R-HSA-1474165 9.354744e-01 0.029 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.358874e-01 0.029 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.362745e-01 0.029 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 9.364359e-01 0.029 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.364359e-01 0.029 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.364359e-01 0.029 0 0
IRS-mediated signalling R-HSA-112399 9.378668e-01 0.028 0 0
Synthesis of PA R-HSA-1483166 9.378668e-01 0.028 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.388937e-01 0.027 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.406728e-01 0.027 0 0
Gap junction assembly R-HSA-190861 9.406728e-01 0.027 0 0
Hyaluronan metabolism R-HSA-2142845 9.406728e-01 0.027 0 0
RA biosynthesis pathway R-HSA-5365859 9.406728e-01 0.027 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.406728e-01 0.027 0 0
Regulation of insulin secretion R-HSA-422356 9.414457e-01 0.026 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.445181e-01 0.025 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 9.446275e-01 0.025 0 0
Rab regulation of trafficking R-HSA-9007101 9.461804e-01 0.024 0 0
GABA receptor activation R-HSA-977443 9.475841e-01 0.023 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.475841e-01 0.023 0 0
Metabolism of polyamines R-HSA-351202 9.475841e-01 0.023 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.483188e-01 0.023 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 9.504881e-01 0.022 0 0
Integration of energy metabolism R-HSA-163685 9.511764e-01 0.022 0 0
Voltage gated Potassium channels R-HSA-1296072 9.517642e-01 0.021 0 0
NCAM1 interactions R-HSA-419037 9.517642e-01 0.021 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.517642e-01 0.021 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.517642e-01 0.021 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.549802e-01 0.020 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 9.563552e-01 0.019 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 9.579819e-01 0.019 0 0
Insulin receptor signalling cascade R-HSA-74751 9.583063e-01 0.018 0 0
IGF1R signaling cascade R-HSA-2428924 9.583063e-01 0.018 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 9.606387e-01 0.017 0 0
Diseases of Immune System R-HSA-5260271 9.607836e-01 0.017 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.607836e-01 0.017 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.607836e-01 0.017 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.607836e-01 0.017 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.628457e-01 0.016 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 9.633987e-01 0.016 0 0
Maturation of spike protein R-HSA-9694548 9.633987e-01 0.016 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.633987e-01 0.016 0 0
Kidney development R-HSA-9830369 9.649335e-01 0.016 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.658395e-01 0.015 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.662445e-01 0.015 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.705416e-01 0.013 0 0
Retinoid metabolism and transport R-HSA-975634 9.722109e-01 0.012 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.722288e-01 0.012 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.722288e-01 0.012 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 9.740812e-01 0.011 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.756379e-01 0.011 0 0
G alpha (s) signalling events R-HSA-418555 9.758086e-01 0.011 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 9.758102e-01 0.011 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.758102e-01 0.011 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.758102e-01 0.011 0 0
Diseases of DNA repair R-HSA-9675135 9.758102e-01 0.011 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.758102e-01 0.011 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.772195e-01 0.010 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.774239e-01 0.010 0 0
Synthesis of PC R-HSA-1483191 9.774239e-01 0.010 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.774239e-01 0.010 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.777130e-01 0.010 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.777130e-01 0.010 0 0
Potassium Channels R-HSA-1296071 9.777965e-01 0.010 0 0
Gluconeogenesis R-HSA-70263 9.789301e-01 0.009 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.803359e-01 0.009 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.815859e-01 0.008 0 0
PI3K Cascade R-HSA-109704 9.816479e-01 0.008 0 0
The phototransduction cascade R-HSA-2514856 9.828725e-01 0.008 0 0
Phospholipid metabolism R-HSA-1483257 9.830707e-01 0.007 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.845879e-01 0.007 0 0
Nucleotide biosynthesis R-HSA-8956320 9.850822e-01 0.007 0 0
G alpha (q) signalling events R-HSA-416476 9.868005e-01 0.006 0 0
Infectious disease R-HSA-5663205 9.869859e-01 0.006 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.870070e-01 0.006 0 0
Paracetamol ADME R-HSA-9753281 9.870070e-01 0.006 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.874280e-01 0.005 0 0
Innate Immune System R-HSA-168249 9.885704e-01 0.005 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.887914e-01 0.005 0 0
Immune System R-HSA-168256 9.896798e-01 0.005 0 0
Metabolism of non-coding RNA R-HSA-194441 9.901441e-01 0.004 0 0
snRNP Assembly R-HSA-191859 9.901441e-01 0.004 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.911848e-01 0.004 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.932686e-01 0.003 0 0
FCGR activation R-HSA-2029481 9.933557e-01 0.003 0 0
Interferon gamma signaling R-HSA-877300 9.935046e-01 0.003 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.938547e-01 0.003 0 0
Nicotinate metabolism R-HSA-196807 9.943301e-01 0.002 0 0
O-linked glycosylation of mucins R-HSA-913709 9.947088e-01 0.002 0 0
Mitochondrial translation elongation R-HSA-5389840 9.947907e-01 0.002 0 0
Mitochondrial translation initiation R-HSA-5368286 9.953895e-01 0.002 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.953921e-01 0.002 0 0
SLC transporter disorders R-HSA-5619102 9.956202e-01 0.002 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.957000e-01 0.002 0 0
Metabolism of cofactors R-HSA-8978934 9.957000e-01 0.002 0 0
Glycolysis R-HSA-70171 9.959205e-01 0.002 0 0
Aspirin ADME R-HSA-9749641 9.962554e-01 0.002 0 0
tRNA processing R-HSA-72306 9.964122e-01 0.002 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.966064e-01 0.001 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.968308e-01 0.001 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.968941e-01 0.001 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.972077e-01 0.001 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.975273e-01 0.001 0 0
Mitochondrial translation termination R-HSA-5419276 9.977962e-01 0.001 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.982505e-01 0.001 0 0
Disease R-HSA-1643685 9.985124e-01 0.001 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.985785e-01 0.001 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.986573e-01 0.001 0 0
Glucose metabolism R-HSA-70326 9.988165e-01 0.001 0 0
Visual phototransduction R-HSA-2187338 9.991347e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.992365e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.992585e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.993575e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.993587e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.994569e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.994969e-01 0.000 0 0
Cardiac conduction R-HSA-5576891 9.995669e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.995885e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.997128e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.997220e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.997391e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.997810e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.997957e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.998235e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.998332e-01 0.000 0 0
Initial triggering of complement R-HSA-166663 9.998452e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.998492e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.998827e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.998953e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999095e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999226e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999258e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999277e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999327e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999476e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999728e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999761e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999763e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999873e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999922e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999927e-01 0.000 0 0
Diseases of metabolism R-HSA-5668914 9.999968e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999973e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999988e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999993e-01 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 9.999997e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999999e-01 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways