PKMYT1

TYR version of PSPA with Y as phospho-acceptor
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
Y Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: Y Sites / Y Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
O43390 Y136 Sugiyama HNRNPR HNRPR QESTKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVY
O60506 Y133 Sugiyama SYNCRIP HNRPQ NSAP1 ADSSKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVY
O60841 S182 Sugiyama EIF5B IF2 KIAA0741 DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O95218 S181 Sugiyama ZRANB2 ZIS ZNF265 DEDLsKyKLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRR
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P06493 T14 GPS6|SIGNOR|EPSD|PSP CDK1 CDC2 CDC28A CDKN1 P34CDC2 _______MEDyTKIEKIGEGtyGVVyKGRHKTTGQVVAMKK
P06493 Y15 SIGNOR|EPSD|PSP CDK1 CDC2 CDC28A CDKN1 P34CDC2 ______MEDyTKIEKIGEGtyGVVyKGRHKTTGQVVAMKKI
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11142 Y41 Sugiyama HSPA8 HSC70 HSP73 HSPA10 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17066 Y43 Sugiyama HSPA6 HSP70B' FQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAAL
P19338 Y462 Sugiyama NCL AEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNSTWs
P22059 S193 Sugiyama OSBP OSBP1 VTALELAKAKAVKMLAEsDEsGDEEsVsQtDKTELQNTLRT
P27348 Y48 Sugiyama YWHAQ AVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSIEQK
P29692 S162 Sugiyama EEF1D EF1D AKKPAtPAEDDEDDDIDLFGsDNEEEDKEAAQLREERLRQY
P30101 Y100 Sugiyama PDIA3 ERP57 ERP60 GRP58 LAKVDCTANTNTCNKyGVsGyPtLKIFRDGEEAGAyDGPRt
P31946 Y50 Sugiyama YWHAB AVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSIEQK
P31947 Y48 Sugiyama SFN HME1 GAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsIEQK
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P34931 Y43 Sugiyama HSPA1L FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P46783 S146 Sugiyama RPS10 TYRRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ_
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P48741 Y43 Sugiyama HSPA7 HSP70B FQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAAL
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P54652 Y42 Sugiyama HSPA2 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P61247 Y256 Sugiyama RPS3A FTE1 MFTL sssGKAtGDEtGAKVERADGyEPPVQEsV____________
P61353 Y85 Sugiyama RPL27 RSKIKSFVKVyNyNHLMPtRysVDIPLDKtVVNKDVFRDPA
P61981 Y49 Sugiyama YWHAG NVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSIEQK
P62249 Y115 Sugiyama RPS16 YYQKYVDEASKKEIKDILIQyDRtLLVADPRRCESKKFGGP
P62258 Y49 Sugiyama YWHAE KVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssIEQK
P62269 Y95 Sugiyama RPS18 D6S218E RQYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLK
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62906 S64 Sugiyama RPL10A NEDD6 QKDKRFsGTVRLKSTPRPKFsVCVLGDQQHCDEAKAVDIPH
P63104 Y48 Sugiyama YWHAZ sVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssIEQK
P67809 S102 Sugiyama YBX1 NSEP1 YB1 EDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEA
Q00839 Y257 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 QKGGDKKRGVKRPREDHGRGyFEyIEENKysRAKsPQPPVE
Q04917 Y49 Sugiyama YWHAH YWHA1 AVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSIEQK
Q08J23 S593 Sugiyama NSUN2 SAKI TRM4 NNSEKMKVINTGIKVWCRNNsGEEFDCAFRLAQEGIYTLYP
Q13442 S63 Sugiyama PDAP1 HASPP28 GGDGAAGDPKKEKKsLDsDEsEDEEDDyQQKRKGVEGLIDI
Q86W56 Y832 Sugiyama PARG DDWQRRCTEIVAIDALHFRRyLDQFVPEKMRRELNKAYCGF
Q8NFD5 S1744 Sugiyama ARID1B BAF250B DAN15 KIAA1235 OSA2 ALDTINILLYDDSTVATFNLsQLSGFLELLVEYFRKCLIDI
Q96HE7 S143 Sugiyama ERO1A ERO1L UNQ434/PRO865 EANNLIEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSD
Q96HE7 T148 Sugiyama ERO1A ERO1L UNQ434/PRO865 IEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSDNFCEA
Q99640 S120 Sugiyama PKMYT1 MYT1 sRPEsFFQQsFQRLSRLGHGsyGEVFKVRSKEDGRLYAVKR
Q99640 S469 Sugiyama PKMYT1 MYT1 TVGSTStPRSRCtPRDALDLsDINsEPPRGsFPsFEPRNLL
Q99640 S479 Sugiyama PKMYT1 MYT1 RCtPRDALDLsDINsEPPRGsFPsFEPRNLLSLFEDtLDPT
Q99640 S482 Sugiyama PKMYT1 MYT1 PRDALDLsDINsEPPRGsFPsFEPRNLLSLFEDtLDPT___
Q99640 Y121 Sugiyama PKMYT1 MYT1 RPEsFFQQsFQRLSRLGHGsyGEVFKVRSKEDGRLYAVKRs
Q9NQ39 S157 Sugiyama RPS10P5 RPS10L TYRRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ_
Q9Y3U8 Y53 Sugiyama RPL36 LTKHTKFVRDMIREVCGFAPyERRAMELLKVSKDKRALKFI
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.096203e-06 5.960 0 0
Interleukin-2 family signaling R-HSA-451927 7.294484e-07 6.137 0 0
Signaling by Erythropoietin R-HSA-9006335 2.076979e-06 5.683 0 0
FGFR1 mutant receptor activation R-HSA-1839124 3.843149e-06 5.415 0 0
Uptake and function of anthrax toxins R-HSA-5210891 3.918282e-06 5.407 0 0
Downstream signal transduction R-HSA-186763 2.850172e-06 5.545 0 0
Interleukin-21 signaling R-HSA-9020958 8.543556e-06 5.068 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.388997e-05 4.857 0 0
Signaling by Interleukins R-HSA-449147 1.301006e-05 4.886 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 4.491212e-05 4.348 0 0
Cytokine Signaling in Immune system R-HSA-1280215 6.073549e-05 4.217 0 0
mRNA Splicing - Major Pathway R-HSA-72163 8.384341e-05 4.077 0 0
Erythropoietin activates STAT5 R-HSA-9027283 1.220899e-04 3.913 0 0
mRNA Splicing R-HSA-72172 1.259950e-04 3.900 0 0
Regulation of signaling by CBL R-HSA-912631 1.241750e-04 3.906 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.081783e-04 3.966 0 0
Signaling by PDGF R-HSA-186797 9.886802e-05 4.005 0 0
FLT3 Signaling R-HSA-9607240 1.562232e-04 3.806 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 2.228160e-04 3.652 0 0
Signaling by SCF-KIT R-HSA-1433557 2.063671e-04 3.685 0 0
Signaling by FGFR in disease R-HSA-1226099 2.309006e-04 3.637 0 0
Signaling by KIT in disease R-HSA-9669938 2.228160e-04 3.652 0 0
Signaling by ALK in cancer R-HSA-9700206 2.624631e-04 3.581 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 2.624631e-04 3.581 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 3.062311e-04 3.514 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 4.657529e-04 3.332 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 4.657529e-04 3.332 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 4.657529e-04 3.332 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 4.657529e-04 3.332 0 0
Interleukin-2 signaling R-HSA-9020558 4.425257e-04 3.354 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 4.318547e-04 3.365 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 7.746065e-04 3.111 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 7.746065e-04 3.111 0 0
Diseases of Cellular Senescence R-HSA-9630747 8.224180e-04 3.085 0 0
Diseases of cellular response to stress R-HSA-9675132 8.224180e-04 3.085 0 0
Erythropoietin activates RAS R-HSA-9027284 1.065262e-03 2.973 0 0
Signaling by FGFR1 amplification mutants R-HSA-1839120 1.276364e-03 2.894 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 1.825583e-03 2.739 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 1.825583e-03 2.739 0 0
MTF1 activates gene expression R-HSA-5660489 1.825583e-03 2.739 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.833665e-03 2.737 0 0
G1 Phase R-HSA-69236 2.189974e-03 2.660 0 0
Cyclin D associated events in G1 R-HSA-69231 2.189974e-03 2.660 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.359607e-03 2.627 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 2.468095e-03 2.608 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.641559e-03 2.578 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 2.878685e-03 2.541 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 3.201952e-03 2.495 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 3.186563e-03 2.497 0 0
Growth hormone receptor signaling R-HSA-982772 3.513901e-03 2.454 0 0
Interleukin-20 family signaling R-HSA-8854691 3.513901e-03 2.454 0 0
Signaling by VEGF R-HSA-194138 3.517120e-03 2.454 0 0
STAT5 Activation R-HSA-9645135 4.025237e-03 2.395 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 3.861073e-03 2.413 0 0
Interleukin-7 signaling R-HSA-1266695 4.228435e-03 2.374 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 4.616326e-03 2.336 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 4.712075e-03 2.327 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 4.936060e-03 2.307 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 5.300904e-03 2.276 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 5.906310e-03 2.229 0 0
Interleukin-23 signaling R-HSA-9020933 5.932560e-03 2.227 0 0
Interleukin-9 signaling R-HSA-8985947 5.932560e-03 2.227 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 5.932560e-03 2.227 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 6.379373e-03 2.195 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 6.550779e-03 2.184 0 0
Signaling by PTK6 R-HSA-8848021 6.550779e-03 2.184 0 0
Diseases of mitotic cell cycle R-HSA-9675126 7.391676e-03 2.131 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 8.175294e-03 2.087 0 0
Signaling by Leptin R-HSA-2586552 8.175294e-03 2.087 0 0
Drug resistance of ALK mutants R-HSA-9700649 1.025600e-02 1.989 0 0
ceritinib-resistant ALK mutants R-HSA-9717323 1.025600e-02 1.989 0 0
crizotinib-resistant ALK mutants R-HSA-9717326 1.025600e-02 1.989 0 0
NVP-TAE684-resistant ALK mutants R-HSA-9717301 1.025600e-02 1.989 0 0
lorlatinib-resistant ALK mutants R-HSA-9717329 1.025600e-02 1.989 0 0
alectinib-resistant ALK mutants R-HSA-9717316 1.025600e-02 1.989 0 0
ASP-3026-resistant ALK mutants R-HSA-9717264 1.025600e-02 1.989 0 0
brigatinib-resistant ALK mutants R-HSA-9717319 1.025600e-02 1.989 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.687304e-03 2.014 0 0
GPVI-mediated activation cascade R-HSA-114604 1.031883e-02 1.986 0 0
FLT3 signaling in disease R-HSA-9682385 1.031883e-02 1.986 0 0
Cell-Cell communication R-HSA-1500931 8.523075e-03 2.069 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 1.073912e-02 1.969 0 0
Interleukin-12 signaling R-HSA-9020591 1.158858e-02 1.936 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 1.213709e-02 1.916 0 0
Interleukin-15 signaling R-HSA-8983432 1.213709e-02 1.916 0 0
Signaling by ALK R-HSA-201556 1.235429e-02 1.908 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 1.273586e-02 1.895 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.383001e-02 1.859 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 1.429964e-02 1.845 0 0
MAPK family signaling cascades R-HSA-5683057 1.445368e-02 1.840 0 0
Signal regulatory protein family interactions R-HSA-391160 1.515667e-02 1.819 0 0
Prolactin receptor signaling R-HSA-1170546 1.515667e-02 1.819 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.543132e-02 1.812 0 0
Metabolism of RNA R-HSA-8953854 1.602536e-02 1.795 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 1.707016e-02 1.768 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.707016e-02 1.768 0 0
Interleukin-12 family signaling R-HSA-447115 1.799874e-02 1.745 0 0
Immune System R-HSA-168256 1.686118e-02 1.773 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 1.780374e-02 1.749 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.739555e-02 1.760 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.925200e-02 1.716 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 2.040745e-02 1.690 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 2.040745e-02 1.690 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 2.040745e-02 1.690 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 2.204458e-02 1.657 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 2.022050e-02 1.694 0 0
Co-stimulation by CD28 R-HSA-389356 2.069891e-02 1.684 0 0
Signaling by Hippo R-HSA-2028269 2.204458e-02 1.657 0 0
PI3K Cascade R-HSA-109704 2.265976e-02 1.645 0 0
Specification of primordial germ cells R-HSA-9827857 2.204458e-02 1.657 0 0
Response to metal ions R-HSA-5660526 2.022050e-02 1.694 0 0
FGFR1 ligand binding and activation R-HSA-190242 2.393413e-02 1.621 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 2.393413e-02 1.621 0 0
mRNA 3'-end processing R-HSA-72187 2.471837e-02 1.607 0 0
Nephrin family interactions R-HSA-373753 2.790361e-02 1.554 0 0
Formation of definitive endoderm R-HSA-9823730 2.790361e-02 1.554 0 0
Signaling by FGFR1 R-HSA-5654736 2.912835e-02 1.536 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 2.998057e-02 1.523 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 2.836843e-02 1.547 0 0
Signaling by FGFR R-HSA-190236 2.703401e-02 1.568 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 2.828207e-02 1.548 0 0
FOXO-mediated transcription R-HSA-9614085 2.782293e-02 1.556 0 0
IRS-mediated signalling R-HSA-112399 3.029164e-02 1.519 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 3.045539e-02 1.516 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 3.211708e-02 1.493 0 0
Signaling by PDGFR in disease R-HSA-9671555 3.211708e-02 1.493 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 3.211708e-02 1.493 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 3.211708e-02 1.493 0 0
Kinesins R-HSA-983189 3.392658e-02 1.469 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 3.518635e-02 1.454 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 3.518635e-02 1.454 0 0
Interleukin receptor SHC signaling R-HSA-912526 3.656307e-02 1.437 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 3.886976e-02 1.410 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 4.040089e-02 1.394 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 4.040089e-02 1.394 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 4.123044e-02 1.385 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 4.046386e-02 1.393 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 4.611802e-02 1.336 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 4.758955e-02 1.322 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 4.758955e-02 1.322 0 0
Signal Transduction R-HSA-162582 3.943263e-02 1.404 0 0
IGF1R signaling cascade R-HSA-2428924 3.910891e-02 1.408 0 0
Formation of the nephric duct R-HSA-9830364 4.123044e-02 1.385 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 4.046386e-02 1.393 0 0
Insulin receptor signalling cascade R-HSA-74751 3.910891e-02 1.408 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.364377e-02 1.360 0 0
PIP3 activates AKT signaling R-HSA-1257604 4.583288e-02 1.339 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 5.024497e-02 1.299 0 0
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336 5.024497e-02 1.299 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 5.024497e-02 1.299 0 0
MET interacts with TNS proteins R-HSA-8875513 5.024497e-02 1.299 0 0
MET activates PTPN11 R-HSA-8865999 5.024497e-02 1.299 0 0
MET activates STAT3 R-HSA-8875791 5.024497e-02 1.299 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 5.060130e-02 1.296 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 5.214124e-02 1.283 0 0
Disease R-HSA-1643685 5.368065e-02 1.270 0 0
Centrosome maturation R-HSA-380287 5.528853e-02 1.257 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 5.915728e-02 1.228 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 5.915728e-02 1.228 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 6.963301e-02 1.157 0 0
FGFR1c and Klotho ligand binding and activation R-HSA-190374 6.963301e-02 1.157 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 7.917898e-02 1.101 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 7.917898e-02 1.101 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 7.917898e-02 1.101 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 6.752303e-02 1.171 0 0
RET signaling R-HSA-8853659 7.330425e-02 1.135 0 0
MET promotes cell motility R-HSA-8875878 7.923834e-02 1.101 0 0
Signaling by MET R-HSA-6806834 6.354277e-02 1.197 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 7.917898e-02 1.101 0 0
MDK and PTN in ALK signaling R-HSA-9851151 5.998867e-02 1.222 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 6.752303e-02 1.171 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 6.752303e-02 1.171 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 6.855646e-02 1.164 0 0
Axon guidance R-HSA-422475 6.944529e-02 1.158 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 6.190353e-02 1.208 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 6.699541e-02 1.174 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 6.752303e-02 1.171 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 7.917898e-02 1.101 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 7.917898e-02 1.101 0 0
Cardiogenesis R-HSA-9733709 6.190353e-02 1.208 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 6.963301e-02 1.157 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 6.699541e-02 1.174 0 0
Bacterial Infection Pathways R-HSA-9824439 6.399504e-02 1.194 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 7.751778e-02 1.111 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 6.752303e-02 1.171 0 0
Oncogene Induced Senescence R-HSA-2559585 7.039398e-02 1.152 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 7.973290e-02 1.098 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 9.797983e-02 1.009 0 0
DAG1 core M1 glycosylations R-HSA-8932506 9.797983e-02 1.009 0 0
DAG1 core M2 glycosylations R-HSA-8932504 1.072367e-01 0.970 0 0
MET receptor recycling R-HSA-8875656 1.072367e-01 0.970 0 0
FGFR1b ligand binding and activation R-HSA-190370 1.072367e-01 0.970 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 1.072367e-01 0.970 0 0
ALK mutants bind TKIs R-HSA-9700645 1.163991e-01 0.934 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 1.254680e-01 0.901 0 0
DAG1 core M3 glycosylations R-HSA-8932505 1.344444e-01 0.871 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 1.433293e-01 0.844 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 1.433293e-01 0.844 0 0
MET activates RAS signaling R-HSA-8851805 1.521234e-01 0.818 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.779711e-01 0.750 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.947663e-01 0.710 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 1.947663e-01 0.710 0 0
Ephrin signaling R-HSA-3928664 2.112203e-01 0.675 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 8.531676e-02 1.069 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 2.193215e-01 0.659 0 0
HIV Transcription Initiation R-HSA-167161 9.153122e-02 1.038 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.153122e-02 1.038 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 9.468695e-02 1.024 0 0
Negative regulation of MET activity R-HSA-6807004 2.273400e-01 0.643 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 2.273400e-01 0.643 0 0
Translation initiation complex formation R-HSA-72649 1.347131e-01 0.871 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.417105e-01 0.849 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.667612e-01 0.778 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.667612e-01 0.778 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.777213e-01 0.750 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.109121e-01 0.955 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 8.355259e-02 1.078 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 2.030355e-01 0.692 0 0
EPH-Ephrin signaling R-HSA-2682334 8.942657e-02 1.049 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 1.043365e-01 0.982 0 0
Regulation of CDH11 function R-HSA-9762292 1.254680e-01 0.901 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.344444e-01 0.871 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 2.352767e-01 0.628 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.787371e-02 1.009 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 1.001610e-01 0.999 0 0
CD28 dependent Vav1 pathway R-HSA-389359 1.608279e-01 0.794 0 0
FGFR1c ligand binding and activation R-HSA-190373 1.608279e-01 0.794 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.153122e-02 1.038 0 0
Eukaryotic Translation Elongation R-HSA-156842 8.942657e-02 1.049 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.999505e-01 0.699 0 0
MET Receptor Activation R-HSA-6806942 8.862760e-02 1.052 0 0
Processing of SMDT1 R-HSA-8949664 1.608279e-01 0.794 0 0
Regulation of RAS by GAPs R-HSA-5658442 1.209713e-01 0.917 0 0
Co-stimulation by ICOS R-HSA-9927354 1.072367e-01 0.970 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 1.254680e-01 0.901 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 1.779711e-01 0.750 0 0
Regulation of CDH1 Function R-HSA-9764561 1.452381e-01 0.838 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.036884e-01 0.691 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.142226e-02 1.039 0 0
FCERI mediated MAPK activation R-HSA-2871796 1.372757e-01 0.862 0 0
Leishmania phagocytosis R-HSA-9664417 2.209330e-01 0.656 0 0
Parasite infection R-HSA-9664407 2.209330e-01 0.656 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 2.209330e-01 0.656 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 9.797983e-02 1.009 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 1.163991e-01 0.934 0 0
PI3K/AKT activation R-HSA-198203 1.254680e-01 0.901 0 0
Chylomicron assembly R-HSA-8963888 1.344444e-01 0.871 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 1.694435e-01 0.771 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 2.273400e-01 0.643 0 0
Co-inhibition by CTLA4 R-HSA-389513 2.273400e-01 0.643 0 0
Regulation of KIT signaling R-HSA-1433559 1.694435e-01 0.771 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 1.999505e-01 0.699 0 0
Interleukin-35 Signalling R-HSA-8984722 1.521234e-01 0.818 0 0
LDL remodeling R-HSA-8964041 9.797983e-02 1.009 0 0
VLDL clearance R-HSA-8964046 9.797983e-02 1.009 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 1.947663e-01 0.710 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 8.840749e-02 1.054 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.076107e-01 0.968 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 1.347131e-01 0.871 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.487839e-01 0.827 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.452098e-01 0.610 0 0
Mitotic Prometaphase R-HSA-68877 1.767279e-01 0.753 0 0
STING mediated induction of host immune responses R-HSA-1834941 2.193215e-01 0.659 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 1.099595e-01 0.959 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.779711e-01 0.750 0 0
Mitochondrial calcium ion transport R-HSA-8949215 2.431323e-01 0.614 0 0
Degradation of CDH1 R-HSA-9766229 1.175933e-01 0.930 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 1.521234e-01 0.818 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 1.779711e-01 0.750 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 1.779711e-01 0.750 0 0
Translation R-HSA-72766 1.845392e-01 0.734 0 0
Nervous system development R-HSA-9675108 9.554337e-02 1.020 0 0
FCERI mediated NF-kB activation R-HSA-2871837 2.344373e-01 0.630 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 1.399000e-01 0.854 0 0
Transcription of the HIV genome R-HSA-167172 1.850894e-01 0.733 0 0
Signaling by LTK in cancer R-HSA-9842640 8.862760e-02 1.052 0 0
Cholesterol biosynthesis via desmosterol R-HSA-6807047 1.344444e-01 0.871 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 1.521234e-01 0.818 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 1.521234e-01 0.818 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 1.608279e-01 0.794 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.779711e-01 0.750 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 1.779711e-01 0.750 0 0
Signaling by FGFR2 R-HSA-5654738 2.300444e-01 0.638 0 0
VLDL assembly R-HSA-8866423 8.862760e-02 1.052 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 1.344444e-01 0.871 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 1.344444e-01 0.871 0 0
Signaling by FGFR4 in disease R-HSA-5655291 1.694435e-01 0.771 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 2.431323e-01 0.614 0 0
Hedgehog ligand biogenesis R-HSA-5358346 1.243732e-01 0.905 0 0
Cilium Assembly R-HSA-5617833 1.707030e-01 0.768 0 0
GAB1 signalosome R-HSA-180292 2.112203e-01 0.675 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.074341e-01 0.683 0 0
Surfactant metabolism R-HSA-5683826 1.010905e-01 0.995 0 0
G2/M Transition R-HSA-69275 1.627865e-01 0.788 1 0
Cellular response to mitochondrial stress R-HSA-9840373 1.163991e-01 0.934 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 1.779711e-01 0.750 0 0
Carnitine synthesis R-HSA-71262 1.864118e-01 0.730 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.667277e-01 0.778 1 0
Cell Cycle, Mitotic R-HSA-69278 1.542590e-01 0.812 1 0
Frs2-mediated activation R-HSA-170968 1.608279e-01 0.794 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.578339e-01 0.802 0 0
Adherens junctions interactions R-HSA-418990 2.316532e-01 0.635 0 0
Cell junction organization R-HSA-446728 1.954699e-01 0.709 0 0
G1/S Transition R-HSA-69206 1.764372e-01 0.753 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 9.797983e-02 1.009 0 0
Suppression of apoptosis R-HSA-9635465 1.344444e-01 0.871 0 0
PECAM1 interactions R-HSA-210990 1.344444e-01 0.871 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 1.175933e-01 0.930 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 1.175933e-01 0.930 0 0
Reproduction R-HSA-1474165 1.918544e-01 0.717 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.112203e-01 0.675 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 1.101908e-01 0.958 0 0
ER to Golgi Anterograde Transport R-HSA-199977 2.426106e-01 0.615 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 1.163991e-01 0.934 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 1.694435e-01 0.771 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 1.864118e-01 0.730 0 0
Differentiation of T cells R-HSA-9945266 1.864118e-01 0.730 0 0
MAP kinase activation R-HSA-450294 1.595235e-01 0.797 0 0
Gastrulation R-HSA-9758941 9.542203e-02 1.020 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.667612e-01 0.778 0 0
Interleukin-1 signaling R-HSA-9020702 1.101908e-01 0.958 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.864118e-01 0.730 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.999505e-01 0.699 0 0
Signaling by ERBB4 R-HSA-1236394 2.074341e-01 0.683 0 0
Interleukin-17 signaling R-HSA-448424 1.925007e-01 0.716 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.163991e-01 0.934 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.521234e-01 0.818 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.030355e-01 0.692 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.030355e-01 0.692 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 2.112203e-01 0.675 0 0
Prolonged ERK activation events R-HSA-169893 1.864118e-01 0.730 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 2.431323e-01 0.614 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.072367e-01 0.970 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.163991e-01 0.934 0 0
Signaling by LTK R-HSA-9842663 1.521234e-01 0.818 0 0
TCR signaling R-HSA-202403 1.326121e-01 0.877 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.468695e-02 1.024 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.417550e-01 0.848 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.112203e-01 0.675 0 0
Signal transduction by L1 R-HSA-445144 2.273400e-01 0.643 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 1.631350e-01 0.787 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 2.352767e-01 0.628 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 2.352767e-01 0.628 0 0
Kidney development R-HSA-9830369 1.813996e-01 0.741 0 0
Cellular Senescence R-HSA-2559583 1.511754e-01 0.821 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.123620e-01 0.949 0 0
Tie2 Signaling R-HSA-210993 2.112203e-01 0.675 0 0
Formation of paraxial mesoderm R-HSA-9793380 1.595235e-01 0.797 0 0
PI Metabolism R-HSA-1483255 1.123620e-01 0.949 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.142400e-01 0.942 0 0
Infectious disease R-HSA-5663205 2.313940e-01 0.636 0 0
Signaling by EGFR R-HSA-177929 1.417105e-01 0.849 0 0
Signaling by Insulin receptor R-HSA-74752 8.942657e-02 1.049 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 1.947663e-01 0.710 0 0
tRNA Aminoacylation R-HSA-379724 1.559273e-01 0.807 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 1.277979e-01 0.893 0 0
MHC class II antigen presentation R-HSA-2132295 1.688653e-01 0.772 0 0
Apoptotic execution phase R-HSA-75153 1.076107e-01 0.968 0 0
Intracellular signaling by second messengers R-HSA-9006925 8.231164e-02 1.085 0 0
Apoptosis R-HSA-109581 1.167222e-01 0.933 0 0
Programmed Cell Death R-HSA-5357801 2.036310e-01 0.691 0 0
S Phase R-HSA-69242 2.453457e-01 0.610 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 2.490082e-01 0.604 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 2.493534e-01 0.603 0 0
FGFR2 alternative splicing R-HSA-6803529 2.509077e-01 0.600 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 2.509077e-01 0.600 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 2.509077e-01 0.600 0 0
LDL clearance R-HSA-8964038 2.509077e-01 0.600 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 2.528086e-01 0.597 0 0
Membrane Trafficking R-HSA-199991 2.544597e-01 0.594 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 2.563338e-01 0.591 0 0
Interleukin-1 family signaling R-HSA-446652 2.563338e-01 0.591 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.566105e-01 0.591 0 0
XBP1(S) activates chaperone genes R-HSA-381038 2.566105e-01 0.591 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.586037e-01 0.587 0 0
Formation of the ureteric bud R-HSA-9830674 2.586037e-01 0.587 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.586037e-01 0.587 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 2.662211e-01 0.575 0 0
Plasma lipoprotein assembly R-HSA-8963898 2.662211e-01 0.575 0 0
Complex III assembly R-HSA-9865881 2.662211e-01 0.575 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 2.662211e-01 0.575 0 0
ER-Phagosome pathway R-HSA-1236974 2.680209e-01 0.572 0 0
Downstream TCR signaling R-HSA-202424 2.718246e-01 0.566 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 2.737608e-01 0.563 0 0
Sema4D in semaphorin signaling R-HSA-400685 2.737608e-01 0.563 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 2.737608e-01 0.563 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 2.737608e-01 0.563 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 2.756278e-01 0.560 0 0
IRE1alpha activates chaperones R-HSA-381070 2.794299e-01 0.554 0 0
MET activates PTK2 signaling R-HSA-8874081 2.812234e-01 0.551 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 2.812234e-01 0.551 0 0
Signaling by EGFR in Cancer R-HSA-1643713 2.812234e-01 0.551 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 2.812234e-01 0.551 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 2.812234e-01 0.551 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 2.812234e-01 0.551 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 2.832308e-01 0.548 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 2.886097e-01 0.540 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 2.886097e-01 0.540 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 2.886097e-01 0.540 0 0
Signaling by FGFR3 in disease R-HSA-5655332 2.886097e-01 0.540 0 0
Insulin processing R-HSA-264876 2.886097e-01 0.540 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 2.886097e-01 0.540 0 0
Maturation of hRSV A proteins R-HSA-9828806 2.886097e-01 0.540 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 2.959207e-01 0.529 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 2.959207e-01 0.529 0 0
Formation of a pool of free 40S subunits R-HSA-72689 2.984138e-01 0.525 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 3.022026e-01 0.520 0 0
COPI-mediated anterograde transport R-HSA-6807878 3.022026e-01 0.520 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 3.022026e-01 0.520 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 3.031569e-01 0.518 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.031569e-01 0.518 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 3.031569e-01 0.518 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 3.031569e-01 0.518 0 0
DARPP-32 events R-HSA-180024 3.031569e-01 0.518 0 0
Cell-cell junction organization R-HSA-421270 3.062513e-01 0.514 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 3.097697e-01 0.509 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 3.097697e-01 0.509 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 3.097697e-01 0.509 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 3.103192e-01 0.508 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 3.103192e-01 0.508 0 0
DAP12 signaling R-HSA-2424491 3.103192e-01 0.508 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 3.103192e-01 0.508 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 3.120607e-01 0.506 0 0
RNA Polymerase II Transcription R-HSA-73857 3.142015e-01 0.503 0 0
Cellular responses to stimuli R-HSA-8953897 3.165449e-01 0.500 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 3.174084e-01 0.498 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 3.174084e-01 0.498 0 0
EGFR downregulation R-HSA-182971 3.174084e-01 0.498 0 0
Innate Immune System R-HSA-168249 3.175935e-01 0.498 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 3.176726e-01 0.498 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 3.176726e-01 0.498 0 0
Ub-specific processing proteases R-HSA-5689880 3.176726e-01 0.498 0 0
DAG1 glycosylations R-HSA-8931838 3.244251e-01 0.489 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 3.244251e-01 0.489 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 3.313701e-01 0.480 0 0
Nuclear RNA decay R-HSA-9930044 3.313701e-01 0.480 0 0
Developmental Cell Lineages R-HSA-9734767 3.340862e-01 0.476 0 0
Vpu mediated degradation of CD4 R-HSA-180534 3.382441e-01 0.471 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 3.382441e-01 0.471 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 3.382441e-01 0.471 0 0
Cell Cycle R-HSA-1640170 3.385051e-01 0.470 1 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 3.398507e-01 0.469 0 0
SARS-CoV-1-host interactions R-HSA-9692914 3.435849e-01 0.464 0 0
eNOS activation R-HSA-203615 3.450479e-01 0.462 0 0
Mitophagy R-HSA-5205647 3.450479e-01 0.462 0 0
NOD1/2 Signaling Pathway R-HSA-168638 3.450479e-01 0.462 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 3.450479e-01 0.462 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 3.510331e-01 0.455 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 3.510331e-01 0.455 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 3.510331e-01 0.455 0 0
Antigen processing-Cross presentation R-HSA-1236975 3.510331e-01 0.455 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 3.510331e-01 0.455 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 3.517821e-01 0.454 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 3.517821e-01 0.454 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 3.517821e-01 0.454 0 0
Regulation of Apoptosis R-HSA-169911 3.517821e-01 0.454 0 0
Signalling to ERKs R-HSA-187687 3.517821e-01 0.454 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 3.547466e-01 0.450 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 3.584475e-01 0.446 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 3.584475e-01 0.446 0 0
RUNX2 regulates bone development R-HSA-8941326 3.584475e-01 0.446 0 0
Triglyceride catabolism R-HSA-163560 3.584475e-01 0.446 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 3.584527e-01 0.446 0 0
MyD88-independent TLR4 cascade R-HSA-166166 3.584527e-01 0.446 0 0
Platelet activation, signaling and aggregation R-HSA-76002 3.597122e-01 0.444 0 0
Degradation of DVL R-HSA-4641258 3.650448e-01 0.438 0 0
Degradation of AXIN R-HSA-4641257 3.650448e-01 0.438 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 3.650448e-01 0.438 0 0
Metabolism of folate and pterines R-HSA-196757 3.650448e-01 0.438 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 3.658417e-01 0.437 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 3.658417e-01 0.437 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 3.695242e-01 0.432 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 3.715747e-01 0.430 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 3.715747e-01 0.430 0 0
Developmental Biology R-HSA-1266738 3.765417e-01 0.424 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 3.780378e-01 0.422 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 3.780378e-01 0.422 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 3.780378e-01 0.422 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 3.780378e-01 0.422 0 0
Stabilization of p53 R-HSA-69541 3.780378e-01 0.422 0 0
Plasma lipoprotein clearance R-HSA-8964043 3.780378e-01 0.422 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 3.780378e-01 0.422 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 3.805207e-01 0.420 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 3.820559e-01 0.418 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 3.841686e-01 0.415 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 3.844348e-01 0.415 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 3.844348e-01 0.415 0 0
Generation of second messenger molecules R-HSA-202433 3.844348e-01 0.415 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 3.844348e-01 0.415 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 3.844348e-01 0.415 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 3.844348e-01 0.415 0 0
Cap-dependent Translation Initiation R-HSA-72737 3.878073e-01 0.411 0 0
Eukaryotic Translation Initiation R-HSA-72613 3.878073e-01 0.411 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 3.907664e-01 0.408 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 3.907664e-01 0.408 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 3.907664e-01 0.408 0 0
Degradation of CRY and PER proteins R-HSA-9932298 3.970333e-01 0.401 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 3.970333e-01 0.401 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 3.970333e-01 0.401 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 3.970333e-01 0.401 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 3.986665e-01 0.399 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 3.986665e-01 0.399 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 3.986836e-01 0.399 0 0
Signaling by ROBO receptors R-HSA-376176 4.014438e-01 0.396 0 0
M Phase R-HSA-68886 4.016681e-01 0.396 0 0
Signaling by FGFR4 R-HSA-5654743 4.093755e-01 0.388 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 4.093755e-01 0.388 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 4.093755e-01 0.388 0 0
Response of Mtb to phagocytosis R-HSA-9637690 4.093755e-01 0.388 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 4.094366e-01 0.388 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 4.094366e-01 0.388 0 0
Proteasome assembly R-HSA-9907900 4.154521e-01 0.381 0 0
RMTs methylate histone arginines R-HSA-3214858 4.154521e-01 0.381 0 0
DAP12 interactions R-HSA-2172127 4.154521e-01 0.381 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 4.154521e-01 0.381 0 0
Formation of the cornified envelope R-HSA-6809371 4.165647e-01 0.380 0 0
Signaling by FGFR3 R-HSA-5654741 4.214666e-01 0.375 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 4.214666e-01 0.375 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 4.214666e-01 0.375 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 4.214666e-01 0.375 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 4.214666e-01 0.375 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 4.214666e-01 0.375 0 0
Somitogenesis R-HSA-9824272 4.214666e-01 0.375 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 4.274195e-01 0.369 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 4.274195e-01 0.369 0 0
Regulation of pyruvate metabolism R-HSA-9861718 4.274195e-01 0.369 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 4.333115e-01 0.363 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 4.333115e-01 0.363 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 4.341942e-01 0.362 0 0
Plasma lipoprotein remodeling R-HSA-8963899 4.391433e-01 0.357 0 0
Hemostasis R-HSA-109582 4.500836e-01 0.347 0 0
Signaling by FGFR2 in disease R-HSA-5655253 4.506285e-01 0.346 0 0
Azathioprine ADME R-HSA-9748787 4.506285e-01 0.346 0 0
Circadian clock R-HSA-9909396 4.515370e-01 0.345 0 0
Meiotic recombination R-HSA-912446 4.562831e-01 0.341 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 4.562831e-01 0.341 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 4.562831e-01 0.341 0 0
Generic Transcription Pathway R-HSA-212436 4.564472e-01 0.341 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 4.618799e-01 0.335 0 0
Orc1 removal from chromatin R-HSA-68949 4.618799e-01 0.335 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 4.618799e-01 0.335 0 0
Neurexins and neuroligins R-HSA-6794361 4.618799e-01 0.335 0 0
Organelle biogenesis and maintenance R-HSA-1852241 4.655925e-01 0.332 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 4.674194e-01 0.330 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 4.674194e-01 0.330 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 4.674194e-01 0.330 0 0
Regulation of PTEN stability and activity R-HSA-8948751 4.674194e-01 0.330 0 0
HIV Infection R-HSA-162906 4.690625e-01 0.329 0 0
SARS-CoV-2-host interactions R-HSA-9705683 4.717011e-01 0.326 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 4.719475e-01 0.326 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 4.729022e-01 0.325 0 0
Ribosome-associated quality control R-HSA-9948299 4.753053e-01 0.323 0 0
Signaling by Hedgehog R-HSA-5358351 4.753053e-01 0.323 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 4.783289e-01 0.320 0 0
Unfolded Protein Response (UPR) R-HSA-381119 4.786502e-01 0.320 0 0
NRAGE signals death through JNK R-HSA-193648 4.837001e-01 0.315 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 4.837001e-01 0.315 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 4.837001e-01 0.315 0 0
TNF signaling R-HSA-75893 4.837001e-01 0.315 0 0
Vesicle-mediated transport R-HSA-5653656 4.851655e-01 0.314 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 4.853011e-01 0.314 0 0
Dectin-2 family R-HSA-5621480 4.890162e-01 0.311 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 4.890162e-01 0.311 0 0
Late Phase of HIV Life Cycle R-HSA-162599 4.918996e-01 0.308 0 0
ESR-mediated signaling R-HSA-8939211 4.951762e-01 0.305 0 0
Clathrin-mediated endocytosis R-HSA-8856828 4.951790e-01 0.305 0 0
Metabolism of non-coding RNA R-HSA-194441 4.994860e-01 0.301 0 0
snRNP Assembly R-HSA-191859 4.994860e-01 0.301 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 4.994860e-01 0.301 0 0
Triglyceride metabolism R-HSA-8979227 4.994860e-01 0.301 0 0
Signaling by ERBB2 R-HSA-1227986 5.046406e-01 0.297 0 0
Metabolism of polyamines R-HSA-351202 5.046406e-01 0.297 0 0
Cellular responses to stress R-HSA-2262752 5.080528e-01 0.294 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 5.097424e-01 0.293 0 0
Endogenous sterols R-HSA-211976 5.097424e-01 0.293 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 5.113744e-01 0.291 0 0
Signaling by NTRKs R-HSA-166520 5.113744e-01 0.291 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 5.147920e-01 0.288 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 5.147920e-01 0.288 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 5.147920e-01 0.288 0 0
Mitochondrial protein import R-HSA-1268020 5.147920e-01 0.288 0 0
NCAM signaling for neurite out-growth R-HSA-375165 5.147920e-01 0.288 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 5.147920e-01 0.288 0 0
MITF-M-dependent gene expression R-HSA-9856651 5.177573e-01 0.286 0 0
Complex I biogenesis R-HSA-6799198 5.197899e-01 0.284 0 0
Semaphorin interactions R-HSA-373755 5.197899e-01 0.284 0 0
CD22 mediated BCR regulation R-HSA-5690714 5.247367e-01 0.280 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 5.247367e-01 0.280 0 0
Xenobiotics R-HSA-211981 5.247367e-01 0.280 0 0
Cellular response to hypoxia R-HSA-1234174 5.296327e-01 0.276 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 5.303572e-01 0.275 0 0
Death Receptor Signaling R-HSA-73887 5.303572e-01 0.275 0 0
HIV Life Cycle R-HSA-162587 5.396605e-01 0.268 0 0
Deubiquitination R-HSA-5688426 5.405155e-01 0.267 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 5.440222e-01 0.264 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 5.440222e-01 0.264 0 0
Adaptive Immune System R-HSA-1280218 5.441391e-01 0.264 0 0
Interferon gamma signaling R-HSA-877300 5.457921e-01 0.263 0 0
Cell Cycle Checkpoints R-HSA-69620 5.478458e-01 0.261 1 0
Regulation of TP53 Activity R-HSA-5633007 5.488367e-01 0.261 0 0
Neutrophil degranulation R-HSA-6798695 5.491899e-01 0.260 0 0
COPII-mediated vesicle transport R-HSA-204005 5.533712e-01 0.257 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 5.533712e-01 0.257 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 5.533712e-01 0.257 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 5.579740e-01 0.253 0 0
Regulation of mitotic cell cycle R-HSA-453276 5.579740e-01 0.253 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 5.579740e-01 0.253 0 0
ECM proteoglycans R-HSA-3000178 5.579740e-01 0.253 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 5.579740e-01 0.253 0 0
Metabolism of cofactors R-HSA-8978934 5.579740e-01 0.253 0 0
Hedgehog 'on' state R-HSA-5632684 5.579740e-01 0.253 0 0
Separation of Sister Chromatids R-HSA-2467813 5.608726e-01 0.251 0 0
Switching of origins to a post-replicative state R-HSA-69052 5.670387e-01 0.246 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 5.670387e-01 0.246 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 5.670387e-01 0.246 0 0
Signaling by NOTCH4 R-HSA-9013694 5.715014e-01 0.243 0 0
ROS and RNS production in phagocytes R-HSA-1222556 5.715014e-01 0.243 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 5.759185e-01 0.240 0 0
ISG15 antiviral mechanism R-HSA-1169408 5.759185e-01 0.240 0 0
UCH proteinases R-HSA-5689603 5.802903e-01 0.236 0 0
Gene expression (Transcription) R-HSA-74160 5.834730e-01 0.234 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 5.871136e-01 0.231 0 0
Nuclear Receptor transcription pathway R-HSA-383280 5.889000e-01 0.230 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 5.889000e-01 0.230 0 0
Cholesterol biosynthesis R-HSA-191273 5.889000e-01 0.230 0 0
G alpha (12/13) signalling events R-HSA-416482 5.889000e-01 0.230 0 0
ABC transporter disorders R-HSA-5619084 5.889000e-01 0.230 0 0
PCP/CE pathway R-HSA-4086400 5.889000e-01 0.230 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 5.931387e-01 0.227 0 0
SARS-CoV-1 Infection R-HSA-9678108 5.956008e-01 0.225 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 5.973340e-01 0.224 0 0
PKR-mediated signaling R-HSA-9833482 5.973340e-01 0.224 0 0
Interferon Signaling R-HSA-913531 6.007958e-01 0.221 0 0
Leishmania infection R-HSA-9658195 6.017154e-01 0.221 0 0
Parasitic Infection Pathways R-HSA-9824443 6.017154e-01 0.221 0 0
Respiratory electron transport R-HSA-611105 6.039578e-01 0.219 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 6.096637e-01 0.215 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 6.136897e-01 0.212 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 6.136897e-01 0.212 0 0
Meiosis R-HSA-1500620 6.176743e-01 0.209 0 0
Protein-protein interactions at synapses R-HSA-6794362 6.176743e-01 0.209 0 0
Amplification of signal from the kinetochores R-HSA-141424 6.216181e-01 0.206 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 6.216181e-01 0.206 0 0
Pyruvate metabolism R-HSA-70268 6.293848e-01 0.201 0 0
Phospholipid metabolism R-HSA-1483257 6.323902e-01 0.199 0 0
Peptide chain elongation R-HSA-156902 6.332085e-01 0.198 0 0
Selective autophagy R-HSA-9663891 6.332085e-01 0.198 0 0
Toll-like Receptor Cascades R-HSA-168898 6.386693e-01 0.195 0 0
Viral Infection Pathways R-HSA-9824446 6.425163e-01 0.192 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 6.444459e-01 0.191 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 6.481152e-01 0.188 0 0
FCGR activation R-HSA-2029481 6.553411e-01 0.184 0 0
Assembly of the pre-replicative complex R-HSA-68867 6.553411e-01 0.184 0 0
Collagen formation R-HSA-1474290 6.588986e-01 0.181 0 0
Co-inhibition by PD-1 R-HSA-389948 6.612816e-01 0.180 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 6.624195e-01 0.179 0 0
Eukaryotic Translation Termination R-HSA-72764 6.659044e-01 0.177 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 6.659044e-01 0.177 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 6.693534e-01 0.174 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 6.727671e-01 0.172 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 6.727671e-01 0.172 0 0
Post-translational protein phosphorylation R-HSA-8957275 6.761458e-01 0.170 0 0
Keratinization R-HSA-6805567 6.780784e-01 0.169 0 0
HATs acetylate histones R-HSA-3214847 6.794897e-01 0.168 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 6.794897e-01 0.168 0 0
Mitotic Spindle Checkpoint R-HSA-69618 6.827994e-01 0.166 0 0
Hedgehog 'off' state R-HSA-5610787 6.827994e-01 0.166 0 0
ABC-family proteins mediated transport R-HSA-382556 6.827994e-01 0.166 0 0
Selenocysteine synthesis R-HSA-2408557 6.860750e-01 0.164 0 0
Viral mRNA Translation R-HSA-192823 6.925259e-01 0.160 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 6.941953e-01 0.159 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 6.957017e-01 0.158 0 0
Response of endothelial cells to shear stress R-HSA-9860931 6.957017e-01 0.158 0 0
Opioid Signalling R-HSA-111885 6.957017e-01 0.158 0 0
RSV-host interactions R-HSA-9833110 6.988449e-01 0.156 0 0
Mitotic Anaphase R-HSA-68882 7.008975e-01 0.154 0 0
Nucleotide Excision Repair R-HSA-5696398 7.019558e-01 0.154 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 7.031045e-01 0.153 0 0
Platelet homeostasis R-HSA-418346 7.050348e-01 0.152 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 7.080822e-01 0.150 0 0
Synthesis of DNA R-HSA-69239 7.080822e-01 0.150 0 0
SARS-CoV Infections R-HSA-9679506 7.113511e-01 0.148 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 7.140834e-01 0.146 0 0
DNA Replication Pre-Initiation R-HSA-69002 7.140834e-01 0.146 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 7.214409e-01 0.142 0 0
Inositol phosphate metabolism R-HSA-1483249 7.228560e-01 0.141 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 7.285553e-01 0.138 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 7.313610e-01 0.136 0 0
SARS-CoV-2 Infection R-HSA-9694516 7.350974e-01 0.134 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 7.368864e-01 0.133 0 0
Chromatin modifying enzymes R-HSA-3247509 7.386001e-01 0.132 0 0
L1CAM interactions R-HSA-373760 7.396066e-01 0.131 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 7.406761e-01 0.130 0 0
Peptide hormone metabolism R-HSA-2980736 7.422988e-01 0.129 0 0
Cell surface interactions at the vascular wall R-HSA-202733 7.444769e-01 0.128 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 7.527938e-01 0.123 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 7.527938e-01 0.123 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 7.527938e-01 0.123 0 0
Signaling by Nuclear Receptors R-HSA-9006931 7.577281e-01 0.120 0 0
Host Interactions of HIV factors R-HSA-162909 7.603852e-01 0.119 0 0
Chromatin organization R-HSA-4839726 7.668705e-01 0.115 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 7.677449e-01 0.115 0 0
Platelet degranulation R-HSA-114608 7.701478e-01 0.113 0 0
G2/M Checkpoints R-HSA-69481 7.701478e-01 0.113 1 0
Adipogenesis R-HSA-9843745 7.817969e-01 0.107 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 7.862904e-01 0.104 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 7.887428e-01 0.103 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 7.950035e-01 0.100 0 0
O-linked glycosylation R-HSA-5173105 7.971260e-01 0.098 0 0
Cellular response to chemical stress R-HSA-9711123 7.988575e-01 0.098 0 0
PTEN Regulation R-HSA-6807070 8.013057e-01 0.096 0 0
Macroautophagy R-HSA-1632852 8.053998e-01 0.094 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 8.094100e-01 0.092 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 8.113842e-01 0.091 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.198933e-01 0.086 0 0
Potential therapeutics for SARS R-HSA-9679191 8.246460e-01 0.084 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 8.264633e-01 0.083 0 0
Arachidonate metabolism R-HSA-2142753 8.282619e-01 0.082 0 0
DNA Replication R-HSA-69306 8.300419e-01 0.081 0 0
Protein localization R-HSA-9609507 8.300419e-01 0.081 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 8.335472e-01 0.079 0 0
PPARA activates gene expression R-HSA-1989781 8.335472e-01 0.079 0 0
Autophagy R-HSA-9612973 8.352728e-01 0.078 0 0
HCMV Late Events R-HSA-9610379 8.369806e-01 0.077 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.369806e-01 0.077 0 0
Asparagine N-linked glycosylation R-HSA-446203 8.376485e-01 0.077 0 0
Cellular response to starvation R-HSA-9711097 8.386708e-01 0.076 0 0
Signaling by TGFB family members R-HSA-9006936 8.419991e-01 0.075 0 0
Selenoamino acid metabolism R-HSA-2408522 8.484524e-01 0.071 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 8.531197e-01 0.069 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 8.591214e-01 0.066 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 8.634621e-01 0.064 0 0
Leishmania parasite growth and survival R-HSA-9664433 8.634621e-01 0.064 0 0
Influenza Infection R-HSA-168255 8.717486e-01 0.060 0 0
TCF dependent signaling in response to WNT R-HSA-201681 8.769932e-01 0.057 0 0
Diseases of glycosylation R-HSA-3781865 8.782707e-01 0.056 0 0
Extracellular matrix organization R-HSA-1474244 8.788842e-01 0.056 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 8.832502e-01 0.054 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.080084e-01 0.042 0 0
Drug ADME R-HSA-9748784 9.155645e-01 0.038 0 0
Neddylation R-HSA-8951664 9.181740e-01 0.037 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.255311e-01 0.034 0 0
Metabolism of proteins R-HSA-392499 9.265972e-01 0.033 0 0
rRNA processing R-HSA-72312 9.270746e-01 0.033 0 0
Signaling by NOTCH R-HSA-157118 9.329368e-01 0.030 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.376805e-01 0.028 0 0
HCMV Infection R-HSA-9609646 9.396099e-01 0.027 0 0
Diseases of metabolism R-HSA-5668914 9.468403e-01 0.024 0 0
G alpha (q) signalling events R-HSA-416476 9.478576e-01 0.023 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.549848e-01 0.020 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.623593e-01 0.017 0 0
Signaling by WNT R-HSA-195721 9.635184e-01 0.016 0 0
Post-translational protein modification R-HSA-597592 9.653490e-01 0.015 0 0
Metabolism of steroids R-HSA-8957322 9.722522e-01 0.012 0 0
DNA Repair R-HSA-73894 9.810176e-01 0.008 0 0
G alpha (i) signalling events R-HSA-418594 9.885732e-01 0.005 0 0
Fatty acid metabolism R-HSA-8978868 9.885732e-01 0.005 0 0
GPCR downstream signalling R-HSA-388396 9.895786e-01 0.005 0 0
Transport of small molecules R-HSA-382551 9.932026e-01 0.003 0 0
Neuronal System R-HSA-112316 9.940183e-01 0.003 0 0
Signaling by GPCR R-HSA-372790 9.949057e-01 0.002 0 0
Metabolism of lipids R-HSA-556833 9.960842e-01 0.002 0 0
Biological oxidations R-HSA-211859 9.966701e-01 0.001 0 0
Metabolism R-HSA-1430728 9.999999e-01 0.000 0 0
Polo-like kinase mediated events R-HSA-156711 1.000000e+00 0.000 1 1
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.000000e+00 0.000 1 1
G2/M DNA replication checkpoint R-HSA-69478 1.000000e+00 0.000 1 1
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Attenuation phase R-HSA-3371568 1.110223e-16 15.955 0 0
HSF1 activation R-HSA-3371511 1.110223e-16 15.955 0 0
HSF1-dependent transactivation R-HSA-3371571 1.110223e-16 15.955 0 0
Cellular response to heat stress R-HSA-3371556 1.110223e-16 15.955 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.110223e-16 15.955 0 0
Cellular responses to stimuli R-HSA-8953897 1.298961e-14 13.886 0 0
Cellular responses to stress R-HSA-2262752 7.993606e-14 13.097 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 7.325252e-13 12.135 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 2.048839e-11 10.688 0 0
Activation of BH3-only proteins R-HSA-114452 3.712053e-11 10.430 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 4.445029e-10 9.352 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.128443e-09 8.948 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 2.198329e-09 8.658 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 5.046032e-09 8.297 0 0
Apoptosis R-HSA-109581 2.037378e-08 7.691 0 0
G2/M Checkpoints R-HSA-69481 1.136652e-07 6.944 1 0
Programmed Cell Death R-HSA-5357801 1.354086e-07 6.868 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 2.393156e-07 6.621 0 0
G2/M Transition R-HSA-69275 6.844318e-07 6.165 1 0
Mitotic G2-G2/M phases R-HSA-453274 7.844995e-07 6.105 1 0
Axon guidance R-HSA-422475 8.016395e-07 6.096 0 0
Nervous system development R-HSA-9675108 2.991893e-06 5.524 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.532776e-05 4.815 0 0
Cell Cycle R-HSA-1640170 2.144662e-05 4.669 1 0
TP53 Regulates Metabolic Genes R-HSA-5628897 2.657642e-05 4.576 0 0
PKR-mediated signaling R-HSA-9833482 2.554100e-05 4.593 0 0
Cell Cycle Checkpoints R-HSA-69620 4.073881e-05 4.390 1 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 4.721638e-05 4.326 0 0
Membrane Trafficking R-HSA-199991 5.645291e-05 4.248 0 0
Signaling by VEGF R-HSA-194138 6.214030e-05 4.207 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 6.479122e-05 4.188 0 0
Signaling by ALK in cancer R-HSA-9700206 6.479122e-05 4.188 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 6.957511e-05 4.158 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 7.638029e-05 4.117 0 0
G2/M DNA damage checkpoint R-HSA-69473 8.373645e-05 4.077 0 0
Centrosome maturation R-HSA-380287 9.167858e-05 4.038 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 9.040742e-05 4.044 0 0
FLT3 Signaling R-HSA-9607240 9.283628e-05 4.032 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.127350e-04 3.948 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.305249e-04 3.884 0 0
L1CAM interactions R-HSA-373760 1.394633e-04 3.856 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.573471e-04 3.803 0 0
SARS-CoV-2 Infection R-HSA-9694516 1.698481e-04 3.770 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.924579e-04 3.716 0 0
Cell Cycle, Mitotic R-HSA-69278 1.925013e-04 3.716 1 0
Recycling pathway of L1 R-HSA-437239 2.121544e-04 3.673 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 2.363707e-04 3.626 0 0
G1/S Transition R-HSA-69206 2.614084e-04 3.583 0 0
Viral Infection Pathways R-HSA-9824446 2.659612e-04 3.575 0 0
SARS-CoV-1-host interactions R-HSA-9692914 2.746429e-04 3.561 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.879567e-04 3.541 0 0
Selective autophagy R-HSA-9663891 2.879567e-04 3.541 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 3.163748e-04 3.500 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 3.513270e-04 3.454 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 3.814990e-04 3.419 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 3.705336e-04 3.431 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 4.270986e-04 3.369 0 0
Autophagy R-HSA-9612973 4.457406e-04 3.351 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 5.352908e-04 3.271 0 0
Aggrephagy R-HSA-9646399 5.886344e-04 3.230 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 6.315540e-04 3.200 0 0
Cilium Assembly R-HSA-5617833 6.788282e-04 3.168 0 0
Macroautophagy R-HSA-1632852 7.068421e-04 3.151 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 7.933921e-04 3.101 0 0
Metabolism of RNA R-HSA-8953854 8.814022e-04 3.055 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 9.502498e-04 3.022 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 9.502498e-04 3.022 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 9.379426e-04 3.028 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 9.177495e-04 3.037 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 9.524867e-04 3.021 0 0
Vesicle-mediated transport R-HSA-5653656 1.032684e-03 2.986 0 0
S Phase R-HSA-69242 1.048583e-03 2.979 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.152547e-03 2.938 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.131125e-03 2.946 0 0
Signaling by ROBO receptors R-HSA-376176 1.165135e-03 2.934 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.203008e-03 2.920 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.207629e-03 2.918 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.312396e-03 2.882 0 0
Interferon Signaling R-HSA-913531 1.315036e-03 2.881 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.386022e-03 2.858 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.485025e-03 2.828 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.622891e-03 2.790 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.618702e-03 2.791 0 0
Switching of origins to a post-replicative state R-HSA-69052 1.997886e-03 2.699 0 0
Orc1 removal from chromatin R-HSA-68949 2.025545e-03 2.693 0 0
Ribosome-associated quality control R-HSA-9948299 2.118020e-03 2.674 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 2.191330e-03 2.659 0 0
Regulation of PTEN stability and activity R-HSA-8948751 2.197718e-03 2.658 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 2.302977e-03 2.638 0 0
Mitotic Prometaphase R-HSA-68877 2.344005e-03 2.630 0 0
Regulation of TP53 Degradation R-HSA-6804757 2.508863e-03 2.601 0 0
CASP4 inflammasome assembly R-HSA-9948001 2.882488e-03 2.540 0 0
FOXO-mediated transcription R-HSA-9614085 2.826371e-03 2.549 0 0
Hedgehog 'off' state R-HSA-5610787 2.984112e-03 2.525 0 0
Immune System R-HSA-168256 3.155196e-03 2.501 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 3.338624e-03 2.476 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.713156e-03 2.430 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 3.440469e-03 2.463 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 3.654465e-03 2.437 0 0
Kinesins R-HSA-983189 3.729479e-03 2.428 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 3.544219e-03 2.450 0 0
SARS-CoV Infections R-HSA-9679506 3.447959e-03 2.462 0 0
Neutrophil degranulation R-HSA-6798695 3.753467e-03 2.426 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 3.991177e-03 2.399 0 0
Cellular response to chemical stress R-HSA-9711123 4.122537e-03 2.385 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 4.182640e-03 2.379 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 4.241086e-03 2.373 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 4.285050e-03 2.368 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 4.732338e-03 2.325 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 5.127627e-03 2.290 0 0
Microbial factors inhibit CASP4 activity R-HSA-9956593 6.055142e-03 2.218 0 0
Somitogenesis R-HSA-9824272 6.013650e-03 2.221 0 0
Infectious disease R-HSA-5663205 6.234213e-03 2.205 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 6.459402e-03 2.190 0 0
Late endosomal microautophagy R-HSA-9615710 7.134940e-03 2.147 0 0
mRNA Splicing - Major Pathway R-HSA-72163 6.812908e-03 2.167 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 7.564409e-03 2.121 0 0
Regulation of mitotic cell cycle R-HSA-453276 7.564409e-03 2.121 0 0
Eukaryotic Translation Elongation R-HSA-156842 6.898363e-03 2.161 0 0
Eukaryotic Translation Initiation R-HSA-72613 7.497942e-03 2.125 0 0
Cap-dependent Translation Initiation R-HSA-72737 7.497942e-03 2.125 0 0
MTF1 activates gene expression R-HSA-5660489 7.526772e-03 2.123 0 0
EPH-Ephrin signaling R-HSA-2682334 6.898363e-03 2.161 0 0
Signaling by Hedgehog R-HSA-5358351 6.763912e-03 2.170 0 0
Developmental Biology R-HSA-1266738 7.185293e-03 2.144 0 0
Non-canonical inflammasome activation R-HSA-9686114 7.076583e-03 2.150 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 7.855524e-03 2.105 0 0
Protein methylation R-HSA-8876725 8.194130e-03 2.086 0 0
Formation of a pool of free 40S subunits R-HSA-72689 8.410994e-03 2.075 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 8.410994e-03 2.075 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 8.622329e-03 2.064 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 9.129559e-03 2.040 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 9.129559e-03 2.040 0 0
mRNA Splicing R-HSA-72172 9.678881e-03 2.014 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.029907e-02 1.987 1 1
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 1.072493e-02 1.970 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.015459e-02 1.993 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.029907e-02 1.987 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 9.762638e-03 2.010 0 0
G-protein beta:gamma signalling R-HSA-397795 1.029907e-02 1.987 0 0
Interleukin-1 signaling R-HSA-9020702 1.111888e-02 1.954 0 0
Influenza Infection R-HSA-168255 1.112881e-02 1.954 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 1.130163e-02 1.947 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.183153e-02 1.927 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 1.214124e-02 1.916 0 0
Phosphorylation of Emi1 R-HSA-176417 1.301182e-02 1.886 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 1.318746e-02 1.880 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.327159e-02 1.877 0 0
Regulation of CDH1 Function R-HSA-9764561 1.360304e-02 1.866 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.365981e-02 1.865 0 0
G2/M DNA replication checkpoint R-HSA-69478 1.623997e-02 1.789 1 1
Adherens junctions interactions R-HSA-418990 1.457635e-02 1.836 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.564616e-02 1.806 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.629204e-02 1.788 0 0
Ovarian tumor domain proteases R-HSA-5689896 1.537280e-02 1.813 0 0
Synthesis of DNA R-HSA-69239 1.501868e-02 1.823 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.623997e-02 1.789 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.592712e-02 1.798 0 0
Nef and signal transduction R-HSA-164944 1.623997e-02 1.789 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 1.658179e-02 1.780 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.700733e-02 1.769 0 0
Formation of paraxial mesoderm R-HSA-9793380 1.713532e-02 1.766 0 0
Separation of Sister Chromatids R-HSA-2467813 1.759630e-02 1.755 0 0
Post NMDA receptor activation events R-HSA-438064 1.812578e-02 1.742 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.860236e-02 1.730 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.891168e-02 1.723 0 0
Peptide chain elongation R-HSA-156902 1.895757e-02 1.722 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.910972e-02 1.719 0 0
Signaling by PTK6 R-HSA-8848021 1.910972e-02 1.719 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 1.977212e-02 1.704 0 0
CHL1 interactions R-HSA-447041 1.977212e-02 1.704 0 0
PTEN Regulation R-HSA-6807070 2.023679e-02 1.694 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 2.039539e-02 1.690 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 2.039539e-02 1.690 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 2.359405e-02 1.627 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 2.495814e-02 1.603 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 2.160844e-02 1.665 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 2.254496e-02 1.647 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 2.178320e-02 1.662 0 0
Protein folding R-HSA-391251 2.350844e-02 1.629 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 2.475296e-02 1.606 0 0
MTOR signalling R-HSA-165159 2.324310e-02 1.634 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 2.359405e-02 1.627 0 0
Assembly of the pre-replicative complex R-HSA-68867 2.449918e-02 1.611 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 2.495814e-02 1.603 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 2.359405e-02 1.627 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 2.179074e-02 1.662 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.495814e-02 1.603 0 0
Signaling by Interleukins R-HSA-449147 2.274775e-02 1.643 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 2.557110e-02 1.592 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 2.632073e-02 1.580 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 2.656356e-02 1.576 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 2.740859e-02 1.562 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 2.740859e-02 1.562 0 0
Eukaryotic Translation Termination R-HSA-72764 2.763774e-02 1.558 0 0
Lipophagy R-HSA-9613354 2.769201e-02 1.558 0 0
Unwinding of DNA R-HSA-176974 2.769201e-02 1.558 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 2.794680e-02 1.554 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.794680e-02 1.554 0 0
M Phase R-HSA-68886 2.840088e-02 1.547 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 2.848032e-02 1.545 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.874026e-02 1.542 0 0
MHC class II antigen presentation R-HSA-2132295 2.933389e-02 1.533 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 2.963150e-02 1.528 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 2.963150e-02 1.528 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 3.205270e-02 1.494 0 0
Degradation of CDH1 R-HSA-9766229 3.503995e-02 1.455 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 3.120634e-02 1.506 0 0
Cell-cell junction organization R-HSA-421270 3.324997e-02 1.478 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 3.596367e-02 1.444 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 3.458488e-02 1.461 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 3.575014e-02 1.447 0 0
Cell-Cell communication R-HSA-1500931 3.048763e-02 1.516 0 0
Intraflagellar transport R-HSA-5620924 3.317786e-02 1.479 0 0
Cellular response to starvation R-HSA-9711097 3.722903e-02 1.429 0 0
Death Receptor Signaling R-HSA-73887 3.325003e-02 1.478 0 0
Mitotic Anaphase R-HSA-68882 3.227097e-02 1.491 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 3.306115e-02 1.481 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 3.421630e-02 1.466 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 3.120634e-02 1.506 0 0
Selenocysteine synthesis R-HSA-2408557 3.468626e-02 1.460 0 0
Signaling by NOTCH4 R-HSA-9013694 3.262858e-02 1.486 0 0
Host Interactions of HIV factors R-HSA-162909 3.032996e-02 1.518 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 3.503995e-02 1.455 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 3.503995e-02 1.455 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 3.468626e-02 1.460 0 0
Viral mRNA Translation R-HSA-192823 3.727094e-02 1.429 0 0
Interferon gamma signaling R-HSA-877300 3.827169e-02 1.417 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 3.860825e-02 1.413 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 3.894267e-02 1.410 0 0
Hedgehog ligand biogenesis R-HSA-5358346 3.894267e-02 1.410 0 0
Regulation of TP53 Activity R-HSA-5633007 3.933377e-02 1.405 0 0
DARPP-32 events R-HSA-180024 4.001832e-02 1.398 0 0
Regulation of gene expression in beta cells R-HSA-210745 4.001832e-02 1.398 0 0
mRNA 3'-end processing R-HSA-72187 4.098345e-02 1.387 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 4.098345e-02 1.387 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 4.098345e-02 1.387 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 4.151120e-02 1.382 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 4.151120e-02 1.382 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 4.151120e-02 1.382 0 0
TICAM1 deficiency - HSE R-HSA-5602566 4.182765e-02 1.379 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 4.200584e-02 1.377 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 4.200584e-02 1.377 0 0
Activation of the pre-replicative complex R-HSA-68962 4.288735e-02 1.368 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 4.288735e-02 1.368 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 4.308387e-02 1.366 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 4.308387e-02 1.366 0 0
Smooth Muscle Contraction R-HSA-445355 4.308387e-02 1.366 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 4.426110e-02 1.354 0 0
CRMPs in Sema3A signaling R-HSA-399956 5.736120e-02 1.241 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 5.535407e-02 1.257 0 0
Striated Muscle Contraction R-HSA-390522 5.535407e-02 1.257 0 0
Translation initiation complex formation R-HSA-72649 4.524391e-02 1.344 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 4.974250e-02 1.303 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 4.545727e-02 1.342 0 0
Chaperonin-mediated protein folding R-HSA-390466 5.679999e-02 1.246 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 5.202000e-02 1.284 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 5.202000e-02 1.284 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 5.187162e-02 1.285 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 5.736120e-02 1.241 0 0
Cell junction organization R-HSA-446728 5.788146e-02 1.237 0 0
p75NTR recruits signalling complexes R-HSA-209543 4.658453e-02 1.332 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 4.746349e-02 1.324 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 4.974250e-02 1.303 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 4.585660e-02 1.339 0 0
eNOS activation R-HSA-203615 5.871219e-02 1.231 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 4.892496e-02 1.310 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 5.871219e-02 1.231 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 5.447815e-02 1.264 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 5.285399e-02 1.277 0 0
Integrin signaling R-HSA-354192 5.209121e-02 1.283 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.790383e-02 1.320 0 0
G0 and Early G1 R-HSA-1538133 4.892496e-02 1.310 0 0
Activation of ATR in response to replication stress R-HSA-176187 5.209121e-02 1.283 0 0
Vpu mediated degradation of CD4 R-HSA-180534 5.535407e-02 1.257 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 5.871219e-02 1.231 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 5.871219e-02 1.231 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 5.285399e-02 1.277 0 0
Gap junction assembly R-HSA-190861 5.871219e-02 1.231 0 0
Signaling by ERBB2 R-HSA-1227986 5.944919e-02 1.226 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 5.208078e-02 1.283 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 5.209121e-02 1.283 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 6.202230e-02 1.207 0 0
TRAF3 deficiency - HSE R-HSA-5602571 6.208261e-02 1.207 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 6.216411e-02 1.206 0 0
Regulation of Apoptosis R-HSA-169911 6.216411e-02 1.206 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 6.304241e-02 1.200 0 0
p75NTR signals via NF-kB R-HSA-193639 6.304241e-02 1.200 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 6.304241e-02 1.200 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 6.570834e-02 1.182 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 6.734201e-02 1.172 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 6.890476e-02 1.162 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 6.890476e-02 1.162 0 0
Negative regulation of FLT3 R-HSA-9706369 6.890476e-02 1.162 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 6.890476e-02 1.162 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 6.934331e-02 1.159 0 0
Degradation of DVL R-HSA-4641258 6.934331e-02 1.159 0 0
Degradation of AXIN R-HSA-4641257 6.934331e-02 1.159 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 6.934331e-02 1.159 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 6.934331e-02 1.159 0 0
Gastrulation R-HSA-9758941 6.959572e-02 1.157 0 0
Disease R-HSA-1643685 7.072780e-02 1.150 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 8.191062e-02 1.087 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 8.191062e-02 1.087 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 8.191062e-02 1.087 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 8.191062e-02 1.087 0 0
Defective ADA disrupts (deoxy)adenosine deamination R-HSA-9734735 8.191062e-02 1.087 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 8.191062e-02 1.087 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 8.191062e-02 1.087 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 8.191062e-02 1.087 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 8.191062e-02 1.087 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 8.191062e-02 1.087 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 8.191062e-02 1.087 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 8.191062e-02 1.087 0 0
Axonal growth stimulation R-HSA-209563 1.013206e-01 0.994 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 8.113264e-02 1.091 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 8.113264e-02 1.091 0 0
PKA activation R-HSA-163615 8.747889e-02 1.058 0 0
Regulation of signaling by CBL R-HSA-912631 9.396774e-02 1.027 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.073382e-01 0.969 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.073382e-01 0.969 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 7.493810e-02 1.125 0 0
Signaling by RAF1 mutants R-HSA-9656223 8.882087e-02 1.051 0 0
Proteasome assembly R-HSA-9907900 1.014856e-01 0.994 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 1.073382e-01 0.969 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 1.073382e-01 0.969 0 0
Regulation of cortical dendrite branching R-HSA-8985801 8.191062e-02 1.087 0 0
rRNA processing R-HSA-72312 9.434666e-02 1.025 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 7.306740e-02 1.136 0 0
DNA Replication R-HSA-69306 7.665564e-02 1.115 0 0
Degradation of CRY and PER proteins R-HSA-9932298 8.882087e-02 1.051 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 8.882087e-02 1.051 0 0
Cellular response to hypoxia R-HSA-1234174 7.289043e-02 1.137 0 0
Rap1 signalling R-HSA-392517 9.396774e-02 1.027 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 7.687895e-02 1.114 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.023900e-01 0.990 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 9.296462e-02 1.032 0 0
Nephrin family interactions R-HSA-373753 1.005904e-01 0.997 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.058591e-01 0.975 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.001361e-01 0.999 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 8.882087e-02 1.051 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 8.882087e-02 1.051 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 8.773746e-02 1.057 0 0
Innate Immune System R-HSA-168249 1.002025e-01 0.999 0 0
Adaptive Immune System R-HSA-1280218 7.715960e-02 1.113 0 0
ABC-family proteins mediated transport R-HSA-382556 9.160217e-02 1.038 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.026213e-01 0.989 0 0
Platelet degranulation R-HSA-114608 8.643157e-02 1.063 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 8.143604e-02 1.089 0 0
Signal Transduction R-HSA-162582 7.879726e-02 1.103 0 0
Gap junction trafficking R-HSA-190828 1.014856e-01 0.994 0 0
HIV Infection R-HSA-162906 8.604437e-02 1.065 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 7.687895e-02 1.114 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 1.058591e-01 0.975 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 1.025258e-01 0.989 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 7.493810e-02 1.125 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 8.077622e-02 1.093 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 8.475746e-02 1.072 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 1.058591e-01 0.975 0 0
Hedgehog 'on' state R-HSA-5632684 9.086985e-02 1.042 0 0
Hemostasis R-HSA-109582 9.840232e-02 1.007 0 0
Uptake and function of anthrax toxins R-HSA-5210891 8.113264e-02 1.091 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 8.747889e-02 1.058 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 1.058591e-01 0.975 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 1.058591e-01 0.975 0 0
Formation of definitive endoderm R-HSA-9823730 1.005904e-01 0.997 0 0
Signaling by Hippo R-HSA-2028269 8.113264e-02 1.091 0 0
Stabilization of p53 R-HSA-69541 7.687895e-02 1.114 0 0
Response to metal ions R-HSA-5660526 7.493810e-02 1.125 0 0
Interleukin-1 family signaling R-HSA-446652 7.485267e-02 1.126 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 1.080111e-01 0.967 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.103052e-01 0.957 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.103052e-01 0.957 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.103052e-01 0.957 0 0
Signaling by RAS mutants R-HSA-6802949 1.103052e-01 0.957 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.142032e-01 0.942 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.142032e-01 0.942 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.142032e-01 0.942 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.142032e-01 0.942 0 0
Attachment and Entry R-HSA-9694614 1.142032e-01 0.942 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.142032e-01 0.942 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.142409e-01 0.942 0 0
ABC transporter disorders R-HSA-5619084 1.142409e-01 0.942 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 1.148222e-01 0.940 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 1.148222e-01 0.940 0 0
Co-stimulation by CD28 R-HSA-389356 1.194079e-01 0.923 0 0
NGF-stimulated transcription R-HSA-9031628 1.194079e-01 0.923 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.196940e-01 0.922 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 1.203215e-01 0.920 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.203215e-01 0.920 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 1.203215e-01 0.920 0 0
NADE modulates death signalling R-HSA-205025 1.203215e-01 0.920 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 1.203215e-01 0.920 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 1.211772e-01 0.917 0 0
mTORC1-mediated signalling R-HSA-166208 1.211772e-01 0.917 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 1.389217e-01 0.857 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 1.389217e-01 0.857 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.389217e-01 0.857 0 0
G2 Phase R-HSA-68911 1.389217e-01 0.857 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 1.389217e-01 0.857 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 1.389217e-01 0.857 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 1.571298e-01 0.804 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 1.571298e-01 0.804 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 1.749539e-01 0.757 0 0
Autointegration results in viral DNA circles R-HSA-177539 1.749539e-01 0.757 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 1.749539e-01 0.757 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.924022e-01 0.716 0 0
IFNG signaling activates MAPKs R-HSA-9732724 1.924022e-01 0.716 0 0
TRIF-mediated programmed cell death R-HSA-2562578 1.924022e-01 0.716 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.924022e-01 0.716 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.924022e-01 0.716 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 2.094826e-01 0.679 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 2.094826e-01 0.679 0 0
CASP8 activity is inhibited R-HSA-5218900 2.262027e-01 0.646 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 2.425702e-01 0.615 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 2.425702e-01 0.615 0 0
Folding of actin by CCT/TriC R-HSA-390450 2.425702e-01 0.615 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 2.425702e-01 0.615 0 0
Long-term potentiation R-HSA-9620244 1.426789e-01 0.846 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.574259e-01 0.803 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 2.108515e-01 0.676 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 2.264527e-01 0.645 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.421329e-01 0.616 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.059636e-01 0.686 0 0
Signaling by EGFR in Cancer R-HSA-1643713 1.500157e-01 0.824 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 2.336879e-01 0.631 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.790776e-01 0.747 0 0
RAF activation R-HSA-5673000 2.186400e-01 0.660 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 1.571298e-01 0.804 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 2.262027e-01 0.646 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 2.094826e-01 0.679 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 2.425702e-01 0.615 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 1.724419e-01 0.763 0 0
CaM pathway R-HSA-111997 2.342851e-01 0.630 0 0
Calmodulin induced events R-HSA-111933 2.342851e-01 0.630 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 1.389217e-01 0.857 0 0
Activation of AKT2 R-HSA-165158 1.389217e-01 0.857 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 1.571298e-01 0.804 0 0
Calcineurin activates NFAT R-HSA-2025928 2.262027e-01 0.646 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.800356e-01 0.745 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 2.421329e-01 0.616 0 0
PLC beta mediated events R-HSA-112043 1.843765e-01 0.734 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 1.389217e-01 0.857 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.354223e-01 0.868 0 0
Neurodegenerative Diseases R-HSA-8863678 1.354223e-01 0.868 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 2.262027e-01 0.646 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.574259e-01 0.803 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 2.421329e-01 0.616 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 1.389217e-01 0.857 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 1.389217e-01 0.857 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 1.571298e-01 0.804 0 0
Threonine catabolism R-HSA-8849175 1.571298e-01 0.804 0 0
PDE3B signalling R-HSA-165160 1.571298e-01 0.804 0 0
Cam-PDE 1 activation R-HSA-111957 1.571298e-01 0.804 0 0
PKB-mediated events R-HSA-109703 1.571298e-01 0.804 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 1.924022e-01 0.716 0 0
Regulation by c-FLIP R-HSA-3371378 2.094826e-01 0.679 0 0
p75NTR regulates axonogenesis R-HSA-193697 2.262027e-01 0.646 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 1.649034e-01 0.783 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.724419e-01 0.763 0 0
Budding and maturation of HIV virion R-HSA-162588 1.876788e-01 0.727 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.972857e-01 0.705 0 0
G-protein mediated events R-HSA-112040 2.169656e-01 0.664 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.262027e-01 0.646 0 0
MyD88-independent TLR4 cascade R-HSA-166166 1.227043e-01 0.911 0 0
MAPK family signaling cascades R-HSA-5683057 1.661771e-01 0.779 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 1.227043e-01 0.911 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 1.924022e-01 0.716 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 2.094826e-01 0.679 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.953659e-01 0.709 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 2.303211e-01 0.638 0 0
Semaphorin interactions R-HSA-373755 1.950955e-01 0.710 0 0
Opioid Signalling R-HSA-111885 2.327919e-01 0.633 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 1.389217e-01 0.857 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.561539e-01 0.806 0 0
Translation R-HSA-72766 1.703052e-01 0.769 0 0
IRS activation R-HSA-74713 1.389217e-01 0.857 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 1.571298e-01 0.804 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 1.749539e-01 0.757 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 2.094826e-01 0.679 0 0
Dimerization of procaspase-8 R-HSA-69416 2.094826e-01 0.679 0 0
Nucleotide salvage defects R-HSA-9734207 2.094826e-01 0.679 0 0
ARMS-mediated activation R-HSA-170984 2.262027e-01 0.646 0 0
2-LTR circle formation R-HSA-164843 2.425702e-01 0.615 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 2.425702e-01 0.615 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 1.426789e-01 0.846 0 0
Pexophagy R-HSA-9664873 2.425702e-01 0.615 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 1.323875e-01 0.878 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 1.500157e-01 0.824 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.030919e-01 0.692 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 1.532671e-01 0.815 0 0
NRAGE signals death through JNK R-HSA-193648 1.583314e-01 0.800 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.225123e-01 0.653 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.347680e-01 0.629 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.350918e-01 0.869 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 1.389217e-01 0.857 0 0
VEGF ligand-receptor interactions R-HSA-194313 1.571298e-01 0.804 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 1.571298e-01 0.804 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 1.749539e-01 0.757 0 0
Regulation of PTEN localization R-HSA-8948747 1.924022e-01 0.716 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 2.262027e-01 0.646 0 0
MAPK3 (ERK1) activation R-HSA-110056 2.425702e-01 0.615 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 2.425702e-01 0.615 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 1.383990e-01 0.859 0 0
Regulation of necroptotic cell death R-HSA-5675482 2.030919e-01 0.692 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 1.240604e-01 0.906 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 2.232472e-01 0.651 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 1.571298e-01 0.804 0 0
HDL clearance R-HSA-8964011 1.749539e-01 0.757 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 1.924022e-01 0.716 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 2.262027e-01 0.646 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 2.262027e-01 0.646 0 0
Regulation of RAS by GAPs R-HSA-5658442 1.287778e-01 0.890 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.266532e-01 0.645 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 2.310457e-01 0.636 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.403984e-01 0.853 0 0
TCR signaling R-HSA-202403 1.227043e-01 0.911 0 0
Deubiquitination R-HSA-5688426 2.376410e-01 0.624 0 0
Josephin domain DUBs R-HSA-5689877 2.425702e-01 0.615 0 0
Regulation of the apoptosome activity R-HSA-9627069 2.425702e-01 0.615 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 2.030919e-01 0.692 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 1.482556e-01 0.829 0 0
Interleukin-27 signaling R-HSA-9020956 2.425702e-01 0.615 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 2.094826e-01 0.679 0 0
Signal attenuation R-HSA-74749 2.425702e-01 0.615 0 0
DNA strand elongation R-HSA-69190 1.953659e-01 0.709 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 1.319438e-01 0.880 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 1.414872e-01 0.849 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.447502e-01 0.839 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 1.924022e-01 0.716 0 0
Maturation of spike protein R-HSA-9683686 2.425702e-01 0.615 0 0
Downstream signal transduction R-HSA-186763 1.876788e-01 0.727 0 0
Gap junction trafficking and regulation R-HSA-157858 1.240604e-01 0.906 0 0
Rab regulation of trafficking R-HSA-9007101 1.513221e-01 0.820 0 0
RNA Polymerase II Transcription R-HSA-73857 1.527948e-01 0.816 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 1.843765e-01 0.734 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 2.094826e-01 0.679 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 2.425702e-01 0.615 0 0
Formation of apoptosome R-HSA-111458 2.425702e-01 0.615 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 1.335580e-01 0.874 0 0
Gene expression (Transcription) R-HSA-74160 2.048798e-01 0.689 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 1.583314e-01 0.800 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 2.186400e-01 0.660 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.016310e-01 0.695 0 0
Downstream TCR signaling R-HSA-202424 1.636590e-01 0.786 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.583314e-01 0.800 0 0
G1/S-Specific Transcription R-HSA-69205 2.342851e-01 0.630 0 0
Selenoamino acid metabolism R-HSA-2408522 1.966517e-01 0.706 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.016310e-01 0.695 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 1.389217e-01 0.857 0 0
Metabolism of polyamines R-HSA-351202 1.790776e-01 0.747 0 0
Metabolism of cofactors R-HSA-8978934 2.393134e-01 0.621 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 1.282527e-01 0.892 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 1.282527e-01 0.892 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 1.383990e-01 0.859 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.336879e-01 0.631 0 0
Regulation of beta-cell development R-HSA-186712 1.738217e-01 0.760 0 0
Signaling by WNT R-HSA-195721 2.428515e-01 0.615 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 2.449615e-01 0.611 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 2.499919e-01 0.602 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 2.499919e-01 0.602 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 2.499919e-01 0.602 0 0
Antigen processing-Cross presentation R-HSA-1236975 2.557245e-01 0.592 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 2.557245e-01 0.592 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 2.578582e-01 0.589 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 2.585924e-01 0.587 0 0
Ionotropic activity of kainate receptors R-HSA-451306 2.585924e-01 0.587 0 0
vRNP Assembly R-HSA-192905 2.585924e-01 0.587 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 2.585924e-01 0.587 0 0
Interleukin-2 signaling R-HSA-9020558 2.585924e-01 0.587 0 0
Neddylation R-HSA-8951664 2.588443e-01 0.587 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 2.603665e-01 0.584 0 0
Protein ubiquitination R-HSA-8852135 2.620256e-01 0.582 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 2.657280e-01 0.576 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 2.657280e-01 0.576 0 0
UCH proteinases R-HSA-5689603 2.677480e-01 0.572 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 2.735976e-01 0.563 0 0
Maturation of spike protein R-HSA-9694548 2.735976e-01 0.563 0 0
Activation of RAC1 R-HSA-428540 2.742767e-01 0.562 0 0
Integration of provirus R-HSA-162592 2.742767e-01 0.562 0 0
NF-kB is activated and signals survival R-HSA-209560 2.742767e-01 0.562 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 2.742767e-01 0.562 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 2.742767e-01 0.562 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 2.742767e-01 0.562 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 2.742767e-01 0.562 0 0
Sodium/Calcium exchangers R-HSA-425561 2.742767e-01 0.562 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 2.742767e-01 0.562 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 2.742767e-01 0.562 0 0
ER to Golgi Anterograde Transport R-HSA-199977 2.787807e-01 0.555 0 0
PCP/CE pathway R-HSA-4086400 2.792345e-01 0.554 0 0
MAP2K and MAPK activation R-HSA-5674135 2.814635e-01 0.551 0 0
Heme biosynthesis R-HSA-189451 2.814635e-01 0.551 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 2.828508e-01 0.548 0 0
Sensory processing of sound R-HSA-9659379 2.849954e-01 0.545 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 2.893224e-01 0.539 0 0
Ca-dependent events R-HSA-111996 2.893224e-01 0.539 0 0
Scavenging by Class F Receptors R-HSA-3000484 2.896302e-01 0.538 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.896302e-01 0.538 0 0
Regulation of IFNG signaling R-HSA-877312 2.896302e-01 0.538 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 2.896302e-01 0.538 0 0
Pervasive developmental disorders R-HSA-9005895 2.896302e-01 0.538 0 0
Disorders of Nervous System Development R-HSA-9697154 2.896302e-01 0.538 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.896302e-01 0.538 0 0
Interleukin-35 Signalling R-HSA-8984722 2.896302e-01 0.538 0 0
Toll-like Receptor Cascades R-HSA-168898 2.941206e-01 0.531 0 0
Signaling by SCF-KIT R-HSA-1433557 2.971711e-01 0.527 0 0
Interferon alpha/beta signaling R-HSA-909733 2.980171e-01 0.526 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 3.046597e-01 0.516 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 3.046597e-01 0.516 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 3.046597e-01 0.516 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 3.046597e-01 0.516 0 0
Frs2-mediated activation R-HSA-170968 3.046597e-01 0.516 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 3.046597e-01 0.516 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 3.046597e-01 0.516 0 0
Diseases of nucleotide metabolism R-HSA-9735804 3.046597e-01 0.516 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 3.046597e-01 0.516 0 0
Interleukin-6 signaling R-HSA-1059683 3.046597e-01 0.516 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 3.050065e-01 0.516 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 3.123144e-01 0.505 0 0
HCMV Early Events R-HSA-9609690 3.125455e-01 0.505 0 0
DAG and IP3 signaling R-HSA-1489509 3.128256e-01 0.505 0 0
Transmission across Chemical Synapses R-HSA-112315 3.134813e-01 0.504 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 3.139176e-01 0.503 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 3.139176e-01 0.503 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 3.193722e-01 0.496 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 3.193722e-01 0.496 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 3.193722e-01 0.496 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 3.193722e-01 0.496 0 0
NRIF signals cell death from the nucleus R-HSA-205043 3.193722e-01 0.496 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 3.193722e-01 0.496 0 0
Malate-aspartate shuttle R-HSA-9856872 3.193722e-01 0.496 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 3.193722e-01 0.496 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 3.193722e-01 0.496 0 0
Regulation of KIT signaling R-HSA-1433559 3.193722e-01 0.496 0 0
HDL assembly R-HSA-8963896 3.193722e-01 0.496 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 3.193944e-01 0.496 0 0
Oncogenic MAPK signaling R-HSA-6802957 3.197154e-01 0.495 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 3.206257e-01 0.494 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 3.240926e-01 0.489 0 0
Co-inhibition by PD-1 R-HSA-389948 3.274200e-01 0.485 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 3.284040e-01 0.484 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 3.284040e-01 0.484 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 3.337743e-01 0.477 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 3.337743e-01 0.477 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 3.337743e-01 0.477 0 0
Spry regulation of FGF signaling R-HSA-1295596 3.337743e-01 0.477 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 3.337743e-01 0.477 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 3.337743e-01 0.477 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 3.386381e-01 0.470 0 0
Diseases of programmed cell death R-HSA-9645723 3.429052e-01 0.465 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 3.478725e-01 0.459 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 3.478725e-01 0.459 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 3.478725e-01 0.459 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 3.478725e-01 0.459 0 0
Phosphorylation of the APC/C R-HSA-176412 3.478725e-01 0.459 0 0
Prolonged ERK activation events R-HSA-169893 3.478725e-01 0.459 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 3.478725e-01 0.459 0 0
Activation of SMO R-HSA-5635838 3.478725e-01 0.459 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 3.478725e-01 0.459 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 3.478725e-01 0.459 0 0
Attachment and Entry R-HSA-9678110 3.478725e-01 0.459 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 3.478725e-01 0.459 0 0
Virus Assembly and Release R-HSA-168268 3.478725e-01 0.459 0 0
ER-Phagosome pathway R-HSA-1236974 3.486959e-01 0.458 0 0
Neuronal System R-HSA-112316 3.539195e-01 0.451 0 0
HCMV Infection R-HSA-9609646 3.561494e-01 0.448 0 0
Generic Transcription Pathway R-HSA-212436 3.572526e-01 0.447 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 3.616732e-01 0.442 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 3.616732e-01 0.442 0 0
Disorders of Developmental Biology R-HSA-9675151 3.616732e-01 0.442 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 3.634008e-01 0.440 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 3.637989e-01 0.439 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 3.651047e-01 0.438 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 3.668841e-01 0.435 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 3.668841e-01 0.435 0 0
Signaling by Insulin receptor R-HSA-74752 3.717949e-01 0.430 0 0
Amino acids regulate mTORC1 R-HSA-9639288 3.744822e-01 0.427 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 3.744822e-01 0.427 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 3.744822e-01 0.427 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 3.751826e-01 0.426 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 3.751826e-01 0.426 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 3.751826e-01 0.426 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 3.884070e-01 0.411 0 0
Ephrin signaling R-HSA-3928664 3.884070e-01 0.411 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 3.884070e-01 0.411 0 0
PKA activation in glucagon signalling R-HSA-164378 3.884070e-01 0.411 0 0
Presynaptic function of Kainate receptors R-HSA-500657 3.884070e-01 0.411 0 0
Apoptotic factor-mediated response R-HSA-111471 3.884070e-01 0.411 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 3.884070e-01 0.411 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 3.884070e-01 0.411 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 3.884070e-01 0.411 0 0
Polo-like kinase mediated events R-HSA-156711 3.884070e-01 0.411 1 1
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 3.890203e-01 0.410 0 0
Circadian clock R-HSA-9909396 3.890980e-01 0.410 0 0
Ub-specific processing proteases R-HSA-5689880 3.911201e-01 0.408 0 0
Signaling by EGFR R-HSA-177929 3.970455e-01 0.401 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 3.970455e-01 0.401 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 4.013523e-01 0.396 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 4.013523e-01 0.396 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 4.013523e-01 0.396 0 0
Translesion Synthesis by POLH R-HSA-110320 4.013523e-01 0.396 0 0
E2F mediated regulation of DNA replication R-HSA-113510 4.013523e-01 0.396 0 0
The NLRP3 inflammasome R-HSA-844456 4.013523e-01 0.396 0 0
Dectin-2 family R-HSA-5621480 4.044838e-01 0.393 0 0
Nuclear Envelope Breakdown R-HSA-2980766 4.044838e-01 0.393 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 4.118015e-01 0.385 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 4.118015e-01 0.385 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 4.118015e-01 0.385 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 4.118781e-01 0.385 0 0
Negative regulation of MET activity R-HSA-6807004 4.140243e-01 0.383 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 4.140243e-01 0.383 0 0
Protein hydroxylation R-HSA-9629569 4.140243e-01 0.383 0 0
Signal transduction by L1 R-HSA-445144 4.140243e-01 0.383 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 4.177193e-01 0.379 0 0
Glycolysis R-HSA-70171 4.230949e-01 0.374 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 4.264289e-01 0.370 0 0
Early Phase of HIV Life Cycle R-HSA-162594 4.264289e-01 0.370 0 0
Basigin interactions R-HSA-210991 4.264289e-01 0.370 0 0
MAP kinase activation R-HSA-450294 4.337823e-01 0.363 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 4.366341e-01 0.360 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 4.385716e-01 0.358 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 4.385716e-01 0.358 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 4.385716e-01 0.358 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 4.385716e-01 0.358 0 0
Assembly Of The HIV Virion R-HSA-175474 4.385716e-01 0.358 0 0
Serine metabolism R-HSA-977347 4.385716e-01 0.358 0 0
Mitochondrial calcium ion transport R-HSA-8949215 4.385716e-01 0.358 0 0
Signaling by PDGFR in disease R-HSA-9671555 4.385716e-01 0.358 0 0
Ribavirin ADME R-HSA-9755088 4.385716e-01 0.358 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 4.409866e-01 0.356 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 4.409866e-01 0.356 0 0
Signaling by PDGF R-HSA-186797 4.409866e-01 0.356 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 4.454519e-01 0.351 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 4.504580e-01 0.346 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 4.504580e-01 0.346 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 4.504580e-01 0.346 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 4.504580e-01 0.346 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 4.504580e-01 0.346 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 4.504580e-01 0.346 0 0
Clathrin-mediated endocytosis R-HSA-8856828 4.507068e-01 0.346 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 4.552423e-01 0.342 0 0
Insulin receptor signalling cascade R-HSA-74751 4.552423e-01 0.342 0 0
Nucleotide Excision Repair R-HSA-5696398 4.565025e-01 0.341 0 0
Termination of O-glycan biosynthesis R-HSA-977068 4.620934e-01 0.335 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 4.620934e-01 0.335 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 4.692873e-01 0.329 0 0
ESR-mediated signaling R-HSA-8939211 4.700691e-01 0.328 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 4.729019e-01 0.325 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 4.734832e-01 0.325 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 4.734832e-01 0.325 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 4.734832e-01 0.325 0 0
Complex III assembly R-HSA-9865881 4.734832e-01 0.325 0 0
Mitochondrial RNA degradation R-HSA-9836573 4.734832e-01 0.325 0 0
Plasma lipoprotein assembly R-HSA-8963898 4.734832e-01 0.325 0 0
Interleukin-6 family signaling R-HSA-6783589 4.734832e-01 0.325 0 0
Signaling by NTRKs R-HSA-166520 4.739030e-01 0.324 0 0
Signaling by NOTCH R-HSA-157118 4.811239e-01 0.318 0 0
Potential therapeutics for SARS R-HSA-9679191 4.830797e-01 0.316 0 0
Regulated Necrosis R-HSA-5218859 4.831144e-01 0.316 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 4.846325e-01 0.315 0 0
Interleukin-7 signaling R-HSA-1266695 4.846325e-01 0.315 0 0
HDMs demethylate histones R-HSA-3214842 4.846325e-01 0.315 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 4.846325e-01 0.315 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 4.846325e-01 0.315 0 0
RAF/MAP kinase cascade R-HSA-5673001 4.902265e-01 0.310 0 0
Inositol phosphate metabolism R-HSA-1483249 4.944102e-01 0.306 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 4.955464e-01 0.305 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 4.955464e-01 0.305 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 4.955464e-01 0.305 0 0
Interleukin-17 signaling R-HSA-448424 4.967172e-01 0.304 0 0
Metabolism of porphyrins R-HSA-189445 5.034327e-01 0.298 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 5.062298e-01 0.296 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 5.062298e-01 0.296 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 5.062298e-01 0.296 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 5.100901e-01 0.292 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 5.100901e-01 0.292 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 5.102071e-01 0.292 0 0
HIV Life Cycle R-HSA-162587 5.146751e-01 0.288 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 5.166877e-01 0.287 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 5.166877e-01 0.287 0 0
Insulin receptor recycling R-HSA-77387 5.166877e-01 0.287 0 0
Telomere Extension By Telomerase R-HSA-171319 5.166877e-01 0.287 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 5.166877e-01 0.287 0 0
Inflammasomes R-HSA-622312 5.166877e-01 0.287 0 0
Ca2+ pathway R-HSA-4086398 5.166889e-01 0.287 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 5.232286e-01 0.281 0 0
ROS and RNS production in phagocytes R-HSA-1222556 5.232286e-01 0.281 0 0
Signaling by ERBB4 R-HSA-1236394 5.232286e-01 0.281 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 5.269246e-01 0.278 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 5.269246e-01 0.278 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 5.269246e-01 0.278 0 0
Platelet calcium homeostasis R-HSA-418360 5.269246e-01 0.278 0 0
Signaling by TGFB family members R-HSA-9006936 5.279431e-01 0.277 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 5.297088e-01 0.276 0 0
Iron uptake and transport R-HSA-917937 5.297088e-01 0.276 0 0
Glucose metabolism R-HSA-70326 5.309629e-01 0.275 0 0
Homology Directed Repair R-HSA-5693538 5.360638e-01 0.271 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 5.369453e-01 0.270 0 0
DAP12 signaling R-HSA-2424491 5.369453e-01 0.270 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 5.369453e-01 0.270 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 5.369453e-01 0.270 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 5.369453e-01 0.270 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 5.369453e-01 0.270 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 5.411332e-01 0.267 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 5.411332e-01 0.267 0 0
Translation of Structural Proteins R-HSA-9694635 5.424887e-01 0.266 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 5.467544e-01 0.262 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 5.467544e-01 0.262 0 0
EGFR downregulation R-HSA-182971 5.467544e-01 0.262 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 5.467544e-01 0.262 0 0
Aspartate and asparagine metabolism R-HSA-8963693 5.467544e-01 0.262 0 0
G alpha (12/13) signalling events R-HSA-416482 5.487878e-01 0.261 0 0
Integrin cell surface interactions R-HSA-216083 5.487878e-01 0.261 0 0
Muscle contraction R-HSA-397014 5.529980e-01 0.257 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 5.561484e-01 0.255 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 5.561484e-01 0.255 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 5.563563e-01 0.255 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 5.657554e-01 0.247 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 5.657554e-01 0.247 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 5.657554e-01 0.247 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 5.657554e-01 0.247 0 0
Processing of DNA double-strand break ends R-HSA-5693607 5.673185e-01 0.246 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 5.733725e-01 0.242 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 5.749558e-01 0.240 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 5.749558e-01 0.240 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 5.749558e-01 0.240 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 5.749558e-01 0.240 0 0
Glutamate and glutamine metabolism R-HSA-8964539 5.749558e-01 0.240 0 0
Miscellaneous transport and binding events R-HSA-5223345 5.749558e-01 0.240 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 5.805108e-01 0.236 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 5.839620e-01 0.234 0 0
NOD1/2 Signaling Pathway R-HSA-168638 5.839620e-01 0.234 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 5.839620e-01 0.234 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 5.839620e-01 0.234 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 5.839620e-01 0.234 0 0
Nuclear import of Rev protein R-HSA-180746 5.839620e-01 0.234 0 0
Calnexin/calreticulin cycle R-HSA-901042 5.839620e-01 0.234 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 5.839620e-01 0.234 0 0
Mitophagy R-HSA-5205647 5.839620e-01 0.234 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 5.839620e-01 0.234 0 0
Meiosis R-HSA-1500620 5.911637e-01 0.228 0 0
Protein-protein interactions at synapses R-HSA-6794362 5.911637e-01 0.228 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 5.914570e-01 0.228 0 0
Signalling to ERKs R-HSA-187687 5.927778e-01 0.227 0 0
Transferrin endocytosis and recycling R-HSA-917977 5.927778e-01 0.227 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 5.927778e-01 0.227 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 5.969704e-01 0.224 0 0
Amplification of signal from the kinetochores R-HSA-141424 5.969704e-01 0.224 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 5.993840e-01 0.222 0 0
GPVI-mediated activation cascade R-HSA-114604 6.014073e-01 0.221 0 0
RNA Polymerase III Transcription R-HSA-74158 6.014073e-01 0.221 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 6.014073e-01 0.221 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 6.014073e-01 0.221 0 0
Triglyceride catabolism R-HSA-163560 6.014073e-01 0.221 0 0
RET signaling R-HSA-8853659 6.014073e-01 0.221 0 0
FLT3 signaling in disease R-HSA-9682385 6.014073e-01 0.221 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 6.027151e-01 0.220 0 0
XBP1(S) activates chaperone genes R-HSA-381038 6.027151e-01 0.220 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 6.046887e-01 0.218 0 0
Pyruvate metabolism R-HSA-70268 6.083978e-01 0.216 0 0
Voltage gated Potassium channels R-HSA-1296072 6.098545e-01 0.215 0 0
Cellular Senescence R-HSA-2559583 6.154151e-01 0.211 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 6.181232e-01 0.209 0 0
Purine salvage R-HSA-74217 6.181232e-01 0.209 0 0
Leishmania infection R-HSA-9658195 6.227125e-01 0.206 0 0
Parasitic Infection Pathways R-HSA-9824443 6.227125e-01 0.206 0 0
Neurotransmitter release cycle R-HSA-112310 6.250752e-01 0.204 0 0
Base Excision Repair R-HSA-73884 6.250752e-01 0.204 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 6.262172e-01 0.203 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 6.262172e-01 0.203 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 6.262172e-01 0.203 0 0
RAS processing R-HSA-9648002 6.262172e-01 0.203 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 6.262172e-01 0.203 0 0
Pentose phosphate pathway R-HSA-71336 6.262172e-01 0.203 0 0
Plasma lipoprotein clearance R-HSA-8964043 6.262172e-01 0.203 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 6.341400e-01 0.198 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 6.341400e-01 0.198 0 0
Generation of second messenger molecules R-HSA-202433 6.341400e-01 0.198 0 0
Diseases of Immune System R-HSA-5260271 6.341400e-01 0.198 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 6.341400e-01 0.198 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 6.341400e-01 0.198 0 0
Glycogen metabolism R-HSA-8982491 6.341400e-01 0.198 0 0
Interleukin-2 family signaling R-HSA-451927 6.341400e-01 0.198 0 0
IRE1alpha activates chaperones R-HSA-381070 6.358852e-01 0.197 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 6.411982e-01 0.193 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 6.411982e-01 0.193 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 6.418955e-01 0.193 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 6.418955e-01 0.193 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 6.418955e-01 0.193 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 6.418955e-01 0.193 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 6.464501e-01 0.189 0 0
Intra-Golgi traffic R-HSA-6811438 6.494869e-01 0.187 0 0
Negative regulation of MAPK pathway R-HSA-5675221 6.494869e-01 0.187 0 0
Translation of Structural Proteins R-HSA-9683701 6.494869e-01 0.187 0 0
Parasite infection R-HSA-9664407 6.525887e-01 0.185 0 0
Leishmania phagocytosis R-HSA-9664417 6.525887e-01 0.185 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 6.525887e-01 0.185 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 6.569180e-01 0.182 0 0
Depyrimidination R-HSA-73928 6.569180e-01 0.182 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 6.569180e-01 0.182 0 0
Signaling by FGFR4 R-HSA-5654743 6.641919e-01 0.178 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 6.641919e-01 0.178 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 6.650743e-01 0.177 0 0
Late Phase of HIV Life Cycle R-HSA-162599 6.650743e-01 0.177 0 0
DAP12 interactions R-HSA-2172127 6.713120e-01 0.173 0 0
Netrin-1 signaling R-HSA-373752 6.713120e-01 0.173 0 0
G1 Phase R-HSA-69236 6.713120e-01 0.173 0 0
Cyclin D associated events in G1 R-HSA-69231 6.713120e-01 0.173 0 0
FCERI mediated NF-kB activation R-HSA-2871837 6.732156e-01 0.172 0 0
Disorders of transmembrane transporters R-HSA-5619115 6.754363e-01 0.170 0 0
Regulation of insulin secretion R-HSA-422356 6.766906e-01 0.170 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 6.782816e-01 0.169 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 6.782816e-01 0.169 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 6.782816e-01 0.169 0 0
Signaling by FGFR3 R-HSA-5654741 6.782816e-01 0.169 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 6.782816e-01 0.169 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 6.851039e-01 0.164 0 0
Regulation of TNFR1 signaling R-HSA-5357905 6.851039e-01 0.164 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 6.851039e-01 0.164 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 6.851039e-01 0.164 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 6.851039e-01 0.164 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 6.851039e-01 0.164 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 6.851039e-01 0.164 0 0
Regulation of pyruvate metabolism R-HSA-9861718 6.851039e-01 0.164 0 0
Apoptotic execution phase R-HSA-75153 6.851039e-01 0.164 0 0
Mitotic Spindle Checkpoint R-HSA-69618 6.862931e-01 0.163 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 6.983186e-01 0.156 0 0
GPER1 signaling R-HSA-9634597 6.983186e-01 0.156 0 0
Metal ion SLC transporters R-HSA-425410 6.983186e-01 0.156 0 0
DNA Repair R-HSA-73894 7.037931e-01 0.153 0 0
DNA Damage Bypass R-HSA-73893 7.047171e-01 0.152 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 7.047171e-01 0.152 0 0
DNA Double-Strand Break Repair R-HSA-5693532 7.080492e-01 0.150 0 0
PI3K Cascade R-HSA-109704 7.109803e-01 0.148 0 0
Metabolism of amino acids and derivatives R-HSA-71291 7.142643e-01 0.146 0 0
The phototransduction cascade R-HSA-2514856 7.171111e-01 0.144 0 0
Meiotic recombination R-HSA-912446 7.171111e-01 0.144 0 0
Gene Silencing by RNA R-HSA-211000 7.223839e-01 0.141 0 0
Neurexins and neuroligins R-HSA-6794361 7.231121e-01 0.141 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 7.289862e-01 0.137 0 0
Meiotic synapsis R-HSA-1221632 7.289862e-01 0.137 0 0
Asparagine N-linked glycosylation R-HSA-446203 7.311409e-01 0.136 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 7.347361e-01 0.134 0 0
Paracetamol ADME R-HSA-9753281 7.403643e-01 0.131 0 0
Signaling by NOTCH3 R-HSA-9012852 7.403643e-01 0.131 0 0
FCERI mediated MAPK activation R-HSA-2871796 7.431191e-01 0.129 0 0
TNF signaling R-HSA-75893 7.458734e-01 0.127 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 7.458734e-01 0.127 0 0
Ion homeostasis R-HSA-5578775 7.458734e-01 0.127 0 0
Signaling by FGFR1 R-HSA-5654736 7.458734e-01 0.127 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 7.510355e-01 0.124 0 0
IRS-mediated signalling R-HSA-112399 7.512660e-01 0.124 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 7.565445e-01 0.121 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 7.617112e-01 0.118 0 0
snRNP Assembly R-HSA-191859 7.617112e-01 0.118 0 0
Metabolism of non-coding RNA R-HSA-194441 7.617112e-01 0.118 0 0
Extension of Telomeres R-HSA-180786 7.617112e-01 0.118 0 0
Triglyceride metabolism R-HSA-8979227 7.617112e-01 0.118 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 7.625169e-01 0.118 0 0
Regulation of PTEN gene transcription R-HSA-8943724 7.667686e-01 0.115 0 0
Glutathione conjugation R-HSA-156590 7.667686e-01 0.115 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 7.667686e-01 0.115 0 0
tRNA processing R-HSA-72306 7.690689e-01 0.114 0 0
Viral Messenger RNA Synthesis R-HSA-168325 7.717190e-01 0.113 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 7.717190e-01 0.113 0 0
Aquaporin-mediated transport R-HSA-445717 7.717190e-01 0.113 0 0
Nucleotide salvage R-HSA-8956321 7.717190e-01 0.113 0 0
Collagen degradation R-HSA-1442490 7.717190e-01 0.113 0 0
Bacterial Infection Pathways R-HSA-9824439 7.759497e-01 0.110 0 0
Mitochondrial protein import R-HSA-1268020 7.765647e-01 0.110 0 0
tRNA processing in the nucleus R-HSA-6784531 7.765647e-01 0.110 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 7.765647e-01 0.110 0 0
Leishmania parasite growth and survival R-HSA-9664433 7.781604e-01 0.109 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 7.781604e-01 0.109 0 0
Mitotic Prophase R-HSA-68875 7.806345e-01 0.108 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 7.813077e-01 0.107 0 0
IGF1R signaling cascade R-HSA-2428924 7.859504e-01 0.105 0 0
Ion transport by P-type ATPases R-HSA-936837 7.859504e-01 0.105 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 7.904947e-01 0.102 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 7.949429e-01 0.100 0 0
DNA Double Strand Break Response R-HSA-5693606 7.992969e-01 0.097 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 8.007698e-01 0.096 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 8.007698e-01 0.096 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 8.007698e-01 0.096 0 0
O-linked glycosylation of mucins R-HSA-913709 8.035587e-01 0.095 0 0
COPII-mediated vesicle transport R-HSA-204005 8.118135e-01 0.091 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 8.118135e-01 0.091 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 8.158103e-01 0.088 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 8.158103e-01 0.088 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 8.158103e-01 0.088 0 0
Reproduction R-HSA-1474165 8.192520e-01 0.087 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 8.197224e-01 0.086 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 8.197224e-01 0.086 0 0
Degradation of the extracellular matrix R-HSA-1474228 8.250635e-01 0.084 0 0
Signaling by Nuclear Receptors R-HSA-9006931 8.281211e-01 0.082 0 0
Post-translational protein modification R-HSA-597592 8.286508e-01 0.082 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 8.309686e-01 0.080 0 0
ISG15 antiviral mechanism R-HSA-1169408 8.309686e-01 0.080 0 0
Integration of energy metabolism R-HSA-163685 8.388653e-01 0.076 0 0
Unfolded Protein Response (UPR) R-HSA-381119 8.466668e-01 0.072 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 8.481791e-01 0.072 0 0
Signaling by FGFR2 R-HSA-5654738 8.481791e-01 0.072 0 0
Signaling by MET R-HSA-6806834 8.481791e-01 0.072 0 0
Amyloid fiber formation R-HSA-977225 8.514055e-01 0.070 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 8.514055e-01 0.070 0 0
Infection with Enterobacteria R-HSA-9640148 8.537746e-01 0.069 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 8.693777e-01 0.061 0 0
Sulfur amino acid metabolism R-HSA-1614635 8.693777e-01 0.061 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 8.693777e-01 0.061 0 0
Interleukin-12 family signaling R-HSA-447115 8.721548e-01 0.059 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 8.826869e-01 0.054 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 8.827645e-01 0.054 0 0
HCMV Late Events R-HSA-9610379 8.885923e-01 0.051 0 0
FCGR activation R-HSA-2029481 8.900140e-01 0.051 0 0
Mitochondrial protein degradation R-HSA-9837999 8.923536e-01 0.049 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 8.990786e-01 0.046 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 8.990786e-01 0.046 0 0
Potassium Channels R-HSA-1296071 8.990786e-01 0.046 0 0
Metabolism of proteins R-HSA-392499 8.995383e-01 0.046 0 0
Telomere Maintenance R-HSA-157579 9.012258e-01 0.045 0 0
Signaling by FGFR R-HSA-190236 9.033275e-01 0.044 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.053846e-01 0.043 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 9.112977e-01 0.040 0 0
PI Metabolism R-HSA-1483255 9.112977e-01 0.040 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.127490e-01 0.040 0 0
RSV-host interactions R-HSA-9833110 9.168423e-01 0.038 0 0
Activation of HOX genes during differentiation R-HSA-5619507 9.168423e-01 0.038 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 9.168423e-01 0.038 0 0
Platelet homeostasis R-HSA-418346 9.203453e-01 0.036 0 0
Stimuli-sensing channels R-HSA-2672351 9.237011e-01 0.034 0 0
Respiratory electron transport R-HSA-611105 9.237799e-01 0.034 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.269160e-01 0.033 0 0
Epigenetic regulation of gene expression R-HSA-212165 9.357696e-01 0.029 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.371408e-01 0.028 0 0
Ion channel transport R-HSA-983712 9.371695e-01 0.028 0 0
Mitochondrial biogenesis R-HSA-1592230 9.397908e-01 0.027 0 0
Developmental Cell Lineages R-HSA-9734767 9.415729e-01 0.026 0 0
Chromosome Maintenance R-HSA-73886 9.447613e-01 0.025 0 0
Transport of small molecules R-HSA-382551 9.447962e-01 0.025 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.470909e-01 0.024 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.470909e-01 0.024 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 9.470909e-01 0.024 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.503933e-01 0.022 0 0
Adipogenesis R-HSA-9843745 9.573490e-01 0.019 0 0
Cardiac conduction R-HSA-5576891 9.573490e-01 0.019 0 0
Sensory perception of taste R-HSA-9717189 9.573490e-01 0.019 0 0
Estrogen-dependent gene expression R-HSA-9018519 9.625252e-01 0.017 0 0
Drug ADME R-HSA-9748784 9.632660e-01 0.016 0 0
O-linked glycosylation R-HSA-5173105 9.633248e-01 0.016 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.699255e-01 0.013 0 0
Visual phototransduction R-HSA-2187338 9.710733e-01 0.013 0 0
Chromatin modifying enzymes R-HSA-3247509 9.725534e-01 0.012 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.728872e-01 0.012 0 0
Metabolism of nucleotides R-HSA-15869 9.735415e-01 0.012 0 0
Protein localization R-HSA-9609507 9.745876e-01 0.011 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.753253e-01 0.011 0 0
PPARA activates gene expression R-HSA-1989781 9.756617e-01 0.011 0 0
GPCR downstream signalling R-HSA-388396 9.763006e-01 0.010 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.766905e-01 0.010 0 0
Chromatin organization R-HSA-4839726 9.791761e-01 0.009 0 0
Extracellular matrix organization R-HSA-1474244 9.806423e-01 0.008 0 0
SLC transporter disorders R-HSA-5619102 9.812195e-01 0.008 0 0
G alpha (i) signalling events R-HSA-418594 9.819222e-01 0.008 0 0
G alpha (s) signalling events R-HSA-418555 9.831433e-01 0.007 0 0
G alpha (q) signalling events R-HSA-416476 9.842412e-01 0.007 0 0
Diseases of glycosylation R-HSA-3781865 9.872745e-01 0.006 0 0
Peptide ligand-binding receptors R-HSA-375276 9.878135e-01 0.005 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.889420e-01 0.005 0 0
Sphingolipid metabolism R-HSA-428157 9.911924e-01 0.004 0 0
Signaling by GPCR R-HSA-372790 9.913065e-01 0.004 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.938723e-01 0.003 0 0
Phase II - Conjugation of compounds R-HSA-156580 9.962194e-01 0.002 0 0
Phospholipid metabolism R-HSA-1483257 9.988816e-01 0.000 0 0
Diseases of metabolism R-HSA-5668914 9.993394e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.994058e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.998743e-01 0.000 0 0
Biological oxidations R-HSA-211859 9.999927e-01 0.000 0 0
GPCR ligand binding R-HSA-500792 9.999983e-01 0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways