PDHK3

TYR version of PSPA with Y as phospho-acceptor
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
Y Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: Y Sites / Y Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
A2RRP1 S473 Sugiyama NBAS NAG APKRSRLETRAGEEDEGEEDsDsDyEISAKARYFGYIKQGL
A5A3E0 Y940 Sugiyama POTEF A26C1B ALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPEA
O43852 Y47 Sugiyama CALU RVHHEPQLsDKVHNDAQsFDyDHDAFLGAEEAKtFDQLtPE
P00533 Y764 Sugiyama EGFR ERBB ERBB1 HER1 IKELREATSPKANKEILDEAyVMAsVDNPHVCRLLGICLTS
P00558 Y161 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 KAEPAKIEAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNL
P04075 S336 Sugiyama ALDOA ALDA GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04406 Y314 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 tFDAGAGIALNDHFVKLIsWyDNEFGysNRVVDLMAHMAsK
P04406 Y320 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 GIALNDHFVKLIsWyDNEFGysNRVVDLMAHMAsKE_____
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P06733 Y44 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 LFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKGVSK
P07205 Y161 Sugiyama PGK2 PGKB KAEPDKIEAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNL
P07437 Y50 Sugiyama TUBB TUBB5 OK/SW-cl.56 IDPTGtyHGDsDLQLDRIsVyyNEAtGGKyVPRAILVDLEP
P07900 Y309 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA ELNKtKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHF
P07900 Y313 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA tKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEG
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 Y301 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB ELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHF
P08238 Y305 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB tKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEG
P08559 S232 SIGNOR|iPTMNet PDHA1 PHE1A ALWKLPCIFICENNRYGMGtsVERAAAsTDYYKRGDFIPGL
P08559 S293 GPS6|SIGNOR|ELM|iPTMNet|PSP PDHA1 PHE1A CRSGKGPILMELQTYRyHGHsMsDPGVsyRtREEIQEVRsK
P08559 S300 GPS6|SIGNOR|ELM|PSP PDHA1 PHE1A ILMELQTYRyHGHsMsDPGVsyRtREEIQEVRsKsDPIMLL
P08865 Y156 Sugiyama RPSA LAMBR LAMR1 EAsyVNLPtIALCNTDSPLRyVDIAIPCNNKGAHSVGLMWW
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P12277 S164 Sugiyama CKB CKBB PHCsRGERRAIEKLAVEALssLDGDLAGRyyALKsMtEAEQ
P12277 Y39 Sugiyama CKB CKBB EFPDLSAHNNHMAKVLtPELyAELRAKSTPSGFTLDDVIQT
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P23193 Y177 Sugiyama TCEA1 GTF2S TFIIS DYIAIGADEEELGSQIEEAIyQEIRNTDMKYKNRVRSRISN
P23588 Y609 Sugiyama EIF4B sASKyAALsVDGEDENEGEDyAE__________________
P29803 S291 SIGNOR|PSP PDHA2 PDHAL CRSGKGPILMELQTYRyHGHsMsDPGVsyRtREEIQEVRsK
P29803 S298 PSP PDHA2 PDHAL ILMELQTYRyHGHsMsDPGVsyRtREEIQEVRsKRDPIIIL
P31946 S60 GPS6 YWHAB NEERNLLsVAyKNVVGARRSsWRVIsSIEQKTERNEKKQQM
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P39019 Y48 Sugiyama RPS19 LKVPEWVDtVKLAKHKELAPyDENWFytRAAstARHLYLRG
P39019 Y54 Sugiyama RPS19 VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P50454 S139 Sugiyama SERPINH1 CBP1 CBP2 HSP47 SERPINH2 PIG14 SNSTARNVTWKLGsRLyGPssVsFADDFVRssKQHYNCEHS
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P60660 Y89 Sugiyama MYL6 HFLPMLQTVAKNKDQGtyEDyVEGLRVFDKEGNGtVMGAEI
P60709 Y240 Sugiyama ACTB ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62736 Y242 Sugiyama ACTA2 ACTSA ACTVS GIG46 ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P62750 Y144 Sugiyama RPL23A VNtLIRPDGEKKAYVRLAPDyDALDVANKIGII________
P63261 Y240 Sugiyama ACTG1 ACTG ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P63267 Y241 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P67809 S209 Sugiyama YBX1 NSEP1 YB1 RRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGEQ
P68032 Y242 Sugiyama ACTC1 ACTC ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68133 Y242 Sugiyama ACTA1 ACTA ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68363 Y432 Sugiyama TUBA1B GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q01105 Y146 Sugiyama SET tEFEDIKsGyRIDFyFDENPyFENKVLSKEFHLNEsGDPss
Q04917 S59 GPS6 YWHAH YWHA1 NEDRNLLsVAyKNVVGARRSsWRVIsSIEQKTMADGNEKKL
Q06830 Y116 Sugiyama PRDX1 PAGA PAGB TDPX2 GLGPMNIPLVSDPKRtIAQDyGVLKADEGIsFRGLFIIDDK
Q14247 Y334 Sugiyama CTTN EMS1 KDRMDKNAstFEDVtQVssAyQKTVPVEAVtsKtsNIRANF
Q14677 S166 Sugiyama CLINT1 ENTH EPN4 EPNR KIAA0171 REERKKAKKNKDKyVGVssDsVGGFRysERYDPEPKSKWDE
Q15120 S25 Sugiyama PDK3 PDHK3 RWLLKQPVPKQIERYSRFsPsPLSIKQFLDFGRDNACEKTS
Q15120 S390 Sugiyama PDK3 PDHK3 PVFNKSAWRHYKttPEADDWsNPssEPRDASKYKAKQ____
Q15120 S393 Sugiyama PDK3 PDHK3 NKSAWRHYKttPEADDWsNPssEPRDASKYKAKQ_______
Q15120 S394 Sugiyama PDK3 PDHK3 KSAWRHYKttPEADDWsNPssEPRDASKYKAKQ________
Q15120 T382 Sugiyama PDK3 PDHK3 SSESFERLPVFNKSAWRHYKttPEADDWsNPssEPRDASKY
Q15120 T383 Sugiyama PDK3 PDHK3 SESFERLPVFNKSAWRHYKttPEADDWsNPssEPRDASKYK
Q15293 Y278 Sugiyama RCN1 RCN LNKDGKLDKDEIRHWILPQDyDHAQAEARHLVyESDKNKDE
Q562R1 Y241 Sugiyama ACTBL2 ALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPEA
Q6S8J3 Y940 Sugiyama POTEE A26C1A POTE2 ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
Q71U36 Y432 Sugiyama TUBA1A TUBA3 GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q86V81 Y250 Sugiyama ALYREF ALY BEF THOC4 AGRNSKQQLsAEELDAQLDAyNARMDts_____________
Q99613 S865 Sugiyama EIF3C EIF3S8 HRTEPTAQQNLALQLAEKLGsLVENNERVFDHKQGtyGGyF
Q9BYX7 Y240 Sugiyama POTEKP ACTBL3 FKSG30 ALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPEA
Q9NYF8 Y383 Sugiyama BCLAF1 BTF KIAA0164 EKGSEKGRAEGEWEDQEALDyFsDKEsGKQKFNDsEGDDtE
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Interferon alpha/beta signaling R-HSA-909733 0.001566 2.805 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 0.002730 2.564 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 0.003434 2.464 0 0
Neutrophil degranulation R-HSA-6798695 0.006245 2.204 0 0
Unwinding of DNA R-HSA-176974 0.005993 2.222 0 0
DNA strand elongation R-HSA-69190 0.005911 2.228 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 0.005067 2.295 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 0.005067 2.295 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 0.008156 2.089 0 0
Formation of the posterior neural plate R-HSA-9832991 0.008056 2.094 0 0
Formation of the cornified envelope R-HSA-6809371 0.010649 1.973 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 0.018824 1.725 0 0
Diseases of Telomere Maintenance R-HSA-9673013 0.018824 1.725 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 0.018824 1.725 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 0.018824 1.725 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 0.018824 1.725 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 0.015202 1.818 0 0
mRNA Splicing - Major Pathway R-HSA-72163 0.016702 1.777 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 0.014471 1.840 0 0
Formation of the anterior neural plate R-HSA-9823739 0.014387 1.842 0 0
Signaling by Hippo R-HSA-2028269 0.018936 1.723 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 0.046403 1.333 0 0
Invadopodia formation R-HSA-8941237 0.046403 1.333 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 0.055424 1.256 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 0.064359 1.191 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 0.064359 1.191 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 0.064359 1.191 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 0.073211 1.135 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 0.073211 1.135 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 0.107794 0.967 0 0
ALK mutants bind TKIs R-HSA-9700645 0.107794 0.967 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 0.029565 1.529 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 0.132887 0.877 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 0.149225 0.826 0 0
Translesion synthesis by POLI R-HSA-5656121 0.173161 0.762 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 0.173161 0.762 0 0
Translesion synthesis by POLK R-HSA-5655862 0.180989 0.742 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 0.188745 0.724 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 0.196427 0.707 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 0.074223 1.129 0 0
Regulation of signaling by CBL R-HSA-912631 0.204037 0.690 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 0.204037 0.690 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 0.219042 0.659 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 0.042727 1.369 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 0.226439 0.645 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 0.226439 0.645 0 0
FGFR2 alternative splicing R-HSA-6803529 0.233767 0.631 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 0.241026 0.618 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 0.241026 0.618 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 0.055172 1.258 0 0
mRNA 3'-end processing R-HSA-72187 0.111891 0.951 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 0.124312 0.905 0 0
Dual incision in TC-NER R-HSA-6782135 0.130642 0.884 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 0.269383 0.570 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 0.269383 0.570 0 0
snRNP Assembly R-HSA-191859 0.133834 0.873 0 0
Metabolism of non-coding RNA R-HSA-194441 0.133834 0.873 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 0.276306 0.559 0 0
HIV elongation arrest and recovery R-HSA-167287 0.276306 0.559 0 0
Formation of the Early Elongation Complex R-HSA-113418 0.276306 0.559 0 0
Pausing and recovery of HIV elongation R-HSA-167290 0.276306 0.559 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 0.289958 0.538 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 0.296687 0.528 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 0.296687 0.528 0 0
mRNA Splicing R-HSA-72172 0.020786 1.682 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 0.309957 0.509 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 0.309957 0.509 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 0.316498 0.500 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 0.186923 0.728 0 0
Post-translational protein phosphorylation R-HSA-8957275 0.277395 0.557 0 0
EGFR downregulation R-HSA-182971 0.296687 0.528 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 0.196427 0.707 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 0.316498 0.500 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 0.149225 0.826 0 0
mRNA Capping R-HSA-72086 0.283164 0.548 0 0
Termination of translesion DNA synthesis R-HSA-5656169 0.044264 1.354 0 0
Activation of the pre-replicative complex R-HSA-68962 0.046545 1.332 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 0.322978 0.491 0 0
Receptor Mediated Mitophagy R-HSA-8934903 0.116238 0.935 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 0.076950 1.114 0 0
DNA Damage Bypass R-HSA-73893 0.102807 0.988 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 0.248216 0.605 0 0
Regulation of CDH11 function R-HSA-9762292 0.116238 0.935 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 0.124602 0.904 0 0
Translesion synthesis by REV1 R-HSA-110312 0.165257 0.782 0 0
Regulation of gap junction activity R-HSA-191650 0.055424 1.256 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 0.141095 0.850 0 0
Leading Strand Synthesis R-HSA-69109 0.141095 0.850 0 0
Polymerase switching R-HSA-69091 0.141095 0.850 0 0
Translesion Synthesis by POLH R-HSA-110320 0.204037 0.690 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 0.173355 0.761 0 0
DAP12 signaling R-HSA-2424491 0.289958 0.538 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 0.027660 1.558 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 0.020570 1.687 0 0
Calcineurin activates NFAT R-HSA-2025928 0.107794 0.967 0 0
COPI-mediated anterograde transport R-HSA-6807878 0.082773 1.082 0 0
Dual Incision in GG-NER R-HSA-5696400 0.322978 0.491 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 0.165257 0.782 0 0
Integrin signaling R-HSA-354192 0.309957 0.509 0 0
Regulation of endogenous retroelements R-HSA-9842860 0.291406 0.536 0 0
Nucleotide Excision Repair R-HSA-5696398 0.305384 0.515 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 0.270383 0.568 0 0
Nuclear Envelope Breakdown R-HSA-2980766 0.024601 1.609 0 0
FGFR1 mutant receptor activation R-HSA-1839124 0.309957 0.509 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 0.055424 1.256 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 0.064359 1.191 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 0.180989 0.742 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 0.196427 0.707 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 0.204037 0.690 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 0.255338 0.593 0 0
Viral Messenger RNA Synthesis R-HSA-168325 0.140272 0.853 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 0.166634 0.778 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 0.322978 0.491 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 0.259862 0.585 0 0
DNA Replication Pre-Initiation R-HSA-69002 0.319312 0.496 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 0.167334 0.776 0 0
Negative regulation of MET activity R-HSA-6807004 0.211575 0.675 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 0.090666 1.043 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 0.116238 0.935 0 0
HDACs deacetylate histones R-HSA-3214815 0.121176 0.917 0 0
Diseases of mitotic cell cycle R-HSA-9675126 0.303354 0.518 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 0.176731 0.753 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 0.316498 0.500 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 0.044264 1.354 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 0.064359 1.191 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 0.064864 1.188 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 0.053640 1.271 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 0.276306 0.559 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 0.283164 0.548 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 0.322978 0.491 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 0.157279 0.803 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 0.309957 0.509 0 0
Parasite infection R-HSA-9664407 0.063685 1.196 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 0.063685 1.196 0 0
Leishmania phagocytosis R-HSA-9664417 0.063685 1.196 0 0
Keratinization R-HSA-6805567 0.065564 1.183 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 0.262394 0.581 0 0
Assembly of the pre-replicative complex R-HSA-68867 0.256356 0.591 0 0
DNA Replication R-HSA-69306 0.222526 0.653 0 0
Molecules associated with elastic fibres R-HSA-2129379 0.296687 0.528 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 0.157279 0.803 0 0
Nuclear import of Rev protein R-HSA-180746 0.322978 0.491 0 0
Spry regulation of FGF signaling R-HSA-1295596 0.165257 0.782 0 0
Lagging Strand Synthesis R-HSA-69186 0.219042 0.659 0 0
Mitophagy R-HSA-5205647 0.322978 0.491 0 0
Synthesis of DNA R-HSA-69239 0.105167 0.978 0 0
Metabolism of RNA R-HSA-8953854 0.192244 0.716 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 0.055424 1.256 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 0.099271 1.003 0 0
Sodium/Proton exchangers R-HSA-425986 0.099271 1.003 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 0.141095 0.850 0 0
Protein lipoylation R-HSA-9857492 0.165257 0.782 0 0
Differentiation of T cells R-HSA-9945266 0.173161 0.762 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 0.173161 0.762 0 0
Negative regulation of FLT3 R-HSA-9706369 0.173161 0.762 0 0
mTORC1-mediated signalling R-HSA-166208 0.233767 0.631 0 0
Orc1 removal from chromatin R-HSA-68949 0.111891 0.951 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 0.140272 0.853 0 0
Adherens junctions interactions R-HSA-418990 0.077821 1.109 0 0
Activation of ATR in response to replication stress R-HSA-176187 0.053640 1.271 0 0
Cell-cell junction organization R-HSA-421270 0.117351 0.931 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 0.107794 0.967 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 0.113033 0.947 0 0
Telomere Maintenance R-HSA-157579 0.084553 1.073 0 0
Mitotic Prophase R-HSA-68875 0.136064 0.866 0 0
ER to Golgi Anterograde Transport R-HSA-199977 0.207759 0.682 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 0.073211 1.135 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 0.116238 0.935 0 0
Regulation of PTEN gene transcription R-HSA-8943724 0.137045 0.863 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 0.309957 0.509 0 0
Switching of origins to a post-replicative state R-HSA-69052 0.180119 0.744 0 0
Cell junction organization R-HSA-446728 0.155512 0.808 0 0
Signaling by FGFR2 R-HSA-5654738 0.204081 0.690 0 0
DNA Repair R-HSA-73894 0.155020 0.810 0 0
Chromosome Maintenance R-HSA-73886 0.138226 0.859 0 0
ER-Phagosome pathway R-HSA-1236974 0.238848 0.622 0 0
Interferon Signaling R-HSA-913531 0.091905 1.037 0 0
Cell-Cell communication R-HSA-1500931 0.216515 0.665 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 0.173355 0.761 0 0
Signaling by FGFR in disease R-HSA-1226099 0.183516 0.736 0 0
Epigenetic regulation of gene expression R-HSA-212165 0.110023 0.959 0 0
Hyaluronan degradation R-HSA-2160916 0.255338 0.593 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 0.269383 0.570 0 0
Heme signaling R-HSA-9707616 0.143516 0.843 0 0
Interleukin-7 signaling R-HSA-1266695 0.255338 0.593 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 0.107794 0.967 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 0.226439 0.645 0 0
NRAGE signals death through JNK R-HSA-193648 0.124312 0.905 0 0
Triglyceride biosynthesis R-HSA-75109 0.269383 0.570 0 0
Potential therapeutics for SARS R-HSA-9679191 0.022786 1.642 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 0.211575 0.675 0 0
Signaling by MET R-HSA-6806834 0.204081 0.690 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 0.248216 0.605 0 0
Neurodegenerative Diseases R-HSA-8863678 0.248216 0.605 0 0
Hyaluronan metabolism R-HSA-2142845 0.322978 0.491 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 0.219042 0.659 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 0.219042 0.659 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 0.275595 0.560 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 0.275595 0.560 0 0
S Phase R-HSA-69242 0.210205 0.677 0 0
Regulation of KIT signaling R-HSA-1433559 0.157279 0.803 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 0.255338 0.593 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 0.269383 0.570 0 0
Antigen processing-Cross presentation R-HSA-1236975 0.315836 0.501 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 0.085316 1.069 0 0
Synthesis of PE R-HSA-1483213 0.269383 0.570 0 0
Signaling by FGFR R-HSA-190236 0.277395 0.557 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 0.233767 0.631 0 0
Activation of BH3-only proteins R-HSA-114452 0.289958 0.538 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 0.070927 1.149 0 0
Signaling by LTK R-HSA-9842663 0.141095 0.850 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 0.149225 0.826 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 0.211575 0.675 0 0
Mitochondrial calcium ion transport R-HSA-8949215 0.226439 0.645 0 0
Complex III assembly R-HSA-9865881 0.248216 0.605 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 0.255338 0.593 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 0.255338 0.593 0 0
Gene Silencing by RNA R-HSA-211000 0.312355 0.505 0 0
Signaling by EGFR in Cancer R-HSA-1643713 0.262394 0.581 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 0.137045 0.863 0 0
Parasitic Infection Pathways R-HSA-9824443 0.321112 0.493 0 0
Leishmania infection R-HSA-9658195 0.321112 0.493 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 0.262394 0.581 0 0
SARS-CoV-2-host interactions R-HSA-9705683 0.088915 1.051 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 0.169988 0.770 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 0.048869 1.311 0 0
Signaling by PDGFR in disease R-HSA-9671555 0.226439 0.645 0 0
Innate Immune System R-HSA-168249 0.031638 1.500 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 0.141095 0.850 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 0.255338 0.593 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 0.322978 0.491 0 0
Immune System R-HSA-168256 0.071784 1.144 0 0
RSV-host interactions R-HSA-9833110 0.099361 1.003 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 0.116238 0.935 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 0.309957 0.509 0 0
Signaling by ALK in cancer R-HSA-9700206 0.027527 1.560 0 0
DNA Double-Strand Break Repair R-HSA-5693532 0.222526 0.653 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 0.061088 1.214 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 0.255338 0.593 0 0
G alpha (12/13) signalling events R-HSA-416482 0.197195 0.705 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 0.195635 0.709 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 0.027527 1.560 0 0
DNA Damage Reversal R-HSA-73942 0.165257 0.782 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 0.099827 1.001 0 0
MITF-M-dependent gene expression R-HSA-9856651 0.022786 1.642 0 0
Signal Transduction R-HSA-162582 0.230092 0.638 1 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 0.180119 0.744 0 0
Chromatin organization R-HSA-4839726 0.253611 0.596 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 0.188745 0.724 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 0.188745 0.724 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 0.051234 1.290 0 0
Interleukin-6 signaling R-HSA-1059683 0.149225 0.826 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 0.273889 0.562 0 0
Dissolution of Fibrin Clot R-HSA-75205 0.124602 0.904 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 0.072572 1.139 0 0
Apoptotic execution phase R-HSA-75153 0.093942 1.027 0 0
Extracellular matrix organization R-HSA-1474244 0.242445 0.615 0 0
Interleukin-6 family signaling R-HSA-6783589 0.248216 0.605 0 0
SARS-CoV-2 Infection R-HSA-9694516 0.274589 0.561 0 0
Apoptosis R-HSA-109581 0.245047 0.611 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 0.153340 0.814 0 0
SARS-CoV Infections R-HSA-9679506 0.183720 0.736 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 0.125438 0.902 0 0
Signaling by VEGF R-HSA-194138 0.149207 0.826 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 0.280900 0.551 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 0.181332 0.742 0 0
Interleukin-12 signaling R-HSA-9020591 0.190338 0.720 0 0
Interleukin-12 family signaling R-HSA-447115 0.231861 0.635 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 0.329397 0.482 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 0.329397 0.482 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 0.334977 0.475 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 0.335755 0.474 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 0.335755 0.474 0 0
FGFR2 mutant receptor activation R-HSA-1839126 0.335755 0.474 0 0
GPVI-mediated activation cascade R-HSA-114604 0.335755 0.474 0 0
RNA Polymerase III Transcription R-HSA-74158 0.335755 0.474 0 0
FLT3 signaling in disease R-HSA-9682385 0.335755 0.474 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 0.339241 0.469 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 0.340076 0.468 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 0.342053 0.466 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 0.342053 0.466 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 0.342053 0.466 0 0
Metabolism of folate and pterines R-HSA-196757 0.342053 0.466 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 0.345326 0.462 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 0.346957 0.460 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 0.348292 0.458 0 0
Elastic fibre formation R-HSA-1566948 0.348292 0.458 0 0
MET promotes cell motility R-HSA-8875878 0.348292 0.458 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 0.350496 0.455 0 0
PIP3 activates AKT signaling R-HSA-1257604 0.351159 0.454 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 0.354472 0.450 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 0.354472 0.450 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 0.354472 0.450 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 0.354472 0.450 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 0.354472 0.450 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 0.357233 0.447 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 0.360594 0.443 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 0.360594 0.443 0 0
HIV Transcription Elongation R-HSA-167169 0.360594 0.443 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 0.360594 0.443 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 0.360594 0.443 0 0
Generation of second messenger molecules R-HSA-202433 0.360594 0.443 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 0.360594 0.443 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 0.360594 0.443 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 0.360594 0.443 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 0.360594 0.443 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 0.360594 0.443 0 0
Diseases of Immune System R-HSA-5260271 0.360594 0.443 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 0.360594 0.443 0 0
Programmed Cell Death R-HSA-5357801 0.360823 0.443 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 0.366658 0.436 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 0.366658 0.436 0 0
FLT3 Signaling R-HSA-9607240 0.366658 0.436 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 0.366658 0.436 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 0.367451 0.435 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 0.372665 0.429 0 0
HIV Transcription Initiation R-HSA-167161 0.372665 0.429 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 0.372665 0.429 0 0
MAP2K and MAPK activation R-HSA-5674135 0.372665 0.429 0 0
Signaling by RAF1 mutants R-HSA-9656223 0.372665 0.429 0 0
Signaling by FGFR1 in disease R-HSA-5655302 0.372665 0.429 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 0.372665 0.429 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 0.374229 0.427 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 0.378616 0.422 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 0.378616 0.422 0 0
MTOR signalling R-HSA-165159 0.378616 0.422 0 0
G1/S Transition R-HSA-69206 0.384340 0.415 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 0.384510 0.415 0 0
Signaling by FGFR4 R-HSA-5654743 0.384510 0.415 0 0
Signaling by SCF-KIT R-HSA-1433557 0.384510 0.415 0 0
Cell Cycle R-HSA-1640170 0.390048 0.409 0 0
DAP12 interactions R-HSA-2172127 0.390349 0.409 0 0
Proteasome assembly R-HSA-9907900 0.390349 0.409 0 0
Platelet degranulation R-HSA-114608 0.391042 0.408 0 0
G2/M Checkpoints R-HSA-69481 0.391042 0.408 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 0.396133 0.402 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 0.396133 0.402 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 0.396133 0.402 0 0
Signaling by FGFR3 R-HSA-5654741 0.396133 0.402 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 0.397584 0.401 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 0.401035 0.397 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 0.401862 0.396 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 0.401862 0.396 0 0
Signaling downstream of RAS mutants R-HSA-9649948 0.401862 0.396 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 0.401862 0.396 0 0
Signaling by RAS mutants R-HSA-6802949 0.401862 0.396 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 0.401862 0.396 0 0
Regulation of pyruvate metabolism R-HSA-9861718 0.401862 0.396 1 0
Synthesis of PC R-HSA-1483191 0.407538 0.390 0 0
Degradation of the extracellular matrix R-HSA-1474228 0.410951 0.386 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 0.413159 0.384 0 0
Metal ion SLC transporters R-HSA-425410 0.413159 0.384 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 0.414238 0.383 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 0.414518 0.382 0 0
Degradation of CDH1 R-HSA-9766229 0.418728 0.378 0 0
Gap junction trafficking and regulation R-HSA-157858 0.418728 0.378 0 0
Signaling by FGFR2 in disease R-HSA-5655253 0.424245 0.372 0 0
Chromatin modifying enzymes R-HSA-3247509 0.434627 0.362 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 0.435122 0.361 0 0
PTEN Regulation R-HSA-6807070 0.436992 0.360 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 0.440483 0.356 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 0.440483 0.356 0 0
Smooth Muscle Contraction R-HSA-445355 0.440483 0.356 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 0.445795 0.351 0 0
Late Phase of HIV Life Cycle R-HSA-162599 0.449780 0.347 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 0.451056 0.346 0 0
Intracellular signaling by second messengers R-HSA-9006925 0.451338 0.345 0 0
Signaling by EGFR R-HSA-177929 0.456267 0.341 0 0
Signaling by FGFR1 R-HSA-5654736 0.456267 0.341 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 0.456267 0.341 0 0
Regulation of CDH1 Function R-HSA-9764561 0.461429 0.336 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 0.462405 0.335 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 0.466543 0.331 0 0
Cytokine Signaling in Immune system R-HSA-1280215 0.469112 0.329 0 0
Extension of Telomeres R-HSA-180786 0.471608 0.326 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 0.471608 0.326 0 0
Triglyceride metabolism R-HSA-8979227 0.471608 0.326 0 0
Gastrulation R-HSA-9758941 0.471762 0.326 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 0.476626 0.322 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 0.477947 0.321 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 0.481022 0.318 0 0
Collagen degradation R-HSA-1442490 0.481596 0.317 0 0
Cell Cycle, Mitotic R-HSA-69278 0.486101 0.313 0 0
Deubiquitination R-HSA-5688426 0.486117 0.313 0 0
tRNA processing in the nucleus R-HSA-6784531 0.486520 0.313 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 0.486520 0.313 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 0.487141 0.312 0 0
Death Receptor Signaling R-HSA-73887 0.487141 0.312 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 0.490183 0.310 0 0
Complex I biogenesis R-HSA-6799198 0.491396 0.309 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 0.491396 0.309 0 0
Signaling by PTK6 R-HSA-8848021 0.491396 0.309 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 0.491396 0.309 0 0
Cell Cycle Checkpoints R-HSA-69620 0.493294 0.307 0 0
Ion transport by P-type ATPases R-HSA-936837 0.496227 0.304 0 0
HIV Life Cycle R-HSA-162587 0.496234 0.304 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 0.499243 0.302 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 0.501013 0.300 0 0
Interferon gamma signaling R-HSA-877300 0.502240 0.299 0 0
Signaling by TGFB family members R-HSA-9006936 0.505226 0.297 0 0
Regulation of TP53 Activity R-HSA-5633007 0.505226 0.297 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 0.505753 0.296 0 0
DNA Double Strand Break Response R-HSA-5693606 0.510448 0.292 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 0.510448 0.292 0 0
Transcription of the HIV genome R-HSA-167172 0.515099 0.288 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 0.515099 0.288 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 0.515099 0.288 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 0.524270 0.280 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 0.524270 0.280 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 0.528791 0.277 0 0
Platelet activation, signaling and aggregation R-HSA-76002 0.530716 0.275 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 0.533269 0.273 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 0.533269 0.273 0 0
Ca2+ pathway R-HSA-4086398 0.537704 0.269 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 0.542098 0.266 0 0
Ub-specific processing proteases R-HSA-5689880 0.545796 0.263 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 0.546450 0.262 0 0
ISG15 antiviral mechanism R-HSA-1169408 0.546450 0.262 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 0.548847 0.261 0 0
UCH proteinases R-HSA-5689603 0.550761 0.259 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 0.550761 0.259 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 0.551401 0.259 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 0.559262 0.252 0 0
RNA Polymerase I Transcription R-HSA-73864 0.559262 0.252 0 0
Integrin cell surface interactions R-HSA-216083 0.559262 0.252 0 0
Respiratory electron transport R-HSA-611105 0.559718 0.252 0 0
Influenza Infection R-HSA-168255 0.562466 0.250 0 0
Sensory processing of sound R-HSA-9659379 0.563452 0.249 0 0
Adaptive Immune System R-HSA-1280218 0.564039 0.249 0 0
Infectious disease R-HSA-5663205 0.566448 0.247 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 0.567603 0.246 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 0.567603 0.246 0 0
Amyloid fiber formation R-HSA-977225 0.571714 0.243 0 0
Cytoprotection by HMOX1 R-HSA-9707564 0.579821 0.237 0 0
Signaling by Interleukins R-HSA-449147 0.579864 0.237 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 0.583817 0.234 0 0
Oncogenic MAPK signaling R-HSA-6802957 0.587775 0.231 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 0.591696 0.228 0 0
Amplification of signal from the kinetochores R-HSA-141424 0.591696 0.228 0 0
Cilium Assembly R-HSA-5617833 0.591887 0.228 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 0.595579 0.225 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 0.597076 0.224 0 0
Pyruvate metabolism R-HSA-70268 0.599426 0.222 1 0
Selective autophagy R-HSA-9663891 0.603237 0.220 0 0
Diseases of programmed cell death R-HSA-9645723 0.603237 0.220 0 0
Developmental Biology R-HSA-1266738 0.605219 0.218 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 0.610751 0.214 0 0
Base Excision Repair R-HSA-73884 0.610751 0.214 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 0.624740 0.204 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 0.625357 0.204 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 0.632454 0.199 0 0
Post-translational protein modification R-HSA-597592 0.639173 0.194 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 0.639418 0.194 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 0.642850 0.192 0 0
Mitotic Spindle Checkpoint R-HSA-69618 0.652955 0.185 0 0
Glycolysis R-HSA-70171 0.652955 0.185 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 0.656259 0.183 0 0
Viral Infection Pathways R-HSA-9824446 0.657199 0.182 0 0
Mitotic Anaphase R-HSA-68882 0.657809 0.182 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 0.659533 0.181 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 0.659533 0.181 0 0
PI Metabolism R-HSA-1483255 0.659533 0.181 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 0.660081 0.180 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 0.662775 0.179 0 0
Response of endothelial cells to shear stress R-HSA-9860931 0.665986 0.177 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 0.665986 0.177 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 0.669096 0.175 1 0
Activation of HOX genes during differentiation R-HSA-5619507 0.669168 0.174 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 0.669168 0.174 0 0
HIV Infection R-HSA-162906 0.682138 0.166 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 0.684628 0.165 0 0
TCR signaling R-HSA-202403 0.687633 0.163 0 0
Antimicrobial peptides R-HSA-6803157 0.690609 0.161 0 0
FCERI mediated MAPK activation R-HSA-2871796 0.693558 0.159 0 0
Inositol phosphate metabolism R-HSA-1483249 0.693558 0.159 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 0.699370 0.155 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 0.699370 0.155 0 0
ESR-mediated signaling R-HSA-8939211 0.703020 0.153 0 0
Cap-dependent Translation Initiation R-HSA-72737 0.710670 0.148 0 0
Eukaryotic Translation Initiation R-HSA-72613 0.710670 0.148 0 0
Glucose metabolism R-HSA-70326 0.713428 0.147 0 0
Gene expression (Transcription) R-HSA-74160 0.715957 0.145 0 0
Homology Directed Repair R-HSA-5693538 0.716160 0.145 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 0.718866 0.143 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 0.718866 0.143 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 0.724202 0.140 0 0
Cellular response to heat stress R-HSA-3371556 0.724202 0.140 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 0.726832 0.139 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 0.726832 0.139 0 0
MHC class II antigen presentation R-HSA-2132295 0.729437 0.137 0 0
Host Interactions of HIV factors R-HSA-162909 0.732018 0.135 0 0
Regulation of Complement cascade R-HSA-977606 0.734574 0.134 0 0
M Phase R-HSA-68886 0.739448 0.131 0 0
Developmental Cell Lineages R-HSA-9734767 0.752045 0.124 0 0
Adipogenesis R-HSA-9843745 0.754169 0.123 0 0
Cellular response to chemical stress R-HSA-9711123 0.760639 0.119 0 0
Membrane Trafficking R-HSA-199991 0.765714 0.116 0 0
Estrogen-dependent gene expression R-HSA-9018519 0.767916 0.115 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 0.767916 0.115 0 0
Mitochondrial translation R-HSA-5368287 0.772326 0.112 0 0
Disease R-HSA-1643685 0.775231 0.111 0 0
Macroautophagy R-HSA-1632852 0.778786 0.109 0 0
Hemostasis R-HSA-109582 0.781457 0.107 0 0
Clathrin-mediated endocytosis R-HSA-8856828 0.785064 0.105 0 0
Complement cascade R-HSA-166658 0.789150 0.103 0 0
RAF/MAP kinase cascade R-HSA-5673001 0.793987 0.100 0 0
Asparagine N-linked glycosylation R-HSA-446203 0.795004 0.100 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 0.795136 0.100 0 0
Phospholipid metabolism R-HSA-1483257 0.802736 0.095 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 0.804162 0.095 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 0.806605 0.093 0 0
Autophagy R-HSA-9612973 0.810284 0.091 0 0
HCMV Late Events R-HSA-9610379 0.812098 0.090 0 0
Separation of Sister Chromatids R-HSA-2467813 0.824320 0.084 0 0
SLC transporter disorders R-HSA-5619102 0.829313 0.081 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 0.835751 0.078 0 0
tRNA processing R-HSA-72306 0.835751 0.078 0 0
Organelle biogenesis and maintenance R-HSA-1852241 0.835756 0.078 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 0.837323 0.077 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 0.838880 0.076 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 0.843427 0.074 0 0
Cellular Senescence R-HSA-2559583 0.850812 0.070 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 0.861865 0.065 0 0
Ion channel transport R-HSA-983712 0.863189 0.064 0 0
MAPK family signaling cascades R-HSA-5683057 0.865769 0.063 0 0
Toll-like Receptor Cascades R-HSA-168898 0.865797 0.063 0 0
Mitotic Prometaphase R-HSA-68877 0.868357 0.061 0 0
Glycosaminoglycan metabolism R-HSA-1630316 0.868357 0.061 0 0
HCMV Early Events R-HSA-9609690 0.872105 0.059 0 0
Co-inhibition by PD-1 R-HSA-389948 0.876939 0.057 0 0
Signaling by ROBO receptors R-HSA-376176 0.880444 0.055 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 0.880444 0.055 0 0
Signaling by Nuclear Receptors R-HSA-9006931 0.881110 0.055 1 0
Muscle contraction R-HSA-397014 0.891428 0.050 0 0
Vesicle-mediated transport R-HSA-5653656 0.899221 0.046 0 0
Neddylation R-HSA-8951664 0.900453 0.046 0 0
Bacterial Infection Pathways R-HSA-9824439 0.904138 0.044 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 0.907848 0.042 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 0.908733 0.042 0 0
rRNA processing R-HSA-72312 0.910478 0.041 0 0
Disorders of transmembrane transporters R-HSA-5619115 0.922550 0.035 0 0
HCMV Infection R-HSA-9609646 0.924763 0.034 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 0.929002 0.032 0 0
Translation R-HSA-72766 0.929374 0.032 0 0
Cellular responses to stimuli R-HSA-8953897 0.931902 0.031 0 0
Cellular responses to stress R-HSA-2262752 0.934280 0.030 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 0.942578 0.026 0 0
Signaling by WNT R-HSA-195721 0.952719 0.021 0 0
Metabolism of proteins R-HSA-392499 0.962141 0.017 0 0
RNA Polymerase II Transcription R-HSA-73857 0.969749 0.013 0 0
Metabolism of vitamins and cofactors R-HSA-196854 0.975096 0.011 0 0
SLC-mediated transmembrane transport R-HSA-425407 0.982119 0.008 0 0
Fatty acid metabolism R-HSA-8978868 0.983781 0.007 0 0
Generic Transcription Pathway R-HSA-212436 0.985412 0.006 0 0
Signaling by GPCR R-HSA-372790 0.990875 0.004 0 0
Axon guidance R-HSA-422475 0.995808 0.002 0 0
GPCR downstream signalling R-HSA-388396 0.996133 0.002 0 0
Transport of small molecules R-HSA-382551 0.996643 0.001 0 0
Nervous system development R-HSA-9675108 0.997089 0.001 0 0
GPCR ligand binding R-HSA-500792 0.997284 0.001 0 0
Metabolism of lipids R-HSA-556833 0.999959 0.000 0 0
Sensory Perception R-HSA-9709957 0.999996 0.000 0 0
Metabolism R-HSA-1430728 1.000000 0.000 1 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 1.000000 0.000 1 1
Signaling by Retinoic Acid R-HSA-5362517 1.000000 0.000 1 1
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Attenuation phase R-HSA-3371568 1.113887e-12 11.953 0 0
HSF1-dependent transactivation R-HSA-3371571 2.182188e-11 10.661 0 0
Cellular response to heat stress R-HSA-3371556 3.334139e-10 9.477 0 0
HSF1 activation R-HSA-3371511 1.441047e-09 8.841 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.398906e-09 8.854 0 0
Cellular responses to stimuli R-HSA-8953897 2.265049e-08 7.645 0 0
Cellular responses to stress R-HSA-2262752 2.034725e-07 6.691 0 0
Regulation of CDH1 Function R-HSA-9764561 8.389540e-07 6.076 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 2.509317e-06 5.600 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 8.566828e-06 5.067 0 0
Cell Cycle R-HSA-1640170 7.985294e-06 5.098 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.020774e-05 4.991 0 0
Cell Cycle, Mitotic R-HSA-69278 1.603051e-05 4.795 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 2.331451e-05 4.632 0 0
Axon guidance R-HSA-422475 2.279360e-05 4.642 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 3.227438e-05 4.491 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 3.251023e-05 4.488 0 0
Translation initiation complex formation R-HSA-72649 3.650221e-05 4.438 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 4.551105e-05 4.342 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 4.162675e-05 4.381 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 4.578752e-05 4.339 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 4.162675e-05 4.381 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 5.630227e-05 4.249 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 6.651631e-05 4.177 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 7.558837e-05 4.122 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 7.558837e-05 4.122 0 0
Signaling by ERBB2 R-HSA-1227986 6.914311e-05 4.160 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 7.307854e-05 4.136 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 7.307854e-05 4.136 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 6.569708e-05 4.182 0 0
Nervous system development R-HSA-9675108 6.605852e-05 4.180 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 8.806829e-05 4.055 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 9.289887e-05 4.032 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 9.289887e-05 4.032 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.122134e-04 3.950 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.087427e-04 3.964 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.230487e-04 3.910 0 0
M Phase R-HSA-68886 1.597400e-04 3.797 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.831544e-04 3.737 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 2.077511e-04 3.682 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 2.077511e-04 3.682 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.256710e-04 3.647 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 2.256710e-04 3.647 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.414328e-04 3.617 0 0
Centrosome maturation R-HSA-380287 2.653196e-04 3.576 0 0
Signal Transduction R-HSA-162582 2.715125e-04 3.566 1 0
Apoptosis R-HSA-109581 2.661124e-04 3.575 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 3.649935e-04 3.438 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 3.803859e-04 3.420 0 0
Oncogenic MAPK signaling R-HSA-6802957 5.582756e-04 3.253 0 0
Developmental Cell Lineages R-HSA-9734767 5.388831e-04 3.269 0 0
G2/M Checkpoints R-HSA-69481 5.624166e-04 3.250 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 5.205907e-04 3.284 0 0
Semaphorin interactions R-HSA-373755 5.586243e-04 3.253 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 5.586243e-04 3.253 0 0
Signaling by PTK6 R-HSA-8848021 5.586243e-04 3.253 0 0
Developmental Biology R-HSA-1266738 5.315829e-04 3.274 0 0
Programmed Cell Death R-HSA-5357801 5.732041e-04 3.242 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 5.757225e-04 3.240 0 0
Prolonged ERK activation events R-HSA-169893 6.961618e-04 3.157 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 6.788041e-04 3.168 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 7.317126e-04 3.136 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 7.770381e-04 3.110 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 7.908820e-04 3.102 0 0
Activation of BH3-only proteins R-HSA-114452 7.770381e-04 3.110 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 8.333914e-04 3.079 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 8.334183e-04 3.079 0 0
Gluconeogenesis R-HSA-70263 9.032241e-04 3.044 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 9.866915e-04 3.006 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 9.887272e-04 3.005 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.034668e-03 2.985 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.163326e-03 2.934 0 0
Signaling by ERBB4 R-HSA-1236394 1.278806e-03 2.893 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.390242e-03 2.857 0 0
Manipulation of host energy metabolism R-HSA-9636667 1.640905e-03 2.785 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.575329e-03 2.803 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.592498e-03 2.798 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.592498e-03 2.798 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 1.692375e-03 2.772 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.868985e-03 2.728 0 0
Platelet activation, signaling and aggregation R-HSA-76002 2.197170e-03 2.658 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 2.879932e-03 2.541 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 2.879932e-03 2.541 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 2.879932e-03 2.541 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 2.879932e-03 2.541 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 2.879932e-03 2.541 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 2.879932e-03 2.541 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 2.879932e-03 2.541 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 2.879932e-03 2.541 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 2.879932e-03 2.541 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 2.879932e-03 2.541 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 2.879932e-03 2.541 0 0
PECAM1 interactions R-HSA-210990 2.745652e-03 2.561 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 2.744348e-03 2.562 0 0
Signaling by RAF1 mutants R-HSA-9656223 2.960147e-03 2.529 0 0
MAP2K and MAPK activation R-HSA-5674135 2.960147e-03 2.529 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 2.744348e-03 2.562 0 0
MAPK family signaling cascades R-HSA-5683057 2.630185e-03 2.580 0 0
Adherens junctions interactions R-HSA-418990 2.829507e-03 2.548 0 0
Cell-cell junction organization R-HSA-421270 2.932384e-03 2.533 0 0
G2/M Transition R-HSA-69275 2.627942e-03 2.580 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.827029e-03 2.549 0 0
Cell-Cell communication R-HSA-1500931 2.844129e-03 2.546 0 0
XBP1(S) activates chaperone genes R-HSA-381038 2.897851e-03 2.538 0 0
Neutrophil degranulation R-HSA-6798695 3.025812e-03 2.519 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 3.223970e-03 2.492 0 0
Sema4D in semaphorin signaling R-HSA-400685 3.401158e-03 2.468 0 0
Long-term potentiation R-HSA-9620244 3.401158e-03 2.468 0 0
RAF/MAP kinase cascade R-HSA-5673001 3.411668e-03 2.467 0 0
TRKA activation by NGF R-HSA-187042 4.442550e-03 2.352 0 0
Axonal growth stimulation R-HSA-209563 4.442550e-03 2.352 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 4.237671e-03 2.373 0 0
Signaling downstream of RAS mutants R-HSA-9649948 4.450170e-03 2.352 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 4.802269e-03 2.319 0 0
EPH-Ephrin signaling R-HSA-2682334 4.253762e-03 2.371 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 4.450170e-03 2.352 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 4.450170e-03 2.352 0 0
Frs2-mediated activation R-HSA-170968 4.709900e-03 2.327 0 0
EPHB-mediated forward signaling R-HSA-3928662 3.801756e-03 2.420 0 0
Signaling by RAS mutants R-HSA-6802949 4.450170e-03 2.352 0 0
Cap-dependent Translation Initiation R-HSA-72737 4.415841e-03 2.355 0 0
Eukaryotic Translation Initiation R-HSA-72613 4.415841e-03 2.355 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 4.442550e-03 2.352 0 0
Somitogenesis R-HSA-9824272 4.116852e-03 2.385 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 4.220153e-03 2.375 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 4.142037e-03 2.383 0 0
L1CAM interactions R-HSA-373760 4.415841e-03 2.355 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 3.748500e-03 2.426 0 0
Apoptotic execution phase R-HSA-75153 4.450170e-03 2.352 0 0
IRE1alpha activates chaperones R-HSA-381070 4.035316e-03 2.394 0 0
Formation of a pool of free 40S subunits R-HSA-72689 5.218088e-03 2.282 0 0
Mitotic Prophase R-HSA-68875 5.269242e-03 2.278 0 0
G2/M DNA damage checkpoint R-HSA-69473 5.870045e-03 2.231 0 0
Signaling by NOTCH4 R-HSA-9013694 5.870045e-03 2.231 0 0
MITF-M-dependent gene expression R-HSA-9856651 6.303320e-03 2.200 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 6.315880e-03 2.200 0 0
Cell junction organization R-HSA-446728 6.366720e-03 2.196 0 0
Signaling by VEGF R-HSA-194138 6.778851e-03 2.169 0 0
DNA strand elongation R-HSA-69190 6.910560e-03 2.160 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 7.290548e-03 2.137 0 0
Smooth Muscle Contraction R-HSA-445355 7.340181e-03 2.134 0 0
Platelet degranulation R-HSA-114608 7.348432e-03 2.134 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 8.387126e-03 2.076 0 0
Cell Cycle Checkpoints R-HSA-69620 9.275335e-03 2.033 0 0
PKR-mediated signaling R-HSA-9833482 8.150193e-03 2.089 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 8.906710e-03 2.050 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 9.476427e-03 2.023 0 0
Signaling by Hippo R-HSA-2028269 9.507392e-03 2.022 0 0
Mitotic Prometaphase R-HSA-68877 9.562140e-03 2.019 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.629123e-03 2.016 0 0
Signalling to ERKs R-HSA-187687 9.711888e-03 2.013 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.071078e-02 1.970 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.071078e-02 1.970 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.094501e-02 1.961 0 0
Regulation of signaling by CBL R-HSA-912631 1.199836e-02 1.921 0 0
Rap1 signalling R-HSA-392517 1.199836e-02 1.921 0 0
Formation of paraxial mesoderm R-HSA-9793380 1.200607e-02 1.921 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.270352e-02 1.896 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.316253e-02 1.881 0 0
Formation of definitive endoderm R-HSA-9823730 1.337104e-02 1.874 0 0
Aggrephagy R-HSA-9646399 1.413226e-02 1.850 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 1.368977e-02 1.864 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.637453e-02 1.786 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.592167e-02 1.798 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.623628e-02 1.790 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.482956e-02 1.829 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.585197e-02 1.800 0 0
SARS-CoV-2 Infection R-HSA-9694516 1.472066e-02 1.832 0 0
Activation of TRKA receptors R-HSA-187015 1.667160e-02 1.778 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 1.667160e-02 1.778 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 1.667160e-02 1.778 0 0
Muscle contraction R-HSA-397014 1.688991e-02 1.772 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.730870e-02 1.762 0 0
Gastrulation R-HSA-9758941 1.787524e-02 1.748 0 0
mTORC1-mediated signalling R-HSA-166208 1.800642e-02 1.745 0 0
Response of Mtb to phagocytosis R-HSA-9637690 1.845849e-02 1.734 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.903183e-02 1.721 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.965461e-02 1.707 0 0
Formation of annular gap junctions R-HSA-196025 1.991804e-02 1.701 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 1.991804e-02 1.701 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.028998e-02 1.693 0 0
G1/S Transition R-HSA-69206 2.113865e-02 1.675 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 2.153216e-02 1.667 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 2.218768e-02 1.654 0 0
Glycolysis R-HSA-70171 2.281134e-02 1.642 0 0
Membrane Trafficking R-HSA-199991 2.321779e-02 1.634 0 0
ARMS-mediated activation R-HSA-170984 2.340544e-02 1.631 0 0
Gap junction degradation R-HSA-190873 2.340544e-02 1.631 0 0
p75NTR regulates axonogenesis R-HSA-193697 2.340544e-02 1.631 0 0
Unwinding of DNA R-HSA-176974 2.340544e-02 1.631 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 2.340544e-02 1.631 0 0
Recycling pathway of L1 R-HSA-437239 2.352544e-02 1.628 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.460452e-02 1.609 0 0
PI3K/AKT activation R-HSA-198203 2.712335e-02 1.567 0 0
Synthesis of DNA R-HSA-69239 3.054186e-02 1.515 0 0
Orc1 removal from chromatin R-HSA-68949 3.093964e-02 1.509 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 2.494430e-02 1.603 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 2.712335e-02 1.567 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 3.093964e-02 1.509 0 0
Cellular response to chemical stress R-HSA-9711123 2.748774e-02 1.561 0 0
SARS-CoV-2-host interactions R-HSA-9705683 2.524420e-02 1.598 0 0
SARS-CoV-1-host interactions R-HSA-9692914 2.949304e-02 1.530 0 0
Suppression of apoptosis R-HSA-9635465 3.106161e-02 1.508 0 0
Signaling by ROBO receptors R-HSA-376176 3.182666e-02 1.497 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 3.256934e-02 1.487 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 3.293000e-02 1.482 0 0
Signaling by NOTCH R-HSA-157118 3.321491e-02 1.479 0 0
mRNA Splicing R-HSA-72172 3.339250e-02 1.476 0 0
Unfolded Protein Response (UPR) R-HSA-381119 3.491169e-02 1.457 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 3.521039e-02 1.453 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 3.521039e-02 1.453 0 0
SARS-CoV Infections R-HSA-9679506 3.526815e-02 1.453 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 3.662087e-02 1.436 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 3.825060e-02 1.417 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 3.825060e-02 1.417 0 0
SARS-CoV-1 Infection R-HSA-9678108 3.827237e-02 1.417 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 3.856825e-02 1.414 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 3.956014e-02 1.403 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 3.956014e-02 1.403 0 0
Leading Strand Synthesis R-HSA-69109 3.956014e-02 1.403 0 0
Polymerase switching R-HSA-69091 3.956014e-02 1.403 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 3.956014e-02 1.403 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 4.410162e-02 1.356 0 0
Erythropoietin activates RAS R-HSA-9027284 5.372410e-02 1.270 0 0
Dual Incision in GG-NER R-HSA-5696400 4.712761e-02 1.327 0 0
Integrin signaling R-HSA-354192 4.170655e-02 1.380 0 0
Translesion synthesis by REV1 R-HSA-110312 5.372410e-02 1.270 0 0
GPVI-mediated activation cascade R-HSA-114604 5.287728e-02 1.277 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 4.996183e-02 1.301 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 5.461696e-02 1.263 0 0
Activation of ATR in response to replication stress R-HSA-176187 4.170655e-02 1.380 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 4.882584e-02 1.311 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 5.372410e-02 1.270 0 0
S Phase R-HSA-69242 4.600233e-02 1.337 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 5.372410e-02 1.270 0 0
Cilium Assembly R-HSA-5617833 5.454952e-02 1.263 0 0
Selective autophagy R-HSA-9663891 4.287798e-02 1.368 0 0
PIP3 activates AKT signaling R-HSA-1257604 4.706424e-02 1.327 0 0
G-protein beta:gamma signalling R-HSA-397795 4.170655e-02 1.380 0 0
Glucose metabolism R-HSA-70326 4.505336e-02 1.346 0 0
Hemostasis R-HSA-109582 4.500082e-02 1.347 0 0
Potential therapeutics for SARS R-HSA-9679191 4.846258e-02 1.315 0 0
Extracellular matrix organization R-HSA-1474244 4.475099e-02 1.349 0 0
Post NMDA receptor activation events R-HSA-438064 4.133806e-02 1.384 0 0
Cell-extracellular matrix interactions R-HSA-446353 5.372410e-02 1.270 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 5.070328e-02 1.295 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 5.682541e-02 1.245 0 0
Defective SLC26A2 causes chondrodysplasias R-HSA-3560792 5.682541e-02 1.245 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 5.682541e-02 1.245 0 0
Breakdown of the nuclear lamina R-HSA-352238 5.682541e-02 1.245 0 0
Translesion synthesis by POLI R-HSA-5656121 5.878796e-02 1.231 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 5.878796e-02 1.231 0 0
mRNA Splicing - Major Pathway R-HSA-72163 5.953745e-02 1.225 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 6.210079e-02 1.207 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 6.295581e-02 1.201 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 6.325287e-02 1.199 0 0
Translesion synthesis by POLK R-HSA-5655862 6.400926e-02 1.194 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 6.533069e-02 1.185 0 0
Interleukin-2 family signaling R-HSA-451927 6.533069e-02 1.185 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 6.537395e-02 1.185 0 0
FOXO-mediated transcription R-HSA-9614085 6.601941e-02 1.180 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 6.863636e-02 1.163 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 6.863636e-02 1.163 0 0
FLT3 Signaling R-HSA-9607240 6.863636e-02 1.163 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 6.938006e-02 1.159 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 6.938006e-02 1.159 0 0
Uptake and function of anthrax toxins R-HSA-5210891 6.938006e-02 1.159 0 0
Specification of primordial germ cells R-HSA-9827857 6.938006e-02 1.159 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 7.291452e-02 1.137 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 7.489268e-02 1.126 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 7.504258e-02 1.125 0 0
Glycogen storage disease type IV (GBE1) R-HSA-3878781 7.504258e-02 1.125 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 7.504258e-02 1.125 0 0
MTOR signalling R-HSA-165159 7.547003e-02 1.122 0 0
Switching of origins to a post-replicative state R-HSA-69052 7.552234e-02 1.122 0 0
Response of endothelial cells to shear stress R-HSA-9860931 7.646021e-02 1.117 0 0
PLC-gamma1 signalling R-HSA-167021 9.290900e-02 1.032 0 0
Signalling to STAT3 R-HSA-198745 9.290900e-02 1.032 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 1.104314e-01 0.957 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 1.104314e-01 0.957 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 8.631387e-02 1.064 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 9.220825e-02 1.035 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 9.220825e-02 1.035 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 9.821606e-02 1.008 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 1.043308e-01 0.982 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.105460e-01 0.956 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 8.999030e-02 1.046 0 0
Lagging Strand Synthesis R-HSA-69186 9.220825e-02 1.035 0 0
DNA Damage Bypass R-HSA-73893 1.015836e-01 0.993 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 1.071846e-01 0.970 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 8.625698e-02 1.064 0 0
Translesion Synthesis by POLH R-HSA-110320 8.053968e-02 1.094 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 9.821606e-02 1.008 0 0
Co-inhibition by CTLA4 R-HSA-389513 8.631387e-02 1.064 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 9.821606e-02 1.008 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.128846e-02 1.040 0 0
Syndecan interactions R-HSA-3000170 1.105460e-01 0.956 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 1.104314e-01 0.957 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 1.105460e-01 0.956 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 8.626866e-02 1.064 0 0
Clathrin-mediated endocytosis R-HSA-8856828 9.759048e-02 1.011 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 8.053968e-02 1.094 0 0
Co-stimulation by CD28 R-HSA-389356 9.765506e-02 1.010 0 0
Gap junction trafficking R-HSA-190828 8.259158e-02 1.083 0 0
NADE modulates death signalling R-HSA-205025 1.104314e-01 0.957 0 0
Degradation of CDH1 R-HSA-9766229 1.015836e-01 0.993 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 1.178371e-01 0.929 0 0
Gap junction trafficking and regulation R-HSA-157858 1.015836e-01 0.993 0 0
Signaling by NTRKs R-HSA-166520 1.085940e-01 0.964 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 1.043308e-01 0.982 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 8.625698e-02 1.064 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 1.104314e-01 0.957 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.105460e-01 0.956 0 0
Sensory processing of sound R-HSA-9659379 9.213216e-02 1.036 0 0
Metabolism of RNA R-HSA-8953854 1.157784e-01 0.936 0 0
The NLRP3 inflammasome R-HSA-844456 8.053968e-02 1.094 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.003116e-01 0.999 0 0
Vesicle-mediated transport R-HSA-5653656 9.073043e-02 1.042 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.178371e-01 0.929 0 0
Signal transduction by L1 R-HSA-445144 8.631387e-02 1.064 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 8.631387e-02 1.064 0 0
Mitotic Anaphase R-HSA-68882 9.367187e-02 1.028 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 9.536730e-02 1.021 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.043308e-01 0.982 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.105460e-01 0.956 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.103211e-01 0.957 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 8.053968e-02 1.094 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.168557e-01 0.932 0 0
Neurodegenerative Diseases R-HSA-8863678 1.168557e-01 0.932 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 9.505686e-02 1.022 0 0
Meiotic synapsis R-HSA-1221632 1.179051e-01 0.928 0 0
Regulation of PTEN stability and activity R-HSA-8948751 1.179051e-01 0.928 0 0
DNA Replication R-HSA-69306 1.202077e-01 0.920 0 0
Death Receptor Signaling R-HSA-73887 1.226020e-01 0.912 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 1.232539e-01 0.909 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.232539e-01 0.909 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.232539e-01 0.909 0 0
NGF-independant TRKA activation R-HSA-187024 1.444704e-01 0.840 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.444704e-01 0.840 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 1.444704e-01 0.840 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 1.444704e-01 0.840 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 1.444704e-01 0.840 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 1.444704e-01 0.840 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 1.444704e-01 0.840 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 1.444704e-01 0.840 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 1.609998e-01 0.793 0 0
Erythropoietin activates STAT5 R-HSA-9027283 1.609998e-01 0.793 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.772108e-01 0.752 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.772108e-01 0.752 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 1.772108e-01 0.752 0 0
DAG1 core M1 glycosylations R-HSA-8932506 1.772108e-01 0.752 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.772108e-01 0.752 0 0
DAG1 core M2 glycosylations R-HSA-8932504 1.931096e-01 0.714 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 1.931096e-01 0.714 0 0
MET receptor recycling R-HSA-8875656 1.931096e-01 0.714 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.931096e-01 0.714 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.931096e-01 0.714 0 0
Interleukin-21 signaling R-HSA-9020958 2.087022e-01 0.680 0 0
Lipophagy R-HSA-9613354 2.087022e-01 0.680 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 2.087022e-01 0.680 0 0
ALK mutants bind TKIs R-HSA-9700645 2.087022e-01 0.680 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 2.239944e-01 0.650 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 2.239944e-01 0.650 0 0
Folding of actin by CCT/TriC R-HSA-390450 2.239944e-01 0.650 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 2.389920e-01 0.622 0 0
DAG1 core M3 glycosylations R-HSA-8932505 2.389920e-01 0.622 0 0
Signaling by EGFR in Cancer R-HSA-1643713 1.297348e-01 0.887 0 0
Signaling by Erythropoietin R-HSA-9006335 1.496194e-01 0.825 0 0
Late endosomal microautophagy R-HSA-9615710 1.496194e-01 0.825 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.496194e-01 0.825 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.631925e-01 0.787 0 0
Striated Muscle Contraction R-HSA-390522 1.839316e-01 0.735 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 1.909282e-01 0.719 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 1.307419e-01 0.884 0 0
Dual incision in TC-NER R-HSA-6782135 1.395608e-01 0.855 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.485742e-01 0.828 0 0
Termination of translesion DNA synthesis R-HSA-5656169 1.496194e-01 0.825 0 0
Activation of the pre-replicative complex R-HSA-68962 1.563776e-01 0.806 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 2.406687e-01 0.619 0 0
Nucleotide Excision Repair R-HSA-5696398 1.963583e-01 0.707 0 0
DAP12 signaling R-HSA-2424491 1.563776e-01 0.806 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 2.211650e-01 0.655 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.276163e-01 0.894 0 0
Regulation of CDH11 function R-HSA-9762292 2.239944e-01 0.650 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.839316e-01 0.735 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.123410e-01 0.673 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.121114e-01 0.673 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 1.909282e-01 0.719 0 0
Binding and entry of HIV virion R-HSA-173107 2.239944e-01 0.650 0 0
Transferrin endocytosis and recycling R-HSA-917977 1.979596e-01 0.703 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 2.478413e-01 0.606 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 1.496194e-01 0.825 0 0
PTK6 Expression R-HSA-8849473 1.772108e-01 0.752 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.769740e-01 0.752 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 1.444704e-01 0.840 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.406687e-01 0.619 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.814788e-01 0.741 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 1.438257e-01 0.842 0 0
Generation of second messenger molecules R-HSA-202433 2.335063e-01 0.632 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 1.943689e-01 0.711 0 0
Parasite infection R-HSA-9664407 1.943689e-01 0.711 0 0
Leishmania phagocytosis R-HSA-9664417 1.943689e-01 0.711 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 1.444704e-01 0.840 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 2.239944e-01 0.650 0 0
vRNP Assembly R-HSA-192905 2.389920e-01 0.622 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.362929e-01 0.866 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 1.631925e-01 0.787 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 1.909282e-01 0.719 0 0
DNA Replication Pre-Initiation R-HSA-69002 2.123410e-01 0.673 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.337639e-01 0.874 0 0
Ribosome-associated quality control R-HSA-9948299 1.877141e-01 0.727 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.087022e-01 0.680 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 1.961374e-01 0.707 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 1.700595e-01 0.769 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 2.192242e-01 0.659 0 0
Integrin cell surface interactions R-HSA-216083 2.364776e-01 0.626 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 1.324113e-01 0.878 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.438257e-01 0.842 0 0
VLDL clearance R-HSA-8964046 1.772108e-01 0.752 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 2.239944e-01 0.650 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 1.496194e-01 0.825 1 1
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 1.700595e-01 0.769 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.909282e-01 0.719 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 1.979596e-01 0.703 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 1.979596e-01 0.703 0 0
Degradation of CRY and PER proteins R-HSA-9932298 2.478413e-01 0.606 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 2.478413e-01 0.606 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 1.297348e-01 0.887 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.263570e-01 0.645 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 2.087022e-01 0.680 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 1.264093e-01 0.898 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 1.979596e-01 0.703 0 0
Degradation of DVL R-HSA-4641258 2.121114e-01 0.673 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 1.320344e-01 0.879 0 0
Autophagy R-HSA-9612973 1.274606e-01 0.895 0 0
Iron uptake and transport R-HSA-917937 2.211650e-01 0.655 0 0
UCH proteinases R-HSA-5689603 2.262472e-01 0.645 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 1.276163e-01 0.894 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.772108e-01 0.752 0 0
Bicarbonate transporters R-HSA-425381 2.389920e-01 0.622 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 2.050219e-01 0.688 0 0
Degradation of AXIN R-HSA-4641257 2.121114e-01 0.673 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 2.121114e-01 0.673 0 0
Ion homeostasis R-HSA-5578775 1.307419e-01 0.884 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.807704e-01 0.743 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.351262e-01 0.869 0 0
Effects of PIP2 hydrolysis R-HSA-114508 1.839316e-01 0.735 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 2.478413e-01 0.606 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.769740e-01 0.752 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.909282e-01 0.719 0 0
Interferon Signaling R-HSA-913531 1.695636e-01 0.771 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 1.769404e-01 0.752 0 0
Reproduction R-HSA-1474165 1.588675e-01 0.799 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.444704e-01 0.840 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 1.444704e-01 0.840 0 0
CHL1 interactions R-HSA-447041 1.772108e-01 0.752 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 2.087022e-01 0.680 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 2.389920e-01 0.622 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 1.563776e-01 0.806 0 0
Vpu mediated degradation of CD4 R-HSA-180534 1.839316e-01 0.735 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 1.909282e-01 0.719 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 1.909282e-01 0.719 0 0
Regulation of Apoptosis R-HSA-169911 1.979596e-01 0.703 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 2.478413e-01 0.606 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 2.478413e-01 0.606 0 0
Organelle biogenesis and maintenance R-HSA-1852241 2.222765e-01 0.653 0 0
TCR signaling R-HSA-202403 2.163930e-01 0.665 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.706315e-01 0.768 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.364776e-01 0.626 0 0
ESR-mediated signaling R-HSA-8939211 2.383068e-01 0.623 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.979596e-01 0.703 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 2.406687e-01 0.619 0 0
Macroautophagy R-HSA-1632852 1.977272e-01 0.704 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.467869e-01 0.608 0 0
Neurofascin interactions R-HSA-447043 1.609998e-01 0.793 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 2.389920e-01 0.622 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.362929e-01 0.866 0 0
Inflammasomes R-HSA-622312 1.429229e-01 0.845 0 0
Ovarian tumor domain proteases R-HSA-5689896 2.121114e-01 0.673 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 2.263570e-01 0.645 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 2.263570e-01 0.645 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 2.043032e-01 0.690 0 0
Signaling by ALK in cancer R-HSA-9700206 2.043032e-01 0.690 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.693660e-01 0.771 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 2.406687e-01 0.619 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 1.811444e-01 0.742 0 0
Transmission across Chemical Synapses R-HSA-112315 2.295101e-01 0.639 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.307419e-01 0.884 0 0
Innate Immune System R-HSA-168249 1.463436e-01 0.835 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 1.307419e-01 0.884 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.258991e-01 0.900 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 2.335063e-01 0.632 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 2.406687e-01 0.619 0 0
Interleukin-2 signaling R-HSA-9020558 2.389920e-01 0.622 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.060661e-01 0.686 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.961374e-01 0.707 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 2.192242e-01 0.659 0 0
Gene expression (Transcription) R-HSA-74160 2.081010e-01 0.682 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.362929e-01 0.866 0 0
PCP/CE pathway R-HSA-4086400 2.364776e-01 0.626 0 0
G0 and Early G1 R-HSA-1538133 1.700595e-01 0.769 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 1.839316e-01 0.735 0 0
G1/S-Specific Transcription R-HSA-69205 2.050219e-01 0.688 0 0
Viral Infection Pathways R-HSA-9824446 2.419764e-01 0.616 0 0
Stabilization of p53 R-HSA-69541 2.263570e-01 0.645 0 0
Dissolution of Fibrin Clot R-HSA-75205 2.389920e-01 0.622 0 0
Neuronal System R-HSA-112316 2.493323e-01 0.603 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.537006e-01 0.596 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 2.537006e-01 0.596 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 2.537006e-01 0.596 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 2.575948e-01 0.589 0 0
Signaling by SCF-KIT R-HSA-1433557 2.622044e-01 0.581 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 2.622044e-01 0.581 0 0
Translation R-HSA-72766 2.656392e-01 0.576 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 2.673661e-01 0.573 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 2.681258e-01 0.572 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 2.681258e-01 0.572 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.681258e-01 0.572 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.681258e-01 0.572 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 2.681258e-01 0.572 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 2.681258e-01 0.572 0 0
Scavenging by Class F Receptors R-HSA-3000484 2.681258e-01 0.572 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.681258e-01 0.572 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.681258e-01 0.572 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.681258e-01 0.572 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.681258e-01 0.572 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 2.681258e-01 0.572 0 0
GRB2 events in EGFR signaling R-HSA-179812 2.681258e-01 0.572 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 2.681258e-01 0.572 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 2.681258e-01 0.572 0 0
OAS antiviral response R-HSA-8983711 2.681258e-01 0.572 0 0
DAP12 interactions R-HSA-2172127 2.693892e-01 0.570 0 0
Proteasome assembly R-HSA-9907900 2.693892e-01 0.570 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 2.693892e-01 0.570 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 2.707306e-01 0.567 0 0
Meiosis R-HSA-1500620 2.728376e-01 0.564 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.728376e-01 0.564 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 2.765725e-01 0.558 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 2.765725e-01 0.558 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 2.765725e-01 0.558 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 2.765725e-01 0.558 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 2.765725e-01 0.558 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 2.765725e-01 0.558 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 2.780853e-01 0.556 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 2.780853e-01 0.556 0 0
Infectious disease R-HSA-5663205 2.786788e-01 0.555 0 0
Signaling by Interleukins R-HSA-449147 2.815518e-01 0.550 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 2.822731e-01 0.549 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 2.822731e-01 0.549 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 2.822731e-01 0.549 0 0
Formation of axial mesoderm R-HSA-9796292 2.822731e-01 0.549 0 0
Maturation of nucleoprotein R-HSA-9683610 2.822731e-01 0.549 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.822731e-01 0.549 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 2.822731e-01 0.549 0 0
RNA Polymerase II Transcription R-HSA-73857 2.823404e-01 0.549 0 0
Separation of Sister Chromatids R-HSA-2467813 2.833289e-01 0.548 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 2.837517e-01 0.547 0 0
Regulation of TNFR1 signaling R-HSA-5357905 2.837517e-01 0.547 0 0
Diseases of DNA repair R-HSA-9675135 2.837517e-01 0.547 0 0
Regulation of pyruvate metabolism R-HSA-9861718 2.837517e-01 0.547 1 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 2.837517e-01 0.547 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 2.837517e-01 0.547 0 0
Generic Transcription Pathway R-HSA-212436 2.892907e-01 0.539 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 2.909244e-01 0.536 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.946720e-01 0.531 0 0
Removal of the Flap Intermediate R-HSA-69166 2.961477e-01 0.528 0 0
Retrograde neurotrophin signalling R-HSA-177504 2.961477e-01 0.528 0 0
Regulation of KIT signaling R-HSA-1433559 2.961477e-01 0.528 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 2.961477e-01 0.528 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 2.961477e-01 0.528 0 0
HDL assembly R-HSA-8963896 2.961477e-01 0.528 0 0
Signal regulatory protein family interactions R-HSA-391160 2.961477e-01 0.528 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 2.961477e-01 0.528 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 2.980880e-01 0.526 0 0
Chemokine receptors bind chemokines R-HSA-380108 3.052403e-01 0.515 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 3.052403e-01 0.515 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 3.052403e-01 0.515 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 3.096020e-01 0.509 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 3.097355e-01 0.509 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 3.097355e-01 0.509 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 3.097550e-01 0.509 0 0
SHC1 events in EGFR signaling R-HSA-180336 3.097550e-01 0.509 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 3.097550e-01 0.509 0 0
Processive synthesis on the lagging strand R-HSA-69183 3.097550e-01 0.509 0 0
Synthesis of 12-eicosatetraenoic acid derivatives R-HSA-2142712 3.097550e-01 0.509 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 3.097550e-01 0.509 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 3.097550e-01 0.509 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 3.097550e-01 0.509 0 0
Transport and metabolism of PAPS R-HSA-174362 3.097550e-01 0.509 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 3.097550e-01 0.509 0 0
Protein methylation R-HSA-8876725 3.097550e-01 0.509 0 0
Regulation of RAS by GAPs R-HSA-5658442 3.123790e-01 0.505 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 3.150274e-01 0.502 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 3.195019e-01 0.496 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 3.195019e-01 0.496 0 0
Hedgehog ligand biogenesis R-HSA-5358346 3.195019e-01 0.496 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 3.231001e-01 0.491 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 3.231001e-01 0.491 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 3.231001e-01 0.491 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 3.231001e-01 0.491 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 3.231001e-01 0.491 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 3.266072e-01 0.486 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 3.266072e-01 0.486 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 3.266072e-01 0.486 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 3.271090e-01 0.485 0 0
Circadian clock R-HSA-9909396 3.271090e-01 0.485 0 0
Disease R-HSA-1643685 3.321696e-01 0.479 0 0
Signaling by Nuclear Receptors R-HSA-9006931 3.327947e-01 0.478 1 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 3.336927e-01 0.477 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 3.336927e-01 0.477 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 3.361879e-01 0.473 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 3.361879e-01 0.473 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 3.361879e-01 0.473 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 3.361879e-01 0.473 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 3.362042e-01 0.473 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 3.407566e-01 0.468 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 3.407566e-01 0.468 0 0
COPI-mediated anterograde transport R-HSA-6807878 3.467841e-01 0.460 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 3.467841e-01 0.460 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 3.477970e-01 0.459 0 0
Signaling by NOTCH3 R-HSA-9012852 3.477970e-01 0.459 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 3.490235e-01 0.457 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 3.490235e-01 0.457 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 3.490235e-01 0.457 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 3.490235e-01 0.457 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 3.490235e-01 0.457 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 3.490235e-01 0.457 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 3.490235e-01 0.457 0 0
Synthesis of 15-eicosatetraenoic acid derivatives R-HSA-2142770 3.490235e-01 0.457 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 3.490235e-01 0.457 0 0
Glycogen storage diseases R-HSA-3229121 3.490235e-01 0.457 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 3.490235e-01 0.457 0 0
Estrogen-dependent gene expression R-HSA-9018519 3.490339e-01 0.457 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 3.520685e-01 0.453 0 0
Epigenetic regulation of gene expression R-HSA-212165 3.544494e-01 0.450 0 0
TNF signaling R-HSA-75893 3.548124e-01 0.450 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 3.548124e-01 0.450 0 0
Ephrin signaling R-HSA-3928664 3.616116e-01 0.442 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 3.616116e-01 0.442 0 0
GAB1 signalosome R-HSA-180292 3.616116e-01 0.442 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 3.616116e-01 0.442 0 0
Presynaptic function of Kainate receptors R-HSA-500657 3.616116e-01 0.442 0 0
Mismatch Repair R-HSA-5358508 3.616116e-01 0.442 0 0
Platelet sensitization by LDL R-HSA-432142 3.616116e-01 0.442 0 0
Transport of connexons to the plasma membrane R-HSA-190872 3.616116e-01 0.442 0 0
Synaptic adhesion-like molecules R-HSA-8849932 3.616116e-01 0.442 0 0
Tie2 Signaling R-HSA-210993 3.616116e-01 0.442 0 0
Dectin-2 family R-HSA-5621480 3.618009e-01 0.442 0 0
PTEN Regulation R-HSA-6807070 3.622026e-01 0.441 0 0
Hedgehog 'off' state R-HSA-5610787 3.678891e-01 0.434 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 3.687611e-01 0.433 0 0
Leishmania infection R-HSA-9658195 3.725169e-01 0.429 0 0
Parasitic Infection Pathways R-HSA-9824443 3.725169e-01 0.429 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 3.739571e-01 0.427 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 3.739571e-01 0.427 0 0
Germ layer formation at gastrulation R-HSA-9754189 3.739571e-01 0.427 0 0
Specification of the neural plate border R-HSA-9834899 3.739571e-01 0.427 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 3.739571e-01 0.427 0 0
Other interleukin signaling R-HSA-449836 3.739571e-01 0.427 0 0
Maturation of nucleoprotein R-HSA-9694631 3.739571e-01 0.427 0 0
STING mediated induction of host immune responses R-HSA-1834941 3.739571e-01 0.427 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 3.739571e-01 0.427 0 0
Immune System R-HSA-168256 3.750972e-01 0.426 0 0
Extension of Telomeres R-HSA-180786 3.756913e-01 0.425 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 3.783156e-01 0.422 0 0
Metabolism of polyamines R-HSA-351202 3.825903e-01 0.417 0 0
Signaling by Retinoic Acid R-HSA-5362517 3.825903e-01 0.417 1 1
Cell surface interactions at the vascular wall R-HSA-202733 3.860457e-01 0.413 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 3.860646e-01 0.413 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 3.860646e-01 0.413 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 3.860646e-01 0.413 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 3.860646e-01 0.413 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 3.860646e-01 0.413 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 3.860646e-01 0.413 0 0
Creatine metabolism R-HSA-71288 3.860646e-01 0.413 0 0
Nephrin family interactions R-HSA-373753 3.860646e-01 0.413 0 0
Glycogen synthesis R-HSA-3322077 3.860646e-01 0.413 0 0
Protein hydroxylation R-HSA-9629569 3.860646e-01 0.413 0 0
FCERI mediated NF-kB activation R-HSA-2871837 3.885009e-01 0.411 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 3.894565e-01 0.410 0 0
Heme signaling R-HSA-9707616 3.962888e-01 0.402 0 0
Signaling by PDGF R-HSA-186797 3.962888e-01 0.402 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 3.962888e-01 0.402 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 3.979387e-01 0.400 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 3.979387e-01 0.400 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 3.979387e-01 0.400 0 0
Signalling to RAS R-HSA-167044 3.979387e-01 0.400 0 0
Early Phase of HIV Life Cycle R-HSA-162594 3.979387e-01 0.400 0 0
Basigin interactions R-HSA-210991 3.979387e-01 0.400 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 4.030858e-01 0.395 0 0
Bacterial Infection Pathways R-HSA-9824439 4.094646e-01 0.388 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 4.095838e-01 0.388 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 4.095838e-01 0.388 0 0
Attachment and Entry R-HSA-9694614 4.095838e-01 0.388 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 4.095838e-01 0.388 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 4.095838e-01 0.388 0 0
Mitochondrial calcium ion transport R-HSA-8949215 4.095838e-01 0.388 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 4.098463e-01 0.387 0 0
Cellular response to hypoxia R-HSA-1234174 4.165693e-01 0.380 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 4.165693e-01 0.380 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 4.210044e-01 0.376 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 4.210044e-01 0.376 0 0
Notch-HLH transcription pathway R-HSA-350054 4.210044e-01 0.376 0 0
Signaling by KIT in disease R-HSA-9669938 4.210044e-01 0.376 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 4.210044e-01 0.376 0 0
LDL clearance R-HSA-8964038 4.210044e-01 0.376 0 0
Signaling by WNT R-HSA-195721 4.262371e-01 0.370 0 0
DNA Double-Strand Break Repair R-HSA-5693532 4.276432e-01 0.369 0 0
Interleukin receptor SHC signaling R-HSA-912526 4.322048e-01 0.364 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 4.322048e-01 0.364 0 0
Growth hormone receptor signaling R-HSA-982772 4.322048e-01 0.364 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 4.353903e-01 0.361 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 4.353903e-01 0.361 0 0
FCERI mediated MAPK activation R-HSA-2871796 4.353903e-01 0.361 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 4.404824e-01 0.356 0 0
Deadenylation of mRNA R-HSA-429947 4.431892e-01 0.353 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 4.431892e-01 0.353 0 0
Complex III assembly R-HSA-9865881 4.431892e-01 0.353 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 4.431892e-01 0.353 0 0
Plasma lipoprotein assembly R-HSA-8963898 4.431892e-01 0.353 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 4.455570e-01 0.351 0 0
Deubiquitination R-HSA-5688426 4.478922e-01 0.349 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 4.495850e-01 0.347 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 4.495850e-01 0.347 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 4.495850e-01 0.347 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 4.502092e-01 0.347 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 4.539617e-01 0.343 0 0
Tight junction interactions R-HSA-420029 4.539617e-01 0.343 0 0
HDMs demethylate histones R-HSA-3214842 4.539617e-01 0.343 0 0
Formation of the nephric duct R-HSA-9830364 4.539617e-01 0.343 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 4.539617e-01 0.343 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 4.560619e-01 0.341 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 4.560619e-01 0.341 0 0
ECM proteoglycans R-HSA-3000178 4.560619e-01 0.341 0 0
Regulation of mitotic cell cycle R-HSA-453276 4.560619e-01 0.341 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 4.560619e-01 0.341 0 0
Hedgehog 'on' state R-HSA-5632684 4.560619e-01 0.341 0 0
Regulation of TP53 Activity R-HSA-5633007 4.576429e-01 0.339 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 4.606691e-01 0.337 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 4.624949e-01 0.335 0 0
Myogenesis R-HSA-525793 4.645265e-01 0.333 0 0
Metalloprotease DUBs R-HSA-5689901 4.645265e-01 0.333 0 0
Sphingolipid catabolism R-HSA-9845614 4.645265e-01 0.333 0 0
Ca2+ pathway R-HSA-4086398 4.688831e-01 0.329 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 4.688831e-01 0.329 0 0
Rab regulation of trafficking R-HSA-9007101 4.706455e-01 0.327 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 4.748875e-01 0.323 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 4.748875e-01 0.323 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 4.748875e-01 0.323 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 4.748875e-01 0.323 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 4.748875e-01 0.323 0 0
Homology Directed Repair R-HSA-5693538 4.756026e-01 0.323 0 0
G alpha (q) signalling events R-HSA-416476 4.783740e-01 0.320 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 4.805384e-01 0.318 0 0
Protein ubiquitination R-HSA-8852135 4.815229e-01 0.317 0 0
ISG15 antiviral mechanism R-HSA-1169408 4.815229e-01 0.317 0 0
Insulin receptor recycling R-HSA-77387 4.850487e-01 0.314 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 4.850487e-01 0.314 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 4.850487e-01 0.314 0 0
Interleukin-12 signaling R-HSA-9020591 4.877732e-01 0.312 0 0
Chromosome Maintenance R-HSA-73886 4.903439e-01 0.309 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 4.903439e-01 0.309 0 0
Translation of Structural Proteins R-HSA-9694635 4.939764e-01 0.306 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 4.950139e-01 0.305 0 0
Platelet calcium homeostasis R-HSA-418360 4.950139e-01 0.305 0 0
Regulation of gene expression in beta cells R-HSA-210745 4.950139e-01 0.305 0 0
MHC class II antigen presentation R-HSA-2132295 5.000584e-01 0.301 0 0
RNA Polymerase I Transcription R-HSA-73864 5.001318e-01 0.301 0 0
G alpha (12/13) signalling events R-HSA-416482 5.001318e-01 0.301 0 0
ABC transporter disorders R-HSA-5619084 5.001318e-01 0.301 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 5.047868e-01 0.297 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 5.047868e-01 0.297 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 5.077414e-01 0.294 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 5.118255e-01 0.291 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 5.122980e-01 0.290 0 0
EGFR downregulation R-HSA-182971 5.143711e-01 0.289 0 0
Molecules associated with elastic fibres R-HSA-2129379 5.143711e-01 0.289 0 0
Downstream signal transduction R-HSA-186763 5.143711e-01 0.289 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 5.143711e-01 0.289 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 5.143711e-01 0.289 0 0
Processing of DNA double-strand break ends R-HSA-5693607 5.183077e-01 0.285 0 0
DAG1 glycosylations R-HSA-8931838 5.237706e-01 0.281 0 0
HS-GAG degradation R-HSA-2024096 5.237706e-01 0.281 0 0
Signaling by WNT in cancer R-HSA-4791275 5.237706e-01 0.281 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 5.239844e-01 0.281 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 5.301789e-01 0.276 0 0
Nuclear RNA decay R-HSA-9930044 5.329887e-01 0.273 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 5.329887e-01 0.273 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 5.329887e-01 0.273 0 0
FGFR1 mutant receptor activation R-HSA-1839124 5.329887e-01 0.273 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 5.329887e-01 0.273 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 5.329887e-01 0.273 0 0
Regulation of necroptotic cell death R-HSA-5675482 5.329887e-01 0.273 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 5.329887e-01 0.273 0 0
Cardiogenesis R-HSA-9733709 5.329887e-01 0.273 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 5.360396e-01 0.271 0 0
Resolution of D-Loop Structures R-HSA-5693537 5.420289e-01 0.266 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 5.420289e-01 0.266 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 5.420289e-01 0.266 0 0
rRNA processing R-HSA-72312 5.455520e-01 0.263 0 0
Cardiac conduction R-HSA-5576891 5.471565e-01 0.262 0 0
Amplification of signal from the kinetochores R-HSA-141424 5.476100e-01 0.262 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 5.476100e-01 0.262 0 0
Signaling by NOTCH2 R-HSA-1980145 5.508947e-01 0.259 0 0
RAF activation R-HSA-5673000 5.508947e-01 0.259 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 5.508947e-01 0.259 0 0
eNOS activation R-HSA-203615 5.508947e-01 0.259 0 0
Gap junction assembly R-HSA-190861 5.508947e-01 0.259 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 5.508947e-01 0.259 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 5.533191e-01 0.257 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 5.533191e-01 0.257 0 0
TCF dependent signaling in response to WNT R-HSA-201681 5.556772e-01 0.255 0 0
Chaperonin-mediated protein folding R-HSA-390466 5.589773e-01 0.253 0 0
Pyruvate metabolism R-HSA-70268 5.589773e-01 0.253 1 0
Interleukin-12 family signaling R-HSA-447115 5.589773e-01 0.253 0 0
Diseases of glycosylation R-HSA-3781865 5.595598e-01 0.252 0 0
Peptide chain elongation R-HSA-156902 5.645844e-01 0.248 0 0
Diseases of programmed cell death R-HSA-9645723 5.645844e-01 0.248 0 0
Peptide ligand-binding receptors R-HSA-375276 5.672699e-01 0.246 0 0
HS-GAG biosynthesis R-HSA-2022928 5.681162e-01 0.246 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 5.681162e-01 0.246 0 0
RET signaling R-HSA-8853659 5.681162e-01 0.246 0 0
Regulation of TP53 Degradation R-HSA-6804757 5.681162e-01 0.246 0 0
ER-Phagosome pathway R-HSA-1236974 5.701403e-01 0.244 0 0
Base Excision Repair R-HSA-73884 5.756448e-01 0.240 0 0
Neurotransmitter release cycle R-HSA-112310 5.756448e-01 0.240 0 0
Downstream TCR signaling R-HSA-202424 5.756448e-01 0.240 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 5.764785e-01 0.239 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 5.764785e-01 0.239 0 0
Signaling by Hedgehog R-HSA-5358351 5.829135e-01 0.234 0 0
MET promotes cell motility R-HSA-8875878 5.846794e-01 0.233 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 5.846794e-01 0.233 0 0
Elastic fibre formation R-HSA-1566948 5.846794e-01 0.233 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 5.846794e-01 0.233 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 5.899467e-01 0.229 0 0
Eukaryotic Translation Elongation R-HSA-156842 5.918491e-01 0.228 0 0
Protein folding R-HSA-391251 5.918491e-01 0.228 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 5.918491e-01 0.228 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 5.918491e-01 0.228 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 5.927220e-01 0.227 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 5.927220e-01 0.227 0 0
Plasma lipoprotein clearance R-HSA-8964043 5.927220e-01 0.227 0 0
Pentose phosphate pathway R-HSA-71336 5.927220e-01 0.227 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 5.927220e-01 0.227 0 0
FCGR activation R-HSA-2029481 5.971474e-01 0.224 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 6.006093e-01 0.221 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 6.006093e-01 0.221 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 6.006093e-01 0.221 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 6.006093e-01 0.221 0 0
Glycogen metabolism R-HSA-8982491 6.006093e-01 0.221 0 0
Chromatin organization R-HSA-4839726 6.032007e-01 0.220 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 6.043346e-01 0.219 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 6.075890e-01 0.216 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 6.083444e-01 0.216 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 6.083444e-01 0.216 0 0
Maturation of spike protein R-HSA-9694548 6.083444e-01 0.216 0 0
Eukaryotic Translation Termination R-HSA-72764 6.127325e-01 0.213 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 6.127325e-01 0.213 0 0
Signaling by FGFR1 in disease R-HSA-5655302 6.159301e-01 0.210 0 0
Intra-Golgi traffic R-HSA-6811438 6.159301e-01 0.210 0 0
Negative regulation of MAPK pathway R-HSA-5675221 6.159301e-01 0.210 0 0
Translation of Structural Proteins R-HSA-9683701 6.159301e-01 0.210 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 6.178244e-01 0.209 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 6.178244e-01 0.209 0 0
Co-inhibition by PD-1 R-HSA-389948 6.190761e-01 0.208 0 0
Telomere Maintenance R-HSA-157579 6.228649e-01 0.206 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 6.233694e-01 0.205 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 6.233694e-01 0.205 0 0
ER to Golgi Anterograde Transport R-HSA-199977 6.250186e-01 0.204 0 0
Post-translational protein phosphorylation R-HSA-8957275 6.278539e-01 0.202 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 6.306650e-01 0.200 0 0
HATs acetylate histones R-HSA-3214847 6.327917e-01 0.199 0 0
Mitotic Spindle Checkpoint R-HSA-69618 6.376783e-01 0.195 0 0
ABC-family proteins mediated transport R-HSA-382556 6.376783e-01 0.195 0 0
Netrin-1 signaling R-HSA-373752 6.378197e-01 0.195 0 0
Surfactant metabolism R-HSA-5683826 6.378197e-01 0.195 0 0
Cyclin D associated events in G1 R-HSA-69231 6.378197e-01 0.195 0 0
G1 Phase R-HSA-69236 6.378197e-01 0.195 0 0
Selenocysteine synthesis R-HSA-2408557 6.425139e-01 0.192 0 0
Interleukin-1 signaling R-HSA-9020702 6.425139e-01 0.192 0 0
Nucleosome assembly R-HSA-774815 6.448363e-01 0.191 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 6.448363e-01 0.191 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 6.472986e-01 0.189 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 6.517174e-01 0.186 0 0
Viral mRNA Translation R-HSA-192823 6.520325e-01 0.186 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 6.527140e-01 0.185 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 6.565492e-01 0.183 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 6.567158e-01 0.183 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 6.567158e-01 0.183 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 6.584655e-01 0.181 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 6.584655e-01 0.181 0 0
RSV-host interactions R-HSA-9833110 6.613488e-01 0.180 0 0
Intraflagellar transport R-HSA-5620924 6.650833e-01 0.177 0 0
NGF-stimulated transcription R-HSA-9031628 6.650833e-01 0.177 0 0
Cellular response to starvation R-HSA-9711097 6.678723e-01 0.175 0 0
Platelet homeostasis R-HSA-418346 6.704643e-01 0.174 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 6.715733e-01 0.173 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 6.749473e-01 0.171 0 0
Signaling by TGFB family members R-HSA-9006936 6.752688e-01 0.171 0 0
Antigen processing-Cross presentation R-HSA-1236975 6.793807e-01 0.168 0 0
Meiotic recombination R-HSA-912446 6.841796e-01 0.165 0 0
Selenoamino acid metabolism R-HSA-2408522 6.896971e-01 0.161 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 6.903007e-01 0.161 0 0
Neurexins and neuroligins R-HSA-6794361 6.903007e-01 0.161 0 0
Adaptive Immune System R-HSA-1280218 6.910504e-01 0.160 0 0
Neddylation R-HSA-8951664 6.922348e-01 0.160 0 0
Amino acids regulate mTORC1 R-HSA-9639288 6.963035e-01 0.157 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 6.963035e-01 0.157 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 6.963035e-01 0.157 0 0
Nucleotide biosynthesis R-HSA-8956320 6.963035e-01 0.157 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 7.073953e-01 0.150 0 0
HDACs deacetylate histones R-HSA-3214815 7.079634e-01 0.150 0 0
G alpha (z) signalling events R-HSA-418597 7.079634e-01 0.150 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 7.090479e-01 0.149 0 0
Signaling by EGFR R-HSA-177929 7.136249e-01 0.147 0 0
NRAGE signals death through JNK R-HSA-193648 7.136249e-01 0.147 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 7.136249e-01 0.147 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 7.246218e-01 0.140 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 7.299613e-01 0.137 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 7.299613e-01 0.137 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 7.299613e-01 0.137 0 0
Regulation of beta-cell development R-HSA-186712 7.299613e-01 0.137 0 0
Chromatin modifying enzymes R-HSA-3247509 7.305147e-01 0.136 0 0
Kinesins R-HSA-983189 7.351977e-01 0.134 0 0
Regulation of PTEN gene transcription R-HSA-8943724 7.351977e-01 0.134 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 7.351977e-01 0.134 0 0
PLC beta mediated events R-HSA-112043 7.403328e-01 0.131 0 0
Influenza Infection R-HSA-168255 7.426023e-01 0.129 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 7.474262e-01 0.126 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 7.503071e-01 0.125 0 0
Formation of the cornified envelope R-HSA-6809371 7.510153e-01 0.124 0 0
Host Interactions of HIV factors R-HSA-162909 7.510153e-01 0.124 0 0
DNA Repair R-HSA-73894 7.517898e-01 0.124 0 0
CD22 mediated BCR regulation R-HSA-5690714 7.551501e-01 0.122 0 0
Ion transport by P-type ATPases R-HSA-936837 7.551501e-01 0.122 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 7.615210e-01 0.118 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 7.645570e-01 0.117 0 0
Disorders of transmembrane transporters R-HSA-5619115 7.651311e-01 0.116 0 0
DNA Double Strand Break Response R-HSA-5693606 7.691245e-01 0.114 0 0
G-protein mediated events R-HSA-112040 7.691245e-01 0.114 0 0
Kidney development R-HSA-9830369 7.691245e-01 0.114 0 0
Ion channel transport R-HSA-983712 7.718737e-01 0.112 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 7.736037e-01 0.111 0 0
Regulated Necrosis R-HSA-5218859 7.736037e-01 0.111 0 0
Adipogenesis R-HSA-9843745 7.813864e-01 0.107 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 7.823037e-01 0.107 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 7.865280e-01 0.104 0 0
Retinoid metabolism and transport R-HSA-975634 7.865280e-01 0.104 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 7.865280e-01 0.104 0 0
Metabolism of cofactors R-HSA-8978934 7.865280e-01 0.104 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 7.906705e-01 0.102 0 0
HCMV Early Events R-HSA-9609690 7.907065e-01 0.102 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 7.947329e-01 0.100 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 7.987167e-01 0.098 0 0
Signaling by FGFR in disease R-HSA-1226099 7.987167e-01 0.098 0 0
ROS and RNS production in phagocytes R-HSA-1222556 7.987167e-01 0.098 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 8.058072e-01 0.094 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 8.064545e-01 0.093 0 0
SLC-mediated transport of organic anions R-HSA-9955298 8.138958e-01 0.089 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 8.175088e-01 0.088 0 0
Signaling by MET R-HSA-6806834 8.210519e-01 0.086 0 0
Amyloid fiber formation R-HSA-977225 8.245264e-01 0.084 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 8.245264e-01 0.084 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 8.245264e-01 0.084 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.312749e-01 0.080 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.411676e-01 0.075 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 8.440057e-01 0.074 0 0
Interleukin-1 family signaling R-HSA-446652 8.446838e-01 0.073 0 0
GPCR downstream signalling R-HSA-388396 8.528620e-01 0.069 0 0
HIV Infection R-HSA-162906 8.610419e-01 0.065 0 0
Signaling by Insulin receptor R-HSA-74752 8.640234e-01 0.063 0 0
Mitochondrial protein degradation R-HSA-9837999 8.692571e-01 0.061 0 0
Collagen formation R-HSA-1474290 8.692571e-01 0.061 0 0
Diseases of metabolism R-HSA-5668914 8.708656e-01 0.060 0 0
SLC transporter disorders R-HSA-5619102 8.765059e-01 0.057 0 0
Metabolism of nucleotides R-HSA-15869 8.766813e-01 0.057 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 8.767335e-01 0.057 0 0
Signaling by GPCR R-HSA-372790 8.778406e-01 0.057 0 0
Regulation of insulin secretion R-HSA-422356 8.814794e-01 0.055 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 8.892035e-01 0.051 0 0
Leishmania parasite growth and survival R-HSA-9664433 8.892035e-01 0.051 0 0
Ub-specific processing proteases R-HSA-5689880 8.892035e-01 0.051 0 0
Opioid Signalling R-HSA-111885 8.946519e-01 0.048 0 0
HCMV Infection R-HSA-9609646 8.979221e-01 0.047 0 0
Cellular Senescence R-HSA-2559583 9.006837e-01 0.045 0 0
Gene Silencing by RNA R-HSA-211000 9.026121e-01 0.044 0 0
Stimuli-sensing channels R-HSA-2672351 9.045067e-01 0.044 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.084251e-01 0.042 0 0
Inositol phosphate metabolism R-HSA-1483249 9.117245e-01 0.040 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.191203e-01 0.037 0 0
Interferon alpha/beta signaling R-HSA-909733 9.199866e-01 0.036 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.199866e-01 0.036 0 0
Mitochondrial biogenesis R-HSA-1592230 9.230714e-01 0.035 0 0
Peptide hormone metabolism R-HSA-2980736 9.230714e-01 0.035 0 0
Keratinization R-HSA-6805567 9.353580e-01 0.029 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 9.355498e-01 0.029 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 9.355498e-01 0.029 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 9.355498e-01 0.029 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.449364e-01 0.025 0 0
Integration of energy metabolism R-HSA-163685 9.500974e-01 0.022 0 0
O-linked glycosylation R-HSA-5173105 9.510703e-01 0.022 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.558712e-01 0.020 0 0
Transport of small molecules R-HSA-382551 9.570092e-01 0.019 0 0
Visual phototransduction R-HSA-2187338 9.606008e-01 0.017 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.628622e-01 0.016 0 0
Arachidonate metabolism R-HSA-2142753 9.642974e-01 0.016 0 0
Protein localization R-HSA-9609507 9.649942e-01 0.015 0 0
PPARA activates gene expression R-HSA-1989781 9.663472e-01 0.015 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.676482e-01 0.014 0 0
HIV Life Cycle R-HSA-162587 9.676482e-01 0.014 0 0
G alpha (i) signalling events R-HSA-418594 9.681402e-01 0.014 0 0
Interferon gamma signaling R-HSA-877300 9.688990e-01 0.014 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.724506e-01 0.012 1 0
Asparagine N-linked glycosylation R-HSA-446203 9.741116e-01 0.011 0 0
G alpha (s) signalling events R-HSA-418555 9.759334e-01 0.011 0 0
Respiratory electron transport R-HSA-611105 9.790389e-01 0.009 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.862069e-01 0.006 0 0
Sphingolipid metabolism R-HSA-428157 9.866929e-01 0.006 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.885317e-01 0.005 0 0
GPCR ligand binding R-HSA-500792 9.926515e-01 0.003 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.955665e-01 0.002 0 0
Metabolism of proteins R-HSA-392499 9.956096e-01 0.002 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.971638e-01 0.001 0 0
Post-translational protein modification R-HSA-597592 9.975719e-01 0.001 0 0
Metabolism of steroids R-HSA-8957322 9.988643e-01 0.000 0 0
Fatty acid metabolism R-HSA-8978868 9.997880e-01 0.000 0 0
Biological oxidations R-HSA-211859 9.999794e-01 0.000 0 0
Sensory Perception R-HSA-9709957 9.999998e-01 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 0.000 1 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways