MAST2

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
Log-Odds: S Sites / S Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
O60841 S186 Sugiyama EIF5B IF2 KIAA0741 EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O95218 S181 Sugiyama ZRANB2 ZIS ZNF265 DEDLsKyKLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRR
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05386 S101 Sugiyama RPLP1 RRP1 APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05387 S102 Sugiyama RPLP2 D11S2243E RPP2 PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P0DPH7 S48 Sugiyama TUBA3C TUBA2 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P14625 S64 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 tDDEVVQREEEAIQLDGLNAsQIRELREKSEKFAFQAEVNR
P22059 S190 Sugiyama OSBP OSBP1 QRWVTALELAKAKAVKMLAEsDEsGDEEsVsQtDKTELQNT
P22059 S193 Sugiyama OSBP OSBP1 VTALELAKAKAVKMLAEsDEsGDEEsVsQtDKTELQNTLRT
P68363 S48 Sugiyama TUBA1B HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P84098 T29 Sugiyama RPL19 RLAssVLRCGKKKVWLDPNEtNEIANANsRQQIRKLIKDGL
Q15637 S80 Sugiyama SF1 ZFM1 ZNF162 DLTRKLRtGDLGIPPNPEDRsPsPEPIyNsEGKRLNTREFR
Q15637 S82 Sugiyama SF1 ZFM1 ZNF162 TRKLRtGDLGIPPNPEDRsPsPEPIyNsEGKRLNTREFRTR
Q6P0Q8 S1019 Sugiyama MAST2 KIAA0807 MAST205 METRGRGTSQLAEGATAKAIsDLAVRRARHRLLsGDsTEKR
Q6P0Q8 S1032 Sugiyama MAST2 KIAA0807 MAST205 GATAKAIsDLAVRRARHRLLsGDsTEKRTARPVNKVIKSAS
Q6P0Q8 S775 Sugiyama MAST2 KIAA0807 MAST205 AQDLTSKLLHQNPLERLGTGsAYEVKQHPFFTGLDWTGLLR
Q6P0Q8 S806 Sugiyama MAST2 KIAA0807 MAST205 TGLDWTGLLRQKAEFIPQLEsEDDTsyFDTRsERyHHMDsE
Q6P0Q8 S811 Sugiyama MAST2 KIAA0807 MAST205 TGLLRQKAEFIPQLEsEDDTsyFDTRsERyHHMDsEDEEEV
Q6P0Q8 S817 Sugiyama MAST2 KIAA0807 MAST205 KAEFIPQLEsEDDTsyFDTRsERyHHMDsEDEEEVsEDGCL
Q6P0Q8 S825 Sugiyama MAST2 KIAA0807 MAST205 EsEDDTsyFDTRsERyHHMDsEDEEEVsEDGCLEIRQFSSC
Q6P0Q8 S832 Sugiyama MAST2 KIAA0807 MAST205 yFDTRsERyHHMDsEDEEEVsEDGCLEIRQFSSCsPRFNKV
Q6P0Q8 S874 Sugiyama MAST2 KIAA0807 MAST205 SSMERLSLLEERRtPPPTKRsLsEEKEDHsDGLAGLKGRDR
Q6P0Q8 S876 Sugiyama MAST2 KIAA0807 MAST205 MERLSLLEERRtPPPTKRsLsEEKEDHsDGLAGLKGRDRsW
Q6P0Q8 S883 Sugiyama MAST2 KIAA0807 MAST205 EERRtPPPTKRsLsEEKEDHsDGLAGLKGRDRsWVIGsPEI
Q6P0Q8 S931 Sugiyama MAST2 KIAA0807 MAST205 sEssHTESDSSPPMTVRRRCsGLLDAPRFPEGPEEASSTLR
Q6P0Q8 S992 Sugiyama MAST2 KIAA0807 MAST205 PVTEHSGEQRPKLDEEAVGRssGssPAMETRGRGTSQLAEG
Q6P0Q8 S993 Sugiyama MAST2 KIAA0807 MAST205 VTEHSGEQRPKLDEEAVGRssGssPAMETRGRGTSQLAEGA
Q6P0Q8 S995 Sugiyama MAST2 KIAA0807 MAST205 EHSGEQRPKLDEEAVGRssGssPAMETRGRGTSQLAEGATA
Q6P0Q8 S996 Sugiyama MAST2 KIAA0807 MAST205 HSGEQRPKLDEEAVGRssGssPAMETRGRGTSQLAEGATAK
Q6P0Q8 T1189 Sugiyama MAST2 KIAA0807 MAST205 VHTEVVELILKSGNKVAISTtPLENTSIKVGPARKGSYKAK
Q6P0Q8 T688 Sugiyama MAST2 KIAA0807 MAST205 LYEGHIEKDAREFLDKQVCGtPEyIAPEVILRQGYGKPVDW
Q6P0Q8 Y691 Sugiyama MAST2 KIAA0807 MAST205 GHIEKDAREFLDKQVCGtPEyIAPEVILRQGYGKPVDWWAM
Q6P0Q8 Y812 Sugiyama MAST2 KIAA0807 MAST205 GLLRQKAEFIPQLEsEDDTsyFDTRsERyHHMDsEDEEEVs
Q6P0Q8 Y820 Sugiyama MAST2 KIAA0807 MAST205 FIPQLEsEDDTsyFDTRsERyHHMDsEDEEEVsEDGCLEIR
Q6PEY2 S48 Sugiyama TUBA3E HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q71U36 S48 Sugiyama TUBA1A TUBA3 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q96HE7 S143 Sugiyama ERO1A ERO1L UNQ434/PRO865 EANNLIEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSD
Q9BQ16 T118 Sugiyama SPOCK3 TICN3 UNQ409/PRO771 HKVCIAQDSQTAVCISHRRLtHRMKEAGVDHRQWRGPILST
Q9BQE3 S48 Sugiyama TUBA1C TUBA6 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q9BX95 S112 Sugiyama SGPP1 SPP1 GLAAELGPAsPRRAGALRRNsLtGEEGQLARVSNWPLYCLF
Q9NVR5 S773 Sugiyama DNAAF2 C14orf104 KTU EFIKEKSATCSNEEKDNLNEsVITEEKETDGDHLsSLLNKT
Q9Y2H9 T550 Sugiyama MAST1 KIAA0973 SAST LYEGHIEKDAREFLDKQVCGtPEyIAPEVILRQGYGKPVDW
Q9Y2H9 Y553 Sugiyama MAST1 KIAA0973 SAST GHIEKDAREFLDKQVCGtPEyIAPEVILRQGYGKPVDWWAM
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Chromatin organization R-HSA-4839726 2.576040e-09 8.589 0 0
Cell Cycle R-HSA-1640170 2.723487e-09 8.565 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 3.049897e-09 8.516 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 3.419804e-09 8.466 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 9.331601e-09 8.030 0 0
PRC2 methylates histones and DNA R-HSA-212300 2.683420e-08 7.571 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.986569e-08 7.525 0 0
Chromatin modifying enzymes R-HSA-3247509 2.726044e-08 7.564 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 2.202749e-08 7.657 0 0
Nucleosome assembly R-HSA-774815 3.985222e-08 7.400 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 3.985222e-08 7.400 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 4.930447e-08 7.307 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 6.253500e-08 7.204 0 0
DNA Double Strand Break Response R-HSA-5693606 8.307593e-08 7.081 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.013037e-07 6.994 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.097984e-07 6.959 0 0
Mitotic Prophase R-HSA-68875 1.701764e-07 6.769 0 0
HDACs deacetylate histones R-HSA-3214815 1.874087e-07 6.727 0 0
Cellular Senescence R-HSA-2559583 2.601672e-07 6.585 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 2.984542e-07 6.525 0 0
Packaging Of Telomere Ends R-HSA-171306 3.723826e-07 6.429 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 3.723826e-07 6.429 0 0
HATs acetylate histones R-HSA-3214847 4.447770e-07 6.352 0 0
M Phase R-HSA-68886 6.604094e-07 6.180 0 0
DNA methylation R-HSA-5334118 7.950996e-07 6.100 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 7.519810e-07 6.124 0 0
Regulation of endogenous retroelements R-HSA-9842860 7.736927e-07 6.111 0 0
Cell Cycle, Mitotic R-HSA-69278 7.561570e-07 6.121 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 7.736927e-07 6.111 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 8.155965e-07 6.089 0 0
Meiotic synapsis R-HSA-1221632 1.558483e-06 5.807 0 0
Defective pyroptosis R-HSA-9710421 1.573077e-06 5.803 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.444677e-06 5.840 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 2.009392e-06 5.697 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 2.253407e-06 5.647 0 0
DNA Double-Strand Break Repair R-HSA-5693532 2.794221e-06 5.554 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 3.193552e-06 5.496 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 3.409024e-06 5.467 0 0
Chromosome Maintenance R-HSA-73886 3.937879e-06 5.405 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 4.647438e-06 5.333 0 0
Depyrimidination R-HSA-73928 4.647438e-06 5.333 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 4.836151e-06 5.316 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 5.137057e-06 5.289 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 5.549064e-06 5.256 0 0
Homology Directed Repair R-HSA-5693538 6.445958e-06 5.191 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 7.750671e-06 5.111 0 0
Estrogen-dependent gene expression R-HSA-9018519 8.290219e-06 5.081 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.222267e-05 4.913 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.287186e-05 4.890 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.317031e-05 4.880 0 0
Cleavage of the damaged purine R-HSA-110331 1.361235e-05 4.866 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 1.320556e-05 4.879 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.717215e-05 4.765 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.703514e-05 4.769 0 0
Depurination R-HSA-73927 1.780529e-05 4.749 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 3.806212e-05 4.420 0 0
Telomere Maintenance R-HSA-157579 5.066970e-05 4.295 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 5.679360e-05 4.246 0 0
G2/M Checkpoints R-HSA-69481 6.152882e-05 4.211 0 0
Diseases of programmed cell death R-HSA-9645723 6.416435e-05 4.193 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 6.493536e-05 4.188 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 6.666799e-05 4.176 0 0
Cell Cycle Checkpoints R-HSA-69620 6.754613e-05 4.170 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 7.446103e-05 4.128 0 0
RNA Polymerase I Transcription R-HSA-73864 7.950010e-05 4.100 0 0
RMTs methylate histone arginines R-HSA-3214858 9.526348e-05 4.021 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 1.316486e-04 3.881 0 0
DNA Repair R-HSA-73894 1.462110e-04 3.835 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.551922e-04 3.809 0 0
Meiosis R-HSA-1500620 2.336393e-04 3.631 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 2.461199e-04 3.609 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 2.461199e-04 3.609 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 2.461199e-04 3.609 0 0
Protein ubiquitination R-HSA-8852135 3.488079e-04 3.457 0 0
Assembly of the pre-replicative complex R-HSA-68867 3.785131e-04 3.422 0 0
Meiotic recombination R-HSA-912446 3.812267e-04 3.419 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 3.813169e-04 3.419 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 4.557453e-04 3.341 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 5.037906e-04 3.298 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 5.223313e-04 3.282 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 5.288580e-04 3.277 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 6.068663e-04 3.217 0 0
Deubiquitination R-HSA-5688426 5.990640e-04 3.223 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 6.161423e-04 3.210 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 6.161423e-04 3.210 0 0
HCMV Early Events R-HSA-9609690 6.512968e-04 3.186 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 6.863206e-04 3.163 0 0
TCF dependent signaling in response to WNT R-HSA-201681 7.706346e-04 3.113 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 8.161000e-04 3.088 0 0
Activation of HOX genes during differentiation R-HSA-5619507 8.161000e-04 3.088 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 8.188824e-04 3.087 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.027258e-03 2.988 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.205216e-03 2.919 0 0
Base Excision Repair R-HSA-73884 1.239716e-03 2.907 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.266940e-03 2.897 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.270115e-03 2.896 0 0
Apoptotic execution phase R-HSA-75153 1.301347e-03 2.886 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.417142e-03 2.849 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.424640e-03 2.846 0 0
Kinesins R-HSA-983189 1.641524e-03 2.785 0 0
Metalloprotease DUBs R-HSA-5689901 1.645599e-03 2.784 0 0
Mitotic Prometaphase R-HSA-68877 1.732463e-03 2.761 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.792164e-03 2.747 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 1.869733e-03 2.728 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.954197e-03 2.709 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.200197e-03 2.658 0 0
Ub-specific processing proteases R-HSA-5689880 2.183462e-03 2.661 0 0
mRNA Splicing R-HSA-72172 2.381389e-03 2.623 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.450004e-03 2.611 0 0
Transport of connexons to the plasma membrane R-HSA-190872 2.450004e-03 2.611 0 0
Cellular responses to stress R-HSA-2262752 2.601288e-03 2.585 0 0
ESR-mediated signaling R-HSA-8939211 2.647007e-03 2.577 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.651315e-03 2.577 0 0
DNA Replication Pre-Initiation R-HSA-69002 2.957352e-03 2.529 0 0
Cell junction organization R-HSA-446728 2.809857e-03 2.551 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.986033e-03 2.525 0 0
COPI-mediated anterograde transport R-HSA-6807878 3.059338e-03 2.514 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 3.259663e-03 2.487 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 3.259663e-03 2.487 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 3.260474e-03 2.487 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 3.584461e-03 2.446 0 0
Cellular responses to stimuli R-HSA-8953897 3.510538e-03 2.455 0 0
L1CAM interactions R-HSA-373760 3.486312e-03 2.458 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 4.026478e-03 2.395 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 4.323767e-03 2.364 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 4.338356e-03 2.363 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 4.418368e-03 2.355 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 4.418368e-03 2.355 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 4.591548e-03 2.338 0 0
Gene Silencing by RNA R-HSA-211000 4.920715e-03 2.308 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 5.036605e-03 2.298 0 0
G2/M Transition R-HSA-69275 5.706343e-03 2.244 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 5.920391e-03 2.228 0 0
Cell-Cell communication R-HSA-1500931 5.999099e-03 2.222 0 0
Adherens junctions interactions R-HSA-418990 6.128869e-03 2.213 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 6.289383e-03 2.201 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 6.480061e-03 2.188 0 0
Mitotic G2-G2/M phases R-HSA-453274 6.537217e-03 2.185 0 0
Unwinding of DNA R-HSA-176974 7.483153e-03 2.126 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 7.685443e-03 2.114 0 0
mTORC1-mediated signalling R-HSA-166208 7.730321e-03 2.112 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 7.845979e-03 2.105 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 8.300359e-03 2.081 0 0
DNA Replication R-HSA-69306 8.311819e-03 2.080 0 0
Amyloid fiber formation R-HSA-977225 9.197536e-03 2.036 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 9.607434e-03 2.017 0 0
Signaling by ALK in cancer R-HSA-9700206 9.607434e-03 2.017 0 0
PKMTs methylate histone lysines R-HSA-3214841 9.777372e-03 2.010 0 0
Cell-cell junction organization R-HSA-421270 1.010931e-02 1.995 0 0
Membrane Trafficking R-HSA-199991 1.028860e-02 1.988 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.105715e-02 1.956 0 0
Interleukin-12 signaling R-HSA-9020591 1.153115e-02 1.938 0 0
Axon guidance R-HSA-422475 1.158086e-02 1.936 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.189208e-02 1.925 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.272121e-02 1.895 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.358889e-02 1.867 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.300052e-02 1.886 0 0
Reproduction R-HSA-1474165 1.316129e-02 1.881 0 0
Mitotic Anaphase R-HSA-68882 1.436576e-02 1.843 0 0
Gene expression (Transcription) R-HSA-74160 1.494727e-02 1.825 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.517901e-02 1.819 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.519254e-02 1.818 0 0
Nervous system development R-HSA-9675108 1.672080e-02 1.777 0 0
PKR-mediated signaling R-HSA-9833482 1.701363e-02 1.769 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.726561e-02 1.763 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.726561e-02 1.763 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.726561e-02 1.763 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.726561e-02 1.763 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.726561e-02 1.763 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.848576e-02 1.733 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.761467e-02 1.754 0 0
mRNA 3'-end processing R-HSA-72187 1.887540e-02 1.724 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.765081e-02 1.753 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.853885e-02 1.732 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.935948e-02 1.713 0 0
Regulation of PTEN gene transcription R-HSA-8943724 2.069753e-02 1.684 0 0
Aggrephagy R-HSA-9646399 2.104365e-02 1.677 0 0
Centrosome maturation R-HSA-380287 2.133109e-02 1.671 0 0
Cap-dependent Translation Initiation R-HSA-72737 2.282610e-02 1.642 0 0
Eukaryotic Translation Initiation R-HSA-72613 2.282610e-02 1.642 0 0
HCMV Infection R-HSA-9609646 2.287210e-02 1.641 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.294980e-02 1.639 0 0
Gap junction assembly R-HSA-190861 2.331977e-02 1.632 0 0
Recycling pathway of L1 R-HSA-437239 2.385963e-02 1.622 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.431265e-02 1.614 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 2.507844e-02 1.601 0 0
ER to Golgi Anterograde Transport R-HSA-199977 2.753934e-02 1.560 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 2.759688e-02 1.559 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.759688e-02 1.559 0 0
Separation of Sister Chromatids R-HSA-2467813 2.849187e-02 1.545 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 2.947757e-02 1.531 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 3.023408e-02 1.520 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 3.367754e-02 1.473 0 0
RNA Polymerase III Transcription R-HSA-74158 3.023408e-02 1.520 0 0
MTOR signalling R-HSA-165159 3.024357e-02 1.519 0 0
Gap junction trafficking and regulation R-HSA-157858 2.975795e-02 1.526 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.978934e-02 1.526 0 0
Interleukin-12 family signaling R-HSA-447115 3.374628e-02 1.472 0 0
The NLRP3 inflammasome R-HSA-844456 3.446476e-02 1.463 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 3.457398e-02 1.461 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 3.494485e-02 1.457 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 3.533294e-02 1.452 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.641394e-02 1.439 0 0
AURKA Activation by TPX2 R-HSA-8854518 3.685073e-02 1.434 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 3.702363e-02 1.432 0 0
Sema4D in semaphorin signaling R-HSA-400685 3.735097e-02 1.428 0 0
Gap junction trafficking R-HSA-190828 3.776557e-02 1.423 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 4.062938e-02 1.391 0 0
Signaling by WNT R-HSA-195721 4.149893e-02 1.382 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 4.240247e-02 1.373 0 0
Myogenesis R-HSA-525793 4.298206e-02 1.367 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 4.357497e-02 1.361 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 4.357497e-02 1.361 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 4.454612e-02 1.351 0 0
Smooth Muscle Contraction R-HSA-445355 4.454612e-02 1.351 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 4.650531e-02 1.332 0 0
Signaling by APC mutants R-HSA-4839744 5.244859e-02 1.280 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 5.244859e-02 1.280 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 5.244859e-02 1.280 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 5.244859e-02 1.280 0 0
Interaction between L1 and Ankyrins R-HSA-445095 4.913415e-02 1.309 0 0
G alpha (12/13) signalling events R-HSA-416482 5.229855e-02 1.282 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 4.913415e-02 1.309 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 4.650531e-02 1.332 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 5.132190e-02 1.290 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 4.638217e-02 1.334 0 0
Co-inhibition by PD-1 R-HSA-389948 5.211759e-02 1.283 0 0
Protein folding R-HSA-391251 5.253911e-02 1.280 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 5.346283e-02 1.272 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 5.355932e-02 1.271 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 5.493519e-02 1.260 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 5.493519e-02 1.260 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 5.503946e-02 1.259 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 5.503946e-02 1.259 0 0
Semaphorin interactions R-HSA-373755 5.503946e-02 1.259 0 0
RAF activation R-HSA-5673000 5.509481e-02 1.259 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 5.593466e-02 1.252 0 0
NRAGE signals death through JNK R-HSA-193648 5.849266e-02 1.233 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 5.881927e-02 1.230 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 6.042369e-02 1.219 0 0
Chaperonin-mediated protein folding R-HSA-390466 6.054940e-02 1.218 0 0
Post NMDA receptor activation events R-HSA-438064 6.054940e-02 1.218 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 6.071460e-02 1.217 0 0
Regulation of TP53 Expression R-HSA-6804754 6.071460e-02 1.217 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 6.071460e-02 1.217 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 6.071460e-02 1.217 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 6.071460e-02 1.217 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 6.071460e-02 1.217 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 6.071460e-02 1.217 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 6.071460e-02 1.217 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 6.071460e-02 1.217 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 6.071460e-02 1.217 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 6.071460e-02 1.217 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 6.071460e-02 1.217 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 6.151813e-02 1.211 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 6.167921e-02 1.210 0 0
Signaling by Nuclear Receptors R-HSA-9006931 6.350226e-02 1.197 0 0
Nuclear Envelope Breakdown R-HSA-2980766 6.371692e-02 1.196 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 6.408232e-02 1.193 0 0
Signaling by GSK3beta mutants R-HSA-5339716 6.412527e-02 1.193 0 0
Signaling by AMER1 mutants R-HSA-4839748 6.412527e-02 1.193 0 0
Signaling by AXIN mutants R-HSA-4839735 6.412527e-02 1.193 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 7.704234e-02 1.113 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 7.704234e-02 1.113 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 7.704234e-02 1.113 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 7.704234e-02 1.113 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 7.704234e-02 1.113 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 7.704234e-02 1.113 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 7.080239e-02 1.150 0 0
Formation of a pool of free 40S subunits R-HSA-72689 6.851912e-02 1.164 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 7.704234e-02 1.113 0 0
Cilium Assembly R-HSA-5617833 7.249539e-02 1.140 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 7.884464e-02 1.103 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 8.042294e-02 1.095 0 0
UCH proteinases R-HSA-5689603 8.079344e-02 1.093 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 8.143807e-02 1.089 0 0
Oncogenic MAPK signaling R-HSA-6802957 8.536863e-02 1.069 0 0
Regulation of TP53 Activity R-HSA-5633007 8.590201e-02 1.066 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 8.601702e-02 1.065 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 8.725428e-02 1.059 0 0
Signaling by WNT in cancer R-HSA-4791275 8.795761e-02 1.056 0 0
DNA strand elongation R-HSA-69190 8.795761e-02 1.056 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 8.888346e-02 1.051 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 8.902437e-02 1.050 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 8.902437e-02 1.050 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 9.097752e-02 1.041 0 0
Amplification of signal from the kinetochores R-HSA-141424 9.097752e-02 1.041 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 9.115396e-02 1.040 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 9.115396e-02 1.040 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 9.115396e-02 1.040 0 0
TGFBR3 expression R-HSA-9839394 9.161106e-02 1.038 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 9.243620e-02 1.034 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.243620e-02 1.034 0 0
Mitotic Spindle Checkpoint R-HSA-69618 9.267867e-02 1.033 0 0
Signaling downstream of RAS mutants R-HSA-9649948 9.369018e-02 1.028 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 9.369018e-02 1.028 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 9.369018e-02 1.028 0 0
Signaling by RAS mutants R-HSA-6802949 9.369018e-02 1.028 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 9.447396e-02 1.025 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 9.447396e-02 1.025 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 9.447396e-02 1.025 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 9.447396e-02 1.025 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 9.659225e-02 1.015 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 9.710254e-02 1.013 0 0
Nuclear RNA decay R-HSA-9930044 9.734230e-02 1.012 0 0
Type I hemidesmosome assembly R-HSA-446107 9.783538e-02 1.010 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 9.783538e-02 1.010 0 0
Regulation of gap junction activity R-HSA-191650 1.203698e-01 0.919 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 1.203698e-01 0.919 0 0
ALK mutants bind TKIs R-HSA-9700645 1.184662e-01 0.926 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.227152e-01 0.911 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.227152e-01 0.911 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.186701e-01 0.926 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.215400e-01 0.915 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.190965e-01 0.924 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.179621e-01 0.928 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 1.203698e-01 0.919 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.024373e-01 0.990 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 1.095340e-01 0.960 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.227152e-01 0.911 0 0
RNA Polymerase II Transcription R-HSA-73857 1.081920e-01 0.966 0 0
Metabolism of RNA R-HSA-8953854 1.207619e-01 0.918 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.203698e-01 0.919 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.203698e-01 0.919 0 0
Selective autophagy R-HSA-9663891 1.091551e-01 0.962 0 0
Early Phase of HIV Life Cycle R-HSA-162594 1.196224e-01 0.922 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.141492e-01 0.943 0 0
Inflammasomes R-HSA-622312 1.259816e-01 0.900 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.264713e-01 0.898 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.272278e-01 0.895 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.293477e-01 0.888 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.338750e-01 0.873 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.338750e-01 0.873 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.338750e-01 0.873 0 0
Apoptosis R-HSA-109581 1.360705e-01 0.866 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.400175e-01 0.854 0 0
Prolonged ERK activation events R-HSA-169893 1.400175e-01 0.854 0 0
Negative regulation of FLT3 R-HSA-9706369 1.400175e-01 0.854 0 0
FLT3 signaling in disease R-HSA-9682385 1.400503e-01 0.854 0 0
2-LTR circle formation R-HSA-164843 1.405412e-01 0.852 0 0
PI3K/AKT activation R-HSA-198203 1.405412e-01 0.852 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.405412e-01 0.852 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.408812e-01 0.851 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 1.488444e-01 0.827 0 0
Notch-HLH transcription pathway R-HSA-350054 1.488444e-01 0.827 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 1.488444e-01 0.827 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.800277e-01 0.745 0 0
UNC93B1 deficiency - HSE R-HSA-5602415 1.800277e-01 0.745 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.800277e-01 0.745 0 0
ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 2.575028e-01 0.589 0 0
PI and PC transport between ER and Golgi membranes R-HSA-1483196 2.575028e-01 0.589 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 2.575028e-01 0.589 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 2.575028e-01 0.589 0 0
IKBKB deficiency causes SCID R-HSA-5602636 2.575028e-01 0.589 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 2.575028e-01 0.589 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 2.575028e-01 0.589 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 2.575028e-01 0.589 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 2.575028e-01 0.589 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 2.575028e-01 0.589 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 2.575028e-01 0.589 0 0
IRS activation R-HSA-74713 1.539255e-01 0.813 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 1.889946e-01 0.724 0 0
Signaling by RNF43 mutants R-HSA-5340588 1.889946e-01 0.724 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.276619e-01 0.485 0 0
Signalling to ERK5 R-HSA-198765 3.276619e-01 0.485 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 3.276619e-01 0.485 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.276619e-01 0.485 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 3.276619e-01 0.485 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.276619e-01 0.485 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.249922e-01 0.648 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 1.882230e-01 0.725 0 0
ERKs are inactivated R-HSA-202670 1.882230e-01 0.725 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 2.614303e-01 0.583 0 0
Regulation of PTEN localization R-HSA-8948747 2.614303e-01 0.583 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 2.614303e-01 0.583 0 0
SOS-mediated signalling R-HSA-112412 2.614303e-01 0.583 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 3.911954e-01 0.408 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 3.911954e-01 0.408 0 0
Defective HPRT1 disrupts guanine and hypoxanthine salvage R-HSA-9734281 3.911954e-01 0.408 0 0
3-Methylcrotonyl-CoA carboxylase deficiency R-HSA-9909438 3.911954e-01 0.408 0 0
Invadopodia formation R-HSA-8941237 3.911954e-01 0.408 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.772442e-01 0.751 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 2.979045e-01 0.526 0 0
Formation of annular gap junctions R-HSA-196025 2.979045e-01 0.526 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 2.393094e-01 0.621 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 2.393094e-01 0.621 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 1.807420e-01 0.743 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 2.656680e-01 0.576 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 3.340831e-01 0.476 0 0
ARMS-mediated activation R-HSA-170984 3.340831e-01 0.476 0 0
WNT mediated activation of DVL R-HSA-201688 3.340831e-01 0.476 0 0
Gap junction degradation R-HSA-190873 3.340831e-01 0.476 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 3.340831e-01 0.476 0 0
CASP8 activity is inhibited R-HSA-5218900 3.340831e-01 0.476 0 0
HCN channels R-HSA-1296061 4.487286e-01 0.348 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 4.487286e-01 0.348 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 4.487286e-01 0.348 0 0
Signaling by MAP2K mutants R-HSA-9652169 4.487286e-01 0.348 0 0
Signaling by LRP5 mutants R-HSA-5339717 4.487286e-01 0.348 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.487286e-01 0.348 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 4.487286e-01 0.348 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.382638e-01 0.623 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.947207e-01 0.711 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 3.696964e-01 0.432 0 0
Folding of actin by CCT/TriC R-HSA-390450 3.696964e-01 0.432 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.770797e-01 0.752 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.099138e-01 0.678 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 2.099138e-01 0.678 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 3.191861e-01 0.496 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.902676e-01 0.721 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 2.813071e-01 0.551 0 0
Translation initiation complex formation R-HSA-72649 1.685314e-01 0.773 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 4.045285e-01 0.393 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 5.008278e-01 0.300 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 5.008278e-01 0.300 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 5.008278e-01 0.300 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.008278e-01 0.300 0 0
Defective F9 activation R-HSA-9673221 5.008278e-01 0.300 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.008278e-01 0.300 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.906732e-01 0.720 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 2.577305e-01 0.589 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 2.742852e-01 0.562 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.728105e-01 0.429 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.728105e-01 0.429 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 3.728105e-01 0.429 0 0
G1 Phase R-HSA-69236 2.614039e-01 0.583 0 0
Cyclin D associated events in G1 R-HSA-69231 2.614039e-01 0.583 0 0
Thromboxane signalling through TP receptor R-HSA-428930 3.476295e-01 0.459 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 4.384090e-01 0.358 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 4.384090e-01 0.358 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 4.384090e-01 0.358 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 3.072310e-01 0.513 0 0
Regulation of signaling by CBL R-HSA-912631 4.255690e-01 0.371 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 4.255690e-01 0.371 0 0
Scavenging by Class F Receptors R-HSA-3000484 4.712069e-01 0.327 0 0
TRAIL signaling R-HSA-75158 5.480061e-01 0.261 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 5.480061e-01 0.261 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 5.480061e-01 0.261 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 5.480061e-01 0.261 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 5.480061e-01 0.261 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.878149e-01 0.541 0 0
MAP2K and MAPK activation R-HSA-5674135 3.599038e-01 0.444 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 4.141495e-01 0.383 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 4.141495e-01 0.383 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 4.141495e-01 0.383 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 2.941911e-01 0.531 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 4.513754e-01 0.345 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 4.513754e-01 0.345 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 4.513754e-01 0.345 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 4.513754e-01 0.345 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 3.054747e-01 0.515 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 2.980224e-01 0.526 0 0
Telomere Extension By Telomerase R-HSA-171319 4.360435e-01 0.360 0 0
HIV elongation arrest and recovery R-HSA-167287 4.360435e-01 0.360 0 0
Pausing and recovery of HIV elongation R-HSA-167290 4.360435e-01 0.360 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 4.766916e-01 0.322 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 4.766916e-01 0.322 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 4.022909e-01 0.395 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 4.576991e-01 0.339 0 0
Degradation of DVL R-HSA-4641258 4.424589e-01 0.354 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 4.424589e-01 0.354 0 0
Erythropoietin activates STAT5 R-HSA-9027283 5.907279e-01 0.229 0 0
STAT5 Activation R-HSA-9645135 5.907279e-01 0.229 0 0
Post-translational protein phosphorylation R-HSA-8957275 3.987927e-01 0.399 0 0
EGFR downregulation R-HSA-182971 5.000944e-01 0.301 0 0
Downstream signal transduction R-HSA-186763 5.000944e-01 0.301 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 5.207463e-01 0.283 0 0
Erythropoietin activates RAS R-HSA-9027284 5.622621e-01 0.250 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 5.622621e-01 0.250 0 0
Translesion synthesis by REV1 R-HSA-110312 5.622621e-01 0.250 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 4.590391e-01 0.338 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 4.590391e-01 0.338 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 4.695006e-01 0.328 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 5.490784e-01 0.260 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 5.409840e-01 0.267 0 0
Striated Muscle Contraction R-HSA-390522 5.607754e-01 0.251 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 5.607754e-01 0.251 0 0
Deadenylation of mRNA R-HSA-429947 5.718621e-01 0.243 0 0
Translesion synthesis by POLI R-HSA-5656121 5.900103e-01 0.229 0 0
Phosphorylation of the APC/C R-HSA-176412 5.900103e-01 0.229 0 0
Amino acids regulate mTORC1 R-HSA-9639288 5.631783e-01 0.249 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 5.800933e-01 0.237 0 0
Dual Incision in GG-NER R-HSA-5696400 5.800933e-01 0.237 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 5.939162e-01 0.226 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 5.939162e-01 0.226 0 0
Viral mRNA Translation R-HSA-192823 5.774319e-01 0.238 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 5.874845e-01 0.231 0 0
PTEN Regulation R-HSA-6807070 2.924334e-01 0.534 0 0
Extension of Telomeres R-HSA-180786 2.260579e-01 0.646 0 0
Signaling by EGFR in Cancer R-HSA-1643713 6.152179e-01 0.211 0 0
Ribosome-associated quality control R-HSA-9948299 3.726358e-01 0.429 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 3.599038e-01 0.444 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 3.993507e-01 0.399 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 1.755545e-01 0.756 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.398243e-01 0.620 0 0
DNA Damage Bypass R-HSA-73893 3.386056e-01 0.470 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 5.997151e-01 0.222 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 4.558750e-01 0.341 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 5.617326e-01 0.250 0 0
Activation of the pre-replicative complex R-HSA-68962 4.790649e-01 0.320 0 0
Integrin signaling R-HSA-354192 3.457938e-01 0.461 0 0
HSF1-dependent transactivation R-HSA-3371571 5.310050e-01 0.275 0 0
Integration of provirus R-HSA-162592 1.882230e-01 0.725 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 2.656680e-01 0.576 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 4.790649e-01 0.320 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 5.255951e-01 0.279 0 0
Resolution of D-Loop Structures R-HSA-5693537 2.099138e-01 0.678 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 1.947207e-01 0.711 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 5.331914e-01 0.273 0 0
Clathrin-mediated endocytosis R-HSA-8856828 5.314618e-01 0.275 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 5.105158e-01 0.292 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 4.295511e-01 0.367 0 0
Signaling by PDGF R-HSA-186797 3.933022e-01 0.405 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 1.772442e-01 0.751 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 3.032651e-01 0.518 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 4.045285e-01 0.393 0 0
Co-inhibition by CTLA4 R-HSA-389513 4.513754e-01 0.345 0 0
Peptide chain elongation R-HSA-156902 3.701276e-01 0.432 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 4.989153e-01 0.302 0 0
Chaperone Mediated Autophagy R-HSA-9613829 3.993507e-01 0.399 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 3.920738e-01 0.407 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.727935e-01 0.564 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 3.460507e-01 0.461 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 2.882202e-01 0.540 0 0
Ca2+ pathway R-HSA-4086398 4.127880e-01 0.384 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.784884e-01 0.748 0 0
Regulation by c-FLIP R-HSA-3371378 2.979045e-01 0.526 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 2.393094e-01 0.621 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 2.923449e-01 0.534 0 0
NF-kB is activated and signals survival R-HSA-209560 4.384090e-01 0.358 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 3.703671e-01 0.431 0 0
Orc1 removal from chromatin R-HSA-68949 3.863224e-01 0.413 0 0
Signal amplification R-HSA-392518 5.800933e-01 0.237 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 4.384090e-01 0.358 0 0
Fanconi Anemia Pathway R-HSA-6783310 2.764757e-01 0.558 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 3.568957e-01 0.447 0 0
Long-term potentiation R-HSA-9620244 1.975667e-01 0.704 0 0
Repression of WNT target genes R-HSA-4641265 4.712069e-01 0.327 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 4.712069e-01 0.327 0 0
Nuclear import of Rev protein R-HSA-180746 5.800933e-01 0.237 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 4.640020e-01 0.333 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 3.080809e-01 0.511 0 0
Adipogenesis R-HSA-9843745 5.970620e-01 0.224 0 0
Cellular response to heat stress R-HSA-3371556 5.804151e-01 0.236 0 0
Hedgehog 'off' state R-HSA-5610787 2.194810e-01 0.659 0 0
Rab regulation of trafficking R-HSA-9007101 4.269480e-01 0.370 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 5.388063e-01 0.269 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 4.428170e-01 0.354 0 0
Proteasome assembly R-HSA-9907900 5.874845e-01 0.231 0 0
Pyrophosphate hydrolysis R-HSA-71737 1.539255e-01 0.813 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 1.889946e-01 0.724 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.889946e-01 0.724 0 0
Abacavir transmembrane transport R-HSA-2161517 2.249922e-01 0.648 0 0
PTK6 Expression R-HSA-8849473 2.614303e-01 0.583 0 0
Dimerization of procaspase-8 R-HSA-69416 2.979045e-01 0.526 0 0
GP1b-IX-V activation signalling R-HSA-430116 3.340831e-01 0.476 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 5.008278e-01 0.300 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.008278e-01 0.300 0 0
PTK6 Down-Regulation R-HSA-8849472 5.008278e-01 0.300 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 5.008278e-01 0.300 0 0
Interleukin receptor SHC signaling R-HSA-912526 3.253996e-01 0.488 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 4.384090e-01 0.358 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 4.671062e-01 0.331 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 5.900103e-01 0.229 0 0
Killing mechanisms R-HSA-9664420 5.900103e-01 0.229 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 5.900103e-01 0.229 0 0
Tight junction interactions R-HSA-420029 5.939162e-01 0.226 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.723458e-01 0.764 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 3.989021e-01 0.399 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 5.105158e-01 0.292 0 0
Vesicle-mediated transport R-HSA-5653656 2.375584e-01 0.624 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 4.989153e-01 0.302 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 4.989153e-01 0.302 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 1.969871e-01 0.706 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 4.978878e-01 0.303 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 4.978878e-01 0.303 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 1.775932e-01 0.751 0 0
Oncogene Induced Senescence R-HSA-2559585 4.039738e-01 0.394 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.578764e-01 0.802 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.134352e-01 0.671 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 5.939257e-01 0.226 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 5.353075e-01 0.271 0 0
Frs2-mediated activation R-HSA-170968 2.393094e-01 0.621 0 0
Signaling by NOTCH R-HSA-157118 2.268711e-01 0.644 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.889946e-01 0.724 0 0
Processing of SMDT1 R-HSA-8949664 2.393094e-01 0.621 0 0
Formation of intermediate mesoderm R-HSA-9761174 3.696964e-01 0.432 0 0
Toxicity of botulinum toxin type G (botG) R-HSA-5250989 5.008278e-01 0.300 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 5.480061e-01 0.261 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.480061e-01 0.261 0 0
Switching of origins to a post-replicative state R-HSA-69052 4.127880e-01 0.384 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 5.907279e-01 0.229 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 5.907279e-01 0.229 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 5.907279e-01 0.229 0 0
S Phase R-HSA-69242 3.851324e-01 0.414 0 0
Eukaryotic Translation Termination R-HSA-72764 4.818250e-01 0.317 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 6.152179e-01 0.211 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 2.739119e-01 0.562 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 4.810289e-01 0.318 0 0
Negative regulation of MET activity R-HSA-6807004 4.513754e-01 0.345 0 0
DARPP-32 events R-HSA-180024 4.576991e-01 0.339 0 0
Neurexins and neuroligins R-HSA-6794361 2.494679e-01 0.603 0 0
ERK/MAPK targets R-HSA-198753 4.766916e-01 0.322 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 4.989153e-01 0.302 0 0
Diseases of Immune System R-HSA-5260271 4.989153e-01 0.302 0 0
Cellular response to starvation R-HSA-9711097 5.771447e-01 0.239 0 0
Circadian clock R-HSA-9909396 5.023062e-01 0.299 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 5.800933e-01 0.237 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 2.173583e-01 0.663 0 0
Spry regulation of FGF signaling R-HSA-1295596 2.923449e-01 0.534 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 3.191861e-01 0.496 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 3.728105e-01 0.429 0 0
p75NTR signals via NF-kB R-HSA-193639 5.622621e-01 0.250 0 0
Signalling to ERKs R-HSA-187687 4.039738e-01 0.394 0 0
Negative regulation of MAPK pathway R-HSA-5675221 3.599038e-01 0.444 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 6.152179e-01 0.211 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 4.614132e-01 0.336 0 0
Signaling by Hedgehog R-HSA-5358351 4.711260e-01 0.327 0 0
G0 and Early G1 R-HSA-1538133 5.207463e-01 0.283 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 5.510398e-01 0.259 0 0
Autophagy R-HSA-9612973 2.849464e-01 0.545 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 5.172558e-01 0.286 0 0
Opioid Signalling R-HSA-111885 4.699868e-01 0.328 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.575028e-01 0.589 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 2.575028e-01 0.589 0 0
Manipulation of host energy metabolism R-HSA-9636667 2.575028e-01 0.589 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.575028e-01 0.589 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 2.575028e-01 0.589 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 2.575028e-01 0.589 0 0
Proton/oligopeptide cotransporters R-HSA-427975 1.889946e-01 0.724 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 3.276619e-01 0.485 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 3.276619e-01 0.485 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 3.911954e-01 0.408 0 0
MET interacts with TNS proteins R-HSA-8875513 3.911954e-01 0.408 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 1.969871e-01 0.706 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 1.807420e-01 0.743 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 3.340831e-01 0.476 0 0
Alanine metabolism R-HSA-8964540 4.487286e-01 0.348 0 0
GABA synthesis R-HSA-888568 4.487286e-01 0.348 0 0
Cell-extracellular matrix interactions R-HSA-446353 2.923449e-01 0.534 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 4.045285e-01 0.393 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 5.008278e-01 0.300 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 3.253996e-01 0.488 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 3.728105e-01 0.429 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 3.728105e-01 0.429 0 0
Intraflagellar transport R-HSA-5620924 3.228555e-01 0.491 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 3.920738e-01 0.407 0 0
Pentose phosphate pathway disease R-HSA-6791465 5.480061e-01 0.261 0 0
Synthesis of PS R-HSA-1483101 5.480061e-01 0.261 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 3.845958e-01 0.415 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 3.711826e-01 0.430 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 4.766916e-01 0.322 0 0
Platelet calcium homeostasis R-HSA-418360 4.576991e-01 0.339 0 0
rRNA processing R-HSA-72312 2.992274e-01 0.524 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 4.989153e-01 0.302 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 5.900103e-01 0.229 0 0
MyD88-independent TLR4 cascade R-HSA-166166 5.510398e-01 0.259 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 5.800933e-01 0.237 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 4.934919e-01 0.307 0 0
Generic Transcription Pathway R-HSA-212436 3.832527e-01 0.417 0 0
Protein-protein interactions at synapses R-HSA-6794362 3.212096e-01 0.493 0 0
Synthesis of DNA R-HSA-69239 5.167543e-01 0.287 0 0
Death Receptor Signaling R-HSA-73887 2.684306e-01 0.571 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 4.468334e-01 0.350 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 4.468334e-01 0.350 0 0
STING mediated induction of host immune responses R-HSA-1834941 2.173583e-01 0.663 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 5.718621e-01 0.243 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 2.821250e-01 0.550 0 0
Cellular response to hypoxia R-HSA-1234174 5.864169e-01 0.232 0 0
Macroautophagy R-HSA-1632852 2.306787e-01 0.637 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.925746e-01 0.715 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 3.340831e-01 0.476 0 0
Eukaryotic Translation Elongation R-HSA-156842 4.322792e-01 0.364 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.747604e-01 0.561 0 0
G-protein mediated events R-HSA-112040 6.144343e-01 0.212 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 5.720377e-01 0.243 0 0
Signal Transduction R-HSA-162582 3.985726e-01 0.399 0 0
NGF-stimulated transcription R-HSA-9031628 1.973183e-01 0.705 0 0
Signal attenuation R-HSA-74749 3.696964e-01 0.432 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 3.460507e-01 0.461 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 3.457938e-01 0.461 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 4.790649e-01 0.320 0 0
FLT3 Signaling R-HSA-9607240 3.425300e-01 0.465 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.775932e-01 0.751 0 0
Response of endothelial cells to shear stress R-HSA-9860931 4.699868e-01 0.328 0 0
Ion homeostasis R-HSA-5578775 6.093541e-01 0.215 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 4.487286e-01 0.348 0 0
Signaling by LTK R-HSA-9842663 4.712069e-01 0.327 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 5.480061e-01 0.261 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 5.480061e-01 0.261 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 5.480061e-01 0.261 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 4.379016e-01 0.359 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 1.737313e-01 0.760 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 4.712069e-01 0.327 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 4.141495e-01 0.383 0 0
Regulation of BACH1 activity R-HSA-9708530 5.900103e-01 0.229 0 0
HCMV Late Events R-HSA-9610379 2.933333e-01 0.533 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 3.863224e-01 0.413 0 0
Neurodegenerative Diseases R-HSA-8863678 5.718621e-01 0.243 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 5.718621e-01 0.243 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 6.135873e-01 0.212 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.742852e-01 0.562 0 0
Ovarian tumor domain proteases R-HSA-5689896 4.424589e-01 0.354 0 0
TBC/RABGAPs R-HSA-8854214 5.704435e-01 0.244 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.575028e-01 0.589 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.889946e-01 0.724 0 0
Diseases of cellular response to stress R-HSA-9675132 3.276619e-01 0.485 0 0
Diseases of Cellular Senescence R-HSA-9630747 3.276619e-01 0.485 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.249922e-01 0.648 0 0
SLC-mediated transport of oligopeptides R-HSA-9959399 2.614303e-01 0.583 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 3.911954e-01 0.408 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 4.384090e-01 0.358 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 2.917612e-01 0.535 0 0
Activation of ATR in response to replication stress R-HSA-176187 3.457938e-01 0.461 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.480061e-01 0.261 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 4.766916e-01 0.322 0 0
Signaling by PDGFR in disease R-HSA-9671555 5.014504e-01 0.300 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 5.718621e-01 0.243 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.640857e-01 0.785 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.103367e-01 0.677 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 3.773277e-01 0.423 0 0
Formation of definitive endoderm R-HSA-9823730 4.513754e-01 0.345 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 5.574280e-01 0.254 0 0
Signaling by PTK6 R-HSA-8848021 5.574280e-01 0.254 0 0
Signaling by Hippo R-HSA-2028269 1.772442e-01 0.751 0 0
Protein hydroxylation R-HSA-9629569 4.513754e-01 0.345 0 0
Basigin interactions R-HSA-210991 4.766916e-01 0.322 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 4.790649e-01 0.320 0 0
Mitochondrial calcium ion transport R-HSA-8949215 5.014504e-01 0.300 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 4.121849e-01 0.385 0 0
Neurofascin interactions R-HSA-447043 2.249922e-01 0.648 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 3.696964e-01 0.432 0 0
PECAM1 interactions R-HSA-210990 4.045285e-01 0.393 0 0
Suppression of apoptosis R-HSA-9635465 4.045285e-01 0.393 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 3.457938e-01 0.461 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 5.907279e-01 0.229 0 0
Selenocysteine synthesis R-HSA-2408557 5.541604e-01 0.256 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 5.989142e-01 0.223 0 0
Signaling by ROBO receptors R-HSA-376176 2.235370e-01 0.651 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 6.083831e-01 0.216 0 0
PLC beta mediated events R-HSA-112043 5.275734e-01 0.278 0 0
Signaling by NTRKs R-HSA-166520 2.212492e-01 0.655 0 0
Programmed Cell Death R-HSA-5357801 3.121026e-01 0.506 0 0
Signaling by TGFBR3 R-HSA-9839373 4.468334e-01 0.350 0 0
Activation of RAC1 R-HSA-428540 1.882230e-01 0.725 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 2.614303e-01 0.583 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 2.614303e-01 0.583 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 3.340831e-01 0.476 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 3.340831e-01 0.476 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 3.696964e-01 0.432 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 2.326932e-01 0.633 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 5.008278e-01 0.300 0 0
RET signaling R-HSA-8853659 2.577305e-01 0.589 0 0
Uptake and function of anthrax toxins R-HSA-5210891 3.728105e-01 0.429 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 4.384090e-01 0.358 0 0
DAG and IP3 signaling R-HSA-1489509 2.764757e-01 0.558 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 5.480061e-01 0.261 0 0
Regulation of KIT signaling R-HSA-1433559 5.331914e-01 0.273 0 0
Signaling by LTK in cancer R-HSA-9842640 5.907279e-01 0.229 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 5.900103e-01 0.229 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 5.888723e-01 0.230 0 0
Regulation of necroptotic cell death R-HSA-5675482 5.409840e-01 0.267 0 0
Interleukin-7 signaling R-HSA-1266695 1.975667e-01 0.704 0 0
Nephrin family interactions R-HSA-373753 2.382638e-01 0.623 0 0
Prostanoid ligand receptors R-HSA-391908 4.045285e-01 0.393 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.539255e-01 0.813 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 2.614303e-01 0.583 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 2.614303e-01 0.583 0 0
Expression and Processing of Neurotrophins R-HSA-9036866 3.911954e-01 0.408 0 0
NGF processing R-HSA-167060 3.911954e-01 0.408 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 3.340831e-01 0.476 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.340831e-01 0.476 0 0
Interleukin-1 processing R-HSA-448706 3.340831e-01 0.476 0 0
Nef and signal transduction R-HSA-164944 5.907279e-01 0.229 0 0
MHC class II antigen presentation R-HSA-2132295 2.092906e-01 0.679 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 2.326932e-01 0.633 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 1.969871e-01 0.706 0 0
Calmodulin induced events R-HSA-111933 4.232756e-01 0.373 0 0
PI Metabolism R-HSA-1483255 5.658587e-01 0.247 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 3.696964e-01 0.432 0 0
Josephin domain DUBs R-HSA-5689877 3.696964e-01 0.432 0 0
CaM pathway R-HSA-111997 4.232756e-01 0.373 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 5.530444e-01 0.257 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 5.900103e-01 0.229 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 5.800933e-01 0.237 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 3.920738e-01 0.407 0 0
Ca-dependent events R-HSA-111996 5.530444e-01 0.257 0 0
Interleukin-37 signaling R-HSA-9008059 2.882202e-01 0.540 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 5.480061e-01 0.261 0 0
Growth hormone receptor signaling R-HSA-982772 5.490784e-01 0.260 0 0
TRP channels R-HSA-3295583 6.152179e-01 0.211 0 0
XBP1(S) activates chaperone genes R-HSA-381038 3.455187e-01 0.462 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 3.340831e-01 0.476 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 5.900103e-01 0.229 0 0
IRE1alpha activates chaperones R-HSA-381070 4.198279e-01 0.377 0 0
Platelet sensitization by LDL R-HSA-432142 3.993507e-01 0.399 0 0
Signaling by Leptin R-HSA-2586552 3.696964e-01 0.432 0 0
Synthesis and processing of ENV and VPU R-HSA-171286 3.276619e-01 0.485 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 5.028243e-01 0.299 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 5.331914e-01 0.273 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 6.060445e-01 0.217 0 0
Translesion synthesis by POLK R-HSA-5655862 6.164262e-01 0.210 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.164262e-01 0.210 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 6.164262e-01 0.210 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 6.164262e-01 0.210 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 6.164262e-01 0.210 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 6.164262e-01 0.210 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 6.164262e-01 0.210 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 6.164262e-01 0.210 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 6.164262e-01 0.210 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.164262e-01 0.210 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 6.164262e-01 0.210 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 6.176043e-01 0.209 0 0
Regulation of TNFR1 signaling R-HSA-5357905 6.204229e-01 0.207 0 0
Diseases of DNA repair R-HSA-9675135 6.204229e-01 0.207 0 0
Removal of aminoterminal propeptides from gamma-carboxylated proteins R-HSA-159782 6.294141e-01 0.201 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 6.294141e-01 0.201 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 6.294141e-01 0.201 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 6.294141e-01 0.201 0 0
Recycling of eIF2:GDP R-HSA-72731 6.294141e-01 0.201 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 6.294141e-01 0.201 0 0
Disinhibition of SNARE formation R-HSA-114516 6.294141e-01 0.201 0 0
Opsins R-HSA-419771 6.294141e-01 0.201 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 6.294141e-01 0.201 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.294141e-01 0.201 0 0
VLDL clearance R-HSA-8964046 6.294141e-01 0.201 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 6.294141e-01 0.201 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 6.294141e-01 0.201 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 6.294141e-01 0.201 0 0
Post-translational protein modification R-HSA-597592 6.313817e-01 0.200 0 0
G1/S Transition R-HSA-69206 6.317639e-01 0.199 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 6.349921e-01 0.197 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 6.357514e-01 0.197 0 0
Signaling by BMP R-HSA-201451 6.357514e-01 0.197 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 6.357514e-01 0.197 0 0
Triglyceride biosynthesis R-HSA-75109 6.357514e-01 0.197 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 6.399665e-01 0.194 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 6.399665e-01 0.194 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 6.399665e-01 0.194 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 6.415137e-01 0.193 0 0
Specification of primordial germ cells R-HSA-9827857 6.415137e-01 0.193 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 6.415137e-01 0.193 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 6.446455e-01 0.191 0 0
Mitochondrial biogenesis R-HSA-1592230 6.476583e-01 0.189 0 0
FOXO-mediated transcription R-HSA-9614085 6.510255e-01 0.186 0 0
Co-stimulation by CD28 R-HSA-389356 6.517450e-01 0.186 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 6.522216e-01 0.186 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 6.522216e-01 0.186 0 0
COPII-mediated vesicle transport R-HSA-204005 6.544545e-01 0.184 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 6.555068e-01 0.183 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 6.555068e-01 0.183 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 6.644455e-01 0.178 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 6.644455e-01 0.178 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 6.644455e-01 0.178 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 6.644455e-01 0.178 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 6.644455e-01 0.178 0 0
Toxicity of botulinum toxin type B (botB) R-HSA-5250958 6.644455e-01 0.178 0 0
Adrenoceptors R-HSA-390696 6.644455e-01 0.178 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 6.644455e-01 0.178 0 0
Co-stimulation by ICOS R-HSA-9927354 6.644455e-01 0.178 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 6.644455e-01 0.178 0 0
Nucleotide salvage defects R-HSA-9734207 6.644455e-01 0.178 0 0
SLC-mediated bile acid transport R-HSA-9958517 6.644455e-01 0.178 0 0
Alpha-defensins R-HSA-1462054 6.644455e-01 0.178 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 6.644455e-01 0.178 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 6.652880e-01 0.177 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 6.652880e-01 0.177 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 6.652880e-01 0.177 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 6.652880e-01 0.177 0 0
Ephrin signaling R-HSA-3928664 6.652880e-01 0.177 0 0
PKA activation R-HSA-163615 6.652880e-01 0.177 0 0
Presynaptic function of Kainate receptors R-HSA-500657 6.652880e-01 0.177 0 0
Polo-like kinase mediated events R-HSA-156711 6.652880e-01 0.177 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 6.652880e-01 0.177 0 0
Nephron development R-HSA-9831926 6.652880e-01 0.177 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 6.667741e-01 0.176 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 6.672267e-01 0.176 0 0
Regulation of mitotic cell cycle R-HSA-453276 6.672267e-01 0.176 0 0
Hedgehog 'on' state R-HSA-5632684 6.672267e-01 0.176 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 6.688986e-01 0.175 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 6.688986e-01 0.175 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 6.688986e-01 0.175 0 0
Signaling by Interleukins R-HSA-449147 6.715537e-01 0.173 0 0
Interleukin-1 signaling R-HSA-9020702 6.725642e-01 0.172 0 0
Signaling by Erythropoietin R-HSA-9006335 6.744796e-01 0.171 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 6.744796e-01 0.171 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 6.744796e-01 0.171 0 0
MAP kinase activation R-HSA-450294 6.798938e-01 0.168 0 0
EPH-Ephrin signaling R-HSA-2682334 6.814990e-01 0.167 0 0
Unfolded Protein Response (UPR) R-HSA-381119 6.822920e-01 0.166 0 0
Platelet activation, signaling and aggregation R-HSA-76002 6.833424e-01 0.165 0 0
Inositol phosphate metabolism R-HSA-1483249 6.848278e-01 0.164 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 6.850174e-01 0.164 0 0
HIV Transcription Elongation R-HSA-167169 6.850174e-01 0.164 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 6.850174e-01 0.164 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 6.850174e-01 0.164 0 0
Interleukin-2 family signaling R-HSA-451927 6.850174e-01 0.164 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 6.868012e-01 0.163 0 0
Signaling by TGFB family members R-HSA-9006936 6.874481e-01 0.163 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 6.877730e-01 0.163 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 6.877730e-01 0.163 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 6.877730e-01 0.163 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.877730e-01 0.163 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 6.877730e-01 0.163 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 6.926700e-01 0.159 0 0
DAP12 signaling R-HSA-2424491 6.926700e-01 0.159 0 0
Activation of BH3-only proteins R-HSA-114452 6.926700e-01 0.159 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 6.926700e-01 0.159 0 0
tRNA processing in the nucleus R-HSA-6784531 6.929607e-01 0.159 0 0
Heme signaling R-HSA-9707616 6.929607e-01 0.159 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 6.929607e-01 0.159 0 0
Muscle contraction R-HSA-397014 6.931319e-01 0.159 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 6.946200e-01 0.158 0 0
MAPK1 (ERK2) activation R-HSA-112411 6.961673e-01 0.157 0 0
Calcineurin activates NFAT R-HSA-2025928 6.961673e-01 0.157 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 6.961673e-01 0.157 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 6.961673e-01 0.157 0 0
p75NTR regulates axonogenesis R-HSA-193697 6.961673e-01 0.157 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 6.961673e-01 0.157 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 6.961673e-01 0.157 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 6.961673e-01 0.157 0 0
Lipophagy R-HSA-9613354 6.961673e-01 0.157 0 0
Regulated proteolysis of p75NTR R-HSA-193692 6.961673e-01 0.157 0 0
Cellular response to mitochondrial stress R-HSA-9840373 6.961673e-01 0.157 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 6.961673e-01 0.157 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 7.056686e-01 0.151 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 7.056686e-01 0.151 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 7.090001e-01 0.149 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 7.090001e-01 0.149 0 0
Signal transduction by L1 R-HSA-445144 7.090001e-01 0.149 0 0
Signaling by NODAL R-HSA-1181150 7.090001e-01 0.149 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 7.090001e-01 0.149 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 7.092579e-01 0.149 0 0
Interleukin-1 family signaling R-HSA-446652 7.099123e-01 0.149 0 0
Trafficking of AMPA receptors R-HSA-399719 7.100826e-01 0.149 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 7.100826e-01 0.149 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 7.100826e-01 0.149 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 7.100826e-01 0.149 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 7.100826e-01 0.149 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 7.153256e-01 0.145 0 0
ISG15 antiviral mechanism R-HSA-1169408 7.153256e-01 0.145 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 7.154151e-01 0.145 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 7.155708e-01 0.145 0 0
Nucleotide Excision Repair R-HSA-5696398 7.228513e-01 0.141 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 7.228626e-01 0.141 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 7.228626e-01 0.141 0 0
Binding and entry of HIV virion R-HSA-173107 7.248919e-01 0.140 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 7.248919e-01 0.140 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 7.248919e-01 0.140 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 7.248919e-01 0.140 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 7.248919e-01 0.140 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 7.248919e-01 0.140 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 7.248919e-01 0.140 0 0
Pexophagy R-HSA-9664873 7.248919e-01 0.140 0 0
Receptor Mediated Mitophagy R-HSA-8934903 7.248919e-01 0.140 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 7.248919e-01 0.140 0 0
Formation of apoptosome R-HSA-111458 7.248919e-01 0.140 0 0
Regulation of the apoptosome activity R-HSA-9627069 7.248919e-01 0.140 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 7.248919e-01 0.140 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 7.267254e-01 0.139 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 7.290060e-01 0.137 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 7.290060e-01 0.137 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 7.290060e-01 0.137 0 0
Lagging Strand Synthesis R-HSA-69186 7.290060e-01 0.137 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 7.290060e-01 0.137 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 7.332081e-01 0.135 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 7.332081e-01 0.135 0 0
MAPK family signaling cascades R-HSA-5683057 7.395002e-01 0.131 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 7.426098e-01 0.129 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 7.426098e-01 0.129 0 0
FGFR1 mutant receptor activation R-HSA-1839124 7.426098e-01 0.129 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 7.426098e-01 0.129 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 7.426098e-01 0.129 0 0
Cardiogenesis R-HSA-9733709 7.426098e-01 0.129 0 0
Signaling by SCF-KIT R-HSA-1433557 7.438864e-01 0.128 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 7.478320e-01 0.126 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 7.484973e-01 0.126 0 0
Platelet degranulation R-HSA-114608 7.487386e-01 0.126 0 0
HIV Life Cycle R-HSA-162587 7.488767e-01 0.126 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.504804e-01 0.125 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 7.509024e-01 0.124 0 0
vRNP Assembly R-HSA-192905 7.509024e-01 0.124 0 0
Synthesis of PI R-HSA-1483226 7.509024e-01 0.124 0 0
Bicarbonate transporters R-HSA-425381 7.509024e-01 0.124 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 7.509024e-01 0.124 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.509024e-01 0.124 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 7.563544e-01 0.121 0 0
Influenza Infection R-HSA-168255 7.570137e-01 0.121 0 0
EPHB-mediated forward signaling R-HSA-3928662 7.572156e-01 0.121 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 7.577499e-01 0.120 0 0
Effects of PIP2 hydrolysis R-HSA-114508 7.577499e-01 0.120 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 7.577499e-01 0.120 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 7.577499e-01 0.120 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 7.585067e-01 0.120 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 7.592581e-01 0.120 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 7.597534e-01 0.119 0 0
TNF signaling R-HSA-75893 7.597534e-01 0.119 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 7.597534e-01 0.119 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 7.597534e-01 0.119 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 7.636094e-01 0.117 0 0
Transcription of the HIV genome R-HSA-167172 7.637680e-01 0.117 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 7.637680e-01 0.117 0 0
Neurotransmitter release cycle R-HSA-112310 7.643674e-01 0.117 0 0
Downstream TCR signaling R-HSA-202424 7.643674e-01 0.117 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 7.655222e-01 0.116 0 0
FGFR2 alternative splicing R-HSA-6803529 7.655222e-01 0.116 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 7.655222e-01 0.116 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 7.655222e-01 0.116 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 7.655222e-01 0.116 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 7.660516e-01 0.116 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 7.660516e-01 0.116 0 0
TCR signaling R-HSA-202403 7.678193e-01 0.115 0 0
Signaling by MET R-HSA-6806834 7.685280e-01 0.114 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 7.721618e-01 0.112 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 7.721618e-01 0.112 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 7.721618e-01 0.112 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 7.721618e-01 0.112 0 0
Mitophagy R-HSA-5205647 7.721618e-01 0.112 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 7.721618e-01 0.112 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 7.744551e-01 0.111 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 7.744551e-01 0.111 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 7.744551e-01 0.111 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 7.744551e-01 0.111 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 7.744551e-01 0.111 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 7.744551e-01 0.111 0 0
Cellular response to chemical stress R-HSA-9711123 7.757669e-01 0.110 0 0
Potential therapeutics for SARS R-HSA-9679191 7.780348e-01 0.109 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 7.789538e-01 0.108 0 0
Transmission across Chemical Synapses R-HSA-112315 7.811025e-01 0.107 0 0
Syndecan interactions R-HSA-3000170 7.821230e-01 0.107 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 7.821230e-01 0.107 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 7.822530e-01 0.107 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 7.822530e-01 0.107 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 7.822530e-01 0.107 0 0
Dual incision in TC-NER R-HSA-6782135 7.823945e-01 0.107 0 0
Interleukin-17 signaling R-HSA-448424 7.844823e-01 0.105 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 7.858638e-01 0.105 0 0
Regulation of Apoptosis R-HSA-169911 7.858638e-01 0.105 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 7.858638e-01 0.105 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 7.896056e-01 0.103 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 7.896056e-01 0.103 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 7.930794e-01 0.101 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 7.939799e-01 0.100 0 0
Synthesis of PC R-HSA-1483191 7.939799e-01 0.100 0 0
Developmental Biology R-HSA-1266738 7.943402e-01 0.100 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 7.957822e-01 0.099 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 7.957822e-01 0.099 0 0
Polymerase switching R-HSA-69091 7.957822e-01 0.099 0 0
Leading Strand Synthesis R-HSA-69109 7.957822e-01 0.099 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 7.957822e-01 0.099 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 7.957822e-01 0.099 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 7.957822e-01 0.099 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 7.957822e-01 0.099 0 0
p75NTR recruits signalling complexes R-HSA-209543 7.957822e-01 0.099 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 7.957822e-01 0.099 0 0
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins R-HSA-159854 7.957822e-01 0.099 0 0
IRAK1 recruits IKK complex R-HSA-937039 7.957822e-01 0.099 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 7.957822e-01 0.099 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 7.957822e-01 0.099 0 0
Regulation of IFNG signaling R-HSA-877312 7.957822e-01 0.099 0 0
VLDLR internalisation and degradation R-HSA-8866427 7.957822e-01 0.099 0 0
MET activates RAS signaling R-HSA-8851805 7.957822e-01 0.099 0 0
Disorders of Nervous System Development R-HSA-9697154 7.957822e-01 0.099 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 7.957822e-01 0.099 0 0
Pervasive developmental disorders R-HSA-9005895 7.957822e-01 0.099 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 7.957822e-01 0.099 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 7.957822e-01 0.099 0 0
Interleukin-15 signaling R-HSA-8983432 7.957822e-01 0.099 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 7.957822e-01 0.099 0 0
OAS antiviral response R-HSA-8983711 7.957822e-01 0.099 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.967565e-01 0.099 0 0
Complex III assembly R-HSA-9865881 7.976823e-01 0.098 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 7.976823e-01 0.098 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 7.976823e-01 0.098 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 7.988757e-01 0.098 0 0
HSF1 activation R-HSA-3371511 7.988757e-01 0.098 0 0
Regulation of TP53 Degradation R-HSA-6804757 7.988757e-01 0.098 0 0
RUNX2 regulates bone development R-HSA-8941326 7.988757e-01 0.098 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 8.033491e-01 0.095 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 8.033491e-01 0.095 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 8.033491e-01 0.095 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 8.033491e-01 0.095 0 0
RAB geranylgeranylation R-HSA-8873719 8.033491e-01 0.095 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 8.033491e-01 0.095 0 0
Signaling by ERBB2 R-HSA-1227986 8.033491e-01 0.095 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 8.033491e-01 0.095 0 0
Host Interactions of HIV factors R-HSA-162909 8.043302e-01 0.095 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 8.112184e-01 0.091 0 0
RSV-host interactions R-HSA-9833110 8.112558e-01 0.091 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 8.122486e-01 0.090 0 0
Formation of the nephric duct R-HSA-9830364 8.122486e-01 0.090 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.122486e-01 0.090 0 0
HDMs demethylate histones R-HSA-3214842 8.122486e-01 0.090 0 0
Laminin interactions R-HSA-3000157 8.122486e-01 0.090 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 8.132110e-01 0.090 0 0
Interferon Signaling R-HSA-913531 8.132203e-01 0.090 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.150937e-01 0.089 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 8.150937e-01 0.089 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 8.150937e-01 0.089 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.150937e-01 0.089 0 0
Formation of axial mesoderm R-HSA-9796292 8.150937e-01 0.089 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 8.150937e-01 0.089 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 8.150937e-01 0.089 0 0
Diseases of nucleotide metabolism R-HSA-9735804 8.150937e-01 0.089 0 0
CD28 dependent Vav1 pathway R-HSA-389359 8.150937e-01 0.089 0 0
rRNA modification in the mitochondrion R-HSA-6793080 8.150937e-01 0.089 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.150937e-01 0.089 0 0
Maturation of nucleoprotein R-HSA-9683610 8.150937e-01 0.089 0 0
Interleukin-6 signaling R-HSA-1059683 8.150937e-01 0.089 0 0
NCAM signaling for neurite out-growth R-HSA-375165 8.226732e-01 0.085 0 0
Elastic fibre formation R-HSA-1566948 8.229140e-01 0.085 0 0
MET promotes cell motility R-HSA-8875878 8.229140e-01 0.085 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 8.229140e-01 0.085 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.229140e-01 0.085 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 8.258705e-01 0.083 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 8.258705e-01 0.083 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 8.258705e-01 0.083 0 0
Abacavir ADME R-HSA-2161522 8.258705e-01 0.083 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 8.258705e-01 0.083 0 0
SARS-CoV-1-host interactions R-HSA-9692914 8.260099e-01 0.083 0 0
PI3K Cascade R-HSA-109704 8.261284e-01 0.083 0 0
Toll-like Receptor Cascades R-HSA-168898 8.303134e-01 0.081 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 8.325801e-01 0.080 0 0
CRMPs in Sema3A signaling R-HSA-399956 8.325801e-01 0.080 0 0
NRIF signals cell death from the nucleus R-HSA-205043 8.325801e-01 0.080 0 0
Removal of the Flap Intermediate R-HSA-69166 8.325801e-01 0.080 0 0
Vitamin B2 (riboflavin) metabolism R-HSA-196843 8.325801e-01 0.080 0 0
Ciprofloxacin ADME R-HSA-9793528 8.325801e-01 0.080 0 0
HDL assembly R-HSA-8963896 8.325801e-01 0.080 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 8.339851e-01 0.079 0 0
Stabilization of p53 R-HSA-69541 8.339851e-01 0.079 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 8.339851e-01 0.079 0 0
Signaling by ALK R-HSA-201556 8.339851e-01 0.079 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.339851e-01 0.079 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 8.355976e-01 0.078 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 8.358761e-01 0.078 0 0
Hedgehog ligand biogenesis R-HSA-5358346 8.358761e-01 0.078 0 0
Signaling by NOTCH1 R-HSA-1980143 8.383303e-01 0.077 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 8.385035e-01 0.076 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 8.385962e-01 0.076 0 0
Synthesis of PE R-HSA-1483213 8.385962e-01 0.076 0 0
IGF1R signaling cascade R-HSA-2428924 8.404335e-01 0.075 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 8.444548e-01 0.073 0 0
Attenuation phase R-HSA-3371568 8.444548e-01 0.073 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 8.444548e-01 0.073 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 8.451624e-01 0.073 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 8.461542e-01 0.073 0 0
HIV Infection R-HSA-162906 8.468967e-01 0.072 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 8.479771e-01 0.072 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.484137e-01 0.071 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 8.484137e-01 0.071 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 8.484137e-01 0.071 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.484137e-01 0.071 0 0
G beta:gamma signalling through BTK R-HSA-8964315 8.484137e-01 0.071 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.484137e-01 0.071 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.484137e-01 0.071 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 8.484137e-01 0.071 0 0
DCC mediated attractive signaling R-HSA-418885 8.484137e-01 0.071 0 0
p38MAPK events R-HSA-171007 8.484137e-01 0.071 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 8.484137e-01 0.071 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.484137e-01 0.071 0 0
Protein repair R-HSA-5676934 8.484137e-01 0.071 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.484137e-01 0.071 0 0
Biotin transport and metabolism R-HSA-196780 8.484137e-01 0.071 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 8.484137e-01 0.071 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 8.484137e-01 0.071 0 0
Processive synthesis on the lagging strand R-HSA-69183 8.484137e-01 0.071 0 0
DNA Damage Reversal R-HSA-73942 8.484137e-01 0.071 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 8.487502e-01 0.071 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 8.498769e-01 0.071 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 8.504734e-01 0.070 0 0
Formation of the Early Elongation Complex R-HSA-113418 8.504734e-01 0.070 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 8.504734e-01 0.070 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 8.504734e-01 0.070 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 8.504734e-01 0.070 0 0
ER-Phagosome pathway R-HSA-1236974 8.523508e-01 0.069 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 8.540016e-01 0.069 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 8.543466e-01 0.068 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 8.543466e-01 0.068 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 8.543466e-01 0.068 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 8.543466e-01 0.068 0 0
Maturation of spike protein R-HSA-9694548 8.543466e-01 0.068 0 0
Glycolysis R-HSA-70171 8.586790e-01 0.066 0 0
Sensory processing of sound R-HSA-9659379 8.608763e-01 0.065 0 0
Termination of translesion DNA synthesis R-HSA-5656169 8.615488e-01 0.065 0 0
Regulation of gene expression in beta cells R-HSA-210745 8.615488e-01 0.065 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 8.615488e-01 0.065 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 8.615488e-01 0.065 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 8.615488e-01 0.065 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 8.624081e-01 0.064 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 8.627508e-01 0.064 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 8.627508e-01 0.064 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.627508e-01 0.064 0 0
Activation of the phototransduction cascade R-HSA-2485179 8.627508e-01 0.064 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 8.627508e-01 0.064 0 0
Activation of SMO R-HSA-5635838 8.627508e-01 0.064 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 8.627508e-01 0.064 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 8.627508e-01 0.064 0 0
Atorvastatin ADME R-HSA-9754706 8.627508e-01 0.064 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 8.636841e-01 0.064 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 8.636841e-01 0.064 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 8.636841e-01 0.064 0 0
HIV Transcription Initiation R-HSA-167161 8.636841e-01 0.064 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 8.636841e-01 0.064 0 0
Intra-Golgi traffic R-HSA-6811438 8.636841e-01 0.064 0 0
Signaling by FGFR1 in disease R-HSA-5655302 8.636841e-01 0.064 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 8.680817e-01 0.061 0 0
Neddylation R-HSA-8951664 8.700944e-01 0.060 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 8.703968e-01 0.060 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 8.709636e-01 0.060 0 0
Regulated Necrosis R-HSA-5218859 8.715655e-01 0.060 0 0
RAF/MAP kinase cascade R-HSA-5673001 8.715808e-01 0.060 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 8.718677e-01 0.060 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 8.718677e-01 0.060 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.718677e-01 0.060 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 8.724908e-01 0.059 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 8.757326e-01 0.058 0 0
Synthesis of PG R-HSA-1483148 8.757326e-01 0.058 0 0
Disorders of Developmental Biology R-HSA-9675151 8.757326e-01 0.058 0 0
Coenzyme A biosynthesis R-HSA-196783 8.757326e-01 0.058 0 0
tRNA modification in the mitochondrion R-HSA-6787450 8.757326e-01 0.058 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 8.757326e-01 0.058 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 8.779826e-01 0.057 0 0
Signaling by EGFR R-HSA-177929 8.779826e-01 0.057 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 8.779826e-01 0.057 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 8.807899e-01 0.055 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 8.807899e-01 0.055 0 0
Signaling by FGFR4 R-HSA-5654743 8.807899e-01 0.055 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 8.807899e-01 0.055 0 0
Response of Mtb to phagocytosis R-HSA-9637690 8.807899e-01 0.055 0 0
Molecules associated with elastic fibres R-HSA-2129379 8.814740e-01 0.055 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.814740e-01 0.055 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 8.814740e-01 0.055 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 8.851002e-01 0.053 0 0
IRS-mediated signalling R-HSA-112399 8.851805e-01 0.053 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.865609e-01 0.052 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 8.874872e-01 0.052 0 0
Glycogen storage diseases R-HSA-3229121 8.874872e-01 0.052 0 0
Synthesis of 15-eicosatetraenoic acid derivatives R-HSA-2142770 8.874872e-01 0.052 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 8.874872e-01 0.052 0 0
Catecholamine biosynthesis R-HSA-209905 8.874872e-01 0.052 0 0
Sulfide oxidation to sulfate R-HSA-1614517 8.874872e-01 0.052 0 0
Choline catabolism R-HSA-6798163 8.874872e-01 0.052 0 0
Cytokine Signaling in Immune system R-HSA-1280215 8.880065e-01 0.052 0 0
DAP12 interactions R-HSA-2172127 8.886047e-01 0.051 0 0
Netrin-1 signaling R-HSA-373752 8.886047e-01 0.051 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 8.904104e-01 0.050 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 8.913966e-01 0.050 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 8.917608e-01 0.050 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 8.920051e-01 0.050 0 0
Translation R-HSA-72766 8.948749e-01 0.048 0 0
Adaptive Immune System R-HSA-1280218 8.951546e-01 0.048 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 8.953582e-01 0.048 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 8.959577e-01 0.048 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 8.959577e-01 0.048 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 8.959577e-01 0.048 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 8.959577e-01 0.048 0 0
Signaling by FGFR3 R-HSA-5654741 8.959577e-01 0.048 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 8.973933e-01 0.047 0 0
Platelet homeostasis R-HSA-418346 8.978839e-01 0.047 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 8.981306e-01 0.047 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 8.981306e-01 0.047 0 0
Synaptic adhesion-like molecules R-HSA-8849932 8.981306e-01 0.047 0 0
PKA activation in glucagon signalling R-HSA-164378 8.981306e-01 0.047 0 0
Mismatch Repair R-HSA-5358508 8.981306e-01 0.047 0 0
Apoptotic factor-mediated response R-HSA-111471 8.981306e-01 0.047 0 0
Tie2 Signaling R-HSA-210993 8.981306e-01 0.047 0 0
snRNP Assembly R-HSA-191859 8.984715e-01 0.046 0 0
Metabolism of non-coding RNA R-HSA-194441 8.984715e-01 0.046 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 8.984715e-01 0.046 0 0
G-protein beta:gamma signalling R-HSA-397795 8.987173e-01 0.046 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 8.987173e-01 0.046 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.028712e-01 0.044 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 9.028712e-01 0.044 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 9.064341e-01 0.043 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 9.064341e-01 0.043 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.064341e-01 0.043 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.064341e-01 0.043 0 0
Heme degradation R-HSA-189483 9.064341e-01 0.043 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.072454e-01 0.042 0 0
Translesion Synthesis by POLH R-HSA-110320 9.077677e-01 0.042 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 9.077677e-01 0.042 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.077677e-01 0.042 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 9.077677e-01 0.042 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 9.077677e-01 0.042 0 0
Rap1 signalling R-HSA-392517 9.077677e-01 0.042 0 0
Specification of the neural plate border R-HSA-9834899 9.077677e-01 0.042 0 0
Diseases of hemostasis R-HSA-9671793 9.077677e-01 0.042 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 9.077677e-01 0.042 0 0
Maturation of nucleoprotein R-HSA-9694631 9.077677e-01 0.042 0 0
Neuronal System R-HSA-112316 9.090873e-01 0.041 0 0
Neutrophil degranulation R-HSA-6798695 9.093219e-01 0.041 0 0
Viral Messenger RNA Synthesis R-HSA-168325 9.103874e-01 0.041 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 9.103874e-01 0.041 0 0
Collagen degradation R-HSA-1442490 9.103874e-01 0.041 0 0
Signaling by NOTCH2 R-HSA-1980145 9.135979e-01 0.039 0 0
Iron uptake and transport R-HSA-917937 9.136907e-01 0.039 0 0
Gluconeogenesis R-HSA-70263 9.154658e-01 0.038 0 0
Mitochondrial protein import R-HSA-1268020 9.158656e-01 0.038 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.158656e-01 0.038 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.164936e-01 0.038 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 9.164936e-01 0.038 0 0
Glycogen synthesis R-HSA-3322077 9.164936e-01 0.038 0 0
Creatine metabolism R-HSA-71288 9.164936e-01 0.038 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.164936e-01 0.038 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.193103e-01 0.037 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.202443e-01 0.036 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.202443e-01 0.036 0 0
Phospholipid metabolism R-HSA-1483257 9.243309e-01 0.034 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.243944e-01 0.034 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 9.243944e-01 0.034 0 0
G-protein activation R-HSA-202040 9.243944e-01 0.034 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 9.243944e-01 0.034 0 0
Signalling to RAS R-HSA-167044 9.243944e-01 0.034 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.243944e-01 0.034 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.243944e-01 0.034 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 9.243944e-01 0.034 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.243944e-01 0.034 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.253722e-01 0.034 0 0
Insulin receptor signalling cascade R-HSA-74751 9.259319e-01 0.033 0 0
Ion transport by P-type ATPases R-HSA-936837 9.259319e-01 0.033 0 0
GPVI-mediated activation cascade R-HSA-114604 9.264070e-01 0.033 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.264070e-01 0.033 0 0
G1/S-Specific Transcription R-HSA-69205 9.264070e-01 0.033 0 0
Regulation of RAS by GAPs R-HSA-5658442 9.265548e-01 0.033 0 0
Azathioprine ADME R-HSA-9748787 9.265548e-01 0.033 0 0
PCP/CE pathway R-HSA-4086400 9.276671e-01 0.033 0 0
Integrin cell surface interactions R-HSA-216083 9.276671e-01 0.033 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.315482e-01 0.031 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 9.315482e-01 0.031 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 9.315482e-01 0.031 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 9.315482e-01 0.031 0 0
Attachment and Entry R-HSA-9694614 9.315482e-01 0.031 0 0
Ribavirin ADME R-HSA-9755088 9.315482e-01 0.031 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 9.315482e-01 0.031 0 0
Assembly Of The HIV Virion R-HSA-175474 9.315482e-01 0.031 0 0
The phototransduction cascade R-HSA-2514856 9.315837e-01 0.031 0 0
Degradation of AXIN R-HSA-4641257 9.321180e-01 0.031 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.321180e-01 0.031 0 0
NCAM1 interactions R-HSA-419037 9.321180e-01 0.031 0 0
Collagen chain trimerization R-HSA-8948216 9.321180e-01 0.031 0 0
Metabolism of folate and pterines R-HSA-196757 9.321180e-01 0.031 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 9.324265e-01 0.030 0 0
Signaling by VEGF R-HSA-194138 9.354312e-01 0.029 0 0
Viral Infection Pathways R-HSA-9824446 9.355325e-01 0.029 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 9.358290e-01 0.029 0 0
Signaling by FGFR2 R-HSA-5654738 9.358290e-01 0.029 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.362937e-01 0.029 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.362937e-01 0.029 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.374077e-01 0.028 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.380254e-01 0.028 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 9.380254e-01 0.028 0 0
Signaling by KIT in disease R-HSA-9669938 9.380254e-01 0.028 0 0
Cellular hexose transport R-HSA-189200 9.380254e-01 0.028 0 0
LDL clearance R-HSA-8964038 9.380254e-01 0.028 0 0
Regulation of PTEN stability and activity R-HSA-8948751 9.407026e-01 0.027 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.423045e-01 0.026 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.423045e-01 0.026 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.438901e-01 0.025 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.438901e-01 0.025 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 9.438901e-01 0.025 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.438901e-01 0.025 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.438901e-01 0.025 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.438901e-01 0.025 0 0
Interleukin-20 family signaling R-HSA-8854691 9.438901e-01 0.025 0 0
Mitochondrial protein degradation R-HSA-9837999 9.446632e-01 0.025 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.446632e-01 0.025 0 0
Glucose metabolism R-HSA-70326 9.466568e-01 0.024 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.468355e-01 0.024 0 0
Generation of second messenger molecules R-HSA-202433 9.468355e-01 0.024 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 9.468355e-01 0.024 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.468355e-01 0.024 0 0
Selenoamino acid metabolism R-HSA-2408522 9.475459e-01 0.023 0 0
Signaling by NOTCH3 R-HSA-9012852 9.486840e-01 0.023 0 0
G alpha (z) signalling events R-HSA-418597 9.486840e-01 0.023 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.492001e-01 0.023 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.492001e-01 0.023 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.492001e-01 0.023 0 0
Interleukin-6 family signaling R-HSA-6783589 9.492001e-01 0.023 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 9.510260e-01 0.022 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.510260e-01 0.022 0 0
Signaling by FGFR1 R-HSA-5654736 9.522882e-01 0.021 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.522882e-01 0.021 0 0
Stimuli-sensing channels R-HSA-2672351 9.523749e-01 0.021 0 0
G protein gated Potassium channels R-HSA-1296059 9.540079e-01 0.020 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.540079e-01 0.020 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.540079e-01 0.020 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.540079e-01 0.020 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 9.540079e-01 0.020 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.540079e-01 0.020 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 9.540079e-01 0.020 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.540079e-01 0.020 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.540079e-01 0.020 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.540079e-01 0.020 0 0
Late Phase of HIV Life Cycle R-HSA-162599 9.547942e-01 0.020 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.548998e-01 0.020 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.548998e-01 0.020 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.555856e-01 0.020 0 0
Regulation of CDH1 Function R-HSA-9764561 9.556549e-01 0.020 0 0
MET activates PTK2 signaling R-HSA-8874081 9.583609e-01 0.018 0 0
Sphingolipid catabolism R-HSA-9845614 9.583609e-01 0.018 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.583609e-01 0.018 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 9.583609e-01 0.018 0 0
Activation of GABAB receptors R-HSA-991365 9.584794e-01 0.018 0 0
GABA B receptor activation R-HSA-977444 9.584794e-01 0.018 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.584794e-01 0.018 0 0
Regulation of insulin secretion R-HSA-422356 9.586482e-01 0.018 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.587982e-01 0.018 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.594799e-01 0.018 0 0
Signaling by FGFR in disease R-HSA-1226099 9.617308e-01 0.017 0 0
Peroxisomal protein import R-HSA-9033241 9.617314e-01 0.017 0 0
Regulation of beta-cell development R-HSA-186712 9.617314e-01 0.017 0 0
Triglyceride metabolism R-HSA-8979227 9.617314e-01 0.017 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 9.623022e-01 0.017 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.623022e-01 0.017 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 9.623022e-01 0.017 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 9.623022e-01 0.017 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.623022e-01 0.017 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 9.623022e-01 0.017 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.623022e-01 0.017 0 0
Interferon gamma signaling R-HSA-877300 9.631990e-01 0.016 0 0
ABC-family proteins mediated transport R-HSA-382556 9.632803e-01 0.016 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.642458e-01 0.016 0 0
tRNA Aminoacylation R-HSA-379724 9.644674e-01 0.016 0 0
Prednisone ADME R-HSA-9757110 9.658706e-01 0.015 0 0
Insulin receptor recycling R-HSA-77387 9.658706e-01 0.015 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.658706e-01 0.015 0 0
Pyroptosis R-HSA-5620971 9.658706e-01 0.015 0 0
Integration of energy metabolism R-HSA-163685 9.665738e-01 0.015 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.670183e-01 0.015 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.676557e-01 0.014 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.676557e-01 0.014 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.676557e-01 0.014 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 9.676557e-01 0.014 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 9.676557e-01 0.014 0 0
Somitogenesis R-HSA-9824272 9.676557e-01 0.014 0 0
Gastrulation R-HSA-9758941 9.681209e-01 0.014 0 0
Translation of Structural Proteins R-HSA-9694635 9.688212e-01 0.014 0 0
Late endosomal microautophagy R-HSA-9615710 9.691014e-01 0.014 0 0
mRNA Capping R-HSA-72086 9.691014e-01 0.014 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 9.691014e-01 0.014 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.691014e-01 0.014 0 0
Glucagon-type ligand receptors R-HSA-420092 9.691014e-01 0.014 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.691014e-01 0.014 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.691014e-01 0.014 0 0
SARS-CoV-1 Infection R-HSA-9678108 9.699615e-01 0.013 0 0
Metabolism of proteins R-HSA-392499 9.701720e-01 0.013 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.720266e-01 0.012 0 0
Neurotransmitter clearance R-HSA-112311 9.720266e-01 0.012 0 0
Signaling by Insulin receptor R-HSA-74752 9.733143e-01 0.012 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.733143e-01 0.012 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.733747e-01 0.012 0 0
Protein localization R-HSA-9609507 9.740374e-01 0.011 0 0
SARS-CoV-2-host interactions R-HSA-9705683 9.743923e-01 0.011 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.746750e-01 0.011 0 0
Cargo concentration in the ER R-HSA-5694530 9.746750e-01 0.011 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 9.746750e-01 0.011 0 0
GPER1 signaling R-HSA-9634597 9.748624e-01 0.011 0 0
PPARA activates gene expression R-HSA-1989781 9.766052e-01 0.010 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.768993e-01 0.010 0 0
Degradation of CDH1 R-HSA-9766229 9.768993e-01 0.010 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.770728e-01 0.010 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.787761e-01 0.009 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.794760e-01 0.009 0 0
Hemostasis R-HSA-109582 9.799818e-01 0.009 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.812091e-01 0.008 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.812091e-01 0.008 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.812091e-01 0.008 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 9.829886e-01 0.007 0 0
NOD1/2 Signaling Pathway R-HSA-168638 9.829886e-01 0.007 0 0
eNOS activation R-HSA-203615 9.829886e-01 0.007 0 0
RA biosynthesis pathway R-HSA-5365859 9.829886e-01 0.007 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.829886e-01 0.007 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.829886e-01 0.007 0 0
Hyaluronan metabolism R-HSA-2142845 9.829886e-01 0.007 0 0
Signaling by FGFR R-HSA-190236 9.831787e-01 0.007 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.835520e-01 0.007 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.845572e-01 0.007 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.845996e-01 0.007 0 0
PERK regulates gene expression R-HSA-381042 9.845996e-01 0.007 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 9.849099e-01 0.007 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.860582e-01 0.006 0 0
Glycosphingolipid transport R-HSA-9845576 9.860582e-01 0.006 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.860582e-01 0.006 0 0
Paracetamol ADME R-HSA-9753281 9.861504e-01 0.006 0 0
Voltage gated Potassium channels R-HSA-1296072 9.873787e-01 0.006 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.873787e-01 0.006 0 0
Signaling by NOTCH4 R-HSA-9013694 9.877980e-01 0.005 0 0
Signaling by ERBB4 R-HSA-1236394 9.877980e-01 0.005 0 0
Synthesis of PA R-HSA-1483166 9.883406e-01 0.005 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.885742e-01 0.005 0 0
Purine salvage R-HSA-74217 9.885742e-01 0.005 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.885742e-01 0.005 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.887167e-01 0.005 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.896565e-01 0.005 0 0
Pentose phosphate pathway R-HSA-71336 9.896565e-01 0.005 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.899313e-01 0.004 0 0
Sialic acid metabolism R-HSA-4085001 9.901916e-01 0.004 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.901916e-01 0.004 0 0
Cardiac conduction R-HSA-5576891 9.903474e-01 0.004 0 0
Glycogen metabolism R-HSA-8982491 9.906363e-01 0.004 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.906363e-01 0.004 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.906440e-01 0.004 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.907035e-01 0.004 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.907054e-01 0.004 0 0
GABA receptor activation R-HSA-977443 9.910062e-01 0.004 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.910062e-01 0.004 0 0
Metabolism of polyamines R-HSA-351202 9.910062e-01 0.004 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.913640e-01 0.004 0 0
Aquaporin-mediated transport R-HSA-445717 9.917545e-01 0.004 0 0
Collagen formation R-HSA-1474290 9.919777e-01 0.003 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 9.920634e-01 0.003 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.923265e-01 0.003 0 0
Heme biosynthesis R-HSA-189451 9.923265e-01 0.003 0 0
Translation of Structural Proteins R-HSA-9683701 9.923265e-01 0.003 0 0
Ion channel transport R-HSA-983712 9.926598e-01 0.003 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.927963e-01 0.003 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 9.930536e-01 0.003 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.930536e-01 0.003 0 0
Complex I biogenesis R-HSA-6799198 9.930730e-01 0.003 0 0
Defensins R-HSA-1461973 9.937118e-01 0.003 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.939672e-01 0.003 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.943076e-01 0.002 0 0
Surfactant metabolism R-HSA-5683826 9.943076e-01 0.002 0 0
Amine ligand-binding receptors R-HSA-375280 9.943076e-01 0.002 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.944761e-01 0.002 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.946725e-01 0.002 0 0
The canonical retinoid cycle in rods (twilight vision) R-HSA-2453902 9.948471e-01 0.002 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.948471e-01 0.002 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.948691e-01 0.002 0 0
Kidney development R-HSA-9830369 9.951203e-01 0.002 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.951203e-01 0.002 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.952140e-01 0.002 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.953354e-01 0.002 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.955312e-01 0.002 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.957775e-01 0.002 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 9.959080e-01 0.002 0 0
Parasitic Infection Pathways R-HSA-9824443 9.961301e-01 0.002 0 0
Leishmania infection R-HSA-9658195 9.961301e-01 0.002 0 0
Metal ion SLC transporters R-HSA-425410 9.961777e-01 0.002 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.961777e-01 0.002 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.962069e-01 0.002 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.965400e-01 0.002 0 0
ECM proteoglycans R-HSA-3000178 9.965705e-01 0.001 0 0
Metabolism of porphyrins R-HSA-189445 9.965705e-01 0.001 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.966391e-01 0.001 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 9.968610e-01 0.001 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.968680e-01 0.001 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.971272e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.971649e-01 0.001 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.971649e-01 0.001 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.979457e-01 0.001 0 0
Interleukin-10 signaling R-HSA-6783783 9.981591e-01 0.001 0 0
Cholesterol biosynthesis R-HSA-191273 9.981591e-01 0.001 0 0
ABC transporter disorders R-HSA-5619084 9.981591e-01 0.001 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.982771e-01 0.001 0 0
tRNA processing R-HSA-72306 9.983030e-01 0.001 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.983164e-01 0.001 0 0
Mitochondrial translation elongation R-HSA-5389840 9.983758e-01 0.001 0 0
Potassium Channels R-HSA-1296071 9.983758e-01 0.001 0 0
Dectin-2 family R-HSA-5621480 9.984405e-01 0.001 0 0
Mitochondrial translation initiation R-HSA-5368286 9.986241e-01 0.001 0 0
Interferon alpha/beta signaling R-HSA-909733 9.988097e-01 0.001 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.988097e-01 0.001 0 0
Nucleotide salvage R-HSA-8956321 9.989532e-01 0.000 0 0
SARS-CoV Infections R-HSA-9679506 9.990599e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.992503e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.994244e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.994285e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.994974e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.995732e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.995732e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.996104e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.996137e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.996137e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.996397e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.997136e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.997240e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.997457e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.998078e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.998481e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.998526e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.998575e-01 0.000 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.998749e-01 0.000 0 0
Leishmania phagocytosis R-HSA-9664417 9.998749e-01 0.000 0 0
Parasite infection R-HSA-9664407 9.998749e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.998828e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.999096e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999217e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999320e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999365e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999382e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999497e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999519e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999533e-01 0.000 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.999574e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999662e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999662e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999712e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999774e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999843e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999890e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999899e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.999921e-01 0.000 0 0
Developmental Cell Lineages R-HSA-9734767 9.999926e-01 0.000 0 0
Immune System R-HSA-168256 9.999929e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999932e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.999960e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999979e-01 0.000 0 0
SLC transporter disorders R-HSA-5619102 9.999982e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999986e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999988e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999988e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999991e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999992e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999992e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999995e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999996e-01 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 9.999999e-01 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.999999e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999999e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Keratinization R-HSA-6805567 1.000000e+00 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 1.000000e+00 0.000 0 0
Innate Immune System R-HSA-168249 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Disease R-HSA-1643685 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways