MAP2K7

TYR version of PSPA with Y as phospho-acceptor
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
O00165 S153 Sugiyama HAX1 HS1BP1 PDSHQPRIFGGVLESDARSEsPQPAPDWGsQRPFHRFDDVW
O14733 S277 Sugiyama MAP2K7 JNKK2 MEK7 MKK7 PRKMK7 SKK4 IKLCDFGIsGRLVDsKAKtRsAGCAAYMAPERIDPPDPTKP
O14733 S61 Sugiyama MAP2K7 JNKK2 MEK7 MKK7 PRKMK7 SKK4 PtLQLPLANDGGsRsPssEssPQHPtPPARPRHMLGLPSTL
O14733 S89 Sugiyama MAP2K7 JNKK2 MEK7 MKK7 PRKMK7 SKK4 ARPRHMLGLPSTLFTPRSMEsIEIDQKLQEIMKQTGyLTIG
O14733 T275 Sugiyama MAP2K7 JNKK2 MEK7 MKK7 PRKMK7 SKK4 GQIKLCDFGIsGRLVDsKAKtRsAGCAAYMAPERIDPPDPT
O14733 T66 Sugiyama MAP2K7 JNKK2 MEK7 MKK7 PRKMK7 SKK4 PLANDGGsRsPssEssPQHPtPPARPRHMLGLPSTLFTPRS
O14733 Y105 Sugiyama MAP2K7 JNKK2 MEK7 MKK7 PRKMK7 SKK4 RSMEsIEIDQKLQEIMKQTGyLTIGGQRYQAEINDLENLGE
O14974 S695 Sugiyama PPP1R12A MBS MYPT1 DEEsEsQRKARSRQARQsRRstQGVtLtDLQEAEKtIGRSR
O15264 T180 GPS6|SIGNOR|EPSD MAPK13 PRKM13 SAPK4 EDCELKILDFGLARHADAEMtGyVVtRWYRAPEVILSWMHY
O15264 Y182 SIGNOR MAPK13 PRKM13 SAPK4 CELKILDFGLARHADAEMtGyVVtRWYRAPEVILSWMHYNQ
O43852 T196 Sugiyama CALU FtAFLHPEEyDyMKDIVVQEtMEDIDKNADGFIDLEEyIGD
O60716 S252 Sugiyama CTNND1 KIAA0384 sRVtRIEERyRPsMEGyRAPsRQDVyGPQPQVRVGGssVDL
O60841 S182 Sugiyama EIF5B IF2 KIAA0741 DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O60841 S186 Sugiyama EIF5B IF2 KIAA0741 EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O75131 S242 Sugiyama CPNE3 CPN3 KIAA0636 SHDLIGTFQTTMTKLKEAsRssPVEFECINEKKRQKKKSYK
P00558 Y161 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 KAEPAKIEAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNL
P04075 S354 Sugiyama ALDOA ALDA ANsLACQGKytPsGQAGAAAsEsLFVsNHAy__________
P04075 S356 Sugiyama ALDOA ALDA sLACQGKytPsGQAGAAAsEsLFVsNHAy____________
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S360 Sugiyama ALDOA ALDA QGKytPsGQAGAAAsEsLFVsNHAy________________
P04075 Y364 Sugiyama ALDOA ALDA tPsGQAGAAAsEsLFVsNHAy____________________
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 S321 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IALNDHFVKLIsWyDNEFGysNRVVDLMAHMAsKE______
P04406 T237 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05386 S101 Sugiyama RPLP1 RRP1 APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05386 S104 Sugiyama RPLP1 RRP1 tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387 S102 Sugiyama RPLP2 D11S2243E RPP2 PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05387 S105 Sugiyama RPLP2 D11S2243E RPP2 GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P07205 Y161 Sugiyama PGK2 PGKB KAEPDKIEAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNL
P07900 S52 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P08238 S460 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB GIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQ
P13639 S587 Sugiyama EEF2 EF2 CIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKAR
P13639 S593 Sugiyama EEF2 EF2 SDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGL
P13639 Y579 Sugiyama EEF2 EF2 KDLEEDHACIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKH
P14314 T115 Sugiyama PRKCSH G19P1 GVCDCCDGtDEyNsGVICENtCKEKGRKEREsLQQMAEVtR
P14618 S202 Sugiyama PKM OIP3 PK2 PK3 PKM2 SLQVKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVs
P14625 S64 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 tDDEVVQREEEAIQLDGLNAsQIRELREKSEKFAFQAEVNR
P17812 S575 Sugiyama CTPS1 CTPS LQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD____
P18621 S5 Sugiyama RPL17 ________________MVRysLDPENPtKsCKSRGSNLRVH
P21333 S1084 Sugiyama FLNA FLN FLN1 PTKPSKVKAFGPGLQGGsAGsPARFtIDTKGAGTGGLGLTV
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P35269 T389 Sugiyama GTF2F1 RAP74 PPKRERKPsGGSSRGNsRPGtPsAEGGstsstLRAAASKLE
P35568 S312 SIGNOR IRS1 PPPSQVGLTRRsRtEsItAtsPAsMVGGKPGsFRVRAssDG
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P40818 S719 Sugiyama USP8 KIAA0055 UBPY KPQIPAERDREPSKLKRsyssPDItQAIQEEEKRKPTVtPT
P42166 S159 Sugiyama TMPO LAP2 RKLYEKKLLKLREQGtEsRsstPLPtIsssAENtRQNGsND
P42166 T160 Sugiyama TMPO LAP2 KLYEKKLLKLREQGtEsRsstPLPtIsssAENtRQNGsNDs
P42167 S159 Sugiyama TMPO LAP2 RKLYEKKLLKLREQGTESRsstPLPTISsSAENTRQNGSND
P42167 T160 Sugiyama TMPO LAP2 KLYEKKLLKLREQGTESRsstPLPTISsSAENTRQNGSNDS
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P45983 T183 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP MAPK8 JNK1 PRKM8 SAPK1 SAPK1C CTLKILDFGLARTAGtsFMMtPyVVtRyYRAPEVILGMGYK
P45983 Y185 SIGNOR|ELM|iPTMNet|EPSD|PSP MAPK8 JNK1 PRKM8 SAPK1 SAPK1C LKILDFGLARTAGtsFMMtPyVVtRyYRAPEVILGMGYKEN
P45984 S407 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP MAPK9 JNK2 PRKM9 SAPK1A PSQSSSINDISSMSTEQtLAsDTDSSLDASTGPLEGCR___
P45984 T183 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP MAPK9 JNK2 PRKM9 SAPK1A CTLKILDFGLARTACTNFMMtPyVVtRYYRAPEVILGMGYK
P45984 T404 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP MAPK9 JNK2 PRKM9 SAPK1A NATPSQSSSINDISSMSTEQtLAsDTDSSLDASTGPLEGCR
P45984 Y185 SIGNOR|iPTMNet|EPSD MAPK9 JNK2 PRKM9 SAPK1A LKILDFGLARTACTNFMMtPyVVtRYYRAPEVILGMGYKEN
P52272 S633 Sugiyama HNRNPM HNRPM NAGR1 GGGGAsFDRAIEMERGNFGGsFAGsFGGAGGHAPGVARKAC
P52272 S637 Sugiyama HNRNPM HNRPM NAGR1 AsFDRAIEMERGNFGGsFAGsFGGAGGHAPGVARKACQIFV
P53779 T221 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP MAPK10 JNK3 JNK3A PRKM10 SAPK1B CTLKILDFGLARTAGtsFMMtPyVVtRyYRAPEVILGMGYK
P60709 S323 Sugiyama ACTB ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709 T324 Sugiyama ACTB tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P61254 T8 Sugiyama RPL26 _____________MKFNPFVtsDRsKNRKRHFNAPsHIRRK
P62263 T133 Sugiyama RPS14 PRO2640 QsALRALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL__
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62736 S325 Sugiyama ACTA2 ACTSA ACTVS GIG46 tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736 T326 Sugiyama ACTA2 ACTSA ACTVS GIG46 TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P63261 S323 Sugiyama ACTG1 ACTG ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261 T324 Sugiyama ACTG1 ACTG tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63267 S324 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267 T325 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68032 S325 Sugiyama ACTC1 ACTC tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032 T326 Sugiyama ACTC1 ACTC TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68133 S325 Sugiyama ACTA1 ACTA TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133 T326 Sugiyama ACTA1 ACTA TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
Q00613 S363 Sugiyama HSF1 HSTF1 AsVTALtDARGHTDtEGRPPsPPPtstPEKCLsVACLDKNE
Q13158 S194 SIGNOR|EPSD|PSP FADD MORT1 GIG3 ADLVQEVQQARDLQNRsGAMsPMsWNsDAsTSEAS______
Q13283 S232 Sugiyama G3BP1 G3BP EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q14568 S52 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q15637 S82 Sugiyama SF1 ZFM1 ZNF162 TRKLRtGDLGIPPNPEDRsPsPEPIyNsEGKRLNTREFRTR
Q6UN15 S492 Sugiyama FIP1L1 FIP1 RHE DRDRDRERERTRERERERDHsPtPsVFNsDEERyRYREYAE
Q7L2J0 S217 Sugiyama MEPCE BCDIN3 LNSLLDEEVSRtLNAEtPKssPLPAKGRDPVEILIPKDItD
Q7L2J0 S69 Sugiyama MEPCE BCDIN3 RGPGRCAPsAGsPAAAVGREsPGAAAtsSSGPQAQQHRGGG
Q7L2J0 T213 Sugiyama MEPCE BCDIN3 DPLNLNSLLDEEVSRtLNAEtPKssPLPAKGRDPVEILIPK
Q7Z417 S652 Sugiyama NUFIP2 KIAA1321 PIG1 NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q8IZ21 S118 Sugiyama PHACTR4 PRO2963 PSDAMLKNGHTTPIGNARsssPVQVEEEPVRLAsLRKAIPE
Q8N684 T203 Sugiyama CPSF7 GGIPPRAHsRDssDsADGRAtPsENLVPSSARVDKPPSVLP
Q96GM8 S420 Sugiyama TOE1 KNDLEMGIKAARPEIADRATsEVPGsQAsPNPVPGDGLHRA
Q96MU7 S308 Sugiyama YTHDC1 KIAA1966 YT521 GSGTDGsDEKKKERKRARGIsPIVFDRsGssAsESYAGsEK
Q96S44 T8 Sugiyama TP53RK C20orf64 PRPK _____________MAAARAttPADGEEPAPEAEALAAARER
Q99759 T153 Sugiyama MAP3K3 MAPKKK3 MEKK3 HSGVSRQVRIKAsQsAGDINtIyQPPEPRsRHLsVssQNPG
Q9BQE3 S439 Sugiyama TUBA1C TUBA6 SEAREDMAALEKDyEEVGADsADGEDEGEEy__________
Q9BTA9 S525 Sugiyama WAC KIAA1844 QGHEPVsPRSLQRsssQRsPsPGPNHtsNssNAsNATVVPQ
Q9C0C2 S672 Sugiyama TNKS1BP1 KIAA1741 TAB182 TLARAETtQARtEAQDLCRAsPEPPGPEsSSRWLDDLLAsP
Q9H4A3 S1261 Sugiyama WNK1 HSN2 KDP KIAA0344 PRKWNK1 GIPTSSLTQVVHSAGRRFIVsPVPEsRLRESKVFPSEITDT
Q9H6F5 S91 Sugiyama CCDC86 CYCLON RLQQGAGLEsPQGQPEPGAAsPQRQQDLHLEsPQRQPEysP
Q9H7N4 S498 Sugiyama SCAF1 SFRS19 SRA1 GGLDLRRKILTQRRERyRQRsPsPAPAPAPAAAAGPPTRKK
Q9H7N4 S500 Sugiyama SCAF1 SFRS19 SRA1 LDLRRKILTQRRERyRQRsPsPAPAPAPAAAAGPPTRKKSR
Q9NPI6 S525 Sugiyama DCP1A SMIF SVFQQTVTRSSDLERKAssPsPLtIGtPEsQRKPSIILSKs
Q9UMZ2 S1087 Sugiyama SYNRG AP1GBP1 SYNG QGSHKRsLsLGDKEIsRssPsPALEQPFRDRsNtLNEKPAL
Q9UNX3 T8 Sugiyama RPL26L1 RPL26P1 _____________MKFNPFVtsDRsKNRKRHFNAPSHVRRK
Q9UQ35 S1103 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 sPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEFsA
Q9UQ35 S1648 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 APRALPRRSRSGSSSKGRGPsPEGssstEssPEHPPKSRTA
Q9UQ35 S2132 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 SRMsCFsRPsMsPtPLDRCRsPGMLEPLGssRtPMsVLQQA
Q9UQ35 S876 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 tsPQANEQsVtPQRRsCFEssPDPELKsRtPsRHsCsGssP
Q9UQ35 T328 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 APFsEPGttstQRPssPEtAtKQPssPYEDKDKDKKEKsAt
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
mRNA Splicing - Major Pathway R-HSA-72163 2.635436e-11 10.579 0 0
mRNA Splicing R-HSA-72172 5.896938e-11 10.229 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 8.185652e-10 9.087 0 0
Signal Transduction R-HSA-162582 7.458606e-07 6.127 0 0
Signaling by LTK R-HSA-9842663 1.026773e-06 5.989 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 7.156634e-06 5.145 0 0
Metabolism of RNA R-HSA-8953854 1.758972e-05 4.755 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.962891e-05 4.707 0 0
Cytokine Signaling in Immune system R-HSA-1280215 4.727899e-05 4.325 1 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 5.950301e-05 4.225 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 7.543090e-05 4.122 0 0
Signaling by Interleukins R-HSA-449147 7.604595e-05 4.119 1 0
Interleukin-12 family signaling R-HSA-447115 9.198774e-05 4.036 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.181184e-04 3.928 0 0
IGF1R signaling cascade R-HSA-2428924 1.441703e-04 3.841 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 1.552380e-04 3.809 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.552380e-04 3.809 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.797898e-04 3.745 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 2.607067e-04 3.584 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 2.528580e-04 3.597 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 3.369437e-04 3.472 0 0
Signaling by ALK in cancer R-HSA-9700206 3.369437e-04 3.472 0 0
Interleukin-12 signaling R-HSA-9020591 3.271564e-04 3.485 0 0
Signal attenuation R-HSA-74749 4.026864e-04 3.395 0 0
CASP4 inflammasome assembly R-HSA-9948001 4.026864e-04 3.395 0 0
Immune System R-HSA-168256 4.535884e-04 3.343 1 0
TP53 Regulates Metabolic Genes R-HSA-5628897 5.180841e-04 3.286 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 7.332525e-04 3.135 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 7.332525e-04 3.135 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 6.665745e-04 3.176 0 0
Translation initiation complex formation R-HSA-72649 6.033155e-04 3.219 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 6.950802e-04 3.158 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 6.005054e-04 3.221 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 7.332525e-04 3.135 0 0
Pervasive developmental disorders R-HSA-9005895 7.332525e-04 3.135 0 0
Disorders of Nervous System Development R-HSA-9697154 7.332525e-04 3.135 0 0
RAF/MAP kinase cascade R-HSA-5673001 5.699901e-04 3.244 0 0
MAPK family signaling cascades R-HSA-5683057 6.776212e-04 3.169 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 7.969062e-04 3.099 0 0
Interleukin-6 signaling R-HSA-1059683 8.726284e-04 3.059 0 0
Microbial factors inhibit CASP4 activity R-HSA-9956593 8.726284e-04 3.059 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 8.138878e-04 3.089 0 0
Non-canonical inflammasome activation R-HSA-9686114 1.027758e-03 2.988 0 0
Disorders of Developmental Biology R-HSA-9675151 1.594092e-03 2.797 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.594092e-03 2.797 0 0
Signaling by ALK R-HSA-201556 1.635592e-03 2.786 0 0
MTF1 activates gene expression R-HSA-5660489 1.979852e-03 2.703 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.029166e-03 2.693 0 0
IRS activation R-HSA-74713 2.675892e-03 2.573 0 0
Apoptotic execution phase R-HSA-75153 2.907433e-03 2.536 0 0
Mitochondrial biogenesis R-HSA-1592230 3.120448e-03 2.506 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 3.232646e-03 2.490 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 3.470542e-03 2.460 0 0
Developmental Cell Lineages R-HSA-9734767 3.770867e-03 2.424 0 0
Deadenylation of mRNA R-HSA-429947 4.331713e-03 2.363 0 0
Interleukin-6 family signaling R-HSA-6783589 4.331713e-03 2.363 0 0
Smooth Muscle Contraction R-HSA-445355 4.468877e-03 2.350 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 5.347060e-03 2.272 0 0
SOS-mediated signalling R-HSA-112412 5.347060e-03 2.272 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 5.347060e-03 2.272 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 5.282987e-03 2.277 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 6.112178e-03 2.214 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 6.424704e-03 2.192 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 6.424704e-03 2.192 0 0
Signaling by ERBB2 R-HSA-1227986 6.515091e-03 2.186 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 6.424704e-03 2.192 0 0
Lipophagy R-HSA-9613354 7.592515e-03 2.120 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 8.848464e-03 2.053 0 0
PI3K/AKT activation R-HSA-198203 8.848464e-03 2.053 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 8.848464e-03 2.053 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 8.873033e-03 2.052 0 0
Signaling by Leptin R-HSA-2586552 8.848464e-03 2.053 0 0
Signaling by Nuclear Receptors R-HSA-9006931 8.889478e-03 2.051 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 1.019056e-02 1.992 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 1.015056e-02 1.994 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 9.997186e-03 2.000 0 0
RAF activation R-HSA-5673000 1.015056e-02 1.994 0 0
Interleukin-2 signaling R-HSA-9020558 1.019056e-02 1.992 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 9.997186e-03 2.000 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.019056e-02 1.992 0 0
Signaling by NTRKs R-HSA-166520 9.535059e-03 2.021 0 0
RET signaling R-HSA-8853659 1.152951e-02 1.938 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 1.161683e-02 1.935 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.161683e-02 1.935 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.179161e-02 1.928 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.179161e-02 1.928 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.312535e-02 1.882 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.370909e-02 1.863 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.370909e-02 1.863 0 0
Interleukin-15 signaling R-HSA-8983432 1.312535e-02 1.882 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.225745e-02 1.912 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.278937e-02 1.893 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 1.383954e-02 1.859 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.454915e-02 1.837 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 1.471423e-02 1.832 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 1.542869e-02 1.812 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.628692e-02 1.788 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 1.638158e-02 1.786 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.669983e-02 1.777 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.701887e-02 1.769 0 0
Cytoprotection by HMOX1 R-HSA-9707564 1.731294e-02 1.762 0 0
Erythropoietin activates RAS R-HSA-9027284 1.812558e-02 1.742 0 0
Post NMDA receptor activation events R-HSA-438064 2.058857e-02 1.686 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 2.085940e-02 1.681 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.901989e-02 1.721 0 0
Signaling downstream of RAS mutants R-HSA-9649948 2.097425e-02 1.678 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 2.097425e-02 1.678 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 2.097425e-02 1.678 0 0
Signaling by RAS mutants R-HSA-6802949 2.097425e-02 1.678 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.131892e-02 1.671 0 0
Response to metal ions R-HSA-5660526 2.183630e-02 1.661 0 0
GPER1 signaling R-HSA-9634597 2.303477e-02 1.638 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 2.303477e-02 1.638 0 0
Signaling by Hippo R-HSA-2028269 2.379949e-02 1.623 0 0
Uptake and function of anthrax toxins R-HSA-5210891 2.379949e-02 1.623 1 1
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.583227e-02 1.588 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.583227e-02 1.588 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 2.657558e-02 1.576 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 3.171907e-02 1.499 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 3.233131e-02 1.490 0 0
mRNA 3'-end processing R-HSA-72187 2.747420e-02 1.561 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 3.009983e-02 1.521 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 3.233131e-02 1.490 0 0
Formation of definitive endoderm R-HSA-9823730 3.009983e-02 1.521 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.992137e-02 1.524 0 0
RNA Polymerase II Transcription R-HSA-73857 2.795088e-02 1.554 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 3.350563e-02 1.475 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 4.206820e-02 1.376 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 4.206820e-02 1.376 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 4.206820e-02 1.376 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 4.206820e-02 1.376 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 4.206820e-02 1.376 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 4.206820e-02 1.376 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 4.206820e-02 1.376 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 4.206820e-02 1.376 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 4.206820e-02 1.376 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 4.206820e-02 1.376 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 4.206820e-02 1.376 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 3.462577e-02 1.461 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 3.462577e-02 1.461 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 3.462577e-02 1.461 0 0
Interleukin receptor SHC signaling R-HSA-912526 3.939730e-02 1.405 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 4.187129e-02 1.378 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 4.187129e-02 1.378 0 0
Regulation of PTEN gene transcription R-HSA-8943724 3.761756e-02 1.425 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 3.443917e-02 1.463 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 3.900262e-02 1.409 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 3.939730e-02 1.405 0 0
Notch-HLH transcription pathway R-HSA-350054 3.698162e-02 1.432 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 3.625832e-02 1.441 0 0
Response of endothelial cells to shear stress R-HSA-9860931 3.635140e-02 1.439 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 3.900262e-02 1.409 0 0
Complex III assembly R-HSA-9865881 4.187129e-02 1.378 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 4.041337e-02 1.393 0 0
PI Metabolism R-HSA-1483255 3.443917e-02 1.463 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 3.908464e-02 1.408 0 0
Growth hormone receptor signaling R-HSA-982772 3.939730e-02 1.405 0 0
Axon guidance R-HSA-422475 4.302128e-02 1.366 0 0
Insulin receptor signalling cascade R-HSA-74751 4.331148e-02 1.363 0 0
Long-term potentiation R-HSA-9620244 4.440208e-02 1.353 0 0
Sema4D in semaphorin signaling R-HSA-400685 4.440208e-02 1.353 0 0
Interleukin-7 signaling R-HSA-1266695 4.440208e-02 1.353 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 4.479859e-02 1.349 0 0
Inositol phosphate metabolism R-HSA-1483249 4.570306e-02 1.340 0 0
Cellular responses to stimuli R-HSA-8953897 4.613894e-02 1.336 1 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.698819e-02 1.328 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 4.794715e-02 1.319 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 4.962816e-02 1.304 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 4.962816e-02 1.304 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 5.099737e-02 1.292 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 5.230735e-02 1.281 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 5.232055e-02 1.281 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 6.243768e-02 1.205 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 6.243768e-02 1.205 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 7.246034e-02 1.140 0 0
Signaling by Erythropoietin R-HSA-9006335 5.506397e-02 1.259 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 5.506397e-02 1.259 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 5.785703e-02 1.238 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 5.785703e-02 1.238 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 7.246034e-02 1.140 0 0
DAP12 signaling R-HSA-2424491 5.785703e-02 1.238 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 5.785703e-02 1.238 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 6.243768e-02 1.205 0 0
Pyrophosphate hydrolysis R-HSA-71737 7.246034e-02 1.140 0 0
Signaling by VEGF R-HSA-194138 6.532963e-02 1.185 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 5.506397e-02 1.259 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 5.785703e-02 1.238 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 6.652054e-02 1.177 0 0
Signaling by FGFR2 R-HSA-5654738 7.003705e-02 1.155 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 6.136039e-02 1.212 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 6.943010e-02 1.158 0 0
ESR-mediated signaling R-HSA-8939211 6.024179e-02 1.220 0 0
Nervous system development R-HSA-9675108 6.194392e-02 1.208 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 7.190697e-02 1.143 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 6.818963e-02 1.166 0 0
Gene expression (Transcription) R-HSA-74160 5.441066e-02 1.264 0 0
Nuclear import of Rev protein R-HSA-180746 7.252007e-02 1.140 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 7.252007e-02 1.140 0 0
Developmental Biology R-HSA-1266738 7.397300e-02 1.131 0 0
Organelle biogenesis and maintenance R-HSA-1852241 7.556290e-02 1.122 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 7.558319e-02 1.122 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 7.558319e-02 1.122 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 7.558319e-02 1.122 0 0
RUNX2 regulates bone development R-HSA-8941326 7.868690e-02 1.104 0 0
Oncogenic MAPK signaling R-HSA-6802957 7.960757e-02 1.099 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 8.237647e-02 1.084 0 0
Phosphorylation of Emi1 R-HSA-176417 8.237647e-02 1.084 0 0
Erythropoietin activates STAT5 R-HSA-9027283 9.218720e-02 1.035 0 0
Regulation of PTEN localization R-HSA-8948747 1.018936e-01 0.992 0 0
IFNG signaling activates MAPKs R-HSA-9732724 1.018936e-01 0.992 0 0
Recycling of eIF2:GDP R-HSA-72731 1.018936e-01 0.992 0 0
ALKBH3 mediated reversal of alkylation damage R-HSA-112126 1.114969e-01 0.953 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 1.303982e-01 0.885 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 1.303982e-01 0.885 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 1.303982e-01 0.885 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.396983e-01 0.855 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 1.580031e-01 0.801 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 1.759205e-01 0.755 0 0
SHC1 events in EGFR signaling R-HSA-180336 1.847366e-01 0.733 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 1.847366e-01 0.733 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 1.934588e-01 0.713 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.934588e-01 0.713 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 1.934588e-01 0.713 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 2.020883e-01 0.694 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 2.020883e-01 0.694 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 2.106260e-01 0.676 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 2.106260e-01 0.676 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 2.356979e-01 0.628 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 1.151764e-01 0.939 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.151764e-01 0.939 0 0
Amplification of signal from the kinetochores R-HSA-141424 8.158685e-02 1.088 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 8.158685e-02 1.088 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 2.047768e-01 0.689 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.662884e-01 0.779 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.209980e-01 0.917 0 0
MAP2K and MAPK activation R-HSA-5674135 9.809548e-02 1.008 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 1.625069e-01 0.789 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.114969e-01 0.953 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.303982e-01 0.885 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 1.209980e-01 0.917 0 0
PTEN Regulation R-HSA-6807070 8.867795e-02 1.052 0 0
HCMV Early Events R-HSA-9609690 2.016993e-01 0.695 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 8.501129e-02 1.071 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 8.822962e-02 1.054 0 0
FCERI mediated MAPK activation R-HSA-2871796 1.497527e-01 0.825 1 1
Interactions of Rev with host cellular proteins R-HSA-177243 9.148384e-02 1.039 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 1.114969e-01 0.953 0 0
Calcineurin activates NFAT R-HSA-2025928 1.209980e-01 0.917 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 1.488996e-01 0.827 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 1.759205e-01 0.755 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 2.106260e-01 0.676 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 9.477283e-02 1.023 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.847366e-01 0.733 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.182881e-01 0.927 0 0
Interleukin-2 family signaling R-HSA-451927 9.148384e-02 1.039 0 0
Signaling by Insulin receptor R-HSA-74752 9.816523e-02 1.008 0 0
Adipogenesis R-HSA-9843745 2.107994e-01 0.676 0 0
Cam-PDE 1 activation R-HSA-111957 8.237647e-02 1.084 0 0
Ionotropic activity of kainate receptors R-HSA-451306 1.396983e-01 0.855 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.117013e-01 0.952 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.184654e-02 1.037 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 1.553213e-01 0.809 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 1.580031e-01 0.801 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 2.020883e-01 0.694 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 2.400189e-01 0.620 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 2.020883e-01 0.694 0 0
IRS-mediated signalling R-HSA-112399 1.550074e-01 0.810 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 2.172564e-01 0.663 1 0
Activated NTRK3 signals through PI3K R-HSA-9603381 1.018936e-01 0.992 0 0
Interleukin-27 signaling R-HSA-9020956 1.303982e-01 0.885 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 1.488996e-01 0.827 0 0
MET activates RAS signaling R-HSA-8851805 1.580031e-01 0.801 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 2.020883e-01 0.694 0 0
Heme signaling R-HSA-9707616 1.738868e-01 0.760 0 0
Interleukin-35 Signalling R-HSA-8984722 1.580031e-01 0.801 0 0
DNA Damage Reversal R-HSA-73942 1.847366e-01 0.733 0 0
Synaptic adhesion-like molecules R-HSA-8849932 2.190729e-01 0.659 0 0
Leishmania phagocytosis R-HSA-9664417 2.388636e-01 0.622 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 2.388636e-01 0.622 0 0
Parasite infection R-HSA-9664407 2.388636e-01 0.622 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.190729e-01 0.659 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.091627e-01 0.962 0 0
Mitochondrial protein import R-HSA-1268020 1.738868e-01 0.760 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 8.237647e-02 1.084 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 8.237647e-02 1.084 0 0
MAPK1 (ERK2) activation R-HSA-112411 1.209980e-01 0.917 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 1.488996e-01 0.827 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 1.488996e-01 0.827 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 1.670097e-01 0.777 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 2.356979e-01 0.628 0 0
DAP12 interactions R-HSA-2172127 1.082547e-01 0.966 0 0
Mitotic Prometaphase R-HSA-68877 1.951390e-01 0.710 0 0
Respiratory electron transport R-HSA-611105 1.634341e-01 0.787 0 0
STING mediated induction of host immune responses R-HSA-1834941 2.274299e-01 0.643 0 0
Translation R-HSA-72766 2.116859e-01 0.674 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.782236e-01 0.749 0 0
Negative regulation of MAPK pathway R-HSA-5675221 9.809548e-02 1.008 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 1.670097e-01 0.777 0 0
tRNA processing in the nucleus R-HSA-6784531 1.738868e-01 0.760 0 0
VEGF ligand-receptor interactions R-HSA-194313 8.237647e-02 1.084 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.114969e-01 0.953 0 0
MAPK3 (ERK1) activation R-HSA-110056 1.303982e-01 0.885 0 0
Sodium/Calcium exchangers R-HSA-425561 1.488996e-01 0.827 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.580031e-01 0.801 0 0
PKA activation R-HSA-163615 2.190729e-01 0.659 0 0
Muscle contraction R-HSA-397014 2.400189e-01 0.620 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.209980e-01 0.917 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.106260e-01 0.676 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.106260e-01 0.676 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 2.135729e-01 0.670 0 0
Kinesins R-HSA-983189 1.662884e-01 0.779 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.014507e-01 0.994 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 2.125962e-01 0.672 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.625069e-01 0.789 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 8.237647e-02 1.084 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.151764e-01 0.939 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 1.365697e-01 0.865 0 0
HDACs deacetylate histones R-HSA-3214815 1.475736e-01 0.831 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 2.125962e-01 0.672 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.422641e-01 0.847 0 0
Signaling by ERBB4 R-HSA-1236394 2.204443e-01 0.657 0 0
Signal transduction by L1 R-HSA-445144 2.356979e-01 0.628 0 0
MTOR signalling R-HSA-165159 1.014507e-01 0.994 0 0
Cellular response to mitochondrial stress R-HSA-9840373 1.209980e-01 0.917 0 0
Negative regulation of FLT3 R-HSA-9706369 1.934588e-01 0.713 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 8.182999e-02 1.087 0 0
Creatine metabolism R-HSA-71288 2.356979e-01 0.628 0 0
PI3K Cascade R-HSA-109704 1.293415e-01 0.888 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.916274e-01 0.718 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.916274e-01 0.718 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.916274e-01 0.718 0 0
Rap1 signalling R-HSA-392517 2.274299e-01 0.643 0 0
Activation of HOX genes during differentiation R-HSA-5619507 1.300780e-01 0.886 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 1.300780e-01 0.886 0 0
Leishmania infection R-HSA-9658195 2.241120e-01 0.650 0 0
Parasitic Infection Pathways R-HSA-9824443 2.241120e-01 0.650 0 0
Signaling by FGFR R-HSA-190236 1.136902e-01 0.944 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.835536e-01 0.736 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 1.759205e-01 0.755 0 0
Regulation of KIT signaling R-HSA-1433559 1.759205e-01 0.755 0 0
Choline catabolism R-HSA-6798163 2.106260e-01 0.676 0 0
Protein ubiquitination R-HSA-8852135 2.243776e-01 0.649 0 0
Ub-specific processing proteases R-HSA-5689880 1.533175e-01 0.814 0 0
Protein methylation R-HSA-8876725 1.847366e-01 0.733 0 0
Selective autophagy R-HSA-9663891 8.765103e-02 1.057 0 0
Deubiquitination R-HSA-5688426 1.756367e-01 0.755 0 0
Signal regulatory protein family interactions R-HSA-391160 1.759205e-01 0.755 0 0
Signaling by NOTCH4 R-HSA-9013694 2.204443e-01 0.657 0 0
Signaling by ROBO receptors R-HSA-376176 2.172564e-01 0.663 0 0
Signaling by FGFR4 R-HSA-5654743 1.048375e-01 0.979 0 0
Semaphorin interactions R-HSA-373755 1.777072e-01 0.750 0 0
Disease R-HSA-1643685 2.196955e-01 0.658 1 0
Stimuli-sensing channels R-HSA-2672351 1.397967e-01 0.855 0 0
Signaling by FGFR3 R-HSA-5654741 1.117013e-01 0.952 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 1.847366e-01 0.733 0 0
Ephrin signaling R-HSA-3928664 2.190729e-01 0.659 0 0
EPH-Ephrin signaling R-HSA-2682334 9.816523e-02 1.008 0 0
Signaling by FGFR1 R-HSA-5654736 1.512813e-01 0.820 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 2.086826e-01 0.681 0 0
Signaling by PTK6 R-HSA-8848021 1.777072e-01 0.750 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.777072e-01 0.750 0 0
Tie2 Signaling R-HSA-210993 2.190729e-01 0.659 0 0
Integration of energy metabolism R-HSA-163685 2.275545e-01 0.643 0 0
Interferon Signaling R-HSA-913531 1.464816e-01 0.834 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.349066e-01 0.870 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.257624e-01 0.900 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 1.587511e-01 0.799 0 0
Dissolution of Fibrin Clot R-HSA-75205 1.396983e-01 0.855 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 1.670097e-01 0.777 0 0
tRNA Aminoacylation R-HSA-379724 1.662884e-01 0.779 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.662884e-01 0.779 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.662884e-01 0.779 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.662884e-01 0.779 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.662884e-01 0.779 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 1.777072e-01 0.750 0 0
Signaling by TGFB family members R-HSA-9006936 1.263655e-01 0.898 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 2.106260e-01 0.676 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 1.929673e-01 0.715 0 0
Generic Transcription Pathway R-HSA-212436 8.006718e-02 1.097 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.543667e-01 0.811 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 1.759205e-01 0.755 0 0
Integrin cell surface interactions R-HSA-216083 2.362078e-01 0.627 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 2.274299e-01 0.643 0 0
Cellular response to chemical stress R-HSA-9711123 9.185239e-02 1.037 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 1.365697e-01 0.865 1 0
Signaling by NOTCH R-HSA-157118 1.497431e-01 0.825 0 0
Unfolded Protein Response (UPR) R-HSA-381119 2.360269e-01 0.627 0 0
Apoptosis R-HSA-109581 1.300842e-01 0.886 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.662884e-01 0.779 0 0
Signaling by NOTCH1 R-HSA-1980143 2.283164e-01 0.641 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.573349e-01 0.803 0 0
Programmed Cell Death R-HSA-5357801 2.240228e-01 0.650 0 0
Macroautophagy R-HSA-1632852 2.417061e-01 0.617 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 2.438780e-01 0.613 1 1
Signalling to RAS R-HSA-167044 2.438780e-01 0.613 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 2.438780e-01 0.613 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 2.438780e-01 0.613 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 2.438780e-01 0.613 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 2.438780e-01 0.613 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.441143e-01 0.612 0 0
Mitotic Anaphase R-HSA-68882 2.492779e-01 0.603 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 2.516049e-01 0.599 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 2.519711e-01 0.599 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 2.519711e-01 0.599 0 0
Adherens junctions interactions R-HSA-418990 2.539365e-01 0.595 0 0
FGFR2 alternative splicing R-HSA-6803529 2.599780e-01 0.585 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 2.599780e-01 0.585 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 2.599780e-01 0.585 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 2.599780e-01 0.585 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 2.678831e-01 0.572 0 0
Termination of O-glycan biosynthesis R-HSA-977068 2.678997e-01 0.572 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 2.678997e-01 0.572 0 0
Carnitine shuttle R-HSA-200425 2.678997e-01 0.572 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.718467e-01 0.566 0 0
XBP1(S) activates chaperone genes R-HSA-381038 2.718467e-01 0.566 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 2.757371e-01 0.560 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 2.761988e-01 0.559 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.820015e-01 0.550 0 0
Death Receptor Signaling R-HSA-73887 2.820015e-01 0.550 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 2.834910e-01 0.547 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 2.834910e-01 0.547 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 2.834910e-01 0.547 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 2.834910e-01 0.547 0 0
Autophagy R-HSA-9612973 2.878154e-01 0.541 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 2.911625e-01 0.536 0 0
Myogenesis R-HSA-525793 2.911625e-01 0.536 0 0
Signaling by EGFR in Cancer R-HSA-1643713 2.911625e-01 0.536 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 2.911625e-01 0.536 0 0
TRP channels R-HSA-3295583 2.911625e-01 0.536 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 2.911625e-01 0.536 0 0
Cell-Cell communication R-HSA-1500931 2.946297e-01 0.531 0 0
IRE1alpha activates chaperones R-HSA-381070 2.956003e-01 0.529 0 0
Cristae formation R-HSA-8949613 2.987522e-01 0.525 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 2.987522e-01 0.525 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 2.987522e-01 0.525 0 0
Regulation of TP53 Activity R-HSA-5633007 2.994703e-01 0.524 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 3.062612e-01 0.514 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 3.062612e-01 0.514 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 3.062612e-01 0.514 0 0
Separation of Sister Chromatids R-HSA-2467813 3.111514e-01 0.507 0 0
DARPP-32 events R-HSA-180024 3.136902e-01 0.503 0 0
Platelet calcium homeostasis R-HSA-418360 3.136902e-01 0.503 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 3.136902e-01 0.503 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 3.192431e-01 0.496 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 3.210401e-01 0.493 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 3.210401e-01 0.493 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 3.210401e-01 0.493 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 3.210401e-01 0.493 0 0
Interleukin-37 signaling R-HSA-9008059 3.210401e-01 0.493 0 0
Cellular responses to stress R-HSA-2262752 3.259982e-01 0.487 1 0
Downstream signal transduction R-HSA-186763 3.283117e-01 0.484 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 3.283117e-01 0.484 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 3.283117e-01 0.484 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 3.283117e-01 0.484 0 0
HCMV Infection R-HSA-9609646 3.303394e-01 0.481 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 3.309981e-01 0.480 0 0
Cell-cell junction organization R-HSA-421270 3.327625e-01 0.478 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 3.345463e-01 0.476 0 0
G alpha (s) signalling events R-HSA-418555 3.345463e-01 0.476 0 0
Diseases of mitotic cell cycle R-HSA-9675126 3.355060e-01 0.474 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 3.355060e-01 0.474 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 3.403938e-01 0.468 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 3.403938e-01 0.468 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 3.426236e-01 0.465 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 3.426236e-01 0.465 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 3.426236e-01 0.465 0 0
Nuclear RNA decay R-HSA-9930044 3.426236e-01 0.465 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 3.426236e-01 0.465 0 0
Integrin signaling R-HSA-354192 3.426236e-01 0.465 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 3.426236e-01 0.465 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 3.462381e-01 0.461 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 3.471316e-01 0.460 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 3.496654e-01 0.456 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 3.496654e-01 0.456 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 3.496654e-01 0.456 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 3.496654e-01 0.456 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 3.496654e-01 0.456 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 3.496654e-01 0.456 0 0
Heme degradation R-HSA-189483 3.496654e-01 0.456 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 3.504605e-01 0.455 0 0
eNOS activation R-HSA-203615 3.566322e-01 0.448 0 0
Mitophagy R-HSA-5205647 3.566322e-01 0.448 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 3.566322e-01 0.448 0 0
Influenza Infection R-HSA-168255 3.579124e-01 0.446 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 3.581933e-01 0.446 1 0
Adaptive Immune System R-HSA-1280218 3.607252e-01 0.443 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 3.635247e-01 0.439 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 3.635247e-01 0.439 0 0
PERK regulates gene expression R-HSA-381042 3.635247e-01 0.439 0 0
Signalling to ERKs R-HSA-187687 3.635247e-01 0.439 0 0
Transferrin endocytosis and recycling R-HSA-917977 3.635247e-01 0.439 0 0
SARS-CoV-2 Infection R-HSA-9694516 3.640972e-01 0.439 0 0
Gene Silencing by RNA R-HSA-211000 3.658928e-01 0.437 0 0
CaM pathway R-HSA-111997 3.703439e-01 0.431 0 0
Calmodulin induced events R-HSA-111933 3.703439e-01 0.431 0 0
GPVI-mediated activation cascade R-HSA-114604 3.703439e-01 0.431 0 0
Regulation of TP53 Degradation R-HSA-6804757 3.703439e-01 0.431 0 0
Voltage gated Potassium channels R-HSA-1296072 3.770904e-01 0.424 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 3.770904e-01 0.424 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 3.770904e-01 0.424 0 0
Ovarian tumor domain proteases R-HSA-5689896 3.770904e-01 0.424 0 0
Lysine catabolism R-HSA-71064 3.770904e-01 0.424 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 3.773755e-01 0.423 1 0
MyD88-independent TLR4 cascade R-HSA-166166 3.773755e-01 0.423 1 0
TCR signaling R-HSA-202403 3.773755e-01 0.423 0 0
Innate Immune System R-HSA-168249 3.788693e-01 0.422 1 0
Infectious disease R-HSA-5663205 3.809601e-01 0.419 1 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 3.837651e-01 0.416 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 3.849833e-01 0.415 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 3.849833e-01 0.415 0 0
Ion channel transport R-HSA-983712 3.869581e-01 0.412 0 0
Platelet activation, signaling and aggregation R-HSA-76002 3.885613e-01 0.411 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 3.903686e-01 0.409 0 0
RAS processing R-HSA-9648002 3.903686e-01 0.409 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 3.903686e-01 0.409 0 0
Pentose phosphate pathway R-HSA-71336 3.903686e-01 0.409 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 3.903686e-01 0.409 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 3.969018e-01 0.401 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 3.969018e-01 0.401 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 3.969018e-01 0.401 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 3.969018e-01 0.401 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 3.969018e-01 0.401 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 3.969018e-01 0.401 0 0
Generation of second messenger molecules R-HSA-202433 3.969018e-01 0.401 0 0
Glycogen metabolism R-HSA-8982491 3.969018e-01 0.401 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 3.969018e-01 0.401 0 0
Cell junction organization R-HSA-446728 3.982324e-01 0.400 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 4.033654e-01 0.394 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 4.033654e-01 0.394 0 0
Maturation of spike protein R-HSA-9694548 4.033654e-01 0.394 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 4.033654e-01 0.394 0 0
FLT3 Signaling R-HSA-9607240 4.033654e-01 0.394 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 4.071128e-01 0.390 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 4.097601e-01 0.387 0 0
Glucose metabolism R-HSA-70326 4.112843e-01 0.386 0 0
Ca-dependent events R-HSA-111996 4.160866e-01 0.381 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 4.160866e-01 0.381 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.185444e-01 0.378 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 4.186990e-01 0.378 0 0
Signaling by SCF-KIT R-HSA-1433557 4.223458e-01 0.374 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 4.260665e-01 0.371 0 0
Infection with Enterobacteria R-HSA-9640148 4.270716e-01 0.369 0 0
G1 Phase R-HSA-69236 4.285382e-01 0.368 0 0
Cyclin D associated events in G1 R-HSA-69231 4.285382e-01 0.368 0 0
Membrane Trafficking R-HSA-199991 4.297457e-01 0.367 0 0
MHC class II antigen presentation R-HSA-2132295 4.333855e-01 0.363 0 0
DAG and IP3 signaling R-HSA-1489509 4.346646e-01 0.362 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 4.346646e-01 0.362 0 0
M Phase R-HSA-68886 4.360713e-01 0.360 0 0
Formation of the cornified envelope R-HSA-6809371 4.370265e-01 0.359 0 0
Host Interactions of HIV factors R-HSA-162909 4.370265e-01 0.359 0 0
Phospholipid metabolism R-HSA-1483257 4.390037e-01 0.358 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 4.407257e-01 0.356 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 4.407257e-01 0.356 0 0
Regulation of TNFR1 signaling R-HSA-5357905 4.407257e-01 0.356 0 0
Cell Cycle, Mitotic R-HSA-69278 4.436753e-01 0.353 0 0
Signaling by WNT R-HSA-195721 4.461246e-01 0.351 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 4.467222e-01 0.350 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 4.478731e-01 0.349 0 0
Gluconeogenesis R-HSA-70263 4.526548e-01 0.344 0 0
NGF-stimulated transcription R-HSA-9031628 4.526548e-01 0.344 0 0
Metal ion SLC transporters R-HSA-425410 4.526548e-01 0.344 0 0
Bacterial Infection Pathways R-HSA-9824439 4.528134e-01 0.344 1 0
Degradation of CDH1 R-HSA-9766229 4.585241e-01 0.339 0 0
Azathioprine ADME R-HSA-9748787 4.643309e-01 0.333 0 0
Complex IV assembly R-HSA-9864848 4.700757e-01 0.328 0 0
The phototransduction cascade R-HSA-2514856 4.700757e-01 0.328 0 0
Circadian clock R-HSA-9909396 4.727204e-01 0.325 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 4.757593e-01 0.323 0 0
Neurexins and neuroligins R-HSA-6794361 4.757593e-01 0.323 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 4.757593e-01 0.323 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 4.757593e-01 0.323 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 4.813822e-01 0.318 0 0
Regulation of PTEN stability and activity R-HSA-8948751 4.813822e-01 0.318 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 4.813822e-01 0.318 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 4.813822e-01 0.318 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 4.869452e-01 0.313 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 4.869452e-01 0.313 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 4.900548e-01 0.310 0 0
Estrogen-dependent gene expression R-HSA-9018519 4.900548e-01 0.310 0 0
Signaling by NOTCH3 R-HSA-9012852 4.924489e-01 0.308 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 4.935062e-01 0.307 0 0
Ion homeostasis R-HSA-5578775 4.978938e-01 0.303 0 0
NRAGE signals death through JNK R-HSA-193648 4.978938e-01 0.303 0 0
Signaling by EGFR R-HSA-177929 4.978938e-01 0.303 0 0
TNF signaling R-HSA-75893 4.978938e-01 0.303 0 0
SARS-CoV-2-host interactions R-HSA-9705683 4.988766e-01 0.302 0 0
Regulation of CDH1 Function R-HSA-9764561 5.032807e-01 0.298 0 0
Nuclear Envelope Breakdown R-HSA-2980766 5.032807e-01 0.298 0 0
Dectin-2 family R-HSA-5621480 5.032807e-01 0.298 0 0
Transmission across Chemical Synapses R-HSA-112315 5.042479e-01 0.297 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 5.086102e-01 0.294 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 5.086102e-01 0.294 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 5.137179e-01 0.289 0 0
Late Phase of HIV Life Cycle R-HSA-162599 5.137179e-01 0.289 0 0
snRNP Assembly R-HSA-191859 5.138827e-01 0.289 0 0
Metabolism of non-coding RNA R-HSA-194441 5.138827e-01 0.289 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 5.138827e-01 0.289 0 0
PLC beta mediated events R-HSA-112043 5.242597e-01 0.280 0 0
Viral Messenger RNA Synthesis R-HSA-168325 5.242597e-01 0.280 0 0
MAP kinase activation R-HSA-450294 5.242597e-01 0.280 1 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 5.293653e-01 0.276 0 0
Signaling by PDGF R-HSA-186797 5.293653e-01 0.276 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 5.334208e-01 0.273 1 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 5.344164e-01 0.272 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 5.344164e-01 0.272 0 0
Complex I biogenesis R-HSA-6799198 5.344164e-01 0.272 0 0
Gastrulation R-HSA-9758941 5.366515e-01 0.270 0 0
Ion transport by P-type ATPases R-HSA-936837 5.394136e-01 0.268 0 0
MITF-M-dependent gene expression R-HSA-9856651 5.398670e-01 0.268 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 5.430672e-01 0.265 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 5.462520e-01 0.263 0 0
Interleukin-1 family signaling R-HSA-446652 5.462520e-01 0.263 0 0
AURKA Activation by TPX2 R-HSA-8854518 5.492487e-01 0.260 0 0
Protein localization R-HSA-9609507 5.494214e-01 0.260 0 0
G-protein mediated events R-HSA-112040 5.540876e-01 0.256 0 0
DNA Double Strand Break Response R-HSA-5693606 5.540876e-01 0.256 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 5.557138e-01 0.255 0 0
PPARA activates gene expression R-HSA-1989781 5.557138e-01 0.255 0 0
O-linked glycosylation of mucins R-HSA-913709 5.588749e-01 0.253 0 0
HCMV Late Events R-HSA-9610379 5.619441e-01 0.250 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 5.619441e-01 0.250 0 0
HIV Life Cycle R-HSA-162587 5.619441e-01 0.250 0 0
Cellular response to starvation R-HSA-9711097 5.650360e-01 0.248 0 0
Interferon gamma signaling R-HSA-877300 5.681123e-01 0.246 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 5.682966e-01 0.245 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 5.682966e-01 0.245 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 5.682966e-01 0.245 0 0
Interleukin-17 signaling R-HSA-448424 5.682966e-01 0.245 1 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 5.729322e-01 0.242 0 0
Regulation of mitotic cell cycle R-HSA-453276 5.729322e-01 0.242 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 5.729322e-01 0.242 0 0
Metabolism of cofactors R-HSA-8978934 5.729322e-01 0.242 0 0
Hedgehog 'on' state R-HSA-5632684 5.729322e-01 0.242 0 0
Metabolism of porphyrins R-HSA-189445 5.729322e-01 0.242 0 0
Cell Cycle Checkpoints R-HSA-69620 5.757462e-01 0.240 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 5.775183e-01 0.238 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 5.775183e-01 0.238 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 5.820555e-01 0.235 0 0
Ca2+ pathway R-HSA-4086398 5.820555e-01 0.235 0 0
Switching of origins to a post-replicative state R-HSA-69052 5.820555e-01 0.235 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 5.820555e-01 0.235 0 0
Neutrophil degranulation R-HSA-6798695 5.858427e-01 0.232 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 5.865441e-01 0.232 0 0
SARS-CoV Infections R-HSA-9679506 5.874193e-01 0.231 0 0
Centrosome maturation R-HSA-380287 5.909849e-01 0.228 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 5.909849e-01 0.228 0 0
Iron uptake and transport R-HSA-917937 5.909849e-01 0.228 0 0
UCH proteinases R-HSA-5689603 5.953782e-01 0.225 0 0
Translation of Structural Proteins R-HSA-9694635 5.997246e-01 0.222 0 0
tRNA processing R-HSA-72306 6.038057e-01 0.219 0 0
Nuclear Receptor transcription pathway R-HSA-383280 6.040246e-01 0.219 0 0
PCP/CE pathway R-HSA-4086400 6.040246e-01 0.219 0 0
G alpha (12/13) signalling events R-HSA-416482 6.040246e-01 0.219 0 0
Neuronal System R-HSA-112316 6.060194e-01 0.218 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 6.095348e-01 0.215 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 6.123758e-01 0.213 0 0
Leishmania parasite growth and survival R-HSA-9664433 6.123758e-01 0.213 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 6.124873e-01 0.213 0 0
Signaling by MET R-HSA-6806834 6.124873e-01 0.213 0 0
PKR-mediated signaling R-HSA-9833482 6.124873e-01 0.213 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 6.207701e-01 0.207 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 6.288769e-01 0.201 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 6.288769e-01 0.201 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 6.288769e-01 0.201 0 0
Cellular Senescence R-HSA-2559583 6.318240e-01 0.199 1 0
Protein-protein interactions at synapses R-HSA-6794362 6.328655e-01 0.199 0 0
Hemostasis R-HSA-109582 6.386947e-01 0.195 0 0
Chaperonin-mediated protein folding R-HSA-390466 6.445772e-01 0.191 0 0
G2/M Transition R-HSA-69275 6.478855e-01 0.189 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 6.483980e-01 0.188 0 0
Peptide chain elongation R-HSA-156902 6.483980e-01 0.188 0 0
ER-Phagosome pathway R-HSA-1236974 6.521779e-01 0.186 0 0
Mitotic G2-G2/M phases R-HSA-453274 6.531154e-01 0.185 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 6.559174e-01 0.183 0 0
Downstream TCR signaling R-HSA-202424 6.559174e-01 0.183 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 6.596169e-01 0.181 0 0
Toll-like Receptor Cascades R-HSA-168898 6.608447e-01 0.180 1 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 6.632769e-01 0.178 0 0
Eukaryotic Translation Elongation R-HSA-156842 6.668978e-01 0.176 0 0
Protein folding R-HSA-391251 6.668978e-01 0.176 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 6.668978e-01 0.176 0 0
FCGR activation R-HSA-2029481 6.704800e-01 0.174 0 0
Assembly of the pre-replicative complex R-HSA-68867 6.704800e-01 0.174 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 6.704800e-01 0.174 0 0
Vesicle-mediated transport R-HSA-5653656 6.710482e-01 0.173 0 0
Cell Cycle R-HSA-1640170 6.710769e-01 0.173 0 0
Mitochondrial protein degradation R-HSA-9837999 6.740238e-01 0.171 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 6.775298e-01 0.169 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 6.775298e-01 0.169 0 0
Formation of a pool of free 40S subunits R-HSA-72689 6.809982e-01 0.167 0 0
Eukaryotic Translation Termination R-HSA-72764 6.809982e-01 0.167 0 0
Co-inhibition by PD-1 R-HSA-389948 6.832096e-01 0.165 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 6.844296e-01 0.165 0 0
COPI-mediated anterograde transport R-HSA-6807878 6.844296e-01 0.165 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 6.844296e-01 0.165 0 0
Potassium Channels R-HSA-1296071 6.844296e-01 0.165 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 6.911827e-01 0.160 1 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 6.911827e-01 0.160 1 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 6.911827e-01 0.160 1 0
Viral Infection Pathways R-HSA-9824446 6.952887e-01 0.158 0 0
Glycolysis R-HSA-70171 6.977920e-01 0.156 0 0
ABC-family proteins mediated transport R-HSA-382556 6.977920e-01 0.156 0 0
Keratinization R-HSA-6805567 6.997641e-01 0.155 0 0
Selenocysteine synthesis R-HSA-2408557 7.010437e-01 0.154 0 0
Interleukin-1 signaling R-HSA-9020702 7.010437e-01 0.154 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 7.042607e-01 0.152 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 7.042607e-01 0.152 1 1
Viral mRNA Translation R-HSA-192823 7.074432e-01 0.150 0 0
Opioid Signalling R-HSA-111885 7.105917e-01 0.148 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 7.137065e-01 0.146 0 0
RSV-host interactions R-HSA-9833110 7.137065e-01 0.146 0 0
Epigenetic regulation of gene expression R-HSA-212165 7.151024e-01 0.146 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 7.155996e-01 0.145 0 0
Nucleotide Excision Repair R-HSA-5696398 7.167880e-01 0.145 0 0
Metabolism of steroids R-HSA-8957322 7.169420e-01 0.145 0 0
Platelet homeostasis R-HSA-418346 7.198364e-01 0.143 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 7.228523e-01 0.141 0 0
Synthesis of DNA R-HSA-69239 7.228523e-01 0.141 0 0
Antigen processing-Cross presentation R-HSA-1236975 7.258359e-01 0.139 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.258359e-01 0.139 1 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 7.287875e-01 0.137 1 0
DNA Replication Pre-Initiation R-HSA-69002 7.287875e-01 0.137 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 7.402815e-01 0.131 1 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 7.430785e-01 0.129 0 0
HIV Infection R-HSA-162906 7.451811e-01 0.128 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 7.485829e-01 0.126 1 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 7.491862e-01 0.125 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 7.512910e-01 0.124 0 0
L1CAM interactions R-HSA-373760 7.539701e-01 0.123 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 7.548344e-01 0.122 0 0
Chromatin modifying enzymes R-HSA-3247509 7.589642e-01 0.120 0 0
Homology Directed Repair R-HSA-5693538 7.592425e-01 0.120 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 7.618364e-01 0.118 1 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 7.618364e-01 0.118 1 0
Mitotic Prophase R-HSA-68875 7.644026e-01 0.117 0 0
Cellular response to heat stress R-HSA-3371556 7.669412e-01 0.115 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 7.694527e-01 0.114 1 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 7.694527e-01 0.114 1 0
DNA Repair R-HSA-73894 7.772197e-01 0.109 0 0
Platelet degranulation R-HSA-114608 7.839662e-01 0.106 0 0
Chromatin organization R-HSA-4839726 7.863525e-01 0.104 0 0
Cardiac conduction R-HSA-5576891 7.953642e-01 0.099 0 0
Degradation of the extracellular matrix R-HSA-1474228 7.975710e-01 0.098 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 7.981769e-01 0.098 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 7.997542e-01 0.097 0 0
O-linked glycosylation R-HSA-5173105 8.103237e-01 0.091 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 8.103237e-01 0.091 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.112838e-01 0.091 0 0
Ribosome-associated quality control R-HSA-9948299 8.123701e-01 0.090 0 0
Signaling by Hedgehog R-HSA-5358351 8.123701e-01 0.090 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 8.298272e-01 0.081 0 0
ER to Golgi Anterograde Transport R-HSA-199977 8.316643e-01 0.080 0 0
Visual phototransduction R-HSA-2187338 8.316643e-01 0.080 0 0
S Phase R-HSA-69242 8.334817e-01 0.079 0 0
Metabolism of proteins R-HSA-392499 8.359824e-01 0.078 0 0
Potential therapeutics for SARS R-HSA-9679191 8.370582e-01 0.077 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.371903e-01 0.077 0 0
DNA Replication R-HSA-69306 8.422802e-01 0.075 0 0
DNA Double-Strand Break Repair R-HSA-5693532 8.422802e-01 0.075 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 8.506162e-01 0.070 0 0
Selenoamino acid metabolism R-HSA-2408522 8.600432e-01 0.065 0 0
SLC transporter disorders R-HSA-5619102 8.645324e-01 0.063 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 8.702961e-01 0.060 0 0
TCF dependent signaling in response to WNT R-HSA-201681 8.873963e-01 0.052 0 0
Diseases of glycosylation R-HSA-3781865 8.886148e-01 0.051 0 0
Extracellular matrix organization R-HSA-1474244 8.927530e-01 0.049 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 8.933592e-01 0.049 0 0
Cilium Assembly R-HSA-5617833 8.956554e-01 0.048 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.084364e-01 0.042 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.196802e-01 0.036 0 0
Post-translational protein modification R-HSA-597592 9.217578e-01 0.035 0 0
Drug ADME R-HSA-9748784 9.239222e-01 0.034 0 0
Neddylation R-HSA-8951664 9.263709e-01 0.033 0 0
GPCR downstream signalling R-HSA-388396 9.323021e-01 0.030 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.332568e-01 0.030 0 0
rRNA processing R-HSA-72312 9.346978e-01 0.029 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.381664e-01 0.028 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.445636e-01 0.025 0 0
Fatty acid metabolism R-HSA-8978868 9.458364e-01 0.024 0 0
Signaling by GPCR R-HSA-372790 9.618821e-01 0.017 0 0
Metabolism of lipids R-HSA-556833 9.674923e-01 0.014 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.695540e-01 0.013 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.894331e-01 0.005 0 0
G alpha (i) signalling events R-HSA-418594 9.905370e-01 0.004 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.919814e-01 0.003 0 0
Diseases of metabolism R-HSA-5668914 9.924124e-01 0.003 0 0
Transport of small molecules R-HSA-382551 9.951475e-01 0.002 0 0
Metabolism R-HSA-1430728 9.993429e-01 0.000 0 0
Sensory Perception R-HSA-9709957 9.999992e-01 0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Apoptotic execution phase R-HSA-75153 1.865186e-10 9.729 0 0
Cell Cycle, Mitotic R-HSA-69278 3.859493e-10 9.413 0 0
Cell Cycle R-HSA-1640170 5.051519e-10 9.297 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 2.777748e-08 7.556 0 0
Cellular response to heat stress R-HSA-3371556 3.454731e-07 6.462 0 0
Cellular Senescence R-HSA-2559583 4.855357e-07 6.314 1 0
Chromatin organization R-HSA-4839726 7.746525e-07 6.111 0 0
HSF1-dependent transactivation R-HSA-3371571 1.329036e-06 5.876 0 0
M Phase R-HSA-68886 1.500781e-06 5.824 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 9.245408e-06 5.034 0 0
Attenuation phase R-HSA-3371568 1.063357e-05 4.973 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.336505e-05 4.874 0 0
Chromatin modifying enzymes R-HSA-3247509 1.281944e-05 4.892 0 0
Apoptosis R-HSA-109581 1.471776e-05 4.832 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 3.392268e-05 4.470 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 3.402467e-05 4.468 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 3.949360e-05 4.403 0 0
HSF1 activation R-HSA-3371511 5.123466e-05 4.290 0 0
Diseases of mitotic cell cycle R-HSA-9675126 5.091893e-05 4.293 0 0
Programmed Cell Death R-HSA-5357801 4.780000e-05 4.321 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 5.796906e-05 4.237 0 0
Signaling by ALK in cancer R-HSA-9700206 5.796906e-05 4.237 0 0
Mitotic Anaphase R-HSA-68882 6.988736e-05 4.156 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 7.679617e-05 4.115 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.120252e-04 3.951 0 0
NRAGE signals death through JNK R-HSA-193648 1.450461e-04 3.838 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.906616e-04 3.720 0 0
Mitotic Prometaphase R-HSA-68877 2.110484e-04 3.676 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.848399e-04 3.545 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 3.073806e-04 3.512 0 0
Cellular responses to stress R-HSA-2262752 3.652193e-04 3.437 1 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 4.376485e-04 3.359 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 4.270111e-04 3.370 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 4.270111e-04 3.370 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 4.147580e-04 3.382 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 5.100963e-04 3.292 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 6.129568e-04 3.213 0 0
G alpha (12/13) signalling events R-HSA-416482 7.117171e-04 3.148 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 8.253684e-04 3.083 0 0
Cell-extracellular matrix interactions R-HSA-446353 8.652967e-04 3.063 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 8.638728e-04 3.064 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.039243e-03 2.983 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.131262e-03 2.946 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.097714e-03 2.960 0 0
Cellular responses to stimuli R-HSA-8953897 1.140724e-03 2.943 1 0
Signal Transduction R-HSA-162582 1.196877e-03 2.922 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.316596e-03 2.881 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.325502e-03 2.878 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.609266e-03 2.793 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 1.609266e-03 2.793 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.591279e-03 2.798 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.435087e-03 2.843 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.690717e-03 2.772 0 0
Nuclear Receptor transcription pathway R-HSA-383280 1.693901e-03 2.771 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.000914e-03 2.699 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.000914e-03 2.699 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 2.094235e-03 2.679 0 0
S Phase R-HSA-69242 2.289882e-03 2.640 0 0
Gene expression (Transcription) R-HSA-74160 2.360037e-03 2.627 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 2.390345e-03 2.622 0 0
Axon guidance R-HSA-422475 2.397387e-03 2.620 0 0
Separation of Sister Chromatids R-HSA-2467813 2.530800e-03 2.597 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 2.772707e-03 2.557 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.702298e-03 2.568 0 0
Mitotic Prophase R-HSA-68875 3.405633e-03 2.468 0 0
Epigenetic regulation of gene expression R-HSA-212165 3.528686e-03 2.452 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 3.885561e-03 2.411 0 0
Oncogenic MAPK signaling R-HSA-6802957 3.916500e-03 2.407 0 0
Nervous system development R-HSA-9675108 3.964157e-03 2.402 0 0
mRNA 3'-end processing R-HSA-72187 4.059254e-03 2.392 0 0
Formation of definitive endoderm R-HSA-9823730 4.604438e-03 2.337 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 4.740779e-03 2.324 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 4.765574e-03 2.322 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 4.882844e-03 2.311 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 5.652207e-03 2.248 0 0
HATs acetylate histones R-HSA-3214847 5.347422e-03 2.272 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 5.347422e-03 2.272 0 0
Cell Cycle Checkpoints R-HSA-69620 5.363135e-03 2.271 0 0
mRNA Splicing R-HSA-72172 5.837209e-03 2.234 0 0
Cell-Cell communication R-HSA-1500931 5.839125e-03 2.234 0 0
MTOR signalling R-HSA-165159 6.032144e-03 2.220 0 0
Membrane Trafficking R-HSA-199991 6.981331e-03 2.156 0 0
Death Receptor Signaling R-HSA-73887 6.771581e-03 2.169 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 7.165057e-03 2.145 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 7.537196e-03 2.123 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 7.537196e-03 2.123 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 7.124294e-03 2.147 1 1
Resolution of Sister Chromatid Cohesion R-HSA-2500257 7.123489e-03 2.147 0 0
Semaphorin interactions R-HSA-373755 7.232166e-03 2.141 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 7.165057e-03 2.145 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 7.601693e-03 2.119 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 8.248520e-03 2.084 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 8.248520e-03 2.084 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 8.248520e-03 2.084 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 8.248520e-03 2.084 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 8.248520e-03 2.084 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 8.248520e-03 2.084 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 8.248520e-03 2.084 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 8.248520e-03 2.084 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 8.248520e-03 2.084 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 8.248520e-03 2.084 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 8.248520e-03 2.084 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 8.019987e-03 2.096 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 8.538217e-03 2.069 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 9.015204e-03 2.045 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 8.888274e-03 2.051 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 8.888274e-03 2.051 0 0
Clathrin-mediated endocytosis R-HSA-8856828 9.311897e-03 2.031 0 0
L1CAM interactions R-HSA-373760 8.740905e-03 2.058 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.061585e-02 1.974 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.061585e-02 1.974 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.061585e-02 1.974 0 0
Nuclear import of Rev protein R-HSA-180746 1.041741e-02 1.982 0 0
Signaling by RAS mutants R-HSA-6802949 1.061585e-02 1.974 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 1.072361e-02 1.970 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.005300e-02 1.998 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.067576e-02 1.972 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.142335e-02 1.942 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.266403e-02 1.897 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.311536e-02 1.882 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.373825e-02 1.862 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.495786e-02 1.825 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.561908e-02 1.806 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.561908e-02 1.806 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.485400e-02 1.828 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.570339e-02 1.804 0 0
Signaling by EGFR R-HSA-177929 1.579930e-02 1.801 0 0
Cell junction organization R-HSA-446728 1.592116e-02 1.798 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.642555e-02 1.784 0 0
Phosphorylation of the APC/C R-HSA-176412 1.762675e-02 1.754 0 0
Metabolism of RNA R-HSA-8953854 1.764883e-02 1.753 0 0
Regulation of CDH1 Function R-HSA-9764561 1.767175e-02 1.753 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.802030e-02 1.744 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.802030e-02 1.744 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.802030e-02 1.744 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.802030e-02 1.744 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.802030e-02 1.744 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.802030e-02 1.744 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 1.802030e-02 1.744 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 1.812433e-02 1.742 0 0
Switching of origins to a post-replicative state R-HSA-69052 2.109299e-02 1.676 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.987077e-02 1.702 0 0
Interaction between L1 and Ankyrins R-HSA-445095 2.127768e-02 1.672 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 2.134026e-02 1.671 0 0
Disorders of Developmental Biology R-HSA-9675151 2.174016e-02 1.663 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.174016e-02 1.663 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 2.174016e-02 1.663 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 2.174016e-02 1.663 0 0
Synthesis of DNA R-HSA-69239 2.221183e-02 1.653 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 2.400805e-02 1.620 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 2.400805e-02 1.620 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 2.400805e-02 1.620 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.499282e-02 1.602 0 0
Pervasive developmental disorders R-HSA-9005895 2.499282e-02 1.602 0 0
Disorders of Nervous System Development R-HSA-9697154 2.499282e-02 1.602 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.499282e-02 1.602 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.395808e-02 1.621 0 0
RNA Polymerase II Transcription R-HSA-73857 2.258081e-02 1.646 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 2.411083e-02 1.618 0 0
mTORC1-mediated signalling R-HSA-166208 2.608453e-02 1.584 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.627196e-02 1.581 0 0
RAF activation R-HSA-5673000 2.644804e-02 1.578 0 0
Signaling by Hippo R-HSA-2028269 2.645640e-02 1.577 0 0
Formation of annular gap junctions R-HSA-196025 2.695702e-02 1.569 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 2.695702e-02 1.569 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 2.963676e-02 1.528 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 3.013449e-02 1.521 0 0
Formation of axial mesoderm R-HSA-9796292 3.122286e-02 1.506 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 3.122286e-02 1.506 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 3.122286e-02 1.506 0 0
IRS activation R-HSA-74713 3.542613e-02 1.451 0 0
G2 Phase R-HSA-68911 3.542613e-02 1.451 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 3.542613e-02 1.451 0 0
GP1b-IX-V activation signalling R-HSA-430116 3.532848e-02 1.452 0 0
Gap junction degradation R-HSA-190873 3.532848e-02 1.452 0 0
ALK mutants bind TKIs R-HSA-9700645 3.532848e-02 1.452 0 0
Activation of the pre-replicative complex R-HSA-68962 3.302955e-02 1.481 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 3.302955e-02 1.481 0 0
RUNX2 regulates bone development R-HSA-8941326 3.416496e-02 1.466 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 3.257566e-02 1.487 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 3.625295e-02 1.441 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 3.180565e-02 1.497 0 0
XBP1(S) activates chaperone genes R-HSA-381038 3.704741e-02 1.431 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 3.756893e-02 1.425 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 3.776847e-02 1.423 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 3.776847e-02 1.423 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 3.781321e-02 1.422 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.794992e-02 1.421 0 0
HIV Life Cycle R-HSA-162587 3.852582e-02 1.414 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 3.855208e-02 1.414 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.855208e-02 1.414 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 4.065137e-02 1.391 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 4.089004e-02 1.388 0 0
Sema4D in semaphorin signaling R-HSA-400685 4.134424e-02 1.384 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 4.504181e-02 1.346 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 4.504181e-02 1.346 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 4.449925e-02 1.352 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.749371e-02 1.323 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 4.856453e-02 1.314 0 0
G0 and Early G1 R-HSA-1538133 4.294282e-02 1.367 0 0
Signal attenuation R-HSA-74749 4.504181e-02 1.346 0 0
Myogenesis R-HSA-525793 4.749371e-02 1.323 0 0
DCC mediated attractive signaling R-HSA-418885 4.638402e-02 1.334 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 4.449925e-02 1.352 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 4.504181e-02 1.346 0 0
Regulation of beta-cell development R-HSA-186712 4.458514e-02 1.351 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 4.844045e-02 1.315 0 0
p38MAPK events R-HSA-171007 4.638402e-02 1.334 0 0
ISG15 antiviral mechanism R-HSA-1169408 4.814619e-02 1.317 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 4.756561e-02 1.323 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 4.330722e-02 1.363 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 4.915997e-02 1.308 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 4.915997e-02 1.308 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 4.915997e-02 1.308 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 5.075374e-02 1.295 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 5.187864e-02 1.285 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 5.187864e-02 1.285 0 0
Signalling to RAS R-HSA-167044 5.187864e-02 1.285 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 5.307091e-02 1.275 0 0
MAP kinase activation R-HSA-450294 5.322542e-02 1.274 1 0
Signaling by VEGF R-HSA-194138 5.354738e-02 1.271 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 5.370792e-02 1.270 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 5.396043e-02 1.268 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 6.318460e-02 1.199 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 6.509832e-02 1.186 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 5.609740e-02 1.251 0 0
Signaling by APC mutants R-HSA-4839744 5.609740e-02 1.251 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 5.609740e-02 1.251 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 5.609740e-02 1.251 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 5.609740e-02 1.251 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 5.534951e-02 1.257 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 6.524455e-02 1.185 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 5.996084e-02 1.222 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 5.996084e-02 1.222 0 0
Striated Muscle Contraction R-HSA-390522 5.464347e-02 1.262 0 0
Recycling pathway of L1 R-HSA-437239 5.795175e-02 1.237 0 0
Translation initiation complex formation R-HSA-72649 5.568075e-02 1.254 0 0
Nucleotide Excision Repair R-HSA-5696398 5.778334e-02 1.238 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 5.996084e-02 1.222 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 5.987435e-02 1.223 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 6.318460e-02 1.199 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 5.609740e-02 1.251 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 5.464347e-02 1.262 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 5.534951e-02 1.257 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 6.524455e-02 1.185 0 0
IRE1alpha activates chaperones R-HSA-381070 5.757884e-02 1.240 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 6.572902e-02 1.182 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 6.634829e-02 1.178 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 6.679037e-02 1.175 0 0
Signalling to ERKs R-HSA-187687 6.820175e-02 1.166 0 0
Activation of RAC1 R-HSA-428540 6.847498e-02 1.164 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 6.847498e-02 1.164 0 0
Signaling by GSK3beta mutants R-HSA-5339716 6.847498e-02 1.164 0 0
Signaling by AXIN mutants R-HSA-4839735 6.847498e-02 1.164 0 0
Signaling by AMER1 mutants R-HSA-4839748 6.847498e-02 1.164 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 6.955014e-02 1.158 0 0
Regulation of TP53 Activity R-HSA-5633007 6.958212e-02 1.158 0 0
Estrogen-dependent gene expression R-HSA-9018519 6.987798e-02 1.156 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 7.007806e-02 1.154 0 0
Signaling by MET R-HSA-6806834 7.007806e-02 1.154 0 0
Adherens junctions interactions R-HSA-418990 7.101778e-02 1.149 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 7.214549e-02 1.142 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 7.373823e-02 1.132 0 0
DNA Replication Pre-Initiation R-HSA-69002 7.380756e-02 1.132 0 0
Signaling by ROBO receptors R-HSA-376176 7.460102e-02 1.127 0 0
Selective autophagy R-HSA-9663891 7.520775e-02 1.124 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 7.606198e-02 1.119 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 7.606198e-02 1.119 0 0
Cap-dependent Translation Initiation R-HSA-72737 7.722394e-02 1.112 0 0
Eukaryotic Translation Initiation R-HSA-72613 7.722394e-02 1.112 0 0
Defective Base Excision Repair Associated with NEIL1 R-HSA-9616334 9.655227e-02 1.015 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 9.655227e-02 1.015 0 0
MET interacts with TNS proteins R-HSA-8875513 9.251535e-02 1.034 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 9.251535e-02 1.034 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 8.308720e-02 1.080 0 0
SOS-mediated signalling R-HSA-112412 8.308720e-02 1.080 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 8.308720e-02 1.080 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 8.213598e-02 1.085 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 8.213598e-02 1.085 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 8.213598e-02 1.085 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 8.213598e-02 1.085 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 8.213598e-02 1.085 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 8.778579e-02 1.057 0 0
EGFR downregulation R-HSA-182971 8.666200e-02 1.062 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 8.365286e-02 1.078 0 0
snRNP Assembly R-HSA-191859 8.468072e-02 1.072 0 0
Metabolism of non-coding RNA R-HSA-194441 8.468072e-02 1.072 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 9.142155e-02 1.039 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 8.843889e-02 1.053 0 0
EPHB-mediated forward signaling R-HSA-3928662 8.755867e-02 1.058 0 0
DNA strand elongation R-HSA-69190 9.619228e-02 1.017 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 8.843889e-02 1.053 0 0
Chaperone Mediated Autophagy R-HSA-9613829 8.778579e-02 1.057 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 8.213598e-02 1.085 0 0
Activation of BH3-only proteins R-HSA-114452 7.769415e-02 1.110 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 8.213598e-02 1.085 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 8.213598e-02 1.085 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 9.006815e-02 1.045 0 0
Mitotic G2-G2/M phases R-HSA-453274 8.179817e-02 1.087 0 0
Macroautophagy R-HSA-1632852 8.998853e-02 1.046 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 9.251535e-02 1.034 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 7.824475e-02 1.107 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 9.409532e-02 1.026 1 0
Uptake and function of diphtheria toxin R-HSA-5336415 8.308720e-02 1.080 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 9.749087e-02 1.011 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 9.873017e-02 1.006 0 0
Late Phase of HIV Life Cycle R-HSA-162599 9.899616e-02 1.004 0 0
Long-term potentiation R-HSA-9620244 9.932110e-02 1.003 0 0
HDMs demethylate histones R-HSA-3214842 9.932110e-02 1.003 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 1.003918e-01 0.998 0 0
Chromosome Maintenance R-HSA-73886 1.008802e-01 0.996 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.009961e-01 0.996 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 1.029433e-01 0.987 0 0
Type I hemidesmosome assembly R-HSA-446107 1.029433e-01 0.987 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.029433e-01 0.987 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.029433e-01 0.987 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.029433e-01 0.987 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 1.038356e-01 0.984 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 1.038356e-01 0.984 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.038356e-01 0.984 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 1.053213e-01 0.977 0 0
Interleukin-17 signaling R-HSA-448424 1.056868e-01 0.976 1 0
ESR-mediated signaling R-HSA-8939211 1.059067e-01 0.975 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.062771e-01 0.974 0 0
Deubiquitination R-HSA-5688426 1.072765e-01 0.969 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.088023e-01 0.963 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.104514e-01 0.957 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.107684e-01 0.956 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.129256e-01 0.947 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.138486e-01 0.944 0 0
Negative regulation of MET activity R-HSA-6807004 1.138486e-01 0.944 0 0
Nephrin family interactions R-HSA-373753 1.138486e-01 0.944 0 0
Regulation of gap junction activity R-HSA-191650 1.249170e-01 0.903 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.249170e-01 0.903 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.249170e-01 0.903 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.244648e-01 0.905 0 0
WNT mediated activation of DVL R-HSA-201688 1.244648e-01 0.905 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 1.474400e-01 0.831 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.302126e-01 0.885 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.302126e-01 0.885 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.483438e-01 0.829 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.281178e-01 0.892 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.281178e-01 0.892 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 1.281178e-01 0.892 1 1
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 1.431558e-01 0.844 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.230818e-01 0.910 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.401080e-01 0.854 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.384298e-01 0.859 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.282403e-01 0.892 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.594966e-01 0.797 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.565145e-01 0.805 0 0
Centrosome maturation R-HSA-380287 1.446490e-01 0.840 0 0
Regulation of gene expression in beta cells R-HSA-210745 1.493500e-01 0.826 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.498217e-01 0.824 0 0
Signaling by ERBB2 R-HSA-1227986 1.594966e-01 0.797 0 0
MAP2K and MAPK activation R-HSA-5674135 1.304709e-01 0.884 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.519016e-01 0.818 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.431558e-01 0.844 0 0
Cell-cell junction organization R-HSA-421270 1.265378e-01 0.898 0 0
DNA Replication R-HSA-69306 1.584926e-01 0.800 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.338909e-01 0.873 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.363099e-01 0.865 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.474400e-01 0.831 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.304709e-01 0.884 0 0
Kinesins R-HSA-983189 1.594966e-01 0.797 0 0
Autophagy R-HSA-9612973 1.257434e-01 0.901 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 1.201956e-01 0.920 0 0
HIV Infection R-HSA-162906 1.385447e-01 0.858 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.230818e-01 0.910 0 0
G2/M Transition R-HSA-69275 1.507373e-01 0.822 0 0
Rab regulation of trafficking R-HSA-9007101 1.259341e-01 0.900 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.249170e-01 0.903 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 1.249170e-01 0.903 0 0
Unwinding of DNA R-HSA-176974 1.244648e-01 0.905 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.244648e-01 0.905 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 1.483438e-01 0.829 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 1.446490e-01 0.840 0 0
MyD88-independent TLR4 cascade R-HSA-166166 1.228209e-01 0.911 1 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 1.228209e-01 0.911 1 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.244648e-01 0.905 0 0
MAPK family signaling cascades R-HSA-5683057 1.508141e-01 0.822 0 0
FLT3 Signaling R-HSA-9607240 1.201956e-01 0.920 0 0
Josephin domain DUBs R-HSA-5689877 1.474400e-01 0.831 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.589138e-01 0.799 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.201956e-01 0.920 0 0
Interleukin-12 signaling R-HSA-9020591 1.532525e-01 0.815 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 1.595238e-01 0.797 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.595238e-01 0.797 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 1.595238e-01 0.797 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 1.595238e-01 0.797 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 1.595238e-01 0.797 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 1.595238e-01 0.797 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 1.595238e-01 0.797 0 0
NrCAM interactions R-HSA-447038 1.595238e-01 0.797 0 0
EPH-Ephrin signaling R-HSA-2682334 1.622117e-01 0.790 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.633531e-01 0.787 0 0
Interleukin-37 signaling R-HSA-9008059 1.633531e-01 0.787 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.638546e-01 0.786 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 1.667081e-01 0.778 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 1.673784e-01 0.776 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.696612e-01 0.770 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.716540e-01 0.765 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 1.730036e-01 0.762 0 0
Smooth Muscle Contraction R-HSA-445355 1.730036e-01 0.762 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 2.626038e-01 0.581 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.626038e-01 0.581 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 2.626038e-01 0.581 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 2.626038e-01 0.581 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 2.626038e-01 0.581 0 0
Defective VWF binding to collagen type I R-HSA-9845622 2.626038e-01 0.581 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 2.626038e-01 0.581 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.626038e-01 0.581 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 2.626038e-01 0.581 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 1.956086e-01 0.709 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 1.956086e-01 0.709 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.956086e-01 0.709 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.338137e-01 0.476 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.338137e-01 0.476 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 3.338137e-01 0.476 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 3.338137e-01 0.476 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 3.338137e-01 0.476 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 3.338137e-01 0.476 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.338137e-01 0.476 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 1.968942e-01 0.706 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.698855e-01 0.569 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.698855e-01 0.569 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 2.698855e-01 0.569 0 0
IFNG signaling activates MAPKs R-HSA-9732724 2.698855e-01 0.569 0 0
Recycling of eIF2:GDP R-HSA-72731 2.698855e-01 0.569 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 3.981507e-01 0.400 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 3.981507e-01 0.400 0 0
Invadopodia formation R-HSA-8941237 3.981507e-01 0.400 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 3.981507e-01 0.400 0 0
Defective DPM2 causes DPM2-CDG R-HSA-4719377 3.981507e-01 0.400 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 3.981507e-01 0.400 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 3.981507e-01 0.400 0 0
Defective DPM3 causes DPM3-CDG R-HSA-4719360 3.981507e-01 0.400 0 0
Defective DPM1 causes DPM1-CDG R-HSA-4717374 3.981507e-01 0.400 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 2.229543e-01 0.652 0 0
Repression of WNT target genes R-HSA-4641265 2.229543e-01 0.652 0 0
Polymerase switching R-HSA-69091 2.229543e-01 0.652 0 0
Leading Strand Synthesis R-HSA-69109 2.229543e-01 0.652 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.229543e-01 0.652 0 0
Regulation by c-FLIP R-HSA-3371378 3.071584e-01 0.513 0 0
Dimerization of procaspase-8 R-HSA-69416 3.071584e-01 0.513 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 3.071584e-01 0.513 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 3.071584e-01 0.513 0 0
Ephrin signaling R-HSA-3928664 2.077656e-01 0.682 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 2.077656e-01 0.682 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 1.923755e-01 0.716 0 0
Deadenylation of mRNA R-HSA-429947 1.923755e-01 0.716 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 2.767572e-01 0.558 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 3.440443e-01 0.463 0 0
Lipophagy R-HSA-9613354 3.440443e-01 0.463 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 3.440443e-01 0.463 0 0
CASP8 activity is inhibited R-HSA-5218900 3.440443e-01 0.463 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 4.562778e-01 0.341 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 4.562778e-01 0.341 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 4.562778e-01 0.341 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 4.562778e-01 0.341 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 4.562778e-01 0.341 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.562778e-01 0.341 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 4.562778e-01 0.341 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 4.562778e-01 0.341 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.562778e-01 0.341 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 2.099648e-01 0.678 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 1.929286e-01 0.715 0 0
Erythropoietin activates RAS R-HSA-9027284 3.041417e-01 0.517 0 0
Processive synthesis on the lagging strand R-HSA-69183 3.041417e-01 0.517 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 3.041417e-01 0.517 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 3.041417e-01 0.517 0 0
Signaling by EGFR in Cancer R-HSA-1643713 2.280468e-01 0.642 0 0
Lagging Strand Synthesis R-HSA-69186 2.726372e-01 0.564 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 2.726372e-01 0.564 0 0
2-LTR circle formation R-HSA-164843 3.802706e-01 0.420 0 0
Folding of actin by CCT/TriC R-HSA-390450 3.802706e-01 0.420 0 0
DNA replication initiation R-HSA-68952 3.802706e-01 0.420 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 3.802706e-01 0.420 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.465603e-01 0.608 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.465603e-01 0.608 0 0
Nucleosome assembly R-HSA-774815 1.757846e-01 0.755 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 1.757846e-01 0.755 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 2.243457e-01 0.649 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.880866e-01 0.726 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 2.950103e-01 0.530 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 2.654440e-01 0.576 0 0
Formation of the Early Elongation Complex R-HSA-113418 2.654440e-01 0.576 0 0
HIV elongation arrest and recovery R-HSA-167287 2.654440e-01 0.576 0 0
Pausing and recovery of HIV elongation R-HSA-167290 2.654440e-01 0.576 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 2.007411e-01 0.697 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 2.846365e-01 0.546 0 0
Late endosomal microautophagy R-HSA-9615710 2.846365e-01 0.546 0 0
Notch-HLH transcription pathway R-HSA-350054 3.176009e-01 0.498 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.176009e-01 0.498 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 3.590821e-01 0.445 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 4.156209e-01 0.381 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 4.156209e-01 0.381 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 5.087940e-01 0.293 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 5.087940e-01 0.293 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 5.087940e-01 0.293 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 5.087940e-01 0.293 0 0
Defective F9 activation R-HSA-9673221 5.087940e-01 0.293 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.087940e-01 0.293 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.908791e-01 0.719 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.908791e-01 0.719 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 2.078537e-01 0.682 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 2.489014e-01 0.604 0 0
G1/S-Specific Transcription R-HSA-69205 2.742155e-01 0.562 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 3.863629e-01 0.413 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.247468e-01 0.648 0 0
Orc1 removal from chromatin R-HSA-68949 2.685481e-01 0.571 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 2.685481e-01 0.571 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 2.685481e-01 0.571 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 4.499265e-01 0.347 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 4.499265e-01 0.347 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.828546e-01 0.548 0 0
Meiotic synapsis R-HSA-1221632 2.828546e-01 0.548 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 2.828546e-01 0.548 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 4.133577e-01 0.384 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 2.019464e-01 0.695 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 3.440614e-01 0.463 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 3.120192e-01 0.506 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 3.268279e-01 0.486 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 4.084441e-01 0.389 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 4.830596e-01 0.316 0 0
GRB2 events in EGFR signaling R-HSA-179812 4.830596e-01 0.316 0 0
Scavenging by Class F Receptors R-HSA-3000484 4.830596e-01 0.316 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.857718e-01 0.544 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 3.796740e-01 0.421 0 0
HIV Transcription Initiation R-HSA-167161 3.796740e-01 0.421 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 3.796740e-01 0.421 0 0
Dual Incision in GG-NER R-HSA-5696400 4.029921e-01 0.395 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 4.308959e-01 0.366 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 3.374158e-01 0.472 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 3.678641e-01 0.434 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 4.153293e-01 0.382 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 5.149268e-01 0.288 0 0
Termination of translesion DNA synthesis R-HSA-5656169 4.750352e-01 0.323 0 0
Formation of a pool of free 40S subunits R-HSA-72689 3.923223e-01 0.406 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 4.507418e-01 0.346 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 3.818266e-01 0.418 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 3.818266e-01 0.418 0 0
HDACs deacetylate histones R-HSA-3214815 4.572605e-01 0.340 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 4.489192e-01 0.348 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 5.188559e-01 0.285 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 5.188559e-01 0.285 0 0
Dual incision in TC-NER R-HSA-6782135 5.051167e-01 0.297 0 0
Degradation of CDH1 R-HSA-9766229 5.198337e-01 0.284 0 0
Chaperonin-mediated protein folding R-HSA-390466 5.103631e-01 0.292 0 0
Peptide chain elongation R-HSA-156902 5.233402e-01 0.281 0 0
Transcription of the HIV genome R-HSA-167172 2.485283e-01 0.605 0 0
Signaling by NOTCH1 R-HSA-1980143 3.506148e-01 0.455 0 0
Developmental Cell Lineages R-HSA-9734767 2.345040e-01 0.630 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 4.084441e-01 0.389 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 3.595368e-01 0.444 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 3.796740e-01 0.421 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.818253e-01 0.740 0 0
Telomere Maintenance R-HSA-157579 4.166194e-01 0.380 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 3.349085e-01 0.475 0 0
HIV Transcription Elongation R-HSA-167169 5.188559e-01 0.285 0 0
Extension of Telomeres R-HSA-180786 3.718645e-01 0.430 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.268459e-01 0.644 0 0
Regulation of mitotic cell cycle R-HSA-453276 2.857066e-01 0.544 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 2.857066e-01 0.544 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 3.040772e-01 0.517 0 0
G1/S Transition R-HSA-69206 3.516891e-01 0.454 0 0
MET promotes cell motility R-HSA-8875878 3.087999e-01 0.510 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 3.962098e-01 0.402 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 4.966155e-01 0.304 0 0
Killing mechanisms R-HSA-9664420 3.316316e-01 0.479 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 3.316316e-01 0.479 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 4.234670e-01 0.373 0 0
DNA Damage Bypass R-HSA-73893 2.270244e-01 0.644 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 4.029921e-01 0.395 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 2.843249e-01 0.546 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 5.188559e-01 0.285 0 0
Aggrephagy R-HSA-9646399 2.050583e-01 0.688 0 0
G-protein beta:gamma signalling R-HSA-397795 3.633044e-01 0.440 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 3.618436e-01 0.441 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 2.505743e-01 0.601 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 3.040772e-01 0.517 0 0
Integration of provirus R-HSA-162592 4.499265e-01 0.347 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.452644e-01 0.610 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 4.246184e-01 0.372 0 0
DARPP-32 events R-HSA-180024 4.750352e-01 0.323 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 4.966155e-01 0.304 0 0
COPI-mediated anterograde transport R-HSA-6807878 5.241424e-01 0.281 0 0
Cyclin D associated events in G1 R-HSA-69231 2.795818e-01 0.553 0 0
G1 Phase R-HSA-69236 2.795818e-01 0.553 0 0
GAB1 signalosome R-HSA-180292 4.133577e-01 0.384 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 4.044627e-01 0.393 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 2.952639e-01 0.530 0 0
Co-inhibition by CTLA4 R-HSA-389513 2.505743e-01 0.601 0 0
Regulation of CDH11 function R-HSA-9762292 3.802706e-01 0.420 0 0
PI3K/AKT activation R-HSA-198203 3.802706e-01 0.420 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 3.802706e-01 0.420 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 3.590821e-01 0.445 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 4.499265e-01 0.347 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 5.001130e-01 0.301 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 5.188559e-01 0.285 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 1.801257e-01 0.744 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 3.591580e-01 0.445 0 0
Eukaryotic Translation Elongation R-HSA-156842 4.616044e-01 0.336 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 2.742155e-01 0.562 0 0
RNA Polymerase III Transcription R-HSA-74158 2.742155e-01 0.562 0 0
CREB phosphorylation R-HSA-199920 2.325639e-01 0.633 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 2.742155e-01 0.562 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 3.403207e-01 0.468 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.901878e-01 0.721 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 3.263667e-01 0.486 0 0
E2F mediated regulation of DNA replication R-HSA-113510 4.399637e-01 0.357 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 4.830596e-01 0.316 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 5.149268e-01 0.288 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 4.085037e-01 0.389 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 2.280468e-01 0.642 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 4.499265e-01 0.347 0 0
UCH proteinases R-HSA-5689603 2.394027e-01 0.621 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 2.526577e-01 0.597 0 0
Protein ubiquitination R-HSA-8852135 2.282229e-01 0.642 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 2.325639e-01 0.633 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.857356e-01 0.731 0 0
MET activates RAS signaling R-HSA-8851805 2.229543e-01 0.652 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 1.753390e-01 0.756 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 2.452644e-01 0.610 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 3.263667e-01 0.486 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 4.084441e-01 0.389 0 0
Signaling by WNT in cancer R-HSA-4791275 1.929286e-01 0.715 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 2.465603e-01 0.608 0 0
DNA Double Strand Break Response R-HSA-5693606 3.537624e-01 0.451 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.911453e-01 0.719 0 0
Homology Directed Repair R-HSA-5693538 4.712935e-01 0.327 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.956086e-01 0.709 0 0
Adrenoceptors R-HSA-390696 3.071584e-01 0.513 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 2.767572e-01 0.558 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.562778e-01 0.341 0 0
Nuclear RNA decay R-HSA-9930044 2.084266e-01 0.681 0 0
Formation of the posterior neural plate R-HSA-9832991 4.156209e-01 0.381 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.087940e-01 0.293 0 0
Activation of AKT2 R-HSA-165158 5.087940e-01 0.293 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 4.499265e-01 0.347 0 0
DNA Double-Strand Break Repair R-HSA-5693532 3.779787e-01 0.423 0 0
Signaling by Nuclear Receptors R-HSA-9006931 5.147976e-01 0.288 0 0
TCF dependent signaling in response to WNT R-HSA-201681 3.187645e-01 0.497 0 0
Neurexins and neuroligins R-HSA-6794361 4.085037e-01 0.389 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 3.041417e-01 0.517 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 5.149268e-01 0.288 0 0
Frs2-mediated activation R-HSA-170968 5.149268e-01 0.288 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 4.084441e-01 0.389 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.880866e-01 0.726 0 0
Generic Transcription Pathway R-HSA-212436 1.838351e-01 0.736 0 0
FasL/ CD95L signaling R-HSA-75157 3.981507e-01 0.400 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 5.087940e-01 0.293 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 3.863629e-01 0.413 0 0
DNA Repair R-HSA-73894 3.685849e-01 0.433 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 4.651798e-01 0.332 0 0
TNF signaling R-HSA-75893 3.268279e-01 0.486 0 0
Signaling by NODAL R-HSA-1181150 4.660915e-01 0.332 0 0
Rap1 signalling R-HSA-392517 4.399637e-01 0.357 0 0
Vesicle-mediated transport R-HSA-5653656 2.044578e-01 0.689 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 4.227440e-01 0.374 0 0
Circadian clock R-HSA-9909396 2.526577e-01 0.597 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.908791e-01 0.719 0 0
Signaling by PTK6 R-HSA-8848021 1.908791e-01 0.719 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 3.041417e-01 0.517 0 0
Signal transduction by L1 R-HSA-445144 4.660915e-01 0.332 0 0
Platelet degranulation R-HSA-114608 4.739508e-01 0.324 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 3.432993e-01 0.464 0 0
Calmodulin induced events R-HSA-111933 2.742155e-01 0.562 0 0
Mitophagy R-HSA-5205647 4.029921e-01 0.395 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 2.847534e-01 0.546 0 0
Protein-protein interactions at synapses R-HSA-6794362 3.474005e-01 0.459 0 0
Post NMDA receptor activation events R-HSA-438064 2.744561e-01 0.562 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 3.638264e-01 0.439 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 1.837874e-01 0.736 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.626038e-01 0.581 0 0
mRNA Editing: A to I Conversion R-HSA-75064 3.338137e-01 0.476 0 0
C6 deamination of adenosine R-HSA-75102 3.338137e-01 0.476 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.338137e-01 0.476 0 0
Activation of BMF and translocation to mitochondria R-HSA-139910 3.981507e-01 0.400 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 3.981507e-01 0.400 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 3.071584e-01 0.513 0 0
Synaptic adhesion-like molecules R-HSA-8849932 2.077656e-01 0.682 0 0
Neurodegenerative Diseases R-HSA-8863678 1.923755e-01 0.716 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.923755e-01 0.716 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 3.041417e-01 0.517 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 3.802706e-01 0.420 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.757846e-01 0.755 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 2.654440e-01 0.576 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.846365e-01 0.546 0 0
Ionotropic activity of kainate receptors R-HSA-451306 4.156209e-01 0.381 0 0
Reelin signalling pathway R-HSA-8866376 5.087940e-01 0.293 0 0
CaM pathway R-HSA-111997 2.742155e-01 0.562 0 0
Ovarian tumor domain proteases R-HSA-5689896 2.914021e-01 0.536 0 0
Presynaptic function of Kainate receptors R-HSA-500657 4.133577e-01 0.384 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 2.344871e-01 0.630 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 4.531118e-01 0.344 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.764022e-01 0.753 0 0
Early Phase of HIV Life Cycle R-HSA-162594 2.726372e-01 0.564 0 0
Base Excision Repair R-HSA-73884 4.234670e-01 0.373 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 4.029921e-01 0.395 0 0
Oncogene Induced Senescence R-HSA-2559585 4.227440e-01 0.374 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 3.769325e-01 0.424 1 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 3.313441e-01 0.480 1 0
Regulation of PTEN gene transcription R-HSA-8943724 2.582216e-01 0.588 0 0
Pexophagy R-HSA-9664873 3.802706e-01 0.420 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 3.769325e-01 0.424 1 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 4.091999e-01 0.388 1 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 2.465603e-01 0.608 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 3.633044e-01 0.440 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 2.122893e-01 0.673 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 4.091999e-01 0.388 1 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 3.863629e-01 0.413 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 3.268279e-01 0.486 0 0
Ca-dependent events R-HSA-111996 3.975148e-01 0.401 0 0
Developmental Biology R-HSA-1266738 4.757084e-01 0.323 0 0
ERK/MAPK targets R-HSA-198753 2.726372e-01 0.564 0 0
Receptor Mediated Mitophagy R-HSA-8934903 3.802706e-01 0.420 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 5.087940e-01 0.293 0 0
TBC/RABGAPs R-HSA-8854214 2.641171e-01 0.578 0 0
DAG and IP3 signaling R-HSA-1489509 4.507418e-01 0.346 0 0
Gastrulation R-HSA-9758941 3.405644e-01 0.468 0 0
Negative regulation of FLT3 R-HSA-9706369 3.316316e-01 0.479 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.623476e-01 0.581 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 3.071584e-01 0.513 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.087940e-01 0.293 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 3.863629e-01 0.413 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 2.984376e-01 0.525 0 0
Signaling by LTK R-HSA-9842663 4.830596e-01 0.316 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 4.857341e-01 0.314 0 0
Diseases of programmed cell death R-HSA-9645723 3.979916e-01 0.400 0 0
TGFBR3 expression R-HSA-9839394 2.099648e-01 0.678 0 0
Netrin-1 signaling R-HSA-373752 2.795818e-01 0.553 0 0
Mismatch Repair R-HSA-5358508 4.133577e-01 0.384 0 0
Generation of second messenger molecules R-HSA-202433 5.188559e-01 0.285 0 0
Inhibition of membrane repair R-HSA-9635644 2.626038e-01 0.581 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.626038e-01 0.581 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 2.496372e-01 0.603 0 0
Protein methylation R-HSA-8876725 3.041417e-01 0.517 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 3.041417e-01 0.517 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 4.156209e-01 0.381 0 0
Platelet sensitization by LDL R-HSA-432142 4.133577e-01 0.384 0 0
Regulation of necroptotic cell death R-HSA-5675482 3.633044e-01 0.440 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 4.830596e-01 0.316 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 5.149268e-01 0.288 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 3.377083e-01 0.471 1 0
Signaling by PDGFR in disease R-HSA-9671555 5.166163e-01 0.287 0 0
Host Interactions of HIV factors R-HSA-162909 4.308054e-01 0.366 0 0
Interferon Signaling R-HSA-913531 4.598293e-01 0.337 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.959999e-01 0.708 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 3.796740e-01 0.421 0 0
Muscle contraction R-HSA-397014 4.911523e-01 0.309 0 0
Signal regulatory protein family interactions R-HSA-391160 2.767572e-01 0.558 0 0
PKR-mediated signaling R-HSA-9833482 1.901878e-01 0.721 0 0
Protein hydroxylation R-HSA-9629569 4.660915e-01 0.332 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.854378e-01 0.732 0 0
Ion homeostasis R-HSA-5578775 4.733440e-01 0.325 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.084266e-01 0.681 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.485283e-01 0.605 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 2.243519e-01 0.649 1 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 3.633044e-01 0.440 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 2.243519e-01 0.649 1 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 2.243519e-01 0.649 1 0
RIPK1-mediated regulated necrosis R-HSA-5213460 4.810955e-01 0.318 0 0
FLT3 signaling in disease R-HSA-9682385 4.423730e-01 0.354 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 3.486483e-01 0.458 1 0
Signaling by ALK R-HSA-201556 3.263667e-01 0.486 0 0
Glycolysis R-HSA-70171 3.409253e-01 0.467 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 2.698855e-01 0.569 0 0
Regulation of KIT signaling R-HSA-1433559 2.767572e-01 0.558 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 4.562778e-01 0.341 0 0
Trafficking of AMPA receptors R-HSA-399719 1.778913e-01 0.750 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 3.802706e-01 0.420 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 5.087940e-01 0.293 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 3.240844e-01 0.489 1 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 3.929741e-01 0.406 1 0
Sensory processing of sound R-HSA-9659379 3.905991e-01 0.408 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 4.156209e-01 0.381 0 0
Activation of ATR in response to replication stress R-HSA-176187 3.633044e-01 0.440 0 0
Maturation of nucleoprotein R-HSA-9683610 5.149268e-01 0.288 0 0
PTEN Regulation R-HSA-6807070 5.176423e-01 0.286 0 0
Unfolded Protein Response (UPR) R-HSA-381119 1.756445e-01 0.755 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.956086e-01 0.709 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.496372e-01 0.603 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.440443e-01 0.463 0 0
Interleukin-38 signaling R-HSA-9007892 4.562778e-01 0.341 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 5.087940e-01 0.293 0 0
Inositol phosphate metabolism R-HSA-1483249 4.914745e-01 0.308 0 0
Influenza Infection R-HSA-168255 3.646245e-01 0.438 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.440443e-01 0.463 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 4.133577e-01 0.384 0 0
ChREBP activates metabolic gene expression R-HSA-163765 4.156209e-01 0.381 0 0
Uptake and function of anthrax toxins R-HSA-5210891 3.863629e-01 0.413 1 1
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 5.087940e-01 0.293 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 4.499265e-01 0.347 0 0
tRNA processing in the nucleus R-HSA-6784531 4.173151e-01 0.380 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.078537e-01 0.682 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 4.085037e-01 0.389 1 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 2.084266e-01 0.681 0 0
NOD1/2 Signaling Pathway R-HSA-168638 4.029921e-01 0.395 0 0
Signaling by Leptin R-HSA-2586552 3.802706e-01 0.420 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 3.802706e-01 0.420 0 0
Insulin processing R-HSA-264876 4.308959e-01 0.366 0 0
Interleukin-12 family signaling R-HSA-447115 2.744561e-01 0.562 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 5.372937e-01 0.270 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 5.372937e-01 0.270 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 5.385706e-01 0.269 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 5.408935e-01 0.267 0 0
FGFR2 alternative splicing R-HSA-6803529 5.408935e-01 0.267 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 5.408935e-01 0.267 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 5.408935e-01 0.267 0 0
Removal of the Flap Intermediate R-HSA-69166 5.454636e-01 0.263 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 5.454636e-01 0.263 0 0
CRMPs in Sema3A signaling R-HSA-399956 5.454636e-01 0.263 0 0
NRIF signals cell death from the nucleus R-HSA-205043 5.454636e-01 0.263 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 5.479886e-01 0.261 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 5.483628e-01 0.261 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 5.489429e-01 0.260 0 0
Neutrophil degranulation R-HSA-6798695 5.509613e-01 0.259 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 5.514800e-01 0.258 0 0
PLC beta mediated events R-HSA-112043 5.514800e-01 0.258 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 5.562406e-01 0.255 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 5.562406e-01 0.255 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.562406e-01 0.255 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 5.562406e-01 0.255 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 5.562406e-01 0.255 0 0
Phosphorylation of Emi1 R-HSA-176417 5.562406e-01 0.255 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.562406e-01 0.255 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 5.562406e-01 0.255 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 5.562406e-01 0.255 0 0
Signaling by MAPK mutants R-HSA-9652817 5.562406e-01 0.255 0 0
Signaling by RNF43 mutants R-HSA-5340588 5.562406e-01 0.255 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 5.562406e-01 0.255 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 5.562406e-01 0.255 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.562406e-01 0.255 0 0
TRAIL signaling R-HSA-75158 5.562406e-01 0.255 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 5.562406e-01 0.255 0 0
PKB-mediated events R-HSA-109703 5.562406e-01 0.255 0 0
PDE3B signalling R-HSA-165160 5.562406e-01 0.255 0 0
Synthesis of dolichyl-phosphate mannose R-HSA-162699 5.562406e-01 0.255 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 5.562406e-01 0.255 0 0
Synthesis of PS R-HSA-1483101 5.562406e-01 0.255 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 5.562406e-01 0.255 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 5.562406e-01 0.255 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.562406e-01 0.255 0 0
Diseases of Base Excision Repair R-HSA-9605308 5.562406e-01 0.255 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 5.562406e-01 0.255 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 5.562406e-01 0.255 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 5.562406e-01 0.255 0 0
Integrin signaling R-HSA-354192 5.588707e-01 0.253 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 5.588707e-01 0.253 0 0
FOXO-mediated transcription R-HSA-9614085 5.605627e-01 0.251 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 5.644515e-01 0.248 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 5.644515e-01 0.248 0 0
Syndecan interactions R-HSA-3000170 5.644515e-01 0.248 0 0
Heme signaling R-HSA-9707616 5.665156e-01 0.247 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 5.666518e-01 0.247 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 5.693096e-01 0.245 0 0
Glucose metabolism R-HSA-70326 5.701353e-01 0.244 0 0
Intracellular signaling by second messengers R-HSA-9006925 5.729117e-01 0.242 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 5.731484e-01 0.242 0 0
Depyrimidination R-HSA-73928 5.731484e-01 0.242 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 5.731484e-01 0.242 0 0
SHC1 events in EGFR signaling R-HSA-180336 5.746295e-01 0.241 0 0
G beta:gamma signalling through BTK R-HSA-8964315 5.746295e-01 0.241 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 5.746295e-01 0.241 0 0
Telomere C-strand synthesis initiation R-HSA-174430 5.746295e-01 0.241 0 0
Spry regulation of FGF signaling R-HSA-1295596 5.746295e-01 0.241 0 0
Formation of the anterior neural plate R-HSA-9823739 5.746295e-01 0.241 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 5.746295e-01 0.241 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 5.746295e-01 0.241 0 0
Ca2+ pathway R-HSA-4086398 5.782963e-01 0.238 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 5.786776e-01 0.238 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 5.786776e-01 0.238 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 5.813152e-01 0.236 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 5.813152e-01 0.236 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 5.852410e-01 0.233 0 0
Regulation of PTEN stability and activity R-HSA-8948751 5.852410e-01 0.233 0 0
Protein folding R-HSA-391251 5.863175e-01 0.232 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 5.872552e-01 0.231 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 5.872552e-01 0.231 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 5.872552e-01 0.231 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 5.872552e-01 0.231 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 5.901192e-01 0.229 0 0
Signaling by NOTCH4 R-HSA-9013694 5.919676e-01 0.228 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 5.979660e-01 0.223 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 5.979660e-01 0.223 0 0
Cytokine Signaling in Immune system R-HSA-1280215 5.987059e-01 0.223 1 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 5.991068e-01 0.222 0 0
Signaling by LTK in cancer R-HSA-9842640 5.991068e-01 0.222 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 5.991068e-01 0.222 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 5.991068e-01 0.222 0 0
Erythropoietin activates STAT5 R-HSA-9027283 5.991068e-01 0.222 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 5.991068e-01 0.222 0 0
Autointegration results in viral DNA circles R-HSA-177539 5.991068e-01 0.222 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 5.991068e-01 0.222 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 5.991068e-01 0.222 0 0
Abacavir transmembrane transport R-HSA-2161517 5.991068e-01 0.222 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 5.991068e-01 0.222 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 5.991068e-01 0.222 0 0
HDL clearance R-HSA-8964011 5.991068e-01 0.222 0 0
Nef and signal transduction R-HSA-164944 5.991068e-01 0.222 0 0
Meiosis R-HSA-1500620 6.016010e-01 0.221 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 6.016010e-01 0.221 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 6.024047e-01 0.220 0 0
Prolonged ERK activation events R-HSA-169893 6.024047e-01 0.220 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 6.024047e-01 0.220 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 6.024047e-01 0.220 0 0
ER to Golgi Anterograde Transport R-HSA-199977 6.066969e-01 0.217 0 0
RMTs methylate histone arginines R-HSA-3214858 6.074936e-01 0.216 0 0
Interleukin-7 signaling R-HSA-1266695 6.092778e-01 0.215 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 6.141522e-01 0.212 0 0
Signaling by NOTCH3 R-HSA-9012852 6.161631e-01 0.210 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 6.161631e-01 0.210 0 0
Regulation of Apoptosis R-HSA-169911 6.167151e-01 0.210 0 0
PERK regulates gene expression R-HSA-381042 6.167151e-01 0.210 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 6.182599e-01 0.209 0 0
Opioid Signalling R-HSA-111885 6.186193e-01 0.209 0 0
Response of endothelial cells to shear stress R-HSA-9860931 6.186193e-01 0.209 0 0
Somitogenesis R-HSA-9824272 6.240550e-01 0.205 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 6.240550e-01 0.205 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 6.240550e-01 0.205 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 6.262656e-01 0.203 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 6.262656e-01 0.203 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 6.287855e-01 0.201 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.287855e-01 0.201 0 0
Coenzyme A biosynthesis R-HSA-196783 6.287855e-01 0.201 0 0
Synthesis of PG R-HSA-1483148 6.287855e-01 0.201 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 6.305002e-01 0.200 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 6.305002e-01 0.200 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 6.311269e-01 0.200 0 0
MHC class II antigen presentation R-HSA-2132295 6.334555e-01 0.198 0 0
Eukaryotic Translation Termination R-HSA-72764 6.338375e-01 0.198 0 0
PRC2 methylates histones and DNA R-HSA-212300 6.349080e-01 0.197 0 0
RET signaling R-HSA-8853659 6.349080e-01 0.197 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.378346e-01 0.195 0 0
DAG1 core M1 glycosylations R-HSA-8932506 6.378346e-01 0.195 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 6.378346e-01 0.195 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 6.378346e-01 0.195 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 6.378346e-01 0.195 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 6.378346e-01 0.195 0 0
PTK6 Expression R-HSA-8849473 6.378346e-01 0.195 0 0
TRIF-mediated programmed cell death R-HSA-2562578 6.378346e-01 0.195 0 0
Cysteine formation from homocysteine R-HSA-1614603 6.378346e-01 0.195 0 0
Reuptake of GABA R-HSA-888593 6.378346e-01 0.195 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.378346e-01 0.195 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 6.378346e-01 0.195 0 0
VLDL clearance R-HSA-8964046 6.378346e-01 0.195 0 0
Regulation of PTEN localization R-HSA-8948747 6.378346e-01 0.195 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 6.378346e-01 0.195 0 0
CHL1 interactions R-HSA-447041 6.378346e-01 0.195 0 0
Maturation of replicase proteins R-HSA-9694301 6.378346e-01 0.195 0 0
G-protein mediated events R-HSA-112040 6.378938e-01 0.195 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 6.401902e-01 0.194 0 0
Signaling by TGFBR3 R-HSA-9839373 6.401902e-01 0.194 0 0
Toll-like Receptor Cascades R-HSA-168898 6.431348e-01 0.192 1 0
Signaling by Interleukins R-HSA-449147 6.454275e-01 0.190 1 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 6.509103e-01 0.186 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 6.509103e-01 0.186 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 6.512482e-01 0.186 0 0
Regulated Necrosis R-HSA-5218859 6.513298e-01 0.186 0 0
Degradation of DVL R-HSA-4641258 6.525318e-01 0.185 0 0
Collagen chain trimerization R-HSA-8948216 6.525318e-01 0.185 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 6.528579e-01 0.185 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 6.537821e-01 0.185 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 6.537821e-01 0.185 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 6.537821e-01 0.185 0 0
Specification of primordial germ cells R-HSA-9827857 6.537821e-01 0.185 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 6.558879e-01 0.183 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 6.558879e-01 0.183 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 6.564734e-01 0.183 0 0
Platelet activation, signaling and aggregation R-HSA-76002 6.590423e-01 0.181 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 6.600054e-01 0.180 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 6.621619e-01 0.179 0 0
Gene Silencing by RNA R-HSA-211000 6.621619e-01 0.179 0 0
PIP3 activates AKT signaling R-HSA-1257604 6.628081e-01 0.179 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 6.705017e-01 0.174 0 0
Telomere Extension By Telomerase R-HSA-171319 6.705017e-01 0.174 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 6.705017e-01 0.174 0 0
Co-stimulation by CD28 R-HSA-389356 6.711394e-01 0.173 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 6.728231e-01 0.172 0 0
DAG1 core M2 glycosylations R-HSA-8932504 6.728231e-01 0.172 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 6.728231e-01 0.172 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 6.728231e-01 0.172 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 6.728231e-01 0.172 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 6.728231e-01 0.172 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 6.728231e-01 0.172 0 0
SLC-mediated bile acid transport R-HSA-9958517 6.728231e-01 0.172 0 0
Sodium/Proton exchangers R-HSA-425986 6.728231e-01 0.172 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 6.772935e-01 0.169 0 0
Polo-like kinase mediated events R-HSA-156711 6.774158e-01 0.169 0 0
PKA activation R-HSA-163615 6.774158e-01 0.169 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 6.774158e-01 0.169 0 0
PKA activation in glucagon signalling R-HSA-164378 6.774158e-01 0.169 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 6.774158e-01 0.169 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 6.774158e-01 0.169 0 0
Mitochondrial biogenesis R-HSA-1592230 6.775587e-01 0.169 0 0
G2/M Checkpoints R-HSA-69481 6.823781e-01 0.166 0 0
HCMV Early Events R-HSA-9609690 6.827454e-01 0.166 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 6.849161e-01 0.164 0 0
Gap junction trafficking and regulation R-HSA-157858 6.859381e-01 0.164 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 6.860382e-01 0.164 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 6.860382e-01 0.164 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 6.873117e-01 0.163 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 6.874317e-01 0.163 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 6.874317e-01 0.163 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 6.874317e-01 0.163 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 6.874317e-01 0.163 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 6.874317e-01 0.163 0 0
Signaling by Erythropoietin R-HSA-9006335 6.892738e-01 0.162 0 0
mRNA Capping R-HSA-72086 6.892738e-01 0.162 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 6.892738e-01 0.162 0 0
Platelet calcium homeostasis R-HSA-418360 6.892738e-01 0.162 0 0
Glucagon-type ligand receptors R-HSA-420092 6.892738e-01 0.162 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 6.898092e-01 0.161 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 6.898092e-01 0.161 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 6.997165e-01 0.155 0 0
Regulation of signaling by CBL R-HSA-912631 6.997165e-01 0.155 0 0
Translesion Synthesis by POLH R-HSA-110320 6.997165e-01 0.155 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 6.997165e-01 0.155 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.997165e-01 0.155 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 6.997165e-01 0.155 0 0
Diseases of hemostasis R-HSA-9671793 6.997165e-01 0.155 0 0
STING mediated induction of host immune responses R-HSA-1834941 6.997165e-01 0.155 0 0
Maturation of nucleoprotein R-HSA-9694631 6.997165e-01 0.155 0 0
Regulation of RAS by GAPs R-HSA-5658442 7.002793e-01 0.155 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 7.019115e-01 0.154 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 7.020081e-01 0.154 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 7.020081e-01 0.154 0 0
Cellular response to starvation R-HSA-9711097 7.042860e-01 0.152 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 7.044333e-01 0.152 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 7.044333e-01 0.152 0 0
Calcineurin activates NFAT R-HSA-2025928 7.044333e-01 0.152 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.044333e-01 0.152 0 0
mRNA Editing R-HSA-75072 7.044333e-01 0.152 0 0
ARMS-mediated activation R-HSA-170984 7.044333e-01 0.152 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.044333e-01 0.152 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.044333e-01 0.152 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 7.044333e-01 0.152 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 7.072304e-01 0.150 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 7.072304e-01 0.150 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.072304e-01 0.150 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 7.133623e-01 0.147 0 0
NCAM signaling for neurite out-growth R-HSA-375165 7.133623e-01 0.147 0 0
Cilium Assembly R-HSA-5617833 7.160616e-01 0.145 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 7.207212e-01 0.142 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 7.243796e-01 0.140 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 7.243796e-01 0.140 0 0
Budding and maturation of HIV virion R-HSA-162588 7.243796e-01 0.140 0 0
Downstream signal transduction R-HSA-186763 7.243796e-01 0.140 0 0
Potential therapeutics for SARS R-HSA-9679191 7.250263e-01 0.140 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 7.275800e-01 0.138 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 7.318965e-01 0.136 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 7.318965e-01 0.136 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 7.318965e-01 0.136 0 0
Degradation of CRY and PER proteins R-HSA-9932298 7.318965e-01 0.136 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 7.318965e-01 0.136 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 7.329911e-01 0.135 0 0
Binding and entry of HIV virion R-HSA-173107 7.329911e-01 0.135 0 0
Formation of intermediate mesoderm R-HSA-9761174 7.329911e-01 0.135 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 7.329911e-01 0.135 0 0
Regulation of the apoptosome activity R-HSA-9627069 7.329911e-01 0.135 0 0
Formation of apoptosome R-HSA-111458 7.329911e-01 0.135 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 7.333761e-01 0.135 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 7.373700e-01 0.132 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 7.377752e-01 0.132 0 0
G-protein activation R-HSA-202040 7.404721e-01 0.130 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 7.404721e-01 0.130 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.404721e-01 0.130 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 7.404721e-01 0.130 0 0
Signaling by WNT R-HSA-195721 7.446240e-01 0.128 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 7.460146e-01 0.127 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 7.462593e-01 0.127 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 7.471135e-01 0.127 0 0
Cellular response to hypoxia R-HSA-1234174 7.494110e-01 0.125 0 0
Organelle biogenesis and maintenance R-HSA-1852241 7.509450e-01 0.124 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 7.530396e-01 0.123 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 7.563053e-01 0.121 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 7.566054e-01 0.121 0 0
SARS-CoV-1-host interactions R-HSA-9692914 7.569060e-01 0.121 0 0
DAG1 core M3 glycosylations R-HSA-8932505 7.587912e-01 0.120 0 0
LGI-ADAM interactions R-HSA-5682910 7.587912e-01 0.120 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 7.587912e-01 0.120 0 0
vRNP Assembly R-HSA-192905 7.587912e-01 0.120 0 0
vRNA Synthesis R-HSA-192814 7.587912e-01 0.120 0 0
Bicarbonate transporters R-HSA-425381 7.587912e-01 0.120 0 0
Chylomicron assembly R-HSA-8963888 7.587912e-01 0.120 0 0
Suppression of apoptosis R-HSA-9635465 7.587912e-01 0.120 0 0
Prostanoid ligand receptors R-HSA-391908 7.587912e-01 0.120 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 7.588158e-01 0.120 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 7.590153e-01 0.120 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 7.590153e-01 0.120 0 0
Ribavirin ADME R-HSA-9755088 7.590153e-01 0.120 0 0
Defective pyroptosis R-HSA-9710421 7.595575e-01 0.119 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 7.595575e-01 0.119 0 0
Signaling by SCF-KIT R-HSA-1433557 7.595575e-01 0.119 0 0
SARS-CoV-2-host interactions R-HSA-9705683 7.656376e-01 0.116 0 0
Miscellaneous transport and binding events R-HSA-5223345 7.711137e-01 0.113 0 0
Gap junction trafficking R-HSA-190828 7.725333e-01 0.112 0 0
Signaling by NOTCH R-HSA-157118 7.740069e-01 0.111 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 7.755507e-01 0.110 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 7.763997e-01 0.110 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 7.763997e-01 0.110 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 7.763997e-01 0.110 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 7.763997e-01 0.110 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 7.820998e-01 0.107 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 7.820998e-01 0.107 0 0
Plasmalogen biosynthesis R-HSA-75896 7.820998e-01 0.107 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 7.820998e-01 0.107 0 0
NF-kB is activated and signals survival R-HSA-209560 7.820998e-01 0.107 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 7.820998e-01 0.107 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 7.820998e-01 0.107 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 7.820998e-01 0.107 0 0
Anchoring fibril formation R-HSA-2214320 7.820998e-01 0.107 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 7.820998e-01 0.107 0 0
Co-inhibition by PD-1 R-HSA-389948 7.839240e-01 0.106 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 7.849517e-01 0.105 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 7.849517e-01 0.105 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 7.849517e-01 0.105 0 0
Signal amplification R-HSA-392518 7.851774e-01 0.105 0 0
Signaling by NOTCH2 R-HSA-1980145 7.851774e-01 0.105 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 7.851774e-01 0.105 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 7.851774e-01 0.105 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 7.879804e-01 0.103 0 0
Signaling by NTRKs R-HSA-166520 7.907496e-01 0.102 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 7.926762e-01 0.101 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 7.926762e-01 0.101 0 0
Growth hormone receptor signaling R-HSA-982772 7.926762e-01 0.101 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 7.941236e-01 0.100 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 7.968234e-01 0.099 0 0
Processing of DNA double-strand break ends R-HSA-5693607 7.972820e-01 0.098 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 7.985177e-01 0.098 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 7.985415e-01 0.098 0 0
Selenocysteine synthesis R-HSA-2408557 8.003029e-01 0.097 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 8.031572e-01 0.095 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 8.031572e-01 0.095 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 8.031572e-01 0.095 0 0
Regulation of IFNG signaling R-HSA-877312 8.031572e-01 0.095 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.031572e-01 0.095 0 0
p75NTR recruits signalling complexes R-HSA-209543 8.031572e-01 0.095 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 8.031572e-01 0.095 0 0
VLDLR internalisation and degradation R-HSA-8866427 8.031572e-01 0.095 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 8.031572e-01 0.095 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.031572e-01 0.095 0 0
OAS antiviral response R-HSA-8983711 8.031572e-01 0.095 0 0
Interleukin-15 signaling R-HSA-8983432 8.031572e-01 0.095 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 8.036182e-01 0.095 0 0
Thromboxane signalling through TP receptor R-HSA-428930 8.078964e-01 0.093 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.078964e-01 0.093 0 0
Complex III assembly R-HSA-9865881 8.078964e-01 0.093 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 8.088226e-01 0.092 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.111569e-01 0.091 0 0
Hedgehog 'on' state R-HSA-5632684 8.113709e-01 0.091 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.149497e-01 0.089 0 0
Viral mRNA Translation R-HSA-192823 8.160513e-01 0.088 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 8.171702e-01 0.088 0 0
Ub-specific processing proteases R-HSA-5689880 8.172745e-01 0.088 0 0
GPER1 signaling R-HSA-9634597 8.189767e-01 0.087 0 0
Gluconeogenesis R-HSA-70263 8.189767e-01 0.087 0 0
G protein gated Potassium channels R-HSA-1296059 8.221124e-01 0.085 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 8.221124e-01 0.085 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 8.221124e-01 0.085 0 0
Tight junction interactions R-HSA-420029 8.221124e-01 0.085 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 8.221124e-01 0.085 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 8.221124e-01 0.085 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 8.221807e-01 0.085 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 8.221807e-01 0.085 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 8.221807e-01 0.085 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 8.221807e-01 0.085 0 0
Chylomicron remodeling R-HSA-8963901 8.221807e-01 0.085 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 8.221807e-01 0.085 0 0
CD28 dependent Vav1 pathway R-HSA-389359 8.221807e-01 0.085 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.221807e-01 0.085 0 0
Interleukin-6 signaling R-HSA-1059683 8.221807e-01 0.085 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.221807e-01 0.085 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 8.231186e-01 0.085 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.231186e-01 0.085 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 8.231186e-01 0.085 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 8.281272e-01 0.082 0 0
Formation of paraxial mesoderm R-HSA-9793380 8.281272e-01 0.082 0 0
SARS-CoV-1 Infection R-HSA-9678108 8.288523e-01 0.082 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 8.292851e-01 0.081 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 8.292851e-01 0.081 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 8.344125e-01 0.079 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 8.344269e-01 0.079 0 0
MET activates PTK2 signaling R-HSA-8874081 8.353761e-01 0.078 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 8.353761e-01 0.078 0 0
Metalloprotease DUBs R-HSA-5689901 8.353761e-01 0.078 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 8.353761e-01 0.078 0 0
TRP channels R-HSA-3295583 8.353761e-01 0.078 0 0
G2/M DNA damage checkpoint R-HSA-69473 8.375036e-01 0.077 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.393668e-01 0.076 0 0
Signaling by FGFR4 in disease R-HSA-5655291 8.393668e-01 0.076 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 8.393668e-01 0.076 0 0
Zinc transporters R-HSA-435354 8.393668e-01 0.076 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.393668e-01 0.076 0 0
Stabilization of p53 R-HSA-69541 8.451069e-01 0.073 0 0
Plasma lipoprotein clearance R-HSA-8964043 8.451069e-01 0.073 0 0
Packaging Of Telomere Ends R-HSA-171306 8.477388e-01 0.072 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 8.477388e-01 0.072 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 8.477388e-01 0.072 0 0
Cristae formation R-HSA-8949613 8.477388e-01 0.072 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 8.477388e-01 0.072 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 8.484380e-01 0.071 0 0
Hedgehog ligand biogenesis R-HSA-5358346 8.484380e-01 0.071 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 8.532454e-01 0.069 0 0
IGF1R signaling cascade R-HSA-2428924 8.540822e-01 0.069 0 0
Insulin receptor signalling cascade R-HSA-74751 8.540822e-01 0.069 0 0
Translesion synthesis by REV1 R-HSA-110312 8.548928e-01 0.068 0 0
p75NTR signals via NF-kB R-HSA-193639 8.548928e-01 0.068 0 0
Signaling by Activin R-HSA-1502540 8.548928e-01 0.068 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 8.548928e-01 0.068 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.548928e-01 0.068 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.548928e-01 0.068 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 8.548928e-01 0.068 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 8.548928e-01 0.068 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 8.548928e-01 0.068 0 0
DNA Damage Reversal R-HSA-73942 8.548928e-01 0.068 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 8.551507e-01 0.068 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 8.551834e-01 0.068 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 8.592506e-01 0.066 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 8.592506e-01 0.066 0 0
Pyrimidine salvage R-HSA-73614 8.592506e-01 0.066 0 0
Pyroptosis R-HSA-5620971 8.592506e-01 0.066 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 8.606350e-01 0.065 0 0
Ribosome-associated quality control R-HSA-9948299 8.606894e-01 0.065 0 0
Regulation of insulin secretion R-HSA-422356 8.619640e-01 0.065 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 8.619747e-01 0.065 0 0
Signaling by TGFB family members R-HSA-9006936 8.624885e-01 0.064 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 8.646819e-01 0.063 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 8.646819e-01 0.063 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 8.646819e-01 0.063 0 0
RNA Polymerase I Transcription R-HSA-73864 8.677144e-01 0.062 0 0
PCP/CE pathway R-HSA-4086400 8.677144e-01 0.062 0 0
Translesion synthesis by POLI R-HSA-5656121 8.689190e-01 0.061 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 8.689190e-01 0.061 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 8.689190e-01 0.061 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.689190e-01 0.061 0 0
Activation of the phototransduction cascade R-HSA-2485179 8.689190e-01 0.061 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 8.689190e-01 0.061 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 8.689190e-01 0.061 0 0
Attachment and Entry R-HSA-9678110 8.689190e-01 0.061 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 8.689190e-01 0.061 0 0
Atorvastatin ADME R-HSA-9754706 8.689190e-01 0.061 0 0
Differentiation of T cells R-HSA-9945266 8.689190e-01 0.061 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 8.689190e-01 0.061 0 0
TCR signaling R-HSA-202403 8.696939e-01 0.061 0 0
DNA methylation R-HSA-5334118 8.699606e-01 0.061 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 8.699606e-01 0.061 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 8.736274e-01 0.059 0 0
Signaling by FGFR1 in disease R-HSA-5655302 8.736274e-01 0.059 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 8.737381e-01 0.059 0 0
Reproduction R-HSA-1474165 8.738531e-01 0.059 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 8.741119e-01 0.058 0 0
Hedgehog 'off' state R-HSA-5610787 8.742810e-01 0.058 0 0
HCMV Infection R-HSA-9609646 8.751437e-01 0.058 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.763083e-01 0.057 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 8.766862e-01 0.057 0 0
SARS-CoV-2 Infection R-HSA-9694516 8.773567e-01 0.057 0 0
Signaling by FGFR2 R-HSA-5654738 8.809766e-01 0.055 0 0
Translesion synthesis by POLK R-HSA-5655862 8.815901e-01 0.055 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 8.815901e-01 0.055 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 8.815901e-01 0.055 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 8.815901e-01 0.055 0 0
Fibronectin matrix formation R-HSA-1566977 8.815901e-01 0.055 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 8.815901e-01 0.055 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 8.815901e-01 0.055 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 8.815901e-01 0.055 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 8.820450e-01 0.055 0 0
PI Metabolism R-HSA-1483255 8.856815e-01 0.053 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 8.862245e-01 0.052 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 8.871763e-01 0.052 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 8.891629e-01 0.051 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 8.891629e-01 0.051 0 0
Cargo concentration in the ER R-HSA-5694530 8.891629e-01 0.051 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 8.899592e-01 0.051 0 0
Signaling by FGFR4 R-HSA-5654743 8.899592e-01 0.051 0 0
rRNA processing R-HSA-72312 8.909699e-01 0.050 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 8.930370e-01 0.049 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 8.930370e-01 0.049 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 8.930370e-01 0.049 0 0
Sulfide oxidation to sulfate R-HSA-1614517 8.930370e-01 0.049 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 8.930370e-01 0.049 0 0
Choline catabolism R-HSA-6798163 8.930370e-01 0.049 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.930370e-01 0.049 0 0
IRS-mediated signalling R-HSA-112399 8.953036e-01 0.048 0 0
COPII-mediated vesicle transport R-HSA-204005 8.962398e-01 0.048 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 8.962398e-01 0.048 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 8.973944e-01 0.047 0 0
Amine ligand-binding receptors R-HSA-375280 8.973944e-01 0.047 0 0
Inwardly rectifying K+ channels R-HSA-1296065 8.977449e-01 0.047 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 8.977449e-01 0.047 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 8.977449e-01 0.047 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 8.999131e-01 0.046 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.009853e-01 0.045 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 9.033780e-01 0.044 0 0
Transport of connexons to the plasma membrane R-HSA-190872 9.033780e-01 0.044 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 9.033780e-01 0.044 0 0
Apoptotic factor-mediated response R-HSA-111471 9.033780e-01 0.044 0 0
Tie2 Signaling R-HSA-210993 9.033780e-01 0.044 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 9.033780e-01 0.044 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.043741e-01 0.044 0 0
Signaling by FGFR3 R-HSA-5654741 9.043741e-01 0.044 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 9.057041e-01 0.043 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 9.057041e-01 0.043 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 9.057041e-01 0.043 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 9.057041e-01 0.043 0 0
FGFR1 mutant receptor activation R-HSA-1839124 9.057041e-01 0.043 0 0
Integration of energy metabolism R-HSA-163685 9.063601e-01 0.043 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.077324e-01 0.042 0 0
Platelet homeostasis R-HSA-418346 9.104667e-01 0.041 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.109215e-01 0.041 0 0
SARS-CoV Infections R-HSA-9679506 9.110794e-01 0.040 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 9.127197e-01 0.040 0 0
Crosslinking of collagen fibrils R-HSA-2243919 9.127197e-01 0.040 0 0
Germ layer formation at gastrulation R-HSA-9754189 9.127197e-01 0.040 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.127197e-01 0.040 0 0
Pyrimidine biosynthesis R-HSA-500753 9.127197e-01 0.040 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 9.127197e-01 0.040 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 9.127197e-01 0.040 0 0
The NLRP3 inflammasome R-HSA-844456 9.127197e-01 0.040 0 0
Specification of the neural plate border R-HSA-9834899 9.127197e-01 0.040 0 0
HDL remodeling R-HSA-8964058 9.127197e-01 0.040 0 0
Other interleukin signaling R-HSA-449836 9.127197e-01 0.040 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.127197e-01 0.040 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 9.130809e-01 0.039 0 0
Resolution of D-Loop Structures R-HSA-5693537 9.130809e-01 0.039 0 0
Effects of PIP2 hydrolysis R-HSA-114508 9.130809e-01 0.039 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.130809e-01 0.039 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.130809e-01 0.039 0 0
RAB geranylgeranylation R-HSA-8873719 9.135616e-01 0.039 0 0
Signaling by Hedgehog R-HSA-5358351 9.142510e-01 0.039 0 0
Synthesis of PC R-HSA-1483191 9.170590e-01 0.038 0 0
Signaling by ERBB4 R-HSA-1236394 9.180958e-01 0.037 0 0
Signaling by FGFR in disease R-HSA-1226099 9.180958e-01 0.037 0 0
Aquaporin-mediated transport R-HSA-445717 9.189845e-01 0.037 0 0
Stimuli-sensing channels R-HSA-2672351 9.190149e-01 0.037 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 9.199133e-01 0.036 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 9.199133e-01 0.036 0 0
Hyaluronan metabolism R-HSA-2142845 9.199133e-01 0.036 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.199133e-01 0.036 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.199133e-01 0.036 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.199133e-01 0.036 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 9.211588e-01 0.036 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 9.211588e-01 0.036 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 9.211588e-01 0.036 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 9.211588e-01 0.036 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 9.211588e-01 0.036 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.211588e-01 0.036 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.211588e-01 0.036 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.211588e-01 0.036 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 9.211588e-01 0.036 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.215699e-01 0.035 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.228084e-01 0.035 0 0
NGF-stimulated transcription R-HSA-9031628 9.228084e-01 0.035 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.228816e-01 0.035 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.233509e-01 0.035 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.241006e-01 0.034 0 0
Signaling by PDGF R-HSA-186797 9.241006e-01 0.034 0 0
Interleukin-1 family signaling R-HSA-446652 9.252537e-01 0.034 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.262376e-01 0.033 0 0
Adipogenesis R-HSA-9843745 9.285989e-01 0.032 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.287823e-01 0.032 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.287823e-01 0.032 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.287823e-01 0.032 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.287823e-01 0.032 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.287823e-01 0.032 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.287823e-01 0.032 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.287823e-01 0.032 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 9.287823e-01 0.032 0 0
Basigin interactions R-HSA-210991 9.287823e-01 0.032 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.287823e-01 0.032 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 9.289242e-01 0.032 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 9.292761e-01 0.032 0 0
GPVI-mediated activation cascade R-HSA-114604 9.320882e-01 0.031 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.320882e-01 0.031 0 0
Glycosphingolipid transport R-HSA-9845576 9.320882e-01 0.031 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.320882e-01 0.031 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.320882e-01 0.031 0 0
PI3K Cascade R-HSA-109704 9.332261e-01 0.030 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.332261e-01 0.030 0 0
Ion transport by P-type ATPases R-HSA-936837 9.334693e-01 0.030 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.340220e-01 0.030 1 1
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.356691e-01 0.029 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.356691e-01 0.029 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.356691e-01 0.029 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.356691e-01 0.029 0 0
Attachment and Entry R-HSA-9694614 9.356691e-01 0.029 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.363539e-01 0.029 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.374975e-01 0.028 0 0
Degradation of AXIN R-HSA-4641257 9.374975e-01 0.028 0 0
Cleavage of the damaged purine R-HSA-110331 9.374975e-01 0.028 0 0
Metabolism of folate and pterines R-HSA-196757 9.374975e-01 0.028 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.379342e-01 0.028 0 0
The phototransduction cascade R-HSA-2514856 9.379342e-01 0.028 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.396335e-01 0.027 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.418903e-01 0.026 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 9.418903e-01 0.026 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.418903e-01 0.026 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.418903e-01 0.026 0 0
Signaling by KIT in disease R-HSA-9669938 9.418903e-01 0.026 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.418903e-01 0.026 0 0
LDL clearance R-HSA-8964038 9.418903e-01 0.026 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 9.423335e-01 0.026 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.423335e-01 0.026 0 0
Depurination R-HSA-73927 9.424962e-01 0.026 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.424962e-01 0.026 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 9.449363e-01 0.025 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 9.449363e-01 0.025 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 9.449363e-01 0.025 0 0
Interferon gamma signaling R-HSA-877300 9.453600e-01 0.024 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.457896e-01 0.024 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.471130e-01 0.024 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.471130e-01 0.024 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.475102e-01 0.023 0 0
Interleukin receptor SHC signaling R-HSA-912526 9.475102e-01 0.023 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.475102e-01 0.023 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.475102e-01 0.023 0 0
Carnitine shuttle R-HSA-200425 9.475102e-01 0.023 0 0
Formation of the ureteric bud R-HSA-9830674 9.475102e-01 0.023 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 9.487870e-01 0.023 0 0
Activation of HOX genes during differentiation R-HSA-5619507 9.487870e-01 0.023 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.491290e-01 0.023 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 9.513750e-01 0.022 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.513750e-01 0.022 0 0
Collagen formation R-HSA-1474290 9.518453e-01 0.021 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.525869e-01 0.021 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 9.525869e-01 0.021 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.525869e-01 0.021 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 9.525869e-01 0.021 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 9.525869e-01 0.021 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.525869e-01 0.021 0 0
Interleukin-6 family signaling R-HSA-6783589 9.525869e-01 0.021 0 0
G alpha (z) signalling events R-HSA-418597 9.538544e-01 0.021 0 0
Neddylation R-HSA-8951664 9.544137e-01 0.020 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.553077e-01 0.020 0 0
Maturation of spike protein R-HSA-9694548 9.553077e-01 0.020 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.556194e-01 0.020 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 9.556194e-01 0.020 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 9.571729e-01 0.019 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 9.571729e-01 0.019 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.571729e-01 0.019 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.571729e-01 0.019 0 0
Hyaluronan degradation R-HSA-2160916 9.571729e-01 0.019 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.571729e-01 0.019 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.571729e-01 0.019 0 0
Laminin interactions R-HSA-3000157 9.571729e-01 0.019 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.571729e-01 0.019 0 0
Signaling by FGFR1 R-HSA-5654736 9.571900e-01 0.019 0 0
Translation of Structural Proteins R-HSA-9683701 9.589349e-01 0.018 0 0
Urea cycle R-HSA-70635 9.613155e-01 0.017 0 0
Abacavir ADME R-HSA-2161522 9.613155e-01 0.017 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.613155e-01 0.017 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.613155e-01 0.017 0 0
Activation of GABAB receptors R-HSA-991365 9.622788e-01 0.017 0 0
GABA B receptor activation R-HSA-977444 9.622788e-01 0.017 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.622788e-01 0.017 0 0
Signaling by FGFR R-HSA-190236 9.644023e-01 0.016 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.650577e-01 0.015 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.650577e-01 0.015 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 9.650577e-01 0.015 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.650577e-01 0.015 0 0
Triglyceride biosynthesis R-HSA-75109 9.650577e-01 0.015 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 9.650577e-01 0.015 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.650577e-01 0.015 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.650577e-01 0.015 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.653603e-01 0.015 0 0
Peroxisomal protein import R-HSA-9033241 9.658899e-01 0.015 0 0
HCMV Late Events R-HSA-9610379 9.666792e-01 0.015 0 0
Proteasome assembly R-HSA-9907900 9.681988e-01 0.014 0 0
Surfactant metabolism R-HSA-5683826 9.681988e-01 0.014 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.683987e-01 0.014 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.684380e-01 0.014 0 0
Prednisone ADME R-HSA-9757110 9.684380e-01 0.014 0 0
Inflammasomes R-HSA-622312 9.684380e-01 0.014 0 0
ABC-family proteins mediated transport R-HSA-382556 9.685269e-01 0.014 0 0
ER-Phagosome pathway R-HSA-1236974 9.701458e-01 0.013 0 0
Collagen degradation R-HSA-1442490 9.707324e-01 0.013 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.708126e-01 0.013 0 0
Cellular response to chemical stress R-HSA-9711123 9.713992e-01 0.013 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 9.714915e-01 0.013 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.714915e-01 0.013 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.714915e-01 0.013 0 0
Neurotransmitter release cycle R-HSA-112310 9.720537e-01 0.012 0 0
Translation of Structural Proteins R-HSA-9694635 9.727785e-01 0.012 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.732185e-01 0.012 0 0
Diseases of DNA repair R-HSA-9675135 9.732185e-01 0.012 0 0
DAP12 signaling R-HSA-2424491 9.742498e-01 0.011 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.742498e-01 0.011 0 0
Neurotransmitter clearance R-HSA-112311 9.742498e-01 0.011 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.742498e-01 0.011 0 0
Viral Infection Pathways R-HSA-9824446 9.755278e-01 0.011 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.763962e-01 0.010 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 9.767413e-01 0.010 0 0
Signaling by Insulin receptor R-HSA-74752 9.771193e-01 0.010 0 0
Metal ion SLC transporters R-HSA-425410 9.774685e-01 0.010 0 0
Parasite infection R-HSA-9664407 9.777693e-01 0.010 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.777693e-01 0.010 0 0
Leishmania phagocytosis R-HSA-9664417 9.777693e-01 0.010 0 0
Adaptive Immune System R-HSA-1280218 9.782096e-01 0.010 0 0
Peptide hormone metabolism R-HSA-2980736 9.787019e-01 0.009 0 0
Transmission across Chemical Synapses R-HSA-112315 9.788614e-01 0.009 0 0
DAG1 glycosylations R-HSA-8931838 9.789919e-01 0.009 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.793409e-01 0.009 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.793409e-01 0.009 0 0
SLC transporter disorders R-HSA-5619102 9.800500e-01 0.009 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.801472e-01 0.009 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.810248e-01 0.008 0 0
Cardiogenesis R-HSA-9733709 9.810248e-01 0.008 0 0
Azathioprine ADME R-HSA-9748787 9.810621e-01 0.008 0 0
Cardiac conduction R-HSA-5576891 9.815985e-01 0.008 0 0
Meiotic recombination R-HSA-912446 9.826437e-01 0.008 0 0
Complex IV assembly R-HSA-9864848 9.826437e-01 0.008 0 0
Hemostasis R-HSA-109582 9.835074e-01 0.007 0 0
tRNA processing R-HSA-72306 9.838612e-01 0.007 0 0
Gap junction assembly R-HSA-190861 9.845199e-01 0.007 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 9.845199e-01 0.007 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 9.845199e-01 0.007 0 0
eNOS activation R-HSA-203615 9.845199e-01 0.007 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.845199e-01 0.007 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.845199e-01 0.007 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.852772e-01 0.006 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.854312e-01 0.006 0 0
Nucleotide biosynthesis R-HSA-8956320 9.854312e-01 0.006 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 9.860181e-01 0.006 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.860181e-01 0.006 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.860181e-01 0.006 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.860181e-01 0.006 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.860181e-01 0.006 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.868128e-01 0.006 0 0
Ion channel transport R-HSA-983712 9.882734e-01 0.005 0 0
Interleukin-1 signaling R-HSA-9020702 9.884713e-01 0.005 0 0
Selenoamino acid metabolism R-HSA-2408522 9.885104e-01 0.005 0 0
Voltage gated Potassium channels R-HSA-1296072 9.885939e-01 0.005 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.885939e-01 0.005 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 9.896980e-01 0.004 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.896980e-01 0.004 0 0
Purine salvage R-HSA-74217 9.896980e-01 0.004 0 0
Synthesis of PA R-HSA-1483166 9.897598e-01 0.004 0 0
Protein localization R-HSA-9609507 9.900560e-01 0.004 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.902069e-01 0.004 0 0
Iron uptake and transport R-HSA-917937 9.902957e-01 0.004 0 0
RAS processing R-HSA-9648002 9.906954e-01 0.004 0 0
Pentose phosphate pathway R-HSA-71336 9.906954e-01 0.004 0 0
RSV-host interactions R-HSA-9833110 9.913009e-01 0.004 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 9.915962e-01 0.004 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 9.915962e-01 0.004 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.915962e-01 0.004 0 0
Diseases of Immune System R-HSA-5260271 9.915962e-01 0.004 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.915962e-01 0.004 0 0
Interleukin-2 family signaling R-HSA-451927 9.915962e-01 0.004 0 0
Glycogen metabolism R-HSA-8982491 9.915962e-01 0.004 0 0
GABA receptor activation R-HSA-977443 9.921545e-01 0.003 0 0
Metabolism of polyamines R-HSA-351202 9.921545e-01 0.003 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.921861e-01 0.003 0 0
ABC transporter disorders R-HSA-5619084 9.923886e-01 0.003 0 0
Integrin cell surface interactions R-HSA-216083 9.923886e-01 0.003 0 0
Cholesterol biosynthesis R-HSA-191273 9.923886e-01 0.003 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.924099e-01 0.003 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.927560e-01 0.003 0 0
Nucleotide salvage R-HSA-8956321 9.928236e-01 0.003 0 0
Intra-Golgi traffic R-HSA-6811438 9.931448e-01 0.003 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.931448e-01 0.003 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.932859e-01 0.003 0 0
Mitochondrial protein import R-HSA-1268020 9.934368e-01 0.003 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.934614e-01 0.003 0 0
Formation of the cornified envelope R-HSA-6809371 9.946532e-01 0.002 0 0
Parasitic Infection Pathways R-HSA-9824443 9.947536e-01 0.002 0 0
Leishmania infection R-HSA-9658195 9.947536e-01 0.002 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.949445e-01 0.002 0 0
DAP12 interactions R-HSA-2172127 9.949497e-01 0.002 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.949497e-01 0.002 0 0
Methylation R-HSA-156581 9.949497e-01 0.002 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.949497e-01 0.002 0 0
Immune System R-HSA-168256 9.952702e-01 0.002 1 0
Fanconi Anemia Pathway R-HSA-6783310 9.954388e-01 0.002 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.954388e-01 0.002 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.958806e-01 0.002 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.958806e-01 0.002 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 9.962796e-01 0.002 0 0
Intraflagellar transport R-HSA-5620924 9.966400e-01 0.001 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.967698e-01 0.001 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.968055e-01 0.001 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.969739e-01 0.001 0 0
Extracellular matrix organization R-HSA-1474244 9.970529e-01 0.001 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.970823e-01 0.001 0 0
ECM proteoglycans R-HSA-3000178 9.970823e-01 0.001 0 0
Neuronal System R-HSA-112316 9.972469e-01 0.001 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.972594e-01 0.001 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.973462e-01 0.001 0 0
Downstream TCR signaling R-HSA-202424 9.973995e-01 0.001 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.975250e-01 0.001 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.975374e-01 0.001 1 0
Disorders of transmembrane transporters R-HSA-5619115 9.980245e-01 0.001 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.984587e-01 0.001 0 0
Interleukin-10 signaling R-HSA-6783783 9.984587e-01 0.001 0 0
PPARA activates gene expression R-HSA-1989781 9.986529e-01 0.001 0 0
Potassium Channels R-HSA-1296071 9.986769e-01 0.001 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 9.986769e-01 0.001 0 0
Phospholipid metabolism R-HSA-1483257 9.987084e-01 0.001 0 0
G alpha (s) signalling events R-HSA-418555 9.988101e-01 0.001 0 0
Amyloid fiber formation R-HSA-977225 9.988295e-01 0.001 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.988843e-01 0.000 0 0
Triglyceride metabolism R-HSA-8979227 9.989050e-01 0.000 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.989050e-01 0.000 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.990111e-01 0.000 0 0
Translation R-HSA-72766 9.990159e-01 0.000 0 0
Interferon alpha/beta signaling R-HSA-909733 9.990585e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.992717e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.993270e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.993865e-01 0.000 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.995157e-01 0.000 0 0
Kidney development R-HSA-9830369 9.995157e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.996229e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.996780e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.996780e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.997092e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.997652e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.997859e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.998840e-01 0.000 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.998844e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.998956e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999011e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999011e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999530e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999562e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999645e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999724e-01 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 9.999749e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999815e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999844e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999844e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999863e-01 0.000 1 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999864e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.999897e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999909e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.999912e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.999919e-01 0.000 1 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999926e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999935e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999940e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999951e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999960e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999963e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999964e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999966e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999967e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.999981e-01 0.000 0 0
Disease R-HSA-1643685 9.999987e-01 0.000 1 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999991e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999991e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999995e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999996e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999997e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999997e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999998e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999998e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999998e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 1 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways