MAP2K6

TYR version of PSPA with Y as phospho-acceptor
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Y Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Log-Odds: Y Sites / Y Background
Sites with acceptor types representing >8% and count ≥10 are included
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Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
A5A3E0 Y940 Sugiyama POTEF A26C1B ALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPEA
O00165 S153 Sugiyama HAX1 HS1BP1 PDSHQPRIFGGVLESDARSEsPQPAPDWGsQRPFHRFDDVW
O14545 S327 Sugiyama TRAFD1 FLN29 DHQTSCNPSRALPsLNtGsssPRGVEEPDVIFQNFLQQAAS
O15264 T180 GPS6|SIGNOR|EPSD|PSP MAPK13 PRKM13 SAPK4 EDCELKILDFGLARHADAEMtGyVVtRWYRAPEVILSWMHY
O15264 Y182 SIGNOR|PSP MAPK13 PRKM13 SAPK4 CELKILDFGLARHADAEMtGyVVtRWYRAPEVILSWMHYNQ
O60361 Y136 Sugiyama NME2P1 SLRFKPEELVDYKSCAHDWVyE___________________
O60716 S252 Sugiyama CTNND1 KIAA0384 sRVtRIEERyRPsMEGyRAPsRQDVyGPQPQVRVGGssVDL
P00558 T168 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 EAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGF
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P07195 S320 Sugiyama LDHB GLtsVINQKLKDDEVAQLKKsADtLWDIQKDLKDL______
P07205 T168 Sugiyama PGK2 PGKB EAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNLPHKASGF
P07237 Y94 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB GSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFFRNGDTASPK
P07900 S52 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P07900 Y309 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA ELNKtKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHF
P08238 Y305 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB tKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEG
P17812 S575 Sugiyama CTPS1 CTPS LQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD____
P18621 S5 Sugiyama RPL17 ________________MVRysLDPENPtKsCKSRGSNLRVH
P22392 Y151 Sugiyama NME2 NM23B SLWFKPEELVDyKSCAHDWVyE___________________
P23434 Y139 Sugiyama GCSH EVTEINEALAENPGLVNKSCyEDGWLIKMtLsNPsELDELM
P25398 Y127 Sugiyama RPS12 sCVVVKDYGKESQAKDVIEEyFKCKK_______________
P26038 S576 Sugiyama MSN YKtLRQIRQGNTKQRIDEFEsM___________________
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P31943 Y266 Sugiyama HNRNPH1 HNRPH HNRPH1 yNGYNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGstFQst
P37802 T180 Sugiyama TAGLN2 KIAA0120 CDABP0035 RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P40818 S719 Sugiyama USP8 KIAA0055 UBPY KPQIPAERDREPSKLKRsyssPDItQAIQEEEKRKPTVtPT
P42166 T160 Sugiyama TMPO LAP2 KLYEKKLLKLREQGtEsRsstPLPtIsssAENtRQNGsNDs
P42167 T160 Sugiyama TMPO LAP2 KLYEKKLLKLREQGTESRsstPLPTISsSAENTRQNGSNDS
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P52564 S207 EPSD|PSP MAP2K6 MEK6 MKK6 PRKMK6 SKK3 INALGQVKMCDFGISGyLVDsVAKtIDAGCKPyMAPERINP
P52564 S26 Sugiyama MAP2K6 MEK6 MKK6 PRKMK6 SKK3 GKKRNPGLKIPKEAFEQPQtsstPPRDLDsKACISIGNQNF
P52564 S27 Sugiyama MAP2K6 MEK6 MKK6 PRKMK6 SKK3 KKRNPGLKIPKEAFEQPQtsstPPRDLDsKACISIGNQNFE
P52564 T25 Sugiyama MAP2K6 MEK6 MKK6 PRKMK6 SKK3 KGKKRNPGLKIPKEAFEQPQtsstPPRDLDsKACISIGNQN
P52564 T28 Sugiyama MAP2K6 MEK6 MKK6 PRKMK6 SKK3 KRNPGLKIPKEAFEQPQtsstPPRDLDsKACISIGNQNFEV
P52564 Y219 EPSD|PSP MAP2K6 MEK6 MKK6 PRKMK6 SKK3 GISGyLVDsVAKtIDAGCKPyMAPERINPELNQKGYSVKSD
P53778 T183 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP MAPK12 ERK6 SAPK3 EDCELKILDFGLARQADsEMtGyVVtRWYRAPEVILNWMRY
P53778 Y185 SIGNOR|ELM|iPTMNet|EPSD|PSP MAPK12 ERK6 SAPK3 CELKILDFGLARQADsEMtGyVVtRWYRAPEVILNWMRYTQ
P55795 Y266 Sugiyama HNRNPH2 FTP3 HNRPH2 YGGYNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGssFQst
P60174 Y209 Sugiyama TPI1 TPI LRGWLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDG
P60709 Y240 Sugiyama ACTB ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62736 Y242 Sugiyama ACTA2 ACTSA ACTVS GIG46 ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P63220 Y53 Sugiyama RPS21 QMNVAEVDKVTGRFNGQFKtyAICGAIRRMGEsDDsILRLA
P63261 Y240 Sugiyama ACTG1 ACTG ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P63267 Y241 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68032 Y242 Sugiyama ACTC1 ACTC ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68133 Y242 Sugiyama ACTA1 ACTA ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
Q00613 S363 Sugiyama HSF1 HSTF1 AsVTALtDARGHTDtEGRPPsPPPtstPEKCLsVACLDKNE
Q01518 T165 Sugiyama CAP1 CAP AMAPKPGPYVKEMNDAAMFytNRVLKEYKDVDKKHVDWVKA
Q06830 Y116 Sugiyama PRDX1 PAGA PAGB TDPX2 GLGPMNIPLVSDPKRtIAQDyGVLKADEGIsFRGLFIIDDK
Q12913 S843 Sugiyama PTPRJ DEP1 PNITSVSHNSVKVKFSGFEAsHGPIKAYAVILTTGEAGHPS
Q13247 S303 Sugiyama SRSF6 SFRS6 SRP55 ENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsPPPKRAT
Q13283 S232 Sugiyama G3BP1 G3BP EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q14152 S988 Sugiyama EIF3A EIF3S10 KIAA0139 PRRGPEEDRFsRRGADDDRPsWRNTDDDRPPRRIADEDRGN
Q14568 S52 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q14765 S721 SIGNOR|iPTMNet|EPSD STAT4 ISTIRSDSTEPHsPSDLLPMsPSVYAVLRENLsPTTIETAM
Q15080 S67 Sugiyama NCF4 SH3PXD4 TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q15637 S82 Sugiyama SF1 ZFM1 ZNF162 TRKLRtGDLGIPPNPEDRsPsPEPIyNsEGKRLNTREFRTR
Q15759 T180 GPS6|EPSD MAPK11 PRKM11 SAPK2 SAPK2B EDCELRILDFGLARQADEEMtGyVAtRWYRAPEIMLNWMHY
Q15759 Y182 EPSD MAPK11 PRKM11 SAPK2 SAPK2B CELRILDFGLARQADEEMtGyVAtRWYRAPEIMLNWMHYNQ
Q16539 T180 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A EDCELKILDFGLARHtDDEMtGyVAtRWYRAPEIMLNWMHY
Q16539 Y182 SIGNOR|iPTMNet|EPSD|PSP MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A CELKILDFGLARHtDDEMtGyVAtRWYRAPEIMLNWMHYNQ
Q562R1 Y241 Sugiyama ACTBL2 ALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPEA
Q6GYQ0 T1002 Sugiyama RALGAPA1 GARNL1 KIAA0884 TULIP1 TITGSESASPVHSPLGSRsQtPsPSTLNIDHMEQKDLQLDE
Q6S8J3 Y940 Sugiyama POTEE A26C1A POTE2 ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
Q6UN15 S492 Sugiyama FIP1L1 FIP1 RHE DRDRDRERERTRERERERDHsPtPsVFNsDEERyRYREYAE
Q7L2J0 S216 Sugiyama MEPCE BCDIN3 NLNSLLDEEVSRtLNAEtPKssPLPAKGRDPVEILIPKDIt
Q7L2J0 T213 Sugiyama MEPCE BCDIN3 DPLNLNSLLDEEVSRtLNAEtPKssPLPAKGRDPVEILIPK
Q7Z2W4 T273 Sugiyama ZC3HAV1 ZC3HDC2 PRO1677 FFQGsQEFLASASAsAERsCtPsPDQIsHRAsLEDAPVDDL
Q8IWX8 S817 Sugiyama CHERP DAN26 SCAF6 QSRSRSKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIPDS
Q8IWX8 T819 Sugiyama CHERP DAN26 SCAF6 RSRSKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIPDSRL
Q8N684 T203 Sugiyama CPSF7 GGIPPRAHsRDssDsADGRAtPsENLVPSSARVDKPPSVLP
Q8TAM6 S280 Sugiyama ERMN KIAA1189 TISYRKIRKGNTKQRIDEFEsMMHL________________
Q96CT7 Y38 Sugiyama CCDC124 RRAEAKAAADAKKQKELEDAyWKDDDKHVMRKEQRKEEKEK
Q96MU7 S308 Sugiyama YTHDC1 KIAA1966 YT521 GSGTDGsDEKKKERKRARGIsPIVFDRsGssAsESYAGsEK
Q96S44 T8 Sugiyama TP53RK C20orf64 PRPK _____________MAAARAttPADGEEPAPEAEALAAARER
Q99759 S337 Sugiyama MAP3K3 MAPKKK3 MEKK3 tNGENMGLAVQYLDPRGRLRsADsENALsVQERNVPTKsPs
Q9BYX7 Y240 Sugiyama POTEKP ACTBL3 FKSG30 ALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPEA
Q9H7N4 S498 Sugiyama SCAF1 SFRS19 SRA1 GGLDLRRKILTQRRERyRQRsPsPAPAPAPAAAAGPPTRKK
Q9H7N4 S500 Sugiyama SCAF1 SFRS19 SRA1 LDLRRKILTQRRERyRQRsPsPAPAPAPAAAAGPPTRKKSR
Q9NQU5 T564 GPS6|ELM|iPTMNet|EPSD PAK6 PAK5 DFGFCAQISKDVPKRKsLVGtPyWMAPEVISRSLYATEVDI
Q9NQU5 Y566 SIGNOR|ELM|iPTMNet|EPSD|PSP PAK6 PAK5 GFCAQISKDVPKRKsLVGtPyWMAPEVISRSLYATEVDIWS
Q9NWB6 S77 Sugiyama ARGLU1 RsRstNTAVSRRERDRERAssPPDRIDIFGRTVSKRSSLDE
Q9ULV5 T471 SIGNOR|EPSD|PSP HSF4 LLLDVQAALGGPALGLPGALtIYSTPESRTASYLGPEASPS
Q9UQ35 S1103 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 sPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEFsA
Q9UQ35 S2046 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 IRRRsRsRtPLLPRKRsRsRsPLAIRRRSRSRTPRTARGKR
Q9UQ35 S2132 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 SRMsCFsRPsMsPtPLDRCRsPGMLEPLGssRtPMsVLQQA
Q9Y2V2 S30 Sugiyama CARHSP1 QPPtHQAsVGLLDtPRsRERsPsPLRGNVVPsPLPtRRtRt
Q9Y2V2 S32 Sugiyama CARHSP1 PtHQAsVGLLDtPRsRERsPsPLRGNVVPsPLPtRRtRtFs
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Apoptotic cleavage of cellular proteins R-HSA-111465 1.538615e-09 8.813 0 0
Apoptotic execution phase R-HSA-75153 2.289584e-08 7.640 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 4.614512e-08 7.336 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.719480e-07 6.566 0 0
mRNA Splicing R-HSA-72172 4.606999e-07 6.337 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 7.428548e-07 6.129 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 8.712242e-06 5.060 0 0
Formation of the cornified envelope R-HSA-6809371 2.327109e-05 4.633 0 0
Apoptosis R-HSA-109581 1.458575e-04 3.836 0 0
Keratinization R-HSA-6805567 6.560186e-04 3.183 0 0
Programmed Cell Death R-HSA-5357801 6.375265e-04 3.196 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 8.198915e-04 3.086 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.105497e-03 2.677 0 0
Cell-Cell communication R-HSA-1500931 2.112253e-03 2.675 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.105497e-03 2.677 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.256210e-03 2.487 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.916367e-03 2.407 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 4.397924e-03 2.357 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 4.635586e-03 2.334 0 0
Regulation of CDH11 function R-HSA-9762292 5.410963e-03 2.267 0 0
Metabolism of RNA R-HSA-8953854 5.246573e-03 2.280 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 6.919446e-03 2.160 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.650615e-02 1.782 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.650615e-02 1.782 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.650615e-02 1.782 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.650615e-02 1.782 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.650615e-02 1.782 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.650615e-02 1.782 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.650615e-02 1.782 0 0
Regulation of signaling by CBL R-HSA-912631 1.737861e-02 1.760 0 0
HDACs deacetylate histones R-HSA-3214815 1.605809e-02 1.794 0 0
Cell junction organization R-HSA-446728 1.275606e-02 1.894 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.604669e-02 1.795 0 0
Signaling by Hippo R-HSA-2028269 1.476094e-02 1.831 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.745152e-02 1.758 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.960101e-02 1.708 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 2.164301e-02 1.665 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.164301e-02 1.665 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 2.465753e-02 1.608 0 0
FGFR2 alternative splicing R-HSA-6803529 2.315129e-02 1.635 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.328218e-02 1.633 0 0
Deadenylation of mRNA R-HSA-429947 2.629326e-02 1.580 0 0
Cell-cell junction organization R-HSA-421270 2.644486e-02 1.578 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.523609e-02 1.598 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 2.792537e-02 1.554 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 2.792537e-02 1.554 0 0
Chromatin organization R-HSA-4839726 2.563093e-02 1.591 0 0
Signaling by VEGF R-HSA-194138 3.015461e-02 1.521 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 3.130802e-02 1.504 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 3.130802e-02 1.504 0 0
HIV elongation arrest and recovery R-HSA-167287 3.305704e-02 1.481 0 0
Pausing and recovery of HIV elongation R-HSA-167290 3.305704e-02 1.481 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 5.659790e-02 1.247 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 6.441941e-02 1.191 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 6.441941e-02 1.191 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 6.441941e-02 1.191 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 6.441941e-02 1.191 0 0
Chylomicron clearance R-HSA-8964026 7.217655e-02 1.142 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 7.217655e-02 1.142 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 7.217655e-02 1.142 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 7.217655e-02 1.142 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 7.986985e-02 1.098 0 0
Type I hemidesmosome assembly R-HSA-446107 8.749984e-02 1.058 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.025719e-01 0.989 0 0
Maple Syrup Urine Disease R-HSA-9865114 1.247179e-01 0.904 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.247179e-01 0.904 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.319787e-01 0.879 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 1.391797e-01 0.856 0 0
Erythropoietin activates RAS R-HSA-9027284 1.463214e-01 0.835 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.463214e-01 0.835 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.534043e-01 0.814 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.673956e-01 0.776 0 0
Ephrin signaling R-HSA-3928664 1.743049e-01 0.759 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 5.894760e-02 1.230 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 5.894760e-02 1.230 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 1.811573e-01 0.742 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.811573e-01 0.742 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.879533e-01 0.726 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.879533e-01 0.726 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.879533e-01 0.726 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.879533e-01 0.726 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 1.946933e-01 0.711 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 7.498891e-02 1.125 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 2.013777e-01 0.696 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 2.145819e-01 0.668 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 2.145819e-01 0.668 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 8.970336e-02 1.047 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 9.223329e-02 1.035 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 9.223329e-02 1.035 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 2.275693e-01 0.643 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 2.466518e-01 0.608 0 0
Formation of the Early Elongation Complex R-HSA-113418 2.466518e-01 0.608 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 2.529081e-01 0.597 0 0
Transcription of the HIV genome R-HSA-167172 1.323974e-01 0.878 0 0
EGFR downregulation R-HSA-182971 2.652663e-01 0.576 0 0
HIV Transcription Elongation R-HSA-167169 5.894760e-02 1.230 0 0
mRNA Capping R-HSA-72086 2.529081e-01 0.597 0 0
Activation of the pre-replicative complex R-HSA-68962 2.591128e-01 0.587 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 5.894760e-02 1.230 0 0
Nephrin family interactions R-HSA-373753 1.879533e-01 0.726 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.100150e-01 0.959 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 5.676583e-02 1.246 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 2.080071e-01 0.682 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 2.893774e-01 0.539 0 0
Regulation of gap junction activity R-HSA-191650 4.871149e-02 1.312 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 2.403435e-01 0.619 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 6.068111e-02 1.217 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 1.875861e-01 0.727 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 1.879533e-01 0.726 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.494149e-01 0.826 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 1.319787e-01 0.879 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 2.466518e-01 0.608 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 2.774217e-01 0.557 0 0
Generation of second messenger molecules R-HSA-202433 5.894760e-02 1.230 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 2.514253e-01 0.600 0 0
Activation of HOX genes during differentiation R-HSA-5619507 2.514253e-01 0.600 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.463214e-01 0.835 0 0
Integrin signaling R-HSA-354192 2.774217e-01 0.557 0 0
Resolution of D-Loop Structures R-HSA-5693537 2.834243e-01 0.548 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 2.339828e-01 0.631 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 6.441941e-02 1.191 0 0
Clathrin-mediated endocytosis R-HSA-8856828 4.628907e-02 1.335 0 0
Neutrophil degranulation R-HSA-6798695 2.089618e-01 0.680 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 2.774217e-01 0.557 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 6.115806e-02 1.214 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 1.946933e-01 0.711 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.408497e-01 0.851 0 0
Regulation of CDH1 Function R-HSA-9764561 1.025554e-01 0.989 0 0
DAP12 signaling R-HSA-2424491 2.591128e-01 0.587 0 0
Heme signaling R-HSA-9707616 1.158762e-01 0.936 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 4.871149e-02 1.312 0 0
Unwinding of DNA R-HSA-176974 9.506702e-02 1.022 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.173969e-01 0.930 0 0
NF-kB is activated and signals survival R-HSA-209560 1.173969e-01 0.930 0 0
PKA activation R-HSA-163615 1.743049e-01 0.759 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 1.743049e-01 0.759 0 0
PKA activation in glucagon signalling R-HSA-164378 1.743049e-01 0.759 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 1.811573e-01 0.742 0 0
Notch-HLH transcription pathway R-HSA-350054 2.080071e-01 0.682 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 2.893774e-01 0.539 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 2.893774e-01 0.539 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 2.339828e-01 0.631 0 0
LDL clearance R-HSA-8964038 2.080071e-01 0.682 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 2.591128e-01 0.587 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.266415e-01 0.897 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.743049e-01 0.759 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.408497e-01 0.851 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 2.834243e-01 0.548 0 0
Negative regulation of MET activity R-HSA-6807004 1.879533e-01 0.726 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.025719e-01 0.989 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 4.234980e-02 1.373 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 1.078308e-01 0.967 0 0
Diseases of mitotic cell cycle R-HSA-9675126 2.713692e-01 0.566 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.713223e-01 0.766 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 5.894760e-02 1.230 0 0
Diseases of Immune System R-HSA-5260271 5.894760e-02 1.230 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 2.466518e-01 0.608 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 2.529081e-01 0.597 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 2.893774e-01 0.539 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 1.173969e-01 0.930 0 0
Tight junction interactions R-HSA-420029 2.275693e-01 0.643 0 0
DARPP-32 events R-HSA-180024 2.529081e-01 0.597 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 2.774217e-01 0.557 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 2.893774e-01 0.539 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.668421e-01 0.778 0 0
Signaling by Erythropoietin R-HSA-9006335 2.529081e-01 0.597 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 7.980155e-02 1.098 0 0
Degradation of CDH1 R-HSA-9766229 8.224325e-02 1.085 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 9.506702e-02 1.022 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 2.952814e-01 0.530 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.463214e-01 0.835 0 0
TCR signaling R-HSA-202403 8.241968e-02 1.084 0 0
Adherens junctions interactions R-HSA-418990 4.958110e-02 1.305 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.078308e-01 0.967 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.056609e-01 0.976 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 6.441941e-02 1.191 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 8.749984e-02 1.058 0 0
Bicarbonate transporters R-HSA-425381 1.100150e-01 0.959 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.463214e-01 0.835 0 0
Negative regulation of FLT3 R-HSA-9706369 1.534043e-01 0.814 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 1.534043e-01 0.814 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 2.211024e-01 0.655 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.774217e-01 0.557 0 0
FLT3 signaling in disease R-HSA-9682385 5.039882e-02 1.298 0 0
Activation of ATR in response to replication stress R-HSA-176187 2.774217e-01 0.557 0 0
Kinesins R-HSA-983189 1.104954e-01 0.957 0 0
DNA Double Strand Break Response R-HSA-5693606 1.296069e-01 0.887 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.110122e-01 0.955 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.154222e-01 0.667 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.154222e-01 0.667 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 6.441941e-02 1.191 0 0
Pervasive developmental disorders R-HSA-9005895 1.247179e-01 0.904 0 0
Disorders of Nervous System Development R-HSA-9697154 1.247179e-01 0.904 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 1.247179e-01 0.904 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 7.189906e-02 1.143 0 0
Signaling by FGFR2 R-HSA-5654738 3.773863e-02 1.423 0 0
Membrane Trafficking R-HSA-199991 1.068836e-01 0.971 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 6.566252e-02 1.183 0 0
DNA Repair R-HSA-73894 2.108938e-01 0.676 0 0
Calmodulin induced events R-HSA-111933 3.011367e-01 0.521 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 1.247179e-01 0.904 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.391797e-01 0.856 0 0
Disorders of Developmental Biology R-HSA-9675151 1.604289e-01 0.795 0 0
Metalloprotease DUBs R-HSA-5689901 2.339828e-01 0.631 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 2.834243e-01 0.548 0 0
CaM pathway R-HSA-111997 3.011367e-01 0.521 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 2.086651e-01 0.681 0 0
Vesicle-mediated transport R-HSA-5653656 2.539546e-01 0.595 0 0
Frs2-mediated activation R-HSA-170968 1.319787e-01 0.879 0 0
p75NTR signals via NF-kB R-HSA-193639 1.463214e-01 0.835 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.025554e-01 0.989 0 0
Post NMDA receptor activation events R-HSA-438064 1.905794e-01 0.720 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 8.749984e-02 1.058 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 1.811573e-01 0.742 0 0
Rap1 signalling R-HSA-392517 1.811573e-01 0.742 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 1.879533e-01 0.726 0 0
Signaling by MET R-HSA-6806834 1.668421e-01 0.778 0 0
Neurodegenerative Diseases R-HSA-8863678 2.211024e-01 0.655 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.211024e-01 0.655 0 0
DNA strand elongation R-HSA-69190 2.713692e-01 0.566 0 0
Chromosome Maintenance R-HSA-73886 1.035792e-01 0.985 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.946933e-01 0.711 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.946933e-01 0.711 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 5.659790e-02 1.247 0 0
Regulation of KIT signaling R-HSA-1433559 1.391797e-01 0.856 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 1.811573e-01 0.742 0 0
mTORC1-mediated signalling R-HSA-166208 2.080071e-01 0.682 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 2.275693e-01 0.643 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 2.339828e-01 0.631 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 2.403435e-01 0.619 0 0
GPVI-mediated activation cascade R-HSA-114604 3.011367e-01 0.521 0 0
HDMs demethylate histones R-HSA-3214842 2.275693e-01 0.643 0 0
Triglyceride catabolism R-HSA-163560 3.011367e-01 0.521 0 0
Telomere Maintenance R-HSA-157579 2.269209e-01 0.644 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 7.962938e-02 1.099 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.875861e-01 0.727 0 0
HDL assembly R-HSA-8963896 1.391797e-01 0.856 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.713692e-01 0.566 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 6.203480e-02 1.207 0 0
Chromatin modifying enzymes R-HSA-3247509 6.198030e-02 1.208 0 0
Signaling by FGFR R-HSA-190236 6.340255e-02 1.198 0 0
Prolonged ERK activation events R-HSA-169893 1.534043e-01 0.814 0 0
Deubiquitination R-HSA-5688426 1.970446e-01 0.705 0 0
Signaling by FGFR in disease R-HSA-1226099 1.494149e-01 0.826 0 0
Signal regulatory protein family interactions R-HSA-391160 1.391797e-01 0.856 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 1.879533e-01 0.726 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 1.051840e-01 0.978 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 1.580824e-01 0.801 0 0
PKR-mediated signaling R-HSA-9833482 1.668421e-01 0.778 1 1
Cell Cycle R-HSA-1640170 2.621307e-01 0.581 0 0
Gene expression (Transcription) R-HSA-74160 6.418203e-02 1.193 1 0
SLC-mediated transport of inorganic anions R-HSA-9958790 5.461335e-02 1.263 0 0
Signaling by EGFR in Cancer R-HSA-1643713 2.339828e-01 0.631 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 1.743049e-01 0.759 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 2.211024e-01 0.655 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.733600e-01 0.761 0 0
RNA Polymerase II Transcription R-HSA-73857 2.589541e-01 0.587 1 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.422212e-01 0.616 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 2.652663e-01 0.576 0 0
Potential therapeutics for SARS R-HSA-9679191 5.255370e-02 1.279 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.483558e-01 0.605 0 0
Viral Infection Pathways R-HSA-9824446 2.477874e-01 0.606 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 1.247179e-01 0.904 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 2.893774e-01 0.539 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 3.011367e-01 0.521 0 0
Signaling by TGFB family members R-HSA-9006936 1.857282e-01 0.731 0 0
RSV-host interactions R-HSA-9833110 2.514253e-01 0.600 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 8.342176e-02 1.079 0 0
Infectious disease R-HSA-5663205 2.566357e-01 0.591 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.080071e-01 0.682 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.774217e-01 0.557 0 0
Signal Transduction R-HSA-162582 6.140476e-02 1.212 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.733600e-01 0.761 1 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 4.833807e-02 1.316 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 6.115806e-02 1.214 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 2.275693e-01 0.643 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 3.011367e-01 0.521 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.821449e-01 0.550 0 0
DNA Damage Reversal R-HSA-73942 1.463214e-01 0.835 0 0
Downstream signal transduction R-HSA-186763 2.652663e-01 0.576 0 0
Signalling to ERKs R-HSA-187687 2.952814e-01 0.530 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 1.436928e-01 0.843 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.673956e-01 0.776 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.673956e-01 0.776 0 0
FGFR2 mutant receptor activation R-HSA-1839126 3.011367e-01 0.521 0 0
PTEN Regulation R-HSA-6807070 1.416699e-01 0.849 0 0
Plasma lipoprotein assembly R-HSA-8963898 2.211024e-01 0.655 0 0
Interleukin-6 signaling R-HSA-1059683 1.319787e-01 0.879 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 2.952814e-01 0.530 0 0
RET signaling R-HSA-8853659 3.011367e-01 0.521 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.668421e-01 0.778 0 0
SARS-CoV-1-host interactions R-HSA-9692914 2.575673e-01 0.589 0 0
Regulation of TP53 Activity R-HSA-5633007 1.857282e-01 0.731 1 0
RNA Polymerase III Transcription R-HSA-74158 3.011367e-01 0.521 0 0
Generic Transcription Pathway R-HSA-212436 2.353063e-01 0.628 1 0
Regulation of TP53 Degradation R-HSA-6804757 3.011367e-01 0.521 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.121232e-01 0.950 1 0
Interleukin-6 family signaling R-HSA-6783589 2.211024e-01 0.655 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.240690e-01 0.906 0 0
SARS-CoV Infections R-HSA-9679506 2.051292e-01 0.688 0 0
Interleukin-12 signaling R-HSA-9020591 1.551825e-01 0.809 0 0
Interleukin-12 family signaling R-HSA-447115 1.905794e-01 0.720 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 3.036020e-01 0.518 1 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 3.036020e-01 0.518 1 0
Mitotic Prophase R-HSA-68875 3.066596e-01 0.513 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 3.069437e-01 0.513 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 3.127029e-01 0.505 0 0
MET promotes cell motility R-HSA-8875878 3.127029e-01 0.505 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 3.127673e-01 0.505 1 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 3.127673e-01 0.505 1 0
Mitotic Anaphase R-HSA-68882 3.134645e-01 0.504 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 3.157327e-01 0.501 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 3.158170e-01 0.501 0 0
MHC class II antigen presentation R-HSA-2132295 3.158170e-01 0.501 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 3.184145e-01 0.497 0 0
Plasma lipoprotein clearance R-HSA-8964043 3.184145e-01 0.497 0 0
RAS processing R-HSA-9648002 3.184145e-01 0.497 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 3.184145e-01 0.497 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 3.240790e-01 0.489 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 3.240790e-01 0.489 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 3.279849e-01 0.484 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 3.296968e-01 0.482 0 0
FLT3 Signaling R-HSA-9607240 3.296968e-01 0.482 0 0
PKMTs methylate histone lysines R-HSA-3214841 3.296968e-01 0.482 0 0
G2/M Checkpoints R-HSA-69481 3.310183e-01 0.480 0 0
Platelet degranulation R-HSA-114608 3.310183e-01 0.480 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 3.352683e-01 0.475 0 0
HIV Transcription Initiation R-HSA-167161 3.352683e-01 0.475 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 3.352683e-01 0.475 0 0
MAP2K and MAPK activation R-HSA-5674135 3.352683e-01 0.475 0 0
Signaling by RAF1 mutants R-HSA-9656223 3.352683e-01 0.475 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.352683e-01 0.475 0 0
Intra-Golgi traffic R-HSA-6811438 3.352683e-01 0.475 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 3.352683e-01 0.475 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 3.352683e-01 0.475 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 3.352683e-01 0.475 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 3.407938e-01 0.468 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 3.407938e-01 0.468 0 0
Ca-dependent events R-HSA-111996 3.407938e-01 0.468 0 0
MTOR signalling R-HSA-165159 3.407938e-01 0.468 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 3.462737e-01 0.461 0 0
Signaling by FGFR4 R-HSA-5654743 3.462737e-01 0.461 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 3.462737e-01 0.461 0 0
Signaling by SCF-KIT R-HSA-1433557 3.462737e-01 0.461 0 0
EPHB-mediated forward signaling R-HSA-3928662 3.517083e-01 0.454 0 0
DAP12 interactions R-HSA-2172127 3.517083e-01 0.454 0 0
RMTs methylate histone arginines R-HSA-3214858 3.517083e-01 0.454 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 3.521399e-01 0.453 0 0
Intracellular signaling by second messengers R-HSA-9006925 3.555588e-01 0.449 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 3.570982e-01 0.447 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 3.570982e-01 0.447 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 3.570982e-01 0.447 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 3.570982e-01 0.447 0 0
Nucleosome assembly R-HSA-774815 3.570982e-01 0.447 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 3.570982e-01 0.447 0 0
DAG and IP3 signaling R-HSA-1489509 3.570982e-01 0.447 0 0
Signaling by FGFR3 R-HSA-5654741 3.570982e-01 0.447 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 3.624435e-01 0.441 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 3.624435e-01 0.441 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 3.624435e-01 0.441 0 0
Signaling downstream of RAS mutants R-HSA-9649948 3.624435e-01 0.441 0 0
Signaling by RAS mutants R-HSA-6802949 3.624435e-01 0.441 0 0
Diseases of DNA repair R-HSA-9675135 3.624435e-01 0.441 0 0
Regulation of pyruvate metabolism R-HSA-9861718 3.624435e-01 0.441 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 3.624435e-01 0.441 0 0
Estrogen-dependent gene expression R-HSA-9018519 3.641092e-01 0.439 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 3.670889e-01 0.435 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 3.677447e-01 0.434 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 3.677447e-01 0.434 0 0
GPER1 signaling R-HSA-9634597 3.730022e-01 0.428 0 0
Gap junction trafficking and regulation R-HSA-157858 3.782163e-01 0.422 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 3.782163e-01 0.422 0 0
Immune System R-HSA-168256 3.783942e-01 0.422 1 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 3.789533e-01 0.421 0 0
Signaling by FGFR2 in disease R-HSA-5655253 3.833874e-01 0.416 0 0
Late Phase of HIV Life Cycle R-HSA-162599 3.848514e-01 0.415 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 3.885157e-01 0.411 0 0
Branched-chain amino acid catabolism R-HSA-70895 3.885157e-01 0.411 0 0
Meiotic recombination R-HSA-912446 3.885157e-01 0.411 0 0
The phototransduction cascade R-HSA-2514856 3.885157e-01 0.411 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 3.936018e-01 0.405 0 0
Orc1 removal from chromatin R-HSA-68949 3.936018e-01 0.405 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 3.936018e-01 0.405 0 0
Adaptive Immune System R-HSA-1280218 3.960413e-01 0.402 0 0
Meiotic synapsis R-HSA-1221632 3.986458e-01 0.399 0 0
Visual phototransduction R-HSA-2187338 3.994904e-01 0.398 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 4.023991e-01 0.395 1 0
S Phase R-HSA-69242 4.023991e-01 0.395 0 0
Translation initiation complex formation R-HSA-72649 4.036482e-01 0.394 0 0
MITF-M-dependent gene expression R-HSA-9856651 4.081969e-01 0.389 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 4.135294e-01 0.383 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 4.135294e-01 0.383 0 0
Signaling by EGFR R-HSA-177929 4.135294e-01 0.383 0 0
Signaling by FGFR1 R-HSA-5654736 4.135294e-01 0.383 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 4.135294e-01 0.383 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 4.184089e-01 0.378 0 0
Dual incision in TC-NER R-HSA-6782135 4.232481e-01 0.373 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 4.232481e-01 0.373 0 0
Triglyceride metabolism R-HSA-8979227 4.280473e-01 0.369 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 4.280473e-01 0.369 0 0
Amino acid transport across the plasma membrane R-HSA-352230 4.280473e-01 0.369 0 0
HIV Life Cycle R-HSA-162587 4.282723e-01 0.368 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 4.328069e-01 0.364 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 4.328069e-01 0.364 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 4.328069e-01 0.364 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 4.328069e-01 0.364 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 4.328069e-01 0.364 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 4.328069e-01 0.364 0 0
Interferon Signaling R-HSA-913531 4.342910e-01 0.362 1 0
Viral Messenger RNA Synthesis R-HSA-168325 4.375271e-01 0.359 0 0
PLC beta mediated events R-HSA-112043 4.375271e-01 0.359 0 0
Aquaporin-mediated transport R-HSA-445717 4.375271e-01 0.359 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 4.375271e-01 0.359 0 0
Signaling by PDGF R-HSA-186797 4.422084e-01 0.354 0 0
Platelet activation, signaling and aggregation R-HSA-76002 4.434562e-01 0.353 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 4.468510e-01 0.350 0 0
Signaling by PTK6 R-HSA-8848021 4.468510e-01 0.350 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 4.560215e-01 0.341 0 0
Parasitic Infection Pathways R-HSA-9824443 4.586240e-01 0.339 0 0
Leishmania infection R-HSA-9658195 4.586240e-01 0.339 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 4.618227e-01 0.336 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 4.650410e-01 0.333 0 0
G-protein mediated events R-HSA-112040 4.650410e-01 0.333 0 0
SLC-mediated transport of amino acids R-HSA-9958863 4.650410e-01 0.333 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 4.700546e-01 0.328 0 0
Developmental Biology R-HSA-1266738 4.737135e-01 0.324 1 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 4.754893e-01 0.323 0 0
Leishmania parasite growth and survival R-HSA-9664433 4.754893e-01 0.323 0 0
Ub-specific processing proteases R-HSA-5689880 4.754893e-01 0.323 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 4.781942e-01 0.320 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 4.782928e-01 0.320 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 4.782928e-01 0.320 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 4.782928e-01 0.320 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 4.782928e-01 0.320 0 0
SARS-CoV-1 Infection R-HSA-9678108 4.808906e-01 0.318 0 0
Retinoid metabolism and transport R-HSA-975634 4.826372e-01 0.316 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 4.826372e-01 0.316 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 4.869457e-01 0.313 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 4.869457e-01 0.313 0 0
PIP3 activates AKT signaling R-HSA-1257604 4.884247e-01 0.311 0 0
Switching of origins to a post-replicative state R-HSA-69052 4.912186e-01 0.309 0 0
G2/M DNA damage checkpoint R-HSA-69473 4.954562e-01 0.305 0 0
Signaling by ERBB4 R-HSA-1236394 4.954562e-01 0.305 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 4.996587e-01 0.301 0 0
ISG15 antiviral mechanism R-HSA-1169408 4.996587e-01 0.301 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 5.038265e-01 0.298 0 0
UCH proteinases R-HSA-5689603 5.038265e-01 0.298 0 0
Signaling by NOTCH1 R-HSA-1980143 5.038265e-01 0.298 0 0
Hemostasis R-HSA-109582 5.072827e-01 0.295 0 0
RNA Polymerase I Transcription R-HSA-73864 5.120590e-01 0.291 0 0
Nuclear Receptor transcription pathway R-HSA-383280 5.120590e-01 0.291 0 0
Integrin cell surface interactions R-HSA-216083 5.120590e-01 0.291 0 0
Disease R-HSA-1643685 5.127390e-01 0.290 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 5.201560e-01 0.284 0 0
Toll-like Receptor Cascades R-HSA-168898 5.228549e-01 0.282 1 0
Processing of DNA double-strand break ends R-HSA-5693607 5.241543e-01 0.281 0 0
Amyloid fiber formation R-HSA-977225 5.241543e-01 0.281 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 5.241543e-01 0.281 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 5.241543e-01 0.281 0 0
Cytoprotection by HMOX1 R-HSA-9707564 5.320519e-01 0.274 0 0
HCMV Early Events R-HSA-9609690 5.355001e-01 0.271 0 0
Oncogenic MAPK signaling R-HSA-6802957 5.398195e-01 0.268 0 0
Meiosis R-HSA-1500620 5.398195e-01 0.268 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 5.398195e-01 0.268 0 0
Transmission across Chemical Synapses R-HSA-112315 5.455359e-01 0.263 0 0
Pyruvate metabolism R-HSA-70268 5.512315e-01 0.259 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 5.528181e-01 0.257 0 0
Diseases of programmed cell death R-HSA-9645723 5.549727e-01 0.256 0 0
ER-Phagosome pathway R-HSA-1236974 5.586830e-01 0.253 0 0
Extracellular matrix organization R-HSA-1474244 5.611727e-01 0.251 0 0
Downstream TCR signaling R-HSA-202424 5.623626e-01 0.250 0 0
Neurotransmitter release cycle R-HSA-112310 5.623626e-01 0.250 0 0
Cytokine Signaling in Immune system R-HSA-1280215 5.641244e-01 0.249 1 0
Transcriptional Regulation by MECP2 R-HSA-8986944 5.660117e-01 0.247 0 0
EPH-Ephrin signaling R-HSA-2682334 5.732195e-01 0.242 0 0
Innate Immune System R-HSA-168249 5.740706e-01 0.241 1 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 5.767671e-01 0.239 0 0
FCGR activation R-HSA-2029481 5.767788e-01 0.239 0 0
Assembly of the pre-replicative complex R-HSA-68867 5.767788e-01 0.239 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 5.791105e-01 0.237 0 0
Collagen formation R-HSA-1474290 5.803086e-01 0.236 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 5.838091e-01 0.234 0 0
COPI-mediated anterograde transport R-HSA-6807878 5.907236e-01 0.229 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 5.907236e-01 0.229 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 5.907236e-01 0.229 0 0
MAPK family signaling cascades R-HSA-5683057 5.914652e-01 0.228 0 0
Post-translational protein phosphorylation R-HSA-8957275 5.975240e-01 0.224 0 0
Regulation of insulin secretion R-HSA-422356 5.975240e-01 0.224 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 5.975240e-01 0.224 1 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 5.975240e-01 0.224 1 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 5.975240e-01 0.224 1 0
p75 NTR receptor-mediated signalling R-HSA-193704 6.008820e-01 0.221 0 0
Hedgehog 'off' state R-HSA-5610787 6.042122e-01 0.219 0 0
Glycolysis R-HSA-70171 6.042122e-01 0.219 0 0
Interleukin-1 signaling R-HSA-9020702 6.075148e-01 0.216 1 1
Regulation of endogenous retroelements R-HSA-9842860 6.107901e-01 0.214 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 6.107901e-01 0.214 1 1
HIV Infection R-HSA-162906 6.109265e-01 0.214 0 0
SARS-CoV-2-host interactions R-HSA-9705683 6.131283e-01 0.212 0 0
Opioid Signalling R-HSA-111885 6.172595e-01 0.210 0 0
Signaling by Nuclear Receptors R-HSA-9006931 6.203970e-01 0.207 0 0
Nucleotide Excision Repair R-HSA-5696398 6.236221e-01 0.205 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 6.236221e-01 0.205 1 0
Signaling by Interleukins R-HSA-449147 6.273238e-01 0.203 1 0
Synthesis of DNA R-HSA-69239 6.298798e-01 0.201 0 0
Gene Silencing by RNA R-HSA-211000 6.298798e-01 0.201 0 0
Metabolism of nucleotides R-HSA-15869 6.304033e-01 0.200 0 0
ESR-mediated signaling R-HSA-8939211 6.325204e-01 0.199 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 6.329697e-01 0.199 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 6.329697e-01 0.199 0 0
Antigen processing-Cross presentation R-HSA-1236975 6.329697e-01 0.199 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 6.329697e-01 0.199 1 0
DNA Replication Pre-Initiation R-HSA-69002 6.360341e-01 0.197 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 6.360341e-01 0.197 1 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 6.390731e-01 0.194 1 0
MyD88-independent TLR4 cascade R-HSA-166166 6.390731e-01 0.194 1 0
FCERI mediated MAPK activation R-HSA-2871796 6.450757e-01 0.190 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 6.480398e-01 0.188 1 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 6.509792e-01 0.186 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 6.538943e-01 0.184 0 0
M Phase R-HSA-68886 6.545842e-01 0.184 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 6.562351e-01 0.183 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 6.567853e-01 0.183 1 0
HCMV Infection R-HSA-9609646 6.591928e-01 0.181 0 0
Interferon alpha/beta signaling R-HSA-909733 6.596523e-01 0.181 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 6.596523e-01 0.181 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 6.596523e-01 0.181 0 0
Eukaryotic Translation Initiation R-HSA-72613 6.624955e-01 0.179 0 0
Cap-dependent Translation Initiation R-HSA-72737 6.624955e-01 0.179 0 0
Mitochondrial biogenesis R-HSA-1592230 6.653151e-01 0.177 0 0
Glucose metabolism R-HSA-70326 6.653151e-01 0.177 0 0
Homology Directed Repair R-HSA-5693538 6.681113e-01 0.175 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 6.708844e-01 0.173 0 0
Cell Cycle Checkpoints R-HSA-69620 6.748298e-01 0.171 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 6.763617e-01 0.170 0 0
SLC-mediated transmembrane transport R-HSA-425407 6.787598e-01 0.168 0 0
G1/S Transition R-HSA-69206 6.896623e-01 0.161 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 6.896623e-01 0.161 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 6.896623e-01 0.161 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 6.896623e-01 0.161 0 0
Cellular response to chemical stress R-HSA-9711123 6.935585e-01 0.159 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 6.973807e-01 0.157 0 0
Reproduction R-HSA-1474165 7.049086e-01 0.152 0 0
Adipogenesis R-HSA-9843745 7.073763e-01 0.150 0 0
Circadian clock R-HSA-9909396 7.098236e-01 0.149 0 0
Degradation of the extracellular matrix R-HSA-1474228 7.098236e-01 0.149 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 7.182868e-01 0.144 0 0
Integration of energy metabolism R-HSA-163685 7.217585e-01 0.142 0 0
Cell Cycle, Mitotic R-HSA-69278 7.235476e-01 0.141 0 0
Signaling by Hedgehog R-HSA-5358351 7.263949e-01 0.139 0 0
RAF/MAP kinase cascade R-HSA-5673001 7.300151e-01 0.137 0 0
Leishmania phagocytosis R-HSA-9664417 7.309546e-01 0.136 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 7.309546e-01 0.136 0 0
Parasite infection R-HSA-9664407 7.309546e-01 0.136 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 7.376531e-01 0.132 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 7.413303e-01 0.130 0 0
FCERI mediated NF-kB activation R-HSA-2871837 7.420265e-01 0.130 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 7.463276e-01 0.127 0 0
ER to Golgi Anterograde Transport R-HSA-199977 7.484514e-01 0.126 0 0
Signaling by NTRKs R-HSA-166520 7.505575e-01 0.125 0 0
Gastrulation R-HSA-9758941 7.526461e-01 0.123 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 7.567714e-01 0.121 0 0
Interleukin-1 family signaling R-HSA-446652 7.588083e-01 0.120 1 0
DNA Replication R-HSA-69306 7.608284e-01 0.119 0 0
Protein localization R-HSA-9609507 7.608284e-01 0.119 0 0
Death Receptor Signaling R-HSA-73887 7.628316e-01 0.118 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 7.648182e-01 0.116 0 0
PPARA activates gene expression R-HSA-1989781 7.648182e-01 0.116 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 7.687420e-01 0.114 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 7.706794e-01 0.113 0 0
Neuronal System R-HSA-112316 7.763601e-01 0.110 0 0
Organelle biogenesis and maintenance R-HSA-1852241 7.771136e-01 0.110 0 0
Separation of Sister Chromatids R-HSA-2467813 7.819703e-01 0.107 0 0
SLC transporter disorders R-HSA-5619102 7.874071e-01 0.104 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 7.944473e-01 0.100 0 0
G alpha (s) signalling events R-HSA-418555 7.961709e-01 0.099 0 0
Influenza Infection R-HSA-168255 8.094531e-01 0.092 0 0
Cellular Senescence R-HSA-2559583 8.110517e-01 0.091 1 0
SARS-CoV-2 Infection R-HSA-9694516 8.145570e-01 0.089 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 8.233709e-01 0.084 0 0
Cilium Assembly R-HSA-5617833 8.263240e-01 0.083 0 0
Mitotic Prometaphase R-HSA-68877 8.306621e-01 0.081 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 8.430413e-01 0.074 0 0
Signaling by ROBO receptors R-HSA-376176 8.443601e-01 0.073 0 0
Bacterial Infection Pathways R-HSA-9824439 8.588996e-01 0.066 0 0
Neddylation R-HSA-8951664 8.674272e-01 0.062 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 8.760929e-01 0.057 0 0
rRNA processing R-HSA-72312 8.791955e-01 0.056 0 0
Signaling by NOTCH R-HSA-157118 8.870973e-01 0.052 0 0
Disorders of transmembrane transporters R-HSA-5619115 8.935892e-01 0.049 0 0
Transport of small molecules R-HSA-382551 9.247067e-01 0.034 0 0
Cellular responses to stimuli R-HSA-8953897 9.283194e-01 0.032 1 0
Post-translational protein modification R-HSA-597592 9.469527e-01 0.024 0 0
Axon guidance R-HSA-422475 9.513393e-01 0.022 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.520799e-01 0.021 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.606062e-01 0.017 0 0
Nervous system development R-HSA-9675108 9.626543e-01 0.017 0 0
G alpha (i) signalling events R-HSA-418594 9.729416e-01 0.012 0 0
Cellular responses to stress R-HSA-2262752 9.761853e-01 0.010 1 0
Asparagine N-linked glycosylation R-HSA-446203 9.761995e-01 0.010 0 0
Diseases of metabolism R-HSA-5668914 9.771965e-01 0.010 0 0
Translation R-HSA-72766 9.775836e-01 0.010 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.820600e-01 0.008 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.955983e-01 0.002 0 0
Metabolism of proteins R-HSA-392499 9.975013e-01 0.001 0 0
GPCR downstream signalling R-HSA-388396 9.988687e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.994540e-01 0.000 0 0
Sensory Perception R-HSA-9709957 9.997719e-01 0.000 0 0
Metabolism of lipids R-HSA-556833 9.999721e-01 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 0.000 0 0
NOD1/2 Signaling Pathway R-HSA-168638 1.000000e+00 0.000 1 1
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 1.000000e+00 0.000 1 0
Interleukin-17 signaling R-HSA-448424 1.000000e+00 0.000 1 0
MAP kinase activation R-HSA-450294 1.000000e+00 0.000 1 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 1.000000e+00 0.000 1 1
Myogenesis R-HSA-525793 1.000000e+00 0.000 1 1
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.000000e+00 0.000 1 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 1.000000e+00 0.000 1 1
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.110223e-16 15.955 0 0
Cell Cycle, Mitotic R-HSA-69278 1.221245e-15 14.913 0 0
Cell Cycle R-HSA-1640170 2.287059e-14 13.641 0 0
Axon guidance R-HSA-422475 5.484502e-14 13.261 0 0
Nervous system development R-HSA-9675108 3.117506e-13 12.506 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.109446e-12 11.955 0 0
M Phase R-HSA-68886 6.251444e-12 11.204 0 0
Cell Cycle Checkpoints R-HSA-69620 2.629266e-09 8.580 0 0
Cellular responses to stress R-HSA-2262752 3.765223e-09 8.424 1 0
Cellular responses to stimuli R-HSA-8953897 5.150604e-09 8.288 1 0
mRNA Splicing - Major Pathway R-HSA-72163 7.391992e-09 8.131 0 0
Signaling by ALK in cancer R-HSA-9700206 1.138978e-08 7.943 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.138978e-08 7.943 0 0
Metabolism of RNA R-HSA-8953854 1.232023e-08 7.909 0 0
Cellular response to heat stress R-HSA-3371556 4.310485e-08 7.365 0 0
mRNA Splicing R-HSA-72172 5.649630e-08 7.248 0 0
G2/M Checkpoints R-HSA-69481 9.261539e-08 7.033 0 0
Mitotic Anaphase R-HSA-68882 1.123209e-07 6.950 0 0
Signal Transduction R-HSA-162582 1.187443e-07 6.925 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.326211e-07 6.877 0 0
Recycling pathway of L1 R-HSA-437239 1.670574e-07 6.777 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.243012e-07 6.649 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.394032e-07 6.621 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 3.441451e-07 6.463 0 0
Intracellular signaling by second messengers R-HSA-9006925 4.044119e-07 6.393 0 0
Cell-Cell communication R-HSA-1500931 3.936705e-07 6.405 0 0
L1CAM interactions R-HSA-373760 3.926600e-07 6.406 0 0
Mitotic Prometaphase R-HSA-68877 4.409001e-07 6.356 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 4.925764e-07 6.308 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 4.925764e-07 6.308 0 0
HSF1-dependent transactivation R-HSA-3371571 6.969921e-07 6.157 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 7.523103e-07 6.124 0 0
Membrane Trafficking R-HSA-199991 7.217878e-07 6.142 0 0
Attenuation phase R-HSA-3371568 8.304264e-07 6.081 0 0
Mitotic Prophase R-HSA-68875 9.286230e-07 6.032 0 0
mRNA 3'-end processing R-HSA-72187 9.742708e-07 6.011 0 0
Signaling by ROBO receptors R-HSA-376176 1.156698e-06 5.937 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.445116e-06 5.840 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.679189e-06 5.775 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.201699e-06 5.657 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 2.754049e-06 5.560 0 0
RAF/MAP kinase cascade R-HSA-5673001 3.068031e-06 5.513 0 0
Apoptotic execution phase R-HSA-75153 3.297705e-06 5.482 0 0
MAPK family signaling cascades R-HSA-5683057 3.541137e-06 5.451 0 0
Separation of Sister Chromatids R-HSA-2467813 4.762125e-06 5.322 0 0
Mitotic G2-G2/M phases R-HSA-453274 5.135799e-06 5.289 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 6.753280e-06 5.170 1 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 7.215240e-06 5.142 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 7.751213e-06 5.111 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.096079e-05 4.960 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.298338e-05 4.887 0 0
G2/M Transition R-HSA-69275 1.311056e-05 4.882 0 0
HSF1 activation R-HSA-3371511 1.811340e-05 4.742 0 0
Cellular Senescence R-HSA-2559583 1.844205e-05 4.734 1 0
Cell junction organization R-HSA-446728 1.918472e-05 4.717 0 0
G2/M DNA damage checkpoint R-HSA-69473 2.475682e-05 4.606 0 0
DNA Replication Pre-Initiation R-HSA-69002 3.079832e-05 4.511 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 4.096198e-05 4.388 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 4.096198e-05 4.388 0 0
Assembly of the pre-replicative complex R-HSA-68867 4.022696e-05 4.395 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 4.370759e-05 4.359 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 4.511185e-05 4.346 0 0
G1/S Transition R-HSA-69206 5.274875e-05 4.278 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 5.351983e-05 4.271 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 5.613653e-05 4.251 0 0
Nuclear Receptor transcription pathway R-HSA-383280 6.063529e-05 4.217 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 6.292757e-05 4.201 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 6.329550e-05 4.199 0 0
Chromatin organization R-HSA-4839726 6.537357e-05 4.185 0 0
Regulation of CDH1 Function R-HSA-9764561 7.741905e-05 4.111 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 7.860324e-05 4.105 0 0
Apoptosis R-HSA-109581 8.093857e-05 4.092 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 8.374802e-05 4.077 0 0
Post NMDA receptor activation events R-HSA-438064 9.877251e-05 4.005 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.002106e-04 3.999 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 1.171732e-04 3.931 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 1.211068e-04 3.917 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.331514e-04 3.876 0 0
Developmental Biology R-HSA-1266738 1.349449e-04 3.870 1 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.496040e-04 3.825 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.583029e-04 3.801 0 0
Signaling by ERBB2 R-HSA-1227986 1.583029e-04 3.801 0 0
Kinesins R-HSA-983189 1.583029e-04 3.801 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.771793e-04 3.752 0 0
Aggrephagy R-HSA-9646399 1.771793e-04 3.752 0 0
Programmed Cell Death R-HSA-5357801 1.811433e-04 3.742 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.833295e-04 3.737 0 0
Signaling by VEGF R-HSA-194138 1.928032e-04 3.715 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 2.091206e-04 3.680 0 0
PKR-mediated signaling R-HSA-9833482 1.995144e-04 3.700 1 1
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 2.091206e-04 3.680 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 2.253253e-04 3.647 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.329589e-04 3.633 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.382208e-04 3.623 0 0
Nuclear import of Rev protein R-HSA-180746 2.253253e-04 3.647 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 2.775632e-04 3.557 0 0
EPH-Ephrin signaling R-HSA-2682334 2.993526e-04 3.524 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 3.234156e-04 3.490 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 3.253507e-04 3.488 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 3.402534e-04 3.468 0 0
Cell-cell junction organization R-HSA-421270 3.456479e-04 3.461 0 0
S Phase R-HSA-69242 3.857279e-04 3.414 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 3.951889e-04 3.403 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 4.358585e-04 3.361 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 4.369780e-04 3.360 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 4.553350e-04 3.342 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 4.657020e-04 3.332 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 4.853498e-04 3.314 1 1
Adherens junctions interactions R-HSA-418990 4.729693e-04 3.325 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 4.565948e-04 3.340 0 0
Host Interactions of HIV factors R-HSA-162909 4.898670e-04 3.310 0 0
Ribosome-associated quality control R-HSA-9948299 4.920636e-04 3.308 0 0
Oncogenic MAPK signaling R-HSA-6802957 5.043558e-04 3.297 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 5.689674e-04 3.245 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 5.762624e-04 3.239 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 6.802739e-04 3.167 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 6.530819e-04 3.185 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 6.833965e-04 3.165 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 6.427564e-04 3.192 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 6.964286e-04 3.157 0 0
DNA Replication R-HSA-69306 7.271595e-04 3.138 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 7.513240e-04 3.124 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 7.891373e-04 3.103 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 8.008209e-04 3.096 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 8.468265e-04 3.072 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 8.197378e-04 3.086 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 8.468265e-04 3.072 0 0
Signalling to ERKs R-HSA-187687 7.891373e-04 3.103 0 0
Deubiquitination R-HSA-5688426 8.000293e-04 3.097 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 8.485687e-04 3.071 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 9.183528e-04 3.037 0 0
Nuclear Envelope Breakdown R-HSA-2980766 9.499980e-04 3.022 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.038042e-03 2.984 0 0
RET signaling R-HSA-8853659 1.023064e-03 2.990 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.014661e-03 2.994 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 9.767657e-04 3.010 0 0
Regulation of TP53 Activity R-HSA-5633007 9.946356e-04 3.002 1 0
Switching of origins to a post-replicative state R-HSA-69052 1.014661e-03 2.994 0 0
Chromatin modifying enzymes R-HSA-3247509 9.583241e-04 3.018 0 0
Signaling by NTRKs R-HSA-166520 1.143591e-03 2.942 0 0
Ephrin signaling R-HSA-3928664 1.145081e-03 2.941 0 0
Signaling by FGFR in disease R-HSA-1226099 1.210689e-03 2.917 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 1.329324e-03 2.876 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.367499e-03 2.864 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.367499e-03 2.864 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.313684e-03 2.882 0 0
HDACs deacetylate histones R-HSA-3214815 1.379666e-03 2.860 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.431143e-03 2.844 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.431143e-03 2.844 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 1.378722e-03 2.861 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.333111e-03 2.875 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.333111e-03 2.875 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.431143e-03 2.844 0 0
Signaling by PTK6 R-HSA-8848021 1.431143e-03 2.844 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 1.329324e-03 2.876 0 0
Centrosome maturation R-HSA-380287 1.438717e-03 2.842 0 0
RAF activation R-HSA-5673000 1.531863e-03 2.815 0 0
Signaling by EGFR R-HSA-177929 1.679631e-03 2.775 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.688982e-03 2.772 0 0
ALK mutants bind TKIs R-HSA-9700645 1.690514e-03 2.772 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.722872e-03 2.764 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.749340e-03 2.757 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.783084e-03 2.749 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.786710e-03 2.748 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.822444e-03 2.739 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.822444e-03 2.739 0 0
Meiotic synapsis R-HSA-1221632 2.000078e-03 2.699 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.960343e-03 2.708 0 0
Gap junction trafficking and regulation R-HSA-157858 1.949126e-03 2.710 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.022873e-03 2.694 0 0
DNA methylation R-HSA-5334118 2.062551e-03 2.686 0 0
Formation of a pool of free 40S subunits R-HSA-72689 2.080085e-03 2.682 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 2.080085e-03 2.682 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 2.226350e-03 2.652 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.294144e-03 2.639 0 0
Myogenesis R-HSA-525793 2.377064e-03 2.624 1 1
MITF-M-dependent gene expression R-HSA-9856651 2.394607e-03 2.621 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.398353e-03 2.620 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 2.470816e-03 2.607 0 0
PRC2 methylates histones and DNA R-HSA-212300 2.485039e-03 2.605 0 0
AURKA Activation by TPX2 R-HSA-8854518 2.448193e-03 2.611 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 2.463559e-03 2.608 0 0
Cell-extracellular matrix interactions R-HSA-446353 2.679908e-03 2.572 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 2.485039e-03 2.605 0 0
Gene expression (Transcription) R-HSA-74160 2.427640e-03 2.615 1 0
Activation of BH3-only proteins R-HSA-114452 2.677443e-03 2.572 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 2.679908e-03 2.572 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 2.637168e-03 2.579 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 2.537355e-03 2.596 0 0
HIV Infection R-HSA-162906 2.769847e-03 2.558 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.788008e-03 2.555 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.788008e-03 2.555 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.788008e-03 2.555 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.788008e-03 2.555 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.788008e-03 2.555 0 0
DNA Double Strand Break Response R-HSA-5693606 2.901508e-03 2.537 0 0
Striated Muscle Contraction R-HSA-390522 2.924918e-03 2.534 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 2.924918e-03 2.534 0 0
Metabolism of non-coding RNA R-HSA-194441 2.934342e-03 2.532 0 0
snRNP Assembly R-HSA-191859 2.934342e-03 2.532 0 0
Clathrin-mediated endocytosis R-HSA-8856828 2.962705e-03 2.528 0 0
SARS-CoV-2-host interactions R-HSA-9705683 3.025762e-03 2.519 0 0
Packaging Of Telomere Ends R-HSA-171306 3.113756e-03 2.507 0 0
Orc1 removal from chromatin R-HSA-68949 3.494441e-03 2.457 0 0
TCR signaling R-HSA-202403 3.193188e-03 2.496 0 0
EPHB-mediated forward signaling R-HSA-3928662 3.381424e-03 2.471 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 3.453804e-03 2.462 0 0
Gap junction trafficking R-HSA-190828 3.381424e-03 2.471 0 0
Cytokine Signaling in Immune system R-HSA-1280215 3.252206e-03 2.488 1 0
RNA Polymerase I Promoter Opening R-HSA-73728 3.113756e-03 2.507 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 3.133908e-03 2.504 0 0
Influenza Infection R-HSA-168255 3.241511e-03 2.489 0 0
NRAGE signals death through JNK R-HSA-193648 3.507859e-03 2.455 0 0
HATs acetylate histones R-HSA-3214847 3.615769e-03 2.442 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 3.692722e-03 2.433 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 3.692722e-03 2.433 0 0
Synthesis of DNA R-HSA-69239 3.785968e-03 2.422 0 0
Prolonged ERK activation events R-HSA-169893 3.826355e-03 2.417 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 4.119071e-03 2.385 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 4.119071e-03 2.385 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 4.123994e-03 2.385 0 0
Nucleosome assembly R-HSA-774815 4.123994e-03 2.385 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 4.146502e-03 2.382 0 0
Degradation of CDH1 R-HSA-9766229 4.177334e-03 2.379 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 4.195936e-03 2.377 0 0
Signaling by APC mutants R-HSA-4839744 4.265865e-03 2.370 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 4.265865e-03 2.370 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 4.265865e-03 2.370 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 4.265865e-03 2.370 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 4.291920e-03 2.367 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 4.363216e-03 2.360 0 0
Regulation of signaling by CBL R-HSA-912631 4.729612e-03 2.325 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 4.996542e-03 2.301 0 0
Signaling downstream of RAS mutants R-HSA-9649948 4.996542e-03 2.301 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 4.996542e-03 2.301 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 4.708442e-03 2.327 0 0
Signaling by RAS mutants R-HSA-6802949 4.996542e-03 2.301 0 0
Long-term potentiation R-HSA-9620244 4.705509e-03 2.327 0 0
TCF dependent signaling in response to WNT R-HSA-201681 4.751635e-03 2.323 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 4.705509e-03 2.327 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 4.705509e-03 2.327 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 4.900673e-03 2.310 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 4.803408e-03 2.318 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 5.147986e-03 2.288 0 0
Vesicle-mediated transport R-HSA-5653656 5.150794e-03 2.288 0 0
ISG15 antiviral mechanism R-HSA-1169408 5.332578e-03 2.273 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 5.488240e-03 2.261 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 5.760512e-03 2.240 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 5.887414e-03 2.230 0 0
Regulation of KIT signaling R-HSA-1433559 5.900981e-03 2.229 0 0
Signaling by SCF-KIT R-HSA-1433557 5.980111e-03 2.223 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 6.061970e-03 2.217 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 6.193150e-03 2.208 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 6.193150e-03 2.208 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 6.193150e-03 2.208 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 6.193150e-03 2.208 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 6.193150e-03 2.208 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 6.193150e-03 2.208 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 6.193150e-03 2.208 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 6.193150e-03 2.208 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 6.193150e-03 2.208 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 6.193150e-03 2.208 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 6.193150e-03 2.208 0 0
Activation of RAC1 R-HSA-428540 6.356316e-03 2.197 0 0
Co-inhibition by CTLA4 R-HSA-389513 6.330739e-03 2.199 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 7.118940e-03 2.148 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 6.506860e-03 2.187 0 0
Activation of the pre-replicative complex R-HSA-68962 6.506860e-03 2.187 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 7.039218e-03 2.152 0 0
Regulation of PTEN gene transcription R-HSA-8943724 6.899752e-03 2.161 0 0
Peptide chain elongation R-HSA-156902 6.331744e-03 2.198 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 6.372393e-03 2.196 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 6.510348e-03 2.186 1 0
Nef and signal transduction R-HSA-164944 6.195019e-03 2.208 0 0
Eukaryotic Translation Elongation R-HSA-156842 6.911289e-03 2.160 0 0
Selective autophagy R-HSA-9663891 6.331744e-03 2.198 0 0
Signaling by AXIN mutants R-HSA-4839735 6.356316e-03 2.197 0 0
Ub-specific processing proteases R-HSA-5689880 6.793373e-03 2.168 0 0
FLT3 Signaling R-HSA-9607240 7.162104e-03 2.145 0 0
Co-stimulation by CD28 R-HSA-389356 7.197859e-03 2.143 0 0
G1 Phase R-HSA-69236 7.210524e-03 2.142 0 0
Cyclin D associated events in G1 R-HSA-69231 7.210524e-03 2.142 0 0
Uptake and function of anthrax toxins R-HSA-5210891 7.260436e-03 2.139 0 0
Signaling by Hippo R-HSA-2028269 7.260436e-03 2.139 0 0
Interferon Signaling R-HSA-913531 7.317055e-03 2.136 1 0
COPI-mediated anterograde transport R-HSA-6807878 7.485617e-03 2.126 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 7.536556e-03 2.123 0 0
Amplification of signal from the kinetochores R-HSA-141424 7.536556e-03 2.123 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 7.855438e-03 2.105 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 8.137471e-03 2.090 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 8.173952e-03 2.088 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 8.211823e-03 2.086 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 8.225056e-03 2.085 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 8.225056e-03 2.085 0 0
Eukaryotic Translation Initiation R-HSA-72613 8.231821e-03 2.085 0 0
Cap-dependent Translation Initiation R-HSA-72737 8.231821e-03 2.085 0 0
DNA Double-Strand Break Repair R-HSA-5693532 8.265801e-03 2.083 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 8.457816e-03 2.073 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 8.562234e-03 2.067 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 8.562234e-03 2.067 0 0
Regulation of endogenous retroelements R-HSA-9842860 9.061391e-03 2.043 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 9.081998e-03 2.042 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 9.129446e-03 2.040 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 9.163480e-03 2.038 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 9.311665e-03 2.031 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 9.691056e-03 2.014 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.758653e-03 2.011 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 9.856606e-03 2.006 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 9.856606e-03 2.006 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 9.856606e-03 2.006 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.002132e-02 1.999 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.005600e-02 1.998 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.007696e-02 1.997 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.028391e-02 1.988 0 0
Integrin signaling R-HSA-354192 1.236061e-02 1.908 0 0
Generation of second messenger molecules R-HSA-202433 1.247812e-02 1.904 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 1.247812e-02 1.904 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.217042e-02 1.915 0 0
Protein folding R-HSA-391251 1.187392e-02 1.925 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.185684e-02 1.926 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.236061e-02 1.908 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.201640e-02 1.920 0 0
MHC class II antigen presentation R-HSA-2132295 1.071951e-02 1.970 0 0
RNA Polymerase II Transcription R-HSA-73857 1.048026e-02 1.980 1 0
Defective pyroptosis R-HSA-9710421 1.236488e-02 1.908 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 1.161075e-02 1.935 0 0
Interleukin-2 family signaling R-HSA-451927 1.247812e-02 1.904 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 1.236061e-02 1.908 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 1.134053e-02 1.945 0 0
Gene Silencing by RNA R-HSA-211000 1.079718e-02 1.967 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.275406e-02 1.894 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.331440e-02 1.876 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.356858e-02 1.867 0 0
PECAM1 interactions R-HSA-210990 1.425311e-02 1.846 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.445045e-02 1.840 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 1.464151e-02 1.834 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.485261e-02 1.828 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.485261e-02 1.828 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 1.488457e-02 1.827 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.488457e-02 1.827 0 0
Cleavage of the damaged purine R-HSA-110331 1.502378e-02 1.823 0 0
Formation of annular gap junctions R-HSA-196025 1.537786e-02 1.813 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.547698e-02 1.810 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.547698e-02 1.810 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.588704e-02 1.799 0 0
Homology Directed Repair R-HSA-5693538 1.627669e-02 1.788 0 0
Formation of definitive endoderm R-HSA-9823730 1.635644e-02 1.786 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.635644e-02 1.786 0 0
Signaling by Interleukins R-HSA-449147 1.655744e-02 1.781 1 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.723234e-02 1.764 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.723234e-02 1.764 0 0
Signal regulatory protein family interactions R-HSA-391160 1.731160e-02 1.762 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.731160e-02 1.762 0 0
tRNA processing in the nucleus R-HSA-6784531 1.734918e-02 1.761 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.763626e-02 1.754 0 0
MAP2K and MAPK activation R-HSA-5674135 1.763626e-02 1.754 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.763626e-02 1.754 0 0
Depurination R-HSA-73927 1.794160e-02 1.746 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.808481e-02 1.743 0 0
Downstream signal transduction R-HSA-186763 1.810713e-02 1.742 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 1.810713e-02 1.742 0 0
Gap junction assembly R-HSA-190861 1.811351e-02 1.742 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 1.855945e-02 1.731 0 0
Diseases of programmed cell death R-HSA-9645723 1.870550e-02 1.728 0 0
Eukaryotic Translation Termination R-HSA-72764 1.870626e-02 1.728 0 0
Translation initiation complex formation R-HSA-72649 1.880462e-02 1.726 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 1.880462e-02 1.726 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.940405e-02 1.712 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.940405e-02 1.712 0 0
Regulation of RAS by GAPs R-HSA-5658442 1.950385e-02 1.710 0 0
Semaphorin interactions R-HSA-373755 1.986275e-02 1.702 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 2.016363e-02 1.695 0 0
HCMV Early Events R-HSA-9609690 2.070860e-02 1.684 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 2.076270e-02 1.683 0 0
Depyrimidination R-HSA-73928 2.076270e-02 1.683 0 0
Processing of DNA double-strand break ends R-HSA-5693607 2.084705e-02 1.681 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.377564e-02 1.624 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 2.377564e-02 1.624 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.238861e-02 1.650 0 0
Gap junction degradation R-HSA-190873 2.238861e-02 1.650 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 2.293502e-02 1.640 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.484605e-02 1.605 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.484605e-02 1.605 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.592939e-02 1.586 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 2.592939e-02 1.586 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.592939e-02 1.586 0 0
G1/S-Specific Transcription R-HSA-69205 2.570114e-02 1.590 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 2.505192e-02 1.601 0 0
G0 and Early G1 R-HSA-1538133 2.187252e-02 1.660 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 2.572848e-02 1.590 0 0
IGF1R signaling cascade R-HSA-2428924 2.264996e-02 1.645 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.238861e-02 1.650 0 0
Stabilization of p53 R-HSA-69541 2.127330e-02 1.672 0 0
Unwinding of DNA R-HSA-176974 2.238861e-02 1.650 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 2.592939e-02 1.586 0 0
Signaling by NOTCH4 R-HSA-9013694 2.612747e-02 1.583 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 2.293502e-02 1.640 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 2.600485e-02 1.585 0 0
Activation of ATR in response to replication stress R-HSA-176187 2.619194e-02 1.582 0 0
HIV Life Cycle R-HSA-162587 2.636432e-02 1.579 0 0
PTEN Regulation R-HSA-6807070 2.642372e-02 1.578 0 0
Signaling by Erythropoietin R-HSA-9006335 2.645844e-02 1.577 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 2.645844e-02 1.577 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.693789e-02 1.570 0 0
Signaling by LTK R-HSA-9842663 2.693789e-02 1.570 0 0
MAP kinase activation R-HSA-450294 2.706447e-02 1.568 1 0
Co-inhibition by PD-1 R-HSA-389948 2.756888e-02 1.560 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.833249e-02 1.548 0 0
PKMTs methylate histone lysines R-HSA-3214841 2.930971e-02 1.533 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 2.930971e-02 1.533 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 2.939778e-02 1.532 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.975827e-02 1.526 0 0
Smooth Muscle Contraction R-HSA-445355 2.984076e-02 1.525 0 0
SARS-CoV-2 Infection R-HSA-9694516 2.988150e-02 1.525 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 3.027596e-02 1.519 0 0
Degradation of DVL R-HSA-4641258 3.027596e-02 1.519 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 3.098801e-02 1.509 0 0
Hedgehog 'off' state R-HSA-5610787 3.124989e-02 1.505 0 0
Signal attenuation R-HSA-74749 3.128187e-02 1.505 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 3.173608e-02 1.498 0 0
Signaling by KIT in disease R-HSA-9669938 3.198377e-02 1.495 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 3.198377e-02 1.495 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 3.235686e-02 1.490 0 0
Somitogenesis R-HSA-9824272 3.268088e-02 1.486 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 3.268088e-02 1.486 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 3.268088e-02 1.486 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 3.429463e-02 1.465 0 0
Selenocysteine synthesis R-HSA-2408557 3.439126e-02 1.464 0 0
ESR-mediated signaling R-HSA-8939211 3.499883e-02 1.456 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 3.550585e-02 1.450 0 0
Frs2-mediated activation R-HSA-170968 3.550585e-02 1.450 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 3.553112e-02 1.449 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 3.553112e-02 1.449 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 3.602131e-02 1.443 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 3.602131e-02 1.443 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 3.665670e-02 1.436 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 3.665670e-02 1.436 0 0
IRS activation R-HSA-74713 3.841475e-02 1.416 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 3.841475e-02 1.416 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 4.969341e-02 1.304 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 4.969341e-02 1.304 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 4.969341e-02 1.304 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 4.220803e-02 1.375 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 4.570465e-02 1.340 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 4.748038e-02 1.323 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 4.748038e-02 1.323 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 4.748038e-02 1.323 0 0
Interleukin receptor SHC signaling R-HSA-912526 3.896764e-02 1.409 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 3.854226e-02 1.414 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 3.854226e-02 1.414 0 0
Interaction between L1 and Ankyrins R-HSA-445095 3.854226e-02 1.414 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 4.287754e-02 1.368 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 4.116079e-02 1.386 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 4.753320e-02 1.323 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 3.759273e-02 1.425 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 4.633156e-02 1.334 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 4.633156e-02 1.334 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 4.379620e-02 1.359 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 3.996759e-02 1.398 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 4.247570e-02 1.372 0 0
Estrogen-dependent gene expression R-HSA-9018519 4.461014e-02 1.351 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 4.699116e-02 1.328 0 0
ERK/MAPK targets R-HSA-198753 4.748038e-02 1.323 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 4.116079e-02 1.386 0 0
Nephrin family interactions R-HSA-373753 3.881457e-02 1.411 0 0
Signalling to RAS R-HSA-167044 4.748038e-02 1.323 0 0
Regulation of Apoptosis R-HSA-169911 4.287754e-02 1.368 0 0
RNA Polymerase I Transcription R-HSA-73864 4.078645e-02 1.389 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 4.587078e-02 1.338 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 4.570465e-02 1.340 0 0
Signaling by NOTCH R-HSA-157118 4.190188e-02 1.378 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 3.780187e-02 1.422 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 4.753320e-02 1.323 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 4.651389e-02 1.332 0 0
Base Excision Repair R-HSA-73884 3.757333e-02 1.425 0 0
Glycolysis R-HSA-70171 4.822752e-02 1.317 0 0
Viral Infection Pathways R-HSA-9824446 4.171876e-02 1.380 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 4.447624e-02 1.352 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 3.759273e-02 1.425 0 0
SARS-CoV-1-host interactions R-HSA-9692914 3.886132e-02 1.410 0 0
Regulation of TP53 Degradation R-HSA-6804757 4.980214e-02 1.303 0 0
GPVI-mediated activation cascade R-HSA-114604 4.980214e-02 1.303 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 5.115002e-02 1.291 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 5.126616e-02 1.290 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 5.141398e-02 1.289 0 0
Proteasome assembly R-HSA-9907900 5.172675e-02 1.286 0 0
Meiosis R-HSA-1500620 5.179190e-02 1.286 0 0
FGFR1 mutant receptor activation R-HSA-1839124 5.201557e-02 1.284 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 5.201557e-02 1.284 1 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 5.209290e-02 1.283 0 0
Platelet activation, signaling and aggregation R-HSA-76002 5.217454e-02 1.283 0 0
Rab regulation of trafficking R-HSA-9007101 5.231167e-02 1.281 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 5.234268e-02 1.281 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 5.234268e-02 1.281 0 0
Late Phase of HIV Life Cycle R-HSA-162599 5.235401e-02 1.281 0 0
ER to Golgi Anterograde Transport R-HSA-199977 5.284212e-02 1.277 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 5.333468e-02 1.273 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 5.456221e-02 1.263 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 5.526855e-02 1.258 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 5.721302e-02 1.243 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 5.721302e-02 1.243 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 5.721302e-02 1.243 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 5.721302e-02 1.243 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 5.734001e-02 1.242 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 5.745900e-02 1.241 0 0
Erythropoietin activates RAS R-HSA-9027284 5.760922e-02 1.240 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 5.760922e-02 1.240 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 5.760922e-02 1.240 0 0
Chaperone Mediated Autophagy R-HSA-9613829 5.804864e-02 1.236 0 0
Platelet sensitization by LDL R-HSA-432142 5.804864e-02 1.236 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 5.880743e-02 1.231 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 5.887928e-02 1.230 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 6.037689e-02 1.219 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 6.037689e-02 1.219 0 0
Vpu mediated degradation of CD4 R-HSA-180534 6.037689e-02 1.219 0 0
Death Receptor Signaling R-HSA-73887 6.108144e-02 1.214 0 0
Signaling by FGFR R-HSA-190236 6.119846e-02 1.213 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 6.188430e-02 1.208 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 6.227086e-02 1.206 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 6.227086e-02 1.206 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 6.227086e-02 1.206 0 0
Viral mRNA Translation R-HSA-192823 6.236321e-02 1.205 0 0
DAP12 signaling R-HSA-2424491 6.325306e-02 1.199 0 0
Macroautophagy R-HSA-1632852 6.417715e-02 1.193 0 0
Inositol phosphate metabolism R-HSA-1483249 6.436697e-02 1.191 0 0
Insulin receptor signalling cascade R-HSA-74751 6.463474e-02 1.190 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 6.484942e-02 1.188 0 0
G alpha (12/13) signalling events R-HSA-416482 6.484942e-02 1.188 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 6.595725e-02 1.181 0 0
ARMS-mediated activation R-HSA-170984 6.673315e-02 1.176 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 6.673315e-02 1.176 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 6.673315e-02 1.176 0 0
mTORC1-mediated signalling R-HSA-166208 6.843080e-02 1.165 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 6.958462e-02 1.157 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 6.958462e-02 1.157 0 0
Autophagy R-HSA-9612973 6.967326e-02 1.157 0 0
Meiotic recombination R-HSA-912446 7.027475e-02 1.153 0 0
E2F mediated regulation of DNA replication R-HSA-113510 7.032749e-02 1.153 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 7.032749e-02 1.153 0 0
Cilium Assembly R-HSA-5617833 7.044116e-02 1.152 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 7.051344e-02 1.152 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 7.051344e-02 1.152 0 0
MTOR signalling R-HSA-165159 7.067822e-02 1.151 0 0
Differentiation of T cells R-HSA-9945266 7.126335e-02 1.147 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 7.126335e-02 1.147 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 7.126335e-02 1.147 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 7.162324e-02 1.145 0 0
EGFR downregulation R-HSA-182971 7.336401e-02 1.135 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 7.359000e-02 1.133 0 0
Interleukin-17 signaling R-HSA-448424 7.399675e-02 1.131 1 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 7.488334e-02 1.126 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 7.505980e-02 1.125 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 7.505980e-02 1.125 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 7.651819e-02 1.116 0 0
Formation of paraxial mesoderm R-HSA-9793380 7.651819e-02 1.116 0 0
Viral Messenger RNA Synthesis R-HSA-168325 7.651819e-02 1.116 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 7.713545e-02 1.113 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 7.713545e-02 1.113 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 7.713545e-02 1.113 0 0
Signaling by FGFR2 R-HSA-5654738 7.798137e-02 1.108 0 0
Signaling by MET R-HSA-6806834 7.798137e-02 1.108 0 0
Neutrophil degranulation R-HSA-6798695 7.894153e-02 1.103 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 7.920593e-02 1.101 1 0
MAPK6/MAPK4 signaling R-HSA-5687128 7.964419e-02 1.099 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 7.965658e-02 1.099 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 7.965658e-02 1.099 0 0
G2/M DNA replication checkpoint R-HSA-69478 8.009344e-02 1.096 0 0
Signaling by WNT R-HSA-195721 8.021349e-02 1.096 0 0
Regulation of mitotic cell cycle R-HSA-453276 8.138685e-02 1.089 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 8.138685e-02 1.089 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 8.138685e-02 1.089 0 0
Interleukin-12 signaling R-HSA-9020591 8.340025e-02 1.079 0 0
Negative regulation of MET activity R-HSA-6807004 8.407552e-02 1.075 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 8.407552e-02 1.075 0 0
DNA strand elongation R-HSA-69190 8.444565e-02 1.073 0 0
Signaling by WNT in cancer R-HSA-4791275 8.444565e-02 1.073 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 1.014688e-01 0.994 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 1.014688e-01 0.994 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 1.014688e-01 0.994 0 0
Regulation of gap junction activity R-HSA-191650 9.419107e-02 1.026 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 9.419107e-02 1.026 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 9.419107e-02 1.026 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 9.419107e-02 1.026 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 1.068056e-01 0.971 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 8.662355e-02 1.062 0 0
MAPK3 (ERK1) activation R-HSA-110056 8.662355e-02 1.062 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 8.662355e-02 1.062 0 0
Folding of actin by CCT/TriC R-HSA-390450 8.662355e-02 1.062 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 1.092540e-01 0.962 0 0
Interleukin-6 signaling R-HSA-1059683 8.794141e-02 1.056 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 8.794141e-02 1.056 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 8.667895e-02 1.062 0 0
CRMPs in Sema3A signaling R-HSA-399956 1.075023e-01 0.969 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 1.038364e-01 0.984 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.038364e-01 0.984 0 0
GAB1 signalosome R-HSA-180292 1.226861e-01 0.911 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.159469e-01 0.936 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 1.159469e-01 0.936 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 9.650502e-02 1.015 0 0
Signaling by EGFR in Cancer R-HSA-1643713 1.253216e-01 0.902 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.024295e-01 0.990 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 8.746831e-02 1.058 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 1.266960e-01 0.897 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 1.140781e-01 0.943 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 9.650502e-02 1.015 0 0
Signaling by FGFR3 R-HSA-5654741 1.002166e-01 0.999 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.002166e-01 0.999 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 1.266960e-01 0.897 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 1.075023e-01 0.969 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.092368e-01 0.962 0 0
Neurexins and neuroligins R-HSA-6794361 1.266960e-01 0.897 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.226861e-01 0.911 0 0
UCH proteinases R-HSA-5689603 1.254999e-01 0.901 0 0
Nuclear RNA decay R-HSA-9930044 9.650502e-02 1.015 0 0
MyD88-independent TLR4 cascade R-HSA-166166 1.136838e-01 0.944 1 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 1.159469e-01 0.936 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 1.136838e-01 0.944 1 0
FLT3 signaling through SRC family kinases R-HSA-9706374 9.419107e-02 1.026 0 0
Bicarbonate transporters R-HSA-425381 1.092540e-01 0.962 0 0
Synaptic adhesion-like molecules R-HSA-8849932 1.226861e-01 0.911 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 1.149941e-01 0.939 0 0
DAG and IP3 signaling R-HSA-1489509 1.002166e-01 0.999 0 0
Breakdown of the nuclear lamina R-HSA-352238 1.014688e-01 0.994 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.580744e-02 1.019 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.580744e-02 1.019 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.102610e-01 0.958 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 9.438000e-02 1.025 0 0
Neurodegenerative Diseases R-HSA-8863678 9.438000e-02 1.025 0 0
Organelle biogenesis and maintenance R-HSA-1852241 8.552586e-02 1.068 0 0
Degradation of CRY and PER proteins R-HSA-9932298 1.073765e-01 0.969 0 0
Circadian clock R-HSA-9909396 1.214184e-01 0.916 0 0
RUNX2 regulates bone development R-HSA-8941326 9.060365e-02 1.043 0 0
Signaling by Hedgehog R-HSA-5358351 1.009273e-01 0.996 0 0
PI3K Cascade R-HSA-109704 1.039595e-01 0.983 0 0
Hedgehog 'on' state R-HSA-5632684 1.240960e-01 0.906 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 1.068056e-01 0.971 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 1.266960e-01 0.897 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 9.557282e-02 1.020 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.179099e-01 0.928 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.060365e-02 1.043 0 0
Degradation of AXIN R-HSA-4641257 1.024295e-01 0.990 0 0
SARS-CoV Infections R-HSA-9679506 1.255428e-01 0.901 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 1.275741e-01 0.894 0 0
Signaling by ALK R-HSA-201556 1.286960e-01 0.890 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.286960e-01 0.890 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.291013e-01 0.889 0 0
IRS-mediated signalling R-HSA-112399 1.292979e-01 0.888 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 1.314408e-01 0.881 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 1.319305e-01 0.880 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 1.319305e-01 0.880 0 0
G2 Phase R-HSA-68911 1.319305e-01 0.880 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 1.319305e-01 0.880 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.319305e-01 0.880 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.326703e-01 0.877 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 1.328835e-01 0.877 0 0
Notch-HLH transcription pathway R-HSA-350054 1.340020e-01 0.873 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 1.340020e-01 0.873 0 0
Interleukin-1 family signaling R-HSA-446652 1.342950e-01 0.872 1 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 1.344422e-01 0.871 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.344422e-01 0.871 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 1.346201e-01 0.871 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.346201e-01 0.871 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.355177e-01 0.868 0 0
Adaptive Immune System R-HSA-1280218 1.363457e-01 0.865 0 0
Type I hemidesmosome assembly R-HSA-446107 1.369683e-01 0.863 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.369683e-01 0.863 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 1.369683e-01 0.863 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 1.369683e-01 0.863 0 0
MET receptor recycling R-HSA-8875656 1.369683e-01 0.863 0 0
XBP1(S) activates chaperone genes R-HSA-381038 1.373464e-01 0.862 0 0
Muscle contraction R-HSA-397014 1.374186e-01 0.862 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.374687e-01 0.862 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.374687e-01 0.862 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.374687e-01 0.862 0 0
Chromosome Maintenance R-HSA-73886 1.378224e-01 0.861 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 1.384833e-01 0.859 0 0
Rap1 signalling R-HSA-392517 1.431509e-01 0.844 0 0
The NLRP3 inflammasome R-HSA-844456 1.431509e-01 0.844 0 0
PCP/CE pathway R-HSA-4086400 1.464955e-01 0.834 0 0
Interleukin-12 family signaling R-HSA-447115 1.475431e-01 0.831 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 1.520621e-01 0.818 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.526047e-01 0.816 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 1.533922e-01 0.814 0 0
Generic Transcription Pathway R-HSA-212436 1.550943e-01 0.809 1 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.551189e-01 0.809 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 1.553096e-01 0.809 1 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.563808e-01 0.806 0 0
Signaling by ERBB4 R-HSA-1236394 1.571608e-01 0.804 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.571608e-01 0.804 0 0
Interleukin-1 signaling R-HSA-9020702 1.577312e-01 0.802 1 1
VEGFR2 mediated vascular permeability R-HSA-5218920 1.583401e-01 0.800 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 1.583401e-01 0.800 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.604072e-01 0.795 0 0
Regulation of TP53 Expression R-HSA-6804754 1.611612e-01 0.793 0 0
Regulation of cortical dendrite branching R-HSA-8985801 1.611612e-01 0.793 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.611612e-01 0.793 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 1.614510e-01 0.792 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 1.614510e-01 0.792 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 1.619482e-01 0.791 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 1.619482e-01 0.791 0 0
Regulation of IFNG signaling R-HSA-877312 1.619482e-01 0.791 0 0
Drug resistance of ALK mutants R-HSA-9700649 1.637722e-01 0.786 0 0
Drug resistance of KIT mutants R-HSA-9669937 1.637722e-01 0.786 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.637722e-01 0.786 0 0
KIT mutants bind TKIs R-HSA-9669921 1.637722e-01 0.786 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.637722e-01 0.786 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.637722e-01 0.786 0 0
ASP-3026-resistant ALK mutants R-HSA-9717264 1.637722e-01 0.786 0 0
crizotinib-resistant ALK mutants R-HSA-9717326 1.637722e-01 0.786 0 0
NVP-TAE684-resistant ALK mutants R-HSA-9717301 1.637722e-01 0.786 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 1.637722e-01 0.786 0 0
lorlatinib-resistant ALK mutants R-HSA-9717329 1.637722e-01 0.786 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.637722e-01 0.786 0 0
ceritinib-resistant ALK mutants R-HSA-9717323 1.637722e-01 0.786 0 0
alectinib-resistant ALK mutants R-HSA-9717316 1.637722e-01 0.786 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 1.637722e-01 0.786 0 0
brigatinib-resistant ALK mutants R-HSA-9717319 1.637722e-01 0.786 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.637722e-01 0.786 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 1.637722e-01 0.786 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 1.637722e-01 0.786 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.637722e-01 0.786 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 1.637722e-01 0.786 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 1.637722e-01 0.786 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 1.637722e-01 0.786 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.637722e-01 0.786 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.637722e-01 0.786 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 1.637722e-01 0.786 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.637722e-01 0.786 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.637722e-01 0.786 0 0
Signaling by FGFR2 in disease R-HSA-5655253 1.638575e-01 0.786 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.651287e-01 0.782 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.651287e-01 0.782 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.667406e-01 0.778 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 1.667406e-01 0.778 0 0
Cellular response to hypoxia R-HSA-1234174 1.680676e-01 0.775 0 0
Telomere Maintenance R-HSA-157579 1.684621e-01 0.773 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 1.687456e-01 0.773 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.693461e-01 0.771 0 0
Calcineurin activates NFAT R-HSA-2025928 1.701100e-01 0.769 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 1.701100e-01 0.769 0 0
Ovarian tumor domain proteases R-HSA-5689896 1.710802e-01 0.767 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 1.739564e-01 0.760 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.739564e-01 0.760 0 0
VEGF ligand-receptor interactions R-HSA-194313 1.739564e-01 0.760 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 1.739564e-01 0.760 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 1.740372e-01 0.759 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 1.778459e-01 0.750 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 1.786402e-01 0.748 0 0
Hedgehog ligand biogenesis R-HSA-5358346 1.786402e-01 0.748 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 1.792945e-01 0.746 1 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 1.792945e-01 0.746 1 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 1.792945e-01 0.746 1 0
Signaling by FGFR1 R-HSA-5654736 1.799385e-01 0.745 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.799385e-01 0.745 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 1.804922e-01 0.744 0 0
Downstream TCR signaling R-HSA-202424 1.806095e-01 0.743 0 0
HCMV Infection R-HSA-9609646 1.823996e-01 0.739 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 1.884965e-01 0.725 0 0
MET promotes cell motility R-HSA-8875878 1.886517e-01 0.724 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.894020e-01 0.723 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 1.924255e-01 0.716 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 1.928827e-01 0.715 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 1.928827e-01 0.715 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.940523e-01 0.712 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.947635e-01 0.710 0 0
Tight junction interactions R-HSA-420029 1.958420e-01 0.708 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 1.958420e-01 0.708 0 0
Glucose metabolism R-HSA-70326 1.962673e-01 0.707 0 0
Developmental Cell Lineages R-HSA-9734767 1.999116e-01 0.699 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 2.045530e-01 0.689 0 0
IRE1alpha activates chaperones R-HSA-381070 2.046184e-01 0.689 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 2.057056e-01 0.687 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 2.057056e-01 0.687 0 0
Josephin domain DUBs R-HSA-5689877 2.057056e-01 0.687 0 0
Regulation of CDH11 function R-HSA-9762292 2.057056e-01 0.687 0 0
PI3K/AKT activation R-HSA-198203 2.057056e-01 0.687 0 0
Signaling by Leptin R-HSA-2586552 2.057056e-01 0.687 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 2.057056e-01 0.687 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 3.007308e-01 0.522 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 3.007308e-01 0.522 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 3.007308e-01 0.522 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 3.007308e-01 0.522 0 0
Diseases of Telomere Maintenance R-HSA-9673013 3.007308e-01 0.522 0 0
SARS-CoV-1 targets PDZ proteins in cell-cell junction R-HSA-9692912 3.007308e-01 0.522 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 3.007308e-01 0.522 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 3.007308e-01 0.522 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 3.007308e-01 0.522 0 0
TICAM1 deficiency - HSE R-HSA-5602566 3.007308e-01 0.522 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 3.007308e-01 0.522 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 3.007308e-01 0.522 0 0
Signaling by FGFR1 amplification mutants R-HSA-1839120 2.254059e-01 0.647 0 0
TRKA activation by NGF R-HSA-187042 2.254059e-01 0.647 0 0
Signaling by FGFR2 amplification mutants R-HSA-2023837 2.254059e-01 0.647 0 0
PLC-gamma1 signalling R-HSA-167021 2.254059e-01 0.647 0 0
MET interacts with TNS proteins R-HSA-8875513 2.254059e-01 0.647 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 2.254059e-01 0.647 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 2.254059e-01 0.647 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 2.254059e-01 0.647 0 0
MET activates PTPN11 R-HSA-8865999 2.254059e-01 0.647 0 0
Neurofascin interactions R-HSA-447043 2.191069e-01 0.659 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.191069e-01 0.659 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 2.191069e-01 0.659 0 0
Erythropoietin activates STAT5 R-HSA-9027283 2.191069e-01 0.659 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 2.191069e-01 0.659 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 2.911121e-01 0.536 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 2.911121e-01 0.536 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 2.911121e-01 0.536 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.911121e-01 0.536 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 2.911121e-01 0.536 0 0
Nef mediated downregulation of CD28 cell surface expression R-HSA-164939 4.152647e-01 0.382 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 4.152647e-01 0.382 0 0
t(4;14) translocations of FGFR3 R-HSA-2033515 4.152647e-01 0.382 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 4.152647e-01 0.382 0 0
Signaling by FGFR3 fusions in cancer R-HSA-8853334 4.152647e-01 0.382 0 0
Signaling by FGFR2 fusions R-HSA-8853333 4.152647e-01 0.382 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 4.152647e-01 0.382 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 4.152647e-01 0.382 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 4.152647e-01 0.382 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 4.152647e-01 0.382 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 4.152647e-01 0.382 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 4.152647e-01 0.382 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 4.152647e-01 0.382 0 0
IKBKB deficiency causes SCID R-HSA-5602636 4.152647e-01 0.382 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 4.152647e-01 0.382 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 4.152647e-01 0.382 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 4.152647e-01 0.382 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 4.152647e-01 0.382 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 4.152647e-01 0.382 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 4.152647e-01 0.382 0 0
TRAF3 deficiency - HSE R-HSA-5602571 4.152647e-01 0.382 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5619101 4.152647e-01 0.382 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 4.152647e-01 0.382 0 0
Defective VWF binding to collagen type I R-HSA-9845622 4.152647e-01 0.382 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5660686 4.152647e-01 0.382 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 4.152647e-01 0.382 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 4.152647e-01 0.382 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 4.152647e-01 0.382 0 0
Activation of TRKA receptors R-HSA-187015 2.662802e-01 0.575 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 2.662802e-01 0.575 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 2.662802e-01 0.575 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.662802e-01 0.575 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 2.662802e-01 0.575 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 2.662802e-01 0.575 0 0
PTK6 Expression R-HSA-8849473 2.662802e-01 0.575 0 0
IFNG signaling activates MAPKs R-HSA-9732724 2.662802e-01 0.575 0 0
SOS-mediated signalling R-HSA-112412 2.662802e-01 0.575 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 2.662802e-01 0.575 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 2.432077e-01 0.614 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 3.560787e-01 0.448 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 3.560787e-01 0.448 0 0
Co-inhibition by BTLA R-HSA-9927353 3.560787e-01 0.448 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 3.560787e-01 0.448 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 3.144800e-01 0.502 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 3.144800e-01 0.502 0 0
Interleukin-18 signaling R-HSA-9012546 3.144800e-01 0.502 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 3.144800e-01 0.502 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 3.144800e-01 0.502 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 2.820715e-01 0.550 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 2.820715e-01 0.550 0 0
Spry regulation of FGF signaling R-HSA-1295596 2.554039e-01 0.593 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.554039e-01 0.593 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 2.327524e-01 0.633 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 2.131136e-01 0.671 1 1
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 2.891139e-01 0.539 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 2.891139e-01 0.539 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 2.891139e-01 0.539 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 2.891139e-01 0.539 0 0
MET activates RAS signaling R-HSA-8851805 3.217743e-01 0.492 0 0
p75NTR recruits signalling complexes R-HSA-209543 3.217743e-01 0.492 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 3.217743e-01 0.492 0 0
Leading Strand Synthesis R-HSA-69109 3.217743e-01 0.492 0 0
Polymerase switching R-HSA-69091 3.217743e-01 0.492 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 3.217743e-01 0.492 0 0
Scavenging by Class F Receptors R-HSA-3000484 3.217743e-01 0.492 0 0
Lipophagy R-HSA-9613354 3.628380e-01 0.440 0 0
Interleukin-21 signaling R-HSA-9020958 3.628380e-01 0.440 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 3.628380e-01 0.440 0 0
WNT mediated activation of DVL R-HSA-201688 3.628380e-01 0.440 0 0
Signaling by FGFR3 in disease R-HSA-5655332 2.424899e-01 0.615 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 3.235498e-01 0.490 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 2.670894e-01 0.573 0 0
CD28 dependent Vav1 pathway R-HSA-389359 3.618295e-01 0.441 0 0
2-LTR circle formation R-HSA-164843 4.106230e-01 0.387 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 4.106230e-01 0.387 0 0
DNA replication initiation R-HSA-68952 4.106230e-01 0.387 0 0
Regulation of PTEN stability and activity R-HSA-8948751 2.100617e-01 0.678 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.100617e-01 0.678 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 3.208699e-01 0.494 0 0
Retrograde neurotrophin signalling R-HSA-177504 4.017960e-01 0.396 0 0
Dual Incision in GG-NER R-HSA-5696400 3.150982e-01 0.502 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 3.492826e-01 0.457 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 3.117744e-01 0.506 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 3.395447e-01 0.469 0 0
FGFR2 alternative splicing R-HSA-6803529 3.854026e-01 0.414 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 3.779451e-01 0.423 0 0
HIV elongation arrest and recovery R-HSA-167287 4.066956e-01 0.391 0 0
Pausing and recovery of HIV elongation R-HSA-167290 4.066956e-01 0.391 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 3.975711e-01 0.401 0 0
Transcription of the HIV genome R-HSA-167172 3.863571e-01 0.413 0 0
Nucleotide Excision Repair R-HSA-5696398 2.121970e-01 0.673 0 0
FGFR2 mutant receptor activation R-HSA-1839126 3.642798e-01 0.439 0 0
G-protein beta:gamma signalling R-HSA-397795 3.975711e-01 0.401 0 0
Interleukin-23 signaling R-HSA-9020933 3.144800e-01 0.502 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 2.131136e-01 0.671 0 0
ER-Phagosome pathway R-HSA-1236974 3.074076e-01 0.512 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 2.920906e-01 0.534 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.260839e-01 0.646 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 2.424899e-01 0.615 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 3.492826e-01 0.457 0 0
Interleukin-6 family signaling R-HSA-6783589 2.928751e-01 0.533 0 0
Antigen processing-Cross presentation R-HSA-1236975 2.486853e-01 0.604 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 3.217743e-01 0.492 0 0
TGFBR3 expression R-HSA-9839394 3.208699e-01 0.494 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 3.586440e-01 0.445 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 2.820715e-01 0.550 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 3.235498e-01 0.490 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 3.854026e-01 0.414 0 0
Signaling by FGFR4 R-HSA-5654743 2.086174e-01 0.681 0 0
DCC mediated attractive signaling R-HSA-418885 2.554039e-01 0.593 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 3.975711e-01 0.401 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 2.911121e-01 0.536 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 2.424899e-01 0.615 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 2.869467e-01 0.542 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 2.388259e-01 0.622 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.584145e-01 0.588 0 0
NTRK3 as a dependence receptor R-HSA-9603505 4.152647e-01 0.382 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 3.217743e-01 0.492 0 0
Growth hormone receptor signaling R-HSA-982772 2.654697e-01 0.576 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 3.235498e-01 0.490 0 0
Formation of axial mesoderm R-HSA-9796292 3.618295e-01 0.441 0 0
STING mediated induction of host immune responses R-HSA-1834941 2.619820e-01 0.582 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 3.492826e-01 0.457 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 3.565609e-01 0.448 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 3.591393e-01 0.445 1 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 3.780402e-01 0.422 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 3.253665e-01 0.488 0 0
PLC beta mediated events R-HSA-112043 2.592842e-01 0.586 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 2.191069e-01 0.659 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 2.614056e-01 0.583 1 0
Beta-catenin independent WNT signaling R-HSA-3858494 4.020361e-01 0.396 0 0
G-protein mediated events R-HSA-112040 2.737380e-01 0.563 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 2.200148e-01 0.658 1 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 2.460236e-01 0.609 1 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 3.560787e-01 0.448 0 0
Pyrophosphate hydrolysis R-HSA-71737 3.560787e-01 0.448 0 0
Signaling by FGFR4 in disease R-HSA-5655291 2.227504e-01 0.652 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 2.227504e-01 0.652 0 0
Disorders of Developmental Biology R-HSA-9675151 3.235498e-01 0.490 0 0
Ca-dependent events R-HSA-111996 2.870137e-01 0.542 0 0
NOD1/2 Signaling Pathway R-HSA-168638 3.150982e-01 0.502 1 1
Intraflagellar transport R-HSA-5620924 3.047954e-01 0.516 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 2.486853e-01 0.604 1 0
DNA Repair R-HSA-73894 3.263504e-01 0.486 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 2.138673e-01 0.670 0 0
Calmodulin induced events R-HSA-111933 2.455839e-01 0.610 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.675063e-01 0.573 0 0
Cellular response to starvation R-HSA-9711097 2.869467e-01 0.542 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 3.933450e-01 0.405 0 0
Opioid Signalling R-HSA-111885 4.047414e-01 0.393 0 0
CaM pathway R-HSA-111997 2.455839e-01 0.610 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 2.458238e-01 0.609 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 3.492826e-01 0.457 0 0
p38MAPK events R-HSA-171007 2.554039e-01 0.593 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 2.554039e-01 0.593 0 0
Disorders of Nervous System Development R-HSA-9697154 3.217743e-01 0.492 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 3.217743e-01 0.492 0 0
Pervasive developmental disorders R-HSA-9005895 3.217743e-01 0.492 0 0
Ion homeostasis R-HSA-5578775 3.608611e-01 0.443 0 0
Adrenoceptors R-HSA-390696 3.144800e-01 0.502 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 2.388259e-01 0.622 0 0
Negative regulation of FLT3 R-HSA-9706369 2.891139e-01 0.539 0 0
Mitochondrial biogenesis R-HSA-1592230 3.995926e-01 0.398 0 0
Inflammasomes R-HSA-622312 2.670894e-01 0.573 0 0
TBC/RABGAPs R-HSA-8854214 3.083187e-01 0.511 0 0
Heme signaling R-HSA-9707616 3.741637e-01 0.427 0 0
PTK6 Activates STAT3 R-HSA-8849474 3.560787e-01 0.448 0 0
Protein methylation R-HSA-8876725 2.554039e-01 0.593 0 0
DAP12 interactions R-HSA-2172127 2.267583e-01 0.644 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 3.975711e-01 0.401 0 0
Protein ubiquitination R-HSA-8852135 3.207351e-01 0.494 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 3.326965e-01 0.478 0 0
Gastrulation R-HSA-9758941 3.060533e-01 0.514 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 3.007308e-01 0.522 0 0
Inhibition of PKR R-HSA-169131 3.007308e-01 0.522 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 2.254059e-01 0.647 0 0
MTF1 activates gene expression R-HSA-5660489 2.911121e-01 0.536 0 0
ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 4.152647e-01 0.382 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 4.152647e-01 0.382 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 4.152647e-01 0.382 0 0
Transport of connexins along the secretory pathway R-HSA-190827 4.152647e-01 0.382 0 0
Manipulation of host energy metabolism R-HSA-9636667 4.152647e-01 0.382 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 4.152647e-01 0.382 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 2.820715e-01 0.550 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 2.891139e-01 0.539 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 3.618295e-01 0.441 0 0
Maturation of nucleoprotein R-HSA-9683610 3.618295e-01 0.441 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 2.267583e-01 0.644 0 0
Interleukin-1 processing R-HSA-448706 3.628380e-01 0.440 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 2.662802e-01 0.575 0 0
Interleukin-37 signaling R-HSA-9008059 3.181870e-01 0.497 0 0
Reproduction R-HSA-1474165 3.811112e-01 0.419 0 0
Oligomerization of connexins into connexons R-HSA-190704 4.152647e-01 0.382 0 0
Inhibition of membrane repair R-HSA-9635644 4.152647e-01 0.382 0 0
MAPK1 (ERK2) activation R-HSA-112411 3.628380e-01 0.440 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 2.136987e-01 0.670 0 0
Interleukin-2 signaling R-HSA-9020558 2.432077e-01 0.614 0 0
NrCAM interactions R-HSA-447038 3.560787e-01 0.448 0 0
Sensory processing of sound R-HSA-9659379 2.216657e-01 0.654 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 3.060685e-01 0.514 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 4.159383e-01 0.381 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 4.167756e-01 0.380 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 4.178068e-01 0.379 0 0
NGF-independant TRKA activation R-HSA-187024 4.187860e-01 0.378 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 4.187860e-01 0.378 0 0
Phosphorylation of Emi1 R-HSA-176417 4.187860e-01 0.378 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 4.187860e-01 0.378 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 4.187860e-01 0.378 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 4.187860e-01 0.378 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 4.187860e-01 0.378 0 0
Signaling by MAPK mutants R-HSA-9652817 4.187860e-01 0.378 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 4.187860e-01 0.378 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 4.187860e-01 0.378 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 4.187860e-01 0.378 0 0
Proton/oligopeptide cotransporters R-HSA-427975 4.187860e-01 0.378 0 0
NGF-stimulated transcription R-HSA-9031628 4.189058e-01 0.378 0 0
Activation of HOX genes during differentiation R-HSA-5619507 4.202593e-01 0.376 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 4.202593e-01 0.376 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 4.226081e-01 0.374 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 4.281285e-01 0.368 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 4.281285e-01 0.368 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 4.286363e-01 0.368 1 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 4.286363e-01 0.368 1 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 4.350713e-01 0.361 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 4.353803e-01 0.361 0 0
Late endosomal microautophagy R-HSA-9615710 4.353803e-01 0.361 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 4.353803e-01 0.361 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 4.353803e-01 0.361 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 4.412843e-01 0.355 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 4.412843e-01 0.355 0 0
p75NTR signals via NF-kB R-HSA-193639 4.412843e-01 0.355 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 4.412843e-01 0.355 0 0
Deadenylation of mRNA R-HSA-429947 4.479502e-01 0.349 0 0
Netrin-1 signaling R-HSA-373752 4.521344e-01 0.345 0 0
Potential therapeutics for SARS R-HSA-9679191 4.550485e-01 0.342 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 4.572383e-01 0.340 0 0
PI Metabolism R-HSA-1483255 4.596124e-01 0.338 0 0
Signaling by Insulin receptor R-HSA-74752 4.605178e-01 0.337 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 4.624942e-01 0.335 0 0
Signal transduction by L1 R-HSA-445144 4.624942e-01 0.335 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 4.638549e-01 0.334 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 4.638549e-01 0.334 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 4.638549e-01 0.334 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 4.640019e-01 0.333 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 4.723365e-01 0.326 1 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 4.723365e-01 0.326 1 0
HCMV Late Events R-HSA-9610379 4.738659e-01 0.324 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 4.739613e-01 0.324 0 0
Oncogene Induced Senescence R-HSA-2559585 4.771642e-01 0.321 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 4.782317e-01 0.320 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 4.782317e-01 0.320 0 0
Signaling by LTK in cancer R-HSA-9842640 4.782317e-01 0.320 0 0
Autointegration results in viral DNA circles R-HSA-177539 4.782317e-01 0.320 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 4.782317e-01 0.320 0 0
CREB phosphorylation R-HSA-199920 4.782317e-01 0.320 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 4.782317e-01 0.320 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 4.782317e-01 0.320 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 4.787496e-01 0.320 0 0
Interleukin-7 signaling R-HSA-1266695 4.787496e-01 0.320 0 0
Phosphorylation of the APC/C R-HSA-176412 4.799586e-01 0.319 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 4.799586e-01 0.319 0 0
Killing mechanisms R-HSA-9664420 4.799586e-01 0.319 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 4.799586e-01 0.319 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 4.799586e-01 0.319 0 0
Activation of SMO R-HSA-5635838 4.799586e-01 0.319 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 4.799586e-01 0.319 0 0
Signaling by PDGF R-HSA-186797 4.833489e-01 0.316 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 4.886356e-01 0.311 0 0
Trafficking of AMPA receptors R-HSA-399719 4.919865e-01 0.308 0 0
Lagging Strand Synthesis R-HSA-69186 4.962211e-01 0.304 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 4.962211e-01 0.304 0 0
Early Phase of HIV Life Cycle R-HSA-162594 4.962211e-01 0.304 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 4.987409e-01 0.302 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 4.987409e-01 0.302 0 0
Signaling by TGFBR3 R-HSA-9839373 4.987409e-01 0.302 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 5.022138e-01 0.299 0 0
Integration of provirus R-HSA-162592 5.022138e-01 0.299 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 5.022138e-01 0.299 0 0
ERKs are inactivated R-HSA-202670 5.022138e-01 0.299 0 0
FLT3 signaling in disease R-HSA-9682385 5.032018e-01 0.298 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 5.110444e-01 0.292 0 0
NTF3 activates NTRK2 (TRKB) signaling R-HSA-9025046 5.110444e-01 0.292 0 0
DSCAM interactions R-HSA-376172 5.110444e-01 0.292 0 0
NTF4 activates NTRK2 (TRKB) signaling R-HSA-9026357 5.110444e-01 0.292 0 0
BDNF activates NTRK2 (TRKB) signaling R-HSA-9024909 5.110444e-01 0.292 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 5.110444e-01 0.292 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 5.110444e-01 0.292 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 5.110444e-01 0.292 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 5.110444e-01 0.292 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 5.110444e-01 0.292 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 5.110444e-01 0.292 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 5.110444e-01 0.292 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 5.110444e-01 0.292 0 0
Glycogen storage disease type IV (GBE1) R-HSA-3878781 5.110444e-01 0.292 0 0
mRNA Editing: A to I Conversion R-HSA-75064 5.110444e-01 0.292 0 0
The AIM2 inflammasome R-HSA-844615 5.110444e-01 0.292 0 0
C6 deamination of adenosine R-HSA-75102 5.110444e-01 0.292 0 0
Diseases of cellular response to stress R-HSA-9675132 5.110444e-01 0.292 0 0
Diseases of Cellular Senescence R-HSA-9630747 5.110444e-01 0.292 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 5.110444e-01 0.292 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 5.175371e-01 0.286 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 5.175371e-01 0.286 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 5.175371e-01 0.286 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 5.175371e-01 0.286 0 0
Unfolded Protein Response (UPR) R-HSA-381119 5.179659e-01 0.286 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 5.185581e-01 0.285 0 0
rRNA processing R-HSA-72312 5.244705e-01 0.280 0 0
Amyloid fiber formation R-HSA-977225 5.253058e-01 0.280 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 5.288256e-01 0.277 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 5.291176e-01 0.276 0 0
Attachment and Entry R-HSA-9694614 5.291176e-01 0.276 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 5.305099e-01 0.275 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 5.338019e-01 0.273 0 0
Regulation of PTEN localization R-HSA-8948747 5.338019e-01 0.273 0 0
Disinhibition of SNARE formation R-HSA-114516 5.338019e-01 0.273 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 5.338019e-01 0.273 0 0
CHL1 interactions R-HSA-447041 5.338019e-01 0.273 0 0
SLC-mediated transport of oligopeptides R-HSA-9959399 5.338019e-01 0.273 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 5.338019e-01 0.273 0 0
MECP2 regulates transcription factors R-HSA-9022707 5.338019e-01 0.273 0 0
Signaling by NOTCH1 R-HSA-1980143 5.370037e-01 0.270 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 5.386055e-01 0.269 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 5.386055e-01 0.269 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 5.386055e-01 0.269 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 5.451947e-01 0.263 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 5.451947e-01 0.263 0 0
Repression of WNT target genes R-HSA-4641265 5.451947e-01 0.263 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 5.451947e-01 0.263 0 0
Interleukin-35 Signalling R-HSA-8984722 5.451947e-01 0.263 0 0
VLDLR internalisation and degradation R-HSA-8866427 5.451947e-01 0.263 0 0
Interleukin-15 signaling R-HSA-8983432 5.451947e-01 0.263 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 5.467487e-01 0.262 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 5.537904e-01 0.257 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 5.537904e-01 0.257 0 0
Specification of primordial germ cells R-HSA-9827857 5.537904e-01 0.257 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 5.551978e-01 0.256 0 0
Metabolism of polyamines R-HSA-351202 5.570441e-01 0.254 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 5.586998e-01 0.253 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 5.610214e-01 0.251 0 0
Selenoamino acid metabolism R-HSA-2408522 5.624493e-01 0.250 0 0
DNA Damage Bypass R-HSA-73893 5.663996e-01 0.247 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 5.673994e-01 0.246 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 5.673994e-01 0.246 0 0
Formation of the Early Elongation Complex R-HSA-113418 5.673994e-01 0.246 0 0
Pyroptosis R-HSA-5620971 5.673994e-01 0.246 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 5.702393e-01 0.244 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 5.731751e-01 0.242 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 5.784940e-01 0.238 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 5.819170e-01 0.235 0 0
RSK activation R-HSA-444257 5.851715e-01 0.233 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 5.851715e-01 0.233 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 5.851715e-01 0.233 0 0
Co-stimulation by ICOS R-HSA-9927354 5.851715e-01 0.233 0 0
TGFBR3 PTM regulation R-HSA-9839383 5.851715e-01 0.233 0 0
FGFR3 mutant receptor activation R-HSA-2033514 5.859275e-01 0.232 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 5.859275e-01 0.232 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 5.859275e-01 0.232 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 5.859275e-01 0.232 1 1
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 5.859275e-01 0.232 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 5.859275e-01 0.232 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 5.885384e-01 0.230 0 0
Tie2 Signaling R-HSA-210993 5.885384e-01 0.230 0 0
Polo-like kinase mediated events R-HSA-156711 5.885384e-01 0.230 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 5.905980e-01 0.229 0 0
The NLRP1 inflammasome R-HSA-844455 5.911399e-01 0.228 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 5.911399e-01 0.228 0 0
Axonal growth stimulation R-HSA-209563 5.911399e-01 0.228 0 0
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336 5.911399e-01 0.228 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 5.911399e-01 0.228 0 0
Defective DPM2 causes DPM2-CDG R-HSA-4719377 5.911399e-01 0.228 0 0
Classical Kir channels R-HSA-1296053 5.911399e-01 0.228 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 5.911399e-01 0.228 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 5.911399e-01 0.228 0 0
Defective DPM3 causes DPM3-CDG R-HSA-4719360 5.911399e-01 0.228 0 0
Defective DPM1 causes DPM1-CDG R-HSA-4717374 5.911399e-01 0.228 0 0
Signalling to STAT3 R-HSA-198745 5.911399e-01 0.228 0 0
Invadopodia formation R-HSA-8941237 5.911399e-01 0.228 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 5.911399e-01 0.228 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 5.911399e-01 0.228 0 0
MET activates STAT3 R-HSA-8875791 5.911399e-01 0.228 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 5.911399e-01 0.228 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 5.911399e-01 0.228 0 0
Activation of BMF and translocation to mitochondria R-HSA-139910 5.911399e-01 0.228 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 5.911399e-01 0.228 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 5.911399e-01 0.228 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 5.911399e-01 0.228 0 0
Syndecan interactions R-HSA-3000170 5.917987e-01 0.228 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 5.925139e-01 0.227 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 5.952930e-01 0.225 0 0
Termination of translesion DNA synthesis R-HSA-5656169 5.952930e-01 0.225 0 0
DARPP-32 events R-HSA-180024 5.952930e-01 0.225 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 5.988504e-01 0.223 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 5.988504e-01 0.223 0 0
HIV Transcription Elongation R-HSA-167169 6.023933e-01 0.220 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 6.023933e-01 0.220 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 6.023933e-01 0.220 0 0
Glycogen metabolism R-HSA-8982491 6.023933e-01 0.220 0 0
Cellular response to chemical stress R-HSA-9711123 6.031103e-01 0.220 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 6.082373e-01 0.216 0 0
Hemostasis R-HSA-109582 6.122636e-01 0.213 0 0
Immune System R-HSA-168256 6.146948e-01 0.211 1 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 6.213430e-01 0.207 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 6.213430e-01 0.207 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 6.213430e-01 0.207 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 6.216459e-01 0.206 0 0
Translesion Synthesis by POLH R-HSA-110320 6.216459e-01 0.206 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 6.216459e-01 0.206 0 0
Maturation of nucleoprotein R-HSA-9694631 6.216459e-01 0.206 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 6.237047e-01 0.205 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 6.242459e-01 0.205 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 6.242459e-01 0.205 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 6.242459e-01 0.205 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 6.242459e-01 0.205 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 6.242459e-01 0.205 0 0
Regulation of TNFR1 signaling R-HSA-5357905 6.277017e-01 0.202 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 6.322254e-01 0.199 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 6.322254e-01 0.199 0 0
p75NTR regulates axonogenesis R-HSA-193697 6.322254e-01 0.199 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 6.322254e-01 0.199 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 6.322254e-01 0.199 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 6.322254e-01 0.199 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 6.322254e-01 0.199 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 6.322254e-01 0.199 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 6.322254e-01 0.199 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 6.339690e-01 0.198 0 0
Signaling by Nuclear Receptors R-HSA-9006931 6.367584e-01 0.196 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 6.476800e-01 0.189 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 6.480292e-01 0.188 0 0
HIV Transcription Initiation R-HSA-167161 6.480292e-01 0.188 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 6.480292e-01 0.188 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 6.490698e-01 0.188 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 6.495733e-01 0.187 0 0
Acyl chain remodelling of PS R-HSA-1482801 6.495733e-01 0.187 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 6.495733e-01 0.187 0 0
HDMs demethylate histones R-HSA-3214842 6.495733e-01 0.187 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 6.514059e-01 0.186 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 6.522652e-01 0.186 0 0
Signaling by NODAL R-HSA-1181150 6.530192e-01 0.185 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 6.581188e-01 0.182 0 0
Nucleotide catabolism defects R-HSA-9735786 6.581188e-01 0.182 0 0
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine R-HSA-9735763 6.581188e-01 0.182 0 0
Signaling by MAP2K mutants R-HSA-9652169 6.581188e-01 0.182 0 0
MDK and PTN in ALK signaling R-HSA-9851151 6.581188e-01 0.182 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 6.581188e-01 0.182 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 6.581188e-01 0.182 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 6.581188e-01 0.182 0 0
NADE modulates death signalling R-HSA-205025 6.581188e-01 0.182 0 0
Sensory perception of sour taste R-HSA-9729555 6.581188e-01 0.182 0 0
Interleukin-38 signaling R-HSA-9007892 6.581188e-01 0.182 0 0
Processive synthesis on the lagging strand R-HSA-69183 6.600575e-01 0.180 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 6.600575e-01 0.180 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 6.600575e-01 0.180 0 0
SHC1 events in EGFR signaling R-HSA-180336 6.600575e-01 0.180 0 0
Translesion synthesis by REV1 R-HSA-110312 6.600575e-01 0.180 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 6.600575e-01 0.180 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 6.619438e-01 0.179 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 6.696763e-01 0.174 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 6.749991e-01 0.171 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 6.749991e-01 0.171 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 6.749991e-01 0.171 0 0
Interleukin-27 signaling R-HSA-9020956 6.749991e-01 0.171 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 6.749991e-01 0.171 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 6.749991e-01 0.171 0 0
Receptor Mediated Mitophagy R-HSA-8934903 6.749991e-01 0.171 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 6.749991e-01 0.171 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 6.764319e-01 0.170 0 0
Metalloprotease DUBs R-HSA-5689901 6.764319e-01 0.170 0 0
FOXO-mediated transcription R-HSA-9614085 6.782928e-01 0.169 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 6.826002e-01 0.166 0 0
FGFR2 ligand binding and activation R-HSA-190241 6.826002e-01 0.166 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 6.826002e-01 0.166 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 6.826002e-01 0.166 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 6.904978e-01 0.161 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 6.928218e-01 0.159 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 6.928218e-01 0.159 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 6.928218e-01 0.159 0 0
Translesion synthesis by POLI R-HSA-5656121 6.933305e-01 0.159 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 6.933305e-01 0.159 0 0
Interferon alpha/beta signaling R-HSA-909733 6.959357e-01 0.157 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 7.018822e-01 0.154 0 0
TNF signaling R-HSA-75893 7.063866e-01 0.151 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 7.103625e-01 0.149 0 0
Mitochondrial calcium ion transport R-HSA-8949215 7.103625e-01 0.149 0 0
RMTs methylate histone arginines R-HSA-3214858 7.104700e-01 0.148 0 0
Platelet degranulation R-HSA-114608 7.106439e-01 0.148 0 0
Formation of the posterior neural plate R-HSA-9832991 7.136320e-01 0.147 0 0
FGFR2b ligand binding and activation R-HSA-190377 7.136320e-01 0.147 0 0
Ionotropic activity of kainate receptors R-HSA-451306 7.136320e-01 0.147 0 0
Synthesis of PI R-HSA-1483226 7.136320e-01 0.147 0 0
Suppression of apoptosis R-HSA-9635465 7.136320e-01 0.147 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.136320e-01 0.147 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 7.136320e-01 0.147 0 0
PTK6 Down-Regulation R-HSA-8849472 7.141285e-01 0.146 0 0
NTRK2 activates RAC1 R-HSA-9032759 7.141285e-01 0.146 0 0
FGFR1c and Klotho ligand binding and activation R-HSA-190374 7.141285e-01 0.146 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 7.141285e-01 0.146 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 7.141285e-01 0.146 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 7.141285e-01 0.146 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 7.141285e-01 0.146 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 7.141285e-01 0.146 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 7.141285e-01 0.146 0 0
Activation of AKT2 R-HSA-165158 7.141285e-01 0.146 0 0
Reelin signalling pathway R-HSA-8866376 7.141285e-01 0.146 0 0
Suppression of autophagy R-HSA-9636569 7.141285e-01 0.146 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 7.141285e-01 0.146 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 7.141285e-01 0.146 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 7.141285e-01 0.146 0 0
Infectious disease R-HSA-5663205 7.192065e-01 0.143 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 7.199275e-01 0.143 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 7.240819e-01 0.140 0 0
Translesion synthesis by POLK R-HSA-5655862 7.240819e-01 0.140 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 7.240819e-01 0.140 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 7.259067e-01 0.139 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 7.259067e-01 0.139 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 7.295768e-01 0.137 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 7.363065e-01 0.133 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 7.363065e-01 0.133 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 7.363065e-01 0.133 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 7.401078e-01 0.131 0 0
Mitophagy R-HSA-5205647 7.401078e-01 0.131 0 0
Dual incision in TC-NER R-HSA-6782135 7.405939e-01 0.130 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 7.405939e-01 0.130 0 0
Toll-like Receptor Cascades R-HSA-168898 7.426991e-01 0.129 1 0
Leishmania phagocytosis R-HSA-9664417 7.460187e-01 0.127 0 0
Parasite infection R-HSA-9664407 7.460187e-01 0.127 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 7.460187e-01 0.127 0 0
Diseases of DNA repair R-HSA-9675135 7.478091e-01 0.126 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 7.480240e-01 0.126 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 7.483326e-01 0.126 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 7.483326e-01 0.126 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 7.483326e-01 0.126 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 7.483326e-01 0.126 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 7.483326e-01 0.126 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 7.483326e-01 0.126 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 7.483326e-01 0.126 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 7.483326e-01 0.126 0 0
mRNA Capping R-HSA-72086 7.485042e-01 0.126 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 7.485042e-01 0.126 0 0
Regulation of gene expression in beta cells R-HSA-210745 7.485042e-01 0.126 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 7.523673e-01 0.124 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 7.523673e-01 0.124 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 7.523673e-01 0.124 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 7.523673e-01 0.124 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 7.523673e-01 0.124 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 7.523673e-01 0.124 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 7.531418e-01 0.123 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 7.565334e-01 0.121 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 7.604549e-01 0.119 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 7.604549e-01 0.119 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 7.604549e-01 0.119 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 7.604549e-01 0.119 0 0
Interleukin-20 family signaling R-HSA-8854691 7.604549e-01 0.119 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 7.609649e-01 0.119 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 7.609649e-01 0.119 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 7.609649e-01 0.119 0 0
Cam-PDE 1 activation R-HSA-111957 7.609649e-01 0.119 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 7.609649e-01 0.119 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 7.609649e-01 0.119 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 7.609649e-01 0.119 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 7.609649e-01 0.119 0 0
Pentose phosphate pathway disease R-HSA-6791465 7.609649e-01 0.119 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 7.609649e-01 0.119 0 0
Synthesis of dolichyl-phosphate mannose R-HSA-162699 7.609649e-01 0.119 0 0
Synthesis of PS R-HSA-1483101 7.609649e-01 0.119 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 7.609649e-01 0.119 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 7.609649e-01 0.119 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 7.609649e-01 0.119 0 0
TRAIL signaling R-HSA-75158 7.609649e-01 0.119 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 7.609649e-01 0.119 0 0
ABC transporter disorders R-HSA-5619084 7.634388e-01 0.117 0 0
Parasitic Infection Pathways R-HSA-9824443 7.653702e-01 0.116 0 0
Leishmania infection R-HSA-9658195 7.653702e-01 0.116 0 0
Adipogenesis R-HSA-9843745 7.668377e-01 0.115 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 7.696878e-01 0.114 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 7.696878e-01 0.114 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 7.712428e-01 0.113 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 7.720108e-01 0.112 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 7.720108e-01 0.112 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 7.720108e-01 0.112 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 7.720108e-01 0.112 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 7.720108e-01 0.112 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 7.782716e-01 0.109 0 0
Activated point mutants of FGFR2 R-HSA-2033519 7.782716e-01 0.109 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 7.782716e-01 0.109 0 0
Mismatch Repair R-HSA-5358508 7.782716e-01 0.109 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 7.782716e-01 0.109 0 0
Presynaptic function of Kainate receptors R-HSA-500657 7.782716e-01 0.109 0 0
GRB2 events in EGFR signaling R-HSA-179812 7.793524e-01 0.108 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 7.793524e-01 0.108 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 7.793524e-01 0.108 0 0
OAS antiviral response R-HSA-8983711 7.793524e-01 0.108 0 0
GPER1 signaling R-HSA-9634597 7.816455e-01 0.107 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 7.828487e-01 0.106 0 0
G alpha (z) signalling events R-HSA-418597 7.914284e-01 0.102 0 0
Signaling by NOTCH3 R-HSA-9012852 7.914284e-01 0.102 0 0
Regulated Necrosis R-HSA-5218859 7.963457e-01 0.099 0 0
STAT5 Activation R-HSA-9645135 8.001300e-01 0.097 0 0
Metabolism of ingested MeSeO2H into MeSeH R-HSA-5263617 8.001300e-01 0.097 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 8.001300e-01 0.097 0 0
MET Receptor Activation R-HSA-6806942 8.001300e-01 0.097 0 0
Abacavir transmembrane transport R-HSA-2161517 8.001300e-01 0.097 0 0
HDL clearance R-HSA-8964011 8.001300e-01 0.097 0 0
VLDL assembly R-HSA-8866423 8.001300e-01 0.097 0 0
Leukotriene receptors R-HSA-391906 8.001300e-01 0.097 0 0
NCAM signaling for neurite out-growth R-HSA-375165 8.006330e-01 0.097 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 8.019013e-01 0.096 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 8.019013e-01 0.096 0 0
Germ layer formation at gastrulation R-HSA-9754189 8.019013e-01 0.096 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 8.019013e-01 0.096 0 0
Specification of the neural plate border R-HSA-9834899 8.019013e-01 0.096 0 0
Other interleukin signaling R-HSA-449836 8.019013e-01 0.096 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 8.019013e-01 0.096 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 8.035438e-01 0.095 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 8.044772e-01 0.094 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 8.069658e-01 0.093 0 0
FGFR2c ligand binding and activation R-HSA-190375 8.069658e-01 0.093 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.069658e-01 0.093 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 8.069658e-01 0.093 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 8.069658e-01 0.093 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 8.079248e-01 0.093 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 8.079248e-01 0.093 0 0
MET activates PTK2 signaling R-HSA-8874081 8.226070e-01 0.085 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.226070e-01 0.085 0 0
TRP channels R-HSA-3295583 8.226070e-01 0.085 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 8.233778e-01 0.084 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 8.233778e-01 0.084 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 8.233778e-01 0.084 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 8.233778e-01 0.084 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 8.233778e-01 0.084 0 0
Glycogen synthesis R-HSA-3322077 8.233778e-01 0.084 0 0
Protein hydroxylation R-HSA-9629569 8.233778e-01 0.084 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 8.250570e-01 0.084 0 0
Cardiogenesis R-HSA-9733709 8.250570e-01 0.084 0 0
Regulation of necroptotic cell death R-HSA-5675482 8.250570e-01 0.084 0 0
Prolactin receptor signaling R-HSA-1170546 8.314562e-01 0.080 0 0
Removal of the Flap Intermediate R-HSA-69166 8.314562e-01 0.080 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 8.314562e-01 0.080 0 0
NRIF signals cell death from the nucleus R-HSA-205043 8.314562e-01 0.080 0 0
Non-canonical inflammasome activation R-HSA-9686114 8.314562e-01 0.080 0 0
Malate-aspartate shuttle R-HSA-9856872 8.314562e-01 0.080 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.314562e-01 0.080 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 8.328798e-01 0.079 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 8.328798e-01 0.079 0 0
TRIF-mediated programmed cell death R-HSA-2562578 8.328798e-01 0.079 0 0
FGFR3b ligand binding and activation R-HSA-190371 8.328798e-01 0.079 0 0
DAG1 core M1 glycosylations R-HSA-8932506 8.328798e-01 0.079 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 8.328798e-01 0.079 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 8.328798e-01 0.079 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 8.328798e-01 0.079 0 0
VLDL clearance R-HSA-8964046 8.328798e-01 0.079 0 0
LDL remodeling R-HSA-8964041 8.328798e-01 0.079 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 8.328798e-01 0.079 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 8.328798e-01 0.079 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 8.328798e-01 0.079 0 0
Netrin mediated repulsion signals R-HSA-418886 8.328798e-01 0.079 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 8.328798e-01 0.079 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 8.401138e-01 0.076 0 0
Cristae formation R-HSA-8949613 8.401138e-01 0.076 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 8.401138e-01 0.076 0 0
Insulin processing R-HSA-264876 8.401138e-01 0.076 0 0
Resolution of D-Loop Structures R-HSA-5693537 8.409293e-01 0.075 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.409293e-01 0.075 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 8.428321e-01 0.074 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 8.428321e-01 0.074 0 0
Basigin interactions R-HSA-210991 8.428321e-01 0.074 0 0
Extension of Telomeres R-HSA-180786 8.443928e-01 0.073 0 0
Regulation of beta-cell development R-HSA-186712 8.443928e-01 0.073 0 0
Transmission across Chemical Synapses R-HSA-112315 8.446306e-01 0.073 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.531055e-01 0.069 0 0
Protein lipoylation R-HSA-9857492 8.531055e-01 0.069 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 8.531055e-01 0.069 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.531055e-01 0.069 0 0
FGFR3 ligand binding and activation R-HSA-190239 8.531055e-01 0.069 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 8.531055e-01 0.069 0 0
Signaling by Activin R-HSA-1502540 8.531055e-01 0.069 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 8.531055e-01 0.069 0 0
Formation of the anterior neural plate R-HSA-9823739 8.531055e-01 0.069 0 0
Signal amplification R-HSA-392518 8.555966e-01 0.068 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 8.558309e-01 0.068 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 8.561455e-01 0.067 0 0
phospho-PLA2 pathway R-HSA-111995 8.602650e-01 0.065 0 0
DAG1 core M2 glycosylations R-HSA-8932504 8.602650e-01 0.065 0 0
FGFR1b ligand binding and activation R-HSA-190370 8.602650e-01 0.065 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 8.602650e-01 0.065 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 8.602650e-01 0.065 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 8.602650e-01 0.065 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 8.602650e-01 0.065 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 8.602650e-01 0.065 0 0
Interleukin-9 signaling R-HSA-8985947 8.602650e-01 0.065 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 8.602650e-01 0.065 0 0
Sodium/Proton exchangers R-HSA-425986 8.602650e-01 0.065 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 8.602650e-01 0.065 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 8.604002e-01 0.065 0 0
Interferon gamma signaling R-HSA-877300 8.661510e-01 0.062 0 0
Platelet calcium homeostasis R-HSA-418360 8.707869e-01 0.060 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 8.721870e-01 0.059 0 0
Attachment and Entry R-HSA-9678110 8.721870e-01 0.059 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 8.721870e-01 0.059 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 8.721870e-01 0.059 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.721870e-01 0.059 0 0
Signaling by TGFB family members R-HSA-9006936 8.727042e-01 0.059 0 0
LDL clearance R-HSA-8964038 8.762196e-01 0.057 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 8.831640e-01 0.054 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 8.831640e-01 0.054 0 0
mRNA Editing R-HSA-75072 8.831640e-01 0.054 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 8.831640e-01 0.054 0 0
Regulation of signaling by NODAL R-HSA-1433617 8.831640e-01 0.054 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 8.831640e-01 0.054 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 8.831640e-01 0.054 0 0
Cellular response to mitochondrial stress R-HSA-9840373 8.831640e-01 0.054 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 8.831640e-01 0.054 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.841249e-01 0.053 0 0
Disease R-HSA-1643685 8.886418e-01 0.051 0 0
Phase 2 - plateau phase R-HSA-5576893 8.889609e-01 0.051 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 8.889609e-01 0.051 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 8.889609e-01 0.051 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 8.889609e-01 0.051 0 0
Passive transport by Aquaporins R-HSA-432047 8.889609e-01 0.051 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 8.889609e-01 0.051 0 0
Response to metal ions R-HSA-5660526 8.889609e-01 0.051 0 0
ABC-family proteins mediated transport R-HSA-382556 8.901004e-01 0.051 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 8.904265e-01 0.050 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 8.904265e-01 0.050 0 0
FCERI mediated MAPK activation R-HSA-2871796 8.908168e-01 0.050 0 0
Response of Mtb to phagocytosis R-HSA-9637690 8.918541e-01 0.050 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.962463e-01 0.048 0 0
Cargo concentration in the ER R-HSA-5694530 8.962463e-01 0.048 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 8.962463e-01 0.048 0 0
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594 9.023115e-01 0.045 0 0
Binding and entry of HIV virion R-HSA-173107 9.023115e-01 0.045 0 0
CASP4 inflammasome assembly R-HSA-9948001 9.023115e-01 0.045 0 0
Pexophagy R-HSA-9664873 9.023115e-01 0.045 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 9.023115e-01 0.045 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 9.031538e-01 0.044 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 9.031538e-01 0.044 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.031538e-01 0.044 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 9.034098e-01 0.044 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 9.036709e-01 0.044 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 9.036709e-01 0.044 0 0
Glycogen storage diseases R-HSA-3229121 9.036709e-01 0.044 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 9.036709e-01 0.044 0 0
Stimuli-sensing channels R-HSA-2672351 9.068283e-01 0.042 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.073302e-01 0.042 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 9.100394e-01 0.041 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.100394e-01 0.041 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.108114e-01 0.041 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.129573e-01 0.040 0 0
G protein gated Potassium channels R-HSA-1296059 9.145291e-01 0.039 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.145291e-01 0.039 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.145291e-01 0.039 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 9.145291e-01 0.039 0 0
Formation of the nephric duct R-HSA-9830364 9.145291e-01 0.039 0 0
Hyaluronan degradation R-HSA-2160916 9.145291e-01 0.039 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 9.165428e-01 0.038 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.165428e-01 0.038 0 0
PKA activation R-HSA-163615 9.165428e-01 0.038 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 9.165428e-01 0.038 0 0
PKA activation in glucagon signalling R-HSA-164378 9.165428e-01 0.038 0 0
Nephron development R-HSA-9831926 9.165428e-01 0.038 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 9.165428e-01 0.038 0 0
RAB geranylgeranylation R-HSA-8873719 9.177702e-01 0.037 0 0
DAG1 core M3 glycosylations R-HSA-8932505 9.183220e-01 0.037 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 9.183220e-01 0.037 0 0
LGI-ADAM interactions R-HSA-5682910 9.183220e-01 0.037 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 9.183220e-01 0.037 0 0
vRNA Synthesis R-HSA-192814 9.183220e-01 0.037 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 9.183220e-01 0.037 0 0
vRNP Assembly R-HSA-192905 9.183220e-01 0.037 0 0
Chylomicron assembly R-HSA-8963888 9.183220e-01 0.037 0 0
Transport of RCbl within the body R-HSA-9758890 9.183220e-01 0.037 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 9.183220e-01 0.037 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 9.183220e-01 0.037 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 9.183220e-01 0.037 0 0
Prostanoid ligand receptors R-HSA-391908 9.183220e-01 0.037 0 0
Dissolution of Fibrin Clot R-HSA-75205 9.183220e-01 0.037 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.191595e-01 0.037 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.208847e-01 0.036 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.216650e-01 0.035 0 0
Diseases of Immune System R-HSA-5260271 9.216650e-01 0.035 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 9.216650e-01 0.035 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 9.216650e-01 0.035 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.246742e-01 0.034 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 9.246742e-01 0.034 0 0
Iron uptake and transport R-HSA-917937 9.254653e-01 0.034 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 9.261612e-01 0.033 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 9.261612e-01 0.033 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 9.268161e-01 0.033 0 0
tRNA processing R-HSA-72306 9.294708e-01 0.032 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.304769e-01 0.031 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 9.317092e-01 0.031 0 0
Plasmalogen biosynthesis R-HSA-75896 9.317092e-01 0.031 0 0
NF-kB is activated and signals survival R-HSA-209560 9.317092e-01 0.031 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 9.317092e-01 0.031 0 0
Anchoring fibril formation R-HSA-2214320 9.317092e-01 0.031 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.320611e-01 0.031 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 9.337038e-01 0.030 0 0
Neddylation R-HSA-8951664 9.341415e-01 0.030 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.342535e-01 0.030 0 0
Signaling by NOTCH2 R-HSA-1980145 9.342535e-01 0.030 0 0
Hyaluronan metabolism R-HSA-2142845 9.342535e-01 0.030 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.342535e-01 0.030 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.342535e-01 0.030 0 0
Intra-Golgi traffic R-HSA-6811438 9.367955e-01 0.028 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.367955e-01 0.028 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.367955e-01 0.028 0 0
Creatine metabolism R-HSA-71288 9.375832e-01 0.028 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.375832e-01 0.028 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 9.375832e-01 0.028 0 0
PERK regulates gene expression R-HSA-381042 9.415330e-01 0.026 0 0
Telomere Extension By Telomerase R-HSA-171319 9.417251e-01 0.026 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.417251e-01 0.026 0 0
Cardiac conduction R-HSA-5576891 9.427247e-01 0.026 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 9.429029e-01 0.026 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 9.429029e-01 0.026 0 0
Beta oxidation of myristoyl-CoA to lauroyl-CoA R-HSA-77285 9.429029e-01 0.026 0 0
Beta oxidation of palmitoyl-CoA to myristoyl-CoA R-HSA-77305 9.429029e-01 0.026 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 9.429029e-01 0.026 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 9.429029e-01 0.026 0 0
IRAK1 recruits IKK complex R-HSA-937039 9.429029e-01 0.026 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 9.429029e-01 0.026 0 0
Maple Syrup Urine Disease R-HSA-9865114 9.429029e-01 0.026 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 9.429029e-01 0.026 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 9.429029e-01 0.026 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.433301e-01 0.025 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.461108e-01 0.024 0 0
G-protein activation R-HSA-202040 9.461108e-01 0.024 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 9.461108e-01 0.024 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 9.461108e-01 0.024 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.461108e-01 0.024 0 0
Translation R-HSA-72766 9.463459e-01 0.024 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.468259e-01 0.024 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.471355e-01 0.024 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 9.480697e-01 0.023 0 0
RNA Polymerase III Transcription R-HSA-74158 9.480697e-01 0.023 0 0
Triglyceride catabolism R-HSA-163560 9.480697e-01 0.023 0 0
Ca2+ pathway R-HSA-4086398 9.516970e-01 0.022 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 9.522623e-01 0.021 0 0
FGFR1c ligand binding and activation R-HSA-190373 9.522623e-01 0.021 0 0
Processing of SMDT1 R-HSA-8949664 9.522623e-01 0.021 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 9.522623e-01 0.021 0 0
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327 9.522623e-01 0.021 0 0
Diseases of nucleotide metabolism R-HSA-9735804 9.522623e-01 0.021 0 0
Acetylcholine binding and downstream events R-HSA-181431 9.522623e-01 0.021 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 9.522623e-01 0.021 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 9.522623e-01 0.021 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.529787e-01 0.021 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 9.535206e-01 0.021 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.535206e-01 0.021 0 0
Ribavirin ADME R-HSA-9755088 9.535206e-01 0.021 0 0
Metabolism of folate and pterines R-HSA-196757 9.539297e-01 0.020 0 0
Collagen chain trimerization R-HSA-8948216 9.539297e-01 0.020 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.540589e-01 0.020 0 0
Surfactant metabolism R-HSA-5683826 9.546000e-01 0.020 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 9.551348e-01 0.020 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.591746e-01 0.018 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.599497e-01 0.018 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 9.599497e-01 0.018 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.599497e-01 0.018 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 9.599497e-01 0.018 0 0
Ethanol oxidation R-HSA-71384 9.599497e-01 0.018 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.599497e-01 0.018 0 0
FGFR3c ligand binding and activation R-HSA-190372 9.600879e-01 0.018 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 9.600879e-01 0.018 0 0
Hydrolysis of LPC R-HSA-1483115 9.600879e-01 0.018 0 0
Beta oxidation of hexanoyl-CoA to butanoyl-CoA R-HSA-77350 9.600879e-01 0.018 0 0
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA R-HSA-77310 9.600879e-01 0.018 0 0
Beta oxidation of octanoyl-CoA to hexanoyl-CoA R-HSA-77348 9.600879e-01 0.018 0 0
Physiological factors R-HSA-5578768 9.600879e-01 0.018 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.600879e-01 0.018 0 0
Ciprofloxacin ADME R-HSA-9793528 9.600879e-01 0.018 0 0
Budding and maturation of HIV virion R-HSA-162588 9.607001e-01 0.017 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.638619e-01 0.016 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.646512e-01 0.016 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.655204e-01 0.015 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.655204e-01 0.015 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.656114e-01 0.015 0 0
Mitochondrial protein import R-HSA-1268020 9.660906e-01 0.015 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 9.666311e-01 0.015 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 9.666311e-01 0.015 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.666311e-01 0.015 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 9.666311e-01 0.015 0 0
Synthesis of 12-eicosatetraenoic acid derivatives R-HSA-2142712 9.666311e-01 0.015 0 0
Other semaphorin interactions R-HSA-416700 9.666311e-01 0.015 0 0
DNA Damage Reversal R-HSA-73942 9.666311e-01 0.015 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.676848e-01 0.014 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 9.694137e-01 0.013 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 9.694137e-01 0.013 0 0
Gluconeogenesis R-HSA-70263 9.712355e-01 0.013 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.717720e-01 0.012 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 9.721019e-01 0.012 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 9.721019e-01 0.012 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 9.721019e-01 0.012 0 0
Phase 4 - resting membrane potential R-HSA-5576886 9.721019e-01 0.012 0 0
Fructose catabolism R-HSA-70350 9.721019e-01 0.012 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 9.721019e-01 0.012 0 0
Virus Assembly and Release R-HSA-168268 9.721019e-01 0.012 0 0
Ion transport by P-type ATPases R-HSA-936837 9.724366e-01 0.012 0 0
Regulation of insulin secretion R-HSA-422356 9.729979e-01 0.012 0 0
SLC transporter disorders R-HSA-5619102 9.734604e-01 0.012 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.737483e-01 0.012 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 9.737483e-01 0.012 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.737483e-01 0.012 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.744013e-01 0.011 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.745088e-01 0.011 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.745088e-01 0.011 0 0
Translation of Structural Proteins R-HSA-9683701 9.750890e-01 0.011 0 0
Glycine degradation R-HSA-6783984 9.766760e-01 0.010 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 9.766760e-01 0.010 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 9.766760e-01 0.010 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.766760e-01 0.010 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 9.766760e-01 0.010 0 0
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids R-HSA-77288 9.766760e-01 0.010 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 9.766760e-01 0.010 0 0
Fibronectin matrix formation R-HSA-1566977 9.766760e-01 0.010 0 0
Synthesis of PG R-HSA-1483148 9.766760e-01 0.010 0 0
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA R-HSA-77346 9.766760e-01 0.010 0 0
Galactose catabolism R-HSA-70370 9.766760e-01 0.010 0 0
Coenzyme A biosynthesis R-HSA-196783 9.766760e-01 0.010 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.766760e-01 0.010 0 0
Platelet homeostasis R-HSA-418346 9.770076e-01 0.010 0 0
eNOS activation R-HSA-203615 9.770959e-01 0.010 0 0
Neuronal System R-HSA-112316 9.774232e-01 0.010 0 0
Activation of GABAB receptors R-HSA-991365 9.780372e-01 0.010 0 0
GABA B receptor activation R-HSA-977444 9.780372e-01 0.010 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.780372e-01 0.010 0 0
Urea cycle R-HSA-70635 9.781073e-01 0.010 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.781073e-01 0.010 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.781073e-01 0.010 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.792966e-01 0.009 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.796262e-01 0.009 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.799353e-01 0.009 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.800344e-01 0.009 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 9.805004e-01 0.009 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.805004e-01 0.009 0 0
Synthesis of 15-eicosatetraenoic acid derivatives R-HSA-2142770 9.805004e-01 0.009 0 0
Catecholamine biosynthesis R-HSA-209905 9.805004e-01 0.009 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.805004e-01 0.009 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.805004e-01 0.009 0 0
GDP-fucose biosynthesis R-HSA-6787639 9.805004e-01 0.009 0 0
tRNA Aminoacylation R-HSA-379724 9.817997e-01 0.008 0 0
Glycosphingolipid transport R-HSA-9845576 9.826109e-01 0.008 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 9.836979e-01 0.007 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 9.836979e-01 0.007 0 0
Aquaporin-mediated transport R-HSA-445717 9.837553e-01 0.007 0 0
Nucleotide biosynthesis R-HSA-8956320 9.840902e-01 0.007 0 0
Voltage gated Potassium channels R-HSA-1296072 9.848674e-01 0.007 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.848674e-01 0.007 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.850294e-01 0.007 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.850294e-01 0.007 0 0
COPII-mediated vesicle transport R-HSA-204005 9.855047e-01 0.006 0 0
Innate Immune System R-HSA-168249 9.855181e-01 0.006 1 0
RSV-host interactions R-HSA-9833110 9.855650e-01 0.006 0 0
PPARA activates gene expression R-HSA-1989781 9.856213e-01 0.006 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.861891e-01 0.006 0 0
Glucagon-type ligand receptors R-HSA-420092 9.861891e-01 0.006 0 0
Crosslinking of collagen fibrils R-HSA-2243919 9.863712e-01 0.006 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 9.863712e-01 0.006 0 0
Pyrimidine biosynthesis R-HSA-500753 9.863712e-01 0.006 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.863712e-01 0.006 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 9.863712e-01 0.006 0 0
Diseases of hemostasis R-HSA-9671793 9.863712e-01 0.006 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.863712e-01 0.006 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.863712e-01 0.006 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.863712e-01 0.006 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.867352e-01 0.006 0 0
Integration of energy metabolism R-HSA-163685 9.867443e-01 0.006 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.868473e-01 0.006 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.881703e-01 0.005 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.886063e-01 0.005 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.886063e-01 0.005 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.886063e-01 0.005 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.886063e-01 0.005 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.886063e-01 0.005 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.889630e-01 0.005 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.898733e-01 0.004 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 9.898733e-01 0.004 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 9.901553e-01 0.004 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.904749e-01 0.004 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.904749e-01 0.004 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.904749e-01 0.004 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.913848e-01 0.004 0 0
Maturation of spike protein R-HSA-9694548 9.913873e-01 0.004 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.920371e-01 0.003 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.920371e-01 0.003 0 0
Assembly Of The HIV Virion R-HSA-175474 9.920371e-01 0.003 0 0
Serine metabolism R-HSA-977347 9.920371e-01 0.003 0 0
Glutathione synthesis and recycling R-HSA-174403 9.920371e-01 0.003 0 0
Triglyceride metabolism R-HSA-8979227 9.923970e-01 0.003 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.925325e-01 0.003 0 0
Heme biosynthesis R-HSA-189451 9.925325e-01 0.003 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.925914e-01 0.003 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 9.933432e-01 0.003 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.933432e-01 0.003 0 0
Fructose metabolism R-HSA-5652084 9.933432e-01 0.003 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.933432e-01 0.003 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.933432e-01 0.003 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.933928e-01 0.003 0 0
Translation of Structural Proteins R-HSA-9694635 9.933928e-01 0.003 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.936681e-01 0.003 0 0
Heme degradation R-HSA-189483 9.936681e-01 0.003 0 0
Collagen degradation R-HSA-1442490 9.940914e-01 0.003 0 0
Interleukin-10 signaling R-HSA-6783783 9.941112e-01 0.003 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.944352e-01 0.002 0 0
Biosynthesis of maresins R-HSA-9018682 9.944352e-01 0.002 0 0
Formation of the ureteric bud R-HSA-9830674 9.944352e-01 0.002 0 0
Carnitine shuttle R-HSA-200425 9.944352e-01 0.002 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.945911e-01 0.002 0 0
RA biosynthesis pathway R-HSA-5365859 9.945911e-01 0.002 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.945911e-01 0.002 0 0
Protein localization R-HSA-9609507 9.946668e-01 0.002 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.947977e-01 0.002 0 0
Amine ligand-binding receptors R-HSA-375280 9.951517e-01 0.002 0 0
Ion channel transport R-HSA-983712 9.951759e-01 0.002 0 0
CYP2E1 reactions R-HSA-211999 9.953480e-01 0.002 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.953480e-01 0.002 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.953480e-01 0.002 0 0
Complex III assembly R-HSA-9865881 9.953480e-01 0.002 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.953816e-01 0.002 0 0
Paracetamol ADME R-HSA-9753281 9.960335e-01 0.002 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.960585e-01 0.002 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.961112e-01 0.002 0 0
Laminin interactions R-HSA-3000157 9.961112e-01 0.002 0 0
Formation of the cornified envelope R-HSA-6809371 9.963665e-01 0.002 0 0
Abacavir ADME R-HSA-2161522 9.967492e-01 0.001 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.967492e-01 0.001 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 9.967492e-01 0.001 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.967981e-01 0.001 0 0
Synthesis of PC R-HSA-1483191 9.968691e-01 0.001 0 0
Dectin-2 family R-HSA-5621480 9.969833e-01 0.001 0 0
Purine salvage R-HSA-74217 9.971328e-01 0.001 0 0
Elastic fibre formation R-HSA-1566948 9.971328e-01 0.001 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.972090e-01 0.001 0 0
Kidney development R-HSA-9830369 9.972707e-01 0.001 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.972826e-01 0.001 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.972826e-01 0.001 0 0
Triglyceride biosynthesis R-HSA-75109 9.972826e-01 0.001 0 0
Synthesis of PE R-HSA-1483213 9.972826e-01 0.001 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.972826e-01 0.001 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.972999e-01 0.001 0 0
Pentose phosphate pathway R-HSA-71336 9.975560e-01 0.001 0 0
RAS processing R-HSA-9648002 9.975560e-01 0.001 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.975560e-01 0.001 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.976056e-01 0.001 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.976673e-01 0.001 0 0
Insulin receptor recycling R-HSA-77387 9.977284e-01 0.001 0 0
Iron assimilation using enterobactin R-HSA-9638334 9.977284e-01 0.001 0 0
Pyrimidine salvage R-HSA-73614 9.977284e-01 0.001 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.979176e-01 0.001 0 0
Azathioprine ADME R-HSA-9748787 9.979880e-01 0.001 0 0
GABA receptor activation R-HSA-977443 9.980078e-01 0.001 0 0
Collagen formation R-HSA-1474290 9.980825e-01 0.001 0 0
Pyruvate metabolism R-HSA-70268 9.982014e-01 0.001 0 0
Neurotransmitter clearance R-HSA-112311 9.984128e-01 0.001 0 0
Phospholipid metabolism R-HSA-1483257 9.985733e-01 0.001 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.986533e-01 0.001 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.987147e-01 0.001 0 0
Neurotransmitter release cycle R-HSA-112310 9.987542e-01 0.001 0 0
DAG1 glycosylations R-HSA-8931838 9.988910e-01 0.000 0 0
HS-GAG degradation R-HSA-2024096 9.988910e-01 0.000 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.990698e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.990832e-01 0.000 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.991436e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.992421e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.992568e-01 0.000 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.993276e-01 0.000 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.993523e-01 0.000 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.993523e-01 0.000 0 0
Integrin cell surface interactions R-HSA-216083 9.993725e-01 0.000 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.994587e-01 0.000 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.994587e-01 0.000 0 0
HS-GAG biosynthesis R-HSA-2022928 9.995475e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.995817e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.995817e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.996162e-01 0.000 0 0
NCAM1 interactions R-HSA-419037 9.996218e-01 0.000 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.996218e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.996307e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.996307e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.996380e-01 0.000 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.996499e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.996544e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.997028e-01 0.000 0 0
The phototransduction cascade R-HSA-2514856 9.997028e-01 0.000 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.997377e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.997577e-01 0.000 0 0
Tryptophan catabolism R-HSA-71240 9.997792e-01 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 9.997995e-01 0.000 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.998154e-01 0.000 0 0
Potassium Channels R-HSA-1296071 9.998663e-01 0.000 0 0
Synthesis of PA R-HSA-1483166 9.998894e-01 0.000 0 0
Methylation R-HSA-156581 9.999100e-01 0.000 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.999100e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.999158e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.999181e-01 0.000 0 0
Peroxisomal protein import R-HSA-9033241 9.999205e-01 0.000 0 0
Sialic acid metabolism R-HSA-4085001 9.999205e-01 0.000 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.999247e-01 0.000 0 0
mitochondrial fatty acid beta-oxidation of saturated fatty acids R-HSA-77286 9.999247e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.999327e-01 0.000 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.999327e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999359e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.999401e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999480e-01 0.000 0 0
Metal ion SLC transporters R-HSA-425410 9.999561e-01 0.000 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.999561e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.999563e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.999591e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.999604e-01 0.000 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.999633e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.999654e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999721e-01 0.000 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.999744e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999748e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.999790e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999808e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999830e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.999893e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.999893e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.999896e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.999935e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.999939e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999943e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999943e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999944e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.999957e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999966e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.999967e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999967e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.999972e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999974e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999979e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.999986e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.999988e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.999992e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.999993e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999994e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999995e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.999995e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999999e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999999e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999999e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999999e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999999e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999999e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999999e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 1.000000e+00 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Visual phototransduction R-HSA-2187338 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
GPCR downstream signalling R-HSA-388396 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 -0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways