MAP2K4

TYR version of PSPA with Y as phospho-acceptor
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Y Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Log-Odds: Y Sites / Y Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
A5A3E0 Y940 Sugiyama POTEF A26C1B ALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPEA
O00165 S153 Sugiyama HAX1 HS1BP1 PDSHQPRIFGGVLESDARSEsPQPAPDWGsQRPFHRFDDVW
O15264 T180 GPS6|SIGNOR|EPSD MAPK13 PRKM13 SAPK4 EDCELKILDFGLARHADAEMtGyVVtRWYRAPEVILSWMHY
O15264 Y182 SIGNOR MAPK13 PRKM13 SAPK4 CELKILDFGLARHADAEMtGyVVtRWYRAPEVILSWMHYNQ
O43852 Y106 Sugiyama CALU GFVtVDELKDWIKFAQKRWIyEDVERQWKGHDLNEDGLVsW
O60361 Y136 Sugiyama NME2P1 SLRFKPEELVDYKSCAHDWVyE___________________
O60716 S252 Sugiyama CTNND1 KIAA0384 sRVtRIEERyRPsMEGyRAPsRQDVyGPQPQVRVGGssVDL
O60841 S182 Sugiyama EIF5B IF2 KIAA0741 DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O75347 Y75 Sugiyama TBCA EILQEsRMMIPDCQRRLEAAyLDLQRILENEKDLEEAEEyK
O94826 S91 Sugiyama TOMM70 KIAA0719 TOM70 TOMM70A RGDASGLKRNSERKtPEGRAsPAPGsGHPEGPGAHLDMNsL
P04406 T237 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P06733 S263 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GMDVAASEFFRsGKyDLDFKsPDDPsRyIsPDQLADLyKsF
P06744 S455 Sugiyama GPI ALMRGKSTEEARKELQAAGKsPEDLERLLPHKVFEGNRPTN
P07195 S320 Sugiyama LDHB GLtsVINQKLKDDEVAQLKKsADtLWDIQKDLKDL______
P07237 Y94 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB GSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFFRNGDTASPK
P07900 S53 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDsG
P07900 Y309 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA ELNKtKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHF
P08238 Y301 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB ELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHF
P08238 Y305 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB tKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEG
P10809 S70 Sugiyama HSPD1 HSP60 AVAVTMGPKGRtVIIEQsWGsPKVTKDGVtVAKsIDLKDKY
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P14625 Y401 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 VTFKSILFVPTSAPRGLFDEyGsKKSDYIKLYVRRVFITDD
P15336 T69 Sugiyama ATF2 CREB2 CREBP1 HEMtLKFGPARNDsVIVADQtPtPtRFLKNCEEVGLFNELA
P15336 T71 Sugiyama ATF2 CREB2 CREBP1 MtLKFGPARNDsVIVADQtPtPtRFLKNCEEVGLFNELAsP
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17544 T51 Sugiyama ATF7 ATFA HEMTLKFGPARtDsVIIADQtPtPtRFLKNCEEVGLFNELA
P17544 T53 Sugiyama ATF7 ATFA MTLKFGPARtDsVIIADQtPtPtRFLKNCEEVGLFNELASS
P17812 S575 Sugiyama CTPS1 CTPS LQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD____
P18615 Y170 Sugiyama NELFE RD RDBP GEEAEGPGAGDGPPRsFDWGyEERSGAHSsAsPPRsRSRDR
P18621 S5 Sugiyama RPL17 ________________MVRysLDPENPtKsCKSRGSNLRVH
P19793 Y249 SIGNOR|ELM|iPTMNet|EPSD|PSP RXRA NR2B1 DMPVERILEAELAVEPKTETyVEANMGLNPssPNDPVtNIC
P21333 Y2379 Sugiyama FLNA FLN FLN1 GAKGAIDAKVHsPsGALEECyVtEIDQDKYAVRFIPRENGV
P22234 S27 Sugiyama PAICS ADE2 AIRC PAIS LNIGKKLYEGKtKEVyELLDsPGKVLLQsKDQItAGNAARK
P22392 Y151 Sugiyama NME2 NM23B SLWFKPEELVDyKSCAHDWVyE___________________
P22626 S189 Sugiyama HNRNPA2B1 HNRPA2B1 IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P23434 Y139 Sugiyama GCSH EVTEINEALAENPGLVNKSCyEDGWLIKMtLsNPsELDELM
P24928 Y1909 Sugiyama POLR2A POLR2 sPtsPtysPtsPVytPtsPKysPtsPtysPtsPKysPtsPt
P25398 Y127 Sugiyama RPS12 sCVVVKDYGKESQAKDVIEEyFKCKK_______________
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P30086 T65 Sugiyama PEBP1 PBP PEBP QVKNRPtsIsWDGLDsGKLytLVLtDPDAPsRKDPKYREWH
P31943 Y266 Sugiyama HNRNPH1 HNRPH HNRPH1 yNGYNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGstFQst
P31948 Y354 Sugiyama STIP1 DVLKKCQQAEKILKEQERLAyINPDLALEEKNKGNECFQKG
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P35269 T389 Sugiyama GTF2F1 RAP74 PPKRERKPsGGSSRGNsRPGtPsAEGGstsstLRAAASKLE
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P42166 S159 Sugiyama TMPO LAP2 RKLYEKKLLKLREQGtEsRsstPLPtIsssAENtRQNGsND
P42167 S159 Sugiyama TMPO LAP2 RKLYEKKLLKLREQGTESRsstPLPTISsSAENTRQNGSND
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P45983 S284 PSP MAPK8 JNK1 PRKM8 SAPK1 SAPK1C PKyAGysFEKLFPDVLFPADsEHNKLKASQARDLLSKMLVI
P45983 T183 SIGNOR|EPSD|PSP MAPK8 JNK1 PRKM8 SAPK1 SAPK1C CTLKILDFGLARTAGtsFMMtPyVVtRyYRAPEVILGMGYK
P45983 Y185 SIGNOR|ELM|iPTMNet|EPSD|PSP MAPK8 JNK1 PRKM8 SAPK1 SAPK1C LKILDFGLARTAGtsFMMtPyVVtRyYRAPEVILGMGYKEN
P45984 T183 SIGNOR MAPK9 JNK2 PRKM9 SAPK1A CTLKILDFGLARTACTNFMMtPyVVtRYYRAPEVILGMGYK
P45984 Y185 SIGNOR|ELM|iPTMNet|EPSD|PSP MAPK9 JNK2 PRKM9 SAPK1A LKILDFGLARTACTNFMMtPyVVtRYYRAPEVILGMGYKEN
P45985 S257 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP MAP2K4 JNKK1 MEK4 MKK4 PRKMK4 SEK1 SERK1 SKK1 LDRSGNIKLCDFGIsGQLVDsIAKtRDAGCRPyMAPERIDP
P45985 S55 Sugiyama MAP2K4 JNKK1 MEK4 MKK4 PRKMK4 SEK1 SERK1 SKK1 SSMQGKRKALKLNFANPPFKstARFtLNPNPtGVQNPHIER
P45985 T261 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP MAP2K4 JNKK1 MEK4 MKK4 PRKMK4 SEK1 SERK1 SKK1 GNIKLCDFGIsGQLVDsIAKtRDAGCRPyMAPERIDPSASR
P45985 T56 Sugiyama MAP2K4 JNKK1 MEK4 MKK4 PRKMK4 SEK1 SERK1 SKK1 SMQGKRKALKLNFANPPFKstARFtLNPNPtGVQNPHIERL
P45985 T60 Sugiyama MAP2K4 JNKK1 MEK4 MKK4 PRKMK4 SEK1 SERK1 SKK1 KRKALKLNFANPPFKstARFtLNPNPtGVQNPHIERLRTHs
P45985 T66 Sugiyama MAP2K4 JNKK1 MEK4 MKK4 PRKMK4 SEK1 SERK1 SKK1 LNFANPPFKstARFtLNPNPtGVQNPHIERLRTHsIEsSGK
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P51991 Y360 Sugiyama HNRNPA3 HNRPA3 QSNYGPMKGGsFGGRssGsPyGGGyGsGGGsGGyGsRRF__
P52948 S623 Sugiyama NUP98 ADAR2 KNLNNsNLFsPVNRDsENLAsPsEyPENGERFsFLSKPVDE
P53778 Y185 ELM|iPTMNet|EPSD MAPK12 ERK6 SAPK3 CELKILDFGLARQADsEMtGyVVtRWYRAPEVILNWMRYTQ
P53779 T221 SIGNOR|EPSD MAPK10 JNK3 JNK3A PRKM10 SAPK1B CTLKILDFGLARTAGtsFMMtPyVVtRyYRAPEVILGMGYK
P53779 Y223 SIGNOR|ELM|iPTMNet|EPSD|PSP MAPK10 JNK3 JNK3A PRKM10 SAPK1B LKILDFGLARTAGtsFMMtPyVVtRyYRAPEVILGMGYKEN
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P55795 Y266 Sugiyama HNRNPH2 FTP3 HNRPH2 YGGYNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGssFQst
P60174 Y209 Sugiyama TPI1 TPI LRGWLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDG
P60709 S323 Sugiyama ACTB ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709 T324 Sugiyama ACTB tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P60709 Y240 Sugiyama ACTB ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P61604 Y100 Sugiyama HSPE1 KVVLDDKDyFLFRDGDILGKyVD__________________
P62263 T133 Sugiyama RPS14 PRO2640 QsALRALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL__
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62736 S325 Sugiyama ACTA2 ACTSA ACTVS GIG46 tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736 T326 Sugiyama ACTA2 ACTSA ACTVS GIG46 TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62736 Y242 Sugiyama ACTA2 ACTSA ACTVS GIG46 ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P63261 S323 Sugiyama ACTG1 ACTG ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261 T324 Sugiyama ACTG1 ACTG tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63261 Y240 Sugiyama ACTG1 ACTG ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P63267 S324 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267 T325 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P63267 Y241 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68032 S325 Sugiyama ACTC1 ACTC tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032 T326 Sugiyama ACTC1 ACTC TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68032 Y242 Sugiyama ACTC1 ACTC ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68133 S325 Sugiyama ACTA1 ACTA TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133 T326 Sugiyama ACTA1 ACTA TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68133 Y242 Sugiyama ACTA1 ACTA ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
Q00613 S363 Sugiyama HSF1 HSTF1 AsVTALtDARGHTDtEGRPPsPPPtstPEKCLsVACLDKNE
Q00839 Y260 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 GDKKRGVKRPREDHGRGyFEyIEENKysRAKsPQPPVEEED
Q06830 Y116 Sugiyama PRDX1 PAGA PAGB TDPX2 GLGPMNIPLVSDPKRtIAQDyGVLKADEGIsFRGLFIIDDK
Q07666 S20 Sugiyama KHDRBS1 SAM68 _MQRRDDPAARMsRssGRsGsMDPsGAHPsVRQtPsRQPPL
Q13158 S194 Sugiyama FADD MORT1 GIG3 ADLVQEVQQARDLQNRsGAMsPMsWNsDAsTSEAS______
Q13283 S232 Sugiyama G3BP1 G3BP EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q14004 S383 Sugiyama CDK13 CDC2L CDC2L5 CHED KIAA1791 sRRRSPSYSRHSSYERGGDVsPsPyssSsWRRsRsPysPVL
Q14568 S53 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 IINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDSG
Q15293 Y278 Sugiyama RCN1 RCN LNKDGKLDKDEIRHWILPQDyDHAQAEARHLVyESDKNKDE
Q15637 S82 Sugiyama SF1 ZFM1 ZNF162 TRKLRtGDLGIPPNPEDRsPsPEPIyNsEGKRLNTREFRTR
Q15759 T180 GPS6|EPSD MAPK11 PRKM11 SAPK2 SAPK2B EDCELRILDFGLARQADEEMtGyVAtRWYRAPEIMLNWMHY
Q15759 Y182 EPSD MAPK11 PRKM11 SAPK2 SAPK2B CELRILDFGLARQADEEMtGyVAtRWYRAPEIMLNWMHYNQ
Q16539 T180 GPS6|SIGNOR|EPSD|PSP MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A EDCELKILDFGLARHtDDEMtGyVAtRWYRAPEIMLNWMHY
Q16539 Y182 EPSD|PSP MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A CELKILDFGLARHtDDEMtGyVAtRWYRAPEIMLNWMHYNQ
Q562R1 Y241 Sugiyama ACTBL2 ALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPEA
Q58FF3 Y58 Sugiyama HSP90B2P GRP94B GRP94P1 TRAP1 VTFKSILFVPTFVPRGLFDEyGsKKSDYIKLYVRCVFITDD
Q6GYQ0 T1002 Sugiyama RALGAPA1 GARNL1 KIAA0884 TULIP1 TITGSESASPVHSPLGSRsQtPsPSTLNIDHMEQKDLQLDE
Q6S8J3 Y940 Sugiyama POTEE A26C1A POTE2 ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
Q6UN15 S492 Sugiyama FIP1L1 FIP1 RHE DRDRDRERERTRERERERDHsPtPsVFNsDEERyRYREYAE
Q6UN15 T494 Sugiyama FIP1L1 FIP1 RHE DRDRERERTRERERERDHsPtPsVFNsDEERyRYREYAERG
Q7L2J0 S216 Sugiyama MEPCE BCDIN3 NLNSLLDEEVSRtLNAEtPKssPLPAKGRDPVEILIPKDIt
Q7L2J0 T213 Sugiyama MEPCE BCDIN3 DPLNLNSLLDEEVSRtLNAEtPKssPLPAKGRDPVEILIPK
Q8IWX8 S815 Sugiyama CHERP DAN26 SCAF6 RSQSRSRSKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIP
Q8IWX8 S817 Sugiyama CHERP DAN26 SCAF6 QSRSRSKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIPDS
Q8IWX8 T819 Sugiyama CHERP DAN26 SCAF6 RSRSKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIPDSRL
Q8IZ21 S118 Sugiyama PHACTR4 PRO2963 PSDAMLKNGHTTPIGNARsssPVQVEEEPVRLAsLRKAIPE
Q8N684 S205 Sugiyama CPSF7 IPPRAHsRDssDsADGRAtPsENLVPSSARVDKPPSVLPYF
Q8N684 T203 Sugiyama CPSF7 GGIPPRAHsRDssDsADGRAtPsENLVPSSARVDKPPSVLP
Q8NFD5 S1744 Sugiyama ARID1B BAF250B DAN15 KIAA1235 OSA2 ALDTINILLYDDSTVATFNLsQLSGFLELLVEYFRKCLIDI
Q8TC07 S675 Sugiyama TBC1D15 TSAFQSNALPTLSASGARNDsPtQIPVssDVCRLtPA____
Q8WZ42 S20761 Sugiyama TTN GGSPIINYVVQKRDAERKSWsTVTTECsKTSFRVANLEEGK
Q8WZ42 S20768 Sugiyama TTN YVVQKRDAERKSWsTVTTECsKTSFRVANLEEGKSYFFRVF
Q96C19 S74 Sugiyama EFHD2 SWS1 ELSAKLLRRADLNQGIGEPQsPsRRVFNPytEFKEFSRKQI
Q96GM8 S420 Sugiyama TOE1 KNDLEMGIKAARPEIADRATsEVPGsQAsPNPVPGDGLHRA
Q96S44 T8 Sugiyama TP53RK C20orf64 PRPK _____________MAAARAttPADGEEPAPEAEALAAARER
Q9BTA9 S525 Sugiyama WAC KIAA1844 QGHEPVsPRSLQRsssQRsPsPGPNHtsNssNAsNATVVPQ
Q9BX95 S112 Sugiyama SGPP1 SPP1 GLAAELGPAsPRRAGALRRNsLtGEEGQLARVSNWPLYCLF
Q9BX95 T114 Sugiyama SGPP1 SPP1 AAELGPAsPRRAGALRRNsLtGEEGQLARVSNWPLYCLFCF
Q9BYX7 Y240 Sugiyama POTEKP ACTBL3 FKSG30 ALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPEA
Q9C0C2 S601 Sugiyama TNKS1BP1 KIAA1741 TAB182 LPLQQAEERyEsQEPLAGQEsPLPLATREAALPILEPVLGQ
Q9H4A3 S1261 Sugiyama WNK1 HSN2 KDP KIAA0344 PRKWNK1 GIPTSSLTQVVHSAGRRFIVsPVPEsRLRESKVFPSEITDT
Q9H7N4 S498 Sugiyama SCAF1 SFRS19 SRA1 GGLDLRRKILTQRRERyRQRsPsPAPAPAPAAAAGPPTRKK
Q9H7N4 S500 Sugiyama SCAF1 SFRS19 SRA1 LDLRRKILTQRRERyRQRsPsPAPAPAPAAAAGPPTRKKSR
Q9NWB6 S77 Sugiyama ARGLU1 RsRstNTAVSRRERDRERAssPPDRIDIFGRTVSKRSSLDE
Q9UKV3 S388 Sugiyama ACIN1 ACINUS KIAA0670 EEEEREIKssQGLKEKsKsPsPPRLtEDRKKAsLVALPEQt
Q9UPQ0 S217 Sugiyama LIMCH1 KIAA1102 GRDDsFDsLDsFGsRsRQtPsPDVVLRGssDGRGsDsEsDL
Q9UPQ0 T215 Sugiyama LIMCH1 KIAA1102 RHGRDDsFDsLDsFGsRsRQtPsPDVVLRGssDGRGsDsEs
Q9UQ35 S1102 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 EsPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEFs
Q9UQ35 S1103 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 sPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEFsA
Q9UQ35 S1112 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 TsPKGGRsRsssPVtELAsRsPIRQDRGEFsAsPMLKsGMs
Q9UQ35 S2132 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 SRMsCFsRPsMsPtPLDRCRsPGMLEPLGssRtPMsVLQQA
Q9UQ35 S876 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 tsPQANEQsVtPQRRsCFEssPDPELKsRtPsRHsCsGssP
Q9Y2U5 S164 Sugiyama MAP3K2 MAPKKK2 MEKK2 FGAERKKRLsIIGPTSRDRssPPPGYIPDELHQVARNGSFT
Q9Y2V2 S30 Sugiyama CARHSP1 QPPtHQAsVGLLDtPRsRERsPsPLRGNVVPsPLPtRRtRt
Q9Y2V2 S32 Sugiyama CARHSP1 PtHQAsVGLLDtPRsRERsPsPLRGNVVPsPLPtRRtRtFs
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
mRNA Splicing - Major Pathway R-HSA-72163 7.940883e-07 6.100 0 0
Signaling by LTK R-HSA-9842663 4.755439e-07 6.323 0 0
mRNA Splicing R-HSA-72172 1.333544e-06 5.875 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.008368e-05 4.996 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.376499e-05 4.624 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 3.055730e-05 4.515 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 8.147974e-05 4.089 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.084713e-04 3.965 0 0
Signaling by NTRKs R-HSA-166520 1.673910e-04 3.776 0 0
Apoptotic execution phase R-HSA-75153 1.574484e-04 3.803 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.020662e-04 3.695 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 2.675566e-04 3.573 0 0
Signal attenuation R-HSA-74749 2.551890e-04 3.593 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.429355e-04 3.615 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 3.867880e-04 3.413 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 3.337891e-04 3.477 0 0
DAP12 signaling R-HSA-2424491 3.709636e-04 3.431 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 3.709636e-04 3.431 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 4.662778e-04 3.331 0 0
Signaling by ERBB2 R-HSA-1227986 4.499719e-04 3.347 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 4.375541e-04 3.359 0 0
IGF1R signaling cascade R-HSA-2428924 5.815701e-04 3.235 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 6.185575e-04 3.209 0 0
RAF/MAP kinase cascade R-HSA-5673001 6.248702e-04 3.204 0 0
Erythropoietin activates RAS R-HSA-9027284 7.652607e-04 3.116 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 7.405706e-04 3.130 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 9.164217e-04 3.038 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.250222e-03 2.903 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.250222e-03 2.903 0 0
Regulation of signaling by CBL R-HSA-912631 1.491580e-03 2.826 0 0
DAP12 interactions R-HSA-2172127 1.442079e-03 2.841 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 1.653571e-03 2.782 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 1.788114e-03 2.748 0 0
IRS activation R-HSA-74713 1.970615e-03 2.705 0 0
NTRK2 activates RAC1 R-HSA-9032759 1.970615e-03 2.705 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 2.081600e-03 2.682 0 0
MAPK family signaling cascades R-HSA-5683057 2.229961e-03 2.652 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 2.368504e-03 2.626 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 2.558437e-03 2.592 0 0
Signal Transduction R-HSA-162582 3.418212e-03 2.466 0 0
SOS-mediated signalling R-HSA-112412 3.949830e-03 2.403 0 0
Signaling by Erythropoietin R-HSA-9006335 4.298794e-03 2.367 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 4.750709e-03 2.323 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 4.750709e-03 2.323 0 0
Transcription of the HIV genome R-HSA-167172 5.558066e-03 2.255 0 0
PI3K/AKT activation R-HSA-198203 6.556238e-03 2.183 0 0
Signaling by Leptin R-HSA-2586552 6.556238e-03 2.183 0 0
Apoptosis R-HSA-109581 6.689104e-03 2.175 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 7.558305e-03 2.122 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 7.222338e-03 2.141 0 0
RET signaling R-HSA-8853659 7.559008e-03 2.122 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 8.624880e-03 2.064 0 0
PIP3 activates AKT signaling R-HSA-1257604 9.049340e-03 2.043 0 0
Signaling by ALK R-HSA-201556 9.071890e-03 2.042 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.612625e-03 2.017 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 9.754716e-03 2.011 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 1.074951e-02 1.969 0 0
HIV Transcription Initiation R-HSA-167161 1.074951e-02 1.969 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 1.074951e-02 1.969 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.073603e-02 1.969 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 1.196103e-02 1.922 0 0
Cell-Cell communication R-HSA-1500931 1.294009e-02 1.888 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 1.324793e-02 1.878 0 0
DCC mediated attractive signaling R-HSA-418885 1.351157e-02 1.869 0 0
GPER1 signaling R-HSA-9634597 1.532103e-02 1.815 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 1.552984e-02 1.809 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.631032e-02 1.788 0 0
Signaling by Hippo R-HSA-2028269 1.779446e-02 1.750 0 0
TGFBR2 MSI Frameshift Mutants in Cancer R-HSA-3642279 1.821488e-02 1.740 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.933360e-02 1.714 0 0
HDACs deacetylate histones R-HSA-3214815 2.083209e-02 1.681 0 0
Potential therapeutics for SARS R-HSA-9679191 2.007815e-02 1.697 0 0
Programmed Cell Death R-HSA-5357801 1.832644e-02 1.737 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.931031e-02 1.714 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 2.257241e-02 1.646 0 0
Nephrin family interactions R-HSA-373753 2.257241e-02 1.646 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 2.426989e-02 1.615 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 2.426989e-02 1.615 0 0
Regulation of TP53 Activity R-HSA-5633007 2.495799e-02 1.603 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 2.601800e-02 1.585 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 2.601800e-02 1.585 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 2.781568e-02 1.556 0 0
Insulin receptor signalling cascade R-HSA-74751 2.931387e-02 1.533 0 0
Metabolism of RNA R-HSA-8953854 2.670083e-02 1.573 0 0
Mitochondrial calcium ion transport R-HSA-8949215 2.601800e-02 1.585 0 0
Growth hormone receptor signaling R-HSA-982772 2.966188e-02 1.528 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 3.610017e-02 1.442 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 3.610017e-02 1.442 0 0
NTF4 activates NTRK2 (TRKB) signaling R-HSA-9026357 3.610017e-02 1.442 0 0
BDNF activates NTRK2 (TRKB) signaling R-HSA-9024909 3.610017e-02 1.442 0 0
NTF3 activates NTRK2 (TRKB) signaling R-HSA-9025046 3.610017e-02 1.442 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 3.610017e-02 1.442 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 3.610017e-02 1.442 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 3.610017e-02 1.442 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 3.610017e-02 1.442 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 3.610017e-02 1.442 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 3.610017e-02 1.442 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 3.610017e-02 1.442 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.610017e-02 1.442 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 3.610017e-02 1.442 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 3.610017e-02 1.442 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 3.610017e-02 1.442 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 3.610017e-02 1.442 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 3.155559e-02 1.501 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 3.155559e-02 1.501 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 3.035307e-02 1.518 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 3.349578e-02 1.475 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 3.191596e-02 1.496 0 0
Interleukin-7 signaling R-HSA-1266695 3.349578e-02 1.475 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 3.751168e-02 1.426 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 3.751168e-02 1.426 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 3.751168e-02 1.426 0 0
HIV elongation arrest and recovery R-HSA-167287 3.958542e-02 1.402 0 0
Pausing and recovery of HIV elongation R-HSA-167290 3.958542e-02 1.402 0 0
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336 4.492108e-02 1.348 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 4.170175e-02 1.380 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 4.385973e-02 1.358 0 0
Integrin signaling R-HSA-354192 5.057434e-02 1.296 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 4.852832e-02 1.314 0 0
Developmental Cell Lineages R-HSA-9734767 4.754840e-02 1.323 0 0
Signaling by VEGF R-HSA-194138 4.104781e-02 1.387 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 4.170175e-02 1.380 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 4.385973e-02 1.358 0 0
Signaling by FGFR2 R-HSA-5654738 4.821909e-02 1.317 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 5.366181e-02 1.270 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 5.366181e-02 1.270 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 5.366181e-02 1.270 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 5.366181e-02 1.270 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 6.232308e-02 1.205 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 6.232308e-02 1.205 0 0
NGF-independant TRKA activation R-HSA-187024 7.090561e-02 1.149 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 7.090561e-02 1.149 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 7.090561e-02 1.149 0 0
Erythropoietin activates STAT5 R-HSA-9027283 7.941011e-02 1.100 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 8.783729e-02 1.056 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 8.783729e-02 1.056 0 0
Type I hemidesmosome assembly R-HSA-446107 9.618783e-02 1.017 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 9.618783e-02 1.017 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 9.618783e-02 1.017 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 9.618783e-02 1.017 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 5.524232e-02 1.258 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 7.009013e-02 1.154 0 0
HIV Transcription Elongation R-HSA-167169 7.009013e-02 1.154 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 7.009013e-02 1.154 0 0
Signaling by RAF1 mutants R-HSA-9656223 7.529883e-02 1.123 0 0
MAP2K and MAPK activation R-HSA-5674135 7.529883e-02 1.123 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 6.753243e-02 1.170 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 5.524232e-02 1.258 0 0
Regulation of gap junction activity R-HSA-191650 5.366181e-02 1.270 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 7.666240e-02 1.115 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 7.941011e-02 1.100 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 8.882918e-02 1.051 0 0
Signaling downstream of RAS mutants R-HSA-9649948 8.882918e-02 1.051 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 8.882918e-02 1.051 0 0
Oncogenic MAPK signaling R-HSA-6802957 5.509778e-02 1.259 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 6.251426e-02 1.204 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 8.606795e-02 1.065 0 0
Late Phase of HIV Life Cycle R-HSA-162599 6.106719e-02 1.214 0 0
Signaling by RAS mutants R-HSA-6802949 8.882918e-02 1.051 0 0
Signaling by Insulin receptor R-HSA-74752 6.858344e-02 1.164 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 5.366181e-02 1.270 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 7.090561e-02 1.149 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 8.783729e-02 1.056 0 0
Activation of TRKA receptors R-HSA-187015 8.783729e-02 1.056 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 8.783729e-02 1.056 0 0
Unwinding of DNA R-HSA-176974 1.044624e-01 0.981 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 8.783729e-02 1.056 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 8.783729e-02 1.056 0 0
HIV Life Cycle R-HSA-162587 7.891653e-02 1.103 0 0
Parasite infection R-HSA-9664407 5.778534e-02 1.238 0 0
Leishmania phagocytosis R-HSA-9664417 5.778534e-02 1.238 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 5.778534e-02 1.238 0 0
VLDL clearance R-HSA-8964046 8.783729e-02 1.056 0 0
GPVI-mediated activation cascade R-HSA-114604 6.005542e-02 1.221 0 0
HIV Infection R-HSA-162906 7.876630e-02 1.104 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 5.366181e-02 1.270 0 0
Reelin signalling pathway R-HSA-8866376 6.232308e-02 1.205 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 9.618783e-02 1.017 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.044624e-01 0.981 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 5.257125e-02 1.279 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 8.019012e-02 1.096 0 0
Netrin-1 signaling R-HSA-373752 8.333357e-02 1.079 0 0
Signalling to ERKs R-HSA-187687 5.763116e-02 1.239 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 7.009013e-02 1.154 0 0
Diseases of Immune System R-HSA-5260271 7.009013e-02 1.154 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 1.033693e-01 0.986 0 0
Glycogen metabolism R-HSA-8982491 7.009013e-02 1.154 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 7.090561e-02 1.149 0 0
Nef and signal transduction R-HSA-164944 7.941011e-02 1.100 0 0
Degradation of CDH1 R-HSA-9766229 9.726692e-02 1.012 0 0
Cell junction organization R-HSA-446728 5.815418e-02 1.235 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 5.763116e-02 1.239 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 5.763116e-02 1.239 0 0
PI3K Cascade R-HSA-109704 1.001285e-01 0.999 0 0
Epigenetic regulation of gene expression R-HSA-212165 9.784795e-02 1.009 0 0
Signaling by FGFR R-HSA-190236 8.000653e-02 1.097 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 5.797377e-02 1.237 0 0
Disease R-HSA-1643685 9.120369e-02 1.040 1 0
Ub-specific processing proteases R-HSA-5689880 1.019282e-01 0.992 0 0
Signaling by FGFR4 R-HSA-5654743 8.062677e-02 1.094 0 0
Signaling by FGFR3 R-HSA-5654741 8.606795e-02 1.065 0 0
Viral Infection Pathways R-HSA-9824446 6.331380e-02 1.199 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 9.764438e-02 1.010 0 0
Chromatin organization R-HSA-4839726 1.034593e-01 0.985 0 0
Signaling by ALK in cancer R-HSA-9700206 9.764438e-02 1.010 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 8.073145e-02 1.093 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 5.763116e-02 1.239 0 0
ESR-mediated signaling R-HSA-8939211 8.955380e-02 1.048 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 8.513988e-02 1.070 0 0
Signaling by Interleukins R-HSA-449147 7.549785e-02 1.122 1 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 8.333357e-02 1.079 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.048198e-01 0.980 0 0
Cell-cell junction organization R-HSA-421270 1.058763e-01 0.975 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.059213e-01 0.975 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 1.126618e-01 0.948 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 1.368152e-01 0.864 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 1.368152e-01 0.864 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.368152e-01 0.864 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.447203e-01 0.839 0 0
CRMPs in Sema3A signaling R-HSA-399956 1.525535e-01 0.817 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 1.525535e-01 0.817 0 0
SHC1 events in EGFR signaling R-HSA-180336 1.603154e-01 0.795 0 0
G beta:gamma signalling through BTK R-HSA-8964315 1.603154e-01 0.795 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 1.603154e-01 0.795 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.680067e-01 0.775 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 1.756281e-01 0.755 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 1.756281e-01 0.755 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 1.831801e-01 0.737 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.831801e-01 0.737 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 1.980785e-01 0.703 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.088512e-01 0.963 0 0
Nuclear Receptor transcription pathway R-HSA-383280 1.875629e-01 0.727 0 0
Ephrin signaling R-HSA-3928664 1.906633e-01 0.720 0 0
CD28 dependent Vav1 pathway R-HSA-389359 1.447203e-01 0.839 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.603154e-01 0.795 0 0
Regulation of CDH11 function R-HSA-9762292 1.126618e-01 0.948 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.207866e-01 0.918 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 1.680067e-01 0.775 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 1.330101e-01 0.876 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.603154e-01 0.795 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 1.906633e-01 0.720 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 1.980785e-01 0.703 0 0
Signalling to RAS R-HSA-167044 2.127070e-01 0.672 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.582384e-01 0.801 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.906633e-01 0.720 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 1.167027e-01 0.933 0 0
IRS-mediated signalling R-HSA-112399 1.207787e-01 0.918 0 0
Regulation of CDH1 Function R-HSA-9764561 1.207787e-01 0.918 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.054262e-01 0.687 0 0
Semaphorin interactions R-HSA-373755 1.392281e-01 0.856 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.126618e-01 0.948 0 0
MET activates RAS signaling R-HSA-8851805 1.368152e-01 0.864 0 0
Co-inhibition by CTLA4 R-HSA-389513 2.054262e-01 0.687 0 0
NCAM signaling for neurite out-growth R-HSA-375165 1.361111e-01 0.866 0 0
Regulation of KIT signaling R-HSA-1433559 1.525535e-01 0.817 0 0
Interleukin-15 signaling R-HSA-8983432 1.368152e-01 0.864 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 1.489998e-01 0.827 1 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 1.288375e-01 0.890 0 0
Formation of the cornified envelope R-HSA-6809371 1.349429e-01 0.870 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 1.785708e-01 0.748 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 1.525535e-01 0.817 0 0
Amyloid fiber formation R-HSA-977225 1.975031e-01 0.704 0 0
G alpha (12/13) signalling events R-HSA-416482 1.875629e-01 0.727 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.288375e-01 0.890 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.368152e-01 0.864 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 1.368152e-01 0.864 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 1.447203e-01 0.839 0 0
Protein lipoylation R-HSA-9857492 1.603154e-01 0.795 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.356137e-01 0.868 0 0
Axon guidance R-HSA-422475 1.516507e-01 0.819 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.831801e-01 0.737 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.831801e-01 0.737 0 0
Kinesins R-HSA-983189 1.299259e-01 0.886 0 0
Nervous system development R-HSA-9675108 1.922223e-01 0.716 0 0
Pervasive developmental disorders R-HSA-9005895 1.368152e-01 0.864 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 1.368152e-01 0.864 0 0
Disorders of Nervous System Development R-HSA-9697154 1.368152e-01 0.864 0 0
Signaling by ERBB4 R-HSA-1236394 1.744275e-01 0.758 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.875629e-01 0.727 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 2.127070e-01 0.672 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 2.127070e-01 0.672 0 0
Disorders of Developmental Biology R-HSA-9675151 1.756281e-01 0.755 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.906633e-01 0.720 0 0
Adherens junctions interactions R-HSA-418990 1.769865e-01 0.752 0 0
Frs2-mediated activation R-HSA-170968 1.447203e-01 0.839 0 0
Protein localization R-HSA-9609507 2.087461e-01 0.680 0 0
PECAM1 interactions R-HSA-210990 1.207866e-01 0.918 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 2.054262e-01 0.687 0 0
Cytoprotection by HMOX1 R-HSA-9707564 2.041658e-01 0.690 0 0
Signaling by FGFR in disease R-HSA-1226099 1.744275e-01 0.758 0 0
Signaling by MET R-HSA-6806834 1.941821e-01 0.712 0 0
Interleukin-2 signaling R-HSA-9020558 1.207866e-01 0.918 0 0
Prolonged ERK activation events R-HSA-169893 1.680067e-01 0.775 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.447203e-01 0.839 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 2.054262e-01 0.687 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 1.238096e-01 0.907 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 1.842655e-01 0.735 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.111144e-01 0.675 0 0
Signaling by FGFR1 R-HSA-5654736 1.177668e-01 0.929 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 1.368152e-01 0.864 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.392281e-01 0.856 0 0
Signaling by PTK6 R-HSA-8848021 1.392281e-01 0.856 0 0
Tie2 Signaling R-HSA-210993 1.906633e-01 0.720 0 0
Chromatin modifying enzymes R-HSA-3247509 2.066014e-01 0.685 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.426622e-01 0.846 0 0
Deubiquitination R-HSA-5688426 1.107935e-01 0.955 0 0
DNA Damage Reversal R-HSA-73942 1.603154e-01 0.795 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 1.679184e-01 0.775 0 0
Cytokine Signaling in Immune system R-HSA-1280215 2.078751e-01 0.682 1 0
PKR-mediated signaling R-HSA-9833482 1.941821e-01 0.712 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 2.111144e-01 0.675 0 0
MHC class II antigen presentation R-HSA-2132295 1.328691e-01 0.877 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.455083e-01 0.837 0 0
XBP1(S) activates chaperone genes R-HSA-381038 2.175631e-01 0.662 0 0
Interleukin-12 signaling R-HSA-9020591 1.809768e-01 0.742 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 2.199216e-01 0.658 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.199216e-01 0.658 0 0
Interleukin-12 family signaling R-HSA-447115 2.209252e-01 0.656 0 0
Selective autophagy R-HSA-9663891 2.242916e-01 0.649 0 0
Infectious disease R-HSA-5663205 2.255095e-01 0.647 1 0
FGFR2 alternative splicing R-HSA-6803529 2.270704e-01 0.644 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 2.270704e-01 0.644 0 0
Notch-HLH transcription pathway R-HSA-350054 2.270704e-01 0.644 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 2.270704e-01 0.644 0 0
Signaling by KIT in disease R-HSA-9669938 2.270704e-01 0.644 0 0
mTORC1-mediated signalling R-HSA-166208 2.270704e-01 0.644 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 2.270704e-01 0.644 0 0
LDL clearance R-HSA-8964038 2.270704e-01 0.644 0 0
ER-Phagosome pathway R-HSA-1236974 2.276621e-01 0.643 0 0
Interleukin receptor SHC signaling R-HSA-912526 2.341542e-01 0.630 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 2.341542e-01 0.630 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 2.341542e-01 0.630 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.341542e-01 0.630 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 2.341542e-01 0.630 0 0
HCMV Infection R-HSA-9609646 2.375386e-01 0.624 0 0
IRE1alpha activates chaperones R-HSA-381070 2.377939e-01 0.624 0 0
Deadenylation of mRNA R-HSA-429947 2.411735e-01 0.618 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 2.411735e-01 0.618 0 0
Tight junction interactions R-HSA-420029 2.481290e-01 0.605 0 0
Sema4D in semaphorin signaling R-HSA-400685 2.481290e-01 0.605 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 2.481290e-01 0.605 0 0
HDMs demethylate histones R-HSA-3214842 2.481290e-01 0.605 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 2.481290e-01 0.605 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 2.481290e-01 0.605 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 2.481290e-01 0.605 0 0
G alpha (s) signalling events R-HSA-418555 2.546297e-01 0.594 0 0
Signaling by EGFR in Cancer R-HSA-1643713 2.550210e-01 0.593 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 2.581199e-01 0.588 0 0
COPI-mediated anterograde transport R-HSA-6807878 2.581199e-01 0.588 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.595488e-01 0.586 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.595488e-01 0.586 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.615120e-01 0.583 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 2.618504e-01 0.582 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 2.618504e-01 0.582 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 2.618504e-01 0.582 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 2.686175e-01 0.571 0 0
Formation of the Early Elongation Complex R-HSA-113418 2.686175e-01 0.571 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 2.686175e-01 0.571 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 2.686175e-01 0.571 0 0
Cellular response to chemical stress R-HSA-9711123 2.735432e-01 0.563 0 0
Late endosomal microautophagy R-HSA-9615710 2.753230e-01 0.560 0 0
mRNA Capping R-HSA-72086 2.753230e-01 0.560 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.753230e-01 0.560 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 2.753230e-01 0.560 0 0
Activation of the pre-replicative complex R-HSA-68962 2.819675e-01 0.550 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 2.819675e-01 0.550 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 2.819675e-01 0.550 0 0
Activation of BH3-only proteins R-HSA-114452 2.819675e-01 0.550 0 0
Gene expression (Transcription) R-HSA-74160 2.830875e-01 0.548 0 0
Downstream signal transduction R-HSA-186763 2.885514e-01 0.540 0 0
Activation of HOX genes during differentiation R-HSA-5619507 2.886407e-01 0.540 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 2.886407e-01 0.540 0 0
DNA strand elongation R-HSA-69190 2.950754e-01 0.530 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.950754e-01 0.530 0 0
Parasitic Infection Pathways R-HSA-9824443 3.001073e-01 0.523 0 0
Leishmania infection R-HSA-9658195 3.001073e-01 0.523 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 3.015399e-01 0.521 0 0
Activation of ATR in response to replication stress R-HSA-176187 3.015399e-01 0.521 0 0
G-protein beta:gamma signalling R-HSA-397795 3.015399e-01 0.521 0 0
FGFR1 mutant receptor activation R-HSA-1839124 3.015399e-01 0.521 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 3.015399e-01 0.521 0 0
Antigen processing-Cross presentation R-HSA-1236975 3.021721e-01 0.520 0 0
Striated Muscle Contraction R-HSA-390522 3.079456e-01 0.512 0 0
RAF activation R-HSA-5673000 3.142929e-01 0.503 0 0
Mitophagy R-HSA-5205647 3.142929e-01 0.503 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 3.142929e-01 0.503 0 0
FCERI mediated MAPK activation R-HSA-2871796 3.156602e-01 0.501 1 1
HCMV Early Events R-HSA-9609690 3.167879e-01 0.499 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 3.167879e-01 0.499 0 0
Hemostasis R-HSA-109582 3.220003e-01 0.492 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 3.268146e-01 0.486 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 3.268146e-01 0.486 0 0
FGFR2 mutant receptor activation R-HSA-1839126 3.268146e-01 0.486 0 0
RNA Polymerase III Transcription R-HSA-74158 3.268146e-01 0.486 0 0
Regulation of TP53 Degradation R-HSA-6804757 3.268146e-01 0.486 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 3.290906e-01 0.483 0 0
NCAM1 interactions R-HSA-419037 3.329900e-01 0.478 0 0
MET promotes cell motility R-HSA-8875878 3.391091e-01 0.470 0 0
Keratinization R-HSA-6805567 3.443333e-01 0.463 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 3.451725e-01 0.462 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 3.451725e-01 0.462 0 0
RAS processing R-HSA-9648002 3.451725e-01 0.462 0 0
Plasma lipoprotein clearance R-HSA-8964043 3.451725e-01 0.462 0 0
Pentose phosphate pathway R-HSA-71336 3.451725e-01 0.462 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 3.451725e-01 0.462 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 3.457773e-01 0.461 1 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 3.457773e-01 0.461 1 0
Generation of second messenger molecules R-HSA-202433 3.511806e-01 0.454 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 3.511806e-01 0.454 0 0
Interleukin-2 family signaling R-HSA-451927 3.511806e-01 0.454 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 3.511806e-01 0.454 0 0
Aggrephagy R-HSA-9646399 3.511806e-01 0.454 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 3.524156e-01 0.453 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 3.557261e-01 0.449 1 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 3.557261e-01 0.449 1 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 3.571339e-01 0.447 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 3.571339e-01 0.447 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 3.571339e-01 0.447 0 0
FLT3 Signaling R-HSA-9607240 3.571339e-01 0.447 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.630330e-01 0.440 0 0
Negative regulation of MAPK pathway R-HSA-5675221 3.630330e-01 0.440 0 0
MTOR signalling R-HSA-165159 3.688783e-01 0.433 0 0
Signaling by SCF-KIT R-HSA-1433557 3.746704e-01 0.426 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 3.746704e-01 0.426 0 0
Platelet degranulation R-HSA-114608 3.754594e-01 0.425 0 0
EPHB-mediated forward signaling R-HSA-3928662 3.804096e-01 0.420 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 3.917316e-01 0.407 0 0
Signaling by TGFBR3 R-HSA-9839373 3.917316e-01 0.407 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 3.917316e-01 0.407 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 3.973153e-01 0.401 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 3.973153e-01 0.401 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 3.981667e-01 0.400 0 0
Co-stimulation by CD28 R-HSA-389356 4.028481e-01 0.395 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 4.028481e-01 0.395 0 0
Gap junction trafficking and regulation R-HSA-157858 4.083304e-01 0.389 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 4.083304e-01 0.389 0 0
Estrogen-dependent gene expression R-HSA-9018519 4.109726e-01 0.386 0 0
Signaling by FGFR2 in disease R-HSA-5655253 4.137627e-01 0.383 0 0
Membrane Trafficking R-HSA-199991 4.180499e-01 0.379 0 0
Complex IV assembly R-HSA-9864848 4.191455e-01 0.378 0 0
The phototransduction cascade R-HSA-2514856 4.191455e-01 0.378 0 0
Unfolded Protein Response (UPR) R-HSA-381119 4.204899e-01 0.376 0 0
mRNA 3'-end processing R-HSA-72187 4.244792e-01 0.372 0 0
Orc1 removal from chromatin R-HSA-68949 4.244792e-01 0.372 0 0
Macroautophagy R-HSA-1632852 4.267916e-01 0.370 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 4.297643e-01 0.367 0 0
Translation initiation complex formation R-HSA-72649 4.350011e-01 0.362 0 0
SARS-CoV Infections R-HSA-9679506 4.363904e-01 0.360 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 4.401902e-01 0.356 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 4.453319e-01 0.351 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 4.453319e-01 0.351 0 0
NRAGE signals death through JNK R-HSA-193648 4.453319e-01 0.351 0 0
Signaling by EGFR R-HSA-177929 4.453319e-01 0.351 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 4.453319e-01 0.351 0 0
TNF signaling R-HSA-75893 4.453319e-01 0.351 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 4.453319e-01 0.351 0 0
ER to Golgi Anterograde Transport R-HSA-199977 4.485626e-01 0.348 0 0
Nuclear Envelope Breakdown R-HSA-2980766 4.504267e-01 0.346 0 0
Dectin-2 family R-HSA-5621480 4.504267e-01 0.346 0 0
Synthesis of PA R-HSA-1483166 4.504267e-01 0.346 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 4.516353e-01 0.345 1 0
Dual incision in TC-NER R-HSA-6782135 4.554751e-01 0.342 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 4.554751e-01 0.342 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 4.604773e-01 0.337 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 4.604773e-01 0.337 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 4.607954e-01 0.336 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 4.638291e-01 0.334 0 0
Regulation of PTEN gene transcription R-HSA-8943724 4.654340e-01 0.332 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 4.654340e-01 0.332 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 4.654340e-01 0.332 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 4.654340e-01 0.332 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 4.654340e-01 0.332 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 4.654340e-01 0.332 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 4.654340e-01 0.332 0 0
Death Receptor Signaling R-HSA-73887 4.698667e-01 0.328 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 4.703454e-01 0.328 0 0
Viral Messenger RNA Synthesis R-HSA-168325 4.703454e-01 0.328 0 0
Heme signaling R-HSA-9707616 4.752119e-01 0.323 0 0
Mitochondrial protein import R-HSA-1268020 4.752119e-01 0.323 0 0
Signaling by PDGF R-HSA-186797 4.752119e-01 0.323 0 0
Autophagy R-HSA-9612973 4.758639e-01 0.323 0 0
HCMV Late Events R-HSA-9610379 4.788472e-01 0.320 0 0
Complex I biogenesis R-HSA-6799198 4.800341e-01 0.319 0 0
Generic Transcription Pathway R-HSA-212436 4.803469e-01 0.318 0 0
Signaling by TGFB family members R-HSA-9006936 4.877353e-01 0.312 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 5.034926e-01 0.298 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 5.034926e-01 0.298 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 5.125789e-01 0.290 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 5.125789e-01 0.290 0 0
RNA Polymerase II Transcription R-HSA-73857 5.138375e-01 0.289 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 5.170600e-01 0.286 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 5.170600e-01 0.286 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 5.170600e-01 0.286 0 0
Adaptive Immune System R-HSA-1280218 5.211854e-01 0.283 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 5.215001e-01 0.283 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 5.215001e-01 0.283 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 5.258996e-01 0.279 0 0
Switching of origins to a post-replicative state R-HSA-69052 5.258996e-01 0.279 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 5.258996e-01 0.279 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 5.345786e-01 0.272 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 5.345786e-01 0.272 0 0
ISG15 antiviral mechanism R-HSA-1169408 5.345786e-01 0.272 0 0
UCH proteinases R-HSA-5689603 5.388587e-01 0.269 0 0
Signaling by NOTCH1 R-HSA-1980143 5.388587e-01 0.269 0 0
Respiratory electron transport R-HSA-611105 5.417854e-01 0.266 0 0
Developmental Biology R-HSA-1266738 5.462051e-01 0.263 0 0
Integrin cell surface interactions R-HSA-216083 5.473019e-01 0.262 0 0
Sensory processing of sound R-HSA-9659379 5.514658e-01 0.258 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 5.555917e-01 0.255 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 5.555917e-01 0.255 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 5.555917e-01 0.255 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 5.596798e-01 0.252 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 5.637306e-01 0.249 0 0
Toll-like Receptor Cascades R-HSA-168898 5.764470e-01 0.239 1 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 5.790333e-01 0.237 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 5.834359e-01 0.234 0 0
Post NMDA receptor activation events R-HSA-438064 5.872696e-01 0.231 0 0
Pyruvate metabolism R-HSA-70268 5.872696e-01 0.231 0 0
Immune System R-HSA-168256 5.915377e-01 0.228 1 0
Transcriptional Regulation by MECP2 R-HSA-8986944 6.022569e-01 0.220 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 6.042648e-01 0.219 0 0
EPH-Ephrin signaling R-HSA-2682334 6.095466e-01 0.215 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 6.095466e-01 0.215 0 0
Assembly of the pre-replicative complex R-HSA-68867 6.131416e-01 0.212 0 0
FCGR activation R-HSA-2029481 6.131416e-01 0.212 0 0
Collagen formation R-HSA-1474290 6.167036e-01 0.210 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 6.202331e-01 0.207 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 6.271955e-01 0.203 0 0
Telomere Maintenance R-HSA-157579 6.306290e-01 0.200 0 0
Post-translational protein phosphorylation R-HSA-8957275 6.340311e-01 0.198 0 0
HATs acetylate histones R-HSA-3214847 6.374020e-01 0.196 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 6.374020e-01 0.196 0 0
Vesicle-mediated transport R-HSA-5653656 6.436734e-01 0.191 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 6.471339e-01 0.189 0 0
Regulation of endogenous retroelements R-HSA-9842860 6.473310e-01 0.189 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 6.473310e-01 0.189 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 6.473310e-01 0.189 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 6.505803e-01 0.187 0 0
Response of endothelial cells to shear stress R-HSA-9860931 6.537998e-01 0.185 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 6.569899e-01 0.182 0 0
RSV-host interactions R-HSA-9833110 6.569899e-01 0.182 0 0
Nucleotide Excision Repair R-HSA-5696398 6.601507e-01 0.180 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 6.623269e-01 0.179 0 0
Synthesis of DNA R-HSA-69239 6.663859e-01 0.176 0 0
Gene Silencing by RNA R-HSA-211000 6.663859e-01 0.176 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 6.694608e-01 0.174 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 6.694608e-01 0.174 0 0
Stimuli-sensing channels R-HSA-2672351 6.694608e-01 0.174 0 0
DNA Replication Pre-Initiation R-HSA-69002 6.725075e-01 0.172 0 0
TCR signaling R-HSA-202403 6.755263e-01 0.170 0 0
DNA Repair R-HSA-73894 6.810726e-01 0.167 0 0
Metabolism of nucleotides R-HSA-15869 6.835760e-01 0.165 0 0
Cell surface interactions at the vascular wall R-HSA-202733 6.856401e-01 0.164 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 6.873277e-01 0.163 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 6.902108e-01 0.161 0 0
Eukaryotic Translation Initiation R-HSA-72613 6.987026e-01 0.156 0 0
Cap-dependent Translation Initiation R-HSA-72737 6.987026e-01 0.156 0 0
Mitochondrial biogenesis R-HSA-1592230 7.014815e-01 0.154 0 0
Mitotic Prophase R-HSA-68875 7.096664e-01 0.149 0 0
Cellular response to heat stress R-HSA-3371556 7.123448e-01 0.147 0 0
Chromosome Maintenance R-HSA-73886 7.123448e-01 0.147 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 7.176283e-01 0.144 0 0
Host Interactions of HIV factors R-HSA-162909 7.202338e-01 0.143 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 7.204340e-01 0.142 0 0
Interferon Signaling R-HSA-913531 7.204340e-01 0.142 0 0
Regulation of Complement cascade R-HSA-977606 7.228154e-01 0.141 0 0
G1/S Transition R-HSA-69206 7.253734e-01 0.139 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 7.253734e-01 0.139 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 7.253734e-01 0.139 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 7.253734e-01 0.139 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 7.279079e-01 0.138 0 0
G2/M Checkpoints R-HSA-69481 7.304191e-01 0.136 0 0
Adipogenesis R-HSA-9843745 7.426343e-01 0.129 0 0
Circadian clock R-HSA-9909396 7.450105e-01 0.128 0 0
Cellular responses to stress R-HSA-2262752 7.451215e-01 0.128 1 0
Cellular responses to stimuli R-HSA-8953897 7.516416e-01 0.124 1 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 7.588171e-01 0.120 0 0
Mitochondrial translation R-HSA-5368287 7.610449e-01 0.119 0 0
PTEN Regulation R-HSA-6807070 7.632523e-01 0.117 0 0
Clathrin-mediated endocytosis R-HSA-8856828 7.739889e-01 0.111 0 0
Complement cascade R-HSA-166658 7.781469e-01 0.109 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 7.801973e-01 0.108 0 0
Visual phototransduction R-HSA-2187338 7.822288e-01 0.107 0 0
S Phase R-HSA-69242 7.842418e-01 0.106 0 0
DNA Replication R-HSA-69306 7.940325e-01 0.100 0 0
DNA Double-Strand Break Repair R-HSA-5693532 7.940325e-01 0.100 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 7.978241e-01 0.098 0 0
PPARA activates gene expression R-HSA-1989781 7.978241e-01 0.098 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.015463e-01 0.096 0 0
Innate Immune System R-HSA-168249 8.030719e-01 0.095 1 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 8.161199e-01 0.088 0 0
Organelle biogenesis and maintenance R-HSA-1852241 8.218446e-01 0.085 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 8.257636e-01 0.083 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.273765e-01 0.082 0 0
Leishmania parasite growth and survival R-HSA-9664433 8.305580e-01 0.081 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 8.305580e-01 0.081 0 0
Extracellular matrix organization R-HSA-1474244 8.352856e-01 0.078 0 0
Influenza Infection R-HSA-168255 8.397573e-01 0.076 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 8.526341e-01 0.069 0 0
Ion channel transport R-HSA-983712 8.539998e-01 0.069 0 0
Cilium Assembly R-HSA-5617833 8.553530e-01 0.068 0 0
Post-translational protein modification R-HSA-597592 8.569117e-01 0.067 0 0
GPCR downstream signalling R-HSA-388396 8.598019e-01 0.066 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 8.718508e-01 0.060 0 0
Muscle contraction R-HSA-397014 8.832573e-01 0.054 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 8.832573e-01 0.054 0 0
M Phase R-HSA-68886 8.872563e-01 0.052 0 0
Mitotic Anaphase R-HSA-68882 8.875322e-01 0.052 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 8.885764e-01 0.051 0 0
SARS-CoV-2-host interactions R-HSA-9705683 8.994461e-01 0.046 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.003803e-01 0.046 0 0
rRNA processing R-HSA-72312 9.031318e-01 0.044 0 0
Cell Cycle R-HSA-1640170 9.064069e-01 0.043 0 0
Cell Cycle, Mitotic R-HSA-69278 9.090227e-01 0.041 0 0
Signaling by NOTCH R-HSA-157118 9.101055e-01 0.041 0 0
Signaling by GPCR R-HSA-372790 9.104724e-01 0.041 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.164652e-01 0.038 0 0
Translation R-HSA-72766 9.207879e-01 0.036 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 9.225917e-01 0.035 0 0
Cell Cycle Checkpoints R-HSA-69620 9.240260e-01 0.034 0 0
G alpha (q) signalling events R-HSA-416476 9.281725e-01 0.032 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.393108e-01 0.027 0 0
Phospholipid metabolism R-HSA-1483257 9.462711e-01 0.024 0 0
Transmission across Chemical Synapses R-HSA-112315 9.586844e-01 0.018 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.676415e-01 0.014 0 0
Bacterial Infection Pathways R-HSA-9824439 9.782137e-01 0.010 1 0
Fatty acid metabolism R-HSA-8978868 9.814428e-01 0.008 0 0
Metabolism of proteins R-HSA-392499 9.835668e-01 0.007 0 0
Transport of small molecules R-HSA-382551 9.841594e-01 0.007 0 0
Neutrophil degranulation R-HSA-6798695 9.884347e-01 0.005 0 0
Neuronal System R-HSA-112316 9.895794e-01 0.005 0 0
Sensory Perception R-HSA-9709957 9.999200e-01 0.000 0 0
Metabolism of lipids R-HSA-556833 9.999372e-01 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 0.000 0 0
MyD88-independent TLR4 cascade R-HSA-166166 1.000000e+00 0.000 1 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 1.000000e+00 0.000 1 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 1.000000e+00 0.000 1 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 1.000000e+00 0.000 1 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 1.000000e+00 0.000 1 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 1.000000e+00 0.000 1 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.000000e+00 0.000 1 1
Cellular Senescence R-HSA-2559583 1.000000e+00 0.000 1 0
Interleukin-1 family signaling R-HSA-446652 1.000000e+00 0.000 1 0
Interleukin-17 signaling R-HSA-448424 1.000000e+00 0.000 1 0
MAP kinase activation R-HSA-450294 1.000000e+00 0.000 1 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 1.000000e+00 0.000 1 1
Uptake and function of anthrax toxins R-HSA-5210891 1.000000e+00 0.000 1 1
Uptake and actions of bacterial toxins R-HSA-5339562 1.000000e+00 0.000 1 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 1.000000e+00 0.000 1 1
Interleukin-1 signaling R-HSA-9020702 1.000000e+00 0.000 1 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 1.000000e+00 0.000 1 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 1.000000e+00 0.000 1 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 1.000000e+00 0.000 1 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 1.000000e+00 0.000 1 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 2.220446e-16 15.654 0 0
Axon guidance R-HSA-422475 5.551115e-16 15.256 0 0
Nervous system development R-HSA-9675108 1.332268e-14 13.875 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 6.505907e-14 13.187 0 0
Cell Cycle R-HSA-1640170 1.365907e-12 11.865 0 0
Cell Cycle, Mitotic R-HSA-69278 9.209744e-12 11.036 0 0
mRNA Splicing - Major Pathway R-HSA-72163 6.931944e-11 10.159 0 0
mRNA Splicing R-HSA-72172 5.773245e-10 9.239 0 0
Cellular response to heat stress R-HSA-3371556 1.173337e-09 8.931 0 0
Metabolism of RNA R-HSA-8953854 1.709705e-09 8.767 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 3.772042e-09 8.423 0 0
Signaling by ALK in cancer R-HSA-9700206 3.772042e-09 8.423 0 0
M Phase R-HSA-68886 7.530470e-09 8.123 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 8.823109e-09 8.054 0 0
Signal Transduction R-HSA-162582 1.001430e-08 7.999 0 0
Apoptotic execution phase R-HSA-75153 1.244615e-08 7.905 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.846533e-08 7.734 0 0
EPH-Ephrin signaling R-HSA-2682334 2.602602e-08 7.585 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 3.950092e-08 7.403 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 6.818671e-08 7.166 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.788569e-07 6.747 0 0
Cellular responses to stress R-HSA-2262752 2.848967e-07 6.545 1 0
Apoptotic cleavage of cellular proteins R-HSA-111465 2.846630e-07 6.546 0 0
mRNA 3'-end processing R-HSA-72187 3.540004e-07 6.451 0 0
Signaling by VEGF R-HSA-194138 3.809326e-07 6.419 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 4.640354e-07 6.333 0 0
Cellular responses to stimuli R-HSA-8953897 4.630861e-07 6.334 1 0
Mitotic Prometaphase R-HSA-68877 4.757854e-07 6.323 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 5.229488e-07 6.282 0 0
L1CAM interactions R-HSA-373760 7.572745e-07 6.121 0 0
Recycling pathway of L1 R-HSA-437239 7.890383e-07 6.103 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 8.032341e-07 6.095 0 0
Mitotic Anaphase R-HSA-68882 8.801935e-07 6.055 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.010676e-06 5.995 0 0
Apoptosis R-HSA-109581 1.353957e-06 5.868 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.577099e-06 5.802 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.964223e-06 5.707 0 0
Signaling by ERBB2 R-HSA-1227986 3.545366e-06 5.450 0 0
Cell Cycle Checkpoints R-HSA-69620 3.785090e-06 5.422 0 0
PIP3 activates AKT signaling R-HSA-1257604 3.879993e-06 5.411 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 5.156845e-06 5.288 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 5.798120e-06 5.237 0 0
Ephrin signaling R-HSA-3928664 9.029669e-06 5.044 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.052722e-05 4.978 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.256018e-05 4.901 0 0
Signaling by FGFR in disease R-HSA-1226099 1.357042e-05 4.867 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.565994e-05 4.805 0 0
Separation of Sister Chromatids R-HSA-2467813 1.617537e-05 4.791 0 0
MAPK family signaling cascades R-HSA-5683057 1.665482e-05 4.778 0 0
RAF/MAP kinase cascade R-HSA-5673001 2.008501e-05 4.697 0 0
Programmed Cell Death R-HSA-5357801 2.166951e-05 4.664 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 2.362266e-05 4.627 0 0
Membrane Trafficking R-HSA-199991 2.523545e-05 4.598 0 0
Signaling by Interleukins R-HSA-449147 2.606130e-05 4.584 1 0
Transcriptional Regulation by TP53 R-HSA-3700989 3.023648e-05 4.519 0 0
Post NMDA receptor activation events R-HSA-438064 3.815310e-05 4.418 0 0
Cellular Senescence R-HSA-2559583 3.997291e-05 4.398 1 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 4.664817e-05 4.331 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 4.599245e-05 4.337 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 4.701755e-05 4.328 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 4.680325e-05 4.330 0 0
G2/M Transition R-HSA-69275 4.438759e-05 4.353 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 5.043236e-05 4.297 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 5.560681e-05 4.255 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 5.713792e-05 4.243 0 0
Cytokine Signaling in Immune system R-HSA-1280215 6.172325e-05 4.210 1 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 6.257954e-05 4.204 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 7.333027e-05 4.135 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 8.424110e-05 4.074 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 9.158017e-05 4.038 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 9.272871e-05 4.033 0 0
Cell-Cell communication R-HSA-1500931 9.390177e-05 4.027 0 0
FLT3 Signaling R-HSA-9607240 9.588155e-05 4.018 0 0
Signaling by ROBO receptors R-HSA-376176 9.543566e-05 4.020 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.873971e-05 4.006 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.176559e-04 3.929 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.227921e-04 3.911 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.392391e-04 3.856 0 0
Semaphorin interactions R-HSA-373755 1.396037e-04 3.855 0 0
HIV Infection R-HSA-162906 1.406846e-04 3.852 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.411858e-04 3.850 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.616425e-04 3.791 0 0
MTOR signalling R-HSA-165159 1.600064e-04 3.796 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.760664e-04 3.754 0 0
Aggrephagy R-HSA-9646399 2.139679e-04 3.670 0 0
Attenuation phase R-HSA-3371568 2.139679e-04 3.670 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 2.139679e-04 3.670 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.275097e-04 3.643 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 2.277544e-04 3.643 0 0
Death Receptor Signaling R-HSA-73887 2.336648e-04 3.631 0 0
Selective autophagy R-HSA-9663891 2.372853e-04 3.625 0 0
Regulation of CDH1 Function R-HSA-9764561 2.539387e-04 3.595 0 0
Developmental Biology R-HSA-1266738 2.706433e-04 3.568 0 0
Interleukin-12 signaling R-HSA-9020591 2.905258e-04 3.537 0 0
SARS-CoV-1-host interactions R-HSA-9692914 3.011505e-04 3.521 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 3.112670e-04 3.507 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 3.413215e-04 3.467 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 3.413215e-04 3.467 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 3.361774e-04 3.473 0 0
HIV Life Cycle R-HSA-162587 3.333797e-04 3.477 0 0
Translation initiation complex formation R-HSA-72649 3.428273e-04 3.465 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.699011e-04 3.432 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 3.909753e-04 3.408 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 4.010216e-04 3.397 0 0
Eukaryotic Translation Initiation R-HSA-72613 3.979715e-04 3.400 0 0
Cap-dependent Translation Initiation R-HSA-72737 3.979715e-04 3.400 0 0
Nuclear import of Rev protein R-HSA-180746 3.820348e-04 3.418 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 4.036148e-04 3.394 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 3.677074e-04 3.434 0 0
Insulin receptor signalling cascade R-HSA-74751 4.124212e-04 3.385 0 0
Signaling by Hippo R-HSA-2028269 4.202684e-04 3.376 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 4.397560e-04 3.357 0 0
HSF1-dependent transactivation R-HSA-3371571 4.631805e-04 3.334 0 0
Regulation of TP53 Activity R-HSA-5633007 4.696483e-04 3.328 0 0
Signalling to ERKs R-HSA-187687 4.931772e-04 3.307 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 5.071066e-04 3.295 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 5.117086e-04 3.291 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 5.123448e-04 3.290 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 5.123448e-04 3.290 0 0
Signaling by SCF-KIT R-HSA-1433557 5.509951e-04 3.259 0 0
Centrosome maturation R-HSA-380287 5.515921e-04 3.258 0 0
ISG15 antiviral mechanism R-HSA-1169408 5.515921e-04 3.258 0 0
PKR-mediated signaling R-HSA-9833482 5.719452e-04 3.243 0 0
AURKA Activation by TPX2 R-HSA-8854518 5.943653e-04 3.226 0 0
Oncogenic MAPK signaling R-HSA-6802957 5.877327e-04 3.231 0 0
Nuclear Envelope Breakdown R-HSA-2980766 6.225742e-04 3.206 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 6.612949e-04 3.180 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 7.996388e-04 3.097 0 0
Regulation of signaling by CBL R-HSA-912631 8.489746e-04 3.071 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 8.863442e-04 3.052 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 8.493494e-04 3.071 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 8.493494e-04 3.071 0 0
Interleukin-37 signaling R-HSA-9008059 8.863442e-04 3.052 0 0
Signaling by RAF1 mutants R-HSA-9656223 9.279885e-04 3.032 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 9.279885e-04 3.032 0 0
Signaling by RAS mutants R-HSA-6802949 1.041392e-03 2.982 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.041392e-03 2.982 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.041392e-03 2.982 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.041392e-03 2.982 0 0
Host Interactions of HIV factors R-HSA-162909 1.100376e-03 2.958 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.134613e-03 2.945 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 1.171848e-03 2.931 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.171848e-03 2.931 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.221693e-03 2.913 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 1.288817e-03 2.890 0 0
MAP kinase activation R-HSA-450294 1.288817e-03 2.890 1 0
Late Phase of HIV Life Cycle R-HSA-162599 1.215545e-03 2.915 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.192806e-03 2.923 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.239284e-03 2.907 0 0
Regulation of KIT signaling R-HSA-1433559 1.359536e-03 2.867 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 1.521555e-03 2.818 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.528775e-03 2.816 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.543648e-03 2.811 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.588394e-03 2.799 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.608368e-03 2.794 0 0
HSF1 activation R-HSA-3371511 1.705335e-03 2.768 0 0
Cell junction organization R-HSA-446728 1.780655e-03 2.749 0 0
G2/M Checkpoints R-HSA-69481 1.750906e-03 2.757 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.805804e-03 2.743 0 0
Signaling by PTK6 R-HSA-8848021 1.805804e-03 2.743 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.830007e-03 2.738 0 0
Interleukin-12 family signaling R-HSA-447115 1.900425e-03 2.721 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.953003e-03 2.709 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.974925e-03 2.704 0 0
Sema4D in semaphorin signaling R-HSA-400685 2.073033e-03 2.683 0 0
Nef and signal transduction R-HSA-164944 2.093241e-03 2.679 0 0
Transport of connexons to the plasma membrane R-HSA-190872 2.093428e-03 2.679 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 2.116151e-03 2.674 0 0
IGF1R signaling cascade R-HSA-2428924 2.124344e-03 2.673 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 2.348811e-03 2.629 0 0
Kinesins R-HSA-983189 2.431831e-03 2.614 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.462340e-03 2.609 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 2.489182e-03 2.604 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 2.506766e-03 2.601 0 0
Activation of BH3-only proteins R-HSA-114452 2.506766e-03 2.601 0 0
Interleukin-17 signaling R-HSA-448424 2.523936e-03 2.598 1 0
Signaling by FGFR R-HSA-190236 2.729603e-03 2.564 0 0
mTORC1-mediated signalling R-HSA-166208 2.790098e-03 2.554 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 3.014073e-03 2.521 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 3.150545e-03 2.502 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 3.150545e-03 2.502 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 3.150545e-03 2.502 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.886439e-03 2.540 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.886439e-03 2.540 0 0
Signal attenuation R-HSA-74749 3.014073e-03 2.521 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 3.185949e-03 2.497 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 3.185949e-03 2.497 0 0
Estrogen-dependent gene expression R-HSA-9018519 3.197127e-03 2.495 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 3.220752e-03 2.492 0 0
IRS-mediated signalling R-HSA-112399 3.276675e-03 2.485 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 3.317765e-03 2.479 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 3.317765e-03 2.479 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 3.405471e-03 2.468 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 3.405471e-03 2.468 0 0
IFNG signaling activates MAPKs R-HSA-9732724 3.497689e-03 2.456 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 3.537816e-03 2.451 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 3.672222e-03 2.435 0 0
Nephrin family interactions R-HSA-373753 3.752221e-03 2.426 0 0
Smooth Muscle Contraction R-HSA-445355 3.753768e-03 2.426 0 0
Clathrin-mediated endocytosis R-HSA-8856828 4.103396e-03 2.387 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 4.487636e-03 2.348 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 4.632925e-03 2.334 0 0
HIV elongation arrest and recovery R-HSA-167287 4.292803e-03 2.367 0 0
Pausing and recovery of HIV elongation R-HSA-167290 4.292803e-03 2.367 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 4.664821e-03 2.331 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 4.580401e-03 2.339 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 4.580401e-03 2.339 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 4.407266e-03 2.356 1 1
Platelet activation, signaling and aggregation R-HSA-76002 4.703377e-03 2.328 0 0
PECAM1 interactions R-HSA-210990 4.487636e-03 2.348 0 0
Chromatin organization R-HSA-4839726 4.182255e-03 2.379 0 0
Mitotic Prophase R-HSA-68875 4.220759e-03 2.375 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 4.474937e-03 2.349 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 4.841419e-03 2.315 0 0
Autophagy R-HSA-9612973 4.901124e-03 2.310 0 0
Uptake and function of anthrax toxins R-HSA-5210891 5.038334e-03 2.298 1 1
Signaling by FGFR2 R-HSA-5654738 5.053047e-03 2.296 0 0
PI3K Cascade R-HSA-109704 5.071642e-03 2.295 0 0
Macroautophagy R-HSA-1632852 5.218125e-03 2.282 0 0
Regulation of PTEN gene transcription R-HSA-8943724 5.225536e-03 2.282 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 5.269973e-03 2.278 0 0
Influenza Infection R-HSA-168255 5.568815e-03 2.254 0 0
MAP2K and MAPK activation R-HSA-5674135 5.590094e-03 2.253 0 0
Signaling by FGFR1 in disease R-HSA-5655302 5.590094e-03 2.253 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 5.739101e-03 2.241 0 0
Gene expression (Transcription) R-HSA-74160 5.762287e-03 2.239 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 5.766694e-03 2.239 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 5.860670e-03 2.232 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 5.860670e-03 2.232 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 5.925194e-03 2.227 0 0
Signaling by EGFR R-HSA-177929 6.036005e-03 2.219 0 0
TNF signaling R-HSA-75893 6.036005e-03 2.219 0 0
NRAGE signals death through JNK R-HSA-193648 6.036005e-03 2.219 0 0
ESR-mediated signaling R-HSA-8939211 6.204789e-03 2.207 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 6.312354e-03 2.200 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 6.312354e-03 2.200 0 0
Signaling by PDGFR in disease R-HSA-9671555 6.312605e-03 2.200 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 6.312605e-03 2.200 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 6.339429e-03 2.198 0 0
SARS-CoV-1 Infection R-HSA-9678108 6.400991e-03 2.194 0 0
S Phase R-HSA-69242 6.525080e-03 2.185 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 6.619470e-03 2.179 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 6.644055e-03 2.178 0 0
Formation of a pool of free 40S subunits R-HSA-72689 6.668950e-03 2.176 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 6.746014e-03 2.171 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 6.746014e-03 2.171 0 0
GP1b-IX-V activation signalling R-HSA-430116 8.245272e-03 2.084 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 8.245272e-03 2.084 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 8.245272e-03 2.084 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 7.764984e-03 2.110 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 8.615760e-03 2.065 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 8.668823e-03 2.062 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 8.668823e-03 2.062 0 0
Prolonged ERK activation events R-HSA-169893 9.002901e-03 2.046 0 0
Interleukin-2 family signaling R-HSA-451927 9.050582e-03 2.043 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 9.050582e-03 2.043 0 0
Gap junction trafficking R-HSA-190828 9.282833e-03 2.032 0 0
Metabolism of non-coding RNA R-HSA-194441 9.338604e-03 2.030 0 0
snRNP Assembly R-HSA-191859 9.338604e-03 2.030 0 0
Gap junction trafficking and regulation R-HSA-157858 9.393137e-03 2.027 0 0
Diseases of mitotic cell cycle R-HSA-9675126 9.842687e-03 2.007 0 0
Interleukin receptor SHC signaling R-HSA-912526 1.006057e-02 1.997 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.006057e-02 1.997 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.009419e-02 1.996 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.014008e-02 1.994 0 0
RET signaling R-HSA-8853659 1.037095e-02 1.984 0 0
Signaling by NTRKs R-HSA-166520 1.063784e-02 1.973 0 0
Signaling by FGFR2 in disease R-HSA-5655253 1.091326e-02 1.962 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.100207e-02 1.959 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 1.184962e-02 1.926 0 0
Frs2-mediated activation R-HSA-170968 1.218540e-02 1.914 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 1.218540e-02 1.914 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.178010e-02 1.929 0 0
Signaling by Erythropoietin R-HSA-9006335 1.350177e-02 1.870 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 1.350177e-02 1.870 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.185407e-02 1.926 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.185407e-02 1.926 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.232250e-02 1.909 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.266551e-02 1.897 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.266551e-02 1.897 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 1.350177e-02 1.870 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.320032e-02 1.879 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 1.206800e-02 1.918 1 0
TP53 Regulates Metabolic Genes R-HSA-5628897 1.200028e-02 1.921 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.330897e-02 1.876 0 0
RNA Polymerase II Transcription R-HSA-73857 1.229244e-02 1.910 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.330897e-02 1.876 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.163567e-02 1.934 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.184962e-02 1.926 0 0
Chromatin modifying enzymes R-HSA-3247509 1.134177e-02 1.945 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.385194e-02 1.858 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.385194e-02 1.858 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 1.385194e-02 1.858 1 1
Eukaryotic Translation Elongation R-HSA-156842 1.395509e-02 1.855 0 0
Striated Muscle Contraction R-HSA-390522 1.416700e-02 1.849 0 0
G alpha (12/13) signalling events R-HSA-416482 1.425071e-02 1.846 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 1.456140e-02 1.837 0 0
Interferon Signaling R-HSA-913531 1.493100e-02 1.826 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.514115e-02 1.820 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.514115e-02 1.820 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.531543e-02 1.815 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.567158e-02 1.805 0 0
Signaling by FGFR4 in disease R-HSA-5655291 1.613473e-02 1.792 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.662292e-02 1.779 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 2.031501e-02 1.692 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 2.031501e-02 1.692 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 2.031501e-02 1.692 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 2.031501e-02 1.692 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 2.031501e-02 1.692 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 2.031501e-02 1.692 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 2.031501e-02 1.692 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 2.031501e-02 1.692 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 2.031501e-02 1.692 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 2.031501e-02 1.692 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 2.031501e-02 1.692 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 2.031501e-02 1.692 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.889688e-02 1.724 0 0
IRS activation R-HSA-74713 1.889688e-02 1.724 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.889688e-02 1.724 0 0
Erythropoietin activates RAS R-HSA-9027284 2.091419e-02 1.680 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 2.091419e-02 1.680 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 1.721383e-02 1.764 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.857864e-02 1.731 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 1.706357e-02 1.768 0 0
HIV Transcription Elongation R-HSA-167169 1.989810e-02 1.701 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 1.989810e-02 1.701 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 1.989810e-02 1.701 0 0
Degradation of CDH1 R-HSA-9766229 1.945213e-02 1.711 0 0
PTEN Regulation R-HSA-6807070 1.908387e-02 1.719 0 0
Deubiquitination R-HSA-5688426 1.993962e-02 1.700 0 0
Adherens junctions interactions R-HSA-418990 1.880061e-02 1.726 0 0
Myogenesis R-HSA-525793 1.857864e-02 1.731 0 0
DCC mediated attractive signaling R-HSA-418885 2.091419e-02 1.680 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 1.937203e-02 1.713 1 0
MyD88-independent TLR4 cascade R-HSA-166166 1.937203e-02 1.713 1 0
p38MAPK events R-HSA-171007 2.091419e-02 1.680 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.740579e-02 1.759 0 0
Oncogene Induced Senescence R-HSA-2559585 1.980339e-02 1.703 0 0
Vesicle-mediated transport R-HSA-5653656 2.010749e-02 1.697 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.680094e-02 1.775 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.914770e-02 1.718 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.857864e-02 1.731 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 1.914770e-02 1.718 0 0
G1/S Transition R-HSA-69206 2.106996e-02 1.676 0 0
Signaling by KIT in disease R-HSA-9669938 2.113480e-02 1.675 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 2.113480e-02 1.675 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 2.113480e-02 1.675 0 0
Formation of annular gap junctions R-HSA-196025 2.200954e-02 1.657 0 0
Activation of RAC1 R-HSA-428540 2.213008e-02 1.655 0 0
Signaling by FGFR3 R-HSA-5654741 2.273701e-02 1.643 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 2.273701e-02 1.643 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.273701e-02 1.643 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 2.307165e-02 1.637 0 0
RUNX2 regulates bone development R-HSA-8941326 2.317913e-02 1.635 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.385813e-02 1.622 0 0
Signaling by Insulin receptor R-HSA-74752 2.421843e-02 1.616 0 0
DNA Double-Strand Break Repair R-HSA-5693532 2.465640e-02 1.608 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.515263e-02 1.599 0 0
Peptide chain elongation R-HSA-156902 2.557899e-02 1.592 0 0
Growth hormone receptor signaling R-HSA-982772 2.565971e-02 1.591 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 2.603585e-02 1.584 0 0
MHC class II antigen presentation R-HSA-2132295 2.634803e-02 1.579 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 2.653165e-02 1.576 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 2.663284e-02 1.575 0 0
Ovarian tumor domain proteases R-HSA-5689896 2.696037e-02 1.569 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 2.699842e-02 1.569 0 0
Activation of ATR in response to replication stress R-HSA-176187 2.701013e-02 1.568 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 2.755143e-02 1.560 1 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 2.755143e-02 1.560 1 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 2.755143e-02 1.560 1 0
Ribosome-associated quality control R-HSA-9948299 2.761606e-02 1.559 0 0
Transcription of the HIV genome R-HSA-167172 2.836351e-02 1.547 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 2.838396e-02 1.547 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.889187e-02 1.539 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.889187e-02 1.539 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.889187e-02 1.539 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.901533e-02 1.537 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.901533e-02 1.537 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 2.901533e-02 1.537 0 0
Regulation of IFNG signaling R-HSA-877312 2.901533e-02 1.537 0 0
Signal transduction by L1 R-HSA-445144 2.932639e-02 1.533 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 2.972100e-02 1.527 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.977460e-02 1.526 0 0
Gap junction degradation R-HSA-190873 3.035955e-02 1.518 0 0
ALK mutants bind TKIs R-HSA-9700645 3.035955e-02 1.518 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 3.083039e-02 1.511 0 0
Signaling by MET R-HSA-6806834 3.146361e-02 1.502 0 0
Cell-cell junction organization R-HSA-421270 3.162898e-02 1.500 0 0
TCR signaling R-HSA-202403 3.166212e-02 1.499 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 3.322437e-02 1.479 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 3.325071e-02 1.478 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 3.325071e-02 1.478 0 0
Nucleotide Excision Repair R-HSA-5696398 3.366677e-02 1.473 0 0
Diseases of Telomere Maintenance R-HSA-9673013 3.374065e-02 1.472 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 3.374065e-02 1.472 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 3.374065e-02 1.472 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 3.374065e-02 1.472 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 3.374065e-02 1.472 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 3.390709e-02 1.470 0 0
Interleukin-1 family signaling R-HSA-446652 3.478708e-02 1.459 1 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 3.478708e-02 1.459 0 0
Signaling by FGFR4 R-HSA-5654743 3.483926e-02 1.458 0 0
MET interacts with TNS proteins R-HSA-8875513 3.578363e-02 1.446 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 3.578363e-02 1.446 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 4.150349e-02 1.382 0 0
Signaling by LTK in cancer R-HSA-9842640 4.150349e-02 1.382 0 0
Erythropoietin activates STAT5 R-HSA-9027283 4.150349e-02 1.382 0 0
MAPK3 (ERK1) activation R-HSA-110056 4.046461e-02 1.393 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 3.717605e-02 1.430 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 3.717605e-02 1.430 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 4.667248e-02 1.331 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 4.667248e-02 1.331 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 4.667248e-02 1.331 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 4.092797e-02 1.388 0 0
Signaling by EGFR in Cancer R-HSA-1643713 4.325695e-02 1.364 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 3.691595e-02 1.433 0 0
Downstream signal transduction R-HSA-186763 4.296943e-02 1.367 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 3.656999e-02 1.437 0 0
RAF activation R-HSA-5673000 3.656999e-02 1.437 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 3.656999e-02 1.437 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 3.583461e-02 1.446 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 3.505247e-02 1.455 0 0
Protein folding R-HSA-391251 4.048858e-02 1.393 0 0
Chaperonin-mediated protein folding R-HSA-390466 3.939499e-02 1.405 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 4.294986e-02 1.367 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 4.272301e-02 1.369 0 0
UCH proteinases R-HSA-5689603 3.669553e-02 1.435 0 0
Signaling by Leptin R-HSA-2586552 4.046461e-02 1.393 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 4.283364e-02 1.368 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 4.576865e-02 1.339 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 3.656999e-02 1.437 0 0
Developmental Cell Lineages R-HSA-9734767 4.295032e-02 1.367 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 4.046461e-02 1.393 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 4.296943e-02 1.367 0 0
Long-term potentiation R-HSA-9620244 3.668492e-02 1.436 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 4.660168e-02 1.332 0 0
Signalling to RAS R-HSA-167044 3.560077e-02 1.449 0 0
Viral Messenger RNA Synthesis R-HSA-168325 4.326648e-02 1.364 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 4.272301e-02 1.369 0 0
Inositol phosphate metabolism R-HSA-1483249 3.723700e-02 1.429 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 3.957718e-02 1.403 0 0
SARS-CoV Infections R-HSA-9679506 3.640906e-02 1.439 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 4.560440e-02 1.341 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 4.560440e-02 1.341 0 0
Switching of origins to a post-replicative state R-HSA-69052 4.715918e-02 1.326 0 0
tRNA processing in the nucleus R-HSA-6784531 4.799840e-02 1.319 0 0
Regulation of TP53 Degradation R-HSA-6804757 4.827945e-02 1.316 0 0
G1/S-Specific Transcription R-HSA-69205 4.827945e-02 1.316 0 0
GPVI-mediated activation cascade R-HSA-114604 4.827945e-02 1.316 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 4.827945e-02 1.316 0 0
Chaperone Mediated Autophagy R-HSA-9613829 4.967297e-02 1.304 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 4.967297e-02 1.304 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 5.004510e-02 1.301 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 5.038246e-02 1.298 0 0
Signaling by FGFR3 in disease R-HSA-5655332 5.057514e-02 1.296 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 5.205212e-02 1.284 0 0
Negative regulation of MAPK pathway R-HSA-5675221 5.274203e-02 1.278 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 5.506179e-02 1.259 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 5.553378e-02 1.255 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 5.581277e-02 1.253 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 5.581277e-02 1.253 0 0
Signaling by MAP2K mutants R-HSA-9652169 5.581277e-02 1.253 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 5.581277e-02 1.253 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 5.638425e-02 1.249 0 0
Eukaryotic Translation Termination R-HSA-72764 5.638425e-02 1.249 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 5.676768e-02 1.246 0 0
SOS-mediated signalling R-HSA-112412 5.676768e-02 1.246 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 5.676768e-02 1.246 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 5.676768e-02 1.246 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 5.676768e-02 1.246 0 0
G-protein beta:gamma signalling R-HSA-397795 5.702332e-02 1.244 0 0
FGFR1 mutant receptor activation R-HSA-1839124 5.702332e-02 1.244 0 0
Integrin signaling R-HSA-354192 5.702332e-02 1.244 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 5.702332e-02 1.244 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 5.702332e-02 1.244 0 0
Viral Infection Pathways R-HSA-9824446 5.725903e-02 1.242 0 0
Spry regulation of FGF signaling R-HSA-1295596 5.754425e-02 1.240 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 5.866267e-02 1.232 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 5.926617e-02 1.227 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 5.951682e-02 1.225 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 5.960116e-02 1.225 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 5.964051e-02 1.224 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 5.964051e-02 1.224 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 6.267438e-02 1.203 0 0
Co-stimulation by CD28 R-HSA-389356 6.305716e-02 1.200 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 6.580003e-02 1.182 0 0
Potential therapeutics for SARS R-HSA-9679191 6.603076e-02 1.180 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 6.613913e-02 1.180 0 0
TBC/RABGAPs R-HSA-8854214 6.661096e-02 1.176 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 6.664085e-02 1.176 1 0
Homology Directed Repair R-HSA-5693538 6.698531e-02 1.174 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 6.753688e-02 1.170 0 0
SARS-CoV-2 Infection R-HSA-9694516 6.861698e-02 1.164 0 0
NTRK3 as a dependence receptor R-HSA-9603505 6.923163e-02 1.160 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 6.923163e-02 1.160 0 0
Breakdown of the nuclear lamina R-HSA-352238 6.923163e-02 1.160 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 6.948003e-02 1.158 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 6.980996e-02 1.156 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 6.980996e-02 1.156 0 0
Stabilization of p53 R-HSA-69541 7.021494e-02 1.154 0 0
Co-inhibition by CTLA4 R-HSA-389513 7.047780e-02 1.152 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 7.149989e-02 1.146 1 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 7.217767e-02 1.142 0 0
PCP/CE pathway R-HSA-4086400 7.347904e-02 1.134 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 7.379061e-02 1.132 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 7.379061e-02 1.132 0 0
NOD1/2 Signaling Pathway R-HSA-168638 7.379061e-02 1.132 0 0
Gap junction assembly R-HSA-190861 7.379061e-02 1.132 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 7.463668e-02 1.127 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 7.463668e-02 1.127 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 7.463668e-02 1.127 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 7.463668e-02 1.127 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 7.658564e-02 1.116 1 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 7.661029e-02 1.116 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 7.713230e-02 1.113 0 0
Activation of the pre-replicative complex R-HSA-68962 7.720901e-02 1.112 0 0
Regulation of TP53 Expression R-HSA-6804754 1.123740e-01 0.949 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 1.123740e-01 0.949 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 1.080677e-01 0.966 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 9.499207e-02 1.022 0 0
Lipophagy R-HSA-9613354 9.499207e-02 1.022 0 0
Interleukin-21 signaling R-HSA-9020958 9.499207e-02 1.022 0 0
WNT mediated activation of DVL R-HSA-201688 9.499207e-02 1.022 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 9.499207e-02 1.022 0 0
MAPK1 (ERK2) activation R-HSA-112411 9.499207e-02 1.022 0 0
p75NTR recruits signalling complexes R-HSA-209543 8.171213e-02 1.088 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 8.171213e-02 1.088 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 8.171213e-02 1.088 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 8.171213e-02 1.088 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.176585e-01 0.929 0 0
PI3K/AKT activation R-HSA-198203 1.176585e-01 0.929 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.176585e-01 0.929 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 1.176585e-01 0.929 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 9.905227e-02 1.004 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 9.905227e-02 1.004 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 9.905227e-02 1.004 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 9.575961e-02 1.019 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 9.575961e-02 1.019 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 9.575961e-02 1.019 0 0
TGFBR3 expression R-HSA-9839394 8.025526e-02 1.096 0 0
FGFR2 alternative splicing R-HSA-6803529 1.100531e-01 0.958 0 0
EGFR downregulation R-HSA-182971 8.768402e-02 1.057 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.046059e-01 0.980 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 1.046059e-01 0.980 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 8.321929e-02 1.080 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 7.874552e-02 1.104 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 1.110310e-01 0.955 0 0
Degradation of DVL R-HSA-4641258 1.041809e-01 0.982 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.153150e-02 1.038 0 0
MET promotes cell motility R-HSA-8875878 1.157053e-01 0.937 0 0
Orc1 removal from chromatin R-HSA-68949 9.433688e-02 1.025 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 9.433688e-02 1.025 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.034219e-01 0.985 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.144634e-01 0.941 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.144634e-01 0.941 0 0
Nuclear Receptor transcription pathway R-HSA-383280 1.161805e-01 0.935 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.369715e-02 1.028 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 9.196664e-02 1.036 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.335002e-02 1.030 0 0
Interleukin-15 signaling R-HSA-8983432 8.171213e-02 1.088 0 0
Signaling by FGFR1 R-HSA-5654736 8.034955e-02 1.095 0 0
Polo-like kinase mediated events R-HSA-156711 1.148510e-01 0.940 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.148510e-01 0.940 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.041809e-01 0.982 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.102586e-01 0.958 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 8.256123e-02 1.083 0 0
Generation of second messenger molecules R-HSA-202433 7.874552e-02 1.104 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 8.537376e-02 1.069 0 0
Synaptic adhesion-like molecules R-HSA-8849932 1.148510e-01 0.940 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 8.266730e-02 1.083 0 0
Synthesis of DNA R-HSA-69239 9.369715e-02 1.028 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 1.049448e-01 0.979 1 0
Josephin domain DUBs R-HSA-5689877 1.176585e-01 0.929 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.176585e-01 0.929 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 1.049448e-01 0.979 1 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 9.942134e-02 1.003 0 0
Regulation of CDH11 function R-HSA-9762292 1.176585e-01 0.929 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 8.321929e-02 1.080 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.064663e-01 0.973 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 1.173237e-01 0.931 1 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 9.575961e-02 1.019 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 9.334507e-02 1.030 1 0
Neurexins and neuroligins R-HSA-6794361 9.433688e-02 1.025 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 1.049448e-01 0.979 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 8.266730e-02 1.083 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 8.266730e-02 1.083 0 0
Platelet degranulation R-HSA-114608 8.637339e-02 1.064 0 0
Interleukin-6 signaling R-HSA-1059683 9.905227e-02 1.004 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.079575e-01 0.967 0 0
DNA Repair R-HSA-73894 8.189611e-02 1.087 0 0
FLT3 signaling in disease R-HSA-9682385 9.335002e-02 1.030 0 0
Signaling by TGFB family members R-HSA-9006936 1.142423e-01 0.942 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 1.080677e-01 0.966 0 0
ER to Golgi Anterograde Transport R-HSA-199977 7.925551e-02 1.101 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 1.110310e-01 0.955 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 8.789754e-02 1.056 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 9.807898e-02 1.008 0 0
PKMTs methylate histone lysines R-HSA-3214841 8.789754e-02 1.056 0 0
HATs acetylate histones R-HSA-3214847 1.148076e-01 0.940 0 0
Cilium Assembly R-HSA-5617833 1.116882e-01 0.952 0 0
Unwinding of DNA R-HSA-176974 9.499207e-02 1.022 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 1.046059e-01 0.980 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 1.110310e-01 0.955 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.006277e-01 0.997 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 9.575961e-02 1.019 0 0
Selenocysteine synthesis R-HSA-2408557 8.776727e-02 1.057 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 8.460522e-02 1.073 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 1.074020e-01 0.969 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 1.180782e-01 0.928 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 1.181565e-01 0.928 0 0
Formation of the Early Elongation Complex R-HSA-113418 1.181565e-01 0.928 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 1.214740e-01 0.916 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 1.214740e-01 0.916 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.238816e-01 0.907 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.247862e-01 0.904 0 0
Sensory processing of sound R-HSA-9659379 1.248052e-01 0.904 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 1.248120e-01 0.904 1 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 1.248120e-01 0.904 1 0
Interleukin-20 family signaling R-HSA-8854691 1.254100e-01 0.902 0 0
Syndecan interactions R-HSA-3000170 1.254100e-01 0.902 0 0
Neutrophil degranulation R-HSA-6798695 1.278674e-01 0.893 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.279119e-01 0.893 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 1.279119e-01 0.893 0 0
Generic Transcription Pathway R-HSA-212436 1.306035e-01 0.884 0 0
Netrin-1 signaling R-HSA-373752 1.306999e-01 0.884 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 1.325935e-01 0.877 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 1.325935e-01 0.877 0 0
Drug resistance of KIT mutants R-HSA-9669937 1.329952e-01 0.876 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.329952e-01 0.876 0 0
KIT mutants bind TKIs R-HSA-9669921 1.329952e-01 0.876 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.329952e-01 0.876 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.329952e-01 0.876 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.329952e-01 0.876 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 1.329952e-01 0.876 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.329952e-01 0.876 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.329952e-01 0.876 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 1.329952e-01 0.876 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 1.329952e-01 0.876 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 1.329952e-01 0.876 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.329952e-01 0.876 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 1.329952e-01 0.876 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.329952e-01 0.876 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.329952e-01 0.876 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.329952e-01 0.876 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 1.329952e-01 0.876 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 1.329952e-01 0.876 0 0
Rab regulation of trafficking R-HSA-9007101 1.335478e-01 0.874 0 0
Signaling by NOTCH4 R-HSA-9013694 1.342588e-01 0.872 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.358795e-01 0.867 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.381906e-01 0.860 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.386824e-01 0.858 0 0
p75NTR signals via NF-kB R-HSA-193639 1.386824e-01 0.858 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 1.386824e-01 0.858 0 0
Deadenylation of mRNA R-HSA-429947 1.417880e-01 0.848 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 1.417880e-01 0.848 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 1.424172e-01 0.846 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.424172e-01 0.846 0 0
Interleukin-2 signaling R-HSA-9020558 1.424172e-01 0.846 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.424172e-01 0.846 0 0
Viral mRNA Translation R-HSA-192823 1.465572e-01 0.834 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 1.478846e-01 0.830 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 1.491532e-01 0.826 1 0
Formation of definitive endoderm R-HSA-9823730 1.513055e-01 0.820 0 0
Negative regulation of MET activity R-HSA-6807004 1.513055e-01 0.820 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.513055e-01 0.820 0 0
Signaling by NODAL R-HSA-1181150 1.513055e-01 0.820 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.551377e-01 0.809 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.552047e-01 0.809 0 0
Signaling by TGFBR3 R-HSA-9839373 1.557011e-01 0.808 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 1.563121e-01 0.806 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 1.563121e-01 0.806 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 1.591348e-01 0.798 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 1.591348e-01 0.798 0 0
Interleukin-7 signaling R-HSA-1266695 1.591348e-01 0.798 0 0
Signaling by FGFR1 amplification mutants R-HSA-1839120 1.605065e-01 0.795 0 0
Signaling by FGFR2 amplification mutants R-HSA-2023837 1.605065e-01 0.795 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 1.605065e-01 0.795 0 0
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336 1.605065e-01 0.795 0 0
Axonal growth stimulation R-HSA-209563 1.605065e-01 0.795 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 1.605065e-01 0.795 0 0
MET activates PTPN11 R-HSA-8865999 1.605065e-01 0.795 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 1.605065e-01 0.795 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 1.607365e-01 0.794 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 1.607365e-01 0.794 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.607365e-01 0.794 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 1.607365e-01 0.794 0 0
Negative regulation of FLT3 R-HSA-9706369 1.607365e-01 0.794 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 1.607365e-01 0.794 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 1.609709e-01 0.793 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 1.639907e-01 0.785 0 0
Regulation of mitotic cell cycle R-HSA-453276 1.660845e-01 0.780 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 1.660845e-01 0.780 0 0
Cellular response to hypoxia R-HSA-1234174 1.673649e-01 0.776 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.683535e-01 0.774 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 1.689572e-01 0.772 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.690187e-01 0.772 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 1.690480e-01 0.772 0 0
ERK/MAPK targets R-HSA-198753 1.712457e-01 0.766 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.712457e-01 0.766 0 0
Basigin interactions R-HSA-210991 1.712457e-01 0.766 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 1.730363e-01 0.762 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 1.730363e-01 0.762 0 0
Regulation of PTEN localization R-HSA-8948747 1.730363e-01 0.762 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 1.730363e-01 0.762 0 0
CHL1 interactions R-HSA-447041 1.730363e-01 0.762 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.483093e-01 0.605 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 2.483093e-01 0.605 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.483093e-01 0.605 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.483093e-01 0.605 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.483093e-01 0.605 0 0
SARS-CoV-1 targets PDZ proteins in cell-cell junction R-HSA-9692912 2.483093e-01 0.605 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.483093e-01 0.605 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.115401e-01 0.675 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 2.115401e-01 0.675 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 2.115401e-01 0.675 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 2.115401e-01 0.675 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.115401e-01 0.675 0 0
FGFR4 mutant receptor activation R-HSA-1839128 3.482921e-01 0.458 0 0
t(4;14) translocations of FGFR3 R-HSA-2033515 3.482921e-01 0.458 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 3.482921e-01 0.458 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 3.482921e-01 0.458 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 3.482921e-01 0.458 0 0
Signaling by FGFR3 fusions in cancer R-HSA-8853334 3.482921e-01 0.458 0 0
Signaling by FGFR2 fusions R-HSA-8853333 3.482921e-01 0.458 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.482921e-01 0.458 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 3.482921e-01 0.458 0 0
Defective VWF binding to collagen type I R-HSA-9845622 3.482921e-01 0.458 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 3.482921e-01 0.458 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 3.482921e-01 0.458 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 3.482921e-01 0.458 0 0
Defective SLC26A2 causes chondrodysplasias R-HSA-3560792 3.482921e-01 0.458 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 3.482921e-01 0.458 0 0
IKBKB deficiency causes SCID R-HSA-5602636 3.482921e-01 0.458 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 3.482921e-01 0.458 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 3.482921e-01 0.458 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 3.482921e-01 0.458 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 3.482921e-01 0.458 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 3.482921e-01 0.458 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 2.638527e-01 0.579 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 2.638527e-01 0.579 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.638527e-01 0.579 0 0
Activation of AKT2 R-HSA-165158 2.638527e-01 0.579 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 2.638527e-01 0.579 0 0
G2 Phase R-HSA-68911 2.638527e-01 0.579 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 2.638527e-01 0.579 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 2.638527e-01 0.579 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 2.638527e-01 0.579 0 0
Type I hemidesmosome assembly R-HSA-446107 2.088218e-01 0.680 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 2.088218e-01 0.680 0 0
MET receptor recycling R-HSA-8875656 2.088218e-01 0.680 0 0
MET activates RAS signaling R-HSA-8851805 1.971946e-01 0.705 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 1.971946e-01 0.705 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.971946e-01 0.705 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.971946e-01 0.705 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.971946e-01 0.705 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.971946e-01 0.705 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.971946e-01 0.705 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 2.460454e-01 0.609 0 0
ARMS-mediated activation R-HSA-170984 2.460454e-01 0.609 0 0
Calcineurin activates NFAT R-HSA-2025928 2.460454e-01 0.609 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 3.162019e-01 0.500 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 3.162019e-01 0.500 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 3.162019e-01 0.500 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 1.840949e-01 0.735 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 1.840949e-01 0.735 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 2.266666e-01 0.645 0 0
CD28 dependent Vav1 pathway R-HSA-389359 2.266666e-01 0.645 0 0
Folding of actin by CCT/TriC R-HSA-390450 2.841809e-01 0.546 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 2.086002e-01 0.681 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.086002e-01 0.681 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.922032e-01 0.716 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 1.922032e-01 0.716 0 0
GAB1 signalosome R-HSA-180292 2.340868e-01 0.631 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 2.140734e-01 0.669 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 3.227518e-01 0.491 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 3.227518e-01 0.491 0 0
Signaling by APC mutants R-HSA-4839744 3.227518e-01 0.491 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 3.227518e-01 0.491 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 3.227518e-01 0.491 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 3.227518e-01 0.491 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.964832e-01 0.707 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 2.883895e-01 0.540 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 2.883895e-01 0.540 0 0
Processive synthesis on the lagging strand R-HSA-69183 2.883895e-01 0.540 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 2.883895e-01 0.540 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.883895e-01 0.540 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.883895e-01 0.540 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 2.603850e-01 0.584 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 2.603850e-01 0.584 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 2.367456e-01 0.626 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 2.163418e-01 0.665 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 1.826108e-01 0.738 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 2.873245e-01 0.542 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 3.201057e-01 0.495 0 0
Phosphorylation of the APC/C R-HSA-176412 3.201057e-01 0.495 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 2.580301e-01 0.588 0 0
DAP12 signaling R-HSA-2424491 2.580301e-01 0.588 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 2.840328e-01 0.547 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 3.147372e-01 0.502 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 1.956891e-01 0.708 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 2.549677e-01 0.594 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 2.549677e-01 0.594 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 2.097316e-01 0.678 0 0
MET activates PTK2 signaling R-HSA-8874081 3.084129e-01 0.511 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 3.424602e-01 0.465 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.041656e-01 0.690 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 2.645676e-01 0.577 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 3.331282e-01 0.477 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 2.136106e-01 0.670 0 0
Regulation of PTEN stability and activity R-HSA-8948751 2.593887e-01 0.586 0 0
Meiotic synapsis R-HSA-1221632 2.593887e-01 0.586 0 0
HDACs deacetylate histones R-HSA-3214815 2.926509e-01 0.534 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 3.097110e-01 0.509 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 3.444963e-01 0.463 0 0
HCMV Early Events R-HSA-9609690 2.390286e-01 0.622 0 0
Ub-specific processing proteases R-HSA-5689880 3.336955e-01 0.477 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 3.039381e-01 0.517 0 0
Downstream TCR signaling R-HSA-202424 2.547452e-01 0.594 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 2.591295e-01 0.586 0 0
DNA Damage Bypass R-HSA-73893 1.973215e-01 0.705 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 2.580301e-01 0.588 0 0
Regulation of necroptotic cell death R-HSA-5675482 3.242085e-01 0.489 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.333744e-01 0.632 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 1.964832e-01 0.707 0 0
G0 and Early G1 R-HSA-1538133 1.808659e-01 0.743 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 3.201057e-01 0.495 0 0
Killing mechanisms R-HSA-9664420 3.201057e-01 0.495 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 3.084129e-01 0.511 0 0
G1 Phase R-HSA-69236 2.143058e-01 0.669 0 0
Cyclin D associated events in G1 R-HSA-69231 2.143058e-01 0.669 0 0
Processing of DNA double-strand break ends R-HSA-5693607 2.943581e-01 0.531 0 0
DNA Double Strand Break Response R-HSA-5693606 1.915090e-01 0.718 0 0
DNA strand elongation R-HSA-69190 1.808659e-01 0.743 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.097316e-01 0.678 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.140734e-01 0.669 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 2.070293e-01 0.684 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 2.442559e-01 0.612 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 3.466626e-01 0.460 0 0
Pexophagy R-HSA-9664873 2.841809e-01 0.546 0 0
Resolution of D-Loop Structures R-HSA-5693537 2.167145e-01 0.664 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.829299e-01 0.738 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 3.331282e-01 0.477 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 2.841809e-01 0.546 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 1.984592e-01 0.702 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 3.242085e-01 0.489 0 0
Signaling by Nuclear Receptors R-HSA-9006931 2.095331e-01 0.679 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.884056e-01 0.725 0 0
Signaling by PDGF R-HSA-186797 2.070293e-01 0.684 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 2.115401e-01 0.675 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 2.638527e-01 0.579 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 2.460454e-01 0.609 0 0
Regulation of Apoptosis R-HSA-169911 2.549677e-01 0.594 0 0
Regulation of RAS by GAPs R-HSA-5658442 2.121947e-01 0.673 0 0
Cellular response to starvation R-HSA-9711097 3.073445e-01 0.512 0 0
Leishmania phagocytosis R-HSA-9664417 2.492017e-01 0.603 0 0
Parasite infection R-HSA-9664407 2.492017e-01 0.603 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 2.492017e-01 0.603 0 0
Interleukin-9 signaling R-HSA-8985947 2.088218e-01 0.680 0 0
DNA Replication R-HSA-69306 3.249674e-01 0.488 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 2.638527e-01 0.579 0 0
Interleukin-23 signaling R-HSA-9020933 2.088218e-01 0.680 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 2.088218e-01 0.680 0 0
VLDLR internalisation and degradation R-HSA-8866427 1.971946e-01 0.705 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 1.971946e-01 0.705 0 0
p75NTR regulates axonogenesis R-HSA-193697 2.460454e-01 0.609 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 1.840949e-01 0.735 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 2.883895e-01 0.540 0 0
Trafficking of AMPA receptors R-HSA-399719 2.796906e-01 0.553 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 2.275189e-01 0.643 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 2.241925e-01 0.649 0 0
Signaling by WNT R-HSA-195721 2.635300e-01 0.579 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.496104e-01 0.603 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 2.266666e-01 0.645 0 0
Interleukin-1 signaling R-HSA-9020702 2.556661e-01 0.592 1 0
Interleukin-6 family signaling R-HSA-6783589 2.601045e-01 0.585 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 3.201057e-01 0.495 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.987688e-01 0.702 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 2.112095e-01 0.675 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 2.638527e-01 0.579 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 2.088218e-01 0.680 0 0
TRAIL signaling R-HSA-75158 3.162019e-01 0.500 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 1.840949e-01 0.735 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 2.571560e-01 0.590 0 0
Platelet sensitization by LDL R-HSA-432142 2.340868e-01 0.631 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 2.333744e-01 0.632 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 2.305589e-01 0.637 0 0
Nuclear RNA decay R-HSA-9930044 3.242085e-01 0.489 0 0
Effects of PIP2 hydrolysis R-HSA-114508 3.468913e-01 0.460 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 2.856552e-01 0.544 0 0
Circadian clock R-HSA-9909396 2.249877e-01 0.648 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 2.305589e-01 0.637 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 2.638527e-01 0.579 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 2.571560e-01 0.590 1 1
Formation of paraxial mesoderm R-HSA-9793380 2.856552e-01 0.544 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 1.984795e-01 0.702 0 0
Signaling by LTK R-HSA-9842663 1.971946e-01 0.705 0 0
Signaling by Activin R-HSA-1502540 2.883895e-01 0.540 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 2.355718e-01 0.628 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 3.157230e-01 0.501 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 3.364825e-01 0.473 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 2.738719e-01 0.562 0 0
Somitogenesis R-HSA-9824272 3.466626e-01 0.460 0 0
Rap1 signalling R-HSA-392517 2.603850e-01 0.584 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 3.242085e-01 0.489 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 3.366037e-01 0.473 0 0
PLC beta mediated events R-HSA-112043 2.856552e-01 0.544 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 3.084129e-01 0.511 0 0
NCAM signaling for neurite out-growth R-HSA-375165 2.070293e-01 0.684 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.483093e-01 0.605 0 0
Inhibition of PKR R-HSA-169131 2.483093e-01 0.605 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.115401e-01 0.675 0 0
Manipulation of host energy metabolism R-HSA-9636667 3.482921e-01 0.458 0 0
Reelin signalling pathway R-HSA-8866376 2.638527e-01 0.579 0 0
RSK activation R-HSA-444257 2.088218e-01 0.680 0 0
Cellular response to mitochondrial stress R-HSA-9840373 2.460454e-01 0.609 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 2.460454e-01 0.609 0 0
Bicarbonate transporters R-HSA-425381 3.227518e-01 0.491 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.964832e-01 0.707 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.601045e-01 0.585 0 0
Neurodegenerative Diseases R-HSA-8863678 2.601045e-01 0.585 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 1.820899e-01 0.740 0 0
DAG and IP3 signaling R-HSA-1489509 2.306228e-01 0.637 0 0
Hemostasis R-HSA-109582 2.032794e-01 0.692 0 0
Early Phase of HIV Life Cycle R-HSA-162594 3.147372e-01 0.502 0 0
Ca-dependent events R-HSA-111996 2.885350e-01 0.540 0 0
Hedgehog 'off' state R-HSA-5610787 2.439302e-01 0.613 0 0
Interleukin-27 signaling R-HSA-9020956 2.841809e-01 0.546 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 3.017732e-01 0.520 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 2.460454e-01 0.609 0 0
Suppression of apoptosis R-HSA-9635465 3.227518e-01 0.491 0 0
Signal regulatory protein family interactions R-HSA-391160 2.571560e-01 0.590 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 3.227518e-01 0.491 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.840358e-01 0.735 0 0
Vpu mediated degradation of CD4 R-HSA-180534 3.468913e-01 0.460 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.340868e-01 0.631 0 0
PTK6 Activates STAT3 R-HSA-8849474 2.638527e-01 0.579 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.242085e-01 0.489 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 2.758641e-01 0.559 0 0
Glycolysis R-HSA-70171 2.439302e-01 0.613 0 0
Gene Silencing by RNA R-HSA-211000 1.925075e-01 0.716 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 2.432616e-01 0.614 1 0
NrCAM interactions R-HSA-447038 2.638527e-01 0.579 0 0
XBP1(S) activates chaperone genes R-HSA-381038 2.064492e-01 0.685 0 0
IRE1alpha activates chaperones R-HSA-381070 2.029011e-01 0.693 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 3.520581e-01 0.453 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 3.520581e-01 0.453 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 3.520581e-01 0.453 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 3.520581e-01 0.453 0 0
Synthesis of PG R-HSA-1483148 3.520581e-01 0.453 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 3.574596e-01 0.447 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 3.576850e-01 0.446 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 3.613356e-01 0.442 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 3.613356e-01 0.442 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 3.613356e-01 0.442 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 3.613356e-01 0.442 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 3.613356e-01 0.442 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 3.613356e-01 0.442 0 0
NF-kB is activated and signals survival R-HSA-209560 3.613356e-01 0.442 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 3.613356e-01 0.442 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 3.613356e-01 0.442 0 0
Signaling by AXIN mutants R-HSA-4839735 3.613356e-01 0.442 0 0
Signaling by AMER1 mutants R-HSA-4839748 3.613356e-01 0.442 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 3.621433e-01 0.441 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 3.664403e-01 0.436 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 3.675734e-01 0.435 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 3.676531e-01 0.435 0 0
STAT5 Activation R-HSA-9645135 3.676531e-01 0.435 0 0
G2/M DNA replication checkpoint R-HSA-69478 3.676531e-01 0.435 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 3.676531e-01 0.435 0 0
CREB phosphorylation R-HSA-199920 3.676531e-01 0.435 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 3.676531e-01 0.435 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 3.697422e-01 0.432 0 0
Dual Incision in GG-NER R-HSA-5696400 3.697422e-01 0.432 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 3.697422e-01 0.432 0 0
Mitophagy R-HSA-5205647 3.697422e-01 0.432 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 3.697422e-01 0.432 0 0
Immune System R-HSA-168256 3.701077e-01 0.432 1 0
PI-3K cascade:FGFR1 R-HSA-5654689 3.703373e-01 0.431 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 3.703373e-01 0.431 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 3.703373e-01 0.431 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 3.703373e-01 0.431 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 3.789001e-01 0.421 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 3.789001e-01 0.421 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 3.789001e-01 0.421 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 3.789001e-01 0.421 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 3.789001e-01 0.421 0 0
mRNA Capping R-HSA-72086 3.831121e-01 0.417 0 0
Termination of translesion DNA synthesis R-HSA-5656169 3.831121e-01 0.417 0 0
Late endosomal microautophagy R-HSA-9615710 3.831121e-01 0.417 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 3.831121e-01 0.417 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 3.840190e-01 0.416 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 3.840190e-01 0.416 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 3.840190e-01 0.416 0 0
Specification of primordial germ cells R-HSA-9827857 3.840190e-01 0.416 0 0
G-protein mediated events R-HSA-112040 3.852402e-01 0.414 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 3.863278e-01 0.413 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 3.926784e-01 0.406 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 3.926784e-01 0.406 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 3.982212e-01 0.400 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 3.982212e-01 0.400 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 3.982212e-01 0.400 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 3.995656e-01 0.398 0 0
Leading Strand Synthesis R-HSA-69109 3.995656e-01 0.398 0 0
Polymerase switching R-HSA-69091 3.995656e-01 0.398 0 0
GRB2 events in EGFR signaling R-HSA-179812 3.995656e-01 0.398 0 0
Scavenging by Class F Receptors R-HSA-3000484 3.995656e-01 0.398 0 0
Interleukin-35 Signalling R-HSA-8984722 3.995656e-01 0.398 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 3.995656e-01 0.398 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 3.995656e-01 0.398 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 3.995656e-01 0.398 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 4.001833e-01 0.398 0 0
Degradation of CRY and PER proteins R-HSA-9932298 4.001833e-01 0.398 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 4.001833e-01 0.398 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 4.001833e-01 0.398 0 0
Intraflagellar transport R-HSA-5620924 4.062716e-01 0.391 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 4.097144e-01 0.388 0 0
Signaling by NOTCH3 R-HSA-9012852 4.113373e-01 0.386 0 0
Mitochondrial biogenesis R-HSA-1592230 4.114659e-01 0.386 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 4.156197e-01 0.381 0 0
Calmodulin induced events R-HSA-111933 4.156197e-01 0.381 0 0
CaM pathway R-HSA-111997 4.156197e-01 0.381 0 0
Heme signaling R-HSA-9707616 4.156364e-01 0.381 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 4.156364e-01 0.381 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 4.157811e-01 0.381 0 0
Mismatch Repair R-HSA-5358508 4.157811e-01 0.381 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 4.157811e-01 0.381 0 0
Tie2 Signaling R-HSA-210993 4.157811e-01 0.381 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 4.175193e-01 0.379 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 4.175193e-01 0.379 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 4.175193e-01 0.379 0 0
TRIF-mediated programmed cell death R-HSA-2562578 4.175193e-01 0.379 0 0
DAG1 core M1 glycosylations R-HSA-8932506 4.175193e-01 0.379 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 4.175193e-01 0.379 0 0
Disinhibition of SNARE formation R-HSA-114516 4.175193e-01 0.379 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 4.175193e-01 0.379 0 0
Recycling of eIF2:GDP R-HSA-72731 4.175193e-01 0.379 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 4.175193e-01 0.379 0 0
MECP2 regulates transcription factors R-HSA-9022707 4.175193e-01 0.379 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 4.175193e-01 0.379 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 4.175193e-01 0.379 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 4.214712e-01 0.375 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 4.259746e-01 0.371 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 4.262197e-01 0.370 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 4.323554e-01 0.364 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 4.331250e-01 0.363 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 4.331250e-01 0.363 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 4.349812e-01 0.362 0 0
NTF3 activates NTRK3 signaling R-HSA-9034013 4.349812e-01 0.362 0 0
Signaling by RAS GAP mutants R-HSA-9753510 4.349812e-01 0.362 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 4.349812e-01 0.362 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 4.349812e-01 0.362 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 4.349812e-01 0.362 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 4.349812e-01 0.362 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 4.349812e-01 0.362 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 4.349812e-01 0.362 0 0
Glycogen storage disease type IV (GBE1) R-HSA-3878781 4.349812e-01 0.362 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 4.349812e-01 0.362 0 0
mRNA Editing: A to I Conversion R-HSA-75064 4.349812e-01 0.362 0 0
The AIM2 inflammasome R-HSA-844615 4.349812e-01 0.362 0 0
C6 deamination of adenosine R-HSA-75102 4.349812e-01 0.362 0 0
Regulation of cortical dendrite branching R-HSA-8985801 4.349812e-01 0.362 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 4.349812e-01 0.362 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 4.349812e-01 0.362 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 4.364167e-01 0.360 0 0
FGFR3 mutant receptor activation R-HSA-2033514 4.371297e-01 0.359 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 4.371297e-01 0.359 0 0
Formation of axial mesoderm R-HSA-9796292 4.371297e-01 0.359 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 4.371297e-01 0.359 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 4.371297e-01 0.359 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 4.371297e-01 0.359 0 0
Degradation of AXIN R-HSA-4641257 4.384900e-01 0.358 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 4.411731e-01 0.355 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 4.427030e-01 0.354 0 0
PI Metabolism R-HSA-1483255 4.465622e-01 0.350 0 0
E2F mediated regulation of DNA replication R-HSA-113510 4.471588e-01 0.350 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 4.471588e-01 0.350 0 0
Translesion Synthesis by POLH R-HSA-110320 4.471588e-01 0.350 0 0
STING mediated induction of host immune responses R-HSA-1834941 4.471588e-01 0.350 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 4.471588e-01 0.350 0 0
The NLRP3 inflammasome R-HSA-844456 4.471588e-01 0.350 0 0
Toll-like Receptor Cascades R-HSA-168898 4.493319e-01 0.347 1 0
FRS-mediated FGFR1 signaling R-HSA-5654693 4.534710e-01 0.343 0 0
Signaling by Hedgehog R-HSA-5358351 4.537961e-01 0.343 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 4.563775e-01 0.341 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 4.578486e-01 0.339 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 4.578980e-01 0.339 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 4.578980e-01 0.339 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 4.612169e-01 0.336 0 0
Muscle contraction R-HSA-397014 4.614058e-01 0.336 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 4.636590e-01 0.334 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 4.638205e-01 0.334 0 0
RMTs methylate histone arginines R-HSA-3214858 4.638205e-01 0.334 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 4.653122e-01 0.332 0 0
Regulation by c-FLIP R-HSA-3371378 4.653122e-01 0.332 0 0
Dimerization of procaspase-8 R-HSA-69416 4.653122e-01 0.332 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 4.653122e-01 0.332 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 4.653122e-01 0.332 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 4.653122e-01 0.332 0 0
DAG1 core M2 glycosylations R-HSA-8932504 4.653122e-01 0.332 0 0
phospho-PLA2 pathway R-HSA-111995 4.653122e-01 0.332 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 4.653122e-01 0.332 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 4.653122e-01 0.332 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 4.653122e-01 0.332 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 4.653122e-01 0.332 0 0
TGFBR3 PTM regulation R-HSA-9839383 4.653122e-01 0.332 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 4.653122e-01 0.332 0 0
Hedgehog ligand biogenesis R-HSA-5358346 4.659309e-01 0.332 0 0
CRMPs in Sema3A signaling R-HSA-399956 4.737686e-01 0.324 0 0
Removal of the Flap Intermediate R-HSA-69166 4.737686e-01 0.324 0 0
Retrograde neurotrophin signalling R-HSA-177504 4.737686e-01 0.324 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 4.737686e-01 0.324 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 4.737686e-01 0.324 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 4.737686e-01 0.324 0 0
NRIF signals cell death from the nucleus R-HSA-205043 4.737686e-01 0.324 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 4.737686e-01 0.324 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 4.779882e-01 0.321 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 4.779882e-01 0.321 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 4.779882e-01 0.321 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 4.779882e-01 0.321 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 4.779882e-01 0.321 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 4.779882e-01 0.321 0 0
Protein hydroxylation R-HSA-9629569 4.779882e-01 0.321 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 4.805957e-01 0.318 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 4.805957e-01 0.318 0 0
TRP channels R-HSA-3295583 4.805957e-01 0.318 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 4.823981e-01 0.317 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 4.837330e-01 0.315 0 0
Signaling by ALK R-HSA-201556 4.837330e-01 0.315 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 4.847688e-01 0.314 0 0
Nucleosome assembly R-HSA-774815 4.847688e-01 0.314 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 4.847688e-01 0.314 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 4.847688e-01 0.314 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 4.856001e-01 0.314 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 4.904118e-01 0.309 0 0
Glucose metabolism R-HSA-70326 5.027394e-01 0.299 0 0
FOXO-mediated transcription R-HSA-9614085 5.032446e-01 0.298 0 0
Signaling by ERBB4 R-HSA-1236394 5.041339e-01 0.297 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 5.050864e-01 0.297 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 5.050864e-01 0.297 0 0
Diseases of DNA repair R-HSA-9675135 5.054963e-01 0.296 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 5.059753e-01 0.296 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 5.059753e-01 0.296 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 5.059753e-01 0.296 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 5.059753e-01 0.296 0 0
Glycogen metabolism R-HSA-8982491 5.059753e-01 0.296 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 5.072458e-01 0.295 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 5.072458e-01 0.295 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 5.072458e-01 0.295 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 5.072458e-01 0.295 0 0
Lagging Strand Synthesis R-HSA-69186 5.081275e-01 0.294 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 5.081275e-01 0.294 0 0
FGFR2 ligand binding and activation R-HSA-190241 5.081275e-01 0.294 0 0
SHC1 events in EGFR signaling R-HSA-180336 5.092715e-01 0.293 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 5.092715e-01 0.293 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 5.092715e-01 0.293 0 0
Telomere C-strand synthesis initiation R-HSA-174430 5.092715e-01 0.293 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 5.092715e-01 0.293 0 0
Protein methylation R-HSA-8876725 5.092715e-01 0.293 0 0
The NLRP1 inflammasome R-HSA-844455 5.101433e-01 0.292 0 0
PLC-gamma1 signalling R-HSA-167021 5.101433e-01 0.292 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 5.101433e-01 0.292 0 0
Invadopodia formation R-HSA-8941237 5.101433e-01 0.292 0 0
Defective HPRT1 disrupts guanine and hypoxanthine salvage R-HSA-9734281 5.101433e-01 0.292 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 5.101433e-01 0.292 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 5.101433e-01 0.292 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 5.101433e-01 0.292 0 0
FasL/ CD95L signaling R-HSA-75157 5.101433e-01 0.292 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 5.101433e-01 0.292 0 0
MET activates STAT3 R-HSA-8875791 5.101433e-01 0.292 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 5.101433e-01 0.292 0 0
Activation of BMF and translocation to mitochondria R-HSA-139910 5.101433e-01 0.292 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 5.101433e-01 0.292 0 0
Hypusine synthesis from eIF5A-lysine R-HSA-204626 5.107011e-01 0.292 0 0
CASP8 activity is inhibited R-HSA-5218900 5.107011e-01 0.292 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 5.107011e-01 0.292 0 0
Regulation of signaling by NODAL R-HSA-1433617 5.107011e-01 0.292 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 5.107011e-01 0.292 0 0
rRNA processing R-HSA-72312 5.201486e-01 0.284 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 5.302722e-01 0.276 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 5.302722e-01 0.276 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 5.333303e-01 0.273 0 0
Inflammasomes R-HSA-622312 5.333303e-01 0.273 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 5.333303e-01 0.273 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 5.372487e-01 0.270 0 0
Co-inhibition by PD-1 R-HSA-389948 5.424738e-01 0.266 0 0
Differentiation of T cells R-HSA-9945266 5.434725e-01 0.265 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 5.434725e-01 0.265 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 5.434725e-01 0.265 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 5.434725e-01 0.265 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 5.457284e-01 0.263 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 5.494129e-01 0.260 0 0
HIV Transcription Initiation R-HSA-167161 5.494129e-01 0.260 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 5.494129e-01 0.260 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 5.494129e-01 0.260 0 0
Neddylation R-HSA-8951664 5.501139e-01 0.260 0 0
Unfolded Protein Response (UPR) R-HSA-381119 5.509454e-01 0.259 0 0
Receptor Mediated Mitophagy R-HSA-8934903 5.534800e-01 0.257 0 0
2-LTR circle formation R-HSA-164843 5.534800e-01 0.257 0 0
DNA replication initiation R-HSA-68952 5.534800e-01 0.257 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 5.534800e-01 0.257 0 0
Binding and entry of HIV virion R-HSA-173107 5.534800e-01 0.257 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 5.534800e-01 0.257 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 5.534800e-01 0.257 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 5.534800e-01 0.257 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 5.534800e-01 0.257 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 5.534800e-01 0.257 0 0
Regulation of the apoptosome activity R-HSA-9627069 5.534800e-01 0.257 0 0
Formation of apoptosome R-HSA-111458 5.534800e-01 0.257 0 0
HCMV Infection R-HSA-9609646 5.563902e-01 0.255 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 5.626963e-01 0.250 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 5.658739e-01 0.247 0 0
Notch-HLH transcription pathway R-HSA-350054 5.658739e-01 0.247 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 5.658739e-01 0.247 0 0
RNA Polymerase I Transcription R-HSA-73864 5.695954e-01 0.244 0 0
Transmission across Chemical Synapses R-HSA-112315 5.741832e-01 0.241 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 5.753107e-01 0.240 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 5.753107e-01 0.240 0 0
betaKlotho-mediated ligand binding R-HSA-1307965 5.753107e-01 0.240 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 5.753107e-01 0.240 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 5.753107e-01 0.240 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 5.753107e-01 0.240 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 5.753107e-01 0.240 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 5.753107e-01 0.240 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 5.753107e-01 0.240 0 0
Regulation of gap junction activity R-HSA-191650 5.753107e-01 0.240 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 5.753107e-01 0.240 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 5.753107e-01 0.240 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 5.753107e-01 0.240 0 0
NADE modulates death signalling R-HSA-205025 5.753107e-01 0.240 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 5.753107e-01 0.240 0 0
Interleukin-38 signaling R-HSA-9007892 5.753107e-01 0.240 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 5.762459e-01 0.239 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 5.762459e-01 0.239 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 5.762459e-01 0.239 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 5.820850e-01 0.235 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 5.834977e-01 0.234 0 0
Adaptive Immune System R-HSA-1280218 5.872944e-01 0.231 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 5.911301e-01 0.228 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 5.932998e-01 0.227 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 5.935399e-01 0.227 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 5.935399e-01 0.227 0 0
Formation of the posterior neural plate R-HSA-9832991 5.935399e-01 0.227 0 0
FGFR2b ligand binding and activation R-HSA-190377 5.935399e-01 0.227 0 0
Ionotropic activity of kainate receptors R-HSA-451306 5.935399e-01 0.227 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 5.935399e-01 0.227 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 5.935399e-01 0.227 0 0
FCERI mediated MAPK activation R-HSA-2871796 5.981994e-01 0.223 1 1
Dual incision in TC-NER R-HSA-6782135 5.984532e-01 0.223 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 6.009989e-01 0.221 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 6.075016e-01 0.216 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 6.075016e-01 0.216 0 0
Glycogen storage diseases R-HSA-3229121 6.075016e-01 0.216 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 6.075016e-01 0.216 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 6.075016e-01 0.216 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 6.103508e-01 0.214 0 0
DAP12 interactions R-HSA-2172127 6.112415e-01 0.214 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 6.196704e-01 0.208 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 6.196704e-01 0.208 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 6.228046e-01 0.206 0 0
Diseases of programmed cell death R-HSA-9645723 6.264306e-01 0.203 0 0
Signaling by WNT in cancer R-HSA-4791275 6.306007e-01 0.200 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 6.308106e-01 0.200 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 6.308473e-01 0.200 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 6.308473e-01 0.200 0 0
ERKs are inactivated R-HSA-202670 6.308473e-01 0.200 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 6.308473e-01 0.200 0 0
Integration of provirus R-HSA-162592 6.308473e-01 0.200 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 6.308473e-01 0.200 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 6.308473e-01 0.200 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 6.308473e-01 0.200 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 6.308473e-01 0.200 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 6.308473e-01 0.200 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 6.318120e-01 0.199 0 0
FGFR1c and Klotho ligand binding and activation R-HSA-190374 6.318120e-01 0.199 0 0
NTRK2 activates RAC1 R-HSA-9032759 6.318120e-01 0.199 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 6.318120e-01 0.199 0 0
Defective F9 activation R-HSA-9673221 6.318120e-01 0.199 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 6.318120e-01 0.199 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 6.318120e-01 0.199 0 0
Co-inhibition by BTLA R-HSA-9927353 6.318120e-01 0.199 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 6.318120e-01 0.199 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 6.371808e-01 0.196 0 0
Activated point mutants of FGFR2 R-HSA-2033519 6.371808e-01 0.196 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.371808e-01 0.196 0 0
Presynaptic function of Kainate receptors R-HSA-500657 6.371808e-01 0.196 0 0
Leishmania infection R-HSA-9658195 6.393248e-01 0.194 0 0
Parasitic Infection Pathways R-HSA-9824443 6.393248e-01 0.194 0 0
Plasma lipoprotein clearance R-HSA-8964043 6.405846e-01 0.193 0 0
Regulated Necrosis R-HSA-5218859 6.429968e-01 0.192 0 0
Tight junction interactions R-HSA-420029 6.449389e-01 0.190 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 6.449389e-01 0.190 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 6.449389e-01 0.190 0 0
Laminin interactions R-HSA-3000157 6.449389e-01 0.190 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 6.449389e-01 0.190 0 0
Chromosome Maintenance R-HSA-73886 6.450168e-01 0.190 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 6.474455e-01 0.189 0 0
Neuronal System R-HSA-112316 6.491482e-01 0.188 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 6.498104e-01 0.187 0 0
Cellular response to chemical stress R-HSA-9711123 6.509315e-01 0.186 0 0
Signaling by NOTCH1 R-HSA-1980143 6.519873e-01 0.186 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 6.606914e-01 0.180 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 6.652514e-01 0.177 0 0
Other interleukin signaling R-HSA-449836 6.652514e-01 0.177 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 6.652514e-01 0.177 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 6.654254e-01 0.177 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 6.654254e-01 0.177 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 6.654254e-01 0.177 0 0
IRAK1 recruits IKK complex R-HSA-937039 6.654254e-01 0.177 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 6.654254e-01 0.177 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 6.654254e-01 0.177 0 0
OAS antiviral response R-HSA-8983711 6.654254e-01 0.177 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 6.682187e-01 0.175 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 6.686087e-01 0.175 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 6.690731e-01 0.175 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 6.690731e-01 0.175 0 0
Opioid Signalling R-HSA-111885 6.704616e-01 0.174 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 6.740933e-01 0.171 0 0
Meiosis R-HSA-1500620 6.744564e-01 0.171 0 0
Gastrulation R-HSA-9758941 6.750430e-01 0.171 0 0
Selenoamino acid metabolism R-HSA-2408522 6.783340e-01 0.169 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 6.807990e-01 0.167 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 6.807990e-01 0.167 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 6.807990e-01 0.167 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 6.807990e-01 0.167 0 0
Phosphorylation of Emi1 R-HSA-176417 6.807990e-01 0.167 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.807990e-01 0.167 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.807990e-01 0.167 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 6.807990e-01 0.167 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 6.807990e-01 0.167 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 6.807990e-01 0.167 0 0
Signaling by RNF43 mutants R-HSA-5340588 6.807990e-01 0.167 0 0
Signaling by MAPK mutants R-HSA-9652817 6.807990e-01 0.167 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 6.807990e-01 0.167 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 6.807990e-01 0.167 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 6.807990e-01 0.167 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 6.807990e-01 0.167 0 0
Signaling by MST1 R-HSA-8852405 6.807990e-01 0.167 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.807990e-01 0.167 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 6.807990e-01 0.167 0 0
PDE3B signalling R-HSA-165160 6.807990e-01 0.167 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 6.807990e-01 0.167 0 0
PKB-mediated events R-HSA-109703 6.807990e-01 0.167 0 0
Synthesis of PS R-HSA-1483101 6.807990e-01 0.167 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 6.807990e-01 0.167 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.807990e-01 0.167 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 6.807990e-01 0.167 0 0
VEGF ligand-receptor interactions R-HSA-194313 6.807990e-01 0.167 0 0
Maturation of protein E R-HSA-9683683 6.807990e-01 0.167 0 0
Maturation of protein E R-HSA-9694493 6.807990e-01 0.167 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 6.807990e-01 0.167 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 6.807990e-01 0.167 0 0
Integrin cell surface interactions R-HSA-216083 6.813089e-01 0.167 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 6.823783e-01 0.166 0 0
Hedgehog 'on' state R-HSA-5632684 6.890258e-01 0.162 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 6.917043e-01 0.160 0 0
Glycogen synthesis R-HSA-3322077 6.917043e-01 0.160 0 0
Packaging Of Telomere Ends R-HSA-171306 6.920540e-01 0.160 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 6.920540e-01 0.160 0 0
Signaling by NOTCH2 R-HSA-1980145 6.948303e-01 0.158 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 6.954070e-01 0.158 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 6.973400e-01 0.157 0 0
FGFR2c ligand binding and activation R-HSA-190375 6.973400e-01 0.157 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 6.973400e-01 0.157 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 6.973400e-01 0.157 0 0
Maturation of nucleoprotein R-HSA-9683610 6.973400e-01 0.157 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 6.973400e-01 0.157 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 7.035336e-01 0.153 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 7.091179e-01 0.149 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 7.165495e-01 0.145 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.165495e-01 0.145 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 7.166465e-01 0.145 0 0
Depyrimidination R-HSA-73928 7.166465e-01 0.145 0 0
Ca2+ pathway R-HSA-4086398 7.176085e-01 0.144 0 0
Signaling by NOTCH R-HSA-157118 7.187350e-01 0.143 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 7.224347e-01 0.141 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 7.232708e-01 0.141 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 7.232708e-01 0.141 0 0
Autointegration results in viral DNA circles R-HSA-177539 7.232708e-01 0.141 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 7.232708e-01 0.141 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 7.232708e-01 0.141 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 7.232708e-01 0.141 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 7.232708e-01 0.141 0 0
MET Receptor Activation R-HSA-6806942 7.232708e-01 0.141 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 7.232708e-01 0.141 0 0
VLDL assembly R-HSA-8866423 7.232708e-01 0.141 0 0
HDL clearance R-HSA-8964011 7.232708e-01 0.141 0 0
Neurofascin interactions R-HSA-447043 7.232708e-01 0.141 0 0
Prolactin receptor signaling R-HSA-1170546 7.266877e-01 0.139 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 7.266877e-01 0.139 0 0
Physiological factors R-HSA-5578768 7.266877e-01 0.139 0 0
Malate-aspartate shuttle R-HSA-9856872 7.266877e-01 0.139 0 0
Zinc transporters R-HSA-435354 7.266877e-01 0.139 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 7.318863e-01 0.136 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 7.331475e-01 0.135 0 0
Regulation of beta-cell development R-HSA-186712 7.381905e-01 0.132 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 7.398126e-01 0.131 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 7.444372e-01 0.128 0 0
Proteasome assembly R-HSA-9907900 7.502181e-01 0.125 0 0
Base Excision Repair R-HSA-73884 7.513949e-01 0.124 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 7.524902e-01 0.123 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 7.524902e-01 0.123 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 7.524902e-01 0.123 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 7.524902e-01 0.123 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 7.524902e-01 0.123 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 7.535864e-01 0.123 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 7.535864e-01 0.123 0 0
Translesion synthesis by REV1 R-HSA-110312 7.535864e-01 0.123 0 0
FGFR3 ligand binding and activation R-HSA-190239 7.535864e-01 0.123 0 0
Formation of the anterior neural plate R-HSA-9823739 7.535864e-01 0.123 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 7.540552e-01 0.123 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 7.600936e-01 0.119 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 7.600936e-01 0.119 0 0
FGFR3b ligand binding and activation R-HSA-190371 7.600936e-01 0.119 0 0
PTK6 Expression R-HSA-8849473 7.600936e-01 0.119 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 7.600936e-01 0.119 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 7.600936e-01 0.119 0 0
VLDL clearance R-HSA-8964046 7.600936e-01 0.119 0 0
Ca2+ activated K+ channels R-HSA-1296052 7.600936e-01 0.119 0 0
LDL remodeling R-HSA-8964041 7.600936e-01 0.119 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 7.600936e-01 0.119 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 7.615323e-01 0.118 0 0
LDL clearance R-HSA-8964038 7.615323e-01 0.118 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 7.629354e-01 0.118 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 7.678403e-01 0.115 0 0
Budding and maturation of HIV virion R-HSA-162588 7.724469e-01 0.112 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 7.781681e-01 0.109 0 0
Translesion synthesis by POLI R-HSA-5656121 7.781681e-01 0.109 0 0
Attachment and Entry R-HSA-9678110 7.781681e-01 0.109 0 0
Activation of SMO R-HSA-5635838 7.781681e-01 0.109 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 7.781681e-01 0.109 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 7.817570e-01 0.107 0 0
Formation of the ureteric bud R-HSA-9830674 7.817570e-01 0.107 0 0
Carnitine shuttle R-HSA-200425 7.817570e-01 0.107 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 7.838505e-01 0.106 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 7.897384e-01 0.103 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 7.920185e-01 0.101 0 0
FGFR1b ligand binding and activation R-HSA-190370 7.920185e-01 0.101 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 7.920185e-01 0.101 0 0
Activation of RAS in B cells R-HSA-1169092 7.920185e-01 0.101 0 0
Co-stimulation by ICOS R-HSA-9927354 7.920185e-01 0.101 0 0
Nucleotide salvage defects R-HSA-9734207 7.920185e-01 0.101 0 0
Sodium/Proton exchangers R-HSA-425986 7.920185e-01 0.101 0 0
Modulation by Mtb of host immune system R-HSA-9637628 7.920185e-01 0.101 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 7.920839e-01 0.101 0 0
G alpha (z) signalling events R-HSA-418597 7.928878e-01 0.101 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 7.953214e-01 0.099 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 8.005433e-01 0.097 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 8.005433e-01 0.097 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 8.005433e-01 0.097 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.005433e-01 0.097 0 0
Translesion synthesis by POLK R-HSA-5655862 8.005732e-01 0.097 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 8.005732e-01 0.097 0 0
Fibronectin matrix formation R-HSA-1566977 8.005732e-01 0.097 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 8.005732e-01 0.097 0 0
Disorders of Developmental Biology R-HSA-9675151 8.005732e-01 0.097 0 0
Passive transport by Aquaporins R-HSA-432047 8.005732e-01 0.097 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 8.005732e-01 0.097 0 0
Translation R-HSA-72766 8.009431e-01 0.096 0 0
Infectious disease R-HSA-5663205 8.064791e-01 0.093 1 0
NGF-stimulated transcription R-HSA-9031628 8.084677e-01 0.092 0 0
Synthesis of PA R-HSA-1483166 8.177579e-01 0.087 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.179531e-01 0.087 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 8.179531e-01 0.087 0 0
HDMs demethylate histones R-HSA-3214842 8.179531e-01 0.087 0 0
Formation of the nephric duct R-HSA-9830364 8.179531e-01 0.087 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 8.196966e-01 0.086 0 0
mRNA Editing R-HSA-75072 8.196966e-01 0.086 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 8.196966e-01 0.086 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 8.196966e-01 0.086 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 8.196966e-01 0.086 0 0
Interleukin-1 processing R-HSA-448706 8.196966e-01 0.086 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 8.196966e-01 0.086 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 8.196966e-01 0.086 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 8.209454e-01 0.086 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 8.209454e-01 0.086 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 8.209454e-01 0.086 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 8.209454e-01 0.086 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 8.211489e-01 0.086 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 8.211489e-01 0.086 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.211489e-01 0.086 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 8.292902e-01 0.081 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.292902e-01 0.081 0 0
Metalloprotease DUBs R-HSA-5689901 8.340524e-01 0.079 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 8.340524e-01 0.079 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 8.342659e-01 0.079 0 0
Protein ubiquitination R-HSA-8852135 8.352103e-01 0.078 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 8.394289e-01 0.076 0 0
FGFR1 ligand binding and activation R-HSA-190242 8.394289e-01 0.076 0 0
Apoptotic factor-mediated response R-HSA-111471 8.394289e-01 0.076 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 8.394289e-01 0.076 0 0
Extension of Telomeres R-HSA-180786 8.402387e-01 0.076 0 0
Telomere Maintenance R-HSA-157579 8.419717e-01 0.075 0 0
Formation of intermediate mesoderm R-HSA-9761174 8.436927e-01 0.074 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 8.436927e-01 0.074 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.436927e-01 0.074 0 0
PERK regulates gene expression R-HSA-381042 8.485797e-01 0.071 0 0
Cristae formation R-HSA-8949613 8.489098e-01 0.071 0 0
Insulin processing R-HSA-264876 8.489098e-01 0.071 0 0
Response of Mtb to phagocytosis R-HSA-9637690 8.513142e-01 0.070 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 8.539943e-01 0.069 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 8.555229e-01 0.068 0 0
Germ layer formation at gastrulation R-HSA-9754189 8.561656e-01 0.067 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 8.561656e-01 0.067 0 0
Diseases of hemostasis R-HSA-9671793 8.561656e-01 0.067 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 8.561656e-01 0.067 0 0
Maturation of nucleoprotein R-HSA-9694631 8.561656e-01 0.067 0 0
Pyroptosis R-HSA-5620971 8.625950e-01 0.064 0 0
DAG1 core M3 glycosylations R-HSA-8932505 8.644965e-01 0.063 0 0
LGI-ADAM interactions R-HSA-5682910 8.644965e-01 0.063 0 0
vRNA Synthesis R-HSA-192814 8.644965e-01 0.063 0 0
vRNP Assembly R-HSA-192905 8.644965e-01 0.063 0 0
Chylomicron assembly R-HSA-8963888 8.644965e-01 0.063 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 8.644965e-01 0.063 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 8.644965e-01 0.063 0 0
Transport of RCbl within the body R-HSA-9758890 8.644965e-01 0.063 0 0
Dissolution of Fibrin Clot R-HSA-75205 8.644965e-01 0.063 0 0
ABC-family proteins mediated transport R-HSA-382556 8.657638e-01 0.063 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 8.712929e-01 0.060 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 8.712929e-01 0.060 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 8.712929e-01 0.060 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 8.723634e-01 0.059 0 0
Cleavage of the damaged purine R-HSA-110331 8.723634e-01 0.059 0 0
Collagen chain trimerization R-HSA-8948216 8.723634e-01 0.059 0 0
Fanconi Anemia Pathway R-HSA-6783310 8.729110e-01 0.059 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 8.751778e-01 0.058 0 0
Regulation of gene expression in beta cells R-HSA-210745 8.751778e-01 0.058 0 0
DARPP-32 events R-HSA-180024 8.751778e-01 0.058 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 8.752304e-01 0.058 0 0
Interferon gamma signaling R-HSA-877300 8.781983e-01 0.056 0 0
Plasmalogen biosynthesis R-HSA-75896 8.825324e-01 0.054 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 8.825324e-01 0.054 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 8.825324e-01 0.054 0 0
Anchoring fibril formation R-HSA-2214320 8.825324e-01 0.054 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.825324e-01 0.054 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.826732e-01 0.054 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.826732e-01 0.054 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.829969e-01 0.054 0 0
Depurination R-HSA-73927 8.829969e-01 0.054 0 0
Reproduction R-HSA-1474165 8.833557e-01 0.054 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 8.849427e-01 0.053 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 8.849427e-01 0.053 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 8.849427e-01 0.053 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 8.849427e-01 0.053 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 8.849427e-01 0.053 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.867276e-01 0.052 0 0
Ion transport by P-type ATPases R-HSA-936837 8.867984e-01 0.052 0 0
Adipogenesis R-HSA-9843745 8.891344e-01 0.051 0 0
ER-Phagosome pathway R-HSA-1236974 8.906221e-01 0.050 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 8.953307e-01 0.048 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 8.953307e-01 0.048 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 8.953307e-01 0.048 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 8.972401e-01 0.047 0 0
Attachment and Entry R-HSA-9694614 8.972401e-01 0.047 0 0
Assembly Of The HIV Virion R-HSA-175474 8.972401e-01 0.047 0 0
Molecules associated with elastic fibres R-HSA-2129379 8.973122e-01 0.047 0 0
Maple Syrup Urine Disease R-HSA-9865114 8.981686e-01 0.047 0 0
Repression of WNT target genes R-HSA-4641265 8.981686e-01 0.047 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.981686e-01 0.047 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 8.981686e-01 0.047 0 0
Pervasive developmental disorders R-HSA-9005895 8.981686e-01 0.047 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 8.981686e-01 0.047 0 0
Disorders of Nervous System Development R-HSA-9697154 8.981686e-01 0.047 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.981686e-01 0.047 0 0
Activation of HOX genes during differentiation R-HSA-5619507 8.990126e-01 0.046 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 8.990126e-01 0.046 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.002613e-01 0.046 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.002613e-01 0.046 0 0
Gluconeogenesis R-HSA-70263 9.002824e-01 0.046 0 0
Diseases of Immune System R-HSA-5260271 9.019679e-01 0.045 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.019679e-01 0.045 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.083034e-01 0.042 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.083034e-01 0.042 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.083034e-01 0.042 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.103926e-01 0.041 0 0
FGFR4 ligand binding and activation R-HSA-190322 9.117242e-01 0.040 0 0
FGFR1c ligand binding and activation R-HSA-190373 9.117242e-01 0.040 0 0
Processing of SMDT1 R-HSA-8949664 9.117242e-01 0.040 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 9.117242e-01 0.040 0 0
Diseases of nucleotide metabolism R-HSA-9735804 9.117242e-01 0.040 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 9.117242e-01 0.040 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.148338e-01 0.039 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 9.158477e-01 0.038 0 0
Cardiogenesis R-HSA-9733709 9.158477e-01 0.038 0 0
Intra-Golgi traffic R-HSA-6811438 9.181667e-01 0.037 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.182431e-01 0.037 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.204457e-01 0.036 0 0
Metabolism of polyamines R-HSA-351202 9.212898e-01 0.036 0 0
ABC transporter disorders R-HSA-5619084 9.222994e-01 0.035 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.232063e-01 0.035 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.234105e-01 0.035 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 9.234760e-01 0.035 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 9.234760e-01 0.035 0 0
FGFR3c ligand binding and activation R-HSA-190372 9.234760e-01 0.035 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 9.234760e-01 0.035 0 0
Hydrolysis of LPC R-HSA-1483115 9.234760e-01 0.035 0 0
cGMP effects R-HSA-418457 9.234760e-01 0.035 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.234760e-01 0.035 0 0
Acyl chain remodeling of CL R-HSA-1482798 9.234760e-01 0.035 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 9.239233e-01 0.034 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.253312e-01 0.034 0 0
Innate Immune System R-HSA-168249 9.269868e-01 0.033 1 0
Collagen degradation R-HSA-1442490 9.273129e-01 0.033 0 0
Disease R-HSA-1643685 9.292376e-01 0.032 1 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.312827e-01 0.031 0 0
Signal amplification R-HSA-392518 9.312827e-01 0.031 0 0
eNOS activation R-HSA-203615 9.312827e-01 0.031 0 0
Hyaluronan metabolism R-HSA-2142845 9.312827e-01 0.031 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.312827e-01 0.031 0 0
Defective pyroptosis R-HSA-9710421 9.319257e-01 0.031 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.336639e-01 0.030 0 0
Synthesis of 12-eicosatetraenoic acid derivatives R-HSA-2142712 9.336639e-01 0.030 0 0
Protein lipoylation R-HSA-9857492 9.336639e-01 0.030 0 0
Transport and metabolism of PAPS R-HSA-174362 9.336639e-01 0.030 0 0
Other semaphorin interactions R-HSA-416700 9.336639e-01 0.030 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 9.336639e-01 0.030 0 0
Biotin transport and metabolism R-HSA-196780 9.336639e-01 0.030 0 0
DNA Damage Reversal R-HSA-73942 9.336639e-01 0.030 0 0
Hyaluronan degradation R-HSA-2160916 9.351562e-01 0.029 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.351562e-01 0.029 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.374140e-01 0.028 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 9.381520e-01 0.028 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.390296e-01 0.027 0 0
HCMV Late Events R-HSA-9610379 9.399164e-01 0.027 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.417136e-01 0.026 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.417162e-01 0.026 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.423133e-01 0.026 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 9.424960e-01 0.026 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 9.424960e-01 0.026 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 9.424960e-01 0.026 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 9.424960e-01 0.026 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 9.424960e-01 0.026 0 0
Regulation of BACH1 activity R-HSA-9708530 9.424960e-01 0.026 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.435561e-01 0.025 0 0
PRC2 methylates histones and DNA R-HSA-212300 9.440713e-01 0.025 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 9.440713e-01 0.025 0 0
RNA Polymerase III Transcription R-HSA-74158 9.440713e-01 0.025 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.440713e-01 0.025 0 0
Glycosphingolipid transport R-HSA-9845576 9.440713e-01 0.025 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.487147e-01 0.023 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.487147e-01 0.023 0 0
Voltage gated Potassium channels R-HSA-1296072 9.496017e-01 0.022 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.496017e-01 0.022 0 0
Ion homeostasis R-HSA-5578775 9.496869e-01 0.022 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.496869e-01 0.022 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 9.501526e-01 0.022 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 9.501526e-01 0.022 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.501526e-01 0.022 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 9.501526e-01 0.022 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.515512e-01 0.022 0 0
Dectin-2 family R-HSA-5621480 9.539689e-01 0.020 0 0
Stimuli-sensing channels R-HSA-2672351 9.542521e-01 0.020 0 0
Telomere Extension By Telomerase R-HSA-171319 9.544346e-01 0.020 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.544346e-01 0.020 0 0
Pyrimidine salvage R-HSA-73614 9.544346e-01 0.020 0 0
Elastic fibre formation R-HSA-1566948 9.546186e-01 0.020 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.546186e-01 0.020 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.549976e-01 0.020 0 0
tRNA processing R-HSA-72306 9.559573e-01 0.020 0 0
FCGR activation R-HSA-2029481 9.567462e-01 0.019 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.567901e-01 0.019 0 0
Synthesis of 15-eicosatetraenoic acid derivatives R-HSA-2142770 9.567901e-01 0.019 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.567901e-01 0.019 0 0
RAS processing R-HSA-9648002 9.591651e-01 0.018 0 0
DNA methylation R-HSA-5334118 9.595409e-01 0.018 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.595409e-01 0.018 0 0
Glucagon-type ligand receptors R-HSA-420092 9.595409e-01 0.018 0 0
Platelet calcium homeostasis R-HSA-418360 9.595409e-01 0.018 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.615449e-01 0.017 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.615512e-01 0.017 0 0
PKA activation R-HSA-163615 9.625441e-01 0.017 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 9.625441e-01 0.017 0 0
PKA activation in glucagon signalling R-HSA-164378 9.625441e-01 0.017 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 9.640957e-01 0.016 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.640957e-01 0.016 0 0
Azathioprine ADME R-HSA-9748787 9.651243e-01 0.015 0 0
COPII-mediated vesicle transport R-HSA-204005 9.656253e-01 0.015 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.670043e-01 0.015 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.670043e-01 0.015 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.675322e-01 0.014 0 0
Crosslinking of collagen fibrils R-HSA-2243919 9.675322e-01 0.014 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 9.675322e-01 0.014 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.675322e-01 0.014 0 0
Specification of the neural plate border R-HSA-9834899 9.675322e-01 0.014 0 0
Pyrimidine biosynthesis R-HSA-500753 9.675322e-01 0.014 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 9.675322e-01 0.014 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.678900e-01 0.014 0 0
Cargo concentration in the ER R-HSA-5694530 9.681553e-01 0.014 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.681553e-01 0.014 0 0
Meiotic recombination R-HSA-912446 9.683915e-01 0.014 0 0
ECM proteoglycans R-HSA-3000178 9.684748e-01 0.014 0 0
Amyloid fiber formation R-HSA-977225 9.695263e-01 0.013 0 0
Translation of Structural Proteins R-HSA-9683701 9.703688e-01 0.013 0 0
Integration of energy metabolism R-HSA-163685 9.706080e-01 0.013 0 0
Mitochondrial protein import R-HSA-1268020 9.707946e-01 0.013 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 9.713712e-01 0.013 0 0
DAG1 glycosylations R-HSA-8931838 9.717707e-01 0.012 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 9.717707e-01 0.012 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.718563e-01 0.012 0 0
Creatine metabolism R-HSA-71288 9.718563e-01 0.012 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.718563e-01 0.012 0 0
Pregnenolone biosynthesis R-HSA-196108 9.718563e-01 0.012 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.734066e-01 0.012 0 0
Nucleotide biosynthesis R-HSA-8956320 9.740864e-01 0.011 0 0
G-protein activation R-HSA-202040 9.756047e-01 0.011 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 9.756047e-01 0.011 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 9.756047e-01 0.011 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.756047e-01 0.011 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.756047e-01 0.011 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.756047e-01 0.011 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.756047e-01 0.011 0 0
Iron uptake and transport R-HSA-917937 9.778328e-01 0.010 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.778496e-01 0.010 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 9.778496e-01 0.010 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.778496e-01 0.010 0 0
Heme degradation R-HSA-189483 9.778496e-01 0.010 0 0
Mitochondrial calcium ion transport R-HSA-8949215 9.788540e-01 0.009 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.788540e-01 0.009 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.788540e-01 0.009 0 0
Serine metabolism R-HSA-977347 9.788540e-01 0.009 0 0
Ribavirin ADME R-HSA-9755088 9.788540e-01 0.009 0 0
SLC transporter disorders R-HSA-5619102 9.796757e-01 0.009 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.802630e-01 0.009 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.816426e-01 0.008 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.816707e-01 0.008 0 0
Cellular hexose transport R-HSA-189200 9.816707e-01 0.008 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.817574e-01 0.008 0 0
Kidney development R-HSA-9830369 9.817574e-01 0.008 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.826516e-01 0.008 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.826516e-01 0.008 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.828463e-01 0.008 0 0
Interleukin-10 signaling R-HSA-6783783 9.830806e-01 0.007 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.834247e-01 0.007 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.839304e-01 0.007 0 0
RSV-host interactions R-HSA-9833110 9.840821e-01 0.007 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.841124e-01 0.007 0 0
Triglyceride catabolism R-HSA-163560 9.846567e-01 0.007 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.862289e-01 0.006 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.862289e-01 0.006 0 0
Complex III assembly R-HSA-9865881 9.862289e-01 0.006 0 0
GPER1 signaling R-HSA-9634597 9.862675e-01 0.006 0 0
Metal ion SLC transporters R-HSA-425410 9.862675e-01 0.006 0 0
Platelet homeostasis R-HSA-418346 9.864552e-01 0.006 0 0
Neurotransmitter release cycle R-HSA-112310 9.870460e-01 0.006 0 0
Regulation of insulin secretion R-HSA-422356 9.871939e-01 0.006 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.873081e-01 0.006 0 0
tRNA Aminoacylation R-HSA-379724 9.873081e-01 0.006 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.873081e-01 0.006 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.877222e-01 0.005 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.880636e-01 0.005 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.880636e-01 0.005 0 0
G protein gated Potassium channels R-HSA-1296059 9.880636e-01 0.005 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.880636e-01 0.005 0 0
Aquaporin-mediated transport R-HSA-445717 9.885632e-01 0.005 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.894110e-01 0.005 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.896539e-01 0.005 0 0
Urea cycle R-HSA-70635 9.896539e-01 0.005 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.896539e-01 0.005 0 0
Sphingolipid catabolism R-HSA-9845614 9.896539e-01 0.005 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.900787e-01 0.004 0 0
Extracellular matrix organization R-HSA-1474244 9.901953e-01 0.004 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.901996e-01 0.004 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.905666e-01 0.004 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 9.910324e-01 0.004 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.910324e-01 0.004 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.910324e-01 0.004 0 0
Triglyceride biosynthesis R-HSA-75109 9.910324e-01 0.004 0 0
Collagen formation R-HSA-1474290 9.917146e-01 0.004 0 0
Ion channel transport R-HSA-983712 9.918916e-01 0.004 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.921912e-01 0.003 0 0
Insulin receptor recycling R-HSA-77387 9.922274e-01 0.003 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 9.922274e-01 0.003 0 0
Phosphate bond hydrolysis by NTPDase proteins R-HSA-8850843 9.922274e-01 0.003 0 0
Iron assimilation using enterobactin R-HSA-9638334 9.922274e-01 0.003 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.927161e-01 0.003 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.927161e-01 0.003 0 0
Phospholipid metabolism R-HSA-1483257 9.929712e-01 0.003 0 0
Thyroxine biosynthesis R-HSA-209968 9.932631e-01 0.003 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.932631e-01 0.003 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.932631e-01 0.003 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.935745e-01 0.003 0 0
Paracetamol ADME R-HSA-9753281 9.937888e-01 0.003 0 0
Neurotransmitter clearance R-HSA-112311 9.941609e-01 0.003 0 0
Formation of the cornified envelope R-HSA-6809371 9.941905e-01 0.003 0 0
Interferon alpha/beta signaling R-HSA-909733 9.946034e-01 0.002 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.947609e-01 0.002 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.949391e-01 0.002 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.950044e-01 0.002 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.950044e-01 0.002 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.955971e-01 0.002 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.955971e-01 0.002 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.956136e-01 0.002 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.960650e-01 0.002 0 0
Peroxisomal protein import R-HSA-9033241 9.960890e-01 0.002 0 0
Triglyceride metabolism R-HSA-8979227 9.960890e-01 0.002 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.961207e-01 0.002 0 0
Recycling of bile acids and salts R-HSA-159418 9.961983e-01 0.002 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.964132e-01 0.002 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.964132e-01 0.002 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.967050e-01 0.001 0 0
Nucleotide salvage R-HSA-8956321 9.969035e-01 0.001 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.971442e-01 0.001 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.971442e-01 0.001 0 0
RA biosynthesis pathway R-HSA-5365859 9.971442e-01 0.001 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.971442e-01 0.001 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.971442e-01 0.001 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.975132e-01 0.001 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.975250e-01 0.001 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.975250e-01 0.001 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.976683e-01 0.001 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.979482e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.979482e-01 0.001 0 0
The phototransduction cascade R-HSA-2514856 9.979482e-01 0.001 0 0
Translation of Structural Proteins R-HSA-9694635 9.979659e-01 0.001 0 0
NCAM1 interactions R-HSA-419037 9.981409e-01 0.001 0 0
Metabolism of folate and pterines R-HSA-196757 9.981409e-01 0.001 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.982830e-01 0.001 0 0
Purine salvage R-HSA-74217 9.983888e-01 0.001 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.987898e-01 0.001 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.988346e-01 0.001 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.989347e-01 0.000 0 0
Maturation of spike protein R-HSA-9694548 9.989512e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.989970e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.990552e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.990733e-01 0.000 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.990911e-01 0.000 0 0
Heme biosynthesis R-HSA-189451 9.990911e-01 0.000 0 0
Protein localization R-HSA-9609507 9.991909e-01 0.000 0 0
Activation of GABAB receptors R-HSA-991365 9.992123e-01 0.000 0 0
GABA B receptor activation R-HSA-977444 9.992123e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.992575e-01 0.000 0 0
Potassium Channels R-HSA-1296071 9.993208e-01 0.000 0 0
Surfactant metabolism R-HSA-5683826 9.994084e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.994123e-01 0.000 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.994873e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.995456e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.995652e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.995837e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.995952e-01 0.000 0 0
Synthesis of PC R-HSA-1483191 9.996150e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.996184e-01 0.000 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.996664e-01 0.000 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.997109e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.997423e-01 0.000 0 0
PPARA activates gene expression R-HSA-1989781 9.997429e-01 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 9.997669e-01 0.000 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.997873e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.998148e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.998477e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.998665e-01 0.000 0 0
Cardiac conduction R-HSA-5576891 9.998805e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.998847e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.998939e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.998975e-01 0.000 0 0
RAB geranylgeranylation R-HSA-8873719 9.999402e-01 0.000 0 0
GABA receptor activation R-HSA-977443 9.999402e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.999402e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999466e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.999482e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999709e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999725e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.999781e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.999810e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999818e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999822e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.999844e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.999876e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.999876e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999882e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.999920e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.999930e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999952e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.999961e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999961e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999971e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999977e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999988e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999992e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999995e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999997e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999998e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999998e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999999e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999999e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999999e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999999e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999999e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
G alpha (i) signalling events R-HSA-418594 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 1 0
Visual phototransduction R-HSA-2187338 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 -0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways