MAP2K3

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Y Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Log-Odds: Y Sites / Y Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
O00165 S153 Sugiyama HAX1 HS1BP1 PDSHQPRIFGGVLESDARSEsPQPAPDWGsQRPFHRFDDVW
O14545 T323 Sugiyama TRAFD1 FLN29 ELLIDHQTSCNPSRALPsLNtGsssPRGVEEPDVIFQNFLQ
O15264 T180 GPS6|SIGNOR|EPSD|PSP MAPK13 PRKM13 SAPK4 EDCELKILDFGLARHADAEMtGyVVtRWYRAPEVILSWMHY
O15264 Y182 SIGNOR|EPSD|PSP MAPK13 PRKM13 SAPK4 CELKILDFGLARHADAEMtGyVVtRWYRAPEVILSWMHYNQ
O60361 Y136 Sugiyama NME2P1 SLRFKPEELVDYKSCAHDWVyE___________________
O60664 Y95 Sugiyama PLIN3 M6PRBP1 TIP47 VsGAQPILSKLEPQIAsAsEyAHRGLDKLEENLPILQQPTE
P00338 Y239 Sugiyama LDHA PIG19 GtDKDKEQWKEVHKQVVEsAyEVIKLKGYtSWAIGLSVADL
P00558 S415 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 GGGAsLELLEGKVLPGVDALsNI__________________
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P06733 T41 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 EVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKG
P06733 Y44 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 LFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKGVSK
P07195 S320 Sugiyama LDHB GLtsVINQKLKDDEVAQLKKsADtLWDIQKDLKDL______
P07237 Y94 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB GSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFFRNGDTASPK
P07900 S53 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDsG
P07900 Y284 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DEEEEKKDGDKKKKKKIKEKyIDQEELNKtKPIWtRNPDDI
P08238 Y276 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DEEDDsGKDKKKKTKKIKEKyIDQEELNKtKPIWtRNPDDI
P08238 Y301 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB ELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHF
P09104 Y44 Sugiyama ENO2 LyTAKGLFRAAVPsGAstGIyEALELRDGDKQRYLGKGVLK
P11142 Y41 Sugiyama HSPA8 HSC70 HSP73 HSPA10 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P13929 Y44 Sugiyama ENO3 LHtAKGRFRAAVPsGAstGIyEALELRDGDKGRYLGKGVLK
P17066 Y43 Sugiyama HSPA6 HSP70B' FQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAAL
P17812 S575 Sugiyama CTPS1 CTPS LQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD____
P18615 Y170 Sugiyama NELFE RD RDBP GEEAEGPGAGDGPPRsFDWGyEERSGAHSsAsPPRsRSRDR
P18621 S5 Sugiyama RPL17 ________________MVRysLDPENPtKsCKSRGSNLRVH
P22392 Y151 Sugiyama NME2 NM23B SLWFKPEELVDyKSCAHDWVyE___________________
P23528 Y140 Sugiyama CFL1 CFL SKDAIKKKLtGIKHELQANCyEEVKDRCTLAEKLGGsAVIs
P25398 Y127 Sugiyama RPS12 sCVVVKDYGKESQAKDVIEEyFKCKK_______________
P26038 S576 Sugiyama MSN YKtLRQIRQGNTKQRIDEFEsM___________________
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P29692 T147 Sugiyama EEF1D EF1D PQtQHVsPMRQVEPPAKKPAtPAEDDEDDDIDLFGsDNEEE
P31943 Y266 Sugiyama HNRNPH1 HNRPH HNRPH1 yNGYNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGstFQst
P34931 Y43 Sugiyama HSPA1L FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P37802 T180 Sugiyama TAGLN2 KIAA0120 CDABP0035 RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P39023 S265 Sugiyama RPL3 OK/SW-cl.32 HRGLRKVACIGAWHPARVAFsVARAGQKGYHHRTEINKKIY
P42166 T160 Sugiyama TMPO LAP2 KLYEKKLLKLREQGtEsRsstPLPtIsssAENtRQNGsNDs
P42167 T160 Sugiyama TMPO LAP2 KLYEKKLLKLREQGTESRsstPLPTISsSAENTRQNGSNDS
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46734 S218 GPS6|ELM|iPTMNet|EPSD|PSP MAP2K3 MEK3 MKK3 PRKMK3 SKK2 INKEGHVKMCDFGISGyLVDsVAKtMDAGCKPYMAPERINP
P46734 S286 Sugiyama MAP2K3 MEK3 MKK3 PRKMK3 SKK2 FPYESWGTPFQQLKQVVEEPsPQLPADRFSPEFVDFTAQCL
P46734 T222 GPS6|ELM|iPTMNet|EPSD|PSP MAP2K3 MEK3 MKK3 PRKMK3 SKK2 GHVKMCDFGISGyLVDsVAKtMDAGCKPYMAPERINPELNQ
P47712 S727 Sugiyama PLA2G4A CPLA2 PLA2G4 VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP
P48741 Y43 Sugiyama HSPA7 HSP70B FQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAAL
P53778 T183 GPS6|ELM|iPTMNet|EPSD MAPK12 ERK6 SAPK3 EDCELKILDFGLARQADsEMtGyVVtRWYRAPEVILNWMRY
P53778 Y185 ELM|iPTMNet|EPSD MAPK12 ERK6 SAPK3 CELKILDFGLARQADsEMtGyVVtRWYRAPEVILNWMRYTQ
P54652 Y42 Sugiyama HSPA2 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P55795 Y266 Sugiyama HNRNPH2 FTP3 HNRPH2 YGGYNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGssFQst
P60174 Y209 Sugiyama TPI1 TPI LRGWLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDG
P61604 Y100 Sugiyama HSPE1 KVVLDDKDyFLFRDGDILGKyVD__________________
P62191 Y439 Sugiyama PSMC1 FKKSKENVLyKKQEGtPEGLyL___________________
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P63173 T14 Sugiyama RPL38 _______MPRKIEEIKDFLLtARRKDAKSVKIKKNKDNVKF
P63220 Y53 Sugiyama RPS21 QMNVAEVDKVTGRFNGQFKtyAICGAIRRMGEsDDsILRLA
P85037 S445 Sugiyama FOXK1 MNF GLMsPRsGGLQtPECLsREGsPIPHDPEFGsKLASVPEYRY
Q00613 S363 Sugiyama HSF1 HSTF1 AsVTALtDARGHTDtEGRPPsPPPtstPEKCLsVACLDKNE
Q00839 Y260 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 GDKKRGVKRPREDHGRGyFEyIEENKysRAKsPQPPVEEED
Q01130 S212 Sugiyama SRSF2 SFRS2 PPPVsKRESKSRSRsKsPPKsPEEEGAVss___________
Q01518 T165 Sugiyama CAP1 CAP AMAPKPGPYVKEMNDAAMFytNRVLKEYKDVDKKHVDWVKA
Q06830 Y116 Sugiyama PRDX1 PAGA PAGB TDPX2 GLGPMNIPLVSDPKRtIAQDyGVLKADEGIsFRGLFIIDDK
Q13112 S410 Sugiyama CHAF1B CAF1A CAF1P60 MPHOSPH7 MPP7 LNMRtPDtAKKTKsQtHRGssPGPRPVEGtPASRtQDPssP
Q13158 S194 Sugiyama FADD MORT1 GIG3 ADLVQEVQQARDLQNRsGAMsPMsWNsDAsTSEAS______
Q13247 S303 Sugiyama SRSF6 SFRS6 SRP55 ENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsPPPKRAT
Q13283 S232 Sugiyama G3BP1 G3BP EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q14568 S53 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 IINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDSG
Q14568 Y283 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 sDEEEEKKDGDKKKKKTKEKyIDQEELNKTKPIWTRNPDDI
Q15637 S82 Sugiyama SF1 ZFM1 ZNF162 TRKLRtGDLGIPPNPEDRsPsPEPIyNsEGKRLNTREFRTR
Q15759 T180 GPS6|EPSD MAPK11 PRKM11 SAPK2 SAPK2B EDCELRILDFGLARQADEEMtGyVAtRWYRAPEIMLNWMHY
Q15759 Y182 EPSD MAPK11 PRKM11 SAPK2 SAPK2B CELRILDFGLARQADEEMtGyVAtRWYRAPEIMLNWMHYNQ
Q16539 T180 GPS6|SIGNOR|EPSD|PSP MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A EDCELKILDFGLARHtDDEMtGyVAtRWYRAPEIMLNWMHY
Q16539 Y182 SIGNOR|EPSD|PSP MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A CELKILDFGLARHtDDEMtGyVAtRWYRAPEIMLNWMHYNQ
Q58FF8 Y198 Sugiyama HSP90AB2P HSP90BB DEEDDsGKDKKKKTKKIKEKyIDQEELNKTKPIWTRNTEDI
Q6GYQ0 T1002 Sugiyama RALGAPA1 GARNL1 KIAA0884 TULIP1 TITGSESASPVHSPLGSRsQtPsPSTLNIDHMEQKDLQLDE
Q6UN15 S492 Sugiyama FIP1L1 FIP1 RHE DRDRDRERERTRERERERDHsPtPsVFNsDEERyRYREYAE
Q6UN15 S496 Sugiyama FIP1L1 FIP1 RHE DRERERTRERERERDHsPtPsVFNsDEERyRYREYAERGYE
Q6UN15 T494 Sugiyama FIP1L1 FIP1 RHE DRDRERERTRERERERDHsPtPsVFNsDEERyRYREYAERG
Q7Z2W4 T273 Sugiyama ZC3HAV1 ZC3HDC2 PRO1677 FFQGsQEFLASASAsAERsCtPsPDQIsHRAsLEDAPVDDL
Q8IWX8 S815 Sugiyama CHERP DAN26 SCAF6 RSQSRSRSKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIP
Q8IWX8 S817 Sugiyama CHERP DAN26 SCAF6 QSRSRSKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIPDS
Q8IWX8 T819 Sugiyama CHERP DAN26 SCAF6 RSRSKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIPDSRL
Q8N684 T203 Sugiyama CPSF7 GGIPPRAHsRDssDsADGRAtPsENLVPSSARVDKPPSVLP
Q8TAM6 S280 Sugiyama ERMN KIAA1189 TISYRKIRKGNTKQRIDEFEsMMHL________________
Q96CT7 Y38 Sugiyama CCDC124 RRAEAKAAADAKKQKELEDAyWKDDDKHVMRKEQRKEEKEK
Q96S44 T8 Sugiyama TP53RK C20orf64 PRPK _____________MAAARAttPADGEEPAPEAEALAAARER
Q99759 S340 Sugiyama MAP3K3 MAPKKK3 MEKK3 ENMGLAVQYLDPRGRLRsADsENALsVQERNVPTKsPsAPI
Q9BTA9 S525 Sugiyama WAC KIAA1844 QGHEPVsPRSLQRsssQRsPsPGPNHtsNssNAsNATVVPQ
Q9C0C2 S672 Sugiyama TNKS1BP1 KIAA1741 TAB182 TLARAETtQARtEAQDLCRAsPEPPGPEsSSRWLDDLLAsP
Q9H6F5 S91 Sugiyama CCDC86 CYCLON RLQQGAGLEsPQGQPEPGAAsPQRQQDLHLEsPQRQPEysP
Q9H7N4 S498 Sugiyama SCAF1 SFRS19 SRA1 GGLDLRRKILTQRRERyRQRsPsPAPAPAPAAAAGPPTRKK
Q9H7N4 S500 Sugiyama SCAF1 SFRS19 SRA1 LDLRRKILTQRRERyRQRsPsPAPAPAPAAAAGPPTRKKSR
Q9NWB6 S77 Sugiyama ARGLU1 RsRstNTAVSRRERDRERAssPPDRIDIFGRTVSKRSSLDE
Q9UQ35 S1103 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 sPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEFsA
Q9UQ35 S1648 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 APRALPRRSRSGSSSKGRGPsPEGssstEssPEHPPKSRTA
Q9UQ35 S2132 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 SRMsCFsRPsMsPtPLDRCRsPGMLEPLGssRtPMsVLQQA
Q9UQ35 S876 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 tsPQANEQsVtPQRRsCFEssPDPELKsRtPsRHsCsGssP
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 8.881784e-16 15.051 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 4.218847e-15 14.375 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.875478e-14 13.541 0 0
Cell Cycle, Mitotic R-HSA-69278 3.341771e-14 13.476 0 0
Axon guidance R-HSA-422475 2.278178e-13 12.642 0 0
Nervous system development R-HSA-9675108 3.377298e-13 12.471 0 0
Cellular response to heat stress R-HSA-3371556 1.526113e-12 11.816 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.791234e-11 10.747 0 0
M Phase R-HSA-68886 2.381217e-11 10.623 0 0
Attenuation phase R-HSA-3371568 6.038325e-11 10.219 0 0
Cellular responses to stimuli R-HSA-8953897 6.157996e-11 10.211 1 0
mRNA Splicing - Major Pathway R-HSA-72163 1.336378e-10 9.874 0 0
HSF1-dependent transactivation R-HSA-3371571 3.598531e-10 9.444 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 8.740766e-10 9.058 0 0
Signaling by ALK in cancer R-HSA-9700206 8.740766e-10 9.058 0 0
Cellular responses to stress R-HSA-2262752 9.093138e-10 9.041 1 0
mRNA Splicing R-HSA-72172 1.296016e-09 8.887 0 0
Apoptotic execution phase R-HSA-75153 1.831429e-09 8.737 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.370398e-09 8.625 0 0
Signal Transduction R-HSA-162582 2.501243e-09 8.602 0 0
Metabolism of RNA R-HSA-8953854 9.132291e-09 8.039 0 0
Apoptosis R-HSA-109581 9.920278e-09 8.003 0 0
Programmed Cell Death R-HSA-5357801 1.474903e-08 7.831 0 0
HSF1 activation R-HSA-3371511 3.030780e-08 7.518 0 0
mRNA 3'-end processing R-HSA-72187 6.975206e-08 7.156 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 7.435840e-08 7.129 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 7.869721e-08 7.104 0 0
Mitotic Anaphase R-HSA-68882 1.001051e-07 7.000 0 0
Cell Cycle Checkpoints R-HSA-69620 1.096220e-07 6.960 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.181069e-07 6.928 0 0
Chromatin organization R-HSA-4839726 1.883838e-07 6.725 0 0
Separation of Sister Chromatids R-HSA-2467813 3.128360e-07 6.505 0 0
Signaling by VEGF R-HSA-194138 3.733571e-07 6.428 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 4.896971e-07 6.310 0 0
Cell-Cell communication R-HSA-1500931 5.023334e-07 6.299 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 5.700062e-07 6.244 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 8.221686e-07 6.085 0 0
Recycling pathway of L1 R-HSA-437239 1.076446e-06 5.968 0 0
Signaling by ROBO receptors R-HSA-376176 1.097075e-06 5.960 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.419062e-06 5.848 0 0
Chromatin modifying enzymes R-HSA-3247509 1.600327e-06 5.796 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.756592e-06 5.755 0 0
Signaling by ERBB2 R-HSA-1227986 2.780458e-06 5.556 0 0
Cellular Senescence R-HSA-2559583 2.842461e-06 5.546 1 0
EPH-Ephrin signaling R-HSA-2682334 4.211529e-06 5.376 0 0
Mitotic G2-G2/M phases R-HSA-453274 5.137249e-06 5.289 0 0
Regulation of TP53 Activity R-HSA-5633007 5.201274e-06 5.284 0 0
Mitotic Prophase R-HSA-68875 5.470028e-06 5.262 0 0
G2/M Checkpoints R-HSA-69481 5.565031e-06 5.255 0 0
MAPK family signaling cascades R-HSA-5683057 6.931905e-06 5.159 0 0
G2/M Transition R-HSA-69275 7.147300e-06 5.146 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 7.474991e-06 5.126 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 7.714522e-06 5.113 0 0
Mitotic Prometaphase R-HSA-68877 1.071050e-05 4.970 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.076938e-05 4.968 0 0
L1CAM interactions R-HSA-373760 1.141506e-05 4.943 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.197144e-05 4.922 0 0
Cell junction organization R-HSA-446728 1.598126e-05 4.796 0 0
Aggrephagy R-HSA-9646399 1.725752e-05 4.763 0 0
Membrane Trafficking R-HSA-199991 1.763983e-05 4.754 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.800305e-05 4.745 0 0
Regulation of CDH1 Function R-HSA-9764561 2.216363e-05 4.654 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.391346e-05 4.621 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 2.670563e-05 4.573 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 3.187157e-05 4.497 0 0
RAF/MAP kinase cascade R-HSA-5673001 3.341123e-05 4.476 0 0
Regulation of signaling by CBL R-HSA-912631 3.448246e-05 4.462 0 0
Signaling by Interleukins R-HSA-449147 4.026819e-05 4.395 1 0
DNA Replication Pre-Initiation R-HSA-69002 4.076462e-05 4.390 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 4.325483e-05 4.364 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 4.325483e-05 4.364 0 0
Translation initiation complex formation R-HSA-72649 6.535294e-05 4.185 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 6.625348e-05 4.179 0 0
Post NMDA receptor activation events R-HSA-438064 6.757417e-05 4.170 0 0
S Phase R-HSA-69242 7.460002e-05 4.127 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 9.127553e-05 4.040 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.035569e-04 3.985 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.017287e-04 3.993 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.017287e-04 3.993 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.074331e-04 3.969 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.152388e-04 3.938 0 0
ESR-mediated signaling R-HSA-8939211 1.151415e-04 3.939 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.099173e-04 3.959 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.195815e-04 3.922 0 0
G1/S Transition R-HSA-69206 1.253903e-04 3.902 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.325494e-04 3.878 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.358002e-04 3.867 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.400358e-04 3.854 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.513771e-04 3.820 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.722328e-04 3.764 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.652998e-04 3.782 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.706400e-04 3.768 1 1
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.646609e-04 3.783 0 0
Selective autophagy R-HSA-9663891 1.744336e-04 3.758 0 0
Host Interactions of HIV factors R-HSA-162909 1.754522e-04 3.756 0 0
FLT3 Signaling R-HSA-9607240 1.795865e-04 3.746 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.807460e-04 3.743 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.835204e-04 3.736 0 0
Signaling by Hippo R-HSA-2028269 1.913814e-04 3.718 0 0
TCR signaling R-HSA-202403 1.945980e-04 3.711 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 2.264679e-04 3.645 0 0
Signaling by PTK6 R-HSA-8848021 2.264679e-04 3.645 0 0
Gene expression (Transcription) R-HSA-74160 2.295715e-04 3.639 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.368142e-04 3.626 0 0
ISG15 antiviral mechanism R-HSA-1169408 2.462268e-04 3.609 0 0
Stabilization of p53 R-HSA-69541 2.728916e-04 3.564 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 2.744728e-04 3.562 0 0
HIV Infection R-HSA-162906 2.801369e-04 3.553 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 3.014958e-04 3.521 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 3.021800e-04 3.520 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 3.150264e-04 3.502 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 3.453830e-04 3.462 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 3.375601e-04 3.472 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 3.597310e-04 3.444 0 0
Estrogen-dependent gene expression R-HSA-9018519 4.428807e-04 3.354 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 4.446091e-04 3.352 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 4.451183e-04 3.352 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 4.732696e-04 3.325 0 0
Hedgehog 'off' state R-HSA-5610787 4.764116e-04 3.322 0 0
Adherens junctions interactions R-HSA-418990 4.603552e-04 3.337 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 4.802505e-04 3.319 0 0
EPHB-mediated forward signaling R-HSA-3928662 5.037379e-04 3.298 0 0
DNA Double Strand Break Response R-HSA-5693606 5.163364e-04 3.287 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 5.387705e-04 3.269 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 5.463597e-04 3.263 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 5.728203e-04 3.242 0 0
Ribosome-associated quality control R-HSA-9948299 5.771787e-04 3.239 0 0
Epigenetic regulation of gene expression R-HSA-212165 5.819721e-04 3.235 0 0
Signaling by RAF1 mutants R-HSA-9656223 5.940472e-04 3.226 0 0
Eukaryotic Translation Initiation R-HSA-72613 6.551330e-04 3.184 0 0
Cap-dependent Translation Initiation R-HSA-72737 6.551330e-04 3.184 0 0
Cytokine Signaling in Immune system R-HSA-1280215 6.165641e-04 3.210 1 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 6.647625e-04 3.177 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 7.326359e-04 3.135 0 0
Oncogenic MAPK signaling R-HSA-6802957 7.344931e-04 3.134 0 0
Switching of origins to a post-replicative state R-HSA-69052 7.572630e-04 3.121 0 0
Signaling by RAS mutants R-HSA-6802949 8.047589e-04 3.094 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 8.047589e-04 3.094 0 0
Signaling downstream of RAS mutants R-HSA-9649948 8.047589e-04 3.094 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 8.047589e-04 3.094 0 0
Cell-cell junction organization R-HSA-421270 7.829392e-04 3.106 0 0
Regulation of RAS by GAPs R-HSA-5658442 8.427277e-04 3.074 0 0
Homology Directed Repair R-HSA-5693538 8.664321e-04 3.062 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 8.667670e-04 3.062 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 8.920068e-04 3.050 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 8.920068e-04 3.050 0 0
Interleukin-2 family signaling R-HSA-451927 8.953023e-04 3.048 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 8.953023e-04 3.048 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 9.112821e-04 3.040 0 0
Signaling by SCF-KIT R-HSA-1433557 9.570835e-04 3.019 0 0
Striated Muscle Contraction R-HSA-390522 9.598794e-04 3.018 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 9.598794e-04 3.018 0 0
Transport of connexons to the plasma membrane R-HSA-190872 9.686822e-04 3.014 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 9.714538e-04 3.013 0 0
Downstream signal transduction R-HSA-186763 1.118503e-03 2.951 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.222384e-03 2.913 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.231988e-03 2.909 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.243814e-03 2.905 0 0
Nuclear import of Rev protein R-HSA-180746 1.244509e-03 2.905 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 1.244509e-03 2.905 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 1.244522e-03 2.905 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 1.284699e-03 2.891 0 0
Orc1 removal from chromatin R-HSA-68949 1.284699e-03 2.891 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.296770e-03 2.887 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.318931e-03 2.880 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.493721e-03 2.826 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.493721e-03 2.826 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.461150e-03 2.835 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.494281e-03 2.826 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 1.541904e-03 2.812 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 1.541904e-03 2.812 0 0
Degradation of CDH1 R-HSA-9766229 1.541904e-03 2.812 0 0
Signalling to ERKs R-HSA-187687 1.597557e-03 2.797 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 1.709023e-03 2.767 0 0
Deubiquitination R-HSA-5688426 1.725552e-03 2.763 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.829689e-03 2.738 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.850620e-03 2.733 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 1.850620e-03 2.733 0 0
Integrin signaling R-HSA-354192 1.888056e-03 2.724 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.938698e-03 2.712 0 0
PTEN Regulation R-HSA-6807070 1.945769e-03 2.711 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 2.038980e-03 2.691 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 2.273939e-03 2.643 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 2.273939e-03 2.643 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 2.250113e-03 2.648 0 0
Influenza Infection R-HSA-168255 2.181158e-03 2.661 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 2.283625e-03 2.641 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.300690e-03 2.638 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 2.300690e-03 2.638 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.300690e-03 2.638 0 0
Spry regulation of FGF signaling R-HSA-1295596 2.327492e-03 2.633 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.375907e-03 2.624 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.446260e-03 2.611 0 0
SARS-CoV-1-host interactions R-HSA-9692914 2.446476e-03 2.611 0 0
PKR-mediated signaling R-HSA-9833482 2.455693e-03 2.610 0 0
Signaling by EGFR R-HSA-177929 2.782680e-03 2.556 0 0
UCH proteinases R-HSA-5689603 2.531292e-03 2.597 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 2.589556e-03 2.587 0 0
HATs acetylate histones R-HSA-3214847 2.688991e-03 2.570 0 0
Degradation of DVL R-HSA-4641258 2.559891e-03 2.592 0 0
Synthesis of DNA R-HSA-69239 2.788854e-03 2.555 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.601173e-03 2.585 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 2.760863e-03 2.559 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 2.559891e-03 2.592 0 0
Diseases of programmed cell death R-HSA-9645723 2.657199e-03 2.576 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 2.601173e-03 2.585 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 2.735938e-03 2.563 0 0
Kinesins R-HSA-983189 2.756929e-03 2.560 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 2.790280e-03 2.554 0 0
Formation of a pool of free 40S subunits R-HSA-72689 2.814181e-03 2.551 0 0
Processing of DNA double-strand break ends R-HSA-5693607 2.862441e-03 2.543 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 2.864846e-03 2.543 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 2.864846e-03 2.543 0 0
Signaling by Hedgehog R-HSA-5358351 2.903882e-03 2.537 0 0
Ephrin signaling R-HSA-3928664 2.990206e-03 2.524 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.990206e-03 2.524 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 3.010821e-03 2.521 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 3.010821e-03 2.521 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 3.053618e-03 2.515 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 3.055740e-03 2.515 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 3.057780e-03 2.515 0 0
Mitotic Spindle Checkpoint R-HSA-69618 3.076513e-03 2.512 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 3.198183e-03 2.495 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 3.292468e-03 2.482 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 3.292468e-03 2.482 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 3.360798e-03 2.474 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 3.360798e-03 2.474 0 0
Signaling by ERBB4 R-HSA-1236394 3.570959e-03 2.447 0 0
COPI-mediated anterograde transport R-HSA-6807878 3.226265e-03 2.491 0 0
Interleukin-6 signaling R-HSA-1059683 3.624875e-03 2.441 0 0
Signaling by NTRKs R-HSA-166520 3.569532e-03 2.447 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 3.685682e-03 2.433 0 0
HIV Life Cycle R-HSA-162587 3.502521e-03 2.456 0 0
Nuclear Envelope Breakdown R-HSA-2980766 3.330357e-03 2.478 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 3.347055e-03 2.475 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 3.347055e-03 2.475 0 0
DNA Replication R-HSA-69306 3.726396e-03 2.429 0 0
AURKA Activation by TPX2 R-HSA-8854518 3.791770e-03 2.421 0 0
PECAM1 interactions R-HSA-210990 3.792937e-03 2.421 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 3.886262e-03 2.410 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 3.962912e-03 2.402 0 0
Sema4D in semaphorin signaling R-HSA-400685 4.001302e-03 2.398 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 4.025734e-03 2.395 0 0
Centrosome maturation R-HSA-380287 4.160276e-03 2.381 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 4.347535e-03 2.362 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 4.569906e-03 2.340 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 4.582246e-03 2.339 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 4.582246e-03 2.339 0 0
Semaphorin interactions R-HSA-373755 4.582246e-03 2.339 0 0
Regulation of necroptotic cell death R-HSA-5675482 4.599821e-03 2.337 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 4.656721e-03 2.332 0 0
Signaling by KIT in disease R-HSA-9669938 4.701423e-03 2.328 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 4.701423e-03 2.328 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 4.701423e-03 2.328 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 4.796623e-03 2.319 0 0
HDACs deacetylate histones R-HSA-3214815 4.796623e-03 2.319 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 5.668110e-03 2.247 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 5.208288e-03 2.283 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 5.491815e-03 2.260 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 5.491815e-03 2.260 0 0
Signaling by EGFR in Cancer R-HSA-1643713 5.170279e-03 2.286 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 5.511706e-03 2.259 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 5.511706e-03 2.259 0 0
Generation of second messenger molecules R-HSA-202433 4.872065e-03 2.312 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 5.541340e-03 2.256 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 5.039758e-03 2.298 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 5.668110e-03 2.247 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 4.872065e-03 2.312 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 4.915857e-03 2.308 0 0
Autophagy R-HSA-9612973 5.049483e-03 2.297 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 5.541340e-03 2.256 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 5.019176e-03 2.299 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 5.685777e-03 2.245 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 5.685777e-03 2.245 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 5.743216e-03 2.241 0 0
Vpu mediated degradation of CD4 R-HSA-180534 5.743216e-03 2.241 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 5.780474e-03 2.238 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 5.780474e-03 2.238 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 5.780474e-03 2.238 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 5.780474e-03 2.238 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 5.780474e-03 2.238 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 5.780474e-03 2.238 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 5.780474e-03 2.238 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 5.780474e-03 2.238 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 5.780474e-03 2.238 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 5.780474e-03 2.238 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 5.780474e-03 2.238 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 5.858941e-03 2.232 0 0
Amplification of signal from the kinetochores R-HSA-141424 5.858941e-03 2.232 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 5.882277e-03 2.230 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 5.882277e-03 2.230 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 5.944944e-03 2.226 0 0
G1 Phase R-HSA-69236 5.945367e-03 2.226 0 0
Cyclin D associated events in G1 R-HSA-69231 5.945367e-03 2.226 0 0
RNA Polymerase II Transcription R-HSA-73857 6.008799e-03 2.221 0 0
Interleukin receptor SHC signaling R-HSA-912526 6.132364e-03 2.212 0 0
Uptake and function of anthrax toxins R-HSA-5210891 6.362039e-03 2.196 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 6.490816e-03 2.188 0 0
Macroautophagy R-HSA-1632852 6.508811e-03 2.186 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 6.545937e-03 2.184 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 6.598094e-03 2.181 0 0
Signaling by NOTCH4 R-HSA-9013694 6.732273e-03 2.172 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 7.280788e-03 2.138 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 7.280788e-03 2.138 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 7.887623e-03 2.103 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 7.887623e-03 2.103 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 6.914099e-03 2.160 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 6.914099e-03 2.160 0 0
Negative regulation of MAPK pathway R-HSA-5675221 7.202081e-03 2.143 0 0
MAP2K and MAPK activation R-HSA-5674135 7.202081e-03 2.143 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 7.763568e-03 2.110 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 7.144010e-03 2.146 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 7.026707e-03 2.153 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 8.045255e-03 2.094 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 7.887623e-03 2.103 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 7.202081e-03 2.143 0 0
VLDLR internalisation and degradation R-HSA-8866427 8.177354e-03 2.087 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 8.118348e-03 2.091 0 0
Gap junction trafficking and regulation R-HSA-157858 7.034621e-03 2.153 0 0
Developmental Biology R-HSA-1266738 6.881620e-03 2.162 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 7.202081e-03 2.143 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 8.209148e-03 2.086 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 8.458587e-03 2.073 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 8.458587e-03 2.073 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 8.466490e-03 2.072 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 8.516830e-03 2.070 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 8.714487e-03 2.060 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 8.714487e-03 2.060 0 0
Regulation of Apoptosis R-HSA-169911 8.714487e-03 2.060 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 8.732710e-03 2.059 0 0
Josephin domain DUBs R-HSA-5689877 8.906722e-03 2.050 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 9.183113e-03 2.037 0 0
Regulation of PTEN localization R-HSA-8948747 9.183113e-03 2.037 0 0
Metabolism of non-coding RNA R-HSA-194441 9.196927e-03 2.036 0 0
snRNP Assembly R-HSA-191859 9.196927e-03 2.036 0 0
Eukaryotic Translation Elongation R-HSA-156842 9.285853e-03 2.032 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 9.409863e-03 2.026 1 1
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.534265e-03 2.021 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.847679e-03 2.007 0 0
Prolonged ERK activation events R-HSA-169893 9.930872e-03 2.003 0 0
Signaling by FGFR4 R-HSA-5654743 1.035672e-02 1.985 0 0
Signaling by Erythropoietin R-HSA-9006335 1.038250e-02 1.984 0 0
Late endosomal microautophagy R-HSA-9615710 1.038250e-02 1.984 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 1.052166e-02 1.978 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 1.052166e-02 1.978 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.052166e-02 1.978 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.056441e-02 1.976 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.056441e-02 1.976 0 0
RET signaling R-HSA-8853659 1.059978e-02 1.975 0 0
GPVI-mediated activation cascade R-HSA-114604 1.059978e-02 1.975 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 1.059978e-02 1.975 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.099106e-02 1.959 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.110652e-02 1.954 0 0
Signaling by FGFR1 R-HSA-5654736 1.113651e-02 1.953 0 0
Nuclear Receptor transcription pathway R-HSA-383280 1.160859e-02 1.935 0 0
Formation of annular gap junctions R-HSA-196025 1.408218e-02 1.851 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.291602e-02 1.889 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.445832e-02 1.840 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.445832e-02 1.840 0 0
Ovarian tumor domain proteases R-HSA-5689896 1.279165e-02 1.893 0 0
Regulation of PTEN stability and activity R-HSA-8948751 1.349711e-02 1.870 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 1.324905e-02 1.878 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.258823e-02 1.900 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 1.451999e-02 1.838 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.474049e-02 1.831 0 0
Nephrin family interactions R-HSA-373753 1.445832e-02 1.840 0 0
Interleukin-2 signaling R-HSA-9020558 1.291602e-02 1.889 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.406730e-02 1.852 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.432549e-02 1.844 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.455237e-02 1.837 0 0
Signaling by FGFR3 R-HSA-5654741 1.451999e-02 1.838 0 0
Late Phase of HIV Life Cycle R-HSA-162599 1.239686e-02 1.907 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.358931e-02 1.867 0 0
Cellular response to hypoxia R-HSA-1234174 1.182397e-02 1.927 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 1.258823e-02 1.900 0 0
Gap junction trafficking R-HSA-190828 1.230030e-02 1.910 0 0
Hedgehog 'on' state R-HSA-5632684 1.474049e-02 1.831 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.408218e-02 1.851 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.408218e-02 1.851 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 1.238630e-02 1.907 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.408218e-02 1.851 0 0
Degradation of AXIN R-HSA-4641257 1.279165e-02 1.893 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 1.428210e-02 1.845 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.288113e-02 1.890 0 0
Peptide chain elongation R-HSA-156902 1.495130e-02 1.825 0 0
Degradation of CRY and PER proteins R-HSA-9932298 1.495968e-02 1.825 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.498280e-02 1.824 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.512802e-02 1.820 0 0
Growth hormone receptor signaling R-HSA-982772 1.519554e-02 1.818 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.522950e-02 1.817 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 1.532116e-02 1.815 0 0
Regulation of KIT signaling R-HSA-1433559 1.557062e-02 1.808 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.557128e-02 1.808 0 0
NOD1/2 Signaling Pathway R-HSA-168638 1.557294e-02 1.808 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.557294e-02 1.808 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.653660e-02 1.782 0 0
Neutrophil degranulation R-HSA-6798695 1.675279e-02 1.776 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.677079e-02 1.775 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 1.726452e-02 1.763 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.732548e-02 1.761 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.732548e-02 1.761 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.740273e-02 1.759 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 1.787463e-02 1.748 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 1.795032e-02 1.746 1 0
Activation of RAC1 R-HSA-428540 1.808089e-02 1.743 0 0
Signaling by ALK R-HSA-201556 1.821972e-02 1.739 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.838852e-02 1.735 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.867585e-02 1.729 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.867585e-02 1.729 0 0
Oncogene Induced Senescence R-HSA-2559585 1.867585e-02 1.729 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 1.875743e-02 1.727 0 0
Downstream TCR signaling R-HSA-202424 1.878583e-02 1.726 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.893497e-02 1.723 0 0
Neurodegenerative Diseases R-HSA-8863678 1.893497e-02 1.723 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.898877e-02 1.722 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 1.901665e-02 1.721 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 1.910081e-02 1.719 0 0
PCP/CE pathway R-HSA-4086400 2.021008e-02 1.694 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.055878e-02 1.687 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 2.055878e-02 1.687 0 0
Gap junction degradation R-HSA-190873 2.055878e-02 1.687 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 2.068678e-02 1.684 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 2.068678e-02 1.684 0 0
Defective pyroptosis R-HSA-9710421 2.072801e-02 1.683 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 2.097403e-02 1.678 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.230909e-02 1.652 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 2.230909e-02 1.652 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 2.244155e-02 1.649 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.244155e-02 1.649 0 0
Signaling by LTK in cancer R-HSA-9842640 2.244155e-02 1.649 0 0
Erythropoietin activates STAT5 R-HSA-9027283 2.244155e-02 1.649 0 0
Signal attenuation R-HSA-74749 2.880354e-02 1.541 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 2.880354e-02 1.541 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 2.880354e-02 1.541 0 0
PI3K/AKT activation R-HSA-198203 2.880354e-02 1.541 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 2.880354e-02 1.541 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.454740e-02 1.610 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 2.454740e-02 1.610 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 2.809763e-02 1.551 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.305203e-02 1.637 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 2.305203e-02 1.637 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.305203e-02 1.637 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 2.305203e-02 1.637 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 2.319550e-02 1.635 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 2.319550e-02 1.635 0 0
DAP12 signaling R-HSA-2424491 2.790213e-02 1.554 0 0
PRC2 methylates histones and DNA R-HSA-212300 2.222573e-02 1.653 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 2.197613e-02 1.658 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 2.527466e-02 1.597 0 0
Meiotic synapsis R-HSA-1221632 2.527466e-02 1.597 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 2.527466e-02 1.597 0 0
Protein ubiquitination R-HSA-8852135 2.420252e-02 1.616 0 0
Co-stimulation by CD28 R-HSA-389356 2.308170e-02 1.637 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 2.280469e-02 1.642 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 2.224757e-02 1.653 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 2.625783e-02 1.581 0 0
Translesion Synthesis by POLH R-HSA-110320 2.809763e-02 1.551 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.467049e-02 1.608 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 2.418031e-02 1.617 0 0
Pexophagy R-HSA-9664873 2.880354e-02 1.541 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 2.280469e-02 1.642 0 0
Signaling by FGFR2 R-HSA-5654738 2.547339e-02 1.594 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.347723e-02 1.629 0 0
Nef and signal transduction R-HSA-164944 2.244155e-02 1.649 0 0
Signaling by LTK R-HSA-9842663 2.454740e-02 1.610 0 0
Regulation of mitotic cell cycle R-HSA-453276 2.577001e-02 1.589 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 2.577001e-02 1.589 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 2.880354e-02 1.541 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.280469e-02 1.642 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 2.804773e-02 1.552 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 2.524943e-02 1.598 0 0
Interleukin-7 signaling R-HSA-1266695 2.331576e-02 1.632 0 0
MAP kinase activation R-HSA-450294 2.262603e-02 1.645 1 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.376009e-02 1.624 0 0
RUNX2 regulates bone development R-HSA-8941326 2.222573e-02 1.653 0 0
p75NTR recruits signalling complexes R-HSA-209543 2.454740e-02 1.610 0 0
Glycolysis R-HSA-70171 2.511312e-02 1.600 0 0
Negative regulation of FLT3 R-HSA-9706369 2.689369e-02 1.570 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 2.804773e-02 1.552 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 2.794871e-02 1.554 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.280469e-02 1.642 0 0
Interleukin-37 signaling R-HSA-9008059 2.790213e-02 1.554 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 2.524943e-02 1.598 0 0
Interleukin-1 family signaling R-HSA-446652 2.894391e-02 1.538 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 2.898382e-02 1.538 0 0
MyD88-independent TLR4 cascade R-HSA-166166 2.922992e-02 1.534 1 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 2.922992e-02 1.534 1 0
Regulated Necrosis R-HSA-5218859 3.090873e-02 1.510 0 0
Vesicle-mediated transport R-HSA-5653656 3.159318e-02 1.500 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 3.178059e-02 1.498 0 0
RAF activation R-HSA-5673000 3.209994e-02 1.493 0 0
Dual Incision in GG-NER R-HSA-5696400 3.209994e-02 1.493 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 3.209994e-02 1.493 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 3.209994e-02 1.493 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 3.235663e-02 1.490 0 0
Regulation of TNFR1 signaling R-HSA-5357905 3.235663e-02 1.490 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 3.235663e-02 1.490 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 3.244408e-02 1.489 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 3.244408e-02 1.489 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 3.244408e-02 1.489 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 3.249210e-02 1.488 0 0
Interferon Signaling R-HSA-913531 3.269129e-02 1.486 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 3.306426e-02 1.481 0 0
Death Receptor Signaling R-HSA-73887 3.372872e-02 1.472 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 3.421852e-02 1.466 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.427243e-02 1.465 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 3.428662e-02 1.465 0 0
Ub-specific processing proteases R-HSA-5689880 3.449863e-02 1.462 0 0
TCF dependent signaling in response to WNT R-HSA-201681 3.472767e-02 1.459 0 0
Co-inhibition by CTLA4 R-HSA-389513 3.495064e-02 1.457 0 0
Inositol phosphate metabolism R-HSA-1483249 3.503017e-02 1.456 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 3.613841e-02 1.442 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 3.613841e-02 1.442 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 3.679994e-02 1.434 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 3.741928e-02 1.427 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 3.888673e-02 1.410 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 3.896880e-02 1.409 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 3.908493e-02 1.408 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 3.932809e-02 1.405 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 3.955437e-02 1.403 0 0
Formation of paraxial mesoderm R-HSA-9793380 3.959804e-02 1.402 0 0
SARS-CoV Infections R-HSA-9679506 4.050688e-02 1.392 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 4.083944e-02 1.389 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 4.136579e-02 1.383 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 4.158005e-02 1.381 0 0
ER to Golgi Anterograde Transport R-HSA-199977 4.162134e-02 1.381 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 4.187713e-02 1.378 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 4.187713e-02 1.378 0 0
Interleukin-6 family signaling R-HSA-6783589 4.207994e-02 1.376 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 4.233401e-02 1.373 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 4.239854e-02 1.373 0 0
Signalling to RAS R-HSA-167044 4.287226e-02 1.368 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 4.294679e-02 1.367 0 0
FLT3 signaling in disease R-HSA-9682385 4.385925e-02 1.358 0 0
Smooth Muscle Contraction R-HSA-445355 4.514331e-02 1.345 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 4.529361e-02 1.344 0 0
G-protein beta:gamma signalling R-HSA-397795 4.612117e-02 1.336 0 0
Activation of ATR in response to replication stress R-HSA-176187 4.612117e-02 1.336 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 4.612117e-02 1.336 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 4.636476e-02 1.334 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 4.786374e-02 1.320 0 0
DNA methylation R-HSA-5334118 4.829764e-02 1.316 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 4.829764e-02 1.316 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 4.833968e-02 1.316 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 4.881361e-02 1.311 0 0
Diseases of Telomere Maintenance R-HSA-9673013 4.881361e-02 1.311 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 4.881361e-02 1.311 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 4.881361e-02 1.311 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 4.881361e-02 1.311 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 5.065692e-02 1.295 0 0
Signaling by FGFR R-HSA-190236 5.068384e-02 1.295 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 5.139022e-02 1.289 0 0
Somitogenesis R-HSA-9824272 5.139022e-02 1.289 0 0
Erythropoietin activates RAS R-HSA-9027284 5.292690e-02 1.276 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 5.292690e-02 1.276 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 5.292690e-02 1.276 0 0
p38MAPK events R-HSA-171007 5.292690e-02 1.276 0 0
Translesion synthesis by REV1 R-HSA-110312 5.292690e-02 1.276 0 0
p75NTR signals via NF-kB R-HSA-193639 5.292690e-02 1.276 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 5.292690e-02 1.276 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 5.293895e-02 1.276 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 5.902258e-02 1.229 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 5.395949e-02 1.268 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.395949e-02 1.268 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 5.395949e-02 1.268 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 5.395949e-02 1.268 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 6.242424e-02 1.205 0 0
Interleukin-21 signaling R-HSA-9020958 6.242424e-02 1.205 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 6.242424e-02 1.205 0 0
MAPK1 (ERK2) activation R-HSA-112411 6.242424e-02 1.205 0 0
ALK mutants bind TKIs R-HSA-9700645 6.242424e-02 1.205 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 6.544674e-02 1.184 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 6.544674e-02 1.184 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 6.544674e-02 1.184 0 0
Leading Strand Synthesis R-HSA-69109 6.544674e-02 1.184 0 0
Regulation of IFNG signaling R-HSA-877312 6.544674e-02 1.184 0 0
Polymerase switching R-HSA-69091 6.544674e-02 1.184 0 0
Translesion synthesis by POLI R-HSA-5656121 6.564554e-02 1.183 0 0
mTORC1-mediated signalling R-HSA-166208 6.212759e-02 1.207 0 0
Formation of definitive endoderm R-HSA-9823730 7.708605e-02 1.113 0 0
Negative regulation of MET activity R-HSA-6807004 7.708605e-02 1.113 0 0
Activation of the pre-replicative complex R-HSA-68962 5.662865e-02 1.247 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 5.662865e-02 1.247 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 5.662865e-02 1.247 0 0
Interaction between L1 and Ankyrins R-HSA-445095 6.972760e-02 1.157 0 0
EGFR downregulation R-HSA-182971 6.586101e-02 1.181 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 6.204273e-02 1.207 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 6.234892e-02 1.205 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 7.572446e-02 1.121 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 6.878076e-02 1.163 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 6.400844e-02 1.194 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 7.678821e-02 1.115 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 5.738687e-02 1.241 0 0
Dual incision in TC-NER R-HSA-6782135 7.920859e-02 1.101 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 7.704967e-02 1.113 0 0
Chromosome Maintenance R-HSA-73886 5.807100e-02 1.236 0 0
Nucleotide Excision Repair R-HSA-5696398 6.594648e-02 1.181 0 0
Signaling by FGFR1 in disease R-HSA-5655302 5.477951e-02 1.261 0 0
Interleukin-15 signaling R-HSA-8983432 6.544674e-02 1.184 0 0
MTOR signalling R-HSA-165159 6.234892e-02 1.205 0 0
STING mediated induction of host immune responses R-HSA-1834941 6.430965e-02 1.192 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 6.972760e-02 1.157 0 0
Myogenesis R-HSA-525793 5.949009e-02 1.226 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 6.564554e-02 1.183 0 0
Mitophagy R-HSA-5205647 6.204273e-02 1.207 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 6.349060e-02 1.197 0 0
Signal transduction by L1 R-HSA-445144 7.708605e-02 1.113 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 7.353211e-02 1.134 0 0
Signaling by PDGF R-HSA-186797 7.353211e-02 1.134 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 6.242424e-02 1.205 0 0
DNA strand elongation R-HSA-69190 7.601567e-02 1.119 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 7.150852e-02 1.146 0 0
RNA Polymerase I Transcription R-HSA-73864 5.494072e-02 1.260 0 0
TNF signaling R-HSA-75893 6.400844e-02 1.194 0 0
RMTs methylate histone arginines R-HSA-3214858 7.951617e-02 1.100 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 5.904626e-02 1.229 0 0
Protein-protein interactions at synapses R-HSA-6794362 6.762581e-02 1.170 0 0
Budding and maturation of HIV virion R-HSA-162588 6.586101e-02 1.181 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 7.314964e-02 1.136 0 0
Meiosis R-HSA-1500620 6.762581e-02 1.170 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 7.614699e-02 1.118 1 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 7.614699e-02 1.118 1 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 7.614699e-02 1.118 1 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 5.395949e-02 1.268 0 0
Signaling by NOTCH R-HSA-157118 7.268796e-02 1.139 0 0
Interleukin-17 signaling R-HSA-448424 6.349060e-02 1.197 1 0
DNA Repair R-HSA-73894 5.822167e-02 1.235 0 0
Circadian clock R-HSA-9909396 7.258982e-02 1.139 0 0
Eukaryotic Translation Termination R-HSA-72764 5.938851e-02 1.226 0 0
Cilium Assembly R-HSA-5617833 7.407954e-02 1.130 0 0
Interleukin-1 signaling R-HSA-9020702 6.535479e-02 1.185 0 0
Gap junction assembly R-HSA-190861 6.204273e-02 1.207 0 0
Unwinding of DNA R-HSA-176974 6.242424e-02 1.205 0 0
Potential therapeutics for SARS R-HSA-9679191 7.223647e-02 1.141 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 7.002818e-02 1.155 0 0
tRNA processing in the nucleus R-HSA-6784531 7.353211e-02 1.134 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 5.833678e-02 1.234 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 5.528001e-02 1.257 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 7.601567e-02 1.119 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 7.121811e-02 1.147 0 0
SARS-CoV-2 Infection R-HSA-9694516 5.674076e-02 1.246 0 0
SARS-CoV-1 Infection R-HSA-9678108 7.535122e-02 1.123 0 0
Maturation of protein E R-HSA-9694493 5.395949e-02 1.268 0 0
Maturation of protein E R-HSA-9683683 5.395949e-02 1.268 0 0
Translesion synthesis by POLK R-HSA-5655862 8.005587e-02 1.097 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 8.101528e-02 1.091 0 0
G1/S-Specific Transcription R-HSA-69205 8.122613e-02 1.090 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 8.123675e-02 1.090 0 0
Formation of apoptosome R-HSA-111458 8.123675e-02 1.090 0 0
Signaling by Leptin R-HSA-2586552 8.123675e-02 1.090 0 0
Regulation of the apoptosome activity R-HSA-9627069 8.123675e-02 1.090 0 0
Interleukin-27 signaling R-HSA-9020956 8.123675e-02 1.090 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 8.183397e-02 1.087 0 0
Formation of axial mesoderm R-HSA-9796292 8.183397e-02 1.087 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 8.183397e-02 1.087 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 8.183397e-02 1.087 0 0
Frs2-mediated activation R-HSA-170968 8.183397e-02 1.087 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 8.298874e-02 1.081 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 8.305545e-02 1.081 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 8.337291e-02 1.079 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 8.538409e-02 1.069 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 8.564822e-02 1.067 0 0
Nuclear RNA decay R-HSA-9930044 8.710552e-02 1.060 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 8.710552e-02 1.060 0 0
Chaperonin-mediated protein folding R-HSA-390466 8.745194e-02 1.058 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 8.762240e-02 1.057 1 0
Nucleosome assembly R-HSA-774815 8.913752e-02 1.050 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 8.913752e-02 1.050 0 0
IGF1R signaling cascade R-HSA-2428924 8.950018e-02 1.048 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 9.004817e-02 1.046 0 0
Regulation of gap junction activity R-HSA-191650 9.004817e-02 1.046 0 0
MTF1 activates gene expression R-HSA-5660489 9.004817e-02 1.046 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 9.004817e-02 1.046 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 9.004817e-02 1.046 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 9.004817e-02 1.046 0 0
Signaling by MAP2K mutants R-HSA-9652169 9.004817e-02 1.046 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 9.004817e-02 1.046 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 9.004817e-02 1.046 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 9.127540e-02 1.040 0 0
ERK/MAPK targets R-HSA-198753 9.127540e-02 1.040 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 9.127540e-02 1.040 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 9.207600e-02 1.036 0 0
Gastrulation R-HSA-9758941 9.315155e-02 1.031 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.336139e-02 1.030 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 9.336139e-02 1.030 0 0
Regulation of gene expression in beta cells R-HSA-210745 9.336139e-02 1.030 0 0
Protein folding R-HSA-391251 9.531703e-02 1.021 0 0
MHC class II antigen presentation R-HSA-2132295 9.554766e-02 1.020 0 0
Selenocysteine synthesis R-HSA-2408557 9.587760e-02 1.018 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 9.615137e-02 1.017 0 0
Co-inhibition by PD-1 R-HSA-389948 9.665353e-02 1.015 0 0
Manipulation of host energy metabolism R-HSA-9636667 9.815231e-02 1.008 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 9.815231e-02 1.008 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 9.815231e-02 1.008 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 9.815231e-02 1.008 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 9.815231e-02 1.008 0 0
Breakdown of the nuclear lamina R-HSA-352238 9.815231e-02 1.008 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 9.826096e-02 1.008 0 0
MITF-M-dependent gene expression R-HSA-9856651 9.891062e-02 1.005 0 0
Resolution of D-Loop Structures R-HSA-5693537 9.913517e-02 1.004 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 9.945913e-02 1.002 0 0
Diseases of DNA repair R-HSA-9675135 9.945913e-02 1.002 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 9.960394e-02 1.002 0 0
HDMs demethylate histones R-HSA-3214842 9.997004e-02 1.000 0 0
Long-term potentiation R-HSA-9620244 9.997004e-02 1.000 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 1.002919e-01 0.999 0 0
Retrograde neurotrophin signalling R-HSA-177504 1.002919e-01 0.999 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 1.002919e-01 0.999 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 1.002919e-01 0.999 0 0
Signal regulatory protein family interactions R-HSA-391160 1.002919e-01 0.999 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 1.006759e-01 0.997 0 0
IFNG signaling activates MAPKs R-HSA-9732724 1.012302e-01 0.995 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 1.012302e-01 0.995 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 1.012302e-01 0.995 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 1.012302e-01 0.995 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 1.012302e-01 0.995 0 0
Signaling by MET R-HSA-6806834 1.015139e-01 0.993 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 1.021667e-01 0.991 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 1.027166e-01 0.988 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.031347e-01 0.987 0 0
NRAGE signals death through JNK R-HSA-193648 1.043645e-01 0.981 0 0
Viral Infection Pathways R-HSA-9824446 1.046206e-01 0.980 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.061346e-01 0.974 0 0
Activation of BH3-only proteins R-HSA-114452 1.067633e-01 0.972 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.068651e-01 0.971 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.068651e-01 0.971 0 0
Viral mRNA Translation R-HSA-192823 1.107359e-01 0.956 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 1.121008e-01 0.950 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 1.121008e-01 0.950 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 1.121008e-01 0.950 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.128660e-01 0.947 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 1.128660e-01 0.947 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.134500e-01 0.945 0 0
Tie2 Signaling R-HSA-210993 1.138971e-01 0.943 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.138971e-01 0.943 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.149895e-01 0.939 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.149895e-01 0.939 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.162246e-01 0.935 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.163047e-01 0.934 0 0
Generic Transcription Pathway R-HSA-212436 1.180705e-01 0.928 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 1.182654e-01 0.927 1 0
DCC mediated attractive signaling R-HSA-418885 1.207454e-01 0.918 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.207454e-01 0.918 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.207454e-01 0.918 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.207454e-01 0.918 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 1.212078e-01 0.916 0 0
Notch-HLH transcription pathway R-HSA-350054 1.238235e-01 0.907 0 0
Glucose metabolism R-HSA-70326 1.249174e-01 0.903 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 1.263528e-01 0.898 1 0
Nectin/Necl trans heterodimerization R-HSA-420597 1.264189e-01 0.898 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.264189e-01 0.898 0 0
IRS activation R-HSA-74713 1.264189e-01 0.898 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 1.264189e-01 0.898 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 1.267089e-01 0.897 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.267089e-01 0.897 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 1.267089e-01 0.897 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.267089e-01 0.897 0 0
NF-kB is activated and signals survival R-HSA-209560 1.267089e-01 0.897 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.267089e-01 0.897 0 0
G alpha (12/13) signalling events R-HSA-416482 1.284955e-01 0.891 0 0
Interleukin-12 family signaling R-HSA-447115 1.285188e-01 0.891 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 1.296683e-01 0.887 0 0
Type I hemidesmosome assembly R-HSA-446107 1.301294e-01 0.886 0 0
RSK activation R-HSA-444257 1.301294e-01 0.886 0 0
Interleukin-9 signaling R-HSA-8985947 1.301294e-01 0.886 0 0
Modulation by Mtb of host immune system R-HSA-9637628 1.301294e-01 0.886 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 1.311769e-01 0.882 0 0
DAP12 interactions R-HSA-2172127 1.324821e-01 0.878 0 0
Rap1 signalling R-HSA-392517 1.332316e-01 0.875 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.332316e-01 0.875 0 0
DNA Damage Bypass R-HSA-73893 1.346093e-01 0.871 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.346093e-01 0.871 0 0
Drug resistance of KIT mutants R-HSA-9669937 1.608069e-01 0.794 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.608069e-01 0.794 0 0
KIT mutants bind TKIs R-HSA-9669921 1.608069e-01 0.794 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.608069e-01 0.794 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.608069e-01 0.794 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.608069e-01 0.794 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.608069e-01 0.794 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 1.608069e-01 0.794 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.608069e-01 0.794 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.608069e-01 0.794 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 1.608069e-01 0.794 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 1.608069e-01 0.794 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.608069e-01 0.794 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 1.608069e-01 0.794 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 1.608069e-01 0.794 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.608069e-01 0.794 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.608069e-01 0.794 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 1.608069e-01 0.794 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 1.608069e-01 0.794 0 0
Regulation of TP53 Expression R-HSA-6804754 1.562218e-01 0.806 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 1.562218e-01 0.806 0 0
Regulation of cortical dendrite branching R-HSA-8985801 1.562218e-01 0.806 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 1.562218e-01 0.806 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 1.562218e-01 0.806 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 1.562218e-01 0.806 0 0
Signaling by FGFR1 amplification mutants R-HSA-1839120 2.189402e-01 0.660 0 0
The NLRP1 inflammasome R-HSA-844455 2.189402e-01 0.660 0 0
TRKA activation by NGF R-HSA-187042 2.189402e-01 0.660 0 0
PLC-gamma1 signalling R-HSA-167021 2.189402e-01 0.660 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 2.189402e-01 0.660 0 0
MET interacts with TNS proteins R-HSA-8875513 2.189402e-01 0.660 0 0
Axonal growth stimulation R-HSA-209563 2.189402e-01 0.660 0 0
MET activates PTPN11 R-HSA-8865999 2.189402e-01 0.660 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.670639e-01 0.777 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 1.670639e-01 0.777 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.619952e-01 0.790 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 2.108853e-01 0.676 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 1.530019e-01 0.815 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.530019e-01 0.815 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.530019e-01 0.815 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.530019e-01 0.815 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.530019e-01 0.815 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.530019e-01 0.815 0 0
2-LTR circle formation R-HSA-164843 1.963417e-01 0.707 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 1.963417e-01 0.707 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.430811e-01 0.844 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.430811e-01 0.844 0 0
Activation of TRKA receptors R-HSA-187015 2.568321e-01 0.590 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 2.568321e-01 0.590 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 2.568321e-01 0.590 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.568321e-01 0.590 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 2.568321e-01 0.590 0 0
TRIF-mediated programmed cell death R-HSA-2562578 2.568321e-01 0.590 0 0
SOS-mediated signalling R-HSA-112412 2.568321e-01 0.590 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 2.568321e-01 0.590 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 1.671534e-01 0.777 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 1.671534e-01 0.777 0 0
Signaling by APC mutants R-HSA-4839744 2.326561e-01 0.633 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 2.326561e-01 0.633 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 2.326561e-01 0.633 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 2.326561e-01 0.633 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 1.540694e-01 0.812 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.540694e-01 0.812 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.540694e-01 0.812 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.540694e-01 0.812 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.540694e-01 0.812 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 2.704225e-01 0.568 0 0
ERKs are inactivated R-HSA-202670 2.704225e-01 0.568 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 2.429814e-01 0.614 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 2.429814e-01 0.614 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.429814e-01 0.614 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 2.429814e-01 0.614 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 2.197984e-01 0.658 0 0
GAB1 signalosome R-HSA-180292 2.197984e-01 0.658 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 1.823284e-01 0.739 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 1.823284e-01 0.739 0 0
Termination of translesion DNA synthesis R-HSA-5656169 1.668800e-01 0.778 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.531186e-01 0.815 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 1.438435e-01 0.842 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 2.244486e-01 0.649 0 0
FGFR2 alternative splicing R-HSA-6803529 2.244486e-01 0.649 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 2.479722e-01 0.606 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 2.268486e-01 0.644 0 0
Packaging Of Telomere Ends R-HSA-171306 2.268486e-01 0.644 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 1.604131e-01 0.795 0 0
MET promotes cell motility R-HSA-8875878 2.695001e-01 0.569 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 2.630668e-01 0.580 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 2.363840e-01 0.626 0 0
HCMV Early Events R-HSA-9609690 2.121658e-01 0.673 0 0
Telomere Maintenance R-HSA-157579 1.465311e-01 0.834 0 0
Interleukin-35 Signalling R-HSA-8984722 1.530019e-01 0.815 0 0
FGFR1 mutant receptor activation R-HSA-1839124 1.531186e-01 0.815 0 0
Insulin receptor signalling cascade R-HSA-74751 1.380639e-01 0.860 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 2.293811e-01 0.639 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 2.076462e-01 0.683 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 2.076462e-01 0.683 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 2.076462e-01 0.683 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 2.041033e-01 0.690 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 2.270507e-01 0.644 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 2.244486e-01 0.649 0 0
G0 and Early G1 R-HSA-1538133 1.366708e-01 0.864 0 0
Parasite infection R-HSA-9664407 1.692172e-01 0.772 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 1.692172e-01 0.772 0 0
Leishmania phagocytosis R-HSA-9664417 1.692172e-01 0.772 0 0
Integration of provirus R-HSA-162592 2.704225e-01 0.568 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 2.704225e-01 0.568 0 0
Neurexins and neuroligins R-HSA-6794361 2.596657e-01 0.586 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 1.531186e-01 0.815 0 0
Rab regulation of trafficking R-HSA-9007101 2.246723e-01 0.648 0 0
Apoptotic factor-mediated response R-HSA-111471 2.197984e-01 0.658 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 2.568321e-01 0.590 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 1.564502e-01 0.806 0 0
Signaling by NOTCH3 R-HSA-9012852 2.224843e-01 0.653 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 1.670639e-01 0.777 0 0
MAPK3 (ERK1) activation R-HSA-110056 1.963417e-01 0.707 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 2.479722e-01 0.606 0 0
Germ layer formation at gastrulation R-HSA-9754189 2.479722e-01 0.606 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 2.066110e-01 0.685 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 1.896213e-01 0.722 1 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.114034e-01 0.675 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 1.896213e-01 0.722 1 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 2.214202e-01 0.655 1 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 2.307423e-01 0.637 0 0
Signaling by TGFB family members R-HSA-9006936 1.693143e-01 0.771 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 1.421004e-01 0.847 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 2.214202e-01 0.655 1 0
Signaling by WNT R-HSA-195721 2.560613e-01 0.592 0 0
TRAIL signaling R-HSA-75158 1.670639e-01 0.777 0 0
Cellular response to mitochondrial stress R-HSA-9840373 1.619952e-01 0.790 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 1.671534e-01 0.777 0 0
Signaling by FGFR4 in disease R-HSA-5655291 2.114349e-01 0.675 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 1.616292e-01 0.791 0 0
Platelet sensitization by LDL R-HSA-432142 2.197984e-01 0.658 0 0
Signaling by FGFR in disease R-HSA-1226099 2.000876e-01 0.699 0 0
ER-Phagosome pathway R-HSA-1236974 2.065683e-01 0.685 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 1.998096e-01 0.699 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 1.892434e-01 0.723 0 0
PLC beta mediated events R-HSA-112043 2.363840e-01 0.626 0 0
G-protein mediated events R-HSA-112040 1.748437e-01 0.757 0 0
FasL/ CD95L signaling R-HSA-75157 2.189402e-01 0.660 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 1.619707e-01 0.791 1 0
PI Metabolism R-HSA-1483255 2.643286e-01 0.578 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 1.920015e-01 0.717 1 0
Ca-dependent events R-HSA-111996 2.663677e-01 0.575 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.740345e-01 0.759 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 1.438435e-01 0.842 0 0
DAG and IP3 signaling R-HSA-1489509 2.258499e-01 0.646 0 0
Signaling by NOTCH1 R-HSA-1980143 2.278752e-01 0.642 0 0
Interleukin-20 family signaling R-HSA-8854691 1.421004e-01 0.847 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 1.430811e-01 0.844 0 0
Organelle biogenesis and maintenance R-HSA-1852241 2.568215e-01 0.590 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 2.328873e-01 0.633 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.410503e-01 0.851 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.562218e-01 0.806 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 2.189402e-01 0.660 0 0
Glycogen storage diseases R-HSA-3229121 1.927900e-01 0.715 0 0
Signaling by AMER1 mutants R-HSA-4839748 2.704225e-01 0.568 0 0
Signaling by AXIN mutants R-HSA-4839735 2.704225e-01 0.568 0 0
Synaptic adhesion-like molecules R-HSA-8849932 2.197984e-01 0.658 0 0
Meiotic recombination R-HSA-912446 2.417313e-01 0.617 0 0
Muscle contraction R-HSA-397014 1.410503e-01 0.851 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.531186e-01 0.815 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 2.244486e-01 0.649 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.963417e-01 0.707 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.619952e-01 0.790 0 0
NRIF signals cell death from the nucleus R-HSA-205043 2.114349e-01 0.675 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.881220e-01 0.726 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 2.323052e-01 0.634 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.460892e-01 0.835 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 2.041033e-01 0.690 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 2.114349e-01 0.675 0 0
Interleukin-12 signaling R-HSA-9020591 1.611454e-01 0.793 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 1.758119e-01 0.755 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 1.530019e-01 0.815 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 1.530019e-01 0.815 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 1.902593e-01 0.721 0 0
Assembly Of The HIV Virion R-HSA-175474 1.998096e-01 0.699 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.887862e-01 0.724 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 2.183395e-01 0.661 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.670639e-01 0.777 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.391115e-01 0.621 0 0
Gene Silencing by RNA R-HSA-211000 1.538916e-01 0.813 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 2.723608e-01 0.565 0 0
Sensory processing of sound R-HSA-9659379 2.724148e-01 0.565 0 0
Phosphorylation of the APC/C R-HSA-176412 2.756642e-01 0.560 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 2.757559e-01 0.559 0 0
Deadenylation of mRNA R-HSA-429947 2.765189e-01 0.558 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 2.765189e-01 0.558 0 0
Glycogen synthesis R-HSA-3322077 2.770962e-01 0.557 0 0
Signaling by NODAL R-HSA-1181150 2.770962e-01 0.557 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 2.833122e-01 0.548 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 2.833122e-01 0.548 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 2.833122e-01 0.548 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 2.833122e-01 0.548 0 0
Sensory perception of sour taste R-HSA-9729555 2.833122e-01 0.548 0 0
Antigen processing-Cross presentation R-HSA-1236975 2.862198e-01 0.543 0 0
Response of Mtb to phagocytosis R-HSA-9637690 2.868120e-01 0.542 0 0
Plasma lipoprotein clearance R-HSA-8964043 2.912066e-01 0.536 0 0
Regulation of beta-cell development R-HSA-186712 2.916563e-01 0.535 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 2.957625e-01 0.529 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.957625e-01 0.529 0 0
TGFBR2 MSI Frameshift Mutants in Cancer R-HSA-3642279 2.957625e-01 0.529 0 0
SARS-CoV-1 targets PDZ proteins in cell-cell junction R-HSA-9692912 2.957625e-01 0.529 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.957625e-01 0.529 0 0
TICAM1 deficiency - HSE R-HSA-5602566 2.957625e-01 0.529 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.957625e-01 0.529 0 0
Activation and oligomerization of BAK protein R-HSA-111452 2.957625e-01 0.529 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.957625e-01 0.529 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 2.957625e-01 0.529 0 0
SDK interactions R-HSA-373756 2.957625e-01 0.529 0 0
Inhibition of PKR R-HSA-169131 2.957625e-01 0.529 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 2.968159e-01 0.528 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 2.981286e-01 0.526 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 2.981286e-01 0.526 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 3.021804e-01 0.520 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 3.036318e-01 0.518 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 3.039450e-01 0.517 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.039450e-01 0.517 0 0
MET receptor recycling R-HSA-8875656 3.039450e-01 0.517 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 3.039450e-01 0.517 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.039450e-01 0.517 0 0
Interleukin-23 signaling R-HSA-9020933 3.039450e-01 0.517 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 3.039450e-01 0.517 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 3.039450e-01 0.517 0 0
Co-stimulation by ICOS R-HSA-9927354 3.039450e-01 0.517 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.039450e-01 0.517 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 3.069523e-01 0.513 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 3.069523e-01 0.513 0 0
Lagging Strand Synthesis R-HSA-69186 3.069523e-01 0.513 0 0
Early Phase of HIV Life Cycle R-HSA-162594 3.069523e-01 0.513 0 0
Netrin-1 signaling R-HSA-373752 3.076882e-01 0.512 0 0
Proteasome assembly R-HSA-9907900 3.076882e-01 0.512 0 0
Cellular response to starvation R-HSA-9711097 3.079840e-01 0.511 0 0
MET activates RAS signaling R-HSA-8851805 3.091409e-01 0.510 0 0
Repression of WNT target genes R-HSA-4641265 3.091409e-01 0.510 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 3.091409e-01 0.510 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 3.091409e-01 0.510 0 0
IRAK1 recruits IKK complex R-HSA-937039 3.091409e-01 0.510 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 3.091409e-01 0.510 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 3.091692e-01 0.510 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 3.091692e-01 0.510 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 3.091692e-01 0.510 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 3.091692e-01 0.510 0 0
Synthesis of PG R-HSA-1483148 3.091692e-01 0.510 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 3.099136e-01 0.509 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 3.099136e-01 0.509 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 3.099136e-01 0.509 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 3.099136e-01 0.509 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 3.099136e-01 0.509 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 3.191964e-01 0.496 0 0
PI3K Cascade R-HSA-109704 3.223000e-01 0.492 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 3.251726e-01 0.488 0 0
Cellular response to chemical stress R-HSA-9711123 3.277380e-01 0.484 0 0
Metalloprotease DUBs R-HSA-5689901 3.312471e-01 0.480 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 3.358817e-01 0.474 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 3.373242e-01 0.472 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 3.373242e-01 0.472 0 0
Signaling by Insulin receptor R-HSA-74752 3.382997e-01 0.471 0 0
ABC transporter disorders R-HSA-5619084 3.430092e-01 0.465 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 3.431911e-01 0.464 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 3.431911e-01 0.464 0 0
Calmodulin induced events R-HSA-111933 3.432119e-01 0.464 0 0
CaM pathway R-HSA-111997 3.432119e-01 0.464 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 3.471850e-01 0.459 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 3.471850e-01 0.459 0 0
Activation of AKT2 R-HSA-165158 3.471850e-01 0.459 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 3.471850e-01 0.459 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 3.471850e-01 0.459 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 3.471850e-01 0.459 0 0
PTK6 Activates STAT3 R-HSA-8849474 3.471850e-01 0.459 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 3.471850e-01 0.459 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 3.483415e-01 0.458 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 3.483415e-01 0.458 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 3.483415e-01 0.458 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 3.483415e-01 0.458 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 3.483415e-01 0.458 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 3.509657e-01 0.455 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 3.513800e-01 0.454 0 0
ARMS-mediated activation R-HSA-170984 3.513800e-01 0.454 0 0
Lipophagy R-HSA-9613354 3.513800e-01 0.454 0 0
Calcineurin activates NFAT R-HSA-2025928 3.513800e-01 0.454 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 3.513800e-01 0.454 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 3.513800e-01 0.454 0 0
p75NTR regulates axonogenesis R-HSA-193697 3.513800e-01 0.454 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 3.513800e-01 0.454 0 0
rRNA processing R-HSA-72312 3.543901e-01 0.451 0 0
IRS-mediated signalling R-HSA-112399 3.550725e-01 0.450 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 3.592043e-01 0.445 0 0
Platelet degranulation R-HSA-114608 3.621427e-01 0.441 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 3.721908e-01 0.429 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 3.727098e-01 0.429 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 3.774397e-01 0.423 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 3.816720e-01 0.418 0 0
Depyrimidination R-HSA-73928 3.816720e-01 0.418 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 3.847210e-01 0.415 0 0
Activation of HOX genes during differentiation R-HSA-5619507 3.847210e-01 0.415 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 3.858663e-01 0.414 0 0
Inflammasomes R-HSA-622312 3.873468e-01 0.412 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 3.875941e-01 0.412 0 0
Removal of the Flap Intermediate R-HSA-69166 3.875941e-01 0.412 0 0
Physiological factors R-HSA-5578768 3.875941e-01 0.412 0 0
ABC-family proteins mediated transport R-HSA-382556 3.928264e-01 0.406 0 0
GPER1 signaling R-HSA-9634597 3.940757e-01 0.404 0 0
Intraflagellar transport R-HSA-5620924 3.940757e-01 0.404 0 0
Amyloid fiber formation R-HSA-977225 3.945547e-01 0.404 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 3.949815e-01 0.403 0 0
DNA replication initiation R-HSA-68952 3.984191e-01 0.400 0 0
Folding of actin by CCT/TriC R-HSA-390450 3.984191e-01 0.400 0 0
Regulation of CDH11 function R-HSA-9762292 3.984191e-01 0.400 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 3.984191e-01 0.400 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 3.987813e-01 0.399 0 0
Syndecan interactions R-HSA-3000170 3.987813e-01 0.399 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 4.031297e-01 0.395 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 4.090216e-01 0.388 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 4.090216e-01 0.388 0 0
Defective VWF binding to collagen type I R-HSA-9845622 4.090216e-01 0.388 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5619101 4.090216e-01 0.388 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 4.090216e-01 0.388 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 4.090216e-01 0.388 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5660686 4.090216e-01 0.388 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 4.090216e-01 0.388 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 4.090216e-01 0.388 0 0
Defective TPMT causes TPMT deficiency R-HSA-5578995 4.090216e-01 0.388 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 4.090216e-01 0.388 0 0
TRAF3 deficiency - HSE R-HSA-5602571 4.090216e-01 0.388 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 4.090216e-01 0.388 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 4.090216e-01 0.388 0 0
Beta-ketothiolase deficiency R-HSA-9915355 4.090216e-01 0.388 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 4.090216e-01 0.388 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 4.090216e-01 0.388 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 4.090216e-01 0.388 0 0
Transport of connexins along the secretory pathway R-HSA-190827 4.090216e-01 0.388 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 4.090216e-01 0.388 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 4.090216e-01 0.388 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 4.090216e-01 0.388 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 4.090216e-01 0.388 0 0
Oligomerization of connexins into connexons R-HSA-190704 4.090216e-01 0.388 0 0
Inhibition of membrane repair R-HSA-9635644 4.090216e-01 0.388 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 4.090548e-01 0.388 0 0
NGF-independant TRKA activation R-HSA-187024 4.090548e-01 0.388 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 4.090548e-01 0.388 0 0
PDE3B signalling R-HSA-165160 4.090548e-01 0.388 0 0
PKB-mediated events R-HSA-109703 4.090548e-01 0.388 0 0
Signaling by MAPK mutants R-HSA-9652817 4.090548e-01 0.388 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 4.090548e-01 0.388 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 4.090548e-01 0.388 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 4.090548e-01 0.388 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 4.090548e-01 0.388 0 0
VEGF ligand-receptor interactions R-HSA-194313 4.090548e-01 0.388 0 0
E2F mediated regulation of DNA replication R-HSA-113510 4.116444e-01 0.385 0 0
The NLRP3 inflammasome R-HSA-844456 4.116444e-01 0.385 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 4.116444e-01 0.385 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 4.155246e-01 0.381 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 4.155246e-01 0.381 0 0
Processive synthesis on the lagging strand R-HSA-69183 4.265145e-01 0.370 0 0
Biotin transport and metabolism R-HSA-196780 4.265145e-01 0.370 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 4.265145e-01 0.370 0 0
Protein methylation R-HSA-8876725 4.265145e-01 0.370 0 0
Signaling by Activin R-HSA-1502540 4.265145e-01 0.370 0 0
Signaling by NOTCH2 R-HSA-1980145 4.292614e-01 0.367 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 4.293723e-01 0.367 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 4.294754e-01 0.367 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 4.408958e-01 0.356 0 0
Glycogen metabolism R-HSA-8982491 4.408958e-01 0.356 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 4.435954e-01 0.353 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 4.435954e-01 0.353 0 0
Toll-like Receptor Cascades R-HSA-168898 4.442341e-01 0.352 1 0
Activated NTRK3 signals through RAS R-HSA-9034864 4.444694e-01 0.352 0 0
Bicarbonate transporters R-HSA-425381 4.444694e-01 0.352 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 4.444694e-01 0.352 0 0
Suppression of apoptosis R-HSA-9635465 4.444694e-01 0.352 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 4.444694e-01 0.352 0 0
ChREBP activates metabolic gene expression R-HSA-163765 4.444694e-01 0.352 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 4.444694e-01 0.352 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 4.455582e-01 0.351 0 0
Ion homeostasis R-HSA-5578775 4.470023e-01 0.350 0 0
Fanconi Anemia Pathway R-HSA-6783310 4.509856e-01 0.346 0 0
Opioid Signalling R-HSA-111885 4.552158e-01 0.342 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 4.575778e-01 0.340 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 4.647679e-01 0.333 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 4.647679e-01 0.333 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 4.647679e-01 0.333 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 4.647679e-01 0.333 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 4.647679e-01 0.333 0 0
Regulation of BACH1 activity R-HSA-9708530 4.647679e-01 0.333 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 4.652410e-01 0.332 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 4.652410e-01 0.332 0 0
FOXO-mediated transcription R-HSA-9614085 4.653403e-01 0.332 0 0
STAT5 Activation R-HSA-9645135 4.679143e-01 0.330 0 0
Autointegration results in viral DNA circles R-HSA-177539 4.679143e-01 0.330 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 4.679143e-01 0.330 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 4.679143e-01 0.330 0 0
CREB phosphorylation R-HSA-199920 4.679143e-01 0.330 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 4.679143e-01 0.330 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 4.751229e-01 0.323 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 4.753811e-01 0.323 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 4.759564e-01 0.322 0 0
Basigin interactions R-HSA-210991 4.789598e-01 0.320 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 4.789598e-01 0.320 0 0
HCMV Infection R-HSA-9609646 4.808337e-01 0.318 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 4.809628e-01 0.318 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 4.816716e-01 0.317 0 0
Hemostasis R-HSA-109582 4.818763e-01 0.317 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 4.890574e-01 0.311 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 4.890574e-01 0.311 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 4.890574e-01 0.311 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.890574e-01 0.311 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 4.893780e-01 0.310 0 0
HIV Transcription Initiation R-HSA-167161 4.893780e-01 0.310 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 4.893780e-01 0.310 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 4.893780e-01 0.310 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 4.899188e-01 0.310 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 4.899188e-01 0.310 0 0
Suppression of phagosomal maturation R-HSA-9637687 4.899188e-01 0.310 0 0
Developmental Cell Lineages R-HSA-9734767 4.972122e-01 0.303 0 0
XBP1(S) activates chaperone genes R-HSA-381038 4.988675e-01 0.302 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 5.020693e-01 0.299 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 5.020693e-01 0.299 0 0
NTF4 activates NTRK2 (TRKB) signaling R-HSA-9026357 5.040712e-01 0.298 0 0
BDNF activates NTRK2 (TRKB) signaling R-HSA-9024909 5.040712e-01 0.298 0 0
NTF3 activates NTRK2 (TRKB) signaling R-HSA-9025046 5.040712e-01 0.298 0 0
Glycogen storage disease type IV (GBE1) R-HSA-3878781 5.040712e-01 0.298 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 5.040712e-01 0.298 0 0
Signaling by RAS GAP mutants R-HSA-9753510 5.040712e-01 0.298 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 5.040712e-01 0.298 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 5.040712e-01 0.298 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 5.040712e-01 0.298 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 5.040712e-01 0.298 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 5.040712e-01 0.298 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 5.040712e-01 0.298 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 5.040712e-01 0.298 0 0
mRNA Editing: A to I Conversion R-HSA-75064 5.040712e-01 0.298 0 0
The AIM2 inflammasome R-HSA-844615 5.040712e-01 0.298 0 0
C6 deamination of adenosine R-HSA-75102 5.040712e-01 0.298 0 0
Diseases of cellular response to stress R-HSA-9675132 5.040712e-01 0.298 0 0
DSCAM interactions R-HSA-376172 5.040712e-01 0.298 0 0
Diseases of Cellular Senescence R-HSA-9630747 5.040712e-01 0.298 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 5.052119e-01 0.297 0 0
Parasitic Infection Pathways R-HSA-9824443 5.059469e-01 0.296 0 0
Leishmania infection R-HSA-9658195 5.059469e-01 0.296 0 0
Cleavage of the damaged purine R-HSA-110331 5.065395e-01 0.295 0 0
Extension of Telomeres R-HSA-180786 5.092142e-01 0.293 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 5.092142e-01 0.293 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 5.116546e-01 0.291 0 0
Attachment and Entry R-HSA-9694614 5.116546e-01 0.291 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 5.132270e-01 0.290 0 0
NGF-stimulated transcription R-HSA-9031628 5.191956e-01 0.285 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 5.193649e-01 0.285 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 5.193649e-01 0.285 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 5.193649e-01 0.285 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 5.213276e-01 0.283 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 5.231316e-01 0.281 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 5.231316e-01 0.281 0 0
DAG1 core M1 glycosylations R-HSA-8932506 5.231316e-01 0.281 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 5.231316e-01 0.281 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 5.231316e-01 0.281 0 0
Netrin mediated repulsion signals R-HSA-418886 5.231316e-01 0.281 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 5.231316e-01 0.281 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 5.231316e-01 0.281 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 5.231316e-01 0.281 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 5.258921e-01 0.279 0 0
Depurination R-HSA-73927 5.316028e-01 0.274 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 5.318191e-01 0.274 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 5.318191e-01 0.274 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 5.318191e-01 0.274 0 0
Scavenging by Class F Receptors R-HSA-3000484 5.318191e-01 0.274 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 5.318191e-01 0.274 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 5.318191e-01 0.274 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 5.367143e-01 0.270 0 0
TBC/RABGAPs R-HSA-8854214 5.367143e-01 0.270 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 5.381830e-01 0.269 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 5.381830e-01 0.269 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 5.381830e-01 0.269 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 5.434754e-01 0.265 0 0
LDL clearance R-HSA-8964038 5.434754e-01 0.265 0 0
HIV elongation arrest and recovery R-HSA-167287 5.481199e-01 0.261 0 0
Pausing and recovery of HIV elongation R-HSA-167290 5.481199e-01 0.261 0 0
Pyroptosis R-HSA-5620971 5.481199e-01 0.261 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 5.561765e-01 0.255 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 5.602567e-01 0.252 0 0
Base Excision Repair R-HSA-73884 5.664977e-01 0.247 0 0
NCAM signaling for neurite out-growth R-HSA-375165 5.693997e-01 0.245 0 0
Transcription of the HIV genome R-HSA-167172 5.723118e-01 0.242 0 0
CD28 dependent Vav1 pathway R-HSA-389359 5.724878e-01 0.242 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 5.724878e-01 0.242 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 5.724878e-01 0.242 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 5.729199e-01 0.242 0 0
PKA activation R-HSA-163615 5.729199e-01 0.242 0 0
Mismatch Repair R-HSA-5358508 5.729199e-01 0.242 0 0
Presynaptic function of Kainate receptors R-HSA-500657 5.729199e-01 0.242 0 0
PKA activation in glucagon signalling R-HSA-164378 5.729199e-01 0.242 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 5.729199e-01 0.242 0 0
Reproduction R-HSA-1474165 5.738243e-01 0.241 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 5.743559e-01 0.241 0 0
Regulation by c-FLIP R-HSA-3371378 5.743559e-01 0.241 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 5.743559e-01 0.241 0 0
DAG1 core M2 glycosylations R-HSA-8932504 5.743559e-01 0.241 0 0
Dimerization of procaspase-8 R-HSA-69416 5.743559e-01 0.241 0 0
phospho-PLA2 pathway R-HSA-111995 5.743559e-01 0.241 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 5.743559e-01 0.241 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 5.743559e-01 0.241 0 0
FGFR1b ligand binding and activation R-HSA-190370 5.743559e-01 0.241 0 0
Adrenoceptors R-HSA-390696 5.743559e-01 0.241 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 5.743559e-01 0.241 0 0
Interleukin-18 signaling R-HSA-9012546 5.743559e-01 0.241 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 5.743559e-01 0.241 0 0
DARPP-32 events R-HSA-180024 5.760748e-01 0.240 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 5.801885e-01 0.236 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 5.823418e-01 0.235 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 5.823418e-01 0.235 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 5.838381e-01 0.234 0 0
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336 5.838381e-01 0.234 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 5.838381e-01 0.234 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 5.838381e-01 0.234 0 0
Signalling to STAT3 R-HSA-198745 5.838381e-01 0.234 0 0
Defective ABCC2 causes DJS R-HSA-5679001 5.838381e-01 0.234 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 5.838381e-01 0.234 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 5.838381e-01 0.234 0 0
Invadopodia formation R-HSA-8941237 5.838381e-01 0.234 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 5.838381e-01 0.234 0 0
Classical Kir channels R-HSA-1296053 5.838381e-01 0.234 0 0
Inhibition of nitric oxide production R-HSA-9636249 5.838381e-01 0.234 0 0
MET activates STAT3 R-HSA-8875791 5.838381e-01 0.234 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 5.838381e-01 0.234 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 5.838381e-01 0.234 0 0
Histamine receptors R-HSA-390650 5.838381e-01 0.234 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 5.970722e-01 0.224 0 0
IRE1alpha activates chaperones R-HSA-381070 5.990588e-01 0.223 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 6.031089e-01 0.220 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 6.031378e-01 0.220 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 6.039588e-01 0.219 0 0
Signaling by TGFBR3 R-HSA-9839373 6.043675e-01 0.219 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 6.061345e-01 0.217 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.061345e-01 0.217 0 0
Ion transport by P-type ATPases R-HSA-936837 6.078156e-01 0.216 0 0
CRMPs in Sema3A signaling R-HSA-399956 6.108818e-01 0.214 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 6.108818e-01 0.214 0 0
WNT mediated activation of DVL R-HSA-201688 6.214431e-01 0.207 0 0
CASP8 activity is inhibited R-HSA-5218900 6.214431e-01 0.207 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 6.214431e-01 0.207 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 6.214431e-01 0.207 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 6.214431e-01 0.207 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 6.214431e-01 0.207 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 6.258027e-01 0.204 0 0
Trafficking of AMPA receptors R-HSA-399719 6.292331e-01 0.201 0 0
Adaptive Immune System R-HSA-1280218 6.311676e-01 0.200 0 0
Tight junction interactions R-HSA-420029 6.324166e-01 0.199 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 6.324166e-01 0.199 0 0
Immune System R-HSA-168256 6.368544e-01 0.196 1 0
Metabolism of polyamines R-HSA-351202 6.448670e-01 0.191 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 6.455227e-01 0.190 0 0
SHC1 events in EGFR signaling R-HSA-180336 6.468913e-01 0.189 0 0
Telomere C-strand synthesis initiation R-HSA-174430 6.468913e-01 0.189 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 6.468913e-01 0.189 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 6.482655e-01 0.188 0 0
HCN channels R-HSA-1296061 6.507788e-01 0.187 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 6.507788e-01 0.187 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 6.507788e-01 0.187 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 6.507788e-01 0.187 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 6.507788e-01 0.187 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 6.507788e-01 0.187 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 6.507788e-01 0.187 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 6.507788e-01 0.187 0 0
NADE modulates death signalling R-HSA-205025 6.507788e-01 0.187 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 6.543008e-01 0.184 0 0
Signaling by WNT in cancer R-HSA-4791275 6.543008e-01 0.184 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 6.595879e-01 0.181 0 0
Binding and entry of HIV virion R-HSA-173107 6.643989e-01 0.178 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 6.643989e-01 0.178 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 6.643989e-01 0.178 0 0
Receptor Mediated Mitophagy R-HSA-8934903 6.643989e-01 0.178 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 6.643989e-01 0.178 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 6.643989e-01 0.178 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 6.643989e-01 0.178 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 6.643989e-01 0.178 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 6.676086e-01 0.175 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 6.676086e-01 0.175 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 6.757415e-01 0.170 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 6.782956e-01 0.169 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 6.782956e-01 0.169 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 6.804668e-01 0.167 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 6.804668e-01 0.167 0 0
Killing mechanisms R-HSA-9664420 6.804668e-01 0.167 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 6.804668e-01 0.167 0 0
Activation of SMO R-HSA-5635838 6.804668e-01 0.167 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 6.804668e-01 0.167 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 6.854260e-01 0.164 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 6.854260e-01 0.164 0 0
Cristae formation R-HSA-8949613 6.854260e-01 0.164 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 6.854260e-01 0.164 0 0
Signaling by FGFR3 in disease R-HSA-5655332 6.854260e-01 0.164 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 6.854260e-01 0.164 0 0
Signaling by FGFR2 in disease R-HSA-5655253 6.861925e-01 0.164 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 6.947602e-01 0.158 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 6.957583e-01 0.158 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 7.033338e-01 0.153 0 0
Formation of the posterior neural plate R-HSA-9832991 7.033338e-01 0.153 0 0
vRNP Assembly R-HSA-192905 7.033338e-01 0.153 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 7.069551e-01 0.151 0 0
G2 Phase R-HSA-68911 7.069551e-01 0.151 0 0
NTRK2 activates RAC1 R-HSA-9032759 7.069551e-01 0.151 0 0
FGFR1c and Klotho ligand binding and activation R-HSA-190374 7.069551e-01 0.151 0 0
Defective F9 activation R-HSA-9673221 7.069551e-01 0.151 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 7.069551e-01 0.151 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 7.069551e-01 0.151 0 0
PTK6 Down-Regulation R-HSA-8849472 7.069551e-01 0.151 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 7.069551e-01 0.151 0 0
Muscarinic acetylcholine receptors R-HSA-390648 7.069551e-01 0.151 0 0
Biosynthesis of DPAn-3-derived 13-series resolvins R-HSA-9026403 7.069551e-01 0.151 0 0
Co-inhibition by BTLA R-HSA-9927353 7.069551e-01 0.151 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 7.069551e-01 0.151 0 0
NrCAM interactions R-HSA-447038 7.069551e-01 0.151 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 7.069551e-01 0.151 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 7.069551e-01 0.151 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 7.069551e-01 0.151 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 7.099031e-01 0.149 0 0
Formation of the Early Elongation Complex R-HSA-113418 7.099031e-01 0.149 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 7.099031e-01 0.149 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 7.116079e-01 0.148 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 7.116079e-01 0.148 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 7.116079e-01 0.148 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 7.116079e-01 0.148 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 7.116079e-01 0.148 0 0
Disorders of Developmental Biology R-HSA-9675151 7.116079e-01 0.148 0 0
Passive transport by Aquaporins R-HSA-432047 7.116079e-01 0.148 0 0
Response to metal ions R-HSA-5660526 7.116079e-01 0.148 0 0
HIV Transcription Elongation R-HSA-167169 7.153726e-01 0.145 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 7.153726e-01 0.145 0 0
Selenoamino acid metabolism R-HSA-2408522 7.217183e-01 0.142 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 7.221578e-01 0.141 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 7.221578e-01 0.141 0 0
Transmission across Chemical Synapses R-HSA-112315 7.225281e-01 0.141 0 0
Signal amplification R-HSA-392518 7.229520e-01 0.141 0 0
Calnexin/calreticulin cycle R-HSA-901042 7.229520e-01 0.141 0 0
Regulation of pyruvate metabolism R-HSA-9861718 7.282997e-01 0.138 0 0
mRNA Capping R-HSA-72086 7.330081e-01 0.135 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 7.384298e-01 0.132 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 7.384298e-01 0.132 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 7.384298e-01 0.132 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 7.384298e-01 0.132 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 7.384298e-01 0.132 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 7.384298e-01 0.132 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 7.384298e-01 0.132 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 7.403535e-01 0.131 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 7.403535e-01 0.131 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 7.403535e-01 0.131 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 7.403535e-01 0.131 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 7.403535e-01 0.131 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 7.468173e-01 0.127 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 7.468173e-01 0.127 0 0
Formation of the ureteric bud R-HSA-9830674 7.468173e-01 0.127 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 7.537114e-01 0.123 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 7.540975e-01 0.123 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 7.540975e-01 0.123 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 7.540975e-01 0.123 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 7.540975e-01 0.123 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 7.540975e-01 0.123 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 7.540975e-01 0.123 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 7.540975e-01 0.123 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 7.540975e-01 0.123 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 7.540975e-01 0.123 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 7.540975e-01 0.123 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 7.540975e-01 0.123 0 0
Signaling by RNF43 mutants R-HSA-5340588 7.540975e-01 0.123 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 7.540975e-01 0.123 0 0
Signaling by MST1 R-HSA-8852405 7.540975e-01 0.123 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 7.540975e-01 0.123 0 0
Synthesis of PS R-HSA-1483101 7.540975e-01 0.123 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 7.540975e-01 0.123 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 7.540975e-01 0.123 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 7.540975e-01 0.123 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 7.540975e-01 0.123 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 7.540975e-01 0.123 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 7.547445e-01 0.122 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 7.547445e-01 0.122 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 7.630906e-01 0.117 0 0
RNA Polymerase III Transcription R-HSA-74158 7.630906e-01 0.117 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 7.630906e-01 0.117 0 0
Gluconeogenesis R-HSA-70263 7.633357e-01 0.117 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 7.667727e-01 0.115 0 0
Polo-like kinase mediated events R-HSA-156711 7.667727e-01 0.115 0 0
FGFR1 ligand binding and activation R-HSA-190242 7.667727e-01 0.115 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 7.667727e-01 0.115 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 7.667727e-01 0.115 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 7.697664e-01 0.114 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 7.697664e-01 0.114 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 7.699143e-01 0.114 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 7.699143e-01 0.114 0 0
GRB2 events in EGFR signaling R-HSA-179812 7.699143e-01 0.114 0 0
Disorders of Nervous System Development R-HSA-9697154 7.699143e-01 0.114 0 0
Pervasive developmental disorders R-HSA-9005895 7.699143e-01 0.114 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 7.699143e-01 0.114 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 7.699143e-01 0.114 0 0
Heme signaling R-HSA-9707616 7.811137e-01 0.107 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 7.909576e-01 0.102 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 7.909576e-01 0.102 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 7.909576e-01 0.102 0 0
Specification of the neural plate border R-HSA-9834899 7.909576e-01 0.102 0 0
Other interleukin signaling R-HSA-449836 7.909576e-01 0.102 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 7.910499e-01 0.102 0 0
TGFBR3 expression R-HSA-9839394 7.910499e-01 0.102 0 0
Regulation of insulin secretion R-HSA-422356 7.930807e-01 0.101 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 7.936583e-01 0.100 0 0
Metabolism of ingested MeSeO2H into MeSeH R-HSA-5263617 7.936583e-01 0.100 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 7.936583e-01 0.100 0 0
Defective CHST3 causes SEDCJD R-HSA-3595172 7.936583e-01 0.100 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 7.936583e-01 0.100 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 7.936583e-01 0.100 0 0
MET Receptor Activation R-HSA-6806942 7.936583e-01 0.100 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 7.936583e-01 0.100 0 0
G2/M DNA replication checkpoint R-HSA-69478 7.936583e-01 0.100 0 0
NADPH regeneration R-HSA-389542 7.936583e-01 0.100 0 0
VLDL assembly R-HSA-8866423 7.936583e-01 0.100 0 0
Neurofascin interactions R-HSA-447043 7.936583e-01 0.100 0 0
Innate Immune System R-HSA-168249 7.948422e-01 0.100 1 0
FGFR1c ligand binding and activation R-HSA-190373 7.980409e-01 0.098 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 7.980409e-01 0.098 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 7.980409e-01 0.098 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 7.980409e-01 0.098 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 7.987595e-01 0.098 0 0
Interferon alpha/beta signaling R-HSA-909733 8.054066e-01 0.094 0 0
MET activates PTK2 signaling R-HSA-8874081 8.107248e-01 0.091 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 8.107248e-01 0.091 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 8.107248e-01 0.091 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.107248e-01 0.091 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 8.130168e-01 0.090 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 8.130168e-01 0.090 0 0
Protein hydroxylation R-HSA-9629569 8.130168e-01 0.090 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 8.149672e-01 0.089 0 0
RAS processing R-HSA-9648002 8.149672e-01 0.089 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.149672e-01 0.089 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.153133e-01 0.089 0 0
Neuronal System R-HSA-112316 8.157619e-01 0.088 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 8.189338e-01 0.087 0 0
Prolactin receptor signaling R-HSA-1170546 8.230750e-01 0.085 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 8.230750e-01 0.085 0 0
Malate-aspartate shuttle R-HSA-9856872 8.230750e-01 0.085 0 0
HDL assembly R-HSA-8963896 8.230750e-01 0.085 0 0
Zinc transporters R-HSA-435354 8.230750e-01 0.085 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.230750e-01 0.085 0 0
Mitochondrial biogenesis R-HSA-1592230 8.244911e-01 0.084 0 0
HCMV Late Events R-HSA-9610379 8.258005e-01 0.083 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 8.268564e-01 0.083 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 8.268564e-01 0.083 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 8.268564e-01 0.083 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 8.268564e-01 0.083 0 0
Recycling of eIF2:GDP R-HSA-72731 8.268564e-01 0.083 0 0
Defective CHSY1 causes TPBS R-HSA-3595177 8.268564e-01 0.083 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 8.268564e-01 0.083 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 8.268564e-01 0.083 0 0
PTK6 Expression R-HSA-8849473 8.268564e-01 0.083 0 0
Opsins R-HSA-419771 8.268564e-01 0.083 0 0
LDL remodeling R-HSA-8964041 8.268564e-01 0.083 0 0
VLDL clearance R-HSA-8964046 8.268564e-01 0.083 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 8.268564e-01 0.083 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 8.268564e-01 0.083 0 0
CHL1 interactions R-HSA-447041 8.268564e-01 0.083 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 8.284726e-01 0.082 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 8.284726e-01 0.082 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.284726e-01 0.082 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 8.284726e-01 0.082 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 8.288575e-01 0.082 0 0
Infectious disease R-HSA-5663205 8.298708e-01 0.081 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 8.301287e-01 0.081 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 8.301287e-01 0.081 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 8.301287e-01 0.081 0 0
Diseases of Immune System R-HSA-5260271 8.301287e-01 0.081 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 8.330699e-01 0.079 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 8.330699e-01 0.079 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 8.330699e-01 0.079 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 8.330699e-01 0.079 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 8.330699e-01 0.079 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 8.330699e-01 0.079 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 8.355420e-01 0.078 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.452834e-01 0.073 0 0
G beta:gamma signalling through BTK R-HSA-8964315 8.452834e-01 0.073 0 0
Protein lipoylation R-HSA-9857492 8.452834e-01 0.073 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 8.452834e-01 0.073 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 8.452834e-01 0.073 0 0
Formation of the anterior neural plate R-HSA-9823739 8.452834e-01 0.073 0 0
DNA Damage Reversal R-HSA-73942 8.452834e-01 0.073 0 0
Telomere Extension By Telomerase R-HSA-171319 8.455214e-01 0.073 0 0
Insulin receptor recycling R-HSA-77387 8.455214e-01 0.073 0 0
Integration of energy metabolism R-HSA-163685 8.500090e-01 0.071 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 8.512430e-01 0.070 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 8.512430e-01 0.070 0 0
Aquaporin-mediated transport R-HSA-445717 8.517401e-01 0.070 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 8.547149e-01 0.068 0 0
Activation of RAS in B cells R-HSA-1169092 8.547149e-01 0.068 0 0
TGFBR3 PTM regulation R-HSA-9839383 8.547149e-01 0.068 0 0
SLC-mediated bile acid transport R-HSA-9958517 8.547149e-01 0.068 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 8.547149e-01 0.068 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 8.547149e-01 0.068 0 0
Sodium/Proton exchangers R-HSA-425986 8.547149e-01 0.068 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 8.547149e-01 0.068 0 0
Post-translational protein phosphorylation R-HSA-8957275 8.566163e-01 0.067 0 0
Translation of Structural Proteins R-HSA-9683701 8.574554e-01 0.067 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 8.575361e-01 0.067 0 0
PERK regulates gene expression R-HSA-381042 8.579638e-01 0.067 0 0
Iron uptake and transport R-HSA-917937 8.586687e-01 0.066 0 0
Translation R-HSA-72766 8.589333e-01 0.066 0 0
Platelet calcium homeostasis R-HSA-418360 8.607943e-01 0.065 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 8.610858e-01 0.065 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 8.649272e-01 0.063 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 8.649272e-01 0.063 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 8.649272e-01 0.063 0 0
Attachment and Entry R-HSA-9678110 8.649272e-01 0.063 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 8.649272e-01 0.063 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 8.676653e-01 0.062 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 8.676653e-01 0.062 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 8.709421e-01 0.060 0 0
Unfolded Protein Response (UPR) R-HSA-381119 8.717261e-01 0.060 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 8.747568e-01 0.058 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.747568e-01 0.058 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 8.773070e-01 0.057 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 8.780924e-01 0.056 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 8.780924e-01 0.056 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 8.780924e-01 0.056 0 0
mRNA Editing R-HSA-75072 8.780924e-01 0.056 0 0
Regulation of signaling by NODAL R-HSA-1433617 8.780924e-01 0.056 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 8.780924e-01 0.056 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 8.780924e-01 0.056 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 8.780924e-01 0.056 0 0
Interleukin-1 processing R-HSA-448706 8.780924e-01 0.056 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.812450e-01 0.055 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 8.822567e-01 0.054 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 8.822567e-01 0.054 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 8.824660e-01 0.054 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 8.824660e-01 0.054 0 0
Collagen chain trimerization R-HSA-8948216 8.830884e-01 0.054 0 0
Cargo concentration in the ER R-HSA-5694530 8.874910e-01 0.052 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.874910e-01 0.052 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 8.923521e-01 0.049 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 8.941568e-01 0.049 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 8.957724e-01 0.048 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.957724e-01 0.048 0 0
Plasma lipoprotein assembly R-HSA-8963898 8.957724e-01 0.048 0 0
Specification of primordial germ cells R-HSA-9827857 8.975078e-01 0.047 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.975078e-01 0.047 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 8.977093e-01 0.047 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.977093e-01 0.047 0 0
Formation of intermediate mesoderm R-HSA-9761174 8.977093e-01 0.047 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 8.977093e-01 0.047 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 8.977093e-01 0.047 0 0
Maturation of spike protein R-HSA-9683686 8.977093e-01 0.047 0 0
Peroxisomal protein import R-HSA-9033241 8.992627e-01 0.046 0 0
Amino acid transport across the plasma membrane R-HSA-352230 8.992627e-01 0.046 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.045994e-01 0.044 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.077075e-01 0.042 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.077075e-01 0.042 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.077075e-01 0.042 0 0
Formation of the nephric duct R-HSA-9830364 9.077075e-01 0.042 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.077075e-01 0.042 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 9.109007e-01 0.041 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.109007e-01 0.041 0 0
Nephron development R-HSA-9831926 9.109007e-01 0.041 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 9.109007e-01 0.041 0 0
DAG1 core M3 glycosylations R-HSA-8932505 9.141705e-01 0.039 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 9.141705e-01 0.039 0 0
Ionotropic activity of kainate receptors R-HSA-451306 9.141705e-01 0.039 0 0
vRNA Synthesis R-HSA-192814 9.141705e-01 0.039 0 0
Chylomicron assembly R-HSA-8963888 9.141705e-01 0.039 0 0
Utilization of Ketone Bodies R-HSA-77108 9.141705e-01 0.039 0 0
Biosynthesis of DPAn-3-derived maresins R-HSA-9026290 9.141705e-01 0.039 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 9.141705e-01 0.039 0 0
Dissolution of Fibrin Clot R-HSA-75205 9.141705e-01 0.039 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.147690e-01 0.039 0 0
Collagen degradation R-HSA-1442490 9.150776e-01 0.039 0 0
Disease R-HSA-1643685 9.156825e-01 0.038 0 0
Interferon gamma signaling R-HSA-877300 9.175854e-01 0.037 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.183897e-01 0.037 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.183897e-01 0.037 0 0
Synthesis of PC R-HSA-1483191 9.184560e-01 0.037 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.186436e-01 0.037 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.226384e-01 0.035 0 0
Diseases of hemostasis R-HSA-9671793 9.226384e-01 0.035 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.226384e-01 0.035 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.277575e-01 0.033 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.277575e-01 0.033 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.279310e-01 0.032 0 0
Insulin processing R-HSA-264876 9.279310e-01 0.032 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.279310e-01 0.032 0 0
DS-GAG biosynthesis R-HSA-2022923 9.279835e-01 0.032 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 9.279835e-01 0.032 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 9.279835e-01 0.032 0 0
Plasmalogen biosynthesis R-HSA-75896 9.279835e-01 0.032 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 9.279835e-01 0.032 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 9.279835e-01 0.032 0 0
Anchoring fibril formation R-HSA-2214320 9.279835e-01 0.032 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.298258e-01 0.032 0 0
Adipogenesis R-HSA-9843745 9.306716e-01 0.031 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.329066e-01 0.030 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.335248e-01 0.030 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 9.364371e-01 0.029 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.364371e-01 0.029 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 9.366016e-01 0.028 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 9.395741e-01 0.027 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 9.395741e-01 0.027 0 0
Biosynthesis of DPAn-3-derived protectins and resolvins R-HSA-9026286 9.395741e-01 0.027 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 9.395741e-01 0.027 0 0
OAS antiviral response R-HSA-8983711 9.395741e-01 0.027 0 0
G-protein activation R-HSA-202040 9.418743e-01 0.026 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.418743e-01 0.026 0 0
Triglyceride catabolism R-HSA-163560 9.425567e-01 0.026 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.425567e-01 0.026 0 0
RSV-host interactions R-HSA-9833110 9.430950e-01 0.025 0 0
Protein localization R-HSA-9609507 9.460502e-01 0.024 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.474949e-01 0.023 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.476164e-01 0.023 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.479197e-01 0.023 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.488677e-01 0.023 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 9.492998e-01 0.023 0 0
Processing of SMDT1 R-HSA-8949664 9.492998e-01 0.023 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 9.492998e-01 0.023 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 9.492998e-01 0.023 0 0
Maturation of nucleoprotein R-HSA-9683610 9.492998e-01 0.023 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 9.492998e-01 0.023 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 9.492998e-01 0.023 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.496940e-01 0.022 0 0
Mitochondrial calcium ion transport R-HSA-8949215 9.496940e-01 0.022 0 0
Ribavirin ADME R-HSA-9755088 9.496940e-01 0.022 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.496940e-01 0.022 0 0
Kidney development R-HSA-9830369 9.503776e-01 0.022 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.503776e-01 0.022 0 0
Cardiac conduction R-HSA-5576891 9.557097e-01 0.020 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.561194e-01 0.019 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.565028e-01 0.019 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.565028e-01 0.019 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 9.565028e-01 0.019 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.565028e-01 0.019 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.565028e-01 0.019 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.565028e-01 0.019 0 0
Ion channel transport R-HSA-983712 9.570076e-01 0.019 0 0
Neddylation R-HSA-8951664 9.571127e-01 0.019 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 9.574607e-01 0.019 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 9.574607e-01 0.019 0 0
Hydrolysis of LPC R-HSA-1483115 9.574607e-01 0.019 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 9.574607e-01 0.019 0 0
Formation of the active cofactor, UDP-glucuronate R-HSA-173599 9.574607e-01 0.019 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.574607e-01 0.019 0 0
Glycerophospholipid catabolism R-HSA-6814848 9.574607e-01 0.019 0 0
Acyl chain remodeling of CL R-HSA-1482798 9.574607e-01 0.019 0 0
Stimuli-sensing channels R-HSA-2672351 9.578887e-01 0.019 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.579095e-01 0.019 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.591201e-01 0.018 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.591201e-01 0.018 0 0
Mitochondrial protein import R-HSA-1268020 9.609491e-01 0.017 0 0
Translation of Structural Proteins R-HSA-9694635 9.609594e-01 0.017 0 0
Phospholipid metabolism R-HSA-1483257 9.623386e-01 0.017 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.624237e-01 0.017 0 0
Carnitine shuttle R-HSA-200425 9.624237e-01 0.017 0 0
COPII-mediated vesicle transport R-HSA-204005 9.625585e-01 0.017 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 9.643083e-01 0.016 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 9.643083e-01 0.016 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 9.643083e-01 0.016 0 0
Cardiogenesis R-HSA-9733709 9.666506e-01 0.015 0 0
Complex III assembly R-HSA-9865881 9.675658e-01 0.014 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.682045e-01 0.014 0 0
Maturation of spike protein R-HSA-9694548 9.682449e-01 0.014 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 9.700540e-01 0.013 0 0
Phase 4 - resting membrane potential R-HSA-5576886 9.700540e-01 0.013 0 0
Fructose catabolism R-HSA-70350 9.700540e-01 0.013 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 9.700540e-01 0.013 0 0
Differentiation of T cells R-HSA-9945266 9.700540e-01 0.013 0 0
Atorvastatin ADME R-HSA-9754706 9.700540e-01 0.013 0 0
Virus Assembly and Release R-HSA-168268 9.700540e-01 0.013 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.707765e-01 0.013 0 0
Heme degradation R-HSA-189483 9.707765e-01 0.013 0 0
Pyruvate metabolism R-HSA-70268 9.718177e-01 0.012 0 0
Ca2+ pathway R-HSA-4086398 9.719745e-01 0.012 0 0
G protein gated Potassium channels R-HSA-1296059 9.720266e-01 0.012 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.720266e-01 0.012 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.720266e-01 0.012 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.720266e-01 0.012 0 0
tRNA processing R-HSA-72306 9.739403e-01 0.011 0 0
Azathioprine ADME R-HSA-9748787 9.739582e-01 0.011 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.744156e-01 0.011 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.744156e-01 0.011 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.744156e-01 0.011 0 0
Glycine degradation R-HSA-6783984 9.748750e-01 0.011 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 9.748750e-01 0.011 0 0
Fibronectin matrix formation R-HSA-1566977 9.748750e-01 0.011 0 0
Coenzyme A biosynthesis R-HSA-196783 9.748750e-01 0.011 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.748750e-01 0.011 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.748750e-01 0.011 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.750511e-01 0.011 0 0
Activation of GABAB receptors R-HSA-991365 9.751247e-01 0.011 0 0
GABA B receptor activation R-HSA-977444 9.751247e-01 0.011 0 0
Sphingolipid catabolism R-HSA-9845614 9.758920e-01 0.011 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.758920e-01 0.011 0 0
TRP channels R-HSA-3295583 9.758920e-01 0.011 0 0
Triglyceride metabolism R-HSA-8979227 9.763747e-01 0.010 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.776215e-01 0.010 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.776215e-01 0.010 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.786349e-01 0.009 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 9.789201e-01 0.009 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 9.789201e-01 0.009 0 0
Catecholamine biosynthesis R-HSA-209905 9.789201e-01 0.009 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.789201e-01 0.009 0 0
Choline catabolism R-HSA-6798163 9.789201e-01 0.009 0 0
Signaling by BMP R-HSA-201451 9.792382e-01 0.009 0 0
Triglyceride biosynthesis R-HSA-75109 9.792382e-01 0.009 0 0
Synthesis of PE R-HSA-1483213 9.792382e-01 0.009 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.794680e-01 0.009 0 0
Amine ligand-binding receptors R-HSA-375280 9.805849e-01 0.009 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.816099e-01 0.008 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.821320e-01 0.008 0 0
Pyrimidine salvage R-HSA-73614 9.821320e-01 0.008 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 9.823141e-01 0.008 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.823141e-01 0.008 0 0
Integrin cell surface interactions R-HSA-216083 9.829901e-01 0.007 0 0
Interleukin-10 signaling R-HSA-6783783 9.829901e-01 0.007 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.839313e-01 0.007 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.846324e-01 0.007 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.850983e-01 0.007 0 0
Crosslinking of collagen fibrils R-HSA-2243919 9.851618e-01 0.006 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 9.851618e-01 0.006 0 0
Pyrimidine biosynthesis R-HSA-500753 9.851618e-01 0.006 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.851618e-01 0.006 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 9.851618e-01 0.006 0 0
Maturation of nucleoprotein R-HSA-9694631 9.851618e-01 0.006 0 0
G alpha (z) signalling events R-HSA-418597 9.854783e-01 0.006 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.861341e-01 0.006 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.867910e-01 0.006 0 0
SLC transporter disorders R-HSA-5619102 9.870883e-01 0.006 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.875512e-01 0.005 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.875512e-01 0.005 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.875512e-01 0.005 0 0
Pregnenolone biosynthesis R-HSA-196108 9.875512e-01 0.005 0 0
Synthesis of Ketone Bodies R-HSA-77111 9.875512e-01 0.005 0 0
Synthesis of PA R-HSA-1483166 9.885695e-01 0.005 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.891302e-01 0.005 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.891324e-01 0.005 0 0
PPARA activates gene expression R-HSA-1989781 9.891361e-01 0.005 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 9.895559e-01 0.005 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.895559e-01 0.005 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.895559e-01 0.005 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.897018e-01 0.004 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.898704e-01 0.004 0 0
DAG1 glycosylations R-HSA-8931838 9.902581e-01 0.004 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.902581e-01 0.004 0 0
HS-GAG degradation R-HSA-2024096 9.902581e-01 0.004 0 0
CS-GAG biosynthesis R-HSA-2022870 9.912379e-01 0.004 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.912379e-01 0.004 0 0
Serine metabolism R-HSA-977347 9.912379e-01 0.004 0 0
Glutathione synthesis and recycling R-HSA-174403 9.912379e-01 0.004 0 0
Intra-Golgi traffic R-HSA-6811438 9.914256e-01 0.004 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.914286e-01 0.004 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.920624e-01 0.003 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.924299e-01 0.003 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.924299e-01 0.003 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.925449e-01 0.003 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 9.926490e-01 0.003 0 0
Fructose metabolism R-HSA-5652084 9.926490e-01 0.003 0 0
Ethanol oxidation R-HSA-71384 9.926490e-01 0.003 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 9.926490e-01 0.003 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.926490e-01 0.003 0 0
Platelet homeostasis R-HSA-418346 9.927217e-01 0.003 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.928305e-01 0.003 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.928305e-01 0.003 0 0
Ketone body metabolism R-HSA-74182 9.938330e-01 0.003 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.938330e-01 0.003 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.938330e-01 0.003 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.938330e-01 0.003 0 0
Biosynthesis of maresins R-HSA-9018682 9.938330e-01 0.003 0 0
eNOS activation R-HSA-203615 9.938541e-01 0.003 0 0
Hyaluronan metabolism R-HSA-2142845 9.938541e-01 0.003 0 0
RA biosynthesis pathway R-HSA-5365859 9.938541e-01 0.003 0 0
Collagen formation R-HSA-1474290 9.939706e-01 0.003 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.947340e-01 0.002 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.948263e-01 0.002 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.951181e-01 0.002 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.952428e-01 0.002 0 0
Formation of the cornified envelope R-HSA-6809371 9.952617e-01 0.002 0 0
HS-GAG biosynthesis R-HSA-2022928 9.954899e-01 0.002 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.956597e-01 0.002 0 0
Hyaluronan degradation R-HSA-2160916 9.956597e-01 0.002 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 9.956597e-01 0.002 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.956597e-01 0.002 0 0
Laminin interactions R-HSA-3000157 9.956597e-01 0.002 0 0
Voltage gated Potassium channels R-HSA-1296072 9.961391e-01 0.002 0 0
NCAM1 interactions R-HSA-419037 9.961391e-01 0.002 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.961754e-01 0.002 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.962424e-01 0.002 0 0
Urea cycle R-HSA-70635 9.963589e-01 0.002 0 0
Metal ion SLC transporters R-HSA-425410 9.968197e-01 0.001 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.969455e-01 0.001 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 9.969455e-01 0.001 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 9.969455e-01 0.001 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.969455e-01 0.001 0 0
Pentose phosphate pathway R-HSA-71336 9.971739e-01 0.001 0 0
FCGR activation R-HSA-2029481 9.972726e-01 0.001 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.974013e-01 0.001 0 0
Iron assimilation using enterobactin R-HSA-9638334 9.974376e-01 0.001 0 0
Mitochondrial protein degradation R-HSA-9837999 9.975646e-01 0.001 0 0
GABA receptor activation R-HSA-977443 9.975994e-01 0.001 0 0
RAB geranylgeranylation R-HSA-8873719 9.975994e-01 0.001 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.976163e-01 0.001 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.978504e-01 0.001 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.978504e-01 0.001 0 0
Glucagon-type ligand receptors R-HSA-420092 9.978504e-01 0.001 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.979346e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.979379e-01 0.001 0 0
Neurotransmitter clearance R-HSA-112311 9.981968e-01 0.001 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.982353e-01 0.001 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.982718e-01 0.001 0 0
Neurotransmitter release cycle R-HSA-112310 9.984164e-01 0.001 0 0
Nucleotide biosynthesis R-HSA-8956320 9.984589e-01 0.001 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 9.984874e-01 0.001 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.984874e-01 0.001 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.986107e-01 0.001 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.987178e-01 0.001 0 0
Paracetamol ADME R-HSA-9753281 9.988504e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.988679e-01 0.000 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.989015e-01 0.000 0 0
Surfactant metabolism R-HSA-5683826 9.989015e-01 0.000 0 0
CS/DS degradation R-HSA-2024101 9.991071e-01 0.000 0 0
Dectin-2 family R-HSA-5621480 9.991439e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.992093e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.993462e-01 0.000 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.993718e-01 0.000 0 0
tRNA Aminoacylation R-HSA-379724 9.994515e-01 0.000 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.994515e-01 0.000 0 0
Glycosphingolipid transport R-HSA-9845576 9.994730e-01 0.000 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.994730e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.994763e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.994763e-01 0.000 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.995580e-01 0.000 0 0
Metabolism of folate and pterines R-HSA-196757 9.995580e-01 0.000 0 0
Elastic fibre formation R-HSA-1566948 9.996292e-01 0.000 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.996292e-01 0.000 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.996403e-01 0.000 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.996890e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.997029e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.997068e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.997356e-01 0.000 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.997392e-01 0.000 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.997392e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.997652e-01 0.000 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.997812e-01 0.000 0 0
Heme biosynthesis R-HSA-189451 9.998165e-01 0.000 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.998461e-01 0.000 0 0
Pyrimidine catabolism R-HSA-73621 9.998709e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.998784e-01 0.000 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.998917e-01 0.000 0 0
Methylation R-HSA-156581 9.998917e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.998956e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.998956e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.998956e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.999011e-01 0.000 0 0
Sialic acid metabolism R-HSA-4085001 9.999011e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999104e-01 0.000 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.999238e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.999285e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.999285e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.999340e-01 0.000 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.999361e-01 0.000 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.999464e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999466e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.999484e-01 0.000 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.999551e-01 0.000 0 0
Potassium Channels R-HSA-1296071 9.999557e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.999561e-01 0.000 0 0
The phototransduction cascade R-HSA-2514856 9.999684e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.999695e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.999731e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999776e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999798e-01 0.000 0 0
Glucuronidation R-HSA-156588 9.999814e-01 0.000 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.999844e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.999869e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.999900e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.999915e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999930e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999933e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.999935e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999978e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.999981e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.999981e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999985e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.999989e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.999991e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999992e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999992e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999995e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999998e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999998e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999998e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999998e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999999e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999999e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999999e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
G alpha (i) signalling events R-HSA-418594 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
GPCR downstream signalling R-HSA-388396 1.000000e+00 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000e+00 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 1.000000e+00 0.000 0 0
Visual phototransduction R-HSA-2187338 1.000000e+00 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 1.000000e+00 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 -0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways