LIMK2

TYR version of PSPA with Y as phospho-acceptor
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
Y Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: Y Sites / Y Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
A5A3E0 Y940 Sugiyama POTEF A26C1B ALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPEA
O14974 T696 Sugiyama PPP1R12A MBS MYPT1 EEsEsQRKARSRQARQsRRstQGVtLtDLQEAEKtIGRSRS
O43390 Y136 Sugiyama HNRNPR HNRPR QESTKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVY
O60361 Y136 Sugiyama NME2P1 SLRFKPEELVDYKSCAHDWVyE___________________
O60506 Y133 Sugiyama SYNCRIP HNRPQ NSAP1 ADSSKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVY
O60841 S182 Sugiyama EIF5B IF2 KIAA0741 DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
P00338 S161 Sugiyama LDHA PIG19 DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00338 Y172 Sugiyama LDHA PIG19 GFPKNRVIGsGCNLDsARFRyLMGERLGVHPLSCHGWVLGE
P00558 Y161 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 KAEPAKIEAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNL
P00966 Y359 Sugiyama ASS1 ASS AKSQERVEGKVQVSVLKGQVyILGRESPLSLYNEELVSMNV
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P06733 S27 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 HAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEAL
P07195 S162 Sugiyama LDHB DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07205 Y161 Sugiyama PGK2 PGKB KAEPDKIEAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNL
P07237 Y94 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB GSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFFRNGDTASPK
P07437 Y50 Sugiyama TUBB TUBB5 OK/SW-cl.56 IDPTGtyHGDsDLQLDRIsVyyNEAtGGKyVPRAILVDLEP
P07737 S30 Sugiyama PFN1 NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV
P07814 S335 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 PIEKNLQMWEEMKKGsQFGQsCCLRAKIDMSSNNGCMRDPt
P07814 Y1505 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 PLCELQPGAKCVCGKNPAKyytLFGRsy_____________
P07864 S161 Sugiyama LDHC LDH3 LDHX DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900 Y492 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DEMVsLKDYCTRMKENQKHIyyItGETKDQVANsAFVERLR
P07900 Y493 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA EMVsLKDYCTRMKENQKHIyyItGETKDQVANsAFVERLRK
P08238 S468 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB RRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItG
P08238 S497 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB KEtQKsIyyItGEsKEQVANsAFVERVRKRGFEVVyMtEPI
P08238 Y484 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DEMtsLsEyVsRMKEtQKsIyyItGEsKEQVANsAFVERVR
P08238 Y485 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB EMtsLsEyVsRMKEtQKsIyyItGEsKEQVANsAFVERVRK
P08238 Y619 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB TANMERIMKAQALRDNstMGyMMAKKHLEINPDHPIVEtLR
P09651 S360 Sugiyama HNRNPA1 HNRPA1 PyGGGGQyFAKPRNQGGyGGssssssyGsGRRF________
P10809 S488 Sugiyama HSPD1 HSP60 IKRTLKIPAMtIAKNAGVEGsLIVEKIMQSSsEVGYDAMAG
P11142 Y41 Sugiyama HSPA8 HSC70 HSP73 HSPA10 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P11940 Y194 Sugiyama PABPC1 PAB1 PABP PABP1 PABPC2 KSRKEREAELGARAKEFtNVyIKNFGEDMDDERLKDLFGKF
P13639 S38 Sugiyama EEF2 EF2 NIRNMsVIAHVDHGKStLtDsLVCKAGIIAsARAGEtRFtD
P13639 S593 Sugiyama EEF2 EF2 SDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGL
P13639 Y671 Sugiyama EEF2 EF2 CFGPDGTGPNILTDITKGVQyLNEIKDSVVAGFQWATKEGA
P14625 Y727 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 DKTVLDLAVVLFETATLRsGyLLPDTKAYGDRIERMLRLsL
P17066 Y43 Sugiyama HSPA6 HSP70B' FQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAAL
P18583 S2011 Sugiyama SON C21orf50 DBP5 KIAA1019 NREBP HSPC310 HSPC312 RSRTPSRRRRSRSVVRRRsFsIsPVRLRRSRTPLRRRFsRs
P18621 S5 Sugiyama RPL17 ________________MVRysLDPENPtKsCKSRGSNLRVH
P18621 Y4 Sugiyama RPL17 _________________MVRysLDPENPtKsCKSRGSNLRV
P19338 Y462 Sugiyama NCL AEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNSTWs
P20042 Y176 Sugiyama EIF2S2 EIF2B GIsFsNQtGPAWAGSERDytyEELLNRVFNIMREKNPDMVA
P21333 Y2379 Sugiyama FLNA FLN FLN1 GAKGAIDAKVHsPsGALEECyVtEIDQDKYAVRFIPRENGV
P22392 Y151 Sugiyama NME2 NM23B SLWFKPEELVDyKSCAHDWVyE___________________
P23528 S3 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP CFL1 CFL __________________MAsGVAVsDGVIKVFNDMKVRKs
P25398 Y127 Sugiyama RPS12 sCVVVKDYGKESQAKDVIEEyFKCKK_______________
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P27348 Y48 Sugiyama YWHAQ AVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSIEQK
P27797 S52 Sugiyama CALR CRTC GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P30101 Y100 Sugiyama PDIA3 ERP57 ERP60 GRP58 LAKVDCTANTNTCNKyGVsGyPtLKIFRDGEEAGAyDGPRt
P31946 Y50 Sugiyama YWHAB AVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSIEQK
P31947 Y48 Sugiyama SFN HME1 GAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsIEQK
P32969 S182 Sugiyama RPL9 OK/SW-cl.103; RPL9P7; RPL9P8; RPL9P9 QQATTVKNKDIRKFLDGIyVsEKGtVQQADE__________
P32969 Y180 Sugiyama RPL9 OK/SW-cl.103; RPL9P7; RPL9P8; RPL9P9 LIQQATTVKNKDIRKFLDGIyVsEKGtVQQADE________
P34931 Y43 Sugiyama HSPA1L FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P38646 S200 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 NyLGHtAKNAVItVPAyFNDsQRQAtKDAGQIsGLNVLRVI
P39019 Y54 Sugiyama RPS19 VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P40227 S246 Sugiyama CCT6A CCT6 CCTZ EDAyILTCNVSLEYEKTEVNsGFFyKSAEEREKLVKAERKF
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P46108 S41 Sugiyama CRK QEAVALLQGQRHGVFLVRDsstsPGDyVLSVSENSRVSHYI
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46777 S176 Sugiyama RPL5 MSTP030 GNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHR
P48741 Y43 Sugiyama HSPA7 HSP70B FQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAAL
P49207 Y32 Sugiyama RPL34 sYNtASNKTRLSRTPGNRIVyLytKKVGKAPKSACGVCPGR
P49207 Y34 Sugiyama RPL34 NtASNKTRLSRTPGNRIVyLytKKVGKAPKSACGVCPGRLR
P49840 Y279 Sugiyama GSK3A LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P49841 Y216 Sugiyama GSK3B LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P50395 S396 Sugiyama GDI2 RABGDIB IEQKFVsISDLLVPKDLGtEsQIFIsRTyDAttHFEttCDD
P53671 S100 Sugiyama LIMK2 TGPFMVAGEFKYHPECFACMsCKVIIEDGDAYALVQHATLY
P53671 S22 Sugiyama LIMK2 SALAGEDVWRCPGCGDHIAPsQIWyRTVNETWHGsCFRCSE
P53671 S36 Sugiyama LIMK2 GDHIAPsQIWyRTVNETWHGsCFRCSECQDSLTNWyyEKDG
P53671 T278 Sugiyama LIMK2 QNAGHPHALSTLDTKENLEGtLRRRsLRRsNsIsKsPGPss
P53671 Y26 Sugiyama LIMK2 GEDVWRCPGCGDHIAPsQIWyRTVNETWHGsCFRCSECQDS
P53671 Y51 Sugiyama LIMK2 ETWHGsCFRCSECQDSLTNWyyEKDGKLYCPKDYWGKFGEF
P53671 Y52 Sugiyama LIMK2 TWHGsCFRCSECQDSLTNWyyEKDGKLYCPKDYWGKFGEFC
P54652 Y42 Sugiyama HSPA2 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 Y240 Sugiyama ACTB ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P60981 S3 EPSD|PSP DSTN ACTDP DSN __________________MAsGVQVADEVCRIFYDMKVRKC
P61313 Y6 Sugiyama RPL15 EC45 TCBAP0781 _______________MGAYKyIQELWRKKQSDVMRFLLRVR
P61981 Y49 Sugiyama YWHAG NVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSIEQK
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 Y49 Sugiyama YWHAE KVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssIEQK
P62269 Y95 Sugiyama RPS18 D6S218E RQYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLK
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 Y242 Sugiyama ACTA2 ACTSA ACTVS GIG46 ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P62750 Y144 Sugiyama RPL23A VNtLIRPDGEKKAYVRLAPDyDALDVANKIGII________
P62826 Y146 Sugiyama RAN ARA24 OK/SW-cl.81 IKDRKVKAKsIVFHRKKNLQyyDIsAKSNyNFEKPFLWLAR
P62979 Y148 Sugiyama RPS27A UBA80 UBCEP1 AGVFMAsHFDRHyCGKCCLtyCFNKPEDK____________
P63104 Y48 Sugiyama YWHAZ sVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssIEQK
P63220 Y53 Sugiyama RPS21 QMNVAEVDKVTGRFNGQFKtyAICGAIRRMGEsDDsILRLA
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 Y240 Sugiyama ACTG1 ACTG ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 Y241 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P67809 Y196 Sugiyama YBX1 NSEP1 YB1 sAPEGQAQQRRPyRRRRFPPyyMRRPYGRRPQysNPPVQGE
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 Y242 Sugiyama ACTC1 ACTC ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68104 Y29 Sugiyama EEF1A1 EEF1A EF1A LENG7 NIVVIGHVDsGKstttGHLIyKCGGIDKRTIEKFEKEAAEM
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 Y242 Sugiyama ACTA1 ACTA ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
Q00839 Y257 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 QKGGDKKRGVKRPREDHGRGyFEyIEENKysRAKsPQPPVE
Q00839 Y260 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 GDKKRGVKRPREDHGRGyFEyIEENKysRAKsPQPPVEEED
Q04917 Y49 Sugiyama YWHAH YWHA1 AVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSIEQK
Q05639 Y29 Sugiyama EEF1A2 EEF1AL STN NIVVIGHVDsGKstttGHLIyKCGGIDKRTIEKFEKEAAEM
Q06830 S32 Sugiyama PRDX1 PAGA PAGB TDPX2 APNFKAtAVMPDGQFKDIsLsDyKGKYVVFFFYPLDFTFVC
Q06830 Y116 Sugiyama PRDX1 PAGA PAGB TDPX2 GLGPMNIPLVSDPKRtIAQDyGVLKADEGIsFRGLFIIDDK
Q13263 Y133 Sugiyama TRIM28 KAP1 RNF96 TIF1B TVVDCPVCKQQCFSKDIVENyFMRDsGsKAATDAQDANQCC
Q13283 Y125 Sugiyama G3BP1 G3BP LRRFMQtFVLAPEGsVANKFyVHNDIFRyQDEVFGGFVtEP
Q13310 Y194 Sugiyama PABPC4 APP1 PABP4 KSRKEREAELGAKAKEFtNVyIKNFGEEVDDEsLKELFsQF
Q13765 Y120 Sugiyama NACA HSD48 KNILFVITKPDVYKSPAsDtyIVFGEAKIEDLsQQAQLAAA
Q15080 S67 Sugiyama NCF4 SH3PXD4 TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q15185 S72 Sugiyama PTGES3 P23 TEBP EIDLFHCIDPNDsKHKRtDRsILCCLRKGEsGQsWPRLTKE
Q562R1 Y241 Sugiyama ACTBL2 ALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPEA
Q58FF7 S370 Sugiyama HSP90AB3P HSP90BC KETQKSTYYITGESKEQVANsAFVERVRKQGFEVVYMTEPI
Q58FF7 Y492 Sugiyama HSP90AB3P HSP90BC TANMEQIMKAQALRDNstMGyMMAKKHLEINPDHPIMETLR
Q58FF8 Y260 Sugiyama HSP90AB2P HSP90BB VRYFSVEEYVSRMKEIQKsIyyItGEsKEQVANSAFVEQVW
Q58FF8 Y261 Sugiyama HSP90AB2P HSP90BB RYFSVEEYVSRMKEIQKsIyyItGEsKEQVANSAFVEQVWK
Q58FG0 Y177 Sugiyama HSP90AA5P HSP90AE GQLEELKDSRRVMKANQKHIyyItGETKDQVANSAFVECLQ
Q58FG0 Y178 Sugiyama HSP90AA5P HSP90AE QLEELKDSRRVMKANQKHIyyItGETKDQVANSAFVECLQK
Q5VTE0 Y29 Sugiyama EEF1A1P5 EEF1AL3 NIVVIGHVDsGKstttGHLIyKCGGIDKRTIEKFEKEAAEM
Q6S8J3 Y940 Sugiyama POTEE A26C1A POTE2 ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
Q6ZMR3 S161 Sugiyama LDHAL6A LDHL2 DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q92526 S246 Sugiyama CCT6B EDAFILICNVSLEYEKTEVNsGFFyKTAEEKEKLVKAERKF
Q9BYX7 Y240 Sugiyama POTEKP ACTBL3 FKSG30 ALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPEA
Q9Y3D8 Y31 Sugiyama AK6 CINAP AD-004 CGI-137 TPGVGKTTLGKELASKSGLKyINVGDLAREEQLYDGYDEEY
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Interleukin-1 family signaling R-HSA-446652 0.000002 5.745 0 0
Signaling by Interleukins R-HSA-449147 0.000040 4.400 0 0
Interleukin-37 signaling R-HSA-9008059 0.000040 4.400 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 0.000051 4.290 0 0
mRNA Splicing - Major Pathway R-HSA-72163 0.000080 4.098 0 0
mRNA Splicing R-HSA-72172 0.000120 3.921 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 0.000191 3.719 0 0
Immune System R-HSA-168256 0.000271 3.567 0 0
Apoptotic execution phase R-HSA-75153 0.000261 3.584 0 0
Cytokine Signaling in Immune system R-HSA-1280215 0.000357 3.447 0 0
Innate Immune System R-HSA-168249 0.000620 3.208 0 0
Signal regulatory protein family interactions R-HSA-391160 0.000897 3.047 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 0.001123 2.950 0 0
Interleukin-1 signaling R-HSA-9020702 0.001130 2.947 0 0
Signal Transduction R-HSA-162582 0.001051 2.978 1 0
Interleukin-2 family signaling R-HSA-451927 0.001487 2.828 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 0.001804 2.744 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 0.002294 2.639 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 0.002294 2.639 0 0
Germ layer formation at gastrulation R-HSA-9754189 0.002033 2.692 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 0.002290 2.640 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 0.002362 2.627 0 0
Death Receptor Signaling R-HSA-73887 0.002129 2.672 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 0.002660 2.575 0 0
Apoptosis R-HSA-109581 0.002736 2.563 0 0
Signaling by VEGF R-HSA-194138 0.003415 2.467 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 0.006079 2.216 0 0
Parasite infection R-HSA-9664407 0.005900 2.229 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 0.005900 2.229 0 0
Leishmania phagocytosis R-HSA-9664417 0.005900 2.229 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 0.005864 2.232 0 0
Axon guidance R-HSA-422475 0.005816 2.235 1 0
p75 NTR receptor-mediated signalling R-HSA-193704 0.005793 2.237 0 0
Drug resistance of ALK mutants R-HSA-9700649 0.010195 1.992 0 0
brigatinib-resistant ALK mutants R-HSA-9717319 0.010195 1.992 0 0
alectinib-resistant ALK mutants R-HSA-9717316 0.010195 1.992 0 0
NVP-TAE684-resistant ALK mutants R-HSA-9717301 0.010195 1.992 0 0
lorlatinib-resistant ALK mutants R-HSA-9717329 0.010195 1.992 0 0
ceritinib-resistant ALK mutants R-HSA-9717323 0.010195 1.992 0 0
crizotinib-resistant ALK mutants R-HSA-9717326 0.010195 1.992 0 0
ASP-3026-resistant ALK mutants R-HSA-9717264 0.010195 1.992 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 0.008932 2.049 0 0
DAP12 signaling R-HSA-2424491 0.006274 2.202 0 0
GPVI-mediated activation cascade R-HSA-114604 0.010152 1.993 0 0
Signaling by ALK in cancer R-HSA-9700206 0.007982 2.098 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 0.008347 2.078 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 0.009310 2.031 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 0.006415 2.193 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 0.007982 2.098 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 0.009530 2.021 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 0.007653 2.116 0 0
Nervous system development R-HSA-9675108 0.009595 2.018 1 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 0.006932 2.159 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 0.008847 2.053 0 0
Metabolism of RNA R-HSA-8953854 0.007131 2.147 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 0.009638 2.016 0 0
ChREBP activates metabolic gene expression R-HSA-163765 0.009310 2.031 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 0.009601 2.018 0 0
Programmed Cell Death R-HSA-5357801 0.008942 2.049 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 0.011999 1.921 0 0
p75NTR recruits signalling complexes R-HSA-209543 0.011999 1.921 0 0
Signaling by ALK R-HSA-201556 0.012156 1.915 0 0
RAF/MAP kinase cascade R-HSA-5673001 0.014931 1.826 0 0
Ub-specific processing proteases R-HSA-5689880 0.014794 1.830 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 0.016586 1.780 0 0
p75NTR signals via NF-kB R-HSA-193639 0.016586 1.780 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 0.016586 1.780 0 0
Proteasome assembly R-HSA-9907900 0.016801 1.775 0 0
DAP12 interactions R-HSA-2172127 0.016801 1.775 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 0.016838 1.774 0 0
XBP1(S) activates chaperone genes R-HSA-381038 0.017054 1.768 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 0.020286 1.693 0 0
IRE1alpha activates chaperones R-HSA-381070 0.020798 1.682 0 0
Nef mediated downregulation of CD28 cell surface expression R-HSA-164939 0.030275 1.519 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 0.030275 1.519 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 0.030275 1.519 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 0.030275 1.519 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 0.030275 1.519 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 0.030275 1.519 0 0
Formation of definitive endoderm R-HSA-9823730 0.027595 1.559 0 0
Negative regulation of MET activity R-HSA-6807004 0.027595 1.559 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 0.023311 1.632 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 0.029651 1.528 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 0.023668 1.626 0 0
Inhibition of membrane repair R-HSA-9635644 0.030275 1.519 0 0
Toll-like Receptor Cascades R-HSA-168898 0.021854 1.660 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 0.026520 1.576 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 0.026520 1.576 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 0.026520 1.576 0 0
Other interleukin signaling R-HSA-449836 0.025601 1.592 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 0.031552 1.501 0 0
Gastrulation R-HSA-9758941 0.029562 1.529 0 0
Regulation of CDH1 Function R-HSA-9764561 0.029831 1.525 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 0.025010 1.602 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 0.027595 1.559 0 0
Polo-like kinase mediated events R-HSA-156711 0.023668 1.626 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 0.023668 1.626 0 0
Signaling by ROBO receptors R-HSA-376176 0.027654 1.558 0 0
Deubiquitination R-HSA-5688426 0.024013 1.620 0 0
Uptake and function of anthrax toxins R-HSA-5210891 0.021798 1.662 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 0.027654 1.558 0 0
Cellular responses to stimuli R-HSA-8953897 0.030622 1.514 0 0
Cellular response to chemical stress R-HSA-9711123 0.029788 1.526 0 0
Cell-Cell communication R-HSA-1500931 0.023248 1.634 0 0
Unfolded Protein Response (UPR) R-HSA-381119 0.022957 1.639 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 0.031765 1.498 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 0.031765 1.498 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 0.040162 1.396 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 0.040162 1.396 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 0.040162 1.396 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 0.040162 1.396 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 0.040162 1.396 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 0.040162 1.396 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 0.040162 1.396 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 0.040162 1.396 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 0.040162 1.396 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 0.040162 1.396 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 0.040162 1.396 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 0.040162 1.396 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 0.040162 1.396 0 0
MET interacts with TNS proteins R-HSA-8875513 0.049950 1.301 0 0
Axonal growth stimulation R-HSA-209563 0.049950 1.301 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 0.049950 1.301 0 0
Invadopodia formation R-HSA-8941237 0.049950 1.301 0 0
MET activates PTPN11 R-HSA-8865999 0.049950 1.301 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 0.059638 1.224 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 0.078721 1.104 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 0.078721 1.104 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 0.078721 1.104 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 0.097419 1.011 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 0.097419 1.011 0 0
Recycling of eIF2:GDP R-HSA-72731 0.097419 1.011 0 0
DAG1 core M1 glycosylations R-HSA-8932506 0.097419 1.011 0 0
DAG1 core M2 glycosylations R-HSA-8932504 0.106626 0.972 0 0
MET receptor recycling R-HSA-8875656 0.106626 0.972 0 0
Interleukin-21 signaling R-HSA-9020958 0.115740 0.937 0 0
ALK mutants bind TKIs R-HSA-9700645 0.115740 0.937 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 0.124761 0.904 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 0.124761 0.904 0 0
DAG1 core M3 glycosylations R-HSA-8932505 0.133691 0.874 0 0
Interleukin receptor SHC signaling R-HSA-912526 0.036165 1.442 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 0.142531 0.846 0 0
MET activates PTK2 signaling R-HSA-8874081 0.043174 1.365 0 0
MET activates RAS signaling R-HSA-8851805 0.151280 0.820 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 0.151280 0.820 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 0.151280 0.820 0 0
Cristae formation R-HSA-8949613 0.045613 1.341 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 0.185400 0.732 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 0.193715 0.713 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 0.193715 0.713 0 0
MET promotes cell motility R-HSA-8875878 0.078424 1.106 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 0.106541 0.972 0 0
mRNA 3'-end processing R-HSA-72187 0.126556 0.898 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 0.129974 0.886 0 0
Signaling by MET R-HSA-6806834 0.062639 1.203 0 0
CD28 dependent Vav1 pathway R-HSA-389359 0.159941 0.796 0 0
DCC mediated attractive signaling R-HSA-418885 0.177000 0.752 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 0.075466 1.122 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 0.140354 0.853 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 0.033937 1.469 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 0.193715 0.713 0 0
MDK and PTN in ALK signaling R-HSA-9851151 0.059638 1.224 0 0
Neutrophil degranulation R-HSA-6798695 0.058773 1.231 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 0.048103 1.318 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 0.069228 1.160 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 0.106626 0.972 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 0.142531 0.846 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 0.054491 1.264 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 0.093732 1.028 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 0.069228 1.160 0 0
MET Receptor Activation R-HSA-6806942 0.088118 1.055 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 0.177000 0.752 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 0.193715 0.713 0 0
Co-stimulation by CD28 R-HSA-389356 0.113113 0.946 0 0
Complex IV assembly R-HSA-9864848 0.123160 0.910 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 0.036985 1.432 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 0.049950 1.301 0 0
MET activates STAT3 R-HSA-8875791 0.049950 1.301 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 0.078721 1.104 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 0.078721 1.104 0 0
Fructose biosynthesis R-HSA-5652227 0.106626 0.972 0 0
p75NTR regulates axonogenesis R-HSA-193697 0.115740 0.937 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 0.124761 0.904 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 0.151280 0.820 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 0.048103 1.318 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 0.055858 1.253 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 0.193715 0.713 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 0.106541 0.972 0 0
FCERI mediated MAPK activation R-HSA-2871796 0.039574 1.403 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 0.092169 1.035 0 0
Mitophagy R-HSA-5205647 0.066819 1.175 0 0
Generation of second messenger molecules R-HSA-202433 0.084446 1.073 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 0.193715 0.713 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 0.147299 0.832 0 0
Cellular response to hypoxia R-HSA-1234174 0.039863 1.399 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 0.193715 0.713 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 0.100311 0.999 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 0.194448 0.711 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 0.147299 0.832 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 0.142531 0.846 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 0.193715 0.713 0 0
Separation of Sister Chromatids R-HSA-2467813 0.118268 0.927 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 0.190755 0.720 0 0
Pyrophosphate hydrolysis R-HSA-71737 0.069228 1.160 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 0.106626 0.972 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 0.115740 0.937 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 0.058534 1.233 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 0.069663 1.157 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 0.069663 1.157 0 0
Degradation of CRY and PER proteins R-HSA-9932298 0.090604 1.043 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 0.090604 1.043 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 0.109814 0.959 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 0.126556 0.898 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 0.129974 0.886 0 0
Signaling by Activin R-HSA-1502540 0.177000 0.752 0 0
Respiratory electron transport R-HSA-611105 0.145137 0.838 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 0.036717 1.435 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 0.088118 1.055 0 0
Myogenesis R-HSA-525793 0.043174 1.365 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 0.151280 0.820 0 0
Degradation of DVL R-HSA-4641258 0.075466 1.122 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 0.048885 1.311 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 0.048885 1.311 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 0.052235 1.282 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 0.052235 1.282 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 0.040553 1.392 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 0.043575 1.361 0 0
Cell Cycle Checkpoints R-HSA-69620 0.067727 1.169 0 0
Co-inhibition by BTLA R-HSA-9927353 0.069228 1.160 0 0
WNT mediated activation of DVL R-HSA-201688 0.115740 0.937 0 0
Regulation of IFNG signaling R-HSA-877312 0.151280 0.820 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 0.151280 0.820 0 0
Interaction between L1 and Ankyrins R-HSA-445095 0.045613 1.341 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 0.177000 0.752 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 0.072545 1.139 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 0.072545 1.139 0 0
Degradation of AXIN R-HSA-4641257 0.075466 1.122 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 0.075466 1.122 0 0
Orc1 removal from chromatin R-HSA-68949 0.126556 0.898 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 0.133414 0.875 0 0
EPH-Ephrin signaling R-HSA-2682334 0.088206 1.055 1 0
RNA Polymerase II Transcription Termination R-HSA-73856 0.158025 0.801 0 0
COPII-mediated vesicle transport R-HSA-204005 0.190755 0.720 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 0.108191 0.966 0 0
G2/M Transition R-HSA-69275 0.060971 1.215 0 0
Mitotic G2-G2/M phases R-HSA-453274 0.063003 1.201 0 0
Nef and signal transduction R-HSA-164944 0.088118 1.055 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 0.036165 1.442 0 0
Vpu mediated degradation of CD4 R-HSA-180534 0.064015 1.194 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 0.066819 1.175 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 0.066819 1.175 0 0
Regulation of Apoptosis R-HSA-169911 0.069663 1.157 0 0
Synthesis of PG R-HSA-1483148 0.193715 0.713 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 0.090604 1.043 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 0.090604 1.043 0 0
Regulation of RAS by GAPs R-HSA-5658442 0.119787 0.922 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 0.126556 0.898 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 0.069541 1.158 0 0
Platelet activation, signaling and aggregation R-HSA-76002 0.032745 1.485 0 0
Leishmania infection R-HSA-9658195 0.036436 1.438 0 0
Parasitic Infection Pathways R-HSA-9824443 0.036436 1.438 0 0
MAP kinase activation R-HSA-450294 0.158025 0.801 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 0.155111 0.809 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 0.037656 1.424 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 0.185400 0.732 0 0
ER-Phagosome pathway R-HSA-1236974 0.080505 1.094 0 0
MyD88-independent TLR4 cascade R-HSA-166166 0.037656 1.424 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 0.033100 1.480 0 0
Signaling by ERBB2 R-HSA-1227986 0.154457 0.811 0 0
TCR signaling R-HSA-202403 0.037656 1.424 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 0.057497 1.240 0 0
Interleukin-17 signaling R-HSA-448424 0.190755 0.720 0 0
Cellular response to mitochondrial stress R-HSA-9840373 0.115740 0.937 0 0
Galactose catabolism R-HSA-70370 0.193715 0.713 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 0.084446 1.073 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 0.087509 1.058 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 0.087509 1.058 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 0.129974 0.886 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 0.132312 0.878 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 0.087509 1.058 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 0.136874 0.864 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 0.167646 0.776 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 0.035793 1.446 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 0.194448 0.711 0 0
Regulation of mitotic cell cycle R-HSA-453276 0.194448 0.711 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 0.115740 0.937 0 0
PECAM1 interactions R-HSA-210990 0.133691 0.874 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 0.081418 1.089 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 0.081418 1.089 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 0.096890 1.014 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 0.100078 1.000 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 0.103296 0.986 0 0
NRAGE signals death through JNK R-HSA-193648 0.140354 0.853 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 0.053379 1.273 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 0.140354 0.853 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 0.100311 0.999 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 0.159941 0.796 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 0.168514 0.773 0 0
Regulation of KIT signaling R-HSA-1433559 0.168514 0.773 0 0
RUNX2 regulates bone development R-HSA-8941326 0.072545 1.139 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 0.103296 0.986 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 0.140354 0.853 0 0
TNF signaling R-HSA-75893 0.140354 0.853 0 0
Antigen processing-Cross presentation R-HSA-1236975 0.126352 0.898 0 0
Ion transport by P-type ATPases R-HSA-936837 0.168820 0.773 0 0
FOXO-mediated transcription R-HSA-9614085 0.104487 0.981 0 0
Response of endothelial cells to shear stress R-HSA-9860931 0.115221 0.938 0 0
Circadian clock R-HSA-9909396 0.066854 1.175 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 0.084446 1.073 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 0.087509 1.058 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 0.103296 0.986 0 0
Host Interactions of HIV factors R-HSA-162909 0.054536 1.263 0 0
S Phase R-HSA-69242 0.092317 1.035 0 0
Interleukin-2 signaling R-HSA-9020558 0.133691 0.874 0 0
Formation of the nephric duct R-HSA-9830364 0.040785 1.390 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 0.158025 0.801 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 0.106626 0.972 0 0
Heme biosynthesis R-HSA-189451 0.090604 1.043 0 0
Degradation of CDH1 R-HSA-9766229 0.116438 0.934 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 0.123160 0.910 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 0.161609 0.792 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 0.063018 1.201 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 0.140194 0.853 0 0
MAPK family signaling cascades R-HSA-5683057 0.036312 1.440 0 0
Amino acid transport across the plasma membrane R-HSA-352230 0.150906 0.821 0 0
SARS-CoV-1-host interactions R-HSA-9692914 0.033984 1.469 0 0
SLC-mediated transport of amino acids R-HSA-9958863 0.179735 0.745 0 0
G2/M Checkpoints R-HSA-69481 0.179347 0.746 0 0
G1/S Transition R-HSA-69206 0.056892 1.245 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 0.147371 0.832 0 0
Kidney development R-HSA-9830369 0.179735 0.745 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 0.043174 1.365 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 0.049865 1.302 0 0
Regulation of PTEN stability and activity R-HSA-8948751 0.129974 0.886 0 0
G0 and Early G1 R-HSA-1538133 0.058534 1.233 0 0
ABC-family proteins mediated transport R-HSA-382556 0.106601 0.972 0 0
Regulation of TNFR1 signaling R-HSA-5357905 0.106541 0.972 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 0.161609 0.792 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 0.096890 1.014 0 0
Stabilization of p53 R-HSA-69541 0.081418 1.089 0 0
Hedgehog ligand biogenesis R-HSA-5358346 0.123160 0.910 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 0.190755 0.720 0 0
Cellular responses to stress R-HSA-2262752 0.068231 1.166 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 0.113113 0.946 0 0
Infectious disease R-HSA-5663205 0.158352 0.800 0 0
Metabolism of polyamines R-HSA-351202 0.154457 0.811 0 0
SARS-CoV Infections R-HSA-9679506 0.138969 0.857 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 0.066819 1.175 0 0
L1CAM interactions R-HSA-373760 0.149694 0.825 0 0
Hedgehog 'on' state R-HSA-5632684 0.194448 0.711 0 0
Somitogenesis R-HSA-9824272 0.103296 0.986 0 0
Signaling by SCF-KIT R-HSA-1433557 0.096890 1.014 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 0.159941 0.796 0 0
Metabolism of porphyrins R-HSA-189445 0.194448 0.711 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 0.154520 0.811 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 0.116438 0.934 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 0.116438 0.934 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 0.126556 0.898 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 0.190755 0.720 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 0.135927 0.867 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 0.135927 0.867 0 0
Intracellular signaling by second messengers R-HSA-9006925 0.080315 1.095 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 0.096955 1.013 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 0.168514 0.773 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 0.110051 0.958 0 0
Formation of paraxial mesoderm R-HSA-9793380 0.158025 0.801 0 0
Cell-cell junction organization R-HSA-421270 0.147121 0.832 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 0.180178 0.744 0 0
SARS-CoV-1 Infection R-HSA-9678108 0.050475 1.297 0 0
Cell junction organization R-HSA-446728 0.192276 0.716 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 0.126556 0.898 0 0
PIP3 activates AKT signaling R-HSA-1257604 0.106551 0.972 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 0.201863 0.695 0 0
Switching of origins to a post-replicative state R-HSA-69052 0.201863 0.695 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 0.201863 0.695 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 0.201945 0.695 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 0.201945 0.695 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 0.201945 0.695 0 0
Signaling by Hippo R-HSA-2028269 0.201945 0.695 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 0.201945 0.695 0 0
Signaling by NOTCH4 R-HSA-9013694 0.205582 0.687 0 0
Ephrin signaling R-HSA-3928664 0.210092 0.678 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 0.210092 0.678 0 0
Platelet sensitization by LDL R-HSA-432142 0.210092 0.678 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 0.210439 0.677 0 0
UCH proteinases R-HSA-5689603 0.213043 0.672 0 0
STING mediated induction of host immune responses R-HSA-1834941 0.218156 0.661 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 0.218156 0.661 0 0
G alpha (12/13) signalling events R-HSA-416482 0.220530 0.657 0 0
ABC transporter disorders R-HSA-5619084 0.220530 0.657 0 0
PCP/CE pathway R-HSA-4086400 0.220530 0.657 0 0
Mitotic Anaphase R-HSA-68882 0.224177 0.649 0 0
Sensory processing of sound R-HSA-9659379 0.224282 0.649 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 0.226139 0.646 0 0
Signaling by NODAL R-HSA-1181150 0.226139 0.646 0 0
Signal transduction by L1 R-HSA-445144 0.226139 0.646 0 0
Creatine metabolism R-HSA-71288 0.226139 0.646 0 0
Pregnenolone biosynthesis R-HSA-196108 0.226139 0.646 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 0.226340 0.645 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 0.226410 0.645 0 0
PKR-mediated signaling R-HSA-9833482 0.228038 0.642 0 0
Adherens junctions interactions R-HSA-418990 0.228510 0.641 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 0.234040 0.631 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 0.234040 0.631 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 0.234040 0.631 0 0
Basigin interactions R-HSA-210991 0.234040 0.631 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 0.234040 0.631 0 0
Interferon Signaling R-HSA-913531 0.235267 0.628 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 0.235565 0.628 0 0
Cytoprotection by HMOX1 R-HSA-9707564 0.239333 0.621 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 0.239333 0.621 0 0
ER to Golgi Anterograde Transport R-HSA-199977 0.239895 0.620 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 0.241861 0.616 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 0.241861 0.616 0 0
Attachment and Entry R-HSA-9694614 0.241861 0.616 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 0.241861 0.616 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 0.246880 0.608 0 0
Potential therapeutics for SARS R-HSA-9679191 0.248050 0.605 0 0
HIV Infection R-HSA-162906 0.248260 0.605 0 0
FGFR2 alternative splicing R-HSA-6803529 0.249603 0.603 0 0
Fructose metabolism R-HSA-5652084 0.249603 0.603 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 0.249603 0.603 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 0.249603 0.603 0 0
Amplification of signal from the kinetochores R-HSA-141424 0.250656 0.601 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 0.250656 0.601 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 0.250656 0.601 0 0
Cell Cycle, Mitotic R-HSA-69278 0.255485 0.593 0 0
Syndecan interactions R-HSA-3000170 0.257266 0.590 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 0.257266 0.590 0 0
Formation of the ureteric bud R-HSA-9830674 0.257266 0.590 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 0.257266 0.590 0 0
Growth hormone receptor signaling R-HSA-982772 0.257266 0.590 0 0
Interleukin-20 family signaling R-HSA-8854691 0.257266 0.590 0 0
Selective autophagy R-HSA-9663891 0.261994 0.582 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 0.264852 0.577 0 0
Complex III assembly R-HSA-9865881 0.264852 0.577 0 0
Neurodegenerative Diseases R-HSA-8863678 0.264852 0.577 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 0.264852 0.577 0 0
Downstream TCR signaling R-HSA-202424 0.269556 0.569 0 0
Sema4D in semaphorin signaling R-HSA-400685 0.272360 0.565 1 0
VEGFR2 mediated cell proliferation R-HSA-5218921 0.272360 0.565 0 0
Tight junction interactions R-HSA-420029 0.272360 0.565 0 0
TGFBR3 expression R-HSA-9839394 0.272360 0.565 0 0
Interferon gamma signaling R-HSA-877300 0.272753 0.564 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 0.273337 0.563 0 0
Signaling by TGFB family members R-HSA-9006936 0.275516 0.560 0 0
Signaling by NOTCH R-HSA-157118 0.277401 0.557 0 0
Suppression of phagosomal maturation R-HSA-9637687 0.279792 0.553 0 0
Developmental Biology R-HSA-1266738 0.282466 0.549 1 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 0.284673 0.546 0 0
Assembly of the pre-replicative complex R-HSA-68867 0.284673 0.546 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 0.287149 0.542 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 0.287149 0.542 0 0
Signaling by BMP R-HSA-201451 0.287149 0.542 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 0.287149 0.542 0 0
Maturation of hRSV A proteins R-HSA-9828806 0.287149 0.542 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 0.287149 0.542 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 0.294431 0.531 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 0.295993 0.529 0 0
Adaptive Immune System R-HSA-1280218 0.299913 0.523 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 0.301639 0.521 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 0.301639 0.521 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 0.301639 0.521 0 0
Signaling by Erythropoietin R-HSA-9006335 0.301639 0.521 0 0
DARPP-32 events R-HSA-180024 0.301639 0.521 0 0
RNA Polymerase II Transcription R-HSA-73857 0.304519 0.516 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 0.306063 0.514 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 0.308774 0.510 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 0.308774 0.510 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 0.308774 0.510 0 0
Hemostasis R-HSA-109582 0.312126 0.506 0 0
Mitotic Spindle Checkpoint R-HSA-69618 0.314799 0.502 0 0
Hedgehog 'off' state R-HSA-5610787 0.314799 0.502 0 0
Downstream signal transduction R-HSA-186763 0.315836 0.501 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 0.315836 0.501 0 0
EGFR downregulation R-HSA-182971 0.315836 0.501 0 0
Cargo concentration in the ER R-HSA-5694530 0.315836 0.501 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 0.315836 0.501 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 0.315836 0.501 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 0.315836 0.501 0 0
Disease R-HSA-1643685 0.316643 0.499 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 0.322292 0.492 0 0
DAG1 glycosylations R-HSA-8931838 0.322827 0.491 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 0.322827 0.491 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 0.322827 0.491 0 0
HS-GAG degradation R-HSA-2024096 0.322827 0.491 0 0
SARS-CoV-2 Infection R-HSA-9694516 0.327955 0.484 0 0
Integrin signaling R-HSA-354192 0.329747 0.482 0 0
Nuclear RNA decay R-HSA-9930044 0.329747 0.482 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 0.329747 0.482 0 0
Activation of ATR in response to replication stress R-HSA-176187 0.329747 0.482 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 0.329747 0.482 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 0.329747 0.482 0 0
Cardiogenesis R-HSA-9733709 0.329747 0.482 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 0.329747 0.482 0 0
Opioid Signalling R-HSA-111885 0.329766 0.482 0 0
RSV-host interactions R-HSA-9833110 0.333494 0.477 0 0
Effects of PIP2 hydrolysis R-HSA-114508 0.336596 0.473 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 0.336596 0.473 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 0.336596 0.473 0 0
TCF dependent signaling in response to WNT R-HSA-201681 0.342325 0.466 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 0.343376 0.464 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 0.343376 0.464 0 0
NOD1/2 Signaling Pathway R-HSA-168638 0.343376 0.464 0 0
Synthesis of DNA R-HSA-69239 0.344643 0.463 0 0
Generic Transcription Pathway R-HSA-212436 0.347237 0.459 0 0
PERK regulates gene expression R-HSA-381042 0.350087 0.456 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 0.352042 0.453 0 0
DNA Replication Pre-Initiation R-HSA-69002 0.352042 0.453 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 0.356253 0.448 0 0
RET signaling R-HSA-8853659 0.356730 0.448 0 0
HS-GAG biosynthesis R-HSA-2022928 0.356730 0.448 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 0.356730 0.448 0 0
Calmodulin induced events R-HSA-111933 0.356730 0.448 0 0
CaM pathway R-HSA-111997 0.356730 0.448 0 0
Triglyceride catabolism R-HSA-163560 0.356730 0.448 0 0
G1/S-Specific Transcription R-HSA-69205 0.356730 0.448 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 0.363088 0.440 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 0.363088 0.440 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 0.363305 0.440 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 0.363305 0.440 0 0
Ovarian tumor domain proteases R-HSA-5689896 0.363305 0.440 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 0.369814 0.432 0 0
Mitotic Prometaphase R-HSA-68877 0.370145 0.432 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 0.376256 0.425 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 0.377704 0.423 0 0
Interferon alpha/beta signaling R-HSA-909733 0.381337 0.419 0 0
Diseases of Immune System R-HSA-5260271 0.382633 0.417 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 0.382633 0.417 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 0.382633 0.417 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 0.382633 0.417 0 0
Gene expression (Transcription) R-HSA-74160 0.385933 0.413 0 0
Mitochondrial biogenesis R-HSA-1592230 0.388576 0.411 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 0.388945 0.410 0 0
FLT3 Signaling R-HSA-9607240 0.388945 0.410 0 0
Co-inhibition by PD-1 R-HSA-389948 0.389501 0.409 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 0.395007 0.403 0 0
MAP2K and MAPK activation R-HSA-5674135 0.395193 0.403 0 0
Signaling by RAF1 mutants R-HSA-9656223 0.395193 0.403 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 0.395193 0.403 0 0
Viral Infection Pathways R-HSA-9824446 0.395882 0.402 0 0
M Phase R-HSA-68886 0.396729 0.402 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 0.401377 0.396 0 0
Ca-dependent events R-HSA-111996 0.401377 0.396 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 0.402941 0.395 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 0.402941 0.395 0 0
Response of Mtb to phagocytosis R-HSA-9637690 0.407499 0.390 0 0
Netrin-1 signaling R-HSA-373752 0.413558 0.383 0 0
EPHB-mediated forward signaling R-HSA-3928662 0.413558 0.383 1 1
Surfactant metabolism R-HSA-5683826 0.413558 0.383 0 0
Cyclin D associated events in G1 R-HSA-69231 0.413558 0.383 0 0
G1 Phase R-HSA-69236 0.413558 0.383 0 0
Formation of the cornified envelope R-HSA-6809371 0.413611 0.383 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 0.419556 0.377 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 0.419556 0.377 0 0
DAG and IP3 signaling R-HSA-1489509 0.419556 0.377 0 0
Muscle contraction R-HSA-397014 0.425039 0.372 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 0.425493 0.371 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 0.425493 0.371 0 0
Signaling downstream of RAS mutants R-HSA-9649948 0.425493 0.371 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 0.425493 0.371 0 0
Signaling by RAS mutants R-HSA-6802949 0.425493 0.371 0 0
Regulation of pyruvate metabolism R-HSA-9861718 0.425493 0.371 0 0
Signaling by TGFBR3 R-HSA-9839373 0.425493 0.371 0 0
Platelet degranulation R-HSA-114608 0.427689 0.369 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 0.431369 0.365 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 0.431369 0.365 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 0.431369 0.365 0 0
Adipogenesis R-HSA-9843745 0.445036 0.352 0 0
Cardiac conduction R-HSA-5576891 0.445036 0.352 0 0
Azathioprine ADME R-HSA-9748787 0.448643 0.348 0 0
Neddylation R-HSA-8951664 0.449230 0.348 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 0.451894 0.345 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 0.459867 0.337 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 0.459867 0.337 0 0
Neurexins and neuroligins R-HSA-6794361 0.459867 0.337 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 0.459867 0.337 0 0
Smooth Muscle Contraction R-HSA-445355 0.465394 0.332 0 0
Integration of energy metabolism R-HSA-163685 0.465465 0.332 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 0.465465 0.332 0 0
SARS-CoV-2-host interactions R-HSA-9705683 0.467764 0.330 0 0
Translation initiation complex formation R-HSA-72649 0.470865 0.327 0 0
Ribosome-associated quality control R-HSA-9948299 0.472176 0.326 0 0
Signaling by Hedgehog R-HSA-5358351 0.472176 0.326 0 0
Cell Cycle R-HSA-1640170 0.472513 0.326 0 0
PTEN Regulation R-HSA-6807070 0.475513 0.323 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 0.476280 0.322 0 0
G alpha (z) signalling events R-HSA-418597 0.476280 0.322 0 0
Signaling by NOTCH3 R-HSA-9012852 0.476280 0.322 0 0
rRNA processing R-HSA-72312 0.478231 0.320 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 0.481640 0.317 0 0
Signaling by EGFR R-HSA-177929 0.481640 0.317 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 0.481640 0.317 0 0
Macroautophagy R-HSA-1632852 0.482148 0.317 0 0
Extracellular matrix organization R-HSA-1474244 0.485444 0.314 0 0
Dectin-2 family R-HSA-5621480 0.486945 0.313 0 0
Synthesis of PA R-HSA-1483166 0.486945 0.313 0 0
Cell surface interactions at the vascular wall R-HSA-202733 0.491182 0.309 0 0
Clathrin-mediated endocytosis R-HSA-8856828 0.492005 0.308 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 0.492197 0.308 0 0
FCERI mediated NF-kB activation R-HSA-2871837 0.495264 0.305 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 0.497395 0.303 0 0
Triglyceride metabolism R-HSA-8979227 0.497395 0.303 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 0.497395 0.303 0 0
PLC beta mediated events R-HSA-112043 0.507633 0.294 0 0
Signaling by PDGF R-HSA-186797 0.512674 0.290 0 0
NCAM signaling for neurite out-growth R-HSA-375165 0.512674 0.290 0 0
tRNA processing in the nucleus R-HSA-6784531 0.512674 0.290 0 0
Mitochondrial protein import R-HSA-1268020 0.512674 0.290 0 0
MITF-M-dependent gene expression R-HSA-9856651 0.514541 0.289 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 0.517663 0.286 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 0.517663 0.286 0 0
Complex I biogenesis R-HSA-6799198 0.517663 0.286 0 0
Semaphorin interactions R-HSA-373755 0.517663 0.286 1 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 0.517663 0.286 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 0.517663 0.286 0 0
Signaling by PTK6 R-HSA-8848021 0.517663 0.286 0 0
CD22 mediated BCR regulation R-HSA-5690714 0.522602 0.282 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 0.522602 0.282 0 0
DNA Replication R-HSA-69306 0.523998 0.281 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 0.527122 0.278 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 0.527491 0.278 0 0
AURKA Activation by TPX2 R-HSA-8854518 0.532330 0.274 0 0
Autophagy R-HSA-9612973 0.533330 0.273 0 0
G-protein mediated events R-HSA-112040 0.537119 0.270 0 0
Metabolism of steroid hormones R-HSA-196071 0.537119 0.270 0 0
DNA Double Strand Break Response R-HSA-5693606 0.537119 0.270 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 0.541860 0.266 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 0.541860 0.266 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 0.551197 0.259 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 0.555795 0.255 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 0.555795 0.255 0 0
Retinoid metabolism and transport R-HSA-975634 0.555795 0.255 0 0
ECM proteoglycans R-HSA-3000178 0.555795 0.255 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 0.560345 0.252 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 0.564850 0.248 0 0
Centrosome maturation R-HSA-380287 0.573721 0.241 0 0
Protein ubiquitination R-HSA-8852135 0.573721 0.241 0 0
Iron uptake and transport R-HSA-917937 0.573721 0.241 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 0.578089 0.238 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 0.583833 0.234 0 0
RNA Polymerase I Transcription R-HSA-73864 0.586693 0.232 0 0
Cholesterol biosynthesis R-HSA-191273 0.586693 0.232 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 0.595121 0.225 0 0
Signaling by FGFR2 R-HSA-5654738 0.595121 0.225 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 0.595121 0.225 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 0.599272 0.222 0 0
Amyloid fiber formation R-HSA-977225 0.599272 0.222 0 0
Cellular Senescence R-HSA-2559583 0.606178 0.217 0 0
Bacterial Infection Pathways R-HSA-9824439 0.609584 0.215 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 0.611470 0.214 0 0
Oncogenic MAPK signaling R-HSA-6802957 0.615453 0.211 0 0
Protein-protein interactions at synapses R-HSA-6794362 0.615453 0.211 0 0
Diseases of glycosylation R-HSA-3781865 0.617007 0.210 0 0
Post NMDA receptor activation events R-HSA-438064 0.627162 0.203 0 0
Pyruvate metabolism R-HSA-70268 0.627162 0.203 0 0
Ion channel transport R-HSA-983712 0.630223 0.201 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 0.630986 0.200 0 0
Diseases of programmed cell death R-HSA-9645723 0.630986 0.200 0 0
Signaling by WNT R-HSA-195721 0.634713 0.197 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 0.637982 0.195 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 0.638516 0.195 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 0.642224 0.192 0 0
Mitochondrial protein degradation R-HSA-9837999 0.656681 0.183 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 0.658051 0.182 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 0.660204 0.180 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 0.667142 0.176 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 0.667142 0.176 0 0
COPI-mediated anterograde transport R-HSA-6807878 0.667142 0.176 0 0
Signaling by FGFR R-HSA-190236 0.673939 0.171 0 0
Keratinization R-HSA-6805567 0.674878 0.171 0 0
Organelle biogenesis and maintenance R-HSA-1852241 0.679098 0.168 0 0
Glycolysis R-HSA-70171 0.680598 0.167 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 0.683876 0.165 0 0
Epigenetic regulation of gene expression R-HSA-212165 0.684834 0.164 0 0
Membrane Trafficking R-HSA-199991 0.685623 0.164 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 0.687122 0.163 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 0.691031 0.161 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 0.693513 0.159 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 0.693513 0.159 0 0
Platelet homeostasis R-HSA-418346 0.702857 0.153 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 0.708929 0.149 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 0.708929 0.149 0 0
Antimicrobial peptides R-HSA-6803157 0.717806 0.144 0 0
Inositol phosphate metabolism R-HSA-1483249 0.720705 0.142 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 0.723575 0.141 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 0.726415 0.139 0 0
Cap-dependent Translation Initiation R-HSA-72737 0.737487 0.132 0 0
Eukaryotic Translation Initiation R-HSA-72613 0.737487 0.132 0 0
Glucose metabolism R-HSA-70326 0.740185 0.131 0 0
Homology Directed Repair R-HSA-5693538 0.742855 0.129 0 0
Post-translational protein modification R-HSA-597592 0.749644 0.125 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 0.750704 0.125 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 0.755803 0.122 0 0
MHC class II antigen presentation R-HSA-2132295 0.755803 0.122 0 0
Disorders of transmembrane transporters R-HSA-5619115 0.760337 0.119 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 0.763259 0.117 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 0.763259 0.117 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 0.763259 0.117 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 0.765693 0.116 0 0
Sensory perception of taste R-HSA-9717189 0.779787 0.108 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 0.782052 0.107 0 0
Degradation of the extracellular matrix R-HSA-1474228 0.782052 0.107 0 0
O-linked glycosylation R-HSA-5173105 0.795167 0.100 0 0
Transport of small molecules R-HSA-382551 0.811539 0.091 0 0
Visual phototransduction R-HSA-2187338 0.817207 0.088 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 0.826429 0.083 0 0
Protein localization R-HSA-9609507 0.828218 0.082 0 0
DNA Double-Strand Break Repair R-HSA-5693532 0.828218 0.082 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 0.829988 0.081 0 0
PPARA activates gene expression R-HSA-1989781 0.831740 0.080 0 0
Asparagine N-linked glycosylation R-HSA-446203 0.834663 0.078 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 0.835189 0.078 0 0
Cellular response to starvation R-HSA-9711097 0.836888 0.077 0 0
Diseases of metabolism R-HSA-5668914 0.840229 0.076 0 0
Regulation of TP53 Activity R-HSA-5633007 0.840233 0.076 0 0
Translation R-HSA-72766 0.842410 0.074 0 0
Vesicle-mediated transport R-HSA-5653656 0.856878 0.067 0 0
tRNA processing R-HSA-72306 0.857448 0.067 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 0.861814 0.065 0 0
Leishmania parasite growth and survival R-HSA-9664433 0.861814 0.065 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 0.864651 0.063 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 0.868513 0.061 0 0
Metabolism of steroids R-HSA-8957322 0.869524 0.061 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 0.877498 0.057 0 0
Cilium Assembly R-HSA-5617833 0.884160 0.053 0 0
Glycosaminoglycan metabolism R-HSA-1630316 0.887712 0.052 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 0.898790 0.046 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 0.908781 0.042 0 0
Drug ADME R-HSA-9748784 0.914298 0.039 0 0
Metabolism of proteins R-HSA-392499 0.922206 0.035 0 0
Chromatin modifying enzymes R-HSA-3247509 0.927442 0.033 0 0
SLC-mediated transmembrane transport R-HSA-425407 0.929613 0.032 0 0
ESR-mediated signaling R-HSA-8939211 0.929673 0.032 0 0
G alpha (i) signalling events R-HSA-418594 0.935375 0.029 0 0
Chromatin organization R-HSA-4839726 0.937937 0.028 0 0
Developmental Cell Lineages R-HSA-9734767 0.946365 0.024 0 0
G alpha (q) signalling events R-HSA-416476 0.946922 0.024 0 0
Metabolism of amino acids and derivatives R-HSA-71291 0.961209 0.017 0 0
Phospholipid metabolism R-HSA-1483257 0.961598 0.017 0 0
Neuronal System R-HSA-112316 0.961953 0.017 0 0
GPCR downstream signalling R-HSA-388396 0.964909 0.016 0 0
Transmission across Chemical Synapses R-HSA-112315 0.971348 0.013 0 0
DNA Repair R-HSA-73894 0.980559 0.009 0 0
Signaling by GPCR R-HSA-372790 0.981134 0.008 0 0
Signaling by Nuclear Receptors R-HSA-9006931 0.981161 0.008 0 0
Metabolism of vitamins and cofactors R-HSA-196854 0.981358 0.008 0 0
Fatty acid metabolism R-HSA-8978868 0.988261 0.005 0 0
Metabolism of lipids R-HSA-556833 0.998603 0.001 0 0
Sensory Perception R-HSA-9709957 0.999170 0.000 0 0
Metabolism R-HSA-1430728 0.999565 0.000 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.000000 0.000 1 1
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
HSF1 activation R-HSA-3371511 1.110223e-16 15.955 0 0
Attenuation phase R-HSA-3371568 1.110223e-16 15.955 0 0
Cellular response to heat stress R-HSA-3371556 1.110223e-16 15.955 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.110223e-16 15.955 0 0
HSF1-dependent transactivation R-HSA-3371571 1.110223e-16 15.955 0 0
Cellular responses to stimuli R-HSA-8953897 3.903544e-13 12.409 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.000533e-12 12.000 0 0
Cellular responses to stress R-HSA-2262752 5.759948e-12 11.240 0 0
SARS-CoV-1 Infection R-HSA-9678108 9.478129e-11 10.023 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 3.567785e-10 9.448 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 3.703524e-10 9.431 0 0
Eukaryotic Translation Elongation R-HSA-156842 8.609020e-10 9.065 0 0
Translation initiation complex formation R-HSA-72649 2.147081e-09 8.668 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 3.045112e-09 8.516 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 2.981486e-09 8.526 0 0
Axon guidance R-HSA-422475 3.823139e-09 8.418 1 0
SARS-CoV-2-host interactions R-HSA-9705683 6.974319e-09 8.156 0 0
Nervous system development R-HSA-9675108 1.724927e-08 7.763 1 0
SARS-CoV Infections R-HSA-9679506 2.048859e-08 7.688 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 3.417090e-08 7.466 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 7.220595e-08 7.141 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 7.220595e-08 7.141 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 8.434276e-08 7.074 0 0
SARS-CoV-2 Infection R-HSA-9694516 8.155204e-08 7.089 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.427844e-07 6.845 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.427844e-07 6.845 0 0
Peptide chain elongation R-HSA-156902 2.659445e-07 6.575 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 3.742129e-07 6.427 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 3.742129e-07 6.427 0 0
EPH-Ephrin signaling R-HSA-2682334 4.493038e-07 6.347 1 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 7.668352e-07 6.115 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.542477e-06 5.812 0 0
Viral Infection Pathways R-HSA-9824446 1.618331e-06 5.791 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 2.348894e-06 5.629 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 2.698278e-06 5.569 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 2.820150e-06 5.550 0 0
Regulation of CDH1 Function R-HSA-9764561 3.430758e-06 5.465 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 4.060853e-06 5.391 0 0
Chaperone Mediated Autophagy R-HSA-9613829 4.525906e-06 5.344 0 0
Activation of BH3-only proteins R-HSA-114452 4.889865e-06 5.311 0 0
EPHB-mediated forward signaling R-HSA-3928662 5.650422e-06 5.248 1 1
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 5.834569e-06 5.234 0 0
Ribosome-associated quality control R-HSA-9948299 6.001293e-06 5.222 0 0
Apoptosis R-HSA-109581 6.162884e-06 5.210 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 6.455277e-06 5.190 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 9.445968e-06 5.025 0 0
Metabolism of RNA R-HSA-8953854 1.360041e-05 4.866 0 0
Cell-Cell communication R-HSA-1500931 1.345784e-05 4.871 0 0
Signaling by ROBO receptors R-HSA-376176 1.496243e-05 4.825 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.651140e-05 4.782 0 0
Influenza Infection R-HSA-168255 1.761160e-05 4.754 0 0
Programmed Cell Death R-HSA-5357801 1.745134e-05 4.758 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.763029e-05 4.754 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.879714e-05 4.726 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.879714e-05 4.726 0 0
Formation of a pool of free 40S subunits R-HSA-72689 2.693607e-05 4.570 0 0
Eukaryotic Translation Termination R-HSA-72764 2.693607e-05 4.570 0 0
Translation R-HSA-72766 2.594858e-05 4.586 0 0
Interleukin-12 signaling R-HSA-9020591 2.571221e-05 4.590 0 0
Cell junction organization R-HSA-446728 3.442179e-05 4.463 0 0
Selenocysteine synthesis R-HSA-2408557 4.255743e-05 4.371 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 4.451608e-05 4.351 0 0
Viral mRNA Translation R-HSA-192823 4.924435e-05 4.308 0 0
Signaling by Hippo R-HSA-2028269 5.506188e-05 4.259 0 0
Infectious disease R-HSA-5663205 5.552051e-05 4.256 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 6.180748e-05 4.209 0 0
Ephrin signaling R-HSA-3928664 6.777521e-05 4.169 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 6.999605e-05 4.155 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 7.093320e-05 4.149 0 0
Interleukin-12 family signaling R-HSA-447115 7.107015e-05 4.148 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 7.910358e-05 4.102 0 0
Cytokine Signaling in Immune system R-HSA-1280215 7.649242e-05 4.116 0 0
Regulation of signaling by CBL R-HSA-912631 8.263890e-05 4.083 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 8.937144e-05 4.049 0 0
Folding of actin by CCT/TriC R-HSA-390450 9.932173e-05 4.003 0 0
Signal Transduction R-HSA-162582 9.772499e-05 4.010 1 0
Signaling by Interleukins R-HSA-449147 1.201983e-04 3.920 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 1.435336e-04 3.843 0 0
Signaling by NOTCH4 R-HSA-9013694 1.365536e-04 3.865 0 0
Cell-cell junction organization R-HSA-421270 1.373539e-04 3.862 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 1.481815e-04 3.829 0 0
Neutrophil degranulation R-HSA-6798695 1.731593e-04 3.762 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.797543e-04 3.745 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.878552e-04 3.726 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.979883e-04 3.703 0 0
Membrane Trafficking R-HSA-199991 2.069107e-04 3.684 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.165303e-04 3.664 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.165303e-04 3.664 0 0
PKR-mediated signaling R-HSA-9833482 2.192465e-04 3.659 0 0
G2/M Checkpoints R-HSA-69481 2.868907e-04 3.542 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 2.950042e-04 3.530 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 3.198362e-04 3.495 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 3.413048e-04 3.467 0 0
Cellular response to starvation R-HSA-9711097 3.935633e-04 3.405 0 0
Protein methylation R-HSA-8876725 4.167203e-04 3.380 0 0
Cell-extracellular matrix interactions R-HSA-446353 4.167203e-04 3.380 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 4.224192e-04 3.374 0 0
Adherens junctions interactions R-HSA-418990 4.292598e-04 3.367 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 5.274732e-04 3.278 0 0
Developmental Biology R-HSA-1266738 5.361105e-04 3.271 1 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 5.876571e-04 3.231 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 5.787678e-04 3.237 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 5.962478e-04 3.225 0 0
Clathrin-mediated endocytosis R-HSA-8856828 7.509115e-04 3.124 0 0
G2/M DNA damage checkpoint R-HSA-69473 7.773685e-04 3.109 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 8.267312e-04 3.083 0 0
Striated Muscle Contraction R-HSA-390522 8.431888e-04 3.074 0 0
Rap1 signalling R-HSA-392517 9.894747e-04 3.005 0 0
Vesicle-mediated transport R-HSA-5653656 1.059839e-03 2.975 0 0
Signaling by VEGF R-HSA-194138 1.078802e-03 2.967 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.281941e-03 2.892 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.325470e-03 2.878 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.497631e-03 2.825 0 0
Signaling by ERBB2 R-HSA-1227986 1.551731e-03 2.809 0 0
mTORC1-mediated signalling R-HSA-166208 1.733962e-03 2.761 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.792988e-03 2.746 0 0
Selenoamino acid metabolism R-HSA-2408522 1.851479e-03 2.732 0 0
Signaling by RAF1 mutants R-HSA-9656223 2.043485e-03 2.690 0 0
MAP2K and MAPK activation R-HSA-5674135 2.043485e-03 2.690 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 2.432434e-03 2.614 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 2.432434e-03 2.614 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 2.432434e-03 2.614 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 2.432434e-03 2.614 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 2.432434e-03 2.614 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 2.432434e-03 2.614 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 2.432434e-03 2.614 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 2.432434e-03 2.614 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 2.432434e-03 2.614 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 2.432434e-03 2.614 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 2.432434e-03 2.614 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 2.222482e-03 2.653 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.206895e-03 2.656 0 0
rRNA processing R-HSA-72312 2.220225e-03 2.654 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.509840e-03 2.600 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 3.129821e-03 2.504 0 0
Signaling downstream of RAS mutants R-HSA-9649948 3.091826e-03 2.510 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 3.091826e-03 2.510 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 3.091826e-03 2.510 0 0
Signaling by RAS mutants R-HSA-6802949 3.091826e-03 2.510 0 0
MAPK family signaling cascades R-HSA-5683057 2.862664e-03 2.543 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 3.121438e-03 2.506 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 3.246216e-03 2.489 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 3.449777e-03 2.462 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 3.841965e-03 2.415 0 0
RAF/MAP kinase cascade R-HSA-5673001 4.215573e-03 2.375 0 0
Interleukin-37 signaling R-HSA-9008059 4.241193e-03 2.373 0 0
G2/M Transition R-HSA-69275 4.275170e-03 2.369 0 0
Mitotic G2-G2/M phases R-HSA-453274 4.568851e-03 2.340 0 0
EGFR downregulation R-HSA-182971 4.667511e-03 2.331 0 0
Cell Cycle Checkpoints R-HSA-69620 4.818125e-03 2.317 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 5.039487e-03 2.298 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 5.058315e-03 2.296 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 5.345807e-03 2.272 0 0
MTF1 activates gene expression R-HSA-5660489 5.345807e-03 2.272 0 0
Negative regulation of FLT3 R-HSA-9706369 5.801599e-03 2.236 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 6.117052e-03 2.213 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 6.659677e-03 2.177 0 0
Oncogenic MAPK signaling R-HSA-6802957 7.040861e-03 2.152 0 0
Chaperonin-mediated protein folding R-HSA-390466 8.153937e-03 2.089 0 0
FLT3 signaling in disease R-HSA-9682385 7.838516e-03 2.106 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.214630e-03 2.085 0 0
Platelet activation, signaling and aggregation R-HSA-76002 7.361067e-03 2.133 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 7.105093e-03 2.148 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 8.476130e-03 2.072 0 0
Selective autophagy R-HSA-9663891 8.551567e-03 2.068 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 8.656499e-03 2.063 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 9.283472e-03 2.032 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 9.283472e-03 2.032 0 0
VEGF ligand-receptor interactions R-HSA-194313 9.283472e-03 2.032 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 9.283472e-03 2.032 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 9.531912e-03 2.021 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 9.531912e-03 2.021 0 0
Semaphorin interactions R-HSA-373755 9.531912e-03 2.021 1 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.851072e-03 2.007 0 0
Disease R-HSA-1643685 1.023812e-02 1.990 0 0
Aggrephagy R-HSA-9646399 1.058966e-02 1.975 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 1.058966e-02 1.975 0 0
Protein folding R-HSA-391251 1.075051e-02 1.969 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.178907e-02 1.929 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.178907e-02 1.929 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.301694e-02 1.885 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.123421e-02 1.949 0 0
FLT3 Signaling R-HSA-9607240 1.136313e-02 1.945 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.136313e-02 1.945 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 1.136313e-02 1.945 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 1.217204e-02 1.915 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 1.217204e-02 1.915 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.161279e-02 1.935 0 0
MTOR signalling R-HSA-165159 1.301694e-02 1.885 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 1.157726e-02 1.936 0 0
Immune System R-HSA-168256 1.379468e-02 1.860 0 0
Signaling by SCF-KIT R-HSA-1433557 1.389836e-02 1.857 0 0
Autophagy R-HSA-9612973 1.398618e-02 1.854 0 0
Developmental Cell Lineages R-HSA-9734767 1.401212e-02 1.853 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.481679e-02 1.829 0 0
Hedgehog 'off' state R-HSA-5610787 1.566972e-02 1.805 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 1.577270e-02 1.802 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 1.577270e-02 1.802 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 1.577270e-02 1.802 0 0
Drug resistance of FLT3 mutants R-HSA-9702506 1.772643e-02 1.751 0 0
FLT3 mutants bind TKIs R-HSA-9702509 1.772643e-02 1.751 0 0
tamatinib-resistant FLT3 mutants R-HSA-9703009 1.772643e-02 1.751 0 0
lestaurtinib-resistant FLT3 mutants R-HSA-9702596 1.772643e-02 1.751 0 0
gilteritinib-resistant FLT3 mutants R-HSA-9702590 1.772643e-02 1.751 0 0
midostaurin-resistant FLT3 mutants R-HSA-9702600 1.772643e-02 1.751 0 0
KW2449-resistant FLT3 mutants R-HSA-9702569 1.772643e-02 1.751 0 0
semaxanib-resistant FLT3 mutants R-HSA-9702577 1.772643e-02 1.751 0 0
linifanib-resistant FLT3 mutants R-HSA-9702998 1.772643e-02 1.751 0 0
sunitinib-resistant FLT3 mutants R-HSA-9702632 1.772643e-02 1.751 0 0
crenolanib-resistant FLT3 mutants R-HSA-9702581 1.772643e-02 1.751 0 0
ponatinib-resistant FLT3 mutants R-HSA-9702614 1.772643e-02 1.751 0 0
quizartinib-resistant FLT3 mutants R-HSA-9702620 1.772643e-02 1.751 0 0
sorafenib-resistant FLT3 mutants R-HSA-9702624 1.772643e-02 1.751 0 0
tandutinib-resistant FLT3 mutants R-HSA-9702636 1.772643e-02 1.751 0 0
pexidartinib-resistant FLT3 mutants R-HSA-9702605 1.772643e-02 1.751 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 1.694735e-02 1.771 0 0
Formation of annular gap junctions R-HSA-196025 1.694735e-02 1.771 0 0
Gap junction degradation R-HSA-190873 1.993530e-02 1.700 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.598593e-02 1.796 0 0
Centrosome maturation R-HSA-380287 1.755597e-02 1.756 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.993530e-02 1.700 0 0
Adrenoceptors R-HSA-390696 1.694735e-02 1.771 0 0
ARMS-mediated activation R-HSA-170984 1.993530e-02 1.700 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.993530e-02 1.700 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.828829e-02 1.738 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.694735e-02 1.771 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.694735e-02 1.771 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 1.993530e-02 1.700 0 0
Apoptotic execution phase R-HSA-75153 1.676654e-02 1.776 0 0
Gap junction trafficking and regulation R-HSA-157858 1.997969e-02 1.699 0 0
Signaling by EGFR in Cancer R-HSA-1643713 2.033761e-02 1.692 0 0
Azathioprine ADME R-HSA-9748787 2.112920e-02 1.675 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.196385e-02 1.658 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 2.201873e-02 1.657 0 0
Hedgehog ligand biogenesis R-HSA-5358346 2.231848e-02 1.651 0 0
Signaling by Hedgehog R-HSA-5358351 2.268290e-02 1.644 0 0
Cell Cycle R-HSA-1640170 2.286626e-02 1.641 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 2.312589e-02 1.636 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 2.312589e-02 1.636 0 0
Leishmania phagocytosis R-HSA-9664417 2.409524e-02 1.618 0 0
Parasite infection R-HSA-9664407 2.409524e-02 1.618 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 2.409524e-02 1.618 0 0
Late endosomal microautophagy R-HSA-9615710 2.560185e-02 1.592 0 0
PECAM1 interactions R-HSA-210990 2.651104e-02 1.577 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 2.693054e-02 1.570 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 2.750370e-02 1.561 0 0
DAP12 signaling R-HSA-2424491 2.750370e-02 1.561 0 0
Innate Immune System R-HSA-168249 2.767692e-02 1.558 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 2.801345e-02 1.553 0 0
Signaling by EGFR R-HSA-177929 2.887124e-02 1.540 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 2.947886e-02 1.530 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 3.008291e-02 1.522 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 3.008291e-02 1.522 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 3.008291e-02 1.522 0 0
Pyruvate metabolism R-HSA-70268 3.026128e-02 1.519 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 3.513970e-02 1.454 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 3.383387e-02 1.471 0 0
Scavenging by Class F Receptors R-HSA-3000484 3.383387e-02 1.471 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 3.142654e-02 1.503 0 0
mRNA Splicing - Major Pathway R-HSA-72163 3.950688e-02 1.403 0 0
Integrin signaling R-HSA-354192 3.364800e-02 1.473 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 3.384053e-02 1.471 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 3.810648e-02 1.419 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 3.383387e-02 1.471 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 3.810648e-02 1.419 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 4.044308e-02 1.393 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 4.044308e-02 1.393 0 0
ER-Phagosome pathway R-HSA-1236974 3.261958e-02 1.487 0 0
Frs2-mediated activation R-HSA-170968 3.775649e-02 1.423 0 0
Inhibition of PKR R-HSA-169131 3.513970e-02 1.454 0 0
Vpu mediated degradation of CD4 R-HSA-180534 3.584129e-02 1.446 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 3.810648e-02 1.419 0 0
Regulation of Apoptosis R-HSA-169911 4.044308e-02 1.393 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 3.476638e-02 1.459 0 0
Interferon Signaling R-HSA-913531 3.158713e-02 1.500 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 3.645296e-02 1.438 0 0
Maturation of nucleoprotein R-HSA-9683610 3.775649e-02 1.423 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 3.977729e-02 1.400 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 3.376639e-02 1.472 0 0
Interleukin-1 family signaling R-HSA-446652 3.476638e-02 1.459 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 3.385055e-02 1.470 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 3.383387e-02 1.471 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 3.273801e-02 1.485 0 0
Potential therapeutics for SARS R-HSA-9679191 3.295094e-02 1.482 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 3.152706e-02 1.501 0 0
Regulation of KIT signaling R-HSA-1433559 4.184354e-02 1.378 0 0
GPVI-mediated activation cascade R-HSA-114604 4.285055e-02 1.368 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 4.285055e-02 1.368 0 0
Degradation of DVL R-HSA-4641258 4.532828e-02 1.344 0 0
Degradation of AXIN R-HSA-4641257 4.532828e-02 1.344 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 4.608802e-02 1.336 0 0
Spry regulation of FGF signaling R-HSA-1295596 4.608802e-02 1.336 0 0
Leishmania infection R-HSA-9658195 4.631740e-02 1.334 0 0
Parasitic Infection Pathways R-HSA-9824443 4.631740e-02 1.334 0 0
FOXO-mediated transcription R-HSA-9614085 4.914611e-02 1.309 0 0
mRNA Splicing R-HSA-72172 5.025262e-02 1.299 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 5.048310e-02 1.297 0 0
Prolonged ERK activation events R-HSA-169893 5.048310e-02 1.297 0 0
Stabilization of p53 R-HSA-69541 5.049189e-02 1.297 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 5.049189e-02 1.297 0 0
ABC-family proteins mediated transport R-HSA-382556 5.071004e-02 1.295 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 5.075298e-02 1.295 0 0
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway R-HSA-73930 5.224533e-02 1.282 0 0
Manipulation of host energy metabolism R-HSA-9636667 5.224533e-02 1.282 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 5.224533e-02 1.282 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 5.272800e-02 1.278 0 0
Extracellular matrix organization R-HSA-1474244 5.316058e-02 1.274 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 5.317634e-02 1.274 0 0
Hedgehog 'on' state R-HSA-5632684 5.474442e-02 1.262 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 5.502214e-02 1.259 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 5.502214e-02 1.259 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 5.502214e-02 1.259 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 5.502214e-02 1.259 0 0
Response to metal ions R-HSA-5660526 5.502214e-02 1.259 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 5.592822e-02 1.252 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 5.592822e-02 1.252 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 5.592822e-02 1.252 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 8.555524e-02 1.068 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 5.969871e-02 1.224 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 5.969871e-02 1.224 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 5.969871e-02 1.224 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 6.450653e-02 1.190 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 8.493125e-02 1.071 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 8.493125e-02 1.071 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 7.380759e-02 1.132 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 5.874671e-02 1.231 0 0
Ub-specific processing proteases R-HSA-5689880 5.918185e-02 1.228 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 7.066936e-02 1.151 0 0
Degradation of CRY and PER proteins R-HSA-9932298 5.874671e-02 1.231 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 7.700692e-02 1.113 0 0
UCH proteinases R-HSA-5689603 6.544191e-02 1.184 0 0
Negative regulation of MET activity R-HSA-6807004 7.449178e-02 1.128 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 8.493125e-02 1.071 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 6.904874e-02 1.161 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 5.874671e-02 1.231 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 8.493125e-02 1.071 0 0
Regulation of RAS by GAPs R-HSA-5658442 8.696125e-02 1.061 0 0
DAP12 interactions R-HSA-2172127 6.759320e-02 1.170 0 0
Recycling pathway of L1 R-HSA-437239 7.700692e-02 1.113 0 0
Gap junction trafficking R-HSA-190828 6.759320e-02 1.170 0 0
ABC transporter disorders R-HSA-5619084 7.000449e-02 1.155 0 0
Mitotic Anaphase R-HSA-68882 6.395632e-02 1.194 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 8.555524e-02 1.068 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 6.519368e-02 1.186 0 0
Antigen processing-Cross presentation R-HSA-1236975 6.608745e-02 1.180 0 0
ISG15 antiviral mechanism R-HSA-1169408 6.322096e-02 1.199 0 0
Degradation of CDH1 R-HSA-9766229 8.358479e-02 1.078 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 5.890085e-02 1.230 0 0
M Phase R-HSA-68886 6.086592e-02 1.216 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 6.458009e-02 1.190 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 6.759320e-02 1.170 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 7.066936e-02 1.151 0 0
Macroautophagy R-HSA-1632852 6.642994e-02 1.178 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 8.493125e-02 1.071 0 0
The NLRP3 inflammasome R-HSA-844456 6.943952e-02 1.158 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 7.066936e-02 1.151 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 7.380759e-02 1.132 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 7.380759e-02 1.132 0 0
Protein hydroxylation R-HSA-9629569 7.449178e-02 1.128 0 0
Signaling by FGFR2 R-HSA-5654738 7.472632e-02 1.127 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 8.358479e-02 1.078 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 8.358479e-02 1.078 0 0
Muscle contraction R-HSA-397014 5.915443e-02 1.228 0 0
Signaling by PDGFR in disease R-HSA-9671555 8.493125e-02 1.071 0 0
Signaling by MET R-HSA-6806834 7.472632e-02 1.127 0 0
Formation of definitive endoderm R-HSA-9823730 7.449178e-02 1.128 0 0
Maturation of nucleoprotein R-HSA-9694631 6.943952e-02 1.158 0 0
PIP3 activates AKT signaling R-HSA-1257604 5.914273e-02 1.228 0 0
Response of Mtb to phagocytosis R-HSA-9637690 6.458009e-02 1.190 0 0
Gluconeogenesis R-HSA-70263 8.026633e-02 1.095 0 0
Specification of primordial germ cells R-HSA-9827857 5.969871e-02 1.224 0 0
Cellular response to chemical stress R-HSA-9711123 7.655670e-02 1.116 0 0
Translation of Structural Proteins R-HSA-9683701 5.874671e-02 1.231 0 0
Nephrin family interactions R-HSA-373753 7.449178e-02 1.128 0 0
Mitotic Prometaphase R-HSA-68877 8.874366e-02 1.052 0 0
FGFR2 alternative splicing R-HSA-6803529 9.030747e-02 1.044 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 9.030747e-02 1.044 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.039464e-02 1.044 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.039464e-02 1.044 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 9.119330e-02 1.040 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.388388e-02 1.027 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.388388e-02 1.027 0 0
Orc1 removal from chromatin R-HSA-68949 9.388388e-02 1.027 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.388388e-02 1.027 0 0
Post NMDA receptor activation events R-HSA-438064 9.515863e-02 1.022 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 9.578095e-02 1.019 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 9.742788e-02 1.011 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 9.742788e-02 1.011 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.742788e-02 1.011 0 0
Regulation of PTEN stability and activity R-HSA-8948751 9.742788e-02 1.011 0 0
Smooth Muscle Contraction R-HSA-445355 9.742788e-02 1.011 0 0
Signaling by NOTCH R-HSA-157118 9.775086e-02 1.010 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.841136e-02 1.007 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 1.010255e-01 0.996 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 1.013466e-01 0.994 0 0
Deadenylation of mRNA R-HSA-429947 1.013466e-01 0.994 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.013466e-01 0.994 0 0
Neurodegenerative Diseases R-HSA-8863678 1.013466e-01 0.994 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.017701e-01 0.992 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 1.017701e-01 0.992 0 0
Regulation of gap junction activity R-HSA-191650 1.017701e-01 0.992 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.017701e-01 0.992 0 0
NADE modulates death signalling R-HSA-205025 1.017701e-01 0.992 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 1.046757e-01 0.980 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 1.061676e-01 0.974 0 0
Long-term potentiation R-HSA-9620244 1.069994e-01 0.971 0 0
Tight junction interactions R-HSA-420029 1.069994e-01 0.971 0 0
Cell Cycle, Mitotic R-HSA-69278 1.079426e-01 0.967 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 1.083772e-01 0.965 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.083772e-01 0.965 0 0
Separation of Sister Chromatids R-HSA-2467813 1.106110e-01 0.956 0 0
Platelet degranulation R-HSA-114608 1.132955e-01 0.946 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.176984e-01 0.929 0 0
STAT5 Activation R-HSA-9645135 1.487154e-01 0.828 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 1.638140e-01 0.786 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.638140e-01 0.786 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.638140e-01 0.786 0 0
ALKBH3 mediated reversal of alkylation damage R-HSA-112126 1.786457e-01 0.748 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.786457e-01 0.748 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.786457e-01 0.748 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.932153e-01 0.714 0 0
Lipophagy R-HSA-9613354 1.932153e-01 0.714 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 2.075273e-01 0.683 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 2.215862e-01 0.654 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 2.215862e-01 0.654 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 2.215862e-01 0.654 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 2.353966e-01 0.628 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.353966e-01 0.628 0 0
Cristae formation R-HSA-8949613 1.185475e-01 0.926 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.303884e-01 0.885 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 1.673318e-01 0.776 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 1.239563e-01 0.907 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 2.075273e-01 0.683 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.364077e-01 0.865 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 1.932153e-01 0.714 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.610494e-01 0.793 0 0
Deubiquitination R-HSA-5688426 1.231668e-01 0.910 0 0
Binding and entry of HIV virion R-HSA-173107 2.075273e-01 0.683 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 1.424875e-01 0.846 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.244335e-01 0.905 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 1.303884e-01 0.885 0 0
Regulation of PTEN localization R-HSA-8948747 1.638140e-01 0.786 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 1.786457e-01 0.748 0 0
Josephin domain DUBs R-HSA-5689877 2.075273e-01 0.683 0 0
vRNP Assembly R-HSA-192905 2.215862e-01 0.654 0 0
Signaling by APC mutants R-HSA-4839744 2.215862e-01 0.654 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 2.353966e-01 0.628 0 0
Signaling by AMER1 mutants R-HSA-4839748 2.353966e-01 0.628 0 0
Signaling by AXIN mutants R-HSA-4839735 2.353966e-01 0.628 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.185475e-01 0.926 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 1.179249e-01 0.928 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.460535e-01 0.835 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 2.015376e-01 0.696 0 0
ER to Golgi Anterograde Transport R-HSA-199977 1.756758e-01 0.755 0 0
Protein localization R-HSA-9609507 1.937638e-01 0.713 0 0
Regulation of necroptotic cell death R-HSA-5675482 1.548122e-01 0.810 0 0
Mitochondrial protein import R-HSA-1268020 1.316009e-01 0.881 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.786457e-01 0.748 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 1.932153e-01 0.714 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 2.215862e-01 0.654 0 0
Chylomicron assembly R-HSA-8963888 2.215862e-01 0.654 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 1.185475e-01 0.926 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 1.486236e-01 0.828 0 0
Regulation of mitotic cell cycle R-HSA-453276 1.692775e-01 0.771 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 1.692775e-01 0.771 0 0
Switching of origins to a post-replicative state R-HSA-69052 1.780402e-01 0.749 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 1.244335e-01 0.905 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 1.244335e-01 0.905 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 1.303884e-01 0.885 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 1.673318e-01 0.776 0 0
Cilium Assembly R-HSA-5617833 1.741688e-01 0.759 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.564240e-01 0.806 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 1.176984e-01 0.929 0 0
LDL remodeling R-HSA-8964041 1.638140e-01 0.786 0 0
Regulation of signaling by NODAL R-HSA-1433617 1.932153e-01 0.714 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 2.075273e-01 0.683 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 2.353966e-01 0.628 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 1.486236e-01 0.828 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 1.548122e-01 0.810 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 1.736430e-01 0.760 0 0
Signalling to ERKs R-HSA-187687 1.736556e-01 0.760 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 1.928425e-01 0.715 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.864142e-01 0.730 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.548122e-01 0.810 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.864142e-01 0.730 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 1.992992e-01 0.700 0 0
TBC/RABGAPs R-HSA-8854214 2.319069e-01 0.635 0 0
G alpha (12/13) signalling events R-HSA-416482 2.004602e-01 0.698 0 0
Mitophagy R-HSA-5205647 1.673318e-01 0.776 0 0
NF-kB is activated and signals survival R-HSA-209560 2.353966e-01 0.628 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 1.424875e-01 0.846 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 2.096101e-01 0.679 0 0
Death Receptor Signaling R-HSA-73887 1.968408e-01 0.706 0 0
Host Interactions of HIV factors R-HSA-162909 2.351409e-01 0.629 0 0
S Phase R-HSA-69242 1.786444e-01 0.748 0 0
Negative regulation of MAPK pathway R-HSA-5675221 2.188101e-01 0.660 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.590411e-01 0.798 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 2.319069e-01 0.635 0 0
RSV-host interactions R-HSA-9833110 1.559637e-01 0.807 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.932153e-01 0.714 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 1.309948e-01 0.883 0 0
Hemostasis R-HSA-109582 1.970904e-01 0.705 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.272155e-01 0.644 0 0
Maturation of protein E R-HSA-9683683 1.333452e-01 0.875 0 0
Maturation of protein E R-HSA-9694493 1.333452e-01 0.875 0 0
VLDL assembly R-HSA-8866423 1.487154e-01 0.828 0 0
CHL1 interactions R-HSA-447041 1.638140e-01 0.786 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 1.932153e-01 0.714 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 2.215862e-01 0.654 0 0
Cellular response to hypoxia R-HSA-1234174 1.438126e-01 0.842 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 1.270205e-01 0.896 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 1.397008e-01 0.855 0 0
Modulation by Mtb of host immune system R-HSA-9637628 1.786457e-01 0.748 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 1.244335e-01 0.905 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 2.235022e-01 0.651 0 0
Oncogene Induced Senescence R-HSA-2559585 1.736556e-01 0.760 0 0
Pexophagy R-HSA-9664873 2.075273e-01 0.683 0 0
Sensory processing of sound R-HSA-9659379 2.050233e-01 0.688 0 0
L1CAM interactions R-HSA-373760 2.051986e-01 0.688 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 2.075273e-01 0.683 0 0
Suppression of apoptosis R-HSA-9635465 2.215862e-01 0.654 0 0
Inflammasomes R-HSA-622312 1.244335e-01 0.905 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 1.316009e-01 0.881 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.563820e-01 0.806 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 2.313397e-01 0.636 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.364012e-01 0.865 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 1.649447e-01 0.783 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 2.281733e-01 0.642 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.096101e-01 0.679 0 0
RUNX2 regulates bone development R-HSA-8941326 1.800176e-01 0.745 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.649447e-01 0.783 0 0
Signaling by FGFR4 R-HSA-5654743 2.319069e-01 0.635 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 1.736430e-01 0.760 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.611272e-01 0.793 0 0
Signaling by FGFR R-HSA-190236 1.332434e-01 0.875 0 0
Interleukin-2 signaling R-HSA-9020558 2.215862e-01 0.654 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.736430e-01 0.760 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.179769e-01 0.928 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.932153e-01 0.714 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 2.353966e-01 0.628 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.649447e-01 0.783 0 0
Interleukin-23 signaling R-HSA-9020933 1.786457e-01 0.748 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.185475e-01 0.926 0 0
MET promotes cell motility R-HSA-8875878 1.928425e-01 0.715 0 0
PCP/CE pathway R-HSA-4086400 2.004602e-01 0.698 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.906765e-01 0.720 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.649717e-01 0.783 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.416377e-01 0.849 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.356298e-01 0.868 0 0
Signaling by PTK6 R-HSA-8848021 1.356298e-01 0.868 0 0
Translation of Structural Proteins R-HSA-9694635 1.959221e-01 0.708 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.992992e-01 0.700 0 0
Integrin cell surface interactions R-HSA-216083 2.004602e-01 0.698 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.272997e-01 0.895 0 0
Proteasome assembly R-HSA-9907900 2.384742e-01 0.623 0 0
Amine ligand-binding receptors R-HSA-375280 2.384742e-01 0.623 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 2.422930e-01 0.616 0 0
Signaling by FGFR3 R-HSA-5654741 2.450508e-01 0.611 0 0
Somitogenesis R-HSA-9824272 2.450508e-01 0.611 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.489628e-01 0.604 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 2.489628e-01 0.604 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 2.489628e-01 0.604 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.489628e-01 0.604 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.489628e-01 0.604 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.489628e-01 0.604 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.489628e-01 0.604 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 2.489628e-01 0.604 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 2.489628e-01 0.604 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 2.489628e-01 0.604 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 2.489628e-01 0.604 0 0
IRAK1 recruits IKK complex R-HSA-937039 2.489628e-01 0.604 0 0
VLDLR internalisation and degradation R-HSA-8866427 2.489628e-01 0.604 0 0
p75NTR recruits signalling complexes R-HSA-209543 2.489628e-01 0.604 0 0
Signaling by LTK R-HSA-9842663 2.489628e-01 0.604 0 0
OAS antiviral response R-HSA-8983711 2.489628e-01 0.604 0 0
Regulation of TNFR1 signaling R-HSA-5357905 2.516343e-01 0.599 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 2.516343e-01 0.599 0 0
Regulation of pyruvate metabolism R-HSA-9861718 2.516343e-01 0.599 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.581438e-01 0.588 0 0
Downstream TCR signaling R-HSA-202424 2.613301e-01 0.583 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 2.621402e-01 0.581 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 2.622891e-01 0.581 0 0
CD28 dependent Vav1 pathway R-HSA-389359 2.622891e-01 0.581 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 2.622891e-01 0.581 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 2.622891e-01 0.581 0 0
Interleukin-6 signaling R-HSA-1059683 2.622891e-01 0.581 0 0
Co-stimulation by CD28 R-HSA-389356 2.648129e-01 0.577 0 0
Circadian clock R-HSA-9909396 2.738913e-01 0.562 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 2.753798e-01 0.560 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 2.753798e-01 0.560 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 2.753798e-01 0.560 0 0
NRIF signals cell death from the nucleus R-HSA-205043 2.753798e-01 0.560 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 2.753798e-01 0.560 0 0
CRMPs in Sema3A signaling R-HSA-399956 2.753798e-01 0.560 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 2.753798e-01 0.560 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 2.753798e-01 0.560 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 2.753798e-01 0.560 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 2.757316e-01 0.560 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 2.805507e-01 0.552 0 0
Assembly of the pre-replicative complex R-HSA-68867 2.805507e-01 0.552 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.882390e-01 0.540 0 0
G beta:gamma signalling through BTK R-HSA-8964315 2.882390e-01 0.540 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 2.882390e-01 0.540 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 2.882390e-01 0.540 0 0
Translesion synthesis by REV1 R-HSA-110312 2.882390e-01 0.540 0 0
DNA Damage Reversal R-HSA-73942 2.882390e-01 0.540 0 0
Erythropoietin activates RAS R-HSA-9027284 2.882390e-01 0.540 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.882390e-01 0.540 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.882390e-01 0.540 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 2.882390e-01 0.540 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 2.882390e-01 0.540 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 2.882390e-01 0.540 0 0
p75NTR signals via NF-kB R-HSA-193639 2.882390e-01 0.540 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 2.902111e-01 0.537 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 2.911568e-01 0.536 0 0
mRNA 3'-end processing R-HSA-72187 2.911568e-01 0.536 0 0
Neurexins and neuroligins R-HSA-6794361 2.911568e-01 0.536 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 2.977284e-01 0.526 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.998954e-01 0.523 0 0
COPI-mediated anterograde transport R-HSA-6807878 2.998954e-01 0.523 0 0
Translesion synthesis by POLI R-HSA-5656121 3.008707e-01 0.522 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 3.008707e-01 0.522 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 3.008707e-01 0.522 0 0
Regulation of BACH1 activity R-HSA-9708530 3.008707e-01 0.522 0 0
Metabolism of proteins R-HSA-392499 3.034027e-01 0.518 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 3.047443e-01 0.516 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 3.047443e-01 0.516 0 0
PTEN Regulation R-HSA-6807070 3.056176e-01 0.515 0 0
ESR-mediated signaling R-HSA-8939211 3.130551e-01 0.504 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 3.132791e-01 0.504 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 3.132791e-01 0.504 0 0
Translesion synthesis by POLK R-HSA-5655862 3.132791e-01 0.504 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 3.132791e-01 0.504 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 3.132791e-01 0.504 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 3.132791e-01 0.504 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 3.132791e-01 0.504 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 3.132791e-01 0.504 0 0
TNF signaling R-HSA-75893 3.173800e-01 0.498 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 3.173800e-01 0.498 0 0
NRAGE signals death through JNK R-HSA-193648 3.173800e-01 0.498 0 0
Signaling by FGFR1 R-HSA-5654736 3.173800e-01 0.498 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 3.173800e-01 0.498 0 0
Glycolysis R-HSA-70171 3.193082e-01 0.496 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 3.239039e-01 0.490 0 0
Interleukin-1 signaling R-HSA-9020702 3.241659e-01 0.489 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 3.254679e-01 0.487 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 3.254679e-01 0.487 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 3.254679e-01 0.487 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 3.254679e-01 0.487 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 3.254679e-01 0.487 0 0
Glycogen storage diseases R-HSA-3229121 3.254679e-01 0.487 0 0
Regulation of endogenous retroelements R-HSA-9842860 3.290236e-01 0.483 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 3.369023e-01 0.472 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 3.374412e-01 0.472 0 0
Platelet sensitization by LDL R-HSA-432142 3.374412e-01 0.472 0 0
Mismatch Repair R-HSA-5358508 3.374412e-01 0.472 0 0
Synaptic adhesion-like molecules R-HSA-8849932 3.374412e-01 0.472 0 0
Transport of connexons to the plasma membrane R-HSA-190872 3.374412e-01 0.472 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 3.374412e-01 0.472 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 3.374412e-01 0.472 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 3.374412e-01 0.472 0 0
Response of endothelial cells to shear stress R-HSA-9860931 3.387367e-01 0.470 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 3.433740e-01 0.464 0 0
Metabolism of polyamines R-HSA-351202 3.433740e-01 0.464 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 3.457598e-01 0.461 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 3.484412e-01 0.458 0 0
Translesion Synthesis by POLH R-HSA-110320 3.492026e-01 0.457 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 3.492026e-01 0.457 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 3.492026e-01 0.457 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 3.492026e-01 0.457 0 0
Gastrulation R-HSA-9758941 3.497871e-01 0.456 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 3.498254e-01 0.456 0 0
MAP kinase activation R-HSA-450294 3.498254e-01 0.456 0 0
Formation of paraxial mesoderm R-HSA-9793380 3.498254e-01 0.456 0 0
Co-inhibition by PD-1 R-HSA-389948 3.547958e-01 0.450 0 0
Signaling by PDGF R-HSA-186797 3.562553e-01 0.448 0 0
Synthesis of DNA R-HSA-69239 3.581316e-01 0.446 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 3.581316e-01 0.446 0 0
Signaling by ALK in cancer R-HSA-9700206 3.581316e-01 0.446 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 3.607560e-01 0.443 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 3.607560e-01 0.443 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 3.607560e-01 0.443 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 3.607560e-01 0.443 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 3.607560e-01 0.443 1 1
Co-inhibition by CTLA4 R-HSA-389513 3.607560e-01 0.443 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 3.607560e-01 0.443 0 0
Signaling by NODAL R-HSA-1181150 3.607560e-01 0.443 0 0
Glycogen synthesis R-HSA-3322077 3.607560e-01 0.443 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 3.607560e-01 0.443 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 3.618274e-01 0.441 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 3.626624e-01 0.440 0 0
Stimuli-sensing channels R-HSA-2672351 3.629697e-01 0.440 0 0
DNA Replication Pre-Initiation R-HSA-69002 3.678022e-01 0.434 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 3.721050e-01 0.429 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 3.721050e-01 0.429 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 3.721050e-01 0.429 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 3.721050e-01 0.429 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 3.721050e-01 0.429 0 0
Early Phase of HIV Life Cycle R-HSA-162594 3.721050e-01 0.429 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 3.721050e-01 0.429 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 3.721050e-01 0.429 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 3.726283e-01 0.429 0 0
MyD88-independent TLR4 cascade R-HSA-166166 3.726283e-01 0.429 0 0
TCR signaling R-HSA-202403 3.726283e-01 0.429 0 0
FCERI mediated MAPK activation R-HSA-2871796 3.822592e-01 0.418 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 3.832532e-01 0.417 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 3.832532e-01 0.417 0 0
Attachment and Entry R-HSA-9694614 3.832532e-01 0.417 0 0
Assembly Of The HIV Virion R-HSA-175474 3.832532e-01 0.417 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 3.832532e-01 0.417 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 3.832532e-01 0.417 0 0
Ribavirin ADME R-HSA-9755088 3.832532e-01 0.417 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 3.942041e-01 0.404 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 3.942041e-01 0.404 0 0
Signaling by KIT in disease R-HSA-9669938 3.942041e-01 0.404 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 3.942041e-01 0.404 0 0
Regulated Necrosis R-HSA-5218859 3.943152e-01 0.404 0 0
Interferon alpha/beta signaling R-HSA-909733 4.061824e-01 0.391 0 0
COPII-mediated vesicle transport R-HSA-204005 4.067780e-01 0.391 0 0
Interleukin-17 signaling R-HSA-448424 4.067780e-01 0.391 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 4.129632e-01 0.384 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 4.129632e-01 0.384 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 4.155280e-01 0.381 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 4.155280e-01 0.381 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 4.155280e-01 0.381 0 0
Plasma lipoprotein assembly R-HSA-8963898 4.155280e-01 0.381 0 0
Mitochondrial RNA degradation R-HSA-9836573 4.155280e-01 0.381 0 0
Interleukin-6 family signaling R-HSA-6783589 4.155280e-01 0.381 0 0
Rab regulation of trafficking R-HSA-9007101 4.156778e-01 0.381 0 0
Glucose metabolism R-HSA-70326 4.156778e-01 0.381 0 0
Mitochondrial biogenesis R-HSA-1592230 4.156778e-01 0.381 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 4.251244e-01 0.371 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 4.251244e-01 0.371 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 4.259078e-01 0.371 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 4.259078e-01 0.371 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 4.259078e-01 0.371 0 0
TGFBR3 expression R-HSA-9839394 4.259078e-01 0.371 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 4.259078e-01 0.371 0 0
Sema4D in semaphorin signaling R-HSA-400685 4.259078e-01 0.371 1 0
Laminin interactions R-HSA-3000157 4.259078e-01 0.371 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 4.259078e-01 0.371 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 4.345181e-01 0.362 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 4.345181e-01 0.362 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 4.352645e-01 0.361 0 0
Metalloprotease DUBs R-HSA-5689901 4.361038e-01 0.360 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 4.361038e-01 0.360 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 4.361038e-01 0.360 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 4.361038e-01 0.360 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 4.361038e-01 0.360 0 0
Suppression of phagosomal maturation R-HSA-9637687 4.361038e-01 0.360 0 0
Protein ubiquitination R-HSA-8852135 4.373756e-01 0.359 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 4.391938e-01 0.357 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 4.391938e-01 0.357 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 4.417487e-01 0.355 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 4.438549e-01 0.353 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 4.461194e-01 0.351 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 4.461194e-01 0.351 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 4.461194e-01 0.351 0 0
Insulin processing R-HSA-264876 4.461194e-01 0.351 0 0
Formation of the cornified envelope R-HSA-6809371 4.485009e-01 0.348 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 4.493428e-01 0.347 0 0
HIV Infection R-HSA-162906 4.527973e-01 0.344 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 4.547349e-01 0.342 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 4.574235e-01 0.340 0 0
G1/S Transition R-HSA-69206 4.577457e-01 0.339 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 4.612283e-01 0.336 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 4.656219e-01 0.332 0 0
Termination of translesion DNA synthesis R-HSA-5656169 4.656219e-01 0.332 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 4.656219e-01 0.332 0 0
Signaling by Erythropoietin R-HSA-9006335 4.656219e-01 0.332 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 4.656219e-01 0.332 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 4.714886e-01 0.327 0 0
Metabolism of amino acids and derivatives R-HSA-71291 4.727608e-01 0.325 0 0
Amyloid fiber formation R-HSA-977225 4.729322e-01 0.325 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 4.751149e-01 0.323 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 4.751149e-01 0.323 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 4.751149e-01 0.323 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 4.787267e-01 0.320 0 0
Downstream signal transduction R-HSA-186763 4.844399e-01 0.315 0 0
Budding and maturation of HIV virion R-HSA-162588 4.844399e-01 0.315 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 4.844399e-01 0.315 0 0
Cargo concentration in the ER R-HSA-5694530 4.844399e-01 0.315 0 0
Reproduction R-HSA-1474165 4.850729e-01 0.314 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 4.901982e-01 0.310 0 0
Signaling by WNT in cancer R-HSA-4791275 4.935998e-01 0.307 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 4.935998e-01 0.307 0 0
HS-GAG degradation R-HSA-2024096 4.935998e-01 0.307 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 4.940361e-01 0.306 0 0
Protein-protein interactions at synapses R-HSA-6794362 4.958744e-01 0.305 0 0
G-protein beta:gamma signalling R-HSA-397795 5.025975e-01 0.299 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 5.025975e-01 0.299 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 5.025975e-01 0.299 0 0
Signaling by WNT R-HSA-195721 5.040495e-01 0.298 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 5.071058e-01 0.295 0 0
XBP1(S) activates chaperone genes R-HSA-381038 5.071058e-01 0.295 0 0
Acyl chain remodelling of PC R-HSA-1482788 5.114359e-01 0.291 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 5.160989e-01 0.287 0 0
Diseases of programmed cell death R-HSA-9645723 5.181735e-01 0.286 0 0
Toll-like Receptor Cascades R-HSA-168898 5.184597e-01 0.285 0 0
RAF activation R-HSA-5673000 5.201178e-01 0.284 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 5.201178e-01 0.284 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 5.201178e-01 0.284 0 0
Dual Incision in GG-NER R-HSA-5696400 5.201178e-01 0.284 0 0
Nuclear import of Rev protein R-HSA-180746 5.201178e-01 0.284 0 0
eNOS activation R-HSA-203615 5.201178e-01 0.284 0 0
NOD1/2 Signaling Pathway R-HSA-168638 5.201178e-01 0.284 0 0
Gap junction assembly R-HSA-190861 5.201178e-01 0.284 0 0
Calnexin/calreticulin cycle R-HSA-901042 5.201178e-01 0.284 0 0
Signaling by NOTCH2 R-HSA-1980145 5.201178e-01 0.284 0 0
Hyaluronan metabolism R-HSA-2142845 5.201178e-01 0.284 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 5.221710e-01 0.282 0 0
Acyl chain remodelling of PE R-HSA-1482839 5.286459e-01 0.277 0 0
HS-GAG biosynthesis R-HSA-2022928 5.370230e-01 0.270 0 0
Regulation of TP53 Degradation R-HSA-6804757 5.370230e-01 0.270 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 5.370230e-01 0.270 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 5.370230e-01 0.270 0 0
IRE1alpha activates chaperones R-HSA-381070 5.398089e-01 0.268 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 5.451121e-01 0.264 0 0
Ovarian tumor domain proteases R-HSA-5689896 5.452517e-01 0.263 0 0
FCGR activation R-HSA-2029481 5.503728e-01 0.259 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 5.533346e-01 0.257 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 5.533346e-01 0.257 0 0
FCERI mediated NF-kB activation R-HSA-2871837 5.544738e-01 0.256 0 0
Mitochondrial protein degradation R-HSA-9837999 5.555906e-01 0.255 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 5.612744e-01 0.251 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 5.612744e-01 0.251 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 5.612744e-01 0.251 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 5.612744e-01 0.251 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 5.612744e-01 0.251 0 0
Pentose phosphate pathway R-HSA-71336 5.612744e-01 0.251 0 0
RAS processing R-HSA-9648002 5.612744e-01 0.251 0 0
Plasma lipoprotein clearance R-HSA-8964043 5.612744e-01 0.251 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 5.627537e-01 0.250 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 5.690735e-01 0.245 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 5.690735e-01 0.245 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 5.690735e-01 0.245 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 5.690735e-01 0.245 0 0
Diseases of Immune System R-HSA-5260271 5.690735e-01 0.245 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 5.690735e-01 0.245 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 5.690735e-01 0.245 0 0
Glycogen metabolism R-HSA-8982491 5.690735e-01 0.245 0 0
Interleukin-2 family signaling R-HSA-451927 5.690735e-01 0.245 0 0
Signaling by NTRKs R-HSA-166520 5.709401e-01 0.243 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 5.767345e-01 0.239 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 5.767345e-01 0.239 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 5.767345e-01 0.239 0 0
RNA Polymerase II Transcription R-HSA-73857 5.792137e-01 0.237 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 5.810338e-01 0.236 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 5.810338e-01 0.236 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 5.810338e-01 0.236 0 0
HATs acetylate histones R-HSA-3214847 5.859926e-01 0.232 0 0
DNA Replication R-HSA-69306 5.909877e-01 0.228 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 5.916516e-01 0.228 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 5.957800e-01 0.225 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 5.967063e-01 0.224 0 0
Bacterial Infection Pathways R-HSA-9824439 6.035922e-01 0.219 0 0
Cyclin D associated events in G1 R-HSA-69231 6.060447e-01 0.217 0 0
G1 Phase R-HSA-69236 6.060447e-01 0.217 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 6.060447e-01 0.217 0 0
HIV Life Cycle R-HSA-162587 6.065866e-01 0.217 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 6.130506e-01 0.213 0 0
Fanconi Anemia Pathway R-HSA-6783310 6.130506e-01 0.213 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 6.130506e-01 0.213 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 6.130506e-01 0.213 0 0
Drug ADME R-HSA-9748784 6.166965e-01 0.210 0 0
Signaling by TGFB family members R-HSA-9006936 6.180249e-01 0.209 0 0
Nucleotide Excision Repair R-HSA-5696398 6.194885e-01 0.208 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 6.199322e-01 0.208 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 6.199322e-01 0.208 0 0
Signaling by TGFBR3 R-HSA-9839373 6.199322e-01 0.208 0 0
Diseases of DNA repair R-HSA-9675135 6.199322e-01 0.208 0 0
Neddylation R-HSA-8951664 6.264583e-01 0.203 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 6.266920e-01 0.203 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 6.266920e-01 0.203 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 6.270224e-01 0.203 0 0
Gene Silencing by RNA R-HSA-211000 6.286686e-01 0.202 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 6.331939e-01 0.198 0 0
Intraflagellar transport R-HSA-5620924 6.333318e-01 0.198 0 0
NGF-stimulated transcription R-HSA-9031628 6.333318e-01 0.198 0 0
Plasma lipoprotein remodeling R-HSA-8963899 6.333318e-01 0.198 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 6.333318e-01 0.198 0 0
Adaptive Immune System R-HSA-1280218 6.349428e-01 0.197 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 6.376761e-01 0.195 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 6.376761e-01 0.195 0 0
Gene expression (Transcription) R-HSA-74160 6.386096e-01 0.195 0 0
DNA Damage Bypass R-HSA-73893 6.398540e-01 0.194 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 6.398540e-01 0.194 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 6.398540e-01 0.194 0 0
Chemokine receptors bind chemokines R-HSA-380108 6.398540e-01 0.194 0 0
PI3K Cascade R-HSA-109704 6.462606e-01 0.190 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 6.462606e-01 0.190 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 6.551765e-01 0.184 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 6.587351e-01 0.181 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 6.587351e-01 0.181 0 0
G alpha (s) signalling events R-HSA-418555 6.615000e-01 0.179 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 6.648069e-01 0.177 0 0
Meiotic synapsis R-HSA-1221632 6.648069e-01 0.177 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 6.678555e-01 0.175 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 6.766295e-01 0.170 0 0
Paracetamol ADME R-HSA-9753281 6.766295e-01 0.170 0 0
Signaling by NOTCH3 R-HSA-9012852 6.766295e-01 0.170 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 6.823840e-01 0.166 0 0
Ion homeostasis R-HSA-5578775 6.823840e-01 0.166 0 0
Signaling by Nuclear Receptors R-HSA-9006931 6.826800e-01 0.166 0 0
Dectin-2 family R-HSA-5621480 6.880364e-01 0.162 0 0
Nuclear Envelope Breakdown R-HSA-2980766 6.880364e-01 0.162 0 0
IRS-mediated signalling R-HSA-112399 6.880364e-01 0.162 0 0
Generic Transcription Pathway R-HSA-212436 6.924665e-01 0.160 0 0
Dual incision in TC-NER R-HSA-6782135 6.935887e-01 0.159 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 6.935887e-01 0.159 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 6.935887e-01 0.159 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 6.990424e-01 0.155 0 0
Peroxisomal protein import R-HSA-9033241 6.990424e-01 0.155 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 6.990424e-01 0.155 0 0
Disorders of transmembrane transporters R-HSA-5619115 7.042717e-01 0.152 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 7.043994e-01 0.152 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 7.043994e-01 0.152 0 0
Kinesins R-HSA-983189 7.043994e-01 0.152 0 0
Regulation of PTEN gene transcription R-HSA-8943724 7.043994e-01 0.152 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 7.043994e-01 0.152 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 7.043994e-01 0.152 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 7.043994e-01 0.152 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 7.043994e-01 0.152 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 7.096613e-01 0.149 0 0
Peptide ligand-binding receptors R-HSA-375276 7.106701e-01 0.148 0 0
tRNA processing in the nucleus R-HSA-6784531 7.148300e-01 0.146 0 0
Heme signaling R-HSA-9707616 7.148300e-01 0.146 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 7.148300e-01 0.146 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 7.184946e-01 0.144 0 0
Ion channel transport R-HSA-983712 7.198186e-01 0.143 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 7.199069e-01 0.143 0 0
IGF1R signaling cascade R-HSA-2428924 7.248937e-01 0.140 0 0
Insulin receptor signalling cascade R-HSA-74751 7.248937e-01 0.140 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 7.297921e-01 0.137 0 0
Transmission across Chemical Synapses R-HSA-112315 7.354814e-01 0.133 0 0
DNA Double Strand Break Response R-HSA-5693606 7.393296e-01 0.131 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 7.393296e-01 0.131 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 7.439718e-01 0.128 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 7.492279e-01 0.125 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 7.514501e-01 0.124 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 7.530104e-01 0.123 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 7.530104e-01 0.123 0 0
Retinoid metabolism and transport R-HSA-975634 7.574098e-01 0.121 0 0
Metabolism of cofactors R-HSA-8978934 7.574098e-01 0.121 0 0
ECM proteoglycans R-HSA-3000178 7.574098e-01 0.121 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 7.617311e-01 0.118 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 7.617311e-01 0.118 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 7.659756e-01 0.116 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 7.659756e-01 0.116 0 0
Unfolded Protein Response (UPR) R-HSA-381119 7.687115e-01 0.114 0 0
Keratinization R-HSA-6805567 7.700511e-01 0.113 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 7.701448e-01 0.113 0 0
Signaling by ERBB4 R-HSA-1236394 7.701448e-01 0.113 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 7.742400e-01 0.111 0 0
Iron uptake and transport R-HSA-917937 7.742400e-01 0.111 0 0
Signaling by NOTCH1 R-HSA-1980143 7.782625e-01 0.109 0 0
Late Phase of HIV Life Cycle R-HSA-162599 7.807197e-01 0.108 0 0
Nuclear Receptor transcription pathway R-HSA-383280 7.860944e-01 0.105 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 7.860944e-01 0.105 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 7.899063e-01 0.102 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 7.973284e-01 0.098 0 0
Processing of DNA double-strand break ends R-HSA-5693607 7.973284e-01 0.098 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 7.973284e-01 0.098 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 8.009408e-01 0.096 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 8.031088e-01 0.095 0 0
Asparagine N-linked glycosylation R-HSA-446203 8.054416e-01 0.094 0 0
Arachidonate metabolism R-HSA-2142753 8.083803e-01 0.092 0 0
DNA Repair R-HSA-73894 8.109062e-01 0.091 0 0
Meiosis R-HSA-1500620 8.113976e-01 0.091 0 0
Amplification of signal from the kinetochores R-HSA-141424 8.147601e-01 0.089 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 8.147601e-01 0.089 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 8.147601e-01 0.089 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 8.180628e-01 0.087 0 0
Base Excision Repair R-HSA-73884 8.306973e-01 0.081 0 0
Neurotransmitter release cycle R-HSA-112310 8.306973e-01 0.081 0 0
Metabolism of nucleotides R-HSA-15869 8.372809e-01 0.077 0 0
Cell surface interactions at the vascular wall R-HSA-202733 8.391980e-01 0.076 0 0
Signaling by Insulin receptor R-HSA-74752 8.395958e-01 0.076 0 0
Collagen formation R-HSA-1474290 8.452677e-01 0.073 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 8.534028e-01 0.069 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 8.585699e-01 0.066 0 0
Leishmania parasite growth and survival R-HSA-9664433 8.585699e-01 0.066 0 0
Post-translational protein phosphorylation R-HSA-8957275 8.585881e-01 0.066 0 0
Regulation of insulin secretion R-HSA-422356 8.585881e-01 0.066 0 0
Epigenetic regulation of gene expression R-HSA-212165 8.632013e-01 0.064 0 0
Mitotic Spindle Checkpoint R-HSA-69618 8.635905e-01 0.064 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 8.655216e-01 0.063 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 8.684166e-01 0.061 0 0
PI Metabolism R-HSA-1483255 8.684166e-01 0.061 0 0
Cellular Senescence R-HSA-2559583 8.718328e-01 0.060 0 0
Neuronal System R-HSA-112316 8.718645e-01 0.060 0 0
Platelet homeostasis R-HSA-418346 8.797503e-01 0.056 0 0
G alpha (q) signalling events R-HSA-416476 8.840585e-01 0.054 0 0
Glycosaminoglycan metabolism R-HSA-1630316 8.934784e-01 0.049 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 8.958951e-01 0.048 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 8.977549e-01 0.047 0 0
HCMV Early Events R-HSA-9609690 8.979678e-01 0.047 0 0
Post-translational protein modification R-HSA-597592 8.997147e-01 0.046 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.013758e-01 0.045 0 0
Peptide hormone metabolism R-HSA-2980736 9.048689e-01 0.043 0 0
Homology Directed Repair R-HSA-5693538 9.065690e-01 0.043 0 0
Mitotic Prophase R-HSA-68875 9.098787e-01 0.041 0 0
MHC class II antigen presentation R-HSA-2132295 9.146256e-01 0.039 0 0
Regulation of Complement cascade R-HSA-977606 9.176509e-01 0.037 0 0
Adipogenesis R-HSA-9843745 9.287207e-01 0.032 0 0
Cardiac conduction R-HSA-5576891 9.287207e-01 0.032 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.299957e-01 0.032 0 0
Integration of energy metabolism R-HSA-163685 9.360381e-01 0.029 0 0
Chromatin modifying enzymes R-HSA-3247509 9.423534e-01 0.026 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 9.446431e-01 0.025 0 0
Complement cascade R-HSA-166658 9.466077e-01 0.024 0 0
Visual phototransduction R-HSA-2187338 9.485027e-01 0.023 0 0
GPCR downstream signalling R-HSA-388396 9.485427e-01 0.023 0 0
MITF-M-dependent gene expression R-HSA-9856651 9.512203e-01 0.022 0 0
DNA Double-Strand Break Repair R-HSA-5693532 9.537950e-01 0.021 0 0
Chromatin organization R-HSA-4839726 9.539460e-01 0.020 0 0
HCMV Infection R-HSA-9609646 9.546342e-01 0.020 0 0
PPARA activates gene expression R-HSA-1989781 9.554357e-01 0.020 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.570184e-01 0.019 0 0
Regulation of TP53 Activity R-HSA-5633007 9.592880e-01 0.018 0 0
tRNA processing R-HSA-72306 9.666345e-01 0.015 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.703597e-01 0.013 0 0
Diseases of glycosylation R-HSA-3781865 9.741050e-01 0.011 0 0
Signaling by GPCR R-HSA-372790 9.770500e-01 0.010 0 0
Phospholipid metabolism R-HSA-1483257 9.771909e-01 0.010 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.816489e-01 0.008 0 0
GPCR ligand binding R-HSA-500792 9.853391e-01 0.006 0 0
Metabolism of steroids R-HSA-8957322 9.854914e-01 0.006 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.923045e-01 0.003 0 0
G alpha (i) signalling events R-HSA-418594 9.962135e-01 0.002 0 0
Fatty acid metabolism R-HSA-8978868 9.962135e-01 0.002 0 0
Diseases of metabolism R-HSA-5668914 9.972667e-01 0.001 0 0
Transport of small molecules R-HSA-382551 9.975760e-01 0.001 0 0
Biological oxidations R-HSA-211859 9.994432e-01 0.000 0 0
Metabolism R-HSA-1430728 9.999995e-01 0.000 0 0
Sensory Perception R-HSA-9709957 9.999998e-01 0.000 0 0
Metabolism of lipids R-HSA-556833 9.999999e-01 0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways